Digital Commons Network^™

Correlation Between Molecular Prognostic Factors And Bevacizumab Therapeutic Resistance In Patients With Metastatic Colorectal Cancer; The Avamet Study, Adrian Paul Suceveanu, Dragos Serban, Andreea Daniela Caloian, Georgeta Camelia Cozaru, Anca Chisoi, Anca Antonela Nicolau, Ioan Sergiu Micu, Andra Iulia Suceveanu

Journal of Mind and Medical Sciences

Objectives. Colorectal cancer is responsible for more than two million cases diagnosed annually. Despite early diagnosis through screening programs and adequate treatment, 25% of cases are diagnosed with metastatic disease while up to 50% of patients diagnosed early progress to metastatic disease. Materials and Methods. The study of 40 patients aims to identify the role of placental growth factor and heparin-binding growth factor as prognostic tools for current treatments involving resistance to bevacizumab in metastatic colorectal cancer. Results. Our results suggested that overall survival was influenced by serum fibroblast growth factor 1 levels. A cut-off value of 260.71 pg/ml was …

Medical And Psychological Management Of Patients With A History Of Surgical Treatment For Pancreatic Diseases, Magdalena Țone, Daniel Cochior, Oana Denisa Balalau, Tomescu Dana Rodica, Cristian Balalau, Teodora Mocan, Aurelian Udristoiu, Gabriel Petre Gorecki

Journal of Mind and Medical Sciences

Background. Pancreatic cancer, known for its high mortality rate and late diagnosis, remains a significant health concern. Surgery offers a potential therapeutic remedy, but it is only valid in the early stage of detection. Increasing risk factors and an aging population are expected to raise the incidence of pancreatic cancer, further challenging healthcare systems. Methods. The general objective of this study was to analyze doctors' experiences regarding the health status of patients with benign pancreatic pathology who underwent surgery and were admitted to CF2 Clinical Hospital in Bucharest. The research involved a specialized questionnaire addressing various aspects of patient health, …

Preoperative Risk Factors In Hernia Recurrence: A Single-Center Study, Anca Tigora, Vlad Paic, Dragos Nicolae Garofil, Mircea Nicolae Bratucu, Mihai Zurzu, Daniela Nuta, Florian Popa, Valeriu Surlin, Stefan Patrascu, Victor Dan Eugen Strambu, Petru Adrian Radu

Journal of Mind and Medical Sciences

Background and Objectives. Hernia recurrence is still a great challenge for surgeons regarding the optimal surgical technique, the best alloplastic material and the management of risk factors (advanced age, female sex, body mass index, smoking, diabetes, the presence of connective tissue disorders, chronic cough, etc.). The present study attempts to assess the impact of these factors in hernia recurrence, as well as the integration of the prosthetic material at the tissue level, in order to reduce possible postoperative complications. Material and Methods. A retrospective study was performed on 108 patients operated (between January 2012 and December 2022) for recurrence of …

Low Anterior Rectal Resection; The Impact Of Anastomotic Fistula On Incidence And Severity Of Low Anterior Resection Syndrome, Georgiana Cotofana-Graure, Cecil Mirea, Silviu Daniel Preda, Stefan Patrascu, Tiberiu Stefanita Tenea-Cojan, Adina Turcu-Stiolica, Alexandru Munteanu, Vlad Padureanu, Dragos Margaritescu, Sandu Ramboiu, Dan Cartu, Valeriu Surlin, Petru Radu

Journal of Mind and Medical Sciences

Objectives. Low anterior resection is a common surgical procedure for rectal cancer, but it is associated with a distressing complication known as Low Anterior Resection Syndrome (LARS). The incidence of LARS varies, with severe symptoms persisting in some patients even years after surgery. This study aimed to investigate the association between anastomotic leak and LARS severity in rectal cancer patients. Methods. A retrospective analysis was conducted on 100 rectal cancer patients who underwent LAR between 2017 and 2021. Patients were categorized based on LARS questionnaire responses into groups with anastomotic leakage and LARS, LARS alone, or no LARS. Various factors, …

Assessing Mid To Long Term Amputation-Free Survival Rates In Chronic Limb-Threatening Ischemia; A Study Of Hybrid Vascular Techniques, Cristian Traian Paius, Vlad Denis Constantin, Alexandru Carap, Andrei Tarus, Grigore Tinica

Journal of Mind and Medical Sciences

Introduction. Chronic limb-threatening ischemia (CLTI) is a debilitating condition characterized by inadequate blood supply to the lower extremities, often leading to tissue damage, ulcers, and limb loss. Amputation-free survival (AFS) serves as a crucial measure in evaluating interventions and managing CLTI, emphasizing limb preservation, functional restoration, and prevention of recurrent ischemic events. Objectives. This study aimed to assess mid to long term AFS in CLTI patients treated with hybrid vascular techniques. Materials and Methods. Conducted over 24 months at the Emergency Hospital of Saint Pantelimon in Bucharest, Romania, the study enrolled 62 adult CLTI patients, tracking them postoperatively. Kaplan Meyer …

Prevalence, Persistence And Microscopic Aspects Of The Vomeronasal Organ In Normal Versus Embryos With Chromosomal Abnormalities, Carmen Constantina Martinescu, Marius Alexandru Moga, Codrut Ioan Ciurea, Lorena Dima, Liana Ples, Andreea Neculau

Journal of Mind and Medical Sciences

Background. The objective of this study was to describe the histological and immunohistochemical aspects of vomeronasal organ in two groups of (normal and pathological) embryos and fetuses, with chromosomal morphological abnormalities. Methods. The research was based on a retrospective, descriptive analysis, carried out over a period of 5 years. The study included 46 biopsy fragments taken from aborted embryos and fetuses aged between 9 and 23 weeks. We compared the microscopic structure of the vomeronasal organ using different histologic and immunohistochemical staining procedures. Results. Our results showed that in both groups of embryos and fetuses there are three major stages …

A New Approach To Balance Dental Fear And Anxiety By Using Bachtm Flower Therapy, Irina Maria Gheorghiu, Alexandru Andrei Iliescu, Stana Paunica, Marina Giurgiu, Brandusa Mocanu, George Alexandru Popescu, Anca Silvia Dumitriu

Journal of Mind and Medical Sciences

Treatments in dentistry currently consist of an interdisciplinary approach, including (but not necessarily limited to) the holistic perspective. The different fields of allopathic and complementary medicine are used together to ensure not only a high-quality restorative treatment, but also to provide patients with psychological and emotional support. This perspective also applies to dental anxiety, which consists of complex (emotional, vegetative and psychomotor) manifestations. One of the most well-known complementary therapies for reducing dental fear and anxiety is BachTM Flower Therapy. Even if the mechanism of action of this therapy is not yet scientifically documented, notable results have been and continue …

Genetic And Serological Markers In Colorectal Cancer Surgery, Adrian Silaghi, Vlad Denis Constantin, Dragos Serban, Dragos Epistatu, Ioana Paunica, Daniela Gabriela Bălan, Laura Florentina Rebegea

Journal of Mind and Medical Sciences

Colon cancer is relatively asymptomatic in the early stages, the manifestations appearing and intensifying with the evolution of the disease, especially when associated with local and/or systemic complications. In such cases, surgical interventions are often emergency and involve more extensive operations (on metabolically and immune-stressed organisms), so that an early diagnosis (endoscopy, tumor markers, etc.) remains not only desirable but even a priority, especially in predisposed patients (genetic factors, lifestyle, etc.). As a consequence, the involvement of tumor markers in colon neoplasms has become more and more investigated in recent times. This review investigates the roles of serological and genetic …

Effect Of Continuous Renal Replacement Therapy On Serum Levels Of Inflammatory Cytokines/Interleukin-17 In Severe Acute Pancreatitis, Diana Iosif, Adrian Paul Suceveanu, Marius Prazaru, Iulia Cindea, Viorel Gherghina, Anca Mihaela Pantea Stoian, Laura Mazilu, Dragos Serban, Alina Nicoara, Andra Iulia Suceveanu

Journal of Mind and Medical Sciences

Despite continuous investigations in the diagnosis and treatment of severe acute pancreatitis (SAP), this disease still remains a critical condition with a mortality rate of up to 35%. The pathophysiology of SAP involves an important inflammatory reaction of the pancreas (mediated by inflammatory cytokines and immune system activation), causing severe local tissue damage as well as important systemic imbalances. IL-17 is an inflammatory mediator that have a pivotal role in SAP evolution, generating multiple interactions between inflammatory cytokines and significantly influencing the immune system response. Consequently, continuous renal replacement therapy/CRRT was added to the conventional therapy, leading to improved treatment …

Diabetic Patients And Postoperative Complications In Colorectal Surgery, Ioana Paunica, Adrian Silaghi, Daniela Gabriela Bălan, Bogdan Socea, Cristian Balalau, Florin Silviu Groseanu, George Alexandru Popescu, Dragos Epistatu, Vlad Denis Constantin

Journal of Mind and Medical Sciences

Diabetes mellitus is one of the most common comorbidities of patients undergoing surgery. Colorectal surgery is frequently associated with postoperative complications, and diabetic patients represent a population that presents a high risk of developing such complications. Understanding the interrelationships between neoplastic disease and diabetes, as well as the pathophysiological mechanisms underlying postoperative complications, are essential for effective therapeutic management. Genetic predispositions, alterations in the gut microbiota, inflammatory response, ischemic, thrombotic and infectious processes contribute significantly to the development of severe surgical complications, such as anastomotic fistulas. Postoperative ileus, characterized by gastrointestinal dysmotility, is common in diabetic patients due to neuropathic …

The Role Of Psychogenic Factors In The Etiopathogenesis Of Autoimmune Disorders In The Oral Cavity, Nadya T. Avramova, Boyko K. Bonev

Journal of Mind and Medical Sciences

Autoimmune disorders (AD) represent a heterogeneous group of multifactorial chronic conditions, which are triggered secondary to the loss of self-antigen tolerance. Their etiology involves genetic, epigenetic, and environmental factors; however, AD cannot be explained by these factors alone. Recent studies have shown increasing stress levels in industrialized countries and also increasing trends in the prevalence of autoimmune diseases. The oral mucosa is extremely responsive to emotional influences such as stress, anxiety and depression. Therefore, oral diseases can appear as a direct expression of emotions or indirectly, due to various psychological mechanisms. The aim of this study is to find and …

Charting The History Of Social And Economic Analyses In The North-East Atlantic, Ospar, Region: Lessons Learned And Future Opportunities, Rob Van Der Veeren, Philip A.S. James, Maria G. Alarcon Blazquez, Xander Keijser

Journal of Ocean and Coastal Economics

Over the past decade, the North-East Atlantic region has witnessed a substantial increase in social and economic analyses related to ocean and coastal management. This article offers a comprehensive overview of this progress, focusing on the work of the International Cooperation Group - Economics and Social Analysis (ICG-ESA) within the OSPAR Commission. While highlighting ICG-ESA's contributions to the OSPAR Quality Status Report 2023, the paper underscores the necessity of integrating social analyses into OSPAR's decision-making processes. It calls for sustained efforts to prevent regression in the achieved progress, stressing the importance of accountability and collaboration among OSPAR and its contracting …

An Exploratory Comparison Of The Impact Of Covid-19 On American And Chinese College Student Lives, Arvind Agrawal, Alan Hamlin, Steve Barney, Yongchuan Shi

Mountain Plains Journal of Business and Technology

US and Chinese students in their home countries rated their life experiences since the advent of Covid-19 on various aspects of their lives, including academic performance, social life, and emotional, financial, and physical well-being. Input was also received about how Covid-19 has affected their communication, career planning, and post-graduate goals.

To assess the impacts of these changes on college students, the authors created a questionnaire to ask students about their perceptions of these COVID-related impacts on their personal lives. The survey had 56 questions, with 1580 students responding, providing both objective input and subjective comments. Due to the volume of …

Observational Analysis For Predicting Initial Spikes In Testing Volume Of Cohorts Inside And Outside Of A Regional Covid-19 Screening Program, Adam M. Franks, Seth Bergeron, Tammy Bannister, Justin Spradling, Tamara Lowe, Paris Johnson, Rajan Lamichhane, Stephen M. Petrany

Marshall Journal of Medicine

BACKGROUND Containing the highly contagious SARs-CoV-2 pathogen requires a safe and effective screening program. The aim of this observational cohort study is to analyze a regional testing center and identify factors predicting testing rates that direct supply and staffing needs.

METHODS A drive-through SAR-CoV-2 regional testing facility was created. Number of tests and positive results were collected for eighteen months. Data for testing demand was compared to positive results, percent positive rates (PPR), known external factors, and county PPR. Dissimilarities were contrasted with dynamic time warp and a detailed agreement analysis. The Grainger’s test was utilized to assess the degree …

Importance Of Mind-Body Medicine And Human Flourishing In The Training Of Physicians, Aviad Haramati

Marshall Journal of Medicine

No abstract provided.

Binding Interdependence: The Necessity Of Marriage In The Stonor Letters, Sarah Emmett

The Thetean: A Student Journal for Scholarly Historical Writing

Upon her Mattiage to William Stonor in 1475, Elizabeth Stonor, nee Croke, was no wedding amateur. Twice before, she had stood on the steps of the church, as was the custom, and promised to share her wealth and her body with her husband. Twice before, her husband had promised to provide for her and leave her a dower portion upon his death. Both grooms had offered Elizabeth gold and silver coins and a ring to seal their union, and both times, Elizabeth and her husband had prostrated themselves before the altar of the church and heard mass among their family, …

International Implications On Rising Sea Levels And Changing Ofmaritime Borders, Claire O'Brien, Megan Schumm

Ohio Northern University International Law Journal

No abstract provided.

Bad For The Gander: New Zealand’S Failure To Learn From Thecautionary Tales Of Unreliable Forensic-Science Evidence Andwrongful Convictions Abroad, Carrie Leonetti

Ohio Northern University International Law Journal

No abstract provided.

Educating For Equality: A Symposium On Combating Anti-Lgbtq+ Legislation: A Roundtable Discussion

Tennessee Journal of Race, Gender, & Social Justice

No abstract provided.

Editor's Note

Articulāte

No abstract provided.

A Comparative Analysis Of Field Electron Emission From Carbon Black Embedded Within Insulated Copper Hollowed Wires And Glass Tubes, Hatem A. Al-Braikat, Ahmad M D Jaber, Adel M. Abuamr, Mazen A. Madanat, Aseel A. Al-Jbarart, M-Ali H. Al-Akhras, Marwan S. Mousa

Karbala International Journal of Modern Science

In this study, two different methods are used to investigate carbon black as a cold field electron emitter. The first method is to incorporate carbon black into a specially designed insulated copper hollowed wire. The wire has a cup-shaped structure created by electrochemical etching. The second method involves the incorporation of carbon black into narrow glass tubes. A Comparative analyses is carried out to evaluate the effectiveness of each method. To evaluate the performance of the samples, the current-voltage characteristics will be examined using field electron microscopes. This analysis will provide an understanding of the emission of the carbon black …

Philosophy In Science: Can Philosophers Of Science Permeate Through Science And Produce Scientific Knowledge?, Thomas Pradeu, Maël Lemoine, Mahdi Khelfaoui, Yves Gingras

Presidential Fellows Articles and Research

Most philosophers of science do philosophy ‘on’ science. By contrast, others do philosophy ‘in’ science (PinS), that is, they use philosophical tools to address scientific problems and to provide scientifically useful proposals. Here, we consider the evidence in favour of a trend of this nature. We proceed in two stages. First, we identify relevant authors and articles empirically with bibliometric tools, given that PinS would be likely to infiltrate science and thus to be published in scientific journals (‘intervention’), cited in scientific journals (‘visibility’), and sometimes recognized as a scientific result by scientists (‘contribution’). We show that many central figures …

A Combination Of Generated Hydrogen Sulfide And Nitric Oxide Activity Has A Potentiated Protectant Effect Against Cisplatin Induced Nephrotoxicity, Faria Khurshid, Javeid Iqbal, Fiaz Ud Din Ahmad, Arslan Hussain Lodhi, Abdul Malik, Suhail Akhtar, Azmat Ali Khan, Marvi Imam Bux, Mohammed Younis

Biomedical Sciences Faculty Publications

Aim: Hydrogen sulfide and nitricoxide possess cytoprotective activity and in vivo, they are generated from exogenous sodium hydrosulfide and L-arginine respectively. Cisplatin is a major chemotherapeutic agent used to treat cancer and has a high incidence of nephrotoxicity as a side effect. The study aim was to explore the effects of NaHS and L-arginine or their combination on cisplatin induced nephrotoxicity in rats. Methods: Wistar Kyoto rats were given a single intraperitoneal dose of cisplatin (5 mg/kg) followed either by NaHS (56 μmol/kg, i. p.), L-arginine (1.25 g/L in drinking water) or their combination daily for 28-days. Post-mortem plasma, urine …

Chanticleer | April 2024, Jacksonville State University

Chanticleer

No abstract provided.

Learning Media Using Pop-Up Book “Variety Of Traditional Houses In Indonesia” As Alternative Media In Pancasila Education For Primary School, Nurul Hidayah Rofiah, Budiyono Budiyono, Rahmatika Dewi

Jurnal Civics: Media Kajian Kewarganegaraan

The research process involved creating a pop-up book for Pancasila Education, explicitly focusing on the physical diversity of traditional Indonesian houses. The study used the comprehensive ADDIE model for research and development, involving thorough analysis, design, development, implementation, and evaluation. Data collection techniques included qualitative and quantitative methods. The results showed that the pop-up books were of high quality, with media experts assessing them at 87.1, material experts at 83.3, learning experts at 73.3, and linguists at 81.7. Field-tested, the book received high scores from teachers and students at 98.0 and 93.3, respectively. The overall score was 91.0, indicating its …

Who Authors Social Science? Demographics And The Production Of Knowledge, Jeffrey W. Lockhart, Molly M. King, Christin Munsch

Sociology

Author demographics are of key epistemic importance in science—shaping the approaches to and contents of research—especially in social scientific knowledge production, yet we know very little about who produces social scientific publications. We fielded an original demographic survey of nearly 20,000 sociology, economics, and communication authors in the Web of Science from 2016–2020. Our results include not only details about gender and race/ethnicity but also the first descriptive statistics on social science authors’ sexuality, disability, parental education, and employment characteristics. We find authorship in the social sciences looks very different from other measures of disciplinary membership like who holds PhDs …

No Self: Consciousness, Life, And Value, Jiawei Ma

Philosophy Honors Projects

The problem of personal identity has been an ongoing debate in the history of philosophy for thousands of years. This thesis examines personal identity from a variety of philosophical approaches. I begin with the historical assumption made by Descartes and Locke that people have a 'self' because they have successive consciousness over time. I argue that no 'self' exists as a coherent entity because consciousness, which makes up the self, exists as separate pieces. By exploring the weakness of defining the self as consciousness, I argue that society is the efficient cause and final cause of personal identity. By studying …

The Indiana Statesman, April 30, 2024, Indiana State University

Student Newspaper

Godard confirmed new ISU president; Q&A with 500 festival princess; Columbia protesters given ultimatum; Emory University president apologizes

How And Why Foster Care Impacts Maltreated Youths' School Performance, Mallory Constantine

Lincy Institute Events

Youth mistreated within the foster care system are more likely to miss school as compared to non-maltreated peers. A single report of child maltreatment has a rapid and negative effect on school attendance and causes serious, long-term effects on school performance. A report of maltreatment substantiated by the department of family and child services removes a youth from a foster home and places the child in an alternative setting. These disruptions in foster care often result in additional problems with school behavior, achievement, and attendance. This lecture will explore how disruptions in foster care affect school behavior and performance and …

A Shift Of Inheritance Tradition In Batak Migrant Communities In Yogyakarta, Setiati Widihastuti, Iffah Nurhayati, Puji Wulandari Kuncorowati, Chandra Dewi Puspitasari

Jurnal Civics: Media Kajian Kewarganegaraan

This article examines the shift in customary inheritance in the Batak community that migrated to Yogyakarta. Traditionally, among the Batak people, the patrilineal system is a cultural heritage still preserved today. The enactment of the patrilineal system is one of the causes of the unequal position of Batak women's inheritance rights because only men have the right to become heirs. Interaction with people of different ethnicities, customs, and customs in overseas places not only expands the horizons of Batak nomads but also allows them to change their point of view so that leaving the roots of Batak customs will be …