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020-Investigating Spread Rates Of Aquatic Invasive Plant Species In North America, Morgan Ladue Apr 2024

020-Investigating Spread Rates Of Aquatic Invasive Plant Species In North America, Morgan Ladue

GREAT Day Posters

Aquatic invasive species have detrimental effects on the ecosystems of the Northeastern United States and Canada. Characterizing the patterns of invasion for aquatic invasive species can be important for making local management decisions to control them. We focused onNajas minor(Brittle Waternymph),Hydrilla verticillata(Hydrilla), andNitellopsis obtusa(Starry Stonewort). To characterize their patterns of invasion, we first compiled occurrence records ofN. minor,H. verticillata, andN. obtusafrom the online databases GBIF, iDigBio, and iMapInvasives. We then used QGIS to estimate the ranges (in lake surface area), at different intervals of time, for each species since their arrival in North America. Finally, we calculated the spread rates …

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Justification And Roadmap For Artificial Intelligence (Ai) Literacy Courses In Higher Education, Sunil Hazari Apr 2024

Justification And Roadmap For Artificial Intelligence (Ai) Literacy Courses In Higher Education, Sunil Hazari

Journal of Educational Research and Practice

This paper presents a justification for the implementation of AI Literacy courses in higher education. Ethical concerns and biases surrounding AI technologies are explored, highlighting the importance of critical analysis and responsible use of AI. A conceptual framework is then proposed, focusing on awareness, skill development, and practical application of AI. This framework aims to foster comprehensive understanding and empower students to leverage AI's potential while mitigating risks. The paper provides sample course titles and learning objectives. The suggested course format covers AI concepts, ethical considerations, bias awareness, and practical prompt engineering skills. There is a need for integrating AI …

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Diurnal Immune Cell Migration Patterns Characterized In The Spaceflight Environment, Angela Cebula, Marissa Burke, Erik Larsen, Kaylin Juarez, Carol Mitchell, Cassandra M. Juran, Candice G. T. Tahimic, Stephanie Tabares Ruiz, Janani Iyer, Stephanie Puukila, Siddhita D. Mhatre, Joshua S. Alwood, Marianne B. Sowa, April E. Ronca, Amber M. Paul Apr 2024

Diurnal Immune Cell Migration Patterns Characterized In The Spaceflight Environment, Angela Cebula, Marissa Burke, Erik Larsen, Kaylin Juarez, Carol Mitchell, Cassandra M. Juran, Candice G. T. Tahimic, Stephanie Tabares Ruiz, Janani Iyer, Stephanie Puukila, Siddhita D. Mhatre, Joshua S. Alwood, Marianne B. Sowa, April E. Ronca, Amber M. Paul

Discovery Day - Daytona Beach

Daily diurnal immune rhythm shapes biological pathways of organisms and closely aligns with optimizing energy usage in response to environmental light-dark cycles. Immune mobilization depends on diurnal signals to regulate immunity. In spaceflight, disrupted circadian rhythms and immune systems are noted. However, crosstalk between these systems has not been fully characterized. To fill this knowledge gap, we utilized a ground-based model of spaceflight to phenotype diurnal immunity in mice. For this, 24-week-old male and female mice were exposed to a combination of single-housed, acute 15cGy 5-ion GCRsim irradiation and continuous hindlimb unloading for 2 weeks on a light:dark [12hr:12hr] cycle …

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Rising Cases Of Drug-Induced Pulmonary Fibrosis: Analysis Of The Food And Drug Administration Adverse Event Reporting System (Faers) Database, 2000–2022, Kenneth L. Mccall, Kelsey R. Hennig, Zachary T. Abe, Danielle N. Dattler, Karyssa L. Hurd, Sophie L. Portnoy, Zoey J. Zagoria Apr 2024

Rising Cases Of Drug-Induced Pulmonary Fibrosis: Analysis Of The Food And Drug Administration Adverse Event Reporting System (Faers) Database, 2000–2022, Kenneth L. Mccall, Kelsey R. Hennig, Zachary T. Abe, Danielle N. Dattler, Karyssa L. Hurd, Sophie L. Portnoy, Zoey J. Zagoria

Pharmacy Faculty Scholarship

Purpose Pulmonary fibrosis (PF) is a severe, progressive disease, which may be caused by exposure to certain medications. Methods We queried the U.S. FDA Adverse Event Reporting System (FAERS) from 2000 to 2022, using the search terms “pulmonary fibrosis” and “idiopathic pulmonary fibrosis” and excluded reports with patients under the age of 18 years, and patients with unknown sex or age. Reports were sorted by generic drug names, counted, and plotted over time using a best-fit trendline based on an exponential function. Results From 2000 to 2022, there were 24 095 935 adverse drug events reported in FAERS, of which …

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Developing A Novel Assay For Quantifying Allelopathy Tolerance In Soybeans To Pennycress Glucosinolates In A Controlled Environment, A. Jonaus Apr 2024

Developing A Novel Assay For Quantifying Allelopathy Tolerance In Soybeans To Pennycress Glucosinolates In A Controlled Environment, A. Jonaus

Biology Honors Projects

In a pennycress (Thlaspi arvense L.) and soybean (Glycine max L.) relay-cropping system, one concern for farmers is the effects of pennycress allelochemicals on soybean growth and yield. Pennycress root exudates are known to contain sinigrin, a glucosinolate which hydrolyzes to form the harmful compound allyl isothiocyanate (AITC). In addition to serving as defense against herbivory, glucosinolates are also known to have allelopathic effects on surrounding plants by possibly affecting traits like germination, biomass accumulation, nutrient uptake, mycorrhizal symbioses, and nitrogen fixation. This is not ideal in a relay cropping system, where the presence of pennycress can decrease soybean yields …

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The Utah Statesman, April 29, 2024, Utah State University Apr 2024

The Utah Statesman, April 29, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

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Multihalle Pavilion: The Renovation Of An Innovative, Experimental Structure From The 1970s, Steffen Lehmann Apr 2024

Multihalle Pavilion: The Renovation Of An Innovative, Experimental Structure From The 1970s, Steffen Lehmann

Architecture Faculty Research

This article discusses the significance and challenges of renovating a unique 1970s experimental timber building and iconic structure: the Multihalle Pavilion in Mannheim (Germany), which has the world’s first and largest self-supporting wooden grid shell roof structure. Originally conceived as a temporary structure for the 1975 Federal Garden Exposition, Multihalle uses a lattice grid shell structure with gentle curves, remarkably slim profiles, and a translucent roof. The term ‘grid shell’ refers to a doubly curved surface formed from the lattice of timber with uniform spacing in two directions. Furthermore, this was one of the first buildings in Germany whose plan …

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“You Have To First Recognize That There’S A Problem Before You Can Enact Change”: A Mixed-Methods Study Of General And Special Education Co-Teachers’ Critical Consciousness And Agency In Enacting Socially Just Inclusive Practices, Latifa Sebti Apr 2024

“You Have To First Recognize That There’S A Problem Before You Can Enact Change”: A Mixed-Methods Study Of General And Special Education Co-Teachers’ Critical Consciousness And Agency In Enacting Socially Just Inclusive Practices, Latifa Sebti

Theses and Dissertations

Inclusive education transcends the physical integration of students with disabilities in inclusive classrooms, demanding a commitment toward socially just inclusive practices. The purpose of this exploratory mixed-methods study is to investigate inclusive co-teachers' critical consciousness and agency in socially just inclusive practices, specifically for students of color with disabilities. The quantitative phase, with a survey of 241 teachers, revealed a structural equation model showing relationships between critical awareness about intersectionality, attitudes toward inclusion, self-efficacy in inclusive teaching, agency, and critical action. The open-ended responses indicated two teacher profiles based on their level of critical consciousness. The qualitative phase included interviews …

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Notes On North American Butterflies, 1, Harry Pavulaan Apr 2024

Notes On North American Butterflies, 1, Harry Pavulaan

The Taxonomic Report of the International Lepidoptera Survey

New natural history elements and distribution records of several North American butterflies are reported. Taxonomy is often driven by geographical analyses. Cartography, coupled with internet-based imagery, opens up a promising wealth of information, allowing avocational researchers a tool by which inconvenient visits to institutional collections are no longer necessary for resolving some basic questions. While diversity and distribution of butterflies in North America are commonly believed to be fully known, the findings presented here show that much is yet to be learned of our butterfly fauna.

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Uganda Humanitarian Violence Against Children And Youth Survey, 2022: Summary Report, Francis Obare Onyango, George Odwe, Peter Kisaakye, Stephen Kizito, Yohannes Dibaba Wado, Francis Annor, Laura Chiang, Greta Massetti, Stella Muthuri, Gloria Seruwagi, Darlson Kusasira, Charles Bafaki, Katie Ogwang, Chi-Chi Undie Apr 2024

Uganda Humanitarian Violence Against Children And Youth Survey, 2022: Summary Report, Francis Obare Onyango, George Odwe, Peter Kisaakye, Stephen Kizito, Yohannes Dibaba Wado, Francis Annor, Laura Chiang, Greta Massetti, Stella Muthuri, Gloria Seruwagi, Darlson Kusasira, Charles Bafaki, Katie Ogwang, Chi-Chi Undie

Humanitarian Task Force

Violence Against Children (VAC) refers to all forms of abuse or maltreatment of people under the age of 18 years. The Violence Against Children and Youth Surveys (VACS), led by national governments with technical assistance from the U.S. Centers for Disease Control and Prevention (CDC) as part of the Together for Girls partnership, have documented the magnitude and prevalence of physical, emotional, and sexual violence against children in more than 20 low- and middle-income countries, with a view to informing national prevention and response programs. Despite the precedent for understanding the extent of VAC from the perspectives of adolescents and …

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Teacher Efficacy In Co-Teaching Science Classrooms: Implications For Training, Sabrina Christensen Apr 2024

Teacher Efficacy In Co-Teaching Science Classrooms: Implications For Training, Sabrina Christensen

Departmental Honors & Graduate Capstone Projects

Following legislation to educate students in the least restricted environment, schools are using co-taught inclusive settings to teach secondary science classrooms. Traditionally, general educators do not receive robust instruction in differentiation, co-teaching, or collaboration with special educators. Special educators traditionally do not receive training in science content. An online survey was distributed through social media inviting teachers to share their experiences with co-teaching in science classrooms. Likert scales were used to measure teacher efficacy in co-teaching secondary science classes and teacher perceptions of the effectiveness of current teacher training. Based on the data collected, recommendations are provided for adjustments to …

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Monitoring Selenium Bioaccumulation In False Map Turtles (Graptemys Pseudogeographica), Grant M. Budden Apr 2024

Monitoring Selenium Bioaccumulation In False Map Turtles (Graptemys Pseudogeographica), Grant M. Budden

Honors Thesis

Selenium is an element that becomes bioactivated in aquatic environments. Selenium bioaccumulation may threaten a South Dakota state-threatened species, the False Map Turtle (Graptemys pseudogeographica). Invertebrate filter feeder species like zebra mussels (Dreissena polymorpha) uptake selenium via exposure. Previous laboratory work has found that False Map Turtles consume large amounts of zebra mussels throughout the summer, leading to selenium bioaccumulation from selenium transfer from prey to predator. A myriad of adverse effects, like selenosis, reproductive infertility, and death, are associated with high selenium concentrations. Sampling was completed on False Map Turtles in the summer of 2022. …

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The Minutes Of The Marshall University Graduate Council Meeting, April 29, 2024, Marshall University Graduate Council Apr 2024

The Minutes Of The Marshall University Graduate Council Meeting, April 29, 2024, Marshall University Graduate Council

Graduate Council Minutes

No abstract provided.

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Antimicrobial Activity Of Cat Flea (Ctenocephalides Felis) Gut Proteins On Different Days After Blood Feeding, Dhruva K. Karnik Apr 2024

Antimicrobial Activity Of Cat Flea (Ctenocephalides Felis) Gut Proteins On Different Days After Blood Feeding, Dhruva K. Karnik

Honors College Theses

Cat fleas (Ctenocephalides felis) are a blood-feeding ectoparasitic insect and a common domestic pest found throughout the world. Because of their reliance on host blood, fleas are exposed to blood-borne pathogens; however, the flea gut lumen is a hostile environment for microbial colonization. For example, the gut epithelia differentially express immune genes in response to feeding. In the present study, we measured the antimicrobial activity of gut proteins from cat fleas at different days after feeding (2, 5, 7, and 14). Dissected flea guts were homogenized, passed through a syringe filter, and measured in a protein assay kit. …

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Snow Avalanches Are A Primary Climate-Linked Driver Of Mountain Ungulate Populations, Kevin S. White, Eran Hood, Gabriel J. Wolken, Erich H. Peitzsch, Yves Bühler, Katreen Wikstrom Jones, Chris T. Darimont Apr 2024

Snow Avalanches Are A Primary Climate-Linked Driver Of Mountain Ungulate Populations, Kevin S. White, Eran Hood, Gabriel J. Wolken, Erich H. Peitzsch, Yves Bühler, Katreen Wikstrom Jones, Chris T. Darimont

Faculty, Staff, and Students

Snow is a major, climate-sensitive feature of the Earth’s surface and catalyst of fundamentally important ecosystem processes. Understanding how snow influences sentinel species in rapidly changing mountain ecosystems is particularly critical. Whereas effects of snow on food availability, energy expenditure, and predation are well documented, we report how avalanches exert major impacts on an ecologically significant mountain ungulate - the coastal Alaskan mountain goat (Oreamnos americanus). Using long-term GPS data and field observations across four populations (421 individuals over 17 years), we show that avalanches caused 23−65% of all mortality, depending on area. Deaths varied seasonally and were directly linked …

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Sex Matters The Impact Of Skin Tone On Perceived Levels Of Attraction, Callie Vitro, Talisa J. Carter Apr 2024

Sex Matters The Impact Of Skin Tone On Perceived Levels Of Attraction, Callie Vitro, Talisa J. Carter

Criminology and Criminal Justice Faculty Publications

Research finds that individuals of dark complexions are more likely to face prejudice or be discriminated against in a variety of contexts. Referred to as colorism, skin-tone-based discrimination has major implications for various life outcomes. Research on social interactions suggests that lighter skin tones are associated with a higher level of physical attractiveness, which is of particular interest for this study. This study uses quantitative survey data collected from undergraduate and graduate students from across the United States to explore the relationship between colorism, gender, and perceived physical attraction via a modified version of Harvey, Tennial, and Bank’s In-Group Colorism …

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Pathogenesis And Therapeutic Considerations For Nonalcoholic Fatty Liver Disease, Elijah Chung Apr 2024

Pathogenesis And Therapeutic Considerations For Nonalcoholic Fatty Liver Disease, Elijah Chung

Senior Honors Theses

A product of the Westernized, high-fat diet, non-alcoholic fatty liver disease (NAFLD) has emerged as the leading cause of chronic liver disease, affecting one-fourth of the world's population. NAFLD is a progressive disease arising from a multisystem response to excess lipids in the blood, adipose tissue, and liver. Despite the prevalence of NAFLD and its well-studied bidirectional association with obesity and type 2 diabetes mellitus and obesity, there is a shocking scarcity of available treatments aside from diet and lifestyle changes. Thus, further research on NAFLD and potential therapies is urgently needed. This paper will illustrate the major pathways associated …

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How Do Men And Women View Stress Differently?, Ayrianna Ring Apr 2024

How Do Men And Women View Stress Differently?, Ayrianna Ring

Psychology Student Publications

No abstract provided.

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Interaction Of High-Fat Diet And Brain Trauma Alters Adipose Tissue Macrophages And Brain Microglia Associated With Exacerbated Cognitive Dysfunction, Rebecca J Henry, James P Barrett, Maria Vaida, Niaz Z Khan, Oleg Makarevich, Rodney M Ritzel, Alan I Faden, Bogdan A Stoica Apr 2024

Interaction Of High-Fat Diet And Brain Trauma Alters Adipose Tissue Macrophages And Brain Microglia Associated With Exacerbated Cognitive Dysfunction, Rebecca J Henry, James P Barrett, Maria Vaida, Niaz Z Khan, Oleg Makarevich, Rodney M Ritzel, Alan I Faden, Bogdan A Stoica

Faculty, Staff and Student Publications

Obesity increases the morbidity and mortality of traumatic brain injury (TBI). Detailed analyses of transcriptomic changes in the brain and adipose tissue were performed to elucidate the interactive effects between high-fat diet-induced obesity (DIO) and TBI. Adult male mice were fed a high-fat diet (HFD) for 12 weeks prior to experimental TBI and continuing after injury. High-throughput transcriptomic analysis using Nanostring panels of the total visceral adipose tissue (VAT) and cellular components in the brain, followed by unsupervised clustering, principal component analysis, and IPA pathway analysis were used to determine shifts in gene expression patterns and molecular pathway activity. Cellular …

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Systematic Reviews In The Engineering Literature: A Scoping Review, Margaret Phillips, Jason B. Reed, Dave Zwicky, Amy S. Van Epps, Amy G. Buhler, Erin M. Rowley, Qianjin Zhang, James M. Cox, Wei Zakharov Apr 2024

Systematic Reviews In The Engineering Literature: A Scoping Review, Margaret Phillips, Jason B. Reed, Dave Zwicky, Amy S. Van Epps, Amy G. Buhler, Erin M. Rowley, Qianjin Zhang, James M. Cox, Wei Zakharov

Purdue University Libraries Open Access Publishing Fund

A systematic review is a specialized type of literature review used to collect and synthesize all the available evidence related to a research question. The methods for systematic reviews should be transparent and reproducible so that other researchers can use, replicate, and build upon the findings. Systematic reviews have been published for decades in medical literature where it is necessary to bring together all the studies related to a particular disease or condition for healthcare professionals to make evidence-based recommendations. Conducting systematic reviews has expanded to other disciplines, including education, business, and engineering. The authors of this study conducted a …

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Towards Accessible Futures: Re-Imagining Space And Inclusion In Higher Education, Cecelia Kaufmann Apr 2024

Towards Accessible Futures: Re-Imagining Space And Inclusion In Higher Education, Cecelia Kaufmann

Geography Honors Projects

Since the Americans with Disabilities Act (ADA), an increased number of people with disabilities have participated in higher education, yet their experiences continue to differ from their able-bodied peers. This thesis considers these differences utilizing Dolmage’s academic ableism, Foucault’s theory of Biopower, and Lefebvre’s theory on the Production of Space. This research shows how physical infrastructure and levels of power reproduce instances of academic ableism. Utilizing a case study of a private college in Minnesota, this research draws on interviews with stakeholders, offering guidance to correct the broader social and physical exclusions created that people with disabilities encounter in higher …

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Kinetics-Based Inference Of Environment-Dependent Microbial Interactions And Their Dynamic Variation, Hyun-Seob Song, Na-Rae Lee, Aimee K. Kessell, Hugh C. Mccullough, Seo-Young Park, Kang Zhou, Dong-Yup Lee Apr 2024

Kinetics-Based Inference Of Environment-Dependent Microbial Interactions And Their Dynamic Variation, Hyun-Seob Song, Na-Rae Lee, Aimee K. Kessell, Hugh C. Mccullough, Seo-Young Park, Kang Zhou, Dong-Yup Lee

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Microbial communities in nature are dynamically evolving as member species change their interactions subject to environmental variations. Accounting for such context-dependent dynamic variations in interspecies interactions is critical for predictive ecological modeling. In the absence of generalizable theoretical foundations, we lack a fundamental understanding of how microbial interactions are driven by environmental factors, significantly limiting our capability to predict and engineer community dynamics and function. To address this issue, we propose a novel theoretical framework that allows us to represent interspecies interactions as an explicit function of environmental variables (such as substrate concentrations) by combining growth kinetics and a generalized …

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Ectoparasites Of The Critically Endangered Green Sawfish Pristis Zijsron And Sympatric Elasmobranchs In Western Australia, Jack Ingelbrecht, Karissa O. Lear, Storm B. Martin, Alan J. Lymbery, Bradley M. Norman, Geoffrey A. Boxshall, David L. Morgan Apr 2024

Ectoparasites Of The Critically Endangered Green Sawfish Pristis Zijsron And Sympatric Elasmobranchs In Western Australia, Jack Ingelbrecht, Karissa O. Lear, Storm B. Martin, Alan J. Lymbery, Bradley M. Norman, Geoffrey A. Boxshall, David L. Morgan

Harold W. Manter Laboratory of Parasitology: Library Materials

This study reports the metazoan ectoparasite fauna of juvenile Critically Endangered green sawfish, Pristis zijsron, and sympatric elasmobranchs in Western Australia. Five parasite taxa were found on 76 screened P. zijsron: Caligus furcisetifer (Copepoda: Caligidae), Dermopristis pterophila (Monogenea: Microbothriidae), Branchellion plicobranchus and Stibarobdella macrothela (Hirudinea: Piscicolidae), and praniza larvae of an unidentified gnathiid isopod. Only C. furcisetifer and D. pterophila were common, exhibiting discrepant site-specificity, with C. furcisetifer occurring mostly on the head and rostrum, and D. pterophila around the pectoral and pelvic fins. Intensity of infection for C. furcisetifer and D. pterophila increased with host total length and …

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Affect Variability And Cortisol In Context: The Moderating Roles Of Mean Affect And Stress, Brooke N. Jenkins, Logan T. Martin, Hee Youn (Helen) Lee, John F. Hunter, Amanda M. Acevedo, Sarah D. Pressman Apr 2024

Affect Variability And Cortisol In Context: The Moderating Roles Of Mean Affect And Stress, Brooke N. Jenkins, Logan T. Martin, Hee Youn (Helen) Lee, John F. Hunter, Amanda M. Acevedo, Sarah D. Pressman

Psychology Faculty Articles and Research

Positive and negative affect have been shown to have implications for hormones like cortisol but how moment to moment changes in affect (i.e., affect variability) influence cortisol secretion is less well understood. Additionally, context characteristics such as mean affect and stress may influence the association between affect variability and cortisol output. In the current study, we examined affect, stress, and cortisol data from 113 participants (age range = 25–63, M = 35.63, SD = 11.34; 29 % male; 42 % White/Caucasian, 37 % Asian or Pacific Islander, 13 % Hispanic/Latino, 4 % Black/African American, 1 % Native American, Eskimo, or …

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5-Ht Neurons Integrate Gaba And Dopamine Inputs To Regulate Meal Initiation, Kristine M Conde, Hueyzhong Wong, Shuzheng Fang, Yongxiang Li, Meng Yu, Yue Deng, Qingzhuo Liu, Xing Fang, Mengjie Wang, Yuhan Shi, Olivia Z Ginnard, Yuxue Yang, Longlong Tu, Hesong Liu, Hailan Liu, Na Yin, Jonathan C Bean, Junying Han, Megan E Burt, Sanika V Jossy, Yongjie Yang, Qingchun Tong, Benjamin R Arenkiel, Chunmei Wang, Yang He, Yong Xu Apr 2024

5-Ht Neurons Integrate Gaba And Dopamine Inputs To Regulate Meal Initiation, Kristine M Conde, Hueyzhong Wong, Shuzheng Fang, Yongxiang Li, Meng Yu, Yue Deng, Qingzhuo Liu, Xing Fang, Mengjie Wang, Yuhan Shi, Olivia Z Ginnard, Yuxue Yang, Longlong Tu, Hesong Liu, Hailan Liu, Na Yin, Jonathan C Bean, Junying Han, Megan E Burt, Sanika V Jossy, Yongjie Yang, Qingchun Tong, Benjamin R Arenkiel, Chunmei Wang, Yang He, Yong Xu

Children’s Nutrition Research Center Staff Publications

Obesity is a growing global health epidemic with limited effective therapeutics. Serotonin (5-HT) is one major neurotransmitter which remains an excellent target for new weight-loss therapies, but there remains a gap in knowledge on the mechanisms involved in 5-HT produced in the dorsal Raphe nucleus (DRN) and its involvement in meal initiation. Using a closed-loop optogenetic feeding paradigm, we showed that the 5-HTDRN→arcuate nucleus (ARH) circuit plays an important role in regulating meal initiation. Incorporating electrophysiology and ChannelRhodopsin-2-Assisted Circuit Mapping, we demonstrated that 5-HTDRN neurons receive inhibitory input partially from GABAergic neurons in the DRN, and the 5-HT response to …

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Contractile Vacuoles: A Rapidly Expanding (And Occasionally Diminishing?) Understanding, Kiran J. More, Harpreet Kaur, Alastair G.B. Simpson, Frederick W. Spiegel, Joel B. Dacks Apr 2024

Contractile Vacuoles: A Rapidly Expanding (And Occasionally Diminishing?) Understanding, Kiran J. More, Harpreet Kaur, Alastair G.B. Simpson, Frederick W. Spiegel, Joel B. Dacks

Biological Sciences Faculty Publications and Presentations

Osmoregulation is the homeostatic mechanism essential for the survival of organisms in hypoosmotic and hyperosmotic conditions. In freshwater or soil dwelling protists this is frequently achieved through the action of an osmoregulatory organelle, the contractile vacuole. This endomembrane organelle responds to the osmotic challenges and compensates by collecting and expelling the excess water to maintain the cellular osmolarity. As compared with other endomembrane organelles, this organelle is underappreciated and under-studied. Here we review the reported presence or absence of contractile vacuoles across eukaryotic diversity, as well as the observed variability in the structure, function, and molecular machinery of …

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Cybersecurity Skills, Knowledge And Abilities For Criminal Justice Professionals: An Exploratory Study Of Practitioners' Perspectives, Kate Quintana, Caroline Sutton Chubb, Daniel Olson, Anna Kosloski Apr 2024

Cybersecurity Skills, Knowledge And Abilities For Criminal Justice Professionals: An Exploratory Study Of Practitioners' Perspectives, Kate Quintana, Caroline Sutton Chubb, Daniel Olson, Anna Kosloski

Journal of Cybersecurity Education, Research and Practice

Cybersecurity has become increasingly important not only in the technology sector but in criminal justice professions as well, and significant challenges have arisen as a result. However, these challenges are not well discussed in the literature. To address this gap, and to study the cybersecurity trends impacting criminal justice professionals and the skills, knowledge and abilities criminal justice students need to succeed upon graduation, this research focuses on the role cybersecurity plays in the jobs that compose the main components of the criminal justice system and adjacent areas: law enforcement, the judicial process, corrections, social work, and military. This research …

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Biosensor-Enhanced Organ-On-A-Chip Models For Investigating Glioblastoma Tumor Microenvironment Dynamics, Gayathree Thenuwara, Bilal Javed, Baljit Singh, Furong Tian Apr 2024

Biosensor-Enhanced Organ-On-A-Chip Models For Investigating Glioblastoma Tumor Microenvironment Dynamics, Gayathree Thenuwara, Bilal Javed, Baljit Singh, Furong Tian

Articles

Glioblastoma, an aggressive primary brain tumor, poses a significant challenge owing to its dynamic and intricate tumor microenvironment. This review investigates the innovative integration of biosensor-enhanced organ-on-a-chip (OOC) models as a novel strategy for an in-depth exploration of glioblastoma tumor microenvironment dynamics. In recent years, the transformative approach of incorporating biosensors into OOC platforms has enabled real-time monitoring and analysis of cellular behaviors within a controlled microenvironment. Conventional in vitro and in vivo models exhibit inherent limitations in accurately replicating the complex nature of glioblastoma progression. This review addresses the existing research gap by pioneering the integration of biosensor-enhanced OOC …

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Cytokine Activity Estimation And Receptor Abundance Approximation With Multimodal Scrna-Seq/Cite-Seq Data., Azka Javaid Apr 2024

Cytokine Activity Estimation And Receptor Abundance Approximation With Multimodal Scrna-Seq/Cite-Seq Data., Azka Javaid

Dartmouth College Ph.D Dissertations

Single-cell RNA-sequencing (scRNA-seq) data enables individual cell resolution quantification of messenger RNA. While revolutionary for revealing key cell type and cell phenotype-specific heterogeneity, scRNA-seq data has important statistical challenges. First, scRNA-seq data is usually more sparse and second, it is more variable than bulk transcriptomics data. Given these challenges, more intuitive and interpretive statistical and computational methods are needed to develop appropriate solutions. Here, we detail the development of three techniques to perform receptor abundance estimation and cytokine activity estimation for scRNA-seq data. While SPECK (Surface Protein abundance Estimation using CKmeans-based clustered thresholding) and STREAK (gene Set Testing-based Receptor abundance …

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Nestedbd: Bayesian Inference Of Phylogenetic Trees From Single-Cell Copy Number Profiles Under A Birth-Death Model, Yushu Liu, Mohammadamin Edrisi, Zhi Yan, Huw A Ogilvie, Luay Nakhleh Apr 2024

Nestedbd: Bayesian Inference Of Phylogenetic Trees From Single-Cell Copy Number Profiles Under A Birth-Death Model, Yushu Liu, Mohammadamin Edrisi, Zhi Yan, Huw A Ogilvie, Luay Nakhleh

Faculty, Staff and Student Publications

Copy number aberrations (CNAs) are ubiquitous in many types of cancer. Inferring CNAs from cancer genomic data could help shed light on the initiation, progression, and potential treatment of cancer. While such data have traditionally been available via “bulk sequencing,” the more recently introduced techniques for single-cell DNA sequencing (scDNAseq) provide the type of data that makes CNA inference possible at the single-cell resolution. We introduce a new birth-death evolutionary model of CNAs and a Bayesian method, NestedBD, for the inference of evolutionary trees (topologies and branch lengths with relative mutation rates) from single-cell data. We evaluated NestedBD’s performance using …

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