Digital Commons Network^™

Cross-Cousin Marriage Among Tsimane Forager–Horticulturalists During Demographic Transition And Market Integration, Arianna Dalzero, Bret A. Beheim, Hillard Kaplan, Jonathan Stieglitz, Paul L. Hooper, Cody T. Ross, Michael D. Gurven, Dieter Lukas

ESI Publications

Although still prevalent in many human societies, the practice of cousin marriage has precipitously declined in populations undergoing rapid demographic and socioeconomic change. However, it is still unclear whether changes in the structure of the marriage pool or changes in the fitness-relevant consequences of cousin marriage more strongly influence the frequency of cousin marriage. Here, we use genealogical data collected by the Tsimane Health and Life History Project to show that there is a small but measurable decline in the frequency of first cross-cousin marriage since the mid-twentieth century. Such changes are linked to concomitant changes in the pool of …

Hearing Loss Vs Length Of Employment In The Steel Industry, Sarah Jane Hattle

Student Theses and Dissertations

The purpose of this research was to investigate if there was a relationship between hearing loss and length of employment in the steel industry. Participants included 11 males that worked in the steel industry. Participants completed questionnaires regarding demographics, employment, and noise exposure, as well as took part in an audiological exam. The results of the audiological evaluations showed that 45% of participants had hearing loss in the right ear, 36% of participants had hearing loss in the left ear, and 36% of participants had loss in both ears. While there was no significant relationship between hearing loss and the …

Examining The Influence Of Teacher And Student Variables On Teachers’ Levels Of Self-Efficacy, Rachel Pugh

Student Theses and Dissertations

The purpose of this descriptive correlational quantitative study was to examine contributing factors of students and teachers affecting teacher self-efficacy and students' reading achievement in rural Oklahoma elementary schools in grades first through fifth. The contributing factors of students being analyzed included (a) poverty and (b) race or ethnic backgrounds. The teachers’ contributing factors include their self-efficacy levels on students' reading achievement, instructional strategies, classroom management, and student engagement levels. The proposed theory was that student and teacher variables beyond their control influenced teachers' self-efficacy levels in poverty-stricken classrooms. The study employed a quantitative approach, which used an online questionnaire …

The Myths Of Plato: Socratic Kenosis And The Call Of Beauty, Daniel Edward Shirley

Master of Arts in Classical Studies

The myths of Plato have been inordinately subordinated to the “intellect” of Plato since the eighteen-thirties. The ancient Christian tradition of interpreting stories and scriptures with symbolic understanding serves as a potentially primary hermeneutical pattern that could correct the modern tendency of subconscious materialism. To restore the Platonic myths, there are two foundational arguments to be made about the myths. The first is that these myths are kenotic in function. Observing the Socratic call to self-emptying, especially in the cosmological image of the World Axis, challenges modern assumptions concerning the second goodness of Platonic myth. The second argument is the …

A Review On Role Of Bacillus Species In Bio-Calcification: A Way Forward In Carbonate Precipitation, Ardil Bin Mansoor, Sheema Yousaf, Amna Gulzar, Ramsha Iqbal, Aisha Waheed Qurashi

Journal of Bioresource Management

Bio-calcification, also known as microbiologically induced calcite precipitation, is a phenomenon involving the activity of the enzyme urease. A large number of soil microorganism exhibit urease-producing ability. The main purpose of this review article is to signify the calcium carbonate bio-precipitation by Bacillus species including Lysinibacillus sphaericus and Bacillus subtilis. They both precipitated calcite and the shape and size depending on the external and internal conditions like the type of culture medium and the bacterial strains that were used. The research group increased attentions toward MICP (microbial-induced carbonated precipitation) because of its eco-friendly application. Different bacterial strains had been …

Impact Of Infestation Of Flour By Stored Food Pest Insects Ephestia Kuehniella On Quality Flour: Physico-Chemical Analyses, Hadjira Bendjedid, Samira Yezli-Touiker, Asma Taffar, Amina Yezli, Nabila Souileh

Journal of Bioresource Management

The primary reason for significant post-harvest losses globally stems from the infestation of insect pests. These beetles, as they progress through their life cycle, lead to the deterioration of stored food, capable of decimating an entire inventory within a remarkably brief timeframe. Quality control is a system that monitors product quality, assuring and detecting any spoilage of a product, the impact of infestation of flour by pairs of stored food pest insects E. kuehniella on quality flour was evaluated by physicochemical analyses over time. Provoked exposure of 200 g of flour to 5, 10, and 20 couples of Ephestia keuhniella …

Raf Inhibitor Re-Challenge Therapy In Braf-Aberrant Pan-Cancers: The Re-Raffle Study, Blessie Elizabeth Nelson, Jason Roszik, Jibran Ahmed, Carmelia Maria Noia Barretto, Mirella Nardo, Erick Campbell, Amber M Johnson, Sarina A Piha-Paul, Isabella C Glitza Oliva, Shiao-Pei Weathers, Maria Cabanillas, Milind Javle, Funda Meric-Bernstam, Vivek Subbiah

Faculty, Staff and Student Publications

Previous studies have shown the clinical benefit of rechallenging the RAF pathway in melanoma patients previously treated with BRAF inhibitors. 44 patients with multiple tumors harboring RAF alterations were rechallenged with a second RAF inhibitor, either as monotherapy or in combination with other therapies, after prior therapy with a first RAF inhibitor. This retrospective observational study results showed that rechallenging with RAFi(s) led to an overall response rate of 18.1% [PR in thyroid (1 anaplastic; 3 papillary), 1 ovarian, 2 melanoma, 1 cholangiocarcinoma, and 1 anaplastic astrocytoma]. The clinical benefit rate was 54.5%; more than 30% of patients had durable …

Biomarkers For Managing Neurodegenerative Diseases, Lara Cheslow, Adam E. Snook, Scott A. Waldman

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Neurological disorders are the leading cause of cognitive and physical disability worldwide, affecting 15% of the global population. Due to the demographics of aging, the prevalence of neurological disorders, including neurodegenerative diseases, will double over the next two decades. Unfortunately, while available therapies provide symptomatic relief for cognitive and motor impairment, there is an urgent unmet need to develop disease-modifying therapies that slow the rate of pathological progression. In that context, biomarkers could identify at-risk and prodromal patients, monitor disease progression, track responses to therapy, and parse the causality of molecular events to identify novel targets for further clinical investigation. …

Pre And Post Breeding Morphometric Profile Of European Rabbit (Oryctolagus Cuniculus), Rao Zahid Sattar, Rana Manzoor Ahmad, Abdul Majid Khan, Muhammad Altaf, Muhammad Rizwan, Sajjad Yaseen

Journal of Bioresource Management

After 1950s, a continuous decline in the population of Oryctolagus cuniculus has urged the IUCN to declare it an endangered species. There is a serious need to take conservational steps for Oryctolagus cuniculus breeds by research work on their different morphological and physiological aspects. The current study evaluates the growth of European rabbit through morphometric profile at pre breeding, post 1^st breeding and post 2^nd breeding stages in order to find out the growth trends of the European rabbits at different breeding stages. The studied sample comprised of 42 pairs for each breed (New Zealand White and American …

Usage Of Almond And Thyme Oils For The Enhancement Of Shelf Life Of Different Fish Species, Aneeza Kanwal, Roheela Yasmeen, Saima Nazir, Shumaila Usman, Bushra Nisar Khan

Journal of Bioresource Management

Fish is an important source of protein for millions of people around the globe and it's often a healthier option compared to some other meats. However, the fish industry is facing a storage challenge in the form of rapid spoilage and deterioration of freshness due to bacterial growth and enzymatic activity. The usage of oils in fish can enhance shelf life by creating a protective barrier. This research was designed to see the effects of thyme and almond oil on nutritional profile and shelf life of fish. The three fish species rohu (Labeo rohita), Mali (Wallago attu) …

Hesitation Towards The Covid-19 Vaccine In The United States: A Digital Ethnographic Study [Vacilación Ante La Vacuna Contra El Covid-19 En Estados Unidos De América: Un Estudio Etnográfico Digital], Rosalynn A. Vega

Anthropology Faculty Publications

Following the authorization of the use of COVID-19 vaccines in babies age 6 months through children 4 years old in the United States, some individuals (parents, pediatricians, and communicators) framed COVID-19 vac-cination as an issue of access, while many others expressed hesitancy, and some resisted recommendations from the US Centers for Disease Control and Prevention. In this context, this study aimed to explore: 1) divergent reactions to the authorization of COVID-19 vaccine use in children aged 6 months to 4 years; and 2) opposing logics underlying attitudes towards pro-vaccination, anti-vaccination, and vaccine hesitancy regarding COVID-19 vaccines. To achieve this, a …

Rehabilitation Counselor Interventions On Parental-Disability Acceptance, James Samuel Rothrock

Walden Dissertations and Doctoral Studies

No abstract provided.

Mississippi Day 2024 To Include Robots, Reptiles And Refreshments, Edwin Smith

University of Mississippi News

OXFORD, Miss. – The University of Mississippi will put a spotlight on the Magnolia State during the 2024 Mississippi Day on April 13.

Book Review Of Hadley Vlahos. 2023. The In-Between; Unforgettable Encounters During Life’S Final Moments. Ballantine Books: New York, Roger Clark, Emily Stier Adler

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.

Cancer Patients’ Spiritual Well-Being, Religious Coping, And Comfort In Communicating With Physicians, Cheryl Boettger

Walden Dissertations and Doctoral Studies

No abstract provided.

Discovery Of Sqstm1/P62-Dependent P-Bodies That Regulate The Nlrp3 Inflammasome, Elizabeth R. Barrow, Evelina Valionyte, Chris R. Baxter, Yi Yang, Sharon Herath, William A. O'Connell, Justyna Lopatecka, Alexander Strachan, Waldemar Woznica, Holly N. Stephenson, Gyorgy Fejer, Vikram Sharma, Boxun Lu, Shouqing Luo

School of Biomedical Sciences

Autophagy and ribonucleoprotein granules, such as P-bodies (PBs) and stress granules, represent vital stress responses to maintain cellular homeostasis. SQSTM1/p62 phase-separated droplets are known to play critical roles in selective autophagy; however, it is unknown whether p62 can exist as another form in addition to its autophagic droplets. Here, we found that, under stress conditions, including proteotoxicity, endotoxicity, and oxidation, autophagic p62 droplets are transformed to a type of enlarged PBs, termed p62-dependent P-bodies (pd-PBs). p62 phase separation is essential for the nucleation of pd-PBs. Mechanistically, pd-PBs are triggered by enhanced p62 droplet formation upon stress stimulation through the interactions …

Identifying Potential Dietary Treatments For Inherited Metabolic Disorders Using Drosophila Nutrigenomics, Felipe Martelli, Jiayi Lin, Sarah Mele, Wendy Imlach, Oguz Kanca, Christopher K Barlow, Jefferson Paril, Ralf B Schittenhelm, John Christodoulou, Hugo J Bellen, Matthew D W Piper, Travis K Johnson

Faculty, Staff and Students Publications

Inherited metabolic disorders are a group of genetic conditions that can cause severe neurological impairment and child mortality. Uniquely, these disorders respond to dietary treatment; however, this option remains largely unexplored because of low disorder prevalence and the lack of a suitable paradigm for testing diets. Here, we screened 35 Drosophila amino acid disorder models for disease-diet interactions and found 26 with diet-altered development and/or survival. Using a targeted multi-nutrient array, we examine the interaction in a model of isolated sulfite oxidase deficiency, an infant-lethal disorder. We show that dietary cysteine depletion normalizes their metabolic profile and rescues development, neurophysiology, …

A Therapeutically Targetable Positive Feedback Loop Between Nc-Hlx-2-7, Hlx, And Myc That Promotes Group 3 Medulloblastoma, Keisuke Katsushima, Kandarp Joshi, Menglang Yuan, Brigette Romero, Mona Batish, Stacie Stapleton, George Jallo, Elayaraja Kolanthai, Sudipta Seal, Olivier Saulnier, Michael D Taylor, Robert J Wechsler-Reya, Charles G Eberhart, Ranjan J Perera

Faculty, Staff and Students Publications

Recent studies suggest that long non-coding RNAs (lncRNAs) contribute to medulloblastoma (MB) formation and progression. We have identified an lncRNA, lnc-HLX-2-7, as a potential therapeutic target in group 3 (G3) MBs. lnc-HLX-2-7 RNA specifically accumulates in the promoter region of HLX, a sense-overlapping gene of lnc-HLX-2-7, which activates HLX expression by recruiting multiple factors, including enhancer elements. RNA sequencing and chromatin immunoprecipitation reveal that HLX binds to and activates the promoters of several oncogenes, including TBX2, LIN9, HOXM1, and MYC. Intravenous treatment with cerium-oxide-nanoparticle-coated antisense oligonucleotides targeting lnc-HLX-2-7 (CNP-lnc-HLX-2-7) inhibits tumor growth by 40%-50% in an intracranial MB xenograft mouse …

A Novel Machine Learning Algorithm Selects Proteome Signature To Specifically Identify Cancer Exosomes, Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri

Faculty, Staff and Student Publications

Non-invasive early cancer diagnosis remains challenging due to the low sensitivity and specificity of current diagnostic approaches. Exosomes are membrane-bound nanovesicles secreted by all cells that contain DNA, RNA, and proteins that are representative of the parent cells. This property, along with the abundance of exosomes in biological fluids makes them compelling candidates as biomarkers. However, a rapid and flexible exosome-based diagnostic method to distinguish human cancers across cancer types in diverse biological fluids is yet to be defined. Here, we describe a novel machine learning-based computational method to distinguish cancers using a panel of proteins associated with exosomes. Employing …

Next Generation Microfluidics: Fulfilling The Promise Of Lab-On-A-Chip Technologies, Umut A Gurkan, Jorge Di Paola, Et Al.

2020-Current year OA Pubs

Microfluidic lab-on-a-chip technologies enable the analysis and manipulation of small fluid volumes and particles at small scales and the control of fluid flow and transport processes at the microscale, leading to the development of new methods to address a broad range of scientific and medical challenges. Microfluidic and lab-on-a-chip technologies have made a noteworthy impact in basic, preclinical, and clinical research, especially in hematology and vascular biology due to the inherent ability of microfluidics to mimic physiologic flow conditions in blood vessels and capillaries. With the potential to significantly impact translational research and clinical diagnostics, technical issues and incentive mismatches …

Intergenerational Protective Anti-Gut Commensal Immunoglobulin G Originates In Early Life, Brigida Rusconi, Adina K Bard, Ryan Mcdonough, Angel M Kindsvogel, Jacqueline D Wang, Sreeram Udayan, Keely G Mcdonald, Rodney D Newberry, Phillip I Tarr

2020-Current year OA Pubs

Maternal immunoglobulins of the class G (IgGs) protect offspring from enteric infection, but when, where, and how these antibodies are physiologically generated and confer protection remains enigmatic. We found that circulating IgGs in adult mice preferentially bind early-life gut commensal bacteria over their own adult gut commensal bacteria. IgG-secreting plasma cells specific for early-life gut bacteria appear in the intestine soon after weaning, where they remain into adulthood. Manipulating exposure to gut bacteria or plasma cell development before, but not after, weaning reduced IgG-secreting plasma cells targeting early-life gut bacteria throughout life. Further, the development of this anti-gut commensal IgG …

Biological Significances Of Environmental Pollution In The New Calabar River, Southern Nigeria: A Case Study In Zooplankton Composition, Ibienebo Davies Imachrist, Francis David Sikoki, Philomina Kika, Davies Ibienebo Chris

Journal of Bioresource Management

The study was conducted for three months (May to July 2020), focusing on the physicochemical parameters and zooplankton composition in the Ogbogoro region of the New Calabar River in Nigeria. This investigation was carried out at three distinct monitoring stations. The physicochemical parameters were determined using standard ecological analytic procedures. PAST and SPSS were used for the statistical analysis. The temperature ranged between 26.5 to 33 ºC, salinity (1.23 to 1.86 %), pH (7.4 to 9.62), Total Dissolved Solids (2419 to 5,817 mg/L), conductivity (223.83 to 7,328 μS/cm), turbidity (3.415 to 15.05 NTU) and Dissolved Oxygen (3.8 to 6.8 mg/L). …

Novel Drug Approvals 2023, Emily Wagner, Christina Swiger, Mary Hoang, Maley Zents

Transformative Medicine

This article provides an overview of the novel drugs approved for 2023. The Food and Drug Administration’s (FDA) Center for Drug Evaluation and Research (CDER) provides standards to drug developers. The CDER sets standards for required data needed in the drug development and application process. Every year a variety of new drugs and biological products are approved. Some are new molecular compounds while others are structurally similar to those already on the market. Therefore, products may not have been used in medical practice previously while others have already been used in practice. This article highlights medications that are new in …

New Onset Dyspnea In A Patient With Pacemaker, What Does The Ecg Tracing Show?, Jakob Nypaver, Robert Libera Do, Arun Kundra, Ravi Choxi

Transformative Medicine

Dual chamber pacemakers are programmed to allow for AV synchrony. Whenever a patient with a dual chamber pacemaker with underlying sinus rhythm presents with AV dissociation, the lack of AV synchrony should be questioned. The authors present a case of new onset dyspnea diagnosed as pacemaker syndrome. The diagnosis was initially delayed due to underlying ventricular paced rhythm as misidentified as normal pacemaker behavior.

A 69-year-old female with a past medical history of 2:1 atrioventricular block status post dual-chamber pacemaker implant presented with complaints of new onset shortness of breath and dyspnea. The ECG showed a ventricular rate of 66 …

Autoimmune Hemolytic Anemia: A Rare Presentation Of Mantle Cell Lymphoma, Ian Garrahy, Shoja Rahimian

Transformative Medicine

Autoimmune hemolytic anemia (AIHA) is a well-recognized phenomenon of non-Hodgkin lymphoma, albeit with only few cases described with mantle cell lymphoma (MCL). The characteristics of such cases can improve understanding and management of AIHA in this type of lymphoma. To that end, we describe herein two cases of patients with MCL who presented with AIHA, with comparison to nine previously described cases in literature.

Empathy, Education, & Empowerment: Reflections On The World Of Dementia, Samantha Heyer, Jordan Neely, Sarah Stegge, Elaine M. Eshbaugh

Research in the Capitol

At the Dementia Simulation House, we offer the opportunity for participants to experience what life may be like for someone living with dementia in a home setting. About 80% of individuals living with dementia live at home in the community, and we aim to show participants what it might be like for these individuals to complete chores and activities of daily living. During the simulation, we put gear on an individual to simulate dementia. Then participants go through a debriefing which involves writing a reaction word. We sorted the reaction words and calculated percentages on the popularity/common phrases or words …

Political Orientation And Moral Values: Examining Their Effects On Susceptibility To Misinformation, Makayla L. Hall, Jordan A. Neely, Helen C. Harton

Research in the Capitol

According to past research, political misinformation is prevalent within social media, where information often goes unchecked. Both liberals and conservatives tend to believe misinformation that supports their beliefs. Values emphasized also tend to differ by political orientation, with liberals being more concerned with issues of harm, fairness, and universalism, and conservatives, with loyalty, authority, purity, and self-reliance. This study examines whether misinformation susceptibility is influenced by which of these values the information appeals to. 136 participants read social media posts that either supported or did not support their party’s platforms and that appealed to one of the seven values. They …

Characterization Of Mtdna Minicircles In A Chewing Louse, Geomydoecus Centralis, John Lehmkuhl, Grace Mraz, James W. Demastes, Theresa A. Spradling

Research in the Capitol

The DNA of living organisms is packaged into chromosomes differently in different species, but typically following a standard set of "rules." Understanding how DNA can be packaged for different species provides a better understanding of life and the genetic rules that must be followed, and the "rules" that can be broken. Mitochondria are crucial subcomponents of cells, providing the energy for life. Mitochondria always have their own mtDNA. In our study, we have learned that chewing lice mtDNA differs from that of other animals by spreading the genes across 12 separate small, circular chromosomes instead of one large, circular chromosome. …

An Argument For Expanding Research On Quantitative Pedagogical Content Knowledge, Randall E. Groth

Numeracy

Pedagogical content knowledge (PCK) traditionally has been used in research concerning prospective and practicing classroom teachers. This essay argues that PCK is also relevant to other professions including those advancing quantitative reasoning (QR). To illustrate, the case of PCK for teaching QR is considered. Those in fields such as public health, journalism, meteorology, and government increasingly find themselves responsible for helping the public understand an ever-growing amount of quantitative information that has a bearing on societal well-being. Several examples illustrate how such professionals’ responsibilities require knowing prevalent QR patterns in society, strategies for fostering sound reasoning, and the general nature …

Genomes Of Multicellular Algal Sisters To Land Plants Illuminate Signaling Network Evolution, Xuehuan Feng, Jinfang Zheng, Iker Irisarri, Huihui Yu, Bo Zheng, Zahin Ali, Sophie De Vries, Jean Keller, Janine M. R. Fürst-Jansen, Armin Dadras, Jaccoline M. S. Zegers, Tim P. Rieseberg, Amra Dhabalia Ashok, Tatyana Darienko, Maaike J. Bierenbroodspot, Lydia Gramzow, Romy Petroll, Fabian B. Haas, Noe Fernandez-Pozo, Orestis Nousias, Tang Li, Elisabeth Fitzek, W. Scott Grayburn, Nina Rittmeier, Charlotte Permann, Florian Rümpler, John M. Archibald, Günter Theißen, Jeffrey P. Mower, Maike Lorenz16, Henrik Buschmann, Klaus Von Schwartzenberg, Lori Boston, Richard D. Hayes, Chris Daum, Kerrie Barry, Igor V. Grigoriev, Xiyin Wang, Fay-Wei Li, Stefan A. Rensing, Julius Ben Ari, Noa Keren, Assaf Mosquna, Andreas Holzinger, Pierre-Marc Delaux, Chi Zhang, Jinling Huang, Marek Mutwil6,, Jan De Vries, Yanbin Yin

Center for Plant Science Innovation: Faculty Publications

Zygnematophyceae are the algal sisters of land plants. Here we sequenced four genomes of filamentous Zygnematophyceae, including chromosome-scale assemblies for three strains of Zygnema circumcarinatum. We inferred traits in the ancestor of Zygnematophyceae and land plants that might have ushered in the conquest of land by plants: expanded genes for signaling cascades, environmental response, and multicellular growth. Zygnematophyceae and land plants share all the major enzymes for cell wall synthesis and remodifications, and gene gains shaped this toolkit. Co-expression network analyses uncover gene cohorts that unite environmental signaling with multicellular developmental programs. Our data shed light on a molecular …