Digital Commons Network^™

Mechanisms Of Life History Trade-Offs In The Evolution Of Eusociality, Frances Katherine Hunter

All Graduate Theses and Dissertations, Fall 2023 to Present

When faced with stressors such as pathogen infection, organisms must invest energy in defense or risk death. Because resources are limited, mounting an immune response often comes at the expense of other costly activities such as reproduction. The costs of immunity are shaped by factors including behavior, nutrition, age, and evolutionary history.

Social insects (e.g., ants, bees, and wasps) offer a powerful system for studying these trade-offs because queens in these colonies appear to escape them—living long lives while reproducing prolifically. Bees, which include species that range from those which nest solitarily to those with complex social systems and many …

Domestic Cow Of Plenty: Gender And Womanhood In The Bhāgavata Purāṇa, Harshika Ajay Gupta

All Graduate Theses and Dissertations, Fall 2023 to Present

This thesis examines gender and womanhood in the Bhāgavata Purāṇa (Bhāgavata), a Sanskrit text from the 10th century CE that holds an important theological and cultural position in contemporary Hindu traditions. It decodes the Bhāgavata’s unique perspectives on the following: (1) gender, sex, sexuality, and reproduction, (2) women’s social normativity, and (3) women’s personhood and agency. This thesis argues that the Bhāgavata contains a unique theorization of gender and sex as well as a positive valuation of femininity, and that it imbues its narratives with practical resources and actions to recognize and expand the agentive capacity of women.

For scholars …

Assessing Geomorphic Change From Large Wood Additions In An Intensively Monitored Watershed, Alexander Walt

All Graduate Theses and Dissertations, Fall 2023 to Present

Rivers across the American West are under stress. Over time, human activities have decreased riparian vegetation and removed naturally occurring large wood from fallen trees and beaver dams. Overgrazing, wetland drainage, and artificial barriers like levees and berms have further changed these ecosystems, leaving behind simple channels that lack varied habitat for aquatic species.

Efforts to restore rivers have made some progress, but many projects are small in scale and focus more on reshaping the river rather than restoring the natural processes that keep it healthy. This study evaluates a different approach—Low-Tech Process-Based Restoration (LTPBR)—which works with nature to rebuild …

Cannabis: A Model Plant To Study Light-Mediated Reproductive Development, Madigan J.H. Eckels

All Graduate Theses and Dissertations, Fall 2023 to Present

Cannabis (Cannabis sativa) is a plant of increasing importance for research, medical, recreational, industrial, and agricultural purposes, but a strict legal landscape means that it was chronically understudied. Now that research institutions can utilize this plant for study, we require updated terminology to describe various cannabis flowering types that occur under ideal and non-ideal growing conditions. We introduce new flowering terminology and describe them in text and with photographs.

Plants use light as a resource to power photosynthesis, and a greater total sum of photons generally increases yield. In controlled environment agriculture where growers utilize light fixtures instead …

Effect Of Agroecological Feeding Systems Of Dairy Cattle On The Nutritional Composition Of Milk, Sree Bhavya Immadi

All Graduate Theses and Dissertations, Fall 2023 to Present

How food is produced can influence both its nutritional quality and its impact on the environment. In recent years, regenerative (agroecological) farming practices have gained attention for their potential to improve soil health, biodiversity, and the nutritional value of foods. In dairy production, these practices often involve growing more diverse forage crops, reducing soil disturbance, and relying less on monoculture-grown feed rations. However, there is still limited real-world evidence showing how these practices affect the nutritional composition of milk produced on commercial dairy farms.

This dissertation explores how regenerative feeding and feed production practices influence the nutritional quality of milk, …

Effects Of Serum And Commercial Serum-Free Media On Development Of In Vitro Produced (Ivp) Embryos In Cattle, Kyla Miller

All Graduate Theses and Dissertations, Fall 2023 to Present

Serum-containing media has been shown to increase incidence of large offspring syndrome and to alter gene expression, protein synthesis, and cell signaling. These factors together can result in increased pregnancy loss when combined with assisted reproduction technologies. However, there are very few direct comparisons of commercial serum-free media (IVF Bioscience™) and serum-containing media on both IVF and cloned embryo development in cattle. The aim of this study was to determine the role of serum in oocyte maturation and subsequent embryo development. Three culture systems, including in vitro maturation (IVM) and in vitro culture (IVC), were used in this study. Both …

Gradient Based Optimization Methods For Robust Learning And Biomedical Signal Modeling, Jarrod Mau

All Graduate Theses and Dissertations, Fall 2023 to Present

This dissertation explores how modern artificial intelligence techniques can be used to better understand complex biological data. Specifically, it develops new machine learning based methods and applies them to two important biomedical problems: analyzing brain signals and studying protein behavior.

The first part of the work introduces a new machine learning approach designed to improve how computers classify structured data. Traditional neural networks are powerful but can sometimes generalize poorly. This research proposes a method that combines the flexibility of neural networks with the reliability of ensemble techniques, leading to more robust and accurate predictions across different types of datasets. …

Exploring The Correlation Between Malnutrition And Food And Nutrition Insecurity In Inflammatory Bowel Disease, Heather Burr

All Graduate Theses and Dissertations, Fall 2023 to Present

Inflammatory Bowel Disease (IBD) may increase the risk of malnutrition because of nausea, vomiting, diarrhea and restrictive eating. In addition, patients with IBD may experience food and nutrition insecurity. Therefore, we conducted an online survey to assess risk of malnutrition and food and nutrition insecurity among adult patients with IBD in outpatient and community settings. Patients were recruited between July and December 2025, aiming to reach adults in the Rocky Mountain Region diagnosed with IBD. Data collected included demographics, health-related factors, risk of nutrition insecurity, risk of food insecurity, and barriers and facilitators to dietary management of IBD.

Fifty-seven patients …

Comparative Fatigue Analysis Of Cf-Pla Metamaterial Bone Plates For Orthopaedic Fixation, Ani Daniel, Hamed Bakhtiari, Barun K. Das, Muhammad Aamir, Majid Tolouei-Rad

Research outputs 2022 to 2026

Bone plates are widely used in orthopaedic surgery to stabilise fractured bones and support healing following traumatic injuries or osteotomies. However, conventional metallic bone plates suffer from stress shielding and stiffness mismatch with bone, which can hinder optimal healing. Additive manufacturing enables the incorporation of novel metamaterial architectures into polymer-based implants to enhance mechanical properties. The fatigue behaviour of these implants during the healing period is critical to ensuring their structural integrity and long-term performance. In this study, the compressive fatigue performance of fused deposition modelling (FDM)-printed carbon fibre-reinforced polylactic acid (CF-PLA) bone plates were investigated. Four metamaterial structures—tetrachiral, re-entrant, …

Targeted Epigenome Sequencing Of Eosinophils Reveals Cpg Sites And Regulatory Variants Associated With Asthma., Rébecca Dionne-Gagné, Anne-Marie Madore, Anne-Marie Boucher-Lafleur, Tomi Pastinen, Catherine Laprise

Manuscripts, Articles, Book Chapters and Other Papers

Eosinophils are pro-inflammatory cells that play a central role in asthmatic inflammation. However, few studies have examined their methylation profiles in asthma, all relying on microarray-based approaches. Here, an epigenome-wide association study in 183 purified eosinophil samples from the Saguenay-Lac-Saint-Jean asthma family cohort was performed using a custom sequencing panel targeting 4,609,564 CpGs in immune regulatory regions. Two CpG sites in MAEA and SLC9A2 genes, known to be involved in immune function, were significantly associated with asthma, while five additional sites showed suggestive associations. Integration with genotype data (7,829,429 variants) and expression counts (17,513 genes) identified significant quantitative trait loci-mediated …

Treatment Of Haemophilia A Without Inhibitors: Real-World Treatment Patterns And Clinical Outcomes In The Us., Allison P. Wheeler, Lauren Amos Md, Shveta Gupta, Sylvie Bozzi, Gandarvaka Miles, Kalyani Hawaldar, Andrew Wilson, Gillian Hanson, Emily Cibelli, Amanda Wilson, Siddhi Umarje, Anne-Laure Tardy, Jennifer Dumont, Graham Neill, Alix Arnaud

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Despite available prophylactic therapies for haemophilia A, breakthrough bleeding and consequent pain and joint damage still occur.

AIM: To provide insights into the unmet treatment needs of people with moderate-to-severe haemophilia A in the US.

METHODS: For this descriptive, observational cohort study, eligible participants diagnosed with moderate-to-severe haemophilia A were enrolled in the PicnicHealth database on or before 3 October 2022. Three patient groups were established to identify: (1) treatment patterns; (2) clinical outcomes by therapy class (standard half-life [SHL] factor VIII [FVIII]; extended half-life FVIII [EHL]; emicizumab); (3) health-related quality of life (HRQoL) using the Patient-Reported Outcomes Measuring …

Functional Heterogeneity In Trophoblast Stem Cells Derived From Recurrent Pregnancy Loss Products Of Conception., Qi Fu, Keisuke Kozai, Xingrao Ke, Joe Varberg, Sheng Xia, Ashley S. Howard, Michael Lydic, Kristin Holoch, Courtney Marsh, Elin Grundberg, Kaela Varberg

Manuscripts, Articles, Book Chapters and Other Papers

Recurrent pregnancy loss (RPL), defined as two or more consecutive miscarriages, affects 1-5% of couples attempting to conceive and most frequently occurs between 6 and 8 weeks of gestation, coinciding with critical stages of placental development. Despite this temporal association, placental contributions to RPL pathogenesis remain poorly understood. We hypothesized that trophoblast lineage development, including extravillous trophoblast (EVT) and syncytiotrophoblast (STB) differentiation, are disrupted in RPL. To test this hypothesis, we established and functionally characterized human trophoblast stem (TS) cell lines derived from products of conception (POC) obtained from consenting idiopathic RPL cases. Four TS cell lines were successfully derived …

Gestational Diabetes And Social Determinants Of Health In Black Women, Darianne Greenwood

Capstone Experience: Master of Public Health

Gestational Diabetes Mellitus (GDM) poses significant health risks, specifically increasing the risk of developing Type 2 Diabetes post-delivery, as well as increasing the risk of adverse neonatal and maternal outcomes. Black women, in particular, experience disproportionately higher rates of GDM incidence, severity, and complications in comparison to White women. Biological factors alone do not account for these disparities, necessitating a deeper examination into how systemic factors, particularly the social environment, influence these inequitable health outcomes. The purpose of this comprehensive literature review is to answer the question: “How do the Social Determinants of Health (SDoH), such as residential segregation, food …

Ecosystem Service And Natural Capital Indicator Dataset For Plymouth Sound National Marine Park (Uk): Observed And Aspirational Indicators With Evaluation Criteria, Kizzy Beaumont, Matthew Ashley, Tom Mullier, Sian Rees

Faculty of Science and Engineering Datasets

This dataset provides a comprehensive set of ecosystem service (ES) and natural capital (NC) indicators for the Plymouth Sound National Marine Park (UK), developed through a co-evaluation of monitoring systems for transformative ocean governance. A total of 109 indicators are identified and mapped across the natural capital logic chain (asset state, pressures, ecosystem service flows, and benefits), drawing on existing datasets, literature, and stakeholder workshop input. Each indicator includes metadata, evaluation against standardised quality criteria, and assessment of strengths and limitations. The dataset includes both current indicators and aspirational indicators, highlighting gaps in monitoring and opportunities for future development. It …

In-Vitro Testing Of Light Wavelength To Detect Clots In Neonatal Extracorporeal Membrane Oxygenation Circuitry, Amanda Holmes

Dissertations and Theses (Open Access)

Background: Neonates requiring extracorporeal membrane oxygenation (ECMO) are at high risk for thrombotic complications, which contribute substantially to morbidity and mortality. Current circuit surveillance methods rely on intermittent visual inspection and indirect laboratory markers, both of which often detect thrombosis only after clinically significant progression. Optical approaches offer a non-invasive alternative for earlier clot visualization, yet the influence of illumination wavelength on detection performance under realistic ECMO conditions remains incompletely characterized.

Methods: This study evaluated wavelength-dependent clot detection performance in a controlled in-vitro neonatal ECMO circuit model using a portable imaging prototype designed to emulate bedside workflow. Twelve independent ECMO …

Electrical Resilience In Water Treatment Plants: An Extreme Weather And Lightning Protection Study, Genesis Martinez

Theses and Dissertations

Water treatment plants (WTPs) are vital infrastructure systems that depend on sensitive electrical, electronic, and control equipment to ensure the continuous supply of safe drinking water and effective wastewater treatment. As global temperatures rise and climate change accelerates, the frequency and intensity of extreme weather events—such as hurricanes, flooding, and increased lightning activity—are becoming more pronounced. These events pose significant risks to the electrical resilience of water treatment facilities, often leading to power outages, equipment failures, grid instability, and prolonged service disruptions. This report explores the impacts of extreme weather, with a particular focus on lightning and electrical surges, on …

Modeling Causal Interactions Across Brain Functional Systems For Population-Specific Disease Analysis, Alissen Moreno

Theses and Dissertations

Functional brain connectivity provides critical insight into neural mechanisms underlying neurodegenerative and affective disorders. Traditional neuroimaging studies rely on undirected or region-specific connectivity measures developed predominantly using racially homogeneous cohorts, limiting fairness and generalizability across diverse populations.

We propose a population-aware framework modeling directed causal interactions across large-scale brain functional subnetworks. Resting-state fMRI data from the HABS-HD cohort were used to construct subject-level causal connectivity matrices via ICA-LiNGAM, aggregated into interpretable system-level hyper-connectomes representing interactions among eleven canonical brain subsystems. These features trained nonlinear models for Alzheimer’s disease stage classification and trait worry prediction.

Results demonstrate that MLP models outperform …

Low-Vision Students’ Experiences With And Suggestions To Improve Desktop Virtual Reality: A Qualitative Study, Tanveer Mansur Syed

Theses and Dissertations

Visually impaired students have faced challenges in the field of education, particularly in science education. Not surprisingly, the unemployment rate for working-age visually impaired people has been above 70%. This persists despite federal laws to support the education and employment of visually impaired people,

Virtual Reality (VR) technology has evolved for several decades. Its use has proliferated in areas that include education. Today, VR science lab simulations are presented as a cost-effective alternative to traditional science labs. Research shows these to be viable substitutes to traditional science labs without a significant drop in learning outcomes. However, this researcher was unable …

Enhancing Walleye (Ogaa) Recruitment: Evaluating Assisted Reproduction As A Mitigation Strategy, Douglass Keiser

Biology Graduate Theses

Over the past several decades, cold- and cool-water fish populations across the Upper Midwest, including Minnesota and Wisconsin, have shown troubling signs of decline. Among the most affected is the walleye/Ogaa (Sander vitreus), a species deeply embedded in the ecological balance, cultural identity, and economic vitality of the region, and central to the lifeways, treaty-reserved rights, and resource stewardship of Tribal Nations, including Ojibwe communities across the Upper Midwest. Despite ongoing stocking efforts and harvest regulations, many lake systems have experienced persistent declines in natural recruitment, prompting resource agencies to investigate the underlying causes. One such system is …

Biodiversity Risk And Firm Valuation: Regional Heterogeneity And Value-Chain Exposure In Global Capital Markets, Madelein Wentzel

Doctoral Dissertations (DBA)

This study examines whether biodiversity-related risks are priced in global equity markets and whether that pricing varies across regions, using a cross-sectional sample of more than 10,000 globally listed firms with biodiversity and financial data drawn from the fourth quarter of 2025. Consistent with a regional heterogeneity hypothesis, the results show that biodiversity risk is significantly negatively associated with firm valuation in developed markets such as the United States and OECD countries, while the relationship is weaker, insignificant, or even positive in certain emerging regions including Latin America and the Middle East and Africa. The analysis further distinguishes between value-chain …

Evaluating Management Strategies And Technology To Improve Grazing Efficiency, Thomas E. Aquino

Department of Animal Science: Dissertations, Theses, and Student Research

Increasing land costs and labor constraints continue to challenge beef producers. More intensive practices can increase harvest efficiency; however, many producers are deterred from implementing them due to increased labor and management considerations. Virtual fencing (VF) may provide a reduced labor alternative to traditional fencing for managing intensive grazing. This dissertation evaluated management strategies and VF technology to improve grazing efficiency of stocker cattle systems. In Experiment 1, VF was used to effectively manage groups of steers grazing in adjacent paddocks separated by only virtual boundaries. There was no difference in VF containment (99%) when steers were grazing co-fenced, with …

Exploring The Experiences Of Adult Children Of Parents With Addiction: A Qualitative Support Group Approach, Brooke Stanton

Undergraduate Honors Capstone Projects

Adult children of parents with addiction often grow up having to navigate emotional instability, inconsistent caregiving, and long-term relational impacts that continue into adulthood. Many individuals report limited access to supportive care and spaces where they can share their stories. This capstone project addresses the gap by designing and facilitating a support group specifically for adult children of parents to build connection and healing. Through this qualitative study, participant feedback, and analysis, this project examines how structured peer support can create meaningful change for this population. The following paper outlines the development of the group, the theoretical foundations that guided …

A Mixed Methods Analysis On The Effect Of Active Learning On Extraneous Cognitive Load Within Undergraduate Statistics Courses, Michelle Brady Rich

All Graduate Theses and Dissertations, Fall 2023 to Present

Students enrolled in college-level statistics courses often lack the foundational skills of statistical concepts which can potentially lead to increased mental load. Additionally, the curricula within undergraduate classes often focus on traditional theory with little student exploration or participation. This combination of increased mental load and passive lectures can be explored through the Cognitive Load Theory (CLT). CLT examines how new information enters the limited capacity of an individual’s working memory and how exceeding this capacity affects the ability to transfer the information to long-term memory. This research focused on the extraneous cognitive load, or the load imposed by the …

Modeling Water Quality And Cyanobacteria Blooms In St. Lucie Estuary, Florida, Mohmmad Masudur Rahman

Electronic Theses and Dissertations

The St. Lucie Estuary (SLE) on Florida’s east coast is vital for diverse aquatic life and provides essential services to local communities. However, the estuary’s health is threatened by water quality deterioration due to nutrient-driven phytoplankton blooms, particularly cyanobacteria, which have increased in frequency over recent decades. These blooms may worsen water quality by reducing dissolved oxygen, altering pH, and increasing turbidity. Moreover, some phytoplankton species, including Microcystis aeruginosa, a freshwater cyanobacteria species, produce harmful toxins, posing risks to both marine aquatic life and human health in this area. Primary nutrient sources in this estuary include watershed freshwater discharges, …

Factors Associated With Postpartum Depression Symptoms Following Antepartum Hospitalization, Alison N Goulding, Daniel Palacios, Sukru Aras, Hu Chen, Sasidhar Pasupuleti, Marika Toscano, Nicole Cirino, Israel C Christie, Zhandong Liu, Emily S Miller, Terri L Fletcher

Duncan NRI Faculty and Staff Publications

Background: Hospitalized antepartum patients are at increased risk for postpartum depression (PPD). Developing approaches to identify those at highest risk for PPD would enable timely and targeted intervention.

Objective: We aimed to identify factors associated with the development of PPD symptoms in hospitalized antepartum patients and to assess their predictive utility.

Study design: This retrospective cohort study included pregnant individuals hospitalized in a regional referral center due to medical or obstetric complications between 2012 and 2025. Data were extracted from the electronic health record, including demographics, medical and obstetric history, hospitalization characteristics, and postpartum Edinburgh Postnatal Depression Scale (EPDS) scores …

Low-Abundance And Fragmentary Helicobacter Pylori Dna Detected In Phenotypically Negative Gastric Biopsies Using Targeted Sequencing, Fabien Mbaya-Tshibangu, Alain Cimuanga-Mukanya, Evariste Tshibangu-Kabamba, Nadine Kayiba-Kalenda, Tressy Kalenga-Ngomba, Patrick Ngoma-Kisoko, Gunturu Revathi, Junko Akada, Benoît Mbiya-Mukinayi, Augustin Tshibaka Kabongo

Pathology, East Africa

Accurate detection and monitoring of antimicrobial resistance (AMR) in Helicobacter pylori mainly rely on phenotypic methods and culture, which can sometimes fail when bacterial load is low or after recent treatment. We investigated whether gastric biopsies classified as H. pylori-negative by standard diagnostic techniques still contain detectable bacterial DNA, including regions linked to AMR, and assessed whether selected DNA fragments can mediate allelic exchange in vitro. Gastric biopsies from 46 dyspeptic patients in the Democratic Republic of the Congo (including 23 phenotypically positive and 23 phenotypically negative individuals) were analyzed using long-read amplicon sequencing of seven resistance-associated loci, selective whole-genome …

Pulse Wave Velocity In Atrial Fibrillation: A Scoping Review Of Clinical Relevance, Oren G. Nedjar, Zaneh Kahook, Syed Maaz Shah, Christos G. Mihos, Marc M. Kesselman

Student Publications

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with high morbidity, mortality, and healthcare burden. Arterial stiffness (AS) alters cardiac loading conditions and contributes to ventricular arterial uncoupling (VAC), diastolic dysfunction, and atrial remodeling. Pulse wave velocity (PWV) is the standard noninvasive measure of AS, but its role across the spectrum of AF has not been clearly defined. This scoping review assessed the existing literature on PWV and AF, with attention to disease onset, clinical characteristics, progression, treatment response, and outcomes. A scoping review was conducted following Preferred Reporting Items for Systematic reviews and Meta-Analyses …

2-Aminobutyrate Mediates The Impact Of Air Pollution On Blood Biomarkers Of Alzheimer’S Disease, Anum Saeed, Chris Mckennan, Jane E Clougherty, Peidi Zhou, Sheila Tripathy, Ellen J Kinnee, Jiaxuan Duan, Kevin Kip, Xuemei Zeng, Victor Villemagne, Tharick Pascoal, Mark Mapstone, Eric A Whitsel, Oscar I Lopez, Christie Ballantyne, Thomas K Karikari, Bing Yu, Steven Reis, Annie Cohen

Faculty, Staff and Students Publications

Introduction: We examined the impact of mid-life metabolites on late-life Alzheimer's disease (AD) plasma biomarkers and whether these metabolites mediate air pollution effects.

Methods: In the Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) cohort, we applied high-dimensional regression and meditation models, adjusting for observed and latent confounders, with replication in the Atherosclerosis Risk in Communities (ARIC) study. Exposures included mid-life fine particulate matter (PM2.5), black carbon, metals, and metabolites. Outcomes were: late-life plasma p-tau(181, 217, and 231) and amyloid beta 42/40 (Simoa assays).

Results: In the Heart SCORE study, seven lipid- and amnio acid-pathway metabolites measured in mid-life were …

A Smoking-Related Plasma Protein Score And Smoking-Related Cancer Risk And Mortality In The Atherosclerosis Risk In Communities Study, Meng Ru, Christopher Douville, Aghiles Guenoun, Hana Zahed, Christie M Ballantyne, Kenneth R Butler, Josef Coresh, David J Couper, Panagis Galiatsatos, Marc J Gunter, Ron C Hoogeveen, Mattias Johansson, Corinne E Joshu, P Martijn Kolijn, Christina M Lill, Jiayun Lu, Michael T Marrone, Giovanna Masala, David C Muller, Anna E Prizment, Raul Zamora-Ros, Nilanjan Chatterjee, Adrienne Tin, Elizabeth A Platz

Faculty, Staff and Students Publications

Background: Self-reported smoking may not fully capture individualized risk of smoking-related cancer, but circulating proteins may reflect biological consequences of smoking. Thus, we developed a score based on smoking-related proteins and evaluated its association with smoking-related cancer.

Methods: This prospective cohort study included 10 563 participants aged 47-70 years in the Atherosclerosis Risk in Communities study. Plasma proteins were measured using the SomaScan Platform (SomaLogic Operating Co, Inc). The score was constructed from proteins associated with current smoking, pack-years, or recent quitting identified by linear regression and elastic net regression. Cox regression was used to estimate adjusted hazard ratios and …

Fructose: Metabolic Signal And Modern Hazard, Richard J Johnson, Miguel A Lanaspa, Dean R Tolan, Marcus D Goncalves, Samir Softic, Kimber L Stanhope, Laura G Sánchez-Lozada, Mark A Herman, Joshua D Rabinowitz

Faculty, Staff and Students Publications

There is much interest in the role of sweeteners such as table sugar (sucrose) and high-fructose corn syrup in obesity and metabolic disease. Both sweeteners consist of glucose and fructose, two six-carbon isomeric sugars. Whereas glucose ingestion may promote obesity through its effects to stimulate insulin secretion, fructose has unique metabolic effects that promote triglyceride synthesis and fat accumulation. These effects arise from fructose's well-known role as a signal of metabolic plenty. Under modern conditions of overnutrition, chronic excess fructose drives features of metabolic syndrome. Emerging evidence further links fructose to cancer and dementia. Here we review the biochemical, molecular …