Digital Commons Network^™

Modeling The Binding Of Tetrodotoxin And Saxitoxin To The Nav1.7 Voltage-Gated Sodium Channel, Smrithi Mukund, Isabella Fiore, Laasya Buddharaju

Undergraduate Student Symposium

Approximately 1.5 billion people suffer from chronic pain, with 68 million people suffering in the U.S alone. Chronic pain is pain that persists longer than 12 weeks despite medication or treatment. Within the U.S. about 5.5 million cancer patients experience chronic pain. Around 20% of these pains have neuropathic origins and develop from radiation therapy. Halneuron, a new drug in development, seeks to provide pain relief to those suffering from chemotherapy-induced neuropathic pain. This drug includes Tetrodotoxin (TTX), a potent neurotoxin found in species of pufferfish. Our 3D-printed model displays the structural details of TTX as a pore blocker within …

Survivorship And Bleaching Prevalence Of Nursery-Grown Massive Stony Corals In Southeast Florida, Emma Horton

Undergraduate Student Symposium

Coral cover on Florida’s reefs has severely declined due to anthropogenic stressors. A major impact on corals is thermal bleaching, where corals expel their endosymbiotic microalgae, leaving them vulnerable to mortality. Some coral species are more resilient to thermal bleaching and thus may be prime candidates to support coral reef restoration. This study examines post-bleaching survivorship of massive stony coral species in Nova Southeastern University's offshore nursery to identify which species to include in future restoration efforts. In September 2022, 172 fragments (<3cm dia) from six massive species were secured on cement pucks and deployed to mid-water PVC trees in the nursery. Over a 14- month period, the survival and bleaching prevalence of each species were recorded during four monitoring time points. After 14 months in the nursery, total fragment survivorship was 80%, with Pseudodiploria strigosa experiencing the highest survival (100%) and Orbicella favelota experiencing the lowest (61%). Water temperature was …

Nsu Resource Guide For Gender Diverse Students, Helene R. Fisher, Meghana Jagarlamudi

Diversity Summit

No abstract provided.

Localized Collocation Meshless Method For Modeling Transdermal Pharmacokinetics In Multiphase Skin Structures, Eduardo Divo

Math Department Colloquium Series

The human skin has a complicated structure with many multi-scale, biophysical effects impacting the propagation of skin-injected substances, such as partitioning, metabolic reactions, adsorption and elimination. An extended version of Fick’s second law governing the process of the compound diffusion in various skin layer is employed in the current work by considering the conservation of mass of the substance and the metabolic reaction of the substance in viable skin. Additionally, a model assuming linear coupling between the substance concentrations that are bound and unbound with blood was developed. Using such a model, a set of coupled partial differential equations are …

Social Experience Of The Nonbinary Community, Heather M. Fox

Morehead State Theses and Dissertations

A thesis presented to the faculty of the Caudill College of Arts, Humanities, and Social Sciences at Morehead State University in partial fulfillment of the requirements for the degree of Master of Arts by Heather M. Fox on April 3, 2024.

Smokejumper Obituary: Winn, David Sheldon (Idaho City 1957), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Hira Gene Mutation In Arabidopsis Via Crispr, Kelly Chen, Claire Shippy, Tara Phelps-Durr

SACAD: Scholarly Activities

The purpose of this study is to mutate the Histone Repressor A (HIRA) gene in a mustard plant (Arabidopsis) using CRISPR technology. HIRA is a chromatin-remodeling protein that is required for proper development in both plants and animals. Creating new changes (mutations) in HIRA will help us better understand the mechanism of how HIRA regulates transcription, which is important for understanding developmental disorders in animals, as well as how improper development leads to a reduction in crop yields in plants

Impact Of Official State Messaging On Covid-19 Infection And Death Rates In Five U.S. States, Barclay Randall Murphy

Walden Dissertations and Doctoral Studies

No abstract provided.

Green Oxidation Of Aromatic Hydrazide Derivatives Using An Oxoammonium Salt, Nidheesh Phadnis, Jessica A. Molen, Shannon M. Stephens, Shayne M. Weierbach, Kyle M. Lambert, John A. Milligan

College of Life Sciences Faculty Papers

Aromatic diazenes are often prepared by oxidation of the corresponding hydrazides using stoichiometric quantities of nonrecyclable oxidants. We developed a convenient alternative protocol for the oxidation of aromatic hydrazides using Bobbitt's salt (1), a metal-free, recyclable, and commercially available oxoammonium reagent. A variety of aryl hydrazides were oxidized within 75 min at room temperature using the developed protocol. Computational insight suggests that this oxidation occurs by a polar hydride transfer mechanism.

Adverse Childhood Experiences And Adolescents’ Sense Of Self Outcomes: The Moderating Role Of Student-Teacher Relationships, Meredith Spraggon

Theses and Dissertations

This study delves into the intricate interplay between adverse childhood experiences (ACES), sense of self outcomes, and student-teacher relationships (STR). Utilizing a sample of 271 undergraduate students from a Mid-Western state, the research investigates the associations between ACES, self-esteem, social self-efficacy, and the role of STR as potential buffers against adverse outcomes. The findings revealed a high prevalence of reported ACES among participants, emphasizing the urgency to understand mitigating factors such as teacher relationships. Consistent with existing literature, ACES exhibited negative correlations with both self-esteem and social self-efficacy, underlining their detrimental impact on psychological well-being. Additionally, the study unveils a …

Social Media Does Not Elicit A Physiological Stress Response As Measured By Heart Rate And Salivary Cortisol Over 20-Minute Sessions Of Cell Phone Use, Suzanne Oppenheimer, Laura Bond, Charity Smith

Biomedical Research Institute Publications and Presentations

The pervasive use of social media has raised concerns about its potential detrimental effects on physical and mental health. Others have demonstrated a relationship between social media use and anxiety, depression, and psychosocial stress. In light of these studies, we examined physiological indicators of stress (heart rate to measure autonomic nervous system activation and cortisol to assess activity of the hypothalamic-pituitary-adrenal axis) associated with social media use and investigated possible moderating influences of sex, age, and psychological parameters. We collected physiological data from 59 subjects ranging in age from 13 to 55 across two cell phone treatments: social media use …

Culturally Responsive Research: Answering The Call, Maria K. E. Lahman

Webinars

This is the first webinar in a three-part webinar series featuring Maria K. E. Lahman, Ph.D., Professor of Qualitative Methodology at UNC. Lahman is renowned for her expertise in qualitative research and her latest book, "Ethics in Social Science Research: Becoming Culturally Responsive."

Through this three-part webinar series, Lahman challenges researchers to join the author in considering culturally responsive research. Foundations of culturally responsive qualitative research, reflexivity and ideas for enhancing the quality of qualitative research enhanced. While all webinars are stand-alone experiences, engaging with all three invites readers into deeper dialogue in an area that is contested, swiftly shifting …

Evolution Of Sequencing Technologies And Implications For Transposon Research, Renita Varghese, Jasneen Meghadri, Jennifer Pulido-Luis, Navdeep Gill

Bioinformatics

This study explores the complex field of transposable elements (TEs) and how Next Generation Sequencing (NGS) technologies are used to identify them, including their limitations. Transposons, also known as transposable elements, are dynamic DNA segments that have the ability to shift locations within a genome, impacting gene regulation, evolutionary processes, and genomic stability. TEs play vital roles in genetic research. They provide pathways for precise genetic alterations and mutagenesis, which facilitate the investigation of gene function and disease mechanisms in many organisms. Rapid DNA and RNA sequencing capabilities provided by NGS technologies have transformed genetic research. Improvements in effective DNA …

Proceedings Of The 80th Annual Meeting, Midwestern Association Of Graduate Schools

Midwestern Association of Graduate Schools

Table of Contents: 2024 MAGS Annual Meeting

St. Louis, Missouri | April 3–5, 2024 Theme: OverARCHing Issues for Graduate Education in Dynamic Times

Wednesday, April 3, 2024

Preconference: New Graduate Administrators Workshop Plenary I – Navigating Access, Cost, and Program Quality: Updates from CGS

• Strategic Initiatives for Dynamic Times
• Re-Envisioning Graduate Student Orientation in Dynamic Times
• Supporting International Graduate Students: Identifying Social, Cultural, and General Needs Beyond the Classroom to Promote a Sense of  Belonging
• Graduate Student Mental Well-Being “Y Que”: Centering Dynamic and Inclusive Practices from Within
• Bridging Graduate Connections by Developing Bachelor-to-Master’s Pathways with Liberal Arts Colleges

Thursday, …

April 3, 2024 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

April 3, 2024 (Vol. 108, No. 25), Daily Eastern News

Daily Eastern News: 2023-2024

No abstract provided.

2024-04-03 Tiktok Fights For Its Future, Bridget Lawrence

The Spectator Online

No abstract provided.

Broad-Spectrum Lignin-Based Adhesives Using Thiol–Silyl Ether Crosslinkers, Yishayah Bension, Siteng Zhang, Tristan Menninger, Ting Ge, Chuanbing Tang

Faculty Publications

Lignin is a renewable feedstock that is abundant and inexpensive but still presents challenges for its valorization. In this work, we converted functionalized lignin into broad-spectrum adhesives using thiol–silyl ether crosslinkers. The curing behavior of adhesives was investigated via rheology of their resin forms. These materials exhibit good adhesion on diverse substrates, including wood, glass, steel, aluminium, carbon fiber, and different plastics, with the most adhesion strength in the range of 1–3 MPa. These adhesives were also explored for applications, ranging from wet conditions to different mechanically responsive materials. The mechanism of adhesion was further examined to understand the bonding …

Where Have All The Flowers Gone? A Call For Federal Leadership In Deer Management In The United States, Bernd Blossey, Darragh Hare, Donald M. Waller

Aspen Bibliography

Forests in the United States continue to lose biodiversity and many fail to regenerate due to high deer (family Cervidae) abundance. Declines in biodiversity and overall ecosystem health due to high deer populations increases prevalence of wildlife and human diseases associated with increasing tick abundances and decreases forest resilience and the ability to deliver benefits provided by healthy ecosystems. In the eastern and midwestern United States, white-tailed deer (Odocoileus virginianus) are the main stressor, while in the western U.S. elk (Cervus elaphus) and black-tailed and mule deer (Odocoileus hemionus) can become equally problematic. Federal …

Controlling Light-Matter Interactions In The Linear And Nonlinear Optical Regimes, Bryson Joseph Krause

Electronic Theses and Dissertations Archive

The progression of materials science has led us down a path of rich discovery in the realm of nanophotonics. Recent strides in metamaterials and plasmonics research have allowed for an unprecedented control of light-matter interactions beyond the diffraction limit of visible light. Currently, there is a great push to improve the ability and flexibility of metamaterials and nanophotonic structures to manipulate and amplify electromagnetic waves. Researchers are seeking to find efficient, scalable and cost-effective methods to produce these materials with a broad range of tunability. In these efforts, the scope of optics research has naturally begun to shift from the …

The Role Of Dna Methylation And Parental History On Wheezing Trajectories In Children, Donald Eugene Warden

Electronic Theses and Dissertations Archive

Asthma and wheezing present public health changes that manifest during early childhood. This dissertation utilizes longitudinal data within the Isle of Wight Birth Cohort (IOWBC) third generation to explore the development of early childhood wheezing phenotypes, their implications for asthma development, including environmental and epigenetic factors. Children in the F2-generation (n=611) of the IOWBC were followed-up at 3, 6, 12, 24, 36, and 72 months, and the incidence of wheeze subtype (general, infectious, and non-infectious) were used in group-based trajectory models to identify phenotypes of early childhood wheezing. These trajectories were examined as predictors of asthma diagnosis, lung function, and …

Navigating Murky Waters: State-Level Strategies For Wetland Preservation And Tile Drainage Regulation After Sackett V. Epa, Caleb M. Swanson

Honors Thesis

Wetlands are some of the world’s most valuable ecosystems, serving as provisioners of species habitat, carbon sequestration, flood mitigation, water quality purification, and other ecosystem services. Human development has resulted in substantial wetland loss the world over. In the 1970s, the United States Congress passed the Clean Water Act, giving the EPA broad authority over wetland protection. However, in the summer of 2023, the United States Supreme Court decided Sackett v. EPA, limiting the EPA’s jurisdiction over wetlands to those indistinguishably connected to generally recognized “Waters of the United States” and removing federal protection for millions of acres of wetlands, …

The Impact Of Mutations In The Arabidopsis Apetela (Ap3) Gene, Hazel R. Frans, Tara Phelps-Durr

SACAD: Scholarly Activities

The purpose of this research is to understand the molecular functioning of the Arabidopsis thaliana Apetela (Ap3) gene. We created mutations in two sites of the gene, AP3-3 and AP3-5. These are predicted to change AP3 protein structure, which may result in a mutated flower. Analyzing the effects of new mutations allows an understanding of protein formation both in plants and humans.

Career Technical And Agricultural Education Teachers In Rural Schools: Perceptions Of Leadership Abilities, Professional Support, And Overall Job Satisfaction Following Participation In A Teacher Leadership Professional Learning Community, Tasia Ellis

Dissertations

Career Technical Education (CTE), including Career Technical Agricultural Education (CTAE) in Georgia, are experiencing difficulty retaining quality teachers. This problem is exacerbated in rural communities, which have a smaller workforce pool and fewer nearby colleges to certify CTE/CTAE teachers (Morton, 2021). A potential solution to offset teacher retention concerns is teacher leadership. When teachers are given opportunities to take on leadership roles, they are likely to feel more valued and experience increased self-efficacy and perceptions of ability (Katzenmeyer & Moller, 2009). The purpose of this phenomenographic study was to examine whether a teacher leadership Professional Learning Community (PLC) enhanced teachers' …

Antiobesity And Antidyslipidemic Properties Of Clitoria Ternatea Petals Aqueous Extract Against Rats Induced By High-Fat Diet, I Gede Aswin Parisya Sasmana, Desak Made Wihandani, I Gede Krisna Arim Sadeva, Wilson Halim, Putu Putri Agustini, Lalita Samala, I Gusti Ngurah Agung Surya Pratama, Lidiya Nuraliza Rachmawati, Aizar Vesa Prasetyo, Ni Komang Ayu Amanda Setiari Jaya

Turkish Journal of Medical Sciences

Background/aim: Obesity is a chronic metabolic disease involving dysregulation of fat metabolism that affects 13% of the world’s population. Obesity has been linked to dyslipidemia with a lot of complication, including stroke, chronic kidney disease, fatty liver disease, and so on. One of the natural resources that have several potential effects including anticholesterol, antiobesity, and antidyslipidemia is the butterfly pea (Clitoria ternatea/CT). CT’s petal has been found to contain high levels of anthocyanins and tannins that can inhibit the biosynthesis of cholesterol and lipid. This study aims to investigate the antiobesity and antidyslipidemic effects of Clitoria ternatea extract (CTE).Materials and …

The Effect Of Human Recombinant Epidermal Growth Factor On Neovascularization And Pedicle Division Time In A Rat Interpolation Flap Model, Aziz Parspanci, Yavuz Keçeci̇, Peyker Temi̇z

Turkish Journal of Medical Sciences

Background/aim: In practice, waiting 2–3 weeks for interpolation flaps pedicle division result in certain morbidities and discomfort for patient. The division time of flap pedicle depends on neovascularization from the recipient bed and includes wound healing stages. We aimed to investigate the effect of recombinant human epidermal growth factor (rhEGF) on the flap viability during early pedicle division.Materials and methods: Thirty-six rats were allocated to two main groups as control and study. A cranial based flap measuring 5 × 5 cm was elevated from the back, including all layers of the skin. While the cranial half of the defect was …

Classification Of Lakebed Geologic Substrate In Autonomously Collected Benthic Imagery Using Machine Learning, Joseph K. Geisz, Phillipe A. Wernette, Peter C. Esselman

Michigan Tech Publications

Mapping benthic habitats with bathymetric, acoustic, and spectral data requires georeferenced ground-truth information about habitat types and characteristics. New technologies like autonomous underwater vehicles (AUVs) collect tens of thousands of images per mission making image-based ground truthing particularly attractive. Two types of machine learning (ML) models, random forest (RF) and deep neural network (DNN), were tested to determine whether ML models could serve as an accurate substitute for manual classification of AUV images for substrate type interpretation. RF models were trained to predict substrate class as a function of texture, edge, and intensity metrics (i.e., features) calculated for each image. …

The Challenges And Opportunities Of Beneficially Reusing Produced Water, Amy Hardberger

Duke Environmental Law & Policy Forum

No abstract provided.

Speech And Language Errors In An 8-Year-Old Spanish-English Bilingual Speaker: A Case Study, Alaniss Heredia

LSU Master's Theses

Despite the growing population of Spanish-English bilingual speakers with developmental language disorders and speech sound disorders (SSD) in the United States, there is limited research on assessment for this population. Research suggests that the linguistic environment in which the Spanish-English bilingual speakers are brought up should be considered when assessing and treating this population since the Spanish-English bilingual population is diverse. One result of such environments is differences in degrees of language exposure. For example, a child can be exposed to two languages but have more exposure in one than the other. This might lead to better proficiency in one …

Investigating Drivers Of High Wetland Loss Rates In Brackish Marshes Of The Mississippi River Delta, Natalie M. Matherne

LSU Master's Theses

Coastal wetlands provide numerous ecological services, but high rates of wetland loss have been seen, especially within the Mississippi River Delta. The erodibility of the marsh, which depends on its strength, can be affected by waterlogging-impacted factors. This study focused on investigating factors influencing soil shear strength in brackish to intermediate salinity marshes along the northern Gulf of Mexico coast using a comparative field study and a controlled greenhouse experiment to test the hypothesis that soil waterlogging reduces soil strength. I predict species-specific responses such that marshes dominated by the Sporobolus pumilus (formerly, Spartina patens), which is less flood …