Digital Commons Network^™

Univariate And Multivariate Approaches For Identifying Key Differential Volatile Compounds In Wedelia Trilobata Essential Oils From Four Different Locations, Tuan Ashraf Faiz Tuan Anuar, Suria Ramli, Chamroon Laosinwattana, Kamalrul Azlan Azizan

Makara Journal of Science

Geographical location is an important factor affecting the production of the volatile compounds and corresponding bioactivity of essential oil (EO). The aim of this study was to determine whether the bioactivity of Wedelia trilobata EO varies by geographical location and identify the key volatile compounds involved in bioactivity. A total of 95 volatile compounds reported in W. trilobata EOs obtained from Brazil, India, Malaysia and Thailand were retrieved from the literature, and changes and key differential volatile compounds were identified with univariate and multivariate methods. Results showed that the monoterpene hydrocarbon content of α-phellandrene and α-pinene were higher than that …

Myeloid-Derived Suppressor Cell Mitochondrial Fitness Governs Chemotherapeutic Efficacy In Hematologic Malignancies, Saeed Daneshmandi, Jee Eun Choi, Qi Yan, Cameron R. Macdonald, Manu Pandey, Mounika Goruganthu, Nathan Roberts, Prashant K. Singh, Richard M. Higashi, Andrew N. Lane, Teresa W-M Fan, Jianmin Wang, Philip L. Mccarthy, Elizabeth A. Repasky, Hemn Mohammadpour

Markey Cancer Center Faculty Publications

Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC mitochondrial fitness controls the efficacy of doxorubicin chemotherapy in a preclinical lymphoma model. Mechanistically, we show that triggering STAT3 signaling via β2-adrenergic receptor (β2-AR) activation leads to improved MDSC function through metabolic reprogram- ing, marked by sustained mitochondrial respiration and higher ATP generation which reduces AMPK signaling, altering energy metabolism. Furthermore, induced STAT3 signaling in MDSCs enhances glutamine consumption via the TCA cycle. Metabolized glutamine generates itaconate which downregulates mitochondrial reactive oxygen species via regulation of …

Digital Preservation Practices In Federal University Libraries In Southwestern Nigeria, Oladapo James Omoju Mr, Funmilola Olubunmi Omotayo Dr

Library Philosophy and Practice (e-journal)

Modern libraries are increasingly being redefined as places to get unrestricted access to information in many formats and from many sources by providing a tremendous amount of information with a variety of digital tools. The study focused on digital preservation practices in federal university libraries in Southwestern Nigeria. A survey design of the qualitative type was adopted. All federal university libraries in the region were sampled. Data was collected through interviews conducted with the heads of the Digital Preservation Units or their representatives. Data were analysed thematically. All the universities have adopted digital preservation. The libraries preserve born-digital resources, research …

An Injectable In Situ Forming Collagen/Alginate/Caso4 Composite Hydrogel For Tissue Engineering Applications: Optimization, Characterization And In Vitro Assessments, Samar A. Salim, Samar A. Salim

Nanotechnology Research Centre

In situ injectable hydrogels are effectively employed to fill irregular cavitary bone defects with initiating bone growth in targeted areas. Herein, an injectable composited hydrogel composed of collagen and alginate cross-linked in situ using different concentrations of calcium sulfate (0.15, 0.3 and 0.6%, wt./v) was synthesized. Recently, CaSO4 is frequently supported as a bone graft material for bone regeneration, owing to its biocompatibility and osteoconductive properties. Moreover, hydroxyapatite (Hap) after salinization-step by (3-Aminopropyl) triethoxysilane (APTES) was incorporated for further enhancing the osteoconductive property of injected hydrogels. All fabricated hydrogels were characterized by SEM, FTIR and XRD analyses. While physiochemical characteristics …

Recent Progress And Challenges Of Implantable Biodegradable Biosensors, Md Ashfaq Ahmed

All Publications

Implantable biosensors have evolved to the cutting-edge technology of personalized health care and provide promise for future directions in precision medicine. This is the reason why these devices stand to revolutionize our approach to health and disease management and offer insights into our bodily functions in ways that have never been possible before. This review article tries to delve into the important developments, new materials, and multifarious applications of these biosensors, along with a frank discussion on the challenges that the devices will face in their clinical deployment. In addition, techniques that have been employed for the improvement of the …

Assessing The Effectiveness Of Copper Oxide Nanoparticles (Cuo-Nps) As Larvicidal Agents Against Aedes Aegypti Larvae In A Laboratory Setup, Muhammad Ahsan Riaz, Ayesha Riaz, Muhammad Asif Mahmood, Muhammad Uzair Mukhtar, Waseem Akram, Ehtisham Arshad, Zaib Un Nisa, Beenish Ijaz, Muhammad Shahid Rasool

Journal of Bioresource Management

The control of Aedes aegypti (A. aegypti), the primary vector for dengue virus, requires effective larvicidal agents to target larvae breeding in various water sources. This study aimed to assess the effectiveness of Copper Oxide Nanoparticles (CuO-NPs) as larvicidal agents against A. aegypti larvae in a laboratory setup. Larvae were exposed to CuO-NPs at five contrasting concentrations (0, 5, 10, 20, and 30 mg/l). Twenty-five fourth instar larvae were subjected to each concentration with three replicates and one control with the same number (n=25) of larvae under optimum laboratory conditions. The larval mortality was calculated after 24 hours. …

Fostering Engagement And Learning Outcomes: A Comparative Analysis Of Ethnochemical And Stem-Based Pedagogies For Chemistry Learning In Vocational High Schools, Maulidya Husnul Khatimah, Lismi Animatul Chisbiyah

Jurnal Pendidikan Sains

In contemporary education, the perceived difficulty of learning chemistry, attributed to its abstract nature, remains a challenge for many students. This difficulty is compounded by a notable lack of alignment between chemistry concepts and students’ daily experiences, despite the inherent relevance of chemistry to their everyday phenomena. Building on previous research affirming the efficacy of ethnochemical modules in enhancing student learning and achievement, this study investigates the suitability of a STEM-based approach for chemistry education, particularly in vocational high school. The research methodology employs a literature study method, utilizing the PICO(T) framework for keyword selection. A rigorous review and analysis …

Differences In Biology Students’ Self-Regulation During Online And Offline Learning And Its Relationship To Learning Outcomes, Adi Kus Rochman Jk, Dwi Listyorini, Fatchur Rohman, Yessi Affriyenni

Jurnal Pendidikan Sains

The cultivation of self-regulatory skills holds paramount importance for individuals’ future success, particularly in the context of evolving educational modalities prompted by the Covid-19 pandemic. As learning transitions between online during the pandemic and offline post-pandemic, understanding the nuances of self-regulation becomes imperative. Thus, this study sought to achieve three objectives: (1) analyzing disparities in student self-regulation between online and offline settings, (2) examining the interplay between online and offline self-regulation, and (3) scrutinizing the relationship between self-regulation and learning outcomes. Employing a methodological approach involving questionnaire administration, interviews, and collecting academic scores data, data analysis was conducted utilizing the …

Can Argument-Driven Inquiry-Assisted Virtual Laboratory Improve Pre-Service Physics Teachers’ Mastery Concept Of Simple Harmonic Oscillation?, Yolanda Dwi Vivian Karawahenni, Sutopo Sutopo, Arif Hidayat, Maya Mustika

Jurnal Pendidikan Sains

This study endeavors to ascertain the efficacy of the Argument-Driven Inquiry (ADI)- assisted virtual laboratory learning model in enhancing the comprehension of simple harmonic oscillation concepts among pre-service physics teachers. Employing a mixed- method approach with an embedded experimental design, the investigation employs a reasoned multiple-choice instrument comprising 15 questions. Analysis of the results reveals a noteworthy 48.38% increase in the average mastery of concepts between the pre-test and post-test, yielding an N-gain value of 0.63. Statistical scrutiny through paired sample t-tests corroborates significant disparities between pre-test and post-test scores, evidenced by a tcount (16.28) exceeding the critical ttable value …

Error Analysis Of Learners’ Problem-Solving Abilities In Mathematics Courses: A Newman Error Analysis (Nea) Approach, Aprilita Ekasari, Don Jaya Putra

Jurnal Pendidikan Sains

This study endeavors to systematically discern the spectrum of learner errors manifesting in problem-solving processes within the domain of mathematics, specifically focusing on the intricacies of integration, utilizing Newman Error Analysis (NEA) as the guiding framework. The cohort under investigation comprises 14 first-year students hailing from the Department of Physics Education at Musamus University, Merauke. Employing a descriptive methodology underscored by a qualitative orientation, this research incorporates tests and interviews as primary instruments for data collection. The tests are designed to meticulously evaluate the array of errors committed by learners, as per the tenets of Newman’s model. Additionally, a subset …

Addressing Subject Heterogeneity In Time-Dependent Discrimination For Biomarker Evaluation, Xinyang Jiang, Wen Li, Ruosha Li, Jing Ning

Faculty, Staff and Student Publications

Accurate discrimination has been the central goal in identifying biomarkers for monitoring disease progression and early detection. Acknowledging the fact that discrimination accuracy of biomarkers for a time-to-event outcome often changes over time, local measures such as the time-dependent receiver operating characteristic curve and its area under the curve (AUC) are used to assess time-dependent predictive discrimination. However, such measures do not address subject heterogeneity, although the impact of covariates including demographics, disease-related characteristics, and other clinical information on the discriminatory performance of biomarkers needs to be investigated before their clinical use. We propose the covariate-specific time-dependent AUC, a measure …

Real World Clinical Experience Using Daily Intelligence-Assisted Online Adaptive Radiotherapy For Head And Neck Cancer, Philip Blumenfeld, Eduard Arbit, Robert Den, Ayman Salhab, Tal Falick Michaeli, Marc Wygoda, Yair Hillman, Raphael Pfeffer, Marcel Fang, Yael Misrati, Noam Weizman, Jon Feldman, Aron Popovtzer

Department of Radiation Oncology Faculty Papers

Background

Adaptive radiation therapy (ART) offers a dynamic approach to address structural and spatial changes that occur during radiotherapy (RT) for locally advanced head and neck cancers. The integration of daily ART with Cone-Beam CT (CBCT) imaging presents a solution to enhance the therapeutic ratio by addressing inter-fractional changes.

Methods

We evaluated the initial clinical experience of daily ART for patients with head and neck cancer using an online adaptive platform with intelligence-assisted workflows on daily CBCT. Treatment included auto-contour and structure deformation of Organs at Risk (OARs) and target structures, with adjustments by the treating physician. Two plans were …

The Effect Of Cervical Pessary On Increasing Gestational Age At Delivery In Twin Pregnancies With Asymptomatic Short Cervix: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Amir Hossein Norooznezhad, Nikan Zargarzadeh, Ali Javinani, Seyedeh Maedeh Nabavian, Shohra Qaderi, Shayan Mostafaei, Vincenzo Berghella, Yinka Oyelese, Alireza A. Shamshirsaz

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: The incidence of preterm delivery is much higher in twin pregnancies than in singletons and even higher if a short cervical length is detected in the second trimester. Studies are contradictory regarding the efficacy of a cervical pessary to decrease preterm birth in twin pregnancies and short cervical length. To conduct a systematic review and meta-analysis investigating the efficacy of cervical pessary in prolonging gestation, preventing preterm birth, and reducing adverse neonatal outcomes in twin pregnancies with an asymptomatic short cervix.

DATA SOURCES: PubMed, Scopus, Web of Science, and ClinicalTrials.org were searched for randomized controlled trials from inception to …

Simultaneous Extraction And Quantitative Analysis Of S-Methyl-L-Cysteine Sulfoxide, Sulforaphane And Glucosinolates In Cruciferous Vegetables By Liquid Chromatography Mass Spectrometry, Armaghan Shafaei, Caroline R. Hill, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Mary C. Boyce

Research outputs 2022 to 2026

Sulfur containing compounds including glucosinolates (GLS), sulforaphane (SFN) and S-methyl-L-cysteine sulfoxide (SMCSO) have been proposed to be partly responsible for the beneficial health effects of cruciferous vegetables. As such, greater understanding of their measurements within foods is important to estimate intake in humans and to inform dietary intervention studies. Herein is described a simple and sensitive method for simultaneous analysis of 20 GLS, SFN and SMCSO by liquid chromatography mass spectrometry. Analytes were effectively retained and resolved on an Xbridge C18 column. Detection can be achieved using high resolution or unit resolution mass spectrometry; the latter making the method more …

Antioxidant Properties Of Bovine Liver Protein Hydrolysates And Their Practical Application In Biphasic Systems, Betul Arslan, Youling L. Xiong, Ayla Soyer

Animal and Food Sciences Faculty Publications

BACKGROUND: The influence of protein hydrolysate produced from bovine liver protein hydrolysate (LPH) by enzymatic hydrolysis, using Alcalase/Protamex (1:1), on lipid dispersions was investigated. LPH production was optimized to maximize the antioxidant activity (at 45, 50, and 55 °C for 12, 18, and 24 h). Different concentrations of LPHs (1, 3, and 5 mg/g) were added to emulsions and to liposomes. Lipid oxidation level and particle size of the lipid dispersions were monitored for 14 days of storage at 25 °C. RESULTS: Radical scavenging activity and reducing power were the highest at 45 °C after 24 h of hydrolysis. Electrophoresis …

Transcriptional Responses Of Different Brain Cell Types To Oxygen Decline, Camille Ravel-Godreuil, Ethan R Roy, Srinivas N Puttapaka, Sanming Li, Yanyu Wang, Xiaoyi Yuan, Holger K Eltzschig, Wei Cao

Faculty, Staff and Student Publications

Brain hypoxia is associated with a wide range of physiological and clinical conditions. Although oxygen is an essential constituent of maintaining brain functions, our understanding of how specific brain cell types globally respond and adapt to decreasing oxygen conditions is incomplete. In this study, we exposed mouse primary neurons, astrocytes, and microglia to normoxia and two hypoxic conditions and obtained genome-wide transcriptional profiles of the treated cells. Analysis of differentially expressed genes under conditions of reduced oxygen revealed a canonical hypoxic response shared among different brain cell types. In addition, we observed a higher sensitivity of neurons to oxygen decline, …

Amphibious Robots Locomotion Strategies In Unstructured Complex Environments: A Review, Mohammed Rafeeq, Siti Fauziah Toha, Salmiah Ahmad, Mohd Asyraf Razib, Ahmad Syahrin Idris, Mohammad Osman Tokhi

Platform: A Journal of Engineering (PAJE)

In the previous literature, amphibious robots focused mainly on locomotion in underwater and flat land surface manoeuvring. Few amphibious robots focused on unstructured land environments. The amphibious robot designs were more emphasised in academics, leading to more work done in building amphibious robots that mimic biological amphibians, imitating the geometry and overall functionality of the amphibious robots. Developing amphibious robots with propulsive mechanisms for manoeuvring in a water environment received more attention than other functionalities like adaptability on rough natural terrain and obstacle repositioning capability. However, practical applications like reconnaissance and surveying posed challenges in the ground environment, which had …

Ornithofauna Diversity Of Tehsil Pakpattan, Punjab, Pakistan, Muhammad Amir Sial

Journal of Bioresource Management

Tehsil Pakpattan is situated in the Doab region of Punjab, Pakistan, along the Sutlej River. The present study aimed to evaluate the avian biodiversity of Tehsil Pakpattan. The study included the evaluation of species diversity, IUCN Red List status, migratory description, and feeding habits of the bird populations of Tehsil Pakpattan. Regular surveys were conducted at ten different localities in Tehsil Pakpattan, including Islam Colony, Kanipur, Farid Kot, 14 S/P, Chak Khagga, Musewal, 8 S/P, Noorpur, Green Town, and Bonga Niaz Khan, from January 2022 to April 2023. The Shannon‒Wiener diversity index value (R' = 3.41) indicated the notable diversity …

A Review On Bioremediation Of Heavy Metals And Hydrocarbons Through Plant Growth-Promoting Bacteria And Composting, Hafsa Saleem, Hadia Farooq, Rimsha Mazhar, Sadaf Shakil, Sahar Fazal

Journal of Bioresource Management

Soil is an important ecosystem component; it serves as a habitat for many microscopic organisms that play an important role in the ecosystem's maintenance and crops grown in soil. Unfortunately, human activities have adversely affected not only the environment but also the soil health. Soil has been contaminated with heavy metals hydrocarbons and hydrocarbon-based products that are affecting soil health and the growth of plants. In this review two methods of heavy metal remediation are discussed; one is the role of plant growth-promoting bacteria (PGPB) in the enhancement of phytoremediation and the other is composting. PGPB help plants to grow …

Immortality Through Obliteration: Buddhist Influences On Juche Thought, Christian Curriden

The Thetean: A Student Journal for Scholarly Historical Writing

North Korean Juche philosophy has come to be considered a quasi-state religion. Since its inception in the mid-192os as a slogan encouraging selfsufficiency and anti-Japanese struggle, it has undergone a series of changes. First, the focus of animosity changed from the Japanese to the Americans during the Korean War. During the 1960s, it morphed into a more comprehensive nationalist ideology emphasizing political independence, economic autarky, and military self-defense. With the addition of the "political-social body" concept in 1986, it evolved yet again into a quasi-religious metaphysical worldview, asserting that the leader, party, and people were all organs of an immortal …

The Smallpox Revolution, Sierra Marchand

The Thetean: A Student Journal for Scholarly Historical Writing

Samllpx was one of the most feared diseases in colonial North America during the eighteenth century. This fear was caused by "the suddenness and unpredictability of its attack, the grotesque torture of its victims, the brutality of its lethal or disfiguring outcome, and the terror that it inspired, which [made] Smallpox unique among human diseases." People who contracted the disease had a thirty to fifty percent chance of survival, and if they survived the painful illness, many victims lost their eyelashes, had permanent facial scaring and pitting, or even sometimes went blind. This made smallpox survivors the subjects of social …

The Impact Of The Gut-Brain Axis On Alzheimer’S Disease, Elissa Wakim

Best Integrated Writing

Elissa’s review for the Graduate Biomedical Review focuses on the links between the gastrointestinal tract and the brain; the gut-brain axis and the development of Alzheimer’s disease. As a student in the Microbiology and Immunology Masters Program Elissa was particularly interested in the gut microbiota and their connection to neurodegenerative disease. She tidily reviewed the literature and wrote a fascinating and compelling piece of work.

Characterizing The Polyamorous Experience Through Research, Kacey O'Harra

Best Integrated Writing

Scientific study of polyamory and the individuals who practice it has seen a sharp increase in the last decade, revealing data and subjective experiences that support their capacity to be closely intimate and fulfilling, to bolster personal development, to provide a positive and stable family environment, and to mutually strengthen the bonds of each relationship involved. Understanding the unique experiences and challenges faced by polyamorous lovers is essential for cultural competence in relational research, clinical practice, institutional regulations, and moving toward greater social acceptance. Examined here are the associated stigmas and their impacts on polyamorous individuals, the motivations people have …

Balancing The Mind: The Role Of Selective Serotonin Reuptake Inhibitors In Managing Anxiety, Olivia Mace

Best Integrated Writing

Olivia’s senior capstone review article focuses on the role of the selective serotonin reuptake inhibitor (SSRI) escitalopram in the management of anxiety. SSRIs have been successfully used to treat depression for decades, with fluoxetine (Prozac) being introduced to the US market in 1987. Recently it has been found that the SSRI escitalopram has efficacy in treating anxiety as well as depression. Olivia’s review is detailed and timely. Unmanaged anxiety and depression are common among students and this review will be of interest to students, parents and the university population in general.

The Potential Role Of Txa In Treating Brain Hemorrhage, Elijah Byrd

Best Integrated Writing

Elijah Bird’s essay provides an excellent review of the existing research and explores the promising possibilities of TXA in the treatment of brain hemorrhages.

Best Integrated Writing Spring 2024 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Kristie Mckiernan, Tracy Smith

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University. This is the first issue after a 5 year hiatus.

A Comprehensive Review On Solenostemma Argel (Del.) Hayne, An Egyptian Medicinal Plant, Essam Abdel-Sattar, Riham A. El-Shiekh

Bulletin of Faculty of Pharmacy Cairo University

Solenostemma argel (Del.) Hayne, commonly known as Arghel or Hargal, is a desert plant belonging to the family Apocynaceae. It has been used in traditional medicine in various countries, including Saudi Arabia, Egypt, Libya, Algeria, and Sudan, where it is the primary source. The review is aimed at providing a comprehensive report on Solenostemma argel (Del.) Hayne, including its botanical identification and description, geographical distribution, traditional uses, phytoconstituents, and pharmacological and toxicological properties. A professional search in the available literature was performed through several databases. The search was performed using the following keywords: Solenostemma argel, Argel, chemical structures, biological effects, …

Ameliorative Effect Of Aqueous Leaf Extract Of Cola Acuminata On Mercury Chloride- Induced Neurotoxicity In Male Wistar Rat, Ayinla Maryam T, Yakub Zaidat M., Asuku Abraham O., Muzzamil Salamat S.

Bulletin of Faculty of Pharmacy Cairo University

Ameliorative effect of aqueous leaf extract of Cola acuminata(ALECA) on mercury chloride- induced neurotoxicity in male Wistar rat was investigated. Thirty six (36) male Wistar rats weighing 120g-150g were randomly divided into six groups; group I: received 0.5ml normal saline; group II: received 5mg/kg body weight (b.w) mercury chloride (HgCl2); group III: received 5mg/kg HgCl2 +150mg/kgb.w ALECA; group IV: received 5mg/kg HgCl2 + 300mg/kg ALECA; group V: received 5mg/kg HgCl2 +50mg/kg N-acetyl cysteine (NAC); group VI: received 5mg/kg HgCl2 + 500mg/kg b.w Vitamin C. The animals were treated for 21days via oral route. The rats were subjected to open field …

Monthly Occurring, Maturation Time And Some Host Factor Effects On The Spirurine Nematode Rhabdochona (Rhabdochona) Longispicula Belous, 1965 Parasitizing Cyprinion Macrostomus (Ostiechthyes: Cyprinidae) From Greater Zab River, Samir Jawdat Bilal

Polytechnic Journal

Samples of the native fish Cyprinion macrostomus were collected monthly from three different points of Greater Zab River (Rezan, Qandil and Aski-kalak), from January to the end of December 2022. The goals of this study was to determine the prevalence, mean intensity and abundance of infected C. macrostomus with Rhabdochona (Rhabdochona) longispicula, the time and rate of parasite maturation, time of higher peak/ lower appearance of infection were studied. On other hand, effects of some host factors like sex and age were also revealed. The study showed fishes infections with the nematode Rhabdochona longispicula with a highest prevalence (42.85%) of …

Overview On Silver Nanoparticles: Properties, Preparation And Application For Cancer Therapy, Noor Mohammed Dawood, Lubna Abdalkarim Sabri

Maaen Journal for Medical Sciences

Silver nanoparticles (AgNPs) are an important product from the nanotechnology field, they have gained interest due to their distinctive physicochemical properties includes; good electrical resistance, thermal and chemical stability that largely have been influenced by size, shape, surface properties and composition of AgNPs. Additionally, AgNPs have well-known biological activity, including antimicrobial, antioxidant, anticancer, and anti-inflammation properties and are also used in biomedical devices. Recently, AgNPs have emerged as a potential drug delivery carriers, particulary for enhancing the efficacy of cancer therapeutics. The objective of this narrative review is to compare of various AgNPs preparation methods, with focus on up-to-date approaches. …