Digital Commons Network^™

Lived Experiences Of Nurses Caring For Persons With Mental Illnesses And Chronic Health Conditions, Luwieth Bolt

Walden Dissertations and Doctoral Studies

No abstract provided.

Section 112(A) Strife At The Federal Circuit: A Call For Congressional Amendment To Save The Genus Claim And Preserve Patent Protection In The Biological Arts, James R. Vancamp Jr.

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Table Of Contents - Vol. 48, No. 2 2024

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Cardiogpt: An Ecg Interpretation Generation Model, Guohua Fu, Jianwei Zheng, Islam Abudayyeh, Chizobam Ani, Cyril Rakovski, Louis Ehwerhemuepha, Hongxia Lu, Yongjuan Guo, Shenglin Liu, Huimin Chu, Bing Yang

Mathematics, Physics, and Computer Science Faculty Articles and Research

Numerous supervised learning models aimed at classifying 12-lead electrocardiograms into different groups have shown impressive performance by utilizing deep learning algorithms. However, few studies are dedicated to applying the Generative Pre-trained Transformer (GPT) model in interpreting electrocardiogram (ECG) using natural language. Thus, we are pioneering the exploration of this uncharted territory by employing the CardioGPT model to tackle this challenge. We used a dataset of ECGs (standard 10s, 12-channel format) from adult patients, with 60 distinct rhythms or conduction abnormalities annotated by board-certified, actively practicing cardiologists. The ECGs were collected from The First Affiliated Hospital of Ningbo University and Shanghai …

Health Factors Associated With Development And Severity Of Poststroke Dysphagia: An Epidemiological Investigation, Felipe De Los Rios La Rosa

All Publications

Background: Dysphagia after stroke is common and can impact morbidity and death. The purpose of this population-based study was to determine specific epidemiological and health risk factors that impact development of dysphagia after acute stroke.

Methods and results: Ischemic and hemorrhagic stroke cases from 2010 and 2015 were identified via chart review from the GCNKSS (Greater Cincinnati Northern Kentucky Stroke Study), a representative sample of ≈1.3 million adults from southwestern Ohio and northern Kentucky. Dysphagia status was determined on the basis of clinical assessments and necessity for alternative access to nutrition via nasogastric or percutaneous endoscopic gastrostomy tube placement. Comparisons …

The Experience Of Organizational Leaders With Decision-Making In A Crisis, Leigh E. Richardson

Walden Dissertations and Doctoral Studies

No abstract provided.

Foster Parents’ Views Regarding Lack Of Attachment In Children In Foster Care, Ronease Yvette Thompson

Walden Dissertations and Doctoral Studies

No abstract provided.

Synthesis And Characterization Of Titanium Nitride–Carbon Composites And Their Use In Lithium-Ion Batteries, Helia M. Morales Ramirez, Horacio Vieyra, David A. Sanchez, Elizabeth M. Fletes, Michael Odlyzko, Timothy P. Lodge, Victoria Padilla-Gainza, Mataz Alcoutlabi, Jason Parsons

Mechanical Engineering Faculty Publications

This work focuses on the synthesis of titanium nitride–carbon (TiN–carbon) composites by the thermal decomposition of a titanyl phthalocyanine (TiN(TD)) precursor into TiN. The synthesis of TiN was also performed using the sol-gel method (TiN(SG)) of an alkoxide/urea. The structure and morphology of the TiN–carbon and its precursors were characterized by XRD, FTIR, SEM, TEM, EDS, and XPS. The FTIR results confirmed the presence of the titanium phthalocyanine (TiOPC) complex, while the XRD data corroborated the decomposition of TiOPC into TiN. The resultant TiN exhibited a cubic structure with the FM3-M lattice, aligning with the crystal system of the synthesized …

Association Of Multiple Metabolic And Cardiovascular Markers With The Risk Of Cognitive Decline And Mortality In Adults With Alzheimer’S Disease And Ad-Related Dementia Or Cognitive Decline: A Prospective Cohort Study, Longjian Liu, Edward Gracely, Xiaopeng Zhao, Gediminas Gliebus, Nathalie May, Stella Volpe, Jingyi Shi, Rose Ann Dimaria-Ghalili, Howard Eisen

Division of Cardiology Faculty Papers

BACKGROUND AND OBJECTIVES: There is a scarcity of data stemming from large-scale epidemiological longitudinal studies focusing on potentially preventable and controllable risk factors for Alzheimer's disease (AD) and AD-related dementia (ADRD). This study aimed to examine the effect of multiple metabolic factors and cardiovascular disorders on the risk of cognitive decline and AD/ADRD.

METHODS: We analyzed a cohort of 6,440 participants aged 45-84 years at baseline. Multiple metabolic and cardiovascular disorder factors included the five components of the metabolic syndrome [waist circumference, high blood pressure (HBP), elevated glucose and triglyceride (TG) concentrations, and reduced high-density lipoprotein cholesterol (HDL-C) concentrations], C-reactive …

Rate Of Latine Caregiver Involvement In The Well-Being Promotion Program Using Culturally And Linguistically Responsive Communication Practices, Nicole G. Pacateque Rodriguez

USF Tampa Graduate Theses and Dissertations

Latine and Hispanic youth tend to have higher rates of mental health disturbances in school compared to non-Latine youth, yet they are less likely to receive support (Alegría et al., 2008). Additionally, Latine families are more likely to terminate treatment for youth early due to negative stigma, lack of culturally appropriate mental health care, racial and ethnic discrimination, and linguistic and cultural barriers involving care (Kapke & Gerdes, 2016). Best practices in school-based mental health services often involve including caregivers in care (Hoover et al., 2019) as it can benefit outcomes of treatment for the child (Richards et al., 2007). …

Alterations In Serum Thiol-Disulfide Homeostasis And Ischemia-Modified Albumin Concentrations In Clinical Canine Parvoviral Enteritis, Yasi̇n Şenel, Osman Safa Terzi̇, Erdal Kara, Özcan Erel, Sali̇m Neşeli̇oğlu, Ebubeki̇r Ceylan

Turkish Journal of Veterinary & Animal Sciences

Monitoring biomarkers related to inflammation and oxidative stress is critical in dogs because parvovirus causes both inflammatory and antioxidant alterations. The aim of this study was to investigate inflammatory and antioxidant changes caused by canine parvoviral enteritis to better understand the oxidative stress process related to this disease. Thus, the total thiol, native thiol, disulfide, and ischemia-modified albumin levels of Canine parvovirus infected symptomatic puppies and healthy puppies were examined. Using the results of complete blood counts, the blood serum thiol-disulfide homeostasis and ischemia modified albumin levels of the puppies with Canine parvoviral enteritis (n = 65) and the healthy …

Antigen-Clustered Nanovaccine Achieves Long-Term Tumor Remission By Promoting B/Cd 4 T Cell Crosstalk, Chengyi Li, Ryan Clauson, Luke F Bugada, Fang Ke, Bing He, Zhixin Yu, Hongwei Chen, Binyamin Jacobovitz, Hongxiang Hu, Polina Chuikov, Brett Dallas Hill, Syed M Rizvi, Yudong Song, Kai Sun, Pasieka Axenov, Daniel Huynh, Xinyi Wang, Lana Garmire, Yu Leo Lei, Irina Grigorova, Fei Wen, Marilia Cascalho, Wei Gao, Duxin Sun

Faculty, Staff and Student Publications

Current cancer vaccines using T cell epitopes activate antitumor T cell immunity through dendritic cell/macrophage-mediated antigen presentation, but they lack the ability to promote B/CD4 T cell crosstalk, limiting their anticancer efficacy. We developed antigen-clustered nanovaccine (ACNVax) to achieve long-term tumor remission by promoting B/CD4 T cell crosstalk. The topographic features of ACNVax were achieved using an iron nanoparticle core attached with an optimal number of gold nanoparticles, where the clusters of HER2 B/CD4 T cell epitopes were conjugated on the gold surface with an optimal intercluster distance of 5-10 nm. ACNVax effectively trafficked to lymph nodes and cross-linked with …

Targeting Branched N-Glycans And Fucosylation Sensitizes Ovarian Tumors To Immune Checkpoint Blockade, Hao Nie, Pratima Saini, Taito Miyamoto, Liping Liao, Rafal J Zielinski, Heng Liu, Wei Zhou, Chen Wang, Brennah Murphy, Martina Towers, Tyler Yang, Yuan Qi, Toshitha Kannan, Andrew Kossenkov, Hiroaki Tateno, Daniel T Claiborne, Nan Zhang, Mohamed Abdel-Mohsen, Rugang Zhang

Faculty, Staff and Student Publications

Aberrant glycosylation is a crucial strategy employed by cancer cells to evade cellular immunity. However, it's unclear whether homologous recombination (HR) status-dependent glycosylation can be therapeutically explored. Here, we show that the inhibition of branched N-glycans sensitizes HR-proficient, but not HR-deficient, epithelial ovarian cancers (EOCs) to immune checkpoint blockade (ICB). In contrast to fucosylation whose inhibition sensitizes EOCs to anti-PD-L1 immunotherapy regardless of HR-status, we observe an enrichment of branched N-glycans on HR-proficient compared to HR-deficient EOCs. Mechanistically, BRCA1/2 transcriptionally promotes the expression of MGAT5, the enzyme responsible for catalyzing branched N-glycans. The branched N-glycans on HR-proficient tumors augment their …

Ai Is A Viable Alternative To High Throughput Screening: A 318-Target Study, The Atomwise Aims Program

Faculty, Staff and Student Publications

High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, …

Can We Go Wrong With Getting Strong?, Myles Whitbread-Jordan

South West Clinical School Journal

#400WORDS: KNOWLEDGE + ACTION

A Compendium Of Multi-Omics Data Illuminating Host Responses To Lethal Human Virus Infections, Amie J Eisfeld, Larissa B Thackray, Qing Tan, Michael S Diamond, Et Al.

2020-Current year OA Pubs

Human infections caused by viral pathogens trigger a complex gamut of host responses that limit disease, resolve infection, generate immunity, and contribute to severe disease or death. Here, we present experimental methods and multi-omics data capture approaches representing the global host response to infection generated from 45 individual experiments involving human viruses from the Orthomyxoviridae, Filoviridae, Flaviviridae, and Coronaviridae families. Analogous experimental designs were implemented across human or mouse host model systems, longitudinal samples were collected over defined time courses, and global multi-omics data (transcriptomics, proteomics, metabolomics, and lipidomics) were acquired by microarray, RNA sequencing, or mass spectrometry analyses. For …

Health Factors Associated With Development And Severity Of Poststroke Dysphagia: An Epidemiological Investigation, Brittany N Krekeler, Opeolu Adeoye, Et Al.

2020-Current year OA Pubs

BACKGROUND: Dysphagia after stroke is common and can impact morbidity and death. The purpose of this population-based study was to determine specific epidemiological and health risk factors that impact development of dysphagia after acute stroke.

METHODS AND RESULTS: Ischemic and hemorrhagic stroke cases from 2010 and 2015 were identified via chart review from the GCNKSS (Greater Cincinnati Northern Kentucky Stroke Study), a representative sample of ≈1.3 million adults from southwestern Ohio and northern Kentucky. Dysphagia status was determined on the basis of clinical assessments and necessity for alternative access to nutrition via nasogastric or percutaneous endoscopic gastrostomy tube placement. Comparisons …

Effects Of Music Instruction For 3-4-Year-Old Children On Cognitive Development And Spatial Skills, Veronica Perez Espinosa

LSU Master's Theses

The impact of music instruction on child cognitive development has been examined by researchers in many contexts, but not as often in very young children. The purpose of the present study was to investigate the effects of music instruction on the spatial and cognitive skills of preschool children ages 3-4. Participants in the study were 68 three- to four-year-old students who received weekly music instruction at a private school in South Louisiana. Of the 68 participants, and using a quasi-experimental design, 30 students in three intact classes were randomly assigned to receive a movement song treatment and the other 38 …

Early Screening Of Colorectal Cancer Using Feature Engineering With Artificial Intelligence-Enhanced Analysis Of Nanoscale Chromatin Modifications, Andrew Chang, Sravya Prabhala, Ali Daneshkhah, Jianan Lin, Hariharan Subramanian, Hemant Kumar Roy, Vadim Backman

Faculty, Staff and Students Publications

Colonoscopy is accurate but inefficient for colorectal cancer (CRC) prevention due to the low (~ 7 to 8%) prevalence of target lesions, advanced adenomas. We leveraged rectal mucosa to identify patients who harbor CRC field carcinogenesis by evaluating chromatin 3D architecture. Supranucleosomal disordered chromatin chains (~ 5 to 20 nm, ~1 kbp) fold into chromatin packing domains (~ 100 to 200 nm, ~ 100 to 1000 kbp). In turn, the fractal-like conformation of DNA within chromatin domains and the folding of the genome into packing domains has been shown to influence multiple facets of gene transcription, including the transcriptional plasticity …

Cardiometabolic Characteristics Of People With Metabolically Healthy And Unhealthy Obesity, Max C Petersen, Gordon I Smith, Hector H Palacios, Sarah S Farabi, Mihoko Yoshino, Jun Yoshino, Kevin Cho, Victor G Davila-Roman, Ruteja A Barve, Jinsheng Yu, Jennifer H Stern, Bruce W Patterson, Gary J Patti, Samuel Klein, Et Al.

2020-Current year OA Pubs

There is considerable heterogeneity in the cardiometabolic abnormalities associated with obesity. We evaluated multi-organ system metabolic function in 20 adults with metabolically healthy obesity (MHO; normal fasting glucose and triglycerides, oral glucose tolerance, intrahepatic triglyceride content, and whole-body insulin sensitivity), 20 adults with metabolically unhealthy obesity (MUO; prediabetes, hepatic steatosis, and whole-body insulin resistance), and 15 adults who were metabolically healthy lean. Compared with MUO, people with MHO had (1) altered skeletal muscle biology (decreased ceramide content and increased expression of genes involved in BCAA catabolism and mitochondrial structure/function); (2) altered adipose tissue biology (decreased expression of genes involved in …

Nfĸb Signaling Drives Myocardial Injury Via Ccr2+ Macrophages In A Preclinical Model Of Arrhythmogenic Cardiomyopathy, Stephen P. Chelko, Vinay R. Penna, Morgan Engel, Emily A. Shiel, Ann M. Centner, Waleed Farra, Elisa N. Cannon, Maicon Landim-Vieira, Niccole Schaible, Kory Lavine, Jeffrey E. Saffitz

2020-Current year OA Pubs

Nuclear factor κ-B (NFκB) is activated in iPSC-cardiac myocytes from patients with arrhythmogenic cardiomyopathy (ACM) under basal conditions, and inhibition of NFκB signaling prevents disease in Dsg2mut/mut mice, a robust mouse model of ACM. Here, we used genetic approaches and single-cell RNA-Seq to define the contributions of immune signaling in cardiac myocytes and macrophages in the natural progression of ACM using Dsg2mut/mut mice. We found that NFκB signaling in cardiac myocytes drives myocardial injury, contractile dysfunction, and arrhythmias in Dsg2mut/mut mice. NFκB signaling in cardiac myocytes mobilizes macrophages expressing C-C motif chemokine receptor-2 (CCR2+ cells) to affected areas within the …

In Silico Identification Of Small Molecule Agonist Binding Sites On Kcc2, Kenyon Mitchell, Alfred Amendolara, Ruth Hunter, Jaden Miner, Andrew Payne

Annual Research Symposium

Purpose: Potassium-Chloride Cotransporter 2 (KCC2) is a neuronal membrane protein specific to the central nervous system. It is responsible for removing Cl- ions from the intracellular space, maintaining a normal Cl- gradient essential for proper function at inhibitory synapses. Dysregulation causes an upward shift in the Cl- reversal potential resulting in a hyperexcitable state of the postsynaptic neuron. Existing literature indicates that KCC2 may be involved in the addiction pathway of a variety of drugs of abuse, including opioids and alcohol. This makes KCC2 an attractive potential drug target when treating substance use disorders. A novel direct KCC2 agonist, VU0500469, …

Weight Bias In Workforce, Nadia Mazinani, Nakiya Cortijo

Diversity Summit

No abstract provided.

The Diversity Round Table Discussions Joins The 2024 Diversity Summit: Legislative Update And Bedi, Elizabeth Swann

Diversity Summit

No abstract provided.

Avoiding The Pitfalls In Administrative Record Review Cases, Kim Wilson, Brian Brammer

Public Land & Resources Law Review

No abstract provided.

Reactive Chlorine Species Reversibly Inhibit Dnab Protein Splicing In Mycobacteria, Daniel Wahl

Scholars Week

Intervening proteins, or inteins, are mobile genetic elements that are translated within host polypeptides and removed at the protein level by splicing. In protein splicing, a self-mediated reaction removes the intein, leaving a peptide bond in place. While protein splicing can proceed in the absence of external cofactors, several examples of conditional protein splicing (CPS) have emerged. In CPS, the rate and accuracy of splicing are highly dependent on environmental conditions. Because the activity of the intein-containing host protein is compromised prior to splicing and inteins are highly abundant in the microbial world, CPS represents an emerging form of posttranslational …

Pulmonary Health Impacts Of Golden Tobacco Flavored Cused Alto Aerosols In Vulnerable Populations Of Young Mice, Noah Black-Ocken, Blaire Holliday, Zakia Perveen, Matthew Schexnayder, Alexandra Noel

School of Public Health Delta Omega Honors Day Poster Sessions

Rationale: Vuse Alto is a popular fourth generation electronic nicotine delivery system (ENDS), also known as “e-cigarette”, that uses nicotine salt-based formulas to deliver high doses of nicotine. With over 2 million American youth using ENDS and the paucity of data regarding their health effects, serious public health concerns are being raised. Hence, the goal of this study was to investigate the pulmonary health effects, such as lung function, structure, and biochemical changes, induced by golden tobacco flavored Vuse aerosol exposures in juvenile mice. Methods: 4-week-old male BALB/c mice were exposed to either air or golden tobacco flavored Vuse Alto …

The Future Of Public Health: How The Covid-19 Pandemic Affected A Public Health Educational Pipeline, K. Thakkar, K. Bruno, M. Cuccia, F. Tsien

School of Public Health Delta Omega Honors Day Poster Sessions

Background: The Covid-19 pandemic increased awareness and interest in the field of public health, but decreased in-person internship opportunities. LSUHSC continued its funded summer internship program through the height of the pandemic. High school, undergraduate, and medical students engaged in remote, data-based research, participated in professional development workshops, and presented at the virtual symposia. The team has examined how the pandemic changed participants’ interest in public health research and pursuing public health careers.

Objectives: 1) Determine if pandemic-related public health awareness increases the number of interns conducting research with LSUHSC School of Public Health (LSUHSC-SPH) mentors. 2) Assess the participants’ …

Explaining Differences In Cardiovascular Diseae Occurrence For Cigarette Users, Kennedy Dorsey, Michael Celestin, Michael Celestin

School of Public Health Delta Omega Honors Day Poster Sessions

Background Smoking has been associated with negative cardiovascular outcomes. The Population Assessment of Tobacco and Health (PATH) Study collects data from a sample of both tobacco users and nonusers in the United States about their general health and relationship with tobacco. This data includes levels for several biomarkers that have evidence of association with tobacco use. Objectives PATH Study data was analyzed to see if there was any evidence that certain biomarkers collected were related to cardiovascular disease occurrence through cigarette and e-cigarette use and could be used as a signal for cardiovascular health risk. Methods 1,436 participants who did …

Correctional Visitation And Reentry Outcomes: A Systematic Review, Victoria Sacco, Tung Sung Tseng, Gabrielle Gonzalez

School of Public Health Delta Omega Honors Day Poster Sessions

Background: Formerly incarcerated individuals experience a high risk of financial insecurity, housing instability, and inadequate healthcare access during their reentry into the community. Subsequently, these circumstances may increase feelings of stress and psychological distress that precedes criminality and recidivism. One potential solution to mediate reentry stressors includes maintaining quality connections and relationships that provide emotional and tangible social support. While prior studies support the associations between social support and reduced stress, improved health, and reduced recidivism rates, there is less known about social support’s impact via correctional visitation. Objectives: The objective of this review is to explore the existing literature …