Digital Commons Network^™

Substance Users’ Perspectives On Harm Reduction Strategies In Housing First Programs, Tammy Montague

Walden Dissertations and Doctoral Studies

The social problem of housing instability for individuals with substance use issues is well known. Researchers have found that 50% of homeless individuals have a substance use disorder with a reduction in life expectancy compared to the general population. With 1% of the U.S. population experiencing homelessness, Housing First with its core component of harm reduction has been embraced by U.S. policymakers as a strategic solution towards ending homelessness through low-barrier permanent supportive housing. This generic qualitative study explored the perspectives of individuals with substance use experience about harm reduction strategies accessed that helped them to overcome system related barriers. …

Afamitresgene Autoleucel For Advanced Synovial Sarcoma And Myxoid Round Cell Liposarcoma (Spearhead-1): An International, Open-Label, Phase 2 Trial, Sandra P D'Angelo, Dejka M Araujo, Albiruni R Abdul Razak, Mark Agulnik, Steven Attia, Jean-Yves Blay, Irene Carrasco Garcia, John A Charlson, Edwin Choy, George D Demetri, Mihaela Druta, Edouard Forcade, Kristen N Ganjoo, John Glod, Vicki L Keedy, Axel Le Cesne, David A Liebner, Victor Moreno, Seth M Pollack, Scott M Schuetze, Gary K Schwartz, Sandra J Strauss, William D Tap, Fiona Thistlethwaite, Claudia Maria Valverde Morales, Michael J Wagner, Breelyn A Wilky, Cheryl Mcalpine, Laura Hudson, Jean-Marc Navenot, Tianjiao Wang, Jane Bai, Stavros Rafail, Ruoxi Wang, Amy Sun, Lilliam Fernandes, Erin Van Winkle, Erica Elefant, Colin Lunt, Elliot Norry, Dennis Williams, Swethajit Biswas, Brian A Van Tine

Faculty, Staff and Student Publications

Background: Afamitresgene autoleucel (afami-cel) showed acceptable safety and promising efficacy in a phase 1 trial (NCT03132922). The aim of this study was to further evaluate the efficacy of afami-cel for the treatment of patients with HLA-A*02 and MAGE-A4-expressing advanced synovial sarcoma or myxoid round cell liposarcoma.

Methods: SPEARHEAD-1 was an open-label, non-randomised, phase 2 trial done across 23 sites in Canada, the USA, and Europe. The trial included three cohorts, of which the main investigational cohort (cohort 1) is reported here. Cohort 1 included patients with HLA-A*02, aged 16-75 years, with metastatic or unresectable synovial sarcoma or myxoid …

Comparative Genomics Of Selected Lactobacillus Helveticus Strains, Cain Petty

Undergraduate Research Conference

My research is to compare two strains (D76 and H10) of Lactobacillus helveticus and a shared gene between them. I would want to experiment with overexpression to test for any difference in the regulatory function of genes associated with CggR - the central glycolytic genes regulator. The poster I am presenting would outline this and provide a clearer understanding of genes and potential overexpression.

Unraveling The Genomic Landscape Of Staphylococcus Aureus: A Microbial Genomics Perspective, Kimi Norway

Undergraduate Research Conference

Staphylococcus aureus is a common pathogen implicated in various skin conditions, including boils (furuncles) and atopic dermatitis (eczema). Understanding the virulence factors contributing to these skin infections is essential for developing targeted therapeutic interventions. This research aims to compare the virulence factors, including toxins, adhesins, and immune evasion proteins, of two Staphylococcus aureus strains associated with boils and atopic dermatitis: Strain A (ST398) and Strain B (NCTC 8325).

Doxorubicin-Induced Nuclear Localization Of Scube3 Essential For Cell Survival In Tnbc, Ayooluwa Ilesanmi

Undergraduate Research Conference

Mediation of Doxorubicin-Induced SCUBE3 Nuclear Localization by A Functional NLS Involved in Pro-Tumorigenic Actions in Breast Cancer.

Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is a glycosylated secreted and cell membrane-associated protein considered a signature gene in cancers and known to mediate its actions in the cytoplasm where its localizes prior to its secretion. However, our study observed that SCUBE3 protein localized to the nucleus following doxorubicin (DOX) treatment. In this study, we investigated SCUBE3 nuclear localization in triple-negative breast cancer, intending to dissect the mechanism of its nuclear trafficking induced by DOX treatment. Bioinformatic analysis of the SCUBE3 protein sequence …

Upregulation Of The Predominant Cystic Fibrosis Causing Mutation Df508-Cftr By Triazole Compounds In Epithelial Cells, Maggie Taylor

Undergraduate Research Conference

Cystic fibrosis is a common genetic disease that is caused by a mutation in the plasma membrane protein CFTR, which stands for Cystic Fibrosis Transmembrane-conductance Regulator. When this membrane protein is mutated, it impairs its chloride ion channel function, blocking the movement of chloride ions that travel in and out of the cell. Previous studies have demonstrated that the most prevalent CFTR mutation, ∆F508-CFTR, can be partially reversed using small molecules (Heda and Marino, BBRC, 271:659-664, 2000). In this study, I have investigated the effects of several triazole compounds known to bind and transport chloride ions in cultured cells, on …

Gene Expression Analysis Of Atypical Fibroxanthoma Patients Reveals New Insights Into The Tumor Microenvironment, Nia Gyongyosi, Aya Al-Nazal, Shehbeel Arif

Tower Health Research Day

No abstract provided.

Assessment Of Wearable Vert Technology In Collegiate Volleyball Athletes, Nicole Stanchfield, Pradeep Vanguri, Valerie Starratt

InterLACE Research Showcase

No abstract provided.

Adaptation Production Plan For Khaled Hosseini's A Thousand Splendid Suns, Aman Bhayani

FUSION

The Adaptation Production Plan is a proposal that explores the idea of taking an existing piece of work and adapting it into a live version of a TV show or film. Particularly, for my adaptation, I chose the novel, A Thousand Splendid Suns by Khaled Hosseini. This paper provides a summary of novel's key events and the purpose behind selecting the novel. Then, focusing on the adaptation, just like any other TV show, the proposal presents the selection of actors, locations, specific plot points and music in order to film the show and the reasoning behind them.

The project was …

Harnessing Ketosis For Heart Health: Insights Into Long Noncoding Rna-Mediated Mitochondrial Protection, Narasimman Gurusamy, Talan Tran, Natalia Noto, Zachary Lawrence, Shalet James, Iliana Uribe, Ariana Hernandez, Robert Speth, Lisa Robison

InterLACE Research Showcase

No abstract provided.

Bec-1 Survey Of Parasites In Ictalurus Punctatus (Channel Catfish) Of The Savannah River Basin At Little River In Mccormick, South Carolina, Savannah Cade, Jason Lee

SC Upstate Research Symposium

Ictalurus punctatus, more commonly known as the Channel Catfish, is common throughout the Savannah River Basin. Fifteen specimens were captured by hook and line from the Little River in McCormick County, South Carolina. The gills and viscera were examined for metazoan parasites and prevalence and mean intensity were computed. The monogenean Ligictaluridus pricei and the copepod Ergasilus arthrosis were recovered from the gills. Two digenetic trematodes (Megalonia ictaluri and Alloglossidium corti), one tapeworm (Corallobothrium fimbriatum), two nematodes (Camallanus oxycephalus and Spinitectus carolini) and one acanthocephalan (Neoechinorhynchus cylindratus) were recovered from the …

Cpm-8 Europa Unveiled: A Multi-Wavelength Analysis, Trinity A. Ward, Michelle Deady

SC Upstate Research Symposium

This study is an analysis of the compositional structure of Jupiter’s icy moon, Europa, by utilizing multi-wavelength spectroscopy. The objective of this study is to enhance our understanding of Europa’s compositional and potential biological characteristics.

Spectral data was obtained from various space missions and instruments. We are looking at imaging and spectroscopy-focused instruments RALPH, LORRI, LEISA, ALICE, and MVIC which were all part of the New Horizons spacecraft that launched in 2006. The data collected was from the Jupiter fly-by in February-March 2007.

This project sets the tone for the year with the upcoming Europa Clipper mission by NASA, set …

Hgs-3 The Influence Of A Tandem Cycling Program In The Community On Physical And Functional Health, Therapeutic Bonds, And Quality Of Life For Individuals And Care Partners Coping With Parkinson’S Disease, Leila Djerdjour, Jennifer L. Trilk

SC Upstate Research Symposium

Purpose Statement: Several studies have shown that aerobic exercise can have a positive impact on alleviating symptoms experienced by individuals with Parkinson's disease (PD). Despite this evidence, the potential benefits of exercise for both PD patients and their care partners (PD dyad) remain unexplored. This research project investigates the effectiveness, therapeutic collaborations, and physical outcomes of a virtual reality (VR) tandem cycling program specifically designed for PD dyads.

Methods: Following approval from the Prisma Health Institutional Review Board, individuals with PD were identified and screened by clinical neurologists. The pre-testing measures for PD dyads (N=9) included emotional and cognitive status …

Comparison Of Dual Enrollment Student Grades In Introductory Biology College Dual-Enrollment Courses Taken In Texas High Schools Or Colleges For School Leaders, Cynthia A. Gallardo

School Leadership Review

Dual Enrollment (DE) or Dual Credit (DC) programs have become increasingly prevalent at both the high school and college settings. These programs enable students to earn both high school and college credit and get a head start on their college education. Additionally, students in these programs must take university core curriculum courses to fulfill their college education requirements. A course that several students take is Introductory to Biology, a STEM (Science, Technology, Engineering, and Mathematics) course. This course is an introductory science course and may present a challenge for students in that there is a large quantity of material discussed. …

Effects Of Delayed Hca Exposure On A Rat Model Of Bipolar Disorder, Eden Comer, Natalie Olander

23rd Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity (2024)

Bipolar disorder (BD) is a neuropsychological disorder featuring cyclical periods of depressive and manic behaviors. The Chase lab aims to develop a reliable animal model for BD in order to characterize its critical neurological triggers. Previous work has shown that daily injection of rat pups from postnatal day 3 through 19 (P3-P19) with homocysteic acid (HCA) produces a mixed manic and depressive state after puberty. These behaviors can be reversed by lithium treatment and involve changes in gene expression in the prefrontal cortex that are also improperly regulated in BD. Despite this model's reproducibility, we observed critical changes in the …

Towards Erasing The Distinction Between The Computational And Syntactic Accounts Of Scientific Theories, Timothy Luft

Theses

One of the main goals of philosophy of science is to give a proper account of scientific theories and their structure. One way that accounts of the structure of scientific theories can be distinguished is by the mathematical or logical structures that they involve. For instance, syntactic accounts of scientific theories hold that theories are axioms in a logical framework, whereas semantic accounts are more liberal in the range of mathematical and logical structures they take as pertinent to the structure of scientific theories. Paul Thagard (1988) offers a computational account of scientific theories, which holds that theories are complex …

Between Fodor And Sellars -- A Middle Ground For Language-Like Neural Representations, Hanzhe Dong

Theses

The recent resurgence of the language of thought (LOT) hypothesis has drawn much attention. The history of philosophy and cognitive science has provided us with various versions of LOT. From Sellars to Fodor, theorists have offered us considerations on the vehicles, content, and functions of such a representation format. However, it’s been more than 50 years since Fodor’s publication on LOT (1975), and the resurgence suggests that we need a modern iteration of LOT to fit with recent developments in the study on cognition. Therefore, in this paper, I argue that we need a middle ground between Fodor and Sellars’s …

New Vertebrate Microfossils Expand The Diversity Of The Chondrichthyan And Actinopterygian Fauna Of The Maastrichtian–Danian Hornerstown Formation In New Jersey, Zachary Boles, Paul V. Ullmann, Ian Putnam, Mariele Ford, Joseph T. Deckhut

School of Earth & Environment Departmental Research

The abundance of shark and actinopterygian fossils in the Cretaceous and Paleogene strata of the Atlantic Coastal Plain is well documented; but much remains unknown about the survivorship patterns of these major components of shallow marine faunas in the western Atlantic through the K/Pg mass extinction. To shed light on this subject, we describe an assemblage of new actinopterygian, chondrichthyan, and reptilian microfossils recently recovered from the Maastrichtian Navesink and Maastrichtian–Danian Hornerstown formations at the Jean and Ric Edelman Fossil Park at Rowan University in Mantua Township, New Jersey. The new microfossils clarify extinction patterns across the K/Pg, create temporal …

Where There’S An Electronic Will, There’S A Way: Evaluating The Potential Power Of Electronically Executed And Stored Wills For Appalachian Communities, Grace Keel Buchanan

Lincoln Memorial University Law Review Archive

Based on the rise of electronic media and the difficulty for lower-income communities, specifically rural Appalachia, to build intergenerational wealth, some states have enacted statutes allowing courts to hold electronically created and stored wills to be held valid. By analyzing the current precedent in the United States and beyond concerning electronic wills and the socioeconomic state of Appalachia, the note argues that states should enact legislation to change the Wills Act to give electronic wills in multiple forms full effect by probate courts as long as they are appropriately attested to electronically. The court should recognize the electronic will as …

The Behavioral Impacts Of Iron Oxide Nanoparticle Exposure On The House Sparrow (Passer Domesticus), John Wenderski, Brooke Fox, Jacob Bergstrom, Olivia Sprys-Tellner, Peyton Hallemann, Sarah Grimes

23rd Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity (2024)

In response to a rapidly growing world population, there has been a dramatic increase in global urbanization and industrialization. With these increases comes increased air pollution, which includes metallic nanoparticles that are small enough to pass through an animal’s blood-gas and blood-brain barriers and cause damage. Some animals show behavioral changes in response to metallic nanoparticle exposure; for example, zinc oxide nanoparticle-exposed chicks displayed less antipredator behavior compared to controls. Additionally, mice injected with silver traveled less and more slowly than controls. Observationally, urban birds, compared to their rural conspecifics, tend to take more risks and explore more, which are …

Lysine 473 Regulates The Activity And Trafficking Of The Cystine/Glutamate Transporter, System XC-, Anna Koppin

23rd Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity (2024)

System x_c^- is a membrane transport system that plays a critical role in mitigating oxidative stress. Past work in our lab has shown that System x_c^- localizes to the plasma membrane allowing for increased activity to support production of antioxidants during oxidative stress. In this study, we sought to determine if post-translational modification (PTM) of the transporter regulates its trafficking. A C-terminal 3KR mutant (K422,472,473R) exhibited decreased membrane localization and activity, suggesting that PTM at one of these sites increases activity. Further, we observed that K473R exhibits a 7 kD decrease in the molecular weight, indicating …

Role Of Intermolecular Interactions Between Nanoparticle Capping Ligands And Hydrogel Surfaces During Sliding, Lauren Buckley, Connor Bovia, Griffin Gleeson

23rd Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity (2024)

Modern treatments for osteoarthritis increasingly involve the use of nanoparticles as drugdelivery systems, but there is little known about the influence of nanoparticle chemical composition and surface chemistry between nanoparticles and soft materials in sliding contact. This work implements cartilage-mimicking polyacrylamide (PAM) hydrogels as a well-studied, fundamental platform. In situ (in a fluid environment) macroscale friction tests as a function of shear rate were conducted with a rheometer with a tribology adapter, controlling for contact pressure. Comparing different nanoparticle compositions, citrate capped metal (gold) nanoparticles exhibited a 50% increase in friction relative to water. With no difference in solution viscosity, …

Former College Athletes' Experiences Of Post-Sport Exercise: How Institutions Can Do Better, Samantha M. Vermeesch, Keegan J. Dekuiper, Madelynn Struck, Christian Clark

23rd Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity (2024)

Former college athletes (FCAs) can exhibit detrimental changes to physical and mental perceptions following sports retirement. Because FCAs no longer engage in regular sports training, they also experience a loss of social support through teammates and coaches, and struggle with enacting their newfound autonomy to exercise. To understand how to help FCAs maintain exercise and health long-term, the purpose of this study is to explore former Division III (DIII) athletes' experiences with exercise maintenance following retirement from sport and graduation from college, and understand their opinions on how their institution could have better prepared them for this transition. Fourteen former …

The Local Is Global: The Science Of Coffee Roasting And Brewing, Elliana Boer

23rd Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity (2024)

Our interdisciplinary project on coffee and justice considered the impact of local choices on global coffee producers from both science and humanities perspectives. The science focused on further improving the quality of specialty coffee to create a higher demand for these upmarket beans, thereby allowing coffee producers to earn a more livable wage. Three experiments were conducted to test specialty coffee best practices. The first focused on the baked defect, which may occur when the rate of rise of bean temperature drops during the roasting process. The roasting process has three phases (drying, Maillard, and development); the second experiment tested …

Notes From The Past Show How Local Variability Can Stymie Urchins And The Rise Of The Reds In The Gulf Of Maine, Jarrett E. K. Byrnes, Andrea Brown, Kate Sheridan, Tianna Peller, Jake Lawlor, Julien Beaulieu, Jenny Munoz

Center for Coastal and Ocean Mapping

The impacts of global change—from shifts in climate to overfishing to land use change—can depend heavily on local abiotic context. Building an understanding of how to downscale global change scenarios to local impacts is often difficult, however, and requires historical data across large gradients of variability. Such data are often not available—particularly in peer reviewed or gray literature. However, these data can sometimes be gleaned from casual records of natural history—field notebooks, data sheet marginalia, course notes, and more. Here, we provide an example of one such approach for the Gulf of Maine, as we seek to understand how environmental …

An Ecology Against The Right. Learning Uncertainty And Humility From Ecosystems, Pierre L. Ibisch, Mona Eikel-Pohen, Elias Iceman, Jake Snelling

Languages, Literatures, and Linguistics - All Scholarship

This article is a translation from the German to English. The title of the original is:

Ibisch, P.L. (2020): Eine Ökologie gegen rechts. Von Ökosystemen Unsicherheit und Demut lernen. In: Leitschuh, H., A. Brunnengräber, P.L. Ibisch, R. Loske, M. Müller, J. Sommer & E.-U. v. Weizsäcker (eds. J. Sommer, P.L. Ibisch, A. Brunnengräber): Ökologie und Heimat. Jahrbuch Ökologie 2021. Hirzel-Verlag, Stuttgart, 191-205.

An Examination Of The Big Five, Mental Illness Stigma, And Crisis Intervention Training, Trista Wolfgram

Theses and Graduate Projects

The number of individuals incarcerated with mental illness continues to grow, and correctional officers may play a critical role in rehabilitation. A correlation analysis was conducted between Big Five personality traits and mental illness stigma to determine whether there is a significant relationship in a sample of state correctional officers who participated in Crisis Intervention Training. A mixed model ANOVA was also conducted to assess whether personality traits impacted levels of mental illness stigma following completion of the training. A moderate negative correlation was found between agreeableness and mental illness stigma. All other findings were not clinically significant, potentially due …

Cross-Contamination Of Crispr Guides And Other Unrelated Nucleotide Sequences Among Commercial Oligonucleotides, Hiroshi Arakawa, Hiromi Miura, Rolen M. Quadros, Masato Ohtsuka, Channabasavaiah B. Gurumurthy

Journal Articles: Genetics, Cell Biology & Anatomy

Custom oligonucleotides (oligos) are widely used reagents in biomedical research. Some common applications of oligos include polymerase chain reaction (PCR), sequencing, hybridization, microarray, and library construction. The reliability of oligos in such applications depends on their purity and specificity. Here, we report that commercially available oligos are frequently contaminated with nonspecific sequences (i.e. other unrelated oligonucleotides). Most of the oligos that we designed to amplify clustered regularly interspersed palindromic repeats (CRISPR) guide sequences contained nonspecific CRISPR guides. These contaminants were detected in research-grade oligos procured from eight commercial oligo-suppliers located in three different geographic regions of the world. Deep sequencing …

Role Of Centrosomal P4.1 Associated Protein (Cpap) In Tumor Suppression, Heena Dave

MUSC Theses and Dissertations

In eukaryotic cells, centrosomes are membrane-less organelles that function as the primary microtubules organizing center with a crucial role in cell division. For accurate bipolar spindle assembly and genetic transmission between generations, fidelity in centriolar duplication is critical. Disruption in this process can cause genomic instability, which could then lead to conditions like aneuploidy, a common feature of various cancers. Among the numerous proteins associated with mammalian centrioles, the centrosomal P4.1 associated protein (CPAP) stands out for its essential role in regulating centriole duplication. Dysfunctions in CPAP have been linked to abnormalities in centriole length that can contribute to conditions …

Chromosomal 3q Amplicon Encodes Essential Regulators Of Secretory Vesicles That Drive Secretory Addiction In Cancer, Xiaochao Tan, Shike Wang, Guan-Yu Xiao, Chao Wu, Xin Liu, Biyao Zhou, Yu Jiang, Dzifa Y. Duose, Yuanxin Xi, Jing Wang, Kunika Gupta, Apar Pataer, Jack A. Roth, Michael P. Kim, Fengju Chen, Chad J. Creighton, William K. Russell, Jonathan M. Kurie

Markey Cancer Center Faculty Publications

Cancer cells exhibit heightened secretory states that drive tumor progression. Here, we identified a chromosome 3q amplicon that serves as a platform for secretory regulation in cancer. The 3q amplicon encodes multiple Golgi-resident proteins, including the scaffold Golgi integral membrane protein 4 (GOLIM4) and the ion channel ATPase secretory pathway Ca2+ transporting 1 (ATP2C1). We show that GOLIM4 recruited ATP2C1 and Golgi phosphoprotein 3 (GOLPH3) to coordinate Ca2+ -dependent cargo loading, Golgi membrane bending, and vesicle scission. GOLIM4 depletion disrupted the protein complex, resulting in a secretory blockade that inhibited the progression of 3q-amplified malignancies. In addition to its role …