Establishment Of Murine Pregnancy Requires The Promyelocytic Leukemia Zinc Finger Transcription Factor, Lan Hai, Vineet K Maurya, Francesco J Demayo, John P Lydon

Faculty, Staff and Students Publications

Using an established human primary cell culture model, we previously demonstrated that the promyelocytic leukemia zinc finger (PLZF) transcription factor is a direct target of the progesterone receptor (PGR) and is essential for progestin-dependent decidualization of human endometrial stromal cells (HESCs). These in vitro findings were supported by immunohistochemical analysis of human endometrial tissue biopsies, which showed that the strongest immunoreactivity for endometrial PLZF is detected during the progesterone (P4)-dominant secretory phase of the menstrual cycle. While these human studies provided critical clinical support for the important role of PLZF in P4-dependent HESC decidualization, functional validation in vivo was not …

Predation Without Direction Selectivity, Jenna Krizan, Xiayingfang Song, Michael J Fitzpatrick, Ning Shen, Florentina Soto, Daniel Kerschensteiner

2020-Current year OA Pubs

Across the animal kingdom, visual predation relies on motion-sensing neurons in the superior colliculus (SC) and its orthologs. These neurons exhibit complex stimulus preferences, including direction selectivity, which is thought to be critical for tracking the unpredictable escape routes of prey. The source of direction selectivity in the SC is contested, and its contributions to predation have not been tested experimentally. Here, we use type-specific cell removal to show that narrow-field (NF) neurons in the mouse SC guide predation. In vivo recordings demonstrate that direction-selective responses of NF cells are independent of recently reported stimulus-edge effects. Monosynaptic retrograde tracing reveals …

Faculty Spotlight: An Interview With Dr. Christian Zorman

Discussions

Dr. Chris Zorman is the associate Dean for research in the Case Western Reserve University School of Engineering and a professor in the Department of Electrical Engineering and Computer Science. His current research interests include microsystems and nanosystems. This interview has been edited for length and clarity with Dr. Zorman’s consent.

Framing An Adversary: Ethnic Nationalism In The First Khmer Newspaper, Ian Lowman

The Thetean: A Student Journal for Scholarly Historical Writing

The study of nationalism examines both global patterns and the singleness of local response. In most fledgling nation-states, the modern phenomena of print and western capitalism transformed indifferent individuals into a politicized public. Printing houses profitably publicized and glorified vernaculars while propagating European ideas of state borders, national cultures, and patriotism. By employing this medium, nationalists toyed with ideologies specific to the concerns of their community; French nationalism thrived on an abstract battle against tyranny while Algerians couched their nationality in the struggle for freedom from France. Each nation's self-conception reflected a search for an ideal of commonality and a …

Histrionicus Histrionicus Histrionicus: Common Wild Ducks And Storytelling Animal, Kira Symington

Floodwall Magazine

No abstract provided.

“Éowyn It Was, And Dernhelm Also”: Reading The ‘Wild Shieldmaiden’ Through A Queer Lens., Sara Brown

Journal of Tolkien Research

The Éowyn we first meet in 'The Two Towers' is a woman who has been traumatised by the loss of her parents at a young age, the recent loss of her cousin Théodred, the apparent weakening of her uncle Théoden, and her inability to escape the lascivious gaze of Wormtongue. Marginalised by her gender and by social expectation, her desire to find purpose in her life as a shieldmaiden is repeatedly thwarted. Seeking to reclaim control over her life and to make her own choices, she rides out with the Rohirrim not as Éowyn, but as Dernhelm.

Past scholars have …

Scale Of Patchiness Affects The Relation Between Forage Quality And Patch Choice By Cattle, Wallis Devries, M F. Laca, E A. Laca

IGC Proceedings (1977-2023)

We predicted and tested the effects of scale of heterogeneity on movements and selectivity of a large grazer in a controlled field experiment. We created random mosaics of short/high quality and tall/low quality grass patches in equal proportion at grid sizes of 2x2 m and 5x5 m. Subsequently, we monitored the foraging behavior of four steers in 16 20x40 m plots over 30-minute periods. As predicted, the animals selected the short patches both by walking in a nonrandom manner and by concentrating their grazing time. Selectivity was more pronounced in large patches than in small ones. In contrast, the number …

Spatial Analysis Of Land Use By Cattle Herds In A Village Of The Sudanese Zone In Senegal. Application For Grazing System Improvement, A Ickowicz, J C. Usengumuremyi, D Bastien, N De Choudens

IGC Proceedings (1977-2023)

Spatial analysis of land use by cattle herds in the sub-humid area of Senegal is conducted through the utilisation of a Geographic Information System. This tool allows us to establish relationships between spatial practices, ruminant nutrition and performances. It gives leads to proposals for the improvement of the extensive ruminant feeding system.

Using Cuticular Wax Alkanes And Computer Simulation To Estimate Diet Selection, Herbage Intake And Nutrient Cycling In Grazing Sheep, H Dove, R J. Simpson

IGC Proceedings (1977-2023)

In grazing ewes, plant cuticular wax alkanes were used as markers to estimate diet selection, herbage intake, N intake and N excretion in faeces. Pasture and animal data were then used as inputs to the decision-support system GrazFeed, which simulates grazing and digestion to predict herbage intake, N intake and N excretion. Estimated and predicted intakes agreed closely, especially for N intake, and it is concluded that, subject to further investigation of the possibility that GrazFeed slightly under-estimated faecal N excretion, the close agreement between estimated and predicted OM and N intakes suggests that this combined use of alkane methods …

Effect Of Species Horizontal Distribution On Defoliation Of Ryegrass-Clover Swards Grazed By Sheep, P C. De Faccio Carvalho, F Louault, M Lafarge

IGC Proceedings (1977-2023)

Defoliation events on labelled white clover (Trifolium repens) growing points or ryegrass (Lolium perenne) tillers were measured during grazing tests by sheep with swards consisting of mixed ryegrass-clover (MIX) or alternate strips of clover and ryegrass (STRIP). Sward surface height was maintained at 6.4 cm by lawnmower cuts in order to obtain a similar surface height for both species. On average, during 13 grazing tests in STRIP and 11 in MIX swards, clover was the more defoliated species : 23.3% of the growing points in STRIP and 26.5% in MIX swards were defoliated compared to 16.2% …

Foraging Behavior Of Zebu Cattle Grazing Deciduous Forest, L Ortega, J Castillo, F Rivas

IGC Proceedings (1977-2023)

The objective of this study was to determine whether the foraging behavior of Zebu cattle in deciduous forest was affected by time of the year. Data were recorded during the wet, nortes and dry seasons. Ten Zebu cows were used to record biting rate. Intake and bite size was estimated using three esophageally fistulated animals. Cattle browsed shrubs and trees in the wet season and ingested litter leaves in the dry season which resulted in differences of ingestive behavior. In general, bite size and intake were higher in the wet season and decreased during the nortes and dry seasons.

Behaviour Of Cattle On Two Different Types Of Upland Pastures, D Macesic, M Knezevic

IGC Proceedings (1977-2023)

The purpose of this research was to study the influence of the quality of pastures on the behaviour of cows in a 'cow-calf' system. The behaviour was measured by the four principal activities of the herd: grazing, lying, 'roaming' and insect repelling, and it is presented with relative indicators. The trial was conducted on pasture areas of the Faculty of Agriculture, University of Zagreb, at the altitude of 650- 850 m. The influence of the pasture quality on the behaviour of cattle on pasture was studied on two different types of pastures: a natural unreclaimed pasture belonging to the Arrhenatheretum …

Foraging Behaviour Of Heifers, Sheep And Goats In Grass-Legume Cafeteria, J P. Singh, Vinod Shankar, V S. Upadhyay

IGC Proceedings (1977-2023)

The paper reports findings of a grazing trial with heifers, sheep and goats in a grass–legume cafeteria involving 45x10 m alternate strips of 18 grasses and 18 legumes. In the first year heifers were grazed. Sheep were introduced in the second year and goats in the third year. The stocking rate was 1.5 ACU/ha. Foraging behaviour of three kinds of animals differed in many respects with grazing and rest durations, choice of species in the forenoon and afternoon and in different seasons. Heifers, by and large, preferred grasses over legumes and browse. Sheep, on the contrary, preferred legumes over grasses …

Effects Of Defoliation Frequency On Foraging Selective Behaviour In Pasture With Paspalum Dilatatum, G L. Acosta, A T. Ayala Torales, V A. Deregibus

IGC Proceedings (1977-2023)

The objective was to assess defoliation effects exerted by sheep grazing on a pasture composed by falaris and dallisgrass, at two phenological stages during spring and summer. A sown pasture of Phalaris aquatica and Paspalum dilatatum were grazed at two phenological stages: stage I (SI), with no more than 5% of reproductive tillers, and stage II (SII), with at least 70% of reproductive tillers. Tillers of both grass species were marked with plastic colour rings along two transects in each plot. Phenological stage of tillers, and the number, age and length of each leaf per tiller were registered. Tiller defoliation …

Characterization Of Grazing Patterns In Cool-Season Annual And Warm-Season Perennial Grass Pastures, G E. Aiken, M S. West, D I. Bransby

IGC Proceedings (1977-2023)

Pastures are often either under- or over-grazed, which can affect both pasture sustainability and livestock performance. Disk meter heights were measured for rye (Secale cereale L.) -ryegrass (Lolium L. multiflorum Lam.) pasture to characterize stocking rate (2.5, 3.7, and 4.9 steers/ha) effects on grazing patterns. In another study, grazing indices were calculated for bermudagrass [Cynodon dactylon (L.) Pers.] to describe pasture utilization over time for three stocking rates (3.0, 5.9, 8.9 steers/ha). Distributions of DMH for rye-ryegrass showed distinct grazing patterns for each stocking rate, with the distributions changing from bimodal to multi-modal from heavy to light …

Border Effects On Cattle Grazing Preference, G E. Shewmaker, H F. Mayland, S B. Hansen

IGC Proceedings (1977-2023)

The objective was to examine the effect of row position on cattle grazing preference. Grazing preference of eight tall fescues [Festuca arundinacea (Schreb.)] was evaluated by ocular preference scores at 30 hr (PS30) and 48 hr (PS48). Six rows of a cultivar—numbered consecutively within each plot from left to right—formed one plot. Rows 1&6 were on the outside edges of the plot and rows 3&4 were in the middle. Within a replication, rows 1 and 6 were adjacent to rows 6 and 1 of adjacent plots, respectively. During the first year, row position was not a significant effect. However, …

Intake And Diet Selection By Sheep Grazing Grass/Clover Patches, I J. Gordon, A W. Illius

IGC Proceedings (1977-2023)

The effects of the spatial dispersion of ryegrass (Lolium perenne L) and clover (Trifolium repens L), at the feeding station scale, on diet composition and feeding behaviour were studied for sheep. There were no significant changes in diet composition with changes in the spatial dispersion of sward components. Bite size, bite rate and intake rate did increase as the species became more aggregated.

Relationships Between The Nutrient Content Of Irrigated Pasture On Offer And That Selected By Grazing Dairy Cows, W J. Wales, C R. Stockdale, P T. Doyle

IGC Proceedings (1977-2023)

An experiment was conducted to determine the dry matter, energy, crude protein and fibre intake by dairy cows in late lactation when grazing perennial pasture offered at allocations of 15, 20, 30 and 40 kg DM/cow.day. The cows consistently selected a diet 10% higher in digestibility than that on offer. In contrast, cows selected diets with crude protein levels increasing from 22% to 40%, above that in pasture on offer, as pasture allocation increased. A similar pattern was observed for the intake of white clover (Trifolium repens L). The increase in the concentration of crude protein in the diet …

Species Preference Influences On Cattle Grazing Behaviour, G P. Cosgrove, C B. Anderson, R H. Fletcher

IGC Proceedings (1977-2023)

Lotus corniculatus offers specific nutritional benefits to animals, but exploiting these advantages in grazing systems depends on the proportion of lotus in the feed offered and the animals' preference, hence desire to select for it. To determine preference for lotus, heifers were offered free-choice in contrasting, spatially separated but adjacent monocultures of ryegrass-lotus or red clover-lotus. Following a one-week period to adjust to the species offered and their arrangement, 10 young heifers were observed at 10-minute intervals during daylight hours, and the species they were on and whether or not they were grazing was recorded. This procedure was conducted in …

Partial Preference Of Grazing Cattle For Contrasting Legume Swards, C.H. E.C. Poli, J Hodgson, G P. Cosgrove, G C. Arnold

IGC Proceedings (1977-2023)

Yearling heifers in groups of 3 grazed 405 m2 plots made up of alternating 2.4m wide strips of white clover/birdsfoot trefoil (WC+BT) or red clover (RC) in the proportions of 80:20, 67:33, 33:67 and 20:80 for periods of 3 days over four replicates in time, balanced for effects of previous treatment. Observation of the distribution of grazing activity and biting rate were made over 3 hour periods each evening. Biting rates were consistently higher on (WC+BT) than RC (52.3 vs 46.3 ± 0.59 bites.min-1 P(0.0001). Animals initially showed partial preference for the minor sward component in each treatment but regression …

The Use Of Vibration Analysis And Telemetry To Measure Bite Frequency And Intensity In Free-Ranging Horned Ruminants, P R. Lawrence, K Becker

IGC Proceedings (1977-2023)

An apparatus is described which detects and measures the vibrations in a ruminant’s horn especially those produced by the animal’s teeth. Vibrations are transmitted by radio to a portable computer where those produced as a result of eating and ruminating can be characterised by their intensity, length and frequency.

Influence Of Vegetation Patch Characteristics On Discriminatory Grazing By Dairy Cows, W M. Griffiths, J Hodgson, G C. Arnold, C W. Homes

IGC Proceedings (1977-2023)

Two studies involving the sequential grazing of sets of patches on a perennial ryegrass (Lolium perenne) sward were carried out to investigate the effects of patch characteristics on the selective behaviour of grazing cattle. Experiment 1 involved a range of combinations of sward height (8.9 - 19.6 cm) and bulk density (1.33 - 1.67 mg DM/cm3). Distribution of grazing activity (number of bites or residence time) was strongly and positively related to patch height, but additional effects of variation in bulk density were limited. In Experiment 2 patches were manipulated to offer contrasts in both height (13.4 and …

Shade For Cattle On Pasture: A Guide For Ontario Producers, E J. Finegan, T M. Widowski

IGC Proceedings (1977-2023)

In tropical climates, adequate shade may be essential to ensure the survival and productivity of grazing animals, but in the temperate Ontario climate, the necessity or benefits of providing shade for grazing cattle are less clear, and have proved controversial. Meteorological data indicate that beef cattle in Ontario may be at risk of suffering from heat stress on more than 25% of days during July and August, and may decrease feed intake and benefit from the provision of shade for more than 50% of days during the two hottest summer months. A booklet, entitled ‘Beat the Heat. A Guide …

A Multi-Omics Investigation Into The Mechanism Of Action Of An Anti-Tubercular Fatty Acid Analog, Isin T. Sakallioglu, Amith S. Maroli, Aline De Lima Leite, Darrell D. Marshall, Boone W. Evans, Denise K. Zinniel, Patrick H. Dussault, Raul G. Barletta, Robert Powers

Patrick Dussault Publications

The mechanism of action (MoA) of a clickable fatty acid analogue 8-(2-Cyclobuten-1-yl)octanoic acid (DA-CB) has been investigated for the first time. Proteomics, metabolomics, and lipidomics were combined with a network analysis to investigate the MoA of DA-CB against Mycobacterium smegmatis (Msm). The metabolomics results showed that DA-CB has a general MoA related to that of ethionamide, a mycolic acid inhibitor that targets enoyl-ACP reductase (InhA), but DA-CB likely inhibits a step downstream from InhA. Our combined multi-omics approach showed that DA-CB appears to disrupt the pathway leading to the biosynthesis of mycolic acids, an essential mycobacterial fatty acid …

Combining Multi-View Uav Photogrammetry, Thermal Imaging, And Computer Vision Can Derive Cost-Effective Ecological Indicators For Habitat Assessment, Qiao Hu, Ligang Zhang, Jeff Drahota, Wayne Woldt, Dana Varner, Andy Bishop, Ted Lagrange, Christopher M. U. Neale, Zhenghong Tang

School of Natural Resources: Faculty Publications

Recent developments in Unmanned Aircraft Vehicles (UAVs), thermal imaging, and Automachine learning (AutoML) have shown high potential for precise wildlife surveys but have rarely been studied for habitat assessment. Here, we propose a framework that leverages these advanced techniques to achieve cost-effective habitat quality assessment from the perspective of actual wildlife community usage. The framework exploits vision intelligence hidden in the UAV thermal images and AutoML methods to achieve cost-effective wildlife distribution mapping, and then derives wildlife use indicators to imply habitat quality variance. We conducted UAV-based thermal wildlife surveys at three wetlands in the Rainwater Basin, Nebraska. Experiments were …

The Impact Of Social-Emotional Competence On Academic Achievement And Career Success Within Urban School Systems, Lashanda R. Boone, Keesha Byrd, Susan Grimes, Jamesha Purdiman, Cierra Wourman

Dissertations

Abstract

This dissertation investigates the critical role of social-emotional learning (SEL) in urban education through the lens of educators working in a diverse middle school setting in St. Louis, Missouri. With a focus on understanding educators' perceptions and experiences, this study aims to explore the effectiveness of SEL programs in addressing the various needs of students, particularly those from marginalized communities. The researchers use a qualitative approach, utilizing surveys with open-ended questions to gather insights from middle school teachers, counselors, support staff, and administrators. The study dove into various aspects of SEL implementation through rigorous data collection and analysis, including …

Remodeling Anaplastic Thyroid Cancer’S Aggressive Profile And Metabolic Signature By Natural Alkaloid Berberine, Tara Jarboe

NYMC Student Theses and Dissertations

Anaplastic thyroid cancer is a rare, fatal cancer with a five-year survival of 4%. Universally diagnosed at stage IV, anaplastic thyroid cancer is characterized by its lack of differentiation, rapid proliferative rate, highly inflammatory tumor microenvironment, and metabolic dysregulation. Refractory to all established therapies, anaplastic thyroid cancer requires a novel therapeutic approach that targets all of these drivers of anaplastic thyroid cancer carcinogenesis. We propose natural alkaloid berberine as a therapeutic with multitarget efficacy to alter mitochondrial metabolism and reprogram anaplastic thyroid cancer’s aggressive phenotype. Our in vitro model uses monocyte cell line U937, anaplastic thyroid cancer cell lines T238 …

Remodeling Anaplastic Thyroid Cancer's Aggressive Profile And Metabolic Signature By Natural Alkaloid Berberine, Tara Elizabeth Jarboe

NYMC Student Theses and Dissertations

Anaplastic thyroid cancer is a rare, fatal cancer with a five-year survival of 4%. Universally diagnosed at stage IV, anaplastic thyroid cancer is characterized by its lack of differentiation, rapid proliferative rate, highly inflammatory tumor microenvironment, and metabolic dysregulation. Refractory to all established therapies, anaplastic thyroid cancer requires a novel therapeutic approach that targets all of these drivers of anaplastic thyroid cancer carcinogenesis. We propose natural alkaloid berberine as a therapeutic with multitarget efficacy to alter mitochondrial metabolism and reprogram anaplastic thyroid cancer’s aggressive phenotype. Our in vitro model uses monocyte cell line U937, anaplastic thyroid cancer cell lines T238 …

The Rider (2024-03-18), Natalie Lapsley

The Rider Archives

Vol.9 No.23

Point Of View On Outcome Prediction Models In Post-Stroke Motor Recovery, Onno Van Der Groen, Manonita Ghosh, Richard Norman, Amy Kuceyeski, Ceren Tozlu, Teresa J. Kimberley, David J. Lin, Laurel J. Buxbaum, Gert Kwakkel, Steven C. Cramer, Dylan J. Edwards

Moss-Magee Rehabilitation Papers

Stroke is a leading cause of disability worldwide which can cause significant and persistent upper limb (UL) impairment. It is difficult to predict UL motor recovery after stroke and to forecast the expected outcomes of rehabilitation interventions during the acute and subacute phases when using clinical data alone. Accurate prediction of response to treatment could allow for more timely and targeted interventions, thereby improving recovery, resource allocation, and reducing the economic impact of post-stroke disability. Initial motor impairment is currently the strongest predictor of post-stroke motor recovery. Despite significant progress, current prediction models could be refined with additional predictors, and …