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Historical And Morphological Review Of The Subgenus Indonthophagus Kabakov, 2006 Of Onthophagus Latreille, 1802 (Coleoptera: Scarabaeidae: Scarabaeinae: Onthophagini), Stefano Ziani

Insecta Mundi

The subgenus Indonthophagus Kabakov, 2006 of Onthophagus Latreille, 1802 (Coleoptera: Scarabaeidae: Scarabaeinae: Onthophagini) is reviewed. A morphological definition of it is provided. A diagnosis, based both on external and internal characters, of the seven species deemed to belong to the group according to literature, is supplied. As a result, Onthophagus spinifex (Fabricius, 1781), previously placed with some uncertainty in the subgenus, is definitively excluded. A key to Indonthophagus species is also provided, as well as images of male, aedeagus and endophallus for each species. New country records of Onthophagus turbatus Walker, 1858 for Pakistan, Nepal, and Bhutan are given.

ZooBank …

Diagnosis Of Spilococcus Pacificus (Borchsenius, 1949) And An Updated List Of Scale Insects (Hemiptera: Coccomorpha) On Pears (Pyrus L.: Rosaceae) In South Korea, Jungyoun Ji, Soo-Jung Suh

Insecta Mundi

Pears, Pyrus pyrifolia (Burm.f.) Nak. (Rosaceae) are one of the most widely grown fruit trees in South Korea. Approximately 11% of the total pear production in 2022 was exported to countries such as the United States and Vietnam. Exported pears must be free of pest species that are considered of quarantine importance by the importing countries. Herein, a list of scale insects (Hemiptera: Coccomorpha) associated with pear trees is updated. Additionally, Spilococcus pacificus (Borchsenius) is added to the list of mealybugs affecting pears in South Korea and is briefly diagnosed based on non-type specimens and illustrated using photographs. Information on …

Review Of Pharaxonotha Reitter (Coleoptera: Erotylidae: Pharaxonothinae) Inhabiting Cones Of The Cycad Zamia L. (Cycadales) In Panama, With Descriptions Of Five New Species, William Tang, Paul E. Skelley, Alberto S. Taylor R., Shayla Salzman

Insecta Mundi

The beetle genus Pharaxonotha Reitter (Coleoptera: Erotylidae: Pharaxonothinae) is found in the cones of cycad genera in the New World, including species of Ceratozamia Brongn., Dioon Lindl., Microcycas (Miq.) A.DC, and Zamia L. Its presence and diversity are analyzed for the 17 species of Zamia known to occur in Panama. Nine species are recognized, and five new species are described: Pharaxonotha clarkorum Pakaluk, P. confusa Pakaluk, P. fortunensis Tang, Skelley and Taylor new species, P. holzmani Tang, Skelley and Taylor new species, P. kirschii Reitter, P. manicatae Tang, Skelley and Taylor new species …

Acalyptomerus Asiaticus Crowson (Coleoptera: Clambidae: Acalyptomerinae) New To The Faunae Of The United States, Dominican Republic And Vietnam, Michael A. Ivie, Susan E. Halbert

Insecta Mundi

Acalyptomerus asiaticus Crowson (Coleoptera: Clambidae: Acalyptomerinae) is recorded for the first time from the United States (Florida), Dominican Republic, and Vietnam.

ZooBank registration. urn:lsid:zoobank.org:pub:F05EE9D0-7305-4C6B-BE7F-8D9E86C66AA7

Harnessing Exosomes As A Platform For Drug Delivery In Breast Cancer: A Systematic Review For In Vivo And In Vitro Studies, Abdulwahab Teflischi Gharavi, Saeed Irian, Azadeh Niknejad, Keykavous Parang, Mona Salimi

Pharmacy Faculty Articles and Research

Breast cancer remains a significant global health concern, emphasizing the critical need for effective treatment strategies, especially targeted therapies. This systematic review summarizes the findings from in vitro and in vivo studies regarding the therapeutic potential of exosomes as drug delivery platforms in the field of breast cancer treatment. A comprehensive search was conducted across bibliographic datasets, including Web of Science, PubMed, and Scopus, using relevant queries from several related published articles and the Medical Subject Headings Database. Then, all morphological, biomechanical, histopathological, and cellular-molecular outcomes were systematically collected. A total of 30 studies were identified based on the Preferred …

Design And Test Of Wpum Topography Monitor For Iqos, Rawah Azeez

Theses

With the emergence of diverse tobacco product forms, such as electronic cigarettes and heat-not-burn, the global user base has surged to an estimated 1.3 billion. In the United States, 28.3 million adults and 3.08 million middle and high school adolescents engage in tobacco product use. However, our understanding of the usage behaviors of these various products is lacking. Puff topography, which measures the inhalation patterns of tobacco products, provides a wealth of information, including puff flow rate, duration, volume, and more. This information is crucial in understanding the health effects of tobacco products and the influence of usage behavior on …

Measuring Impulse-Dsi And Its Derivatives Via The Isometric Belt Squat: Assessing Relationships With Sprint Ability Among Division I Team Sport Athletes, Matthew Ward

Doctorate in Kinesiology

Measuring Impulse-DSI and its Derivatives Via the Isometric Belt Squat: Assessing Relationships with Sprint Ability Among Division I Team Sport Athletes

The Effects Of Global Temperature Change On Radon Exposure In Permafrost Areas, Melaan Bender

LSU Master's Theses

Global temperature increase leads to thawing of permafrost that protects local populations from radiation exposure by blocking radon-222 migrating into dwellings. This study aims at assessing the effects of permafrost thawing on the concentrations of radon in indoor air. An approach is developed to predict the evolution of the ²²²Rn concentrations by various processes including radon exhalation from thawed soil. It is found that as frozen soil thaws, more radon can enter dwellings, increasing the concentration of ²²²Rn in indoor air and elevating radiation-induced health risks. This study provides useful insight that will enhance understanding of potential climate …

Spatial Mapping Of The Benthic Community And How It Is Used To Research Effects Of Dredging In Louisiana's Lake Borgne., Meghan Johnson

LSU Master's Theses

Benthic communities are vitally important for healthy aquatic ecosystems across Louisiana’s coast. Specifically in Lake Borgne, ecologically important species of fish like the Gulf Sturgeon (Acipenser oxyrinchus desotoi) rely on benthic macrofauna as their main food source. The purpose of this study was to determine the spatial landscape of biodiversity and abundance of the benthic macrofauna community in Lake Borgne. Environmental conditions played a key role in community structure during the study period (fall 2021 through summer 2023) with a major drought occurring in 2023. In 2023, the decline in the abundance of most benthic invertebrates and in …

Examination Of The Effects Of Ultraviolet Radiation On The Toxicity Of An Array Of Pesticides, Polyaromatic Hydrocarbons, And Pharmaceuticals Via In-Vitro Bioassays, Jessica R. Stephens

LSU Master's Theses

Chemicals are often released via anthropogenic means both intentionally and unintentionally into aquatic environments. The chemical fate of these compounds can vary greatly depending on numerous factors that can include but are not limited to salinity, pH, dissolved oxygen, and exposure to ultraviolet radiation. The goal of this study was to investigate the effect of UV radiation on the level of toxicity of different chemicals over time. Chemicals were selected based on previous studies of the toxicity of both parent and metabolites formed as a result of photolysis. Anthracene, phenanthrene, anthraquinone, dicloran, chlorothalonil, hydroxy chlorothalonil, benzobicyclon hydrolysate, and sertraline were …

Enhancement Of Soybean Growth And Disease Resistance Through Seed-Priming Strategy, Francisco Javier Valle

LSU Master's Theses

Disease pressure and other environmental stresses, especially increasing temperature and drought incidence, accompanied with global climatic change have presented hard challenges to Louisiana soybean producers. The objective of this study was to explore the efficacy of seed priming techniques as new alternatives to improve soybean crop protection to reduce the amount of yield losses caused by biotic and abiotic stresses. In this study, five chemicals were used as priming agents at different concentrations (0.1 mM, 1 mM, and 10 mM) to evaluate their effectiveness in enhancing disease tolerance and yield in soybeans. A seed priming procedure was developed by partially …

A Novel Goat Model To Characterize Male Fertility Following Paternal Cannabidiol Exposure, Ashlyn N. Brewer

LSU Master's Theses

Despite the increasing use of cannabidiol, both for medical and social purposes, the effect of cannabidiol on male fertility is poorly understood. Previous studies have been carried out in rodent models, but a large animal model does not exist at this time. This experiment proposes chronic cannabidiol (CBD) exposure using a goat model to understand the impact CBD has on male reproductive performance. The purpose of this project is to determine if daily exposure to CBD in male goats would impact reproductive parameters such as sperm quality and testosterone levels.

Two studies were conducted to determine the effects of CBD …

Structural, Spectroscopic, And Computational Insights From Canavanine-Bound And Two Catalytically Compromised Variants Of The Ethylene-Forming Enzyme, Shramana Chatterjee, Matthias Fellner, Joel A. Rankin, Midhun George Thomas, Simahudeen Bathir Jaber Sathik Rifayee, Christo Christov, Jian Hu, Robert P. Hausinger

Michigan Tech Publications

The ethylene-forming enzyme (EFE) is an Fe(II), 2-oxoglutarate (2OG), and l-arginine (l-Arg)-dependent oxygenase that either forms ethylene and three CO2/bicarbonate from 2OG or couples the decarboxylation of 2OG to C5 hydroxylation of l-Arg. l-Arg binds with C5 toward the metal center, causing 2OG to change from monodentate to chelate metal interaction and OD1 to OD2 switch of D191 metal coordination. We applied anaerobic UV-visible spectroscopy, X-ray crystallography, and computational approaches to three EFE systems with high-resolution structures. The ineffective l-Arg analogue l-canavanine binds to the EFE with O5 pointing away from the metal center while promoting chelate formation by 2OG …

Positioning Disability In Wilderness Space, Rebecca Hobart

Geography ETDs

This thesis examines the social construction of the disabled body in recreational wilderness space. A political ecology framework guides the research questions: What are the actual or perceived barriers to participation for differently abled hikers in wilderness recreational spaces, and how do these challenges manifest in long-distance hiking spaces? In situating Foucault’s theories of the body as shaped by power relations, this thesis asserts wilderness spaces to be privileged based on power conceptualized in normative notions of ability. 44 participants who self-identified as wilderness recreationalists with a disability and/or chronic health illness completed this study’s mixed-method questionnaire. Themes around practices, …

Human Brain Glycoform Coregulation Network And Glycan Modification Alterations In Alzheimer's Disease, Qi Zhang, Cheng Ma, Lih-Shen Chin, Sheng Pan, Lian Li

Faculty, Staff and Student Publications

Despite the importance of protein glycosylation to brain health, current knowledge of glycosylated proteoforms or glycoforms in human brain and their alterations in Alzheimer's disease (AD) is limited. Here, we report a proteome-wide glycoform profiling study of human AD and control brains using intact glycopeptide-based quantitative glycoproteomics coupled with systems biology. Our study identified more than 10,000 human brain N-glycoforms from nearly 1200 glycoproteins and uncovered disease signatures of altered glycoforms and glycan modifications, including reduced sialylation and N-glycan branching and elongation as well as elevated mannosylation and N-glycan truncation in AD. Network analyses revealed a higher-order organization of brain …

A Power Elite Alliance And Local Environmental Policy: Elon Musk In Cameron County, Michelle Keck, Guadalupe Correa-Cabrera

Political Science Faculty Publications

The present work analyzes several aspects related to the environmental impacts that Elon Musk’s company Space Exploration Technologies (SpaceX) has had on Cameron County, Texas. Utilizing prior studies, we will focus on how the power elite impact policy at the federal, state, and local levels, specifically regarding SpaceX’s arrival to Cameron County as well as environmental policy concerning the activities at the SpaceX Starbase facility, located on Boca Chica Beach, Texas. The present analysis uses data from semi-structured interviews with key stakeholders including government officials, developers, environmentalists, and other activists in order to understand the connections between the global and …

Teaching Creatives To Be A.I. Provocateurs: Establishing A Digital Humanist Approach For Generative A.I. In The Classroom, Joshua A. Fisher

Tradition Innovations in Arts, Design, and Media Higher Education

This case study examines the implementation of OpenAI's Generative AI (GenAI) in a graduate interactive storytelling course at Ball State University in Spring '23. Adopting a Posthumanist perspective, the course treated GenAI as a synthetic collaborator to bridge technical disparities among the students, enhancing their characters, dialogue, and visual production. Students also used the tool to help understand complex technical documentation. However, while the approach led to overall success, the case study proposes a shift towards Digital Humanism for a more balanced, ethical integration of GenAI in the classroom. This perspective prioritizes human creative agency over computational creativity, encouraging students …

Flaxman, Judy, Laura Oldfather

Bronx Jewish History Project

Summarizer: Sophia Maier

Judy Flaxman’s family came to the Lower East Side from Eastern Europe in the early 1900s. As they grew more affluent, they moved to the Bronx, where Flaxman was born in 1948. She lived on Walton Avenue near Tremont Avenue, which she describes as very Jewish with some Catholics. She attended PS 28, Wade Junior High School, and Bronx Science. She played many outdoor games with friends from her community and did after school activities at the YM/WHA, through which she attended a day camp during the summers.

Flaxman’s mother was a secretary and her father, after …

Deepdof-Se: Affordable Deep-Learning Microscopy Platform For Slide-Free Histology, Lingbo Jin, Yubo Tang, Jackson B Coole, Melody T Tan, Xuan Zhao, Hawraa Badaoui, Jacob T Robinson, Michelle D Williams, Nadarajah Vigneswaran, Ann M Gillenwater, Rebecca R Richards-Kortum, Ashok Veeraraghavan

Faculty, Staff and Student Publications

Histopathology plays a critical role in the diagnosis and surgical management of cancer. However, access to histopathology services, especially frozen section pathology during surgery, is limited in resource-constrained settings because preparing slides from resected tissue is time-consuming, labor-intensive, and requires expensive infrastructure. Here, we report a deep-learning-enabled microscope, named DeepDOF-SE, to rapidly scan intact tissue at cellular resolution without the need for physical sectioning. Three key features jointly make DeepDOF-SE practical. First, tissue specimens are stained directly with inexpensive vital fluorescent dyes and optically sectioned with ultra-violet excitation that localizes fluorescent emission to a thin surface layer. Second, a deep-learning …

Unsupervised Deep Representation Learning Enables Phenotype Discovery For Genetic Association Studies Of Brain Imaging, Khush Patel, Ziqian Xie, Hao Yuan, Sheikh Muhammad Saiful Islam, Yaochen Xie, Wei He, Wanheng Zhang, Assaf Gottlieb, Han Chen, Luca Giancardo, Alexander Knaack, Evan Fletcher, Myriam Fornage, Shuiwang Ji, Degui Zhi

Faculty, Staff and Student Publications

Understanding the genetic architecture of brain structure is challenging, partly due to difficulties in designing robust, non-biased descriptors of brain morphology. Until recently, brain measures for genome-wide association studies (GWAS) consisted of traditionally expert-defined or software-derived image-derived phenotypes (IDPs) that are often based on theoretical preconceptions or computed from limited amounts of data. Here, we present an approach to derive brain imaging phenotypes using unsupervised deep representation learning. We train a 3-D convolutional autoencoder model with reconstruction loss on 6130 UK Biobank (UKBB) participants' T1 or T2-FLAIR (T2) brain MRIs to create a 128-dimensional representation known as Unsupervised Deep learning …

Effective Project Management Strategies For Identifying And Addressing Projects' Complexities And Improving Projects' Success Rates, Daryl L. Gilbert Ii

Walden Dissertations and Doctoral Studies

No abstract provided.

Predictors Of Prep Uptake By Black Gay And Bisexual Men In Ohio, Ade Elisha

Walden Dissertations and Doctoral Studies

No abstract provided.

Students To Present Research From Variety Of Disciplines At John Wesley Powell Conference On April 13, Julia Perez

News and Events (Discontinued Series)

No abstract provided.

Discovery Of A Small-Molecule Inhibitor That Traps Polθ On Dna And Synergizes With Parp Inhibitors, William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa L Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John Krais, Yifan Wang, Umeshkumar Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang Chen, Richard Pomerantz

Department of Biochemistry and Molecular Biology Faculty Papers

The DNA damage response (DDR) protein DNA Polymerase θ (Polθ) is synthetic lethal with homologous recombination (HR) factors and is therefore a promising drug target in BRCA1/2 mutant cancers. We discover an allosteric Polθ inhibitor (Polθi) class with 4-6 nM IC₅₀ that selectively kills HR-deficient cells and acts synergistically with PARP inhibitors (PARPi) in multiple genetic backgrounds. X-ray crystallography and biochemistry reveal that Polθi selectively inhibits Polθ polymerase (Polθ-pol) in the closed conformation on B-form DNA/DNA via an induced fit mechanism. In contrast, Polθi fails to inhibit Polθ-pol catalytic activity on A-form DNA/RNA in which the enzyme binds in …

Deparylation Is Critical For S Phase Progression And Cell Survival, Litong Nie, Chao Wang, Min Huang, Xiaoguang Liu, Xu Feng, Mengfan Tang, Siting Li, Qinglei Hang, Hongqi Teng, Xi Shen, Li Ma, Boyi Gan, Junjie Chen

Faculty, Staff and Student Publications

Poly(ADP-ribose)ylation or PARylation by PAR polymerase 1 (PARP1) and dePARylation by poly(ADP-ribose) glycohydrolase (PARG) are equally important for the dynamic regulation of DNA damage response. PARG, the most active dePARylation enzyme, is recruited to sites of DNA damage via pADPr-dependent and PCNA-dependent mechanisms. Targeting dePARylation is considered an alternative strategy to overcome PARP inhibitor resistance. However, precisely how dePARylation functions in normal unperturbed cells remains elusive. To address this challenge, we conducted multiple CRISPR screens and revealed that dePARylation of S phase pADPr by PARG is essential for cell viability. Loss of dePARylation activity initially induced S-phase-specific pADPr signaling, which …

Impact Of Living Donor Liver Transplantation On The Improvement Of Hepatocellular Carcinoma Treatment, Yucel Yankol, Oswaldo Aguirre, Luis A Fernandez

Faculty, Staff and Student Publications

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths, with increasing incidence. There are different treatment options, but only 30%-40% of HCC cases are diagnosed at an early stage for curative treatment. With the implementation of Milan Criteria for liver transplantation (LT) in HCC cases and its use for organ allocation with successful outcomes, LT has become an optimal treatment. Seeking new criteria for LT and developing updated algorithms for HCC treatment has become a hot topic nowadays. With the experience in living donor liver transplantation (LDLT), especially in Asian countries, LDLT was established and adopted with …

The Saga Of E Faecium, Rishika Prasad, Robert R Jenq

Faculty, Staff and Student Publications

An enzyme that remodels the cell wall of Enterococcus faecium helps these gut bacteria to divide and generate peptide fragments that enhance the immune response against cancer.

The Diamond, April 5, 2024, Dordt University

Dordt Diamond

• Front Page: Women's Basketball Wins First Ever National Championship; Local Agencies Respond to Sioux Center's Housing Crisis; Simulations Stimulate Learning
• News: Dordt Students Win State CFA Research Challenge; Dordt Announces Class Schedule Change; Paying for Perusall; IdeaFest Offers Unique Opportunity to Share Knowledge; Indoor Fair Connects Campus and Community; FLAME Club Travels to Wisconsin; Lambertus Verburg Prize Awarded to Two Sophomores
• Feature: From Chaos to Hope: Haitian Refugee Finds Safety in Sioux Center; Self-Defense Classes Empower and Equip Students; From Dordt Student to Admissions Counselor; The Toidmaster Tradition Lives On
• Arts & Entertainment: A Musical …

Race And Racism Through The Lens Of Black Men: Exploring The Talk And Lessons Black Fathers Teach Their Children About Race And Racism In America., Conial C. Caldwell Jr

LSU Doctoral Dissertations

The history of racism and racial violence is embedded in the fabric of America and has driven Black people to develop strategies to navigate society that racism has produced. “The Talk” is a racial socialization practice and cultural phenomenon that has existed within Black families for centuries and remains a necessity due to the ongoing acts of racism and violence of Black Americans. Prior research has found that parents rear their children based on their own lived experiences, which many Black Americans have experienced or have been exposed to racism and racial violence. Yet, there are few empirical studies that …

Investigating The Role Of Fluid Shear Stress During Metastasis On Enhanced Breast Cancer Extravasation, Alejandra M. Ham

LSU Master's Theses

In 2022, ~288,000 American women were diagnosed with metastatic breast cancer which was the leading cause of patient mortality with ~43,000 American women succumbing to the disease. Women can be diagnosed with four different molecular subtypes of breast cancer: luminal A, luminal B, human epithelial growth receptor type 2 enriched (HER2+), and triple-negative breast cancer (TNBC). TNBC accounts for ~12% of all breast cancers, yet it has the worst outcomes. TNBC is highly invasive, with ~46% of TNBC patients developing metastatic disease. A further understanding of metastatic TNBC is needed to provide a greater understanding of how to treat this …