Digital Commons Network^™

"Weekly Floral Survey Of Collins Gulf In Savage Gulf State Park During Spring 2023: A Learning Process.”, Ben Thornton, Matthew Gano, Roger Hall Dr., David Steen Dr.

Achieve

Weekly, between February 2 and June 12, 2023 (17 weeks), we attempted to identify most flowering plants, including a few trees, and document their developmental stage and relative abundance. We classified developmental stages as emerging, leafing, flowering, fruiting, and senescent and documented the timing of each stage for all species observed. The relative abundance of each species was estimated as 1, 10, 100, or more than 1000 individuals of each species. One hundred and fifty-seven species were identified over the course of the study. Twenty species were rare, and less than ten individuals were observed. Of these, 20 species were …

Stimulator Of Interferon Genes Pathway Activation Through The Controlled Release Of Stingel Mediates Analgesia And Anti-Cancer Effects In Oral Squamous Cell Carcinoma, Minh Phuong Dong, Neeraja Dharmaraj, Estela Kaminagakura, Jianfei Xue, David G Leach, Jeffrey D Hartgerink, Michael Zhang, Hana-Joy Hanks, Yi Ye, Bradley E Aouizerat, Kyle Vining, Carissa M Thomas, Sinisa Dovat, Simon Young, Chi T Viet

Faculty, Staff and Student Publications

Oral squamous cell carcinoma (OSCC) presents significant treatment challenges due to its poor survival and intense pain at the primary cancer site. Cancer pain is debilitating, contributes to diminished quality of life, and causes opioid tolerance. The stimulator of interferon genes (STING) agonism has been investigated as an anti-cancer strategy. We have developed STINGel, an extended-release formulation that prolongs the availability of STING agonists, which has demonstrated an enhanced anti-tumor effect in OSCC compared to STING agonist injection. This study investigates the impact of intra-tumoral STINGel on OSCC-induced pain using two separate OSCC models and nociceptive behavioral assays. Intra-tumoral STINGel …

A Comparative Study On X-Ray Image Enhancement Based On Neutrosophic Set, Nihal N.Mostafa, Amit Krishan Kumar, Yasir Ali

Sustainable Machine Intelligence Journal

Medical image noise, ambiguity, and fuzziness pose challenges to the medical image analysis process. To lessen these problems, fuzzy sets are utilized; however, they frequently ignore the pixel's spatial context. The neutrosophic set (NS) is employed in picture denoising to get over these restrictions. Neutronosophic theory, in particular the NS Bilateral filter, NS Wiener filter, NS Median filter, NS gaussian filter, and NS rank-ordered filter, is covered in this paper. The Lung-cancer dataset of X-Ray images is used to assess the performance of different denoising techniques. The effectiveness of NS-based denoising techniques over conventional techniques is demonstrated through comparisons with …

“I Cannot Bring A Child Into This World”: Hearing And Writing I Poems With Birthstrike Testimonials, Leola Meynell

The Qualitative Report

BirthStrike for Climate was a UK-based movement whose members “striked” against having children, to demonstrate the desperate need for political action on climate change. In this article, I engage with the Listening Guide (Gilligan & Eddy, 2017) to hear, trace and construct “I poems” with BirthStrike members’ testimonial statements, which were published online between 2019-2020. My analysis focusses on how BirthStrike stories articulate the psychosocial impacts of climate change, particularly in relation to questions about having (and not having) children in times of environmental and social crises. I provide an iteration of how the Listening Guide can be applied to …

Cellular Host Response Sepsis Test For Risk Stratification Of Patients In The Emergency Department: A Pooled Analysis, Hollis R. O'Neal, Roya Sheybani, Chadd K. Kraus, Wesley H. Self, Ajay M. Shah, Christopher B. Thomas, Henry T.K. Tse, Robert Scoggins

School of Medicine Faculty Publications

Objectives: Sepsis is one of the most common, costly, and misdiagnosed conditions in U.S. emergency departments (EDs). ED providers often treat on nonspecific signs, subjective suspicion, or presumption of infection, resulting in over- and undertreatment. An increased understanding of host response has opened a new direction for sepsis diagnostics. The IntelliSep test is a U.S. Food and Drug Administration–cleared cellular host response diagnostic that could help distinguish sepsis in ED settings. Our objective was to evaluate the potential of the cellular host response test to expedite appropriate care for patients who present with signs of infection. Methods: We performed a …

Biomechanics Of Transduction By Mechanosensory Cilia For Prey Detection In Aquatic Organisms, Faye Piephoff, Brian K. Taylor

Faculty Scholarship

Surface-feeding aquatic animals navigate towards the source of water disturbances and must differentiate prey from other environmental stimuli. Medicinal leeches locate prey, in part, using a distribution of mechanosensory hairs along their body that deflect under fluid flow. Leech's behavioral responses to surface wave temporal frequency are well documented. However, a surface wave's temporal frequency depends on many underlying environmental and fluid properties that vary substantially in natural habitats (e.g., water depth, temperature). The impact of these variables on neural response and behavior is unknown. Here, we developed a physics-based leech mechanosensor model to examine the impact of environmental and …

Depletion Of Protein Phosphatase 1 Results In Persistent Activation Of The Integrated Stress Response And Age-Associated Exacerbation Of Pulmonary Veno-Occlusive Disease, Amit Prabhakar, Meetu Wadhwa, Prajakta Ghatpande, Rahul Kumar, Brian B. Graham, Giorgio Lagna, Akiko Hata

Biology

Pulmonary veno-occlusive disease (PVOD) is a form of pulmonary hypertension that affects individuals across the age spectrum. PVOD is characterized by the obstruction of small pulmonary vessels, causing increased pulmonary artery (PA) pressure and leading to right ventricular heart (RV) failure. Previous research showed that the administration of Mitomycin-C (MMC) in rats mediates PVOD through the activation of the eukaryotic initiation factor 2 (eIF2) kinase PKR and the integrated stress response (ISR), resulting in the impairment of vascular endothelial junctional structure and barrier function. In this study, we reveal that older rats experience more severe pulmonary vascular remodeling and RV …

Autoethnographies Exploring The Cultural Spirit Murdering And Nurturing Of Three Minority Educators In K-12, Sara Z. Beg, Maritza Caldera, Denise Ross

Dissertations

This autoethnography sought to understand how our experiences during our K-12 journey as three minority students shaped our identities as students and our teaching style today. An autoethnography allowed us to analyze our experiences through the lens of Cultural Spirit Nurturing and Cultural Spirit Murdering. Cultural Spirit Nurturing, as we defined it, is the acceptance, respect, and inclusion of different cultures, ethnicities, nationalities, races, languages, and religions in society. We dissected our lived moments as Pakistani Muslim American, African American, and Mexican American students turned educators, defined them as Cultural Spirit Nurturing or Murdering, and bridged them with the concepts …

Faa Medical Reform, Dana Rose

Honors Projects

This project investigates the challenges and implications of obtaining medical certification for pilots with a history of childhood misdiagnoses, focusing on Attention-Deficit/Hyperactivity Disorder (ADHD). Misdiagnoses in childhood can lead to significant obstacles in the aviation industry's medical certification process, posing unique hurdles for aspiring pilots. The study examines the current FAA guidelines and procedures for medical certification, particularly the evaluation requirements for individuals with ADHD. It also explores common challenges faced by pilots, the effects of childhood misdiagnoses on their eligibility, and the impact of the FAA's ADHD evaluation process.

Through interviews with Aviation Medical Examiners (AMEs), this project identifies …

A Review Of Consanguinity In The Iraqi Population: A Call To Action To Prevent A Future Health Catastrophe, Zaid Ali Hawi, Kealan Pugsley, Atefeh Namipashaki, Walied Samarrai, Ziarih Hawi

Publications and Research

Although not uncommon worldwide, consanguinity has been a part of Arab culture and tradition as a means to strengthen tribal blood relations. However, this type of union has been linked to inherited diseases, particularly those of a recessive nature (e.g., hemoglobinopathies). Furthermore, several recent studies have documented highly significant associations between consanguineous parentage and common multifactorial diseases, including but not limited to hypertension, mental disorders, and several cardiovascular diseases. In Iraq, the prevalence of consanguinity is very high and still on the rise. This has resulted in an increased prevalence of inherited diseases and has significant negative impacts on Iraq’s …

Artsksu Presents: An Evening With Composer David Biedenbender

Bailey School of Music Concert Programs

featuring:

KSU Wind Symphony | Daniel Lee, Conductor

KSU Wind Ensemble | David Kehler, Conductor

Brandon Meeks, Guest Conductor

The Bengali Oil-Eaters: A Speculative Approach To New Materialism And The Nonhuman In Contemporary Petrofiction, Jenna Wayland

Honors Projects

Despite oil’s heavy saturation within the context of contemporary global life, novelistic registrations of oil frontiers and extractive drilling in contemporary world literature remain proportionally barren with regards to oil’s political and geographical importance across the world-system. Petro-cultural production, transnational in scale and imposing in material basis, relegates oil to a paradoxical literary deferment. The general invisibility of petrofiction within the petro-sphere suggests that the materialist basis of petroleum and its fraught geopolitical history has culturally transformed oil into a repressed, peripheral, and hidden material that subsequently renders the oil-encounter unseen in contemporary literature. This creative synthesis of the oil-encounter …

The Dual-Targeted Fusion Inhibitor Clofazimine Binds To The S2 Segment Of The Sars-Cov-2 Spike Protein, Matthew Freidel, Pratiti Vakhariya, Shalinder Sardarni, Roger Armen

College of Pharmacy Faculty Papers

Clofazimine and Arbidol have both been reported to be effective in vitro SARS-CoV-2 fusion inhibitors. Both are promising drugs that have been repurposed for the treatment of COVID-19 and have been used in several previous and ongoing clinical trials. Small-molecule bindings to expressed constructs of the trimeric S2 segment of Spike and the full-length SARS-CoV-2 Spike protein were measured using a Surface Plasmon Resonance (SPR) binding assay. We demonstrate that Clofazimine, Toremifene, Arbidol and its derivatives bind to the S2 segment of the Spike protein. Clofazimine provided the most reliable and highest-quality SPR data for binding with S2 over the …

Wild Seahorse Conservation And Industrial Growth Strategies: A Dual-Perspective Study, Shicheng Wang, Bo Li, Lanliang Yu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The United Nations Decade of Ocean Science for Sustainable Development (2021–2030) prioritizes healthy oceans and sustainable development. Protecting marine biodiversity, promoting sustainable fisheries, and achieving global sustainability goals are critical concerns for the international community. This study addresses critical challenges in seahorse conservation and industrial development, including wild resource depletion, limitations in aquaculture technology, low-value industrial chains, and inadequate regulatory coordination. Through systematic analysis of current conservation status and industrial trends, establishing demonstration bases is proposed for seahorse resource protection and high-value utilization ("Hippocampus Hub"), guided by natural habitat integrity, scientific research capacity, industrial chain integration, and policy support. By …

Strategic Pattern And Optimization Of China's Eco-Regions During Fifteenth Five-Year Plan Period, Kan Zhou, Jie Fan, Daojing Zhou, Zhedong Qian, Hu Yu, Hanchu Liu, Jian Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Since the implementation of the major function oriented zoning, the ecological space of key ecological functional areas has continuously expanded, with a significant increase in vegetation coverage. Concurrently, there has been a dual change in population dynamics, characterized by a decrease in total population and an increase in the urban population. Furthermore, significant achievements have been made in economic and social development, and there has been a steady improvement in the functions of ecological security barriers, contributing to an alleviation of tension in human-environment relationships. During the 15th Five-Year Plan period, it is imperative to adhere to the functional orientation …

Th2 Cells Are Associated With Tumor Recurrence Following Radiation, Mohamed K Abdelhakiem, Riyue Bao, Phillip M Pifer, David Molkentine, Jessica Molkentine, Andrew Hefner, Beth Beadle, John V Heymach, Jason J Luke, Robert L Ferris, Curtis R Pickering, Jing H Wang, Ravi B Patel, Heath D Skinner

Faculty, Staff and Student Publications

The curative treatment of multiple solid tumors, including head and neck squamous cell carcinoma (HNSCC), utilizes radiation. The outcomes for HPV/p16-negative HNSCC are significantly worse than HPV/p16-positive tumors, with increased radiation resistance leading to worse locoregional recurrence (LRR) and ultimately death. This study analyzed the relationship between immune function and outcomes following radiation in HPV/p16-negative tumors to identify mechanisms of radiation resistance and prognostic immune biomarkers. A discovery cohort of 94 patients with HNSCC treated uniformly with surgery and adjuvant radiation and a validation cohort of 97 similarly treated patients were utilized. Tumor immune infiltrates were derived from RNAseq gene …

Anthropogenic Noise Limits Resource Distribution Without Changing Social Hierarchies, S. Tidau, Mark Briffa

School of Biological and Marine Sciences

Increasing evidence demonstrates that anthropogenic noise is a global pollutant that threatens marine ecosystems. Mounting numbers of studies show its diverse effects on individuals and their behaviour. However, little is known about how individual changes in response to anthropogenic noise could cascade through groups and populations affecting resource distribution vital for survival and fitness. Here we test the hypotheses that anthropogenic noise could alter resource distribution, associated hierarchies and consequently individual benefits. We used groups of hermit crabs, a globally distributed model system for assessing impacts of environmental change on wildlife and measured in controlled laboratory conditions the resource distribution …

Annotated Supplement To The Commander's Handbook On The Law Of Naval Operations

International Law Studies

The Commander’s Handbook on the Law of Naval Operations is used in the United States and throughout the world as a restatement of U.S. doctrinal law positions on matters affecting the operations of the U.S. Navy, the U.S. Marine Corps, and the U.S. Coast Guard. Judge advocates and legal advisers have occasion to conduct deeper research to identify the context and source of the rules reflected in the Commander’s Handbook. Responding to this need, an Annotated Supplement to The Commander’s Handbook was produced in 1997 and published as volume 73 of International Law Studies. In the intervening decades, …

Contemporary Mythology: Poems Of Creatures And Grievances, Zane G. Segal

University of Montana Conference on Undergraduate Research (UMCUR)

Urban legends and modern folklore have never been popular subjects in the canon of serious poetry, despite their more ancient counterparts being frequently coveted content. In a post-science world, the uncanny hearsay of yesteryear has lost its star power, and the act of believing in such myths has been relegated to an embarrassing pastime of drunk uncles and gullible dimwits. However, Contemporary Mythology is a collection of poems which are not afraid to be embarrassed. By entertaining the lovable qualities of unlovable monsters, these poems seek the resonance which keep urban legends comfortably lodged in the backlogs of American culture. …

The Effect Of Livestock Grazing On Sharp-Tailed Grouse Nesting, Abigail I. League

University of Montana Conference on Undergraduate Research (UMCUR)

This past summer, I worked for Montana Fish, Wildlife, and Parks on the first reintroduction effort of sharp-tailed grouse to western Montana following their extirpation from the region in the late 2000s. I was monitoring nest success, specifically in the Blackfoot Valley, and it was apparent that the nest survival rate was considerably low. Researchers do not know the exact reason sharp-tailed grouse were originally extirpated from the region. However, it has been hypothesized that the use of proper livestock grazing practices could be an important factor in increasing the probability of successfully establishing a population. For this project, I …

A Comparison Of Mammal Detection Methods: Hair Snares Vs Wildlife Cameras, Rayne G. Mccollough

University of Montana Conference on Undergraduate Research (UMCUR)

This study presents findings from a multi-year mammal inventory project conducted by the Bosque School Field and Community Science Programs and partners. The research compares the efficacy of wire brush hair snares and camera traps as mammal detection methods within a 9-hectare property recently acquired by the City of Albuquerque Open Space Division, known as the Bosque. This study was prompted by the request of Albuquerque Open Space biologists and planners to conduct a comprehensive wildlife inventory of the Property and its adjacent public open space. Through rigorous methodology and data analysis, this research sheds light on the comparative effectiveness …

Earlier Snowmelt Adversely Affects Alpine Plant Reproduction, August Lawson, Megan Demarche, Meredith Zettlemoyer

University of Montana Conference on Undergraduate Research (UMCUR)

Alpine ecosystems, a high-elevation habitat found above treeline, are experiencing rapid rates of climate change. Climate change results in warmer, drier conditions and increasingly early snowmelt. However, we have a limited understanding of how climate change affects alpine plant population dynamics, including flower, fruit, and seed production. Recent evidence suggests that seed production declines as snow melt occurs earlier. In summer 2023, we monitored populations of three alpine plants, Minuartia obtusiloba, Phlox condensata, and Silene acaulis. These three species are long-lived, low-growing cushion plants commonly found in alpine habitats across the globe. We quantified fruit production of these …

Understanding The Role Of Maternal-Fetal Tissue Communication In The Evolution Of Genomic Imprinting And Disruption Of Placental Development, Ashlin K. Slanger

University of Montana Conference on Undergraduate Research (UMCUR)

Understanding the role of maternal-fetal tissue communication in the evolution of genomic imprinting and disruption of placental development

Ashlin Slanger¹, John Statz¹, Fernando Rodriguez¹, Jeff Good¹

¹Division of Biological Sciences, University of Montana

The placenta is a fast-evolving organ in mammals and has been hypothesized to be a hotspot for the evolution of genomic imprinting. Imprinted expression is a form of gene regulation by which some genes show parent-of-origin dependent allelic expression bias and is critical for successful mammalian development. Studies of placental gene expression in hybridizations between mouse species have shown disruption of placental expression in several genes including …

Evolution Of Thermal Performance In A Geographically Widespread Marine Cyanobacterium, Nathan Ryan Miller

University of Montana Conference on Undergraduate Research (UMCUR)

Temperature is one of the most important factors that affect the growth and activity of organisms. Temperatures of coastal marine environments, in particular, vary greatly based on latitude and the local environment (i.e., bays, estuaries, water depth). The Chlorophyll d-producing cyanobacterium, Acaryochloris marina, is widely distributed in shallow, intertidal marine environments enriched in far-red light, but our understanding of its temperature preferences is limited. In this study, we investigated how different temperatures affect the growth of nine A. marina laboratory strains that were isolated from locations that experience distinct differences in mean sea surface temperature. We hypothesized that the …

Drought-Defying Blooms: Mt. Jumbo Wildflowers Accelerate Flowering In Response To Climate Change, Delia Schmidt, Peter Lesica, Meredith Zettlemoyer

University of Montana Conference on Undergraduate Research (UMCUR)

As our planet undergoes unprecedented climatic shifts, we are beginning to see profound impacts on ecological processes. For example, in western Montana, we expect warming temperatures, altered precipitation, and increasing drought. Both warmer and drier conditions can affect phenology, or the timing of biological events (e.g., flowering). Indeed, earlier flowering is a well-documented consequence of warming temperatures. However, evidence for phenological shifts in response to changing precipitation remains scarce. Using a 29-year dataset on flowering time in a wildflower community on Mt. Jumbo, Missoula, MT, we examined the impacts of warming temperatures and drought conditions on flowering time in species …

The Effects Of Temperature On Bromus Tectorum (Cheatgrass) Seed Germination, Patrick White, Abby Mcmurtry, Akasha Faist

University of Montana Conference on Undergraduate Research (UMCUR)

Bromus tectorum (Cheatgrass) is an invasive winter annual grass from Eurasia that heavily impacts the intermountain west of North America. B. tectorum invades and changes the fire cycle by making it more intense and frequent by adding continuous fuels to the landscape. This study explores how heat from seasonal fire paired with extreme cold temperatures impacts B. tectorum germination. The hypothesis is that extreme cold temperatures and temperatures simulating grassland fires will impact B. tectorum seeds by decreasing the germination rate and ultimately affecting abundance. When seeds experience cold and heat treatments independently, a lower germination rate is expected relative …

Deeply Rooted: The Role Of Indigenized Research Approaches In Camas Restoration Ecology, Tessa Grace Jarden

University of Montana Conference on Undergraduate Research (UMCUR)

Despite being one of the most culturally significant and historically abundant native plants of the Pacific Northwest, common camas (Camassia quamash (Pursh) Greene) has undergone a precipitous decline across its range. This decline, driven primarily by agricultural land-use conversion and wetland drainage, has disproportionately impacted Indigenous peoples for whom camas is a cultural keystone species. For thousands of years prior to colonization, tribes across the Pacific Northwest relied on camas bulbs as a first food and managed camas prairies using Traditional Resource Management (TRM) practices. Camas restoration has emerged as a widespread management priority in recent years, particularly among …

Exposure To The Trier Social Stress Test Enhances Central Detail Memory, Reduces False Memory, And Results In Intrusive Memories That Last For Days, Mercedes L. Stanek, Kayla Boaz, Taylor D. Niese, Kristen E. Long, Matthew S. Risner, John G. Blasco, Koen N. Suzelis, Kelsey M. Siereveld, Boyd R. Rorabaugh, Phillip R. Zoladz

ONU Student Research Colloquium

Recent work has used a modified version of the well-known laboratory stressor, the Trier Social Stress Test (TSST), to study participant memory for a stressful experience. The paradigm is useful because, unlike most studies examining stress effects on memory, it allows investigators to measure what participants remember about the stressor, not unrelated information. It also presents an opportunity to model other stress-related symptoms, such as intrusive memories, but these have yet to be assessed with this paradigm. Intrusive memories have been notoriously difficult to measure in laboratory settings; most of this research involves participants watching arousing videos and subsequently reporting …

Disorganization Chart: Troubling Corporate Decision-Making On Succession, Lisa Siraganian

DePaul Law Review

No abstract provided.

Frames, Fiends, Feelings And Family: Succession’S Affect And The Law School Classroom, Gillian Calder, Rebecca Johnson

DePaul Law Review

No abstract provided.