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Family Accommodation In Children And Adolescents With Misophonia, Eric A Storch, Andrew G Guzick, Johann D'Souza, Jane Clinger, Daphne Ayton, Minjee Kook, Conor Rork, Eleanor E Smith, Isabel A Draper, Nasim Khalfe, Catherine E Rast, Nicholas Murphy, Marijn Lijfijjt, Wayne K Goodman, Matti Cervin May 2024

Family Accommodation In Children And Adolescents With Misophonia, Eric A Storch, Andrew G Guzick, Johann D'Souza, Jane Clinger, Daphne Ayton, Minjee Kook, Conor Rork, Eleanor E Smith, Isabel A Draper, Nasim Khalfe, Catherine E Rast, Nicholas Murphy, Marijn Lijfijjt, Wayne K Goodman, Matti Cervin

Center for Medical Ethics and Health Policy Staff Publications

Family accommodation (e.g., reassurance, modifying routines, assisting avoidance) has not been explored among youth with misophonia but may have important clinical and intervention implications. We examined family accommodation in 102 children and adolescents with interview-confirmed misophonia and compared its frequency and content to family accommodation in 95 children and adolescents with anxiety disorders. Findings showed that family accommodation was ubiquitous in pediatric misophonia and may be even more frequent than in youth with anxiety disorders. Assisting the child, participating in misophonia-related behaviors, and modifying family routines were endorsed by more than 70% of parents of children with misophonia. Further, compared …


Altered Myocardial Lipid Regulation In Junctophilin-2-Associated Familial Cardiomyopathies, Satadru K Lahiri, Feng Jin, Yue Zhou, Ann P Quick, Carlos F Kramm, Meng C Wang, Xander Ht Wehrens May 2024

Altered Myocardial Lipid Regulation In Junctophilin-2-Associated Familial Cardiomyopathies, Satadru K Lahiri, Feng Jin, Yue Zhou, Ann P Quick, Carlos F Kramm, Meng C Wang, Xander Ht Wehrens

Faculty, Staff and Students Publications

Myocardial lipid metabolism is critical to normal heart function, whereas altered lipid regulation has been linked to cardiac diseases including cardiomyopathies. Genetic variants in the JPH2 gene can cause hypertrophic cardiomyopathy (HCM) and, in some cases, dilated cardiomyopathy (DCM). In this study, we tested the hypothesis that JPH2 variants identified in patients with HCM and DCM, respectively, cause distinct alterations in myocardial lipid profiles. Echocardiography revealed clinically significant cardiac dysfunction in both knock-in mouse models of cardiomyopathy. Unbiased myocardial lipidomic analysis demonstrated significantly reduced levels of total unsaturated fatty acids, ceramides, and various phospholipids in both mice with HCM and …


A Biophysically Constrained Brain Connectivity Model Based On Stimulation-Evoked Potentials, William Schmid, Isabel A Danstrom, Maria Crespo Echevarria, Joshua Adkinson, Layth Mattar, Garrett P Banks, Sameer A Sheth, Andrew J Watrous, Sarah R Heilbronner, Kelly R Bijanki, Alessandro Alabastri, Eleonora Bartoli May 2024

A Biophysically Constrained Brain Connectivity Model Based On Stimulation-Evoked Potentials, William Schmid, Isabel A Danstrom, Maria Crespo Echevarria, Joshua Adkinson, Layth Mattar, Garrett P Banks, Sameer A Sheth, Andrew J Watrous, Sarah R Heilbronner, Kelly R Bijanki, Alessandro Alabastri, Eleonora Bartoli

Faculty, Staff and Students Publications

BACKGROUND: Single-pulse electrical stimulation (SPES) is an established technique used to map functional effective connectivity networks in treatment-refractory epilepsy patients undergoing intracranial-electroencephalography monitoring. While the connectivity path between stimulation and recording sites has been explored through the integration of structural connectivity, there are substantial gaps, such that new modeling approaches may advance our understanding of connectivity derived from SPES studies.

NEW METHOD: Using intracranial electrophysiology data recorded from a single patient undergoing stereo-electroencephalography (sEEG) evaluation, we employ an automated detection method to identify early response components, C1, from pulse-evoked potentials (PEPs) induced by SPES. C1 components were utilized for a …


Genome-Wide Analysis In Over 1 Million Individuals Of European Ancestry Yields Improved Polygenic Risk Scores For Blood Pressure Traits, Jacob M Keaton, Zoha Kamali, Tian Xie, Ahmad Vaez, Ariel Williams, Slavina B Goleva, Alireza Ani, Evangelos Evangelou, Jacklyn N Hellwege, Loic Yengo, William J Young, Matthew Traylor, Ayush Giri, Zhili Zheng, Jian Zeng, Daniel I Chasman, Andrew P Morris, Mark J Caulfield, Shih-Jen Hwang, Jaspal S Kooner, David Conen, John R Attia, Alanna C Morrison, Ruth J F Loos, Kati Kristiansson, Reinhold Schmidt, Andrew A Hicks, Peter P Pramstaller, Christopher P Nelson, Nilesh J Samani, Lorenz Risch, Ulf Gyllensten, Olle Melander, Harriette Riese, James F Wilson, Harry Campbell, Stephen S Rich, Bruce M Psaty, Yingchang Lu, Jerome I Rotter, Xiuqing Guo, Kenneth M Rice, Peter Vollenweider, Johan Sundström, Claudia Langenberg, Martin D Tobin, Vilmantas Giedraitis, Jian'an Luan, Jaakko Tuomilehto, Zoltan Kutalik, Samuli Ripatti, Veikko Salomaa, Giorgia Girotto, Stella Trompet, J Wouter Jukema, Pim Van Der Harst, Paul M Ridker, Franco Giulianini, Veronique Vitart, Anuj Goel, Hugh Watkins, Sarah E Harris, Ian J Deary, Peter J Van Der Most, Albertine J Oldehinkel, Bernard D Keavney, Caroline Hayward, Archie Campbell, Michael Boehnke, Laura J Scott, Thibaud Boutin, Chrysovalanto Mamasoula, Marjo-Riitta Järvelin, Annette Peters, Christian Gieger, Edward G Lakatta, Francesco Cucca, Jennie Hui, Paul Knekt, Stefan Enroth, Martin H De Borst, Ozren Polašek, Maria Pina Concas, Eulalia Catamo, Massimiliano Cocca, Ruifang Li-Gao, Edith Hofer, Helena Schmidt, Beatrice Spedicati, Melanie Waldenberger, David P Strachan, Maris Laan, Alexander Teumer, Marcus Dörr, Vilmundur Gudnason, James P Cook, Daniela Ruggiero, Ivana Kolcic, Eric Boerwinkle, Michela Traglia, Terho Lehtimäki, Olli T Raitakari, Andrew D Johnson, Christopher Newton-Cheh, Morris J Brown, Anna F Dominiczak, Peter J Sever, Neil Poulter, John C Chambers, Roberto Elosua, David Siscovick, Tõnu Esko, Andres Metspalu, Rona J Strawbridge, Markku Laakso, Anders Hamsten, Jouke-Jan Hottenga, Eco De Geus, Andrew D Morris, Colin N A Palmer, Ilja M Nolte, Yuri Milaneschi, Jonathan Marten, Alan Wright, Eleftheria Zeggini, Joanna M M Howson, Christopher J O'Donnell, Tim Spector, Mike A Nalls, Eleanor M Simonsick, Yongmei Liu, Cornelia M Van Duijn, Adam S Butterworth, John N Danesh, Cristina Menni, Nicholas J Wareham, Kay-Tee Khaw, Yan V Sun, Peter W F Wilson, Kelly Cho, Peter M Visscher, Joshua C Denny, Million Veteran Program, Lifelines Cohort Study, Charge Consortium, Icbp Consortium, Daniel Levy, Todd L Edwards, Patricia B Munroe, Harold Snieder, Helen R Warren May 2024

Genome-Wide Analysis In Over 1 Million Individuals Of European Ancestry Yields Improved Polygenic Risk Scores For Blood Pressure Traits, Jacob M Keaton, Zoha Kamali, Tian Xie, Ahmad Vaez, Ariel Williams, Slavina B Goleva, Alireza Ani, Evangelos Evangelou, Jacklyn N Hellwege, Loic Yengo, William J Young, Matthew Traylor, Ayush Giri, Zhili Zheng, Jian Zeng, Daniel I Chasman, Andrew P Morris, Mark J Caulfield, Shih-Jen Hwang, Jaspal S Kooner, David Conen, John R Attia, Alanna C Morrison, Ruth J F Loos, Kati Kristiansson, Reinhold Schmidt, Andrew A Hicks, Peter P Pramstaller, Christopher P Nelson, Nilesh J Samani, Lorenz Risch, Ulf Gyllensten, Olle Melander, Harriette Riese, James F Wilson, Harry Campbell, Stephen S Rich, Bruce M Psaty, Yingchang Lu, Jerome I Rotter, Xiuqing Guo, Kenneth M Rice, Peter Vollenweider, Johan Sundström, Claudia Langenberg, Martin D Tobin, Vilmantas Giedraitis, Jian'an Luan, Jaakko Tuomilehto, Zoltan Kutalik, Samuli Ripatti, Veikko Salomaa, Giorgia Girotto, Stella Trompet, J Wouter Jukema, Pim Van Der Harst, Paul M Ridker, Franco Giulianini, Veronique Vitart, Anuj Goel, Hugh Watkins, Sarah E Harris, Ian J Deary, Peter J Van Der Most, Albertine J Oldehinkel, Bernard D Keavney, Caroline Hayward, Archie Campbell, Michael Boehnke, Laura J Scott, Thibaud Boutin, Chrysovalanto Mamasoula, Marjo-Riitta Järvelin, Annette Peters, Christian Gieger, Edward G Lakatta, Francesco Cucca, Jennie Hui, Paul Knekt, Stefan Enroth, Martin H De Borst, Ozren Polašek, Maria Pina Concas, Eulalia Catamo, Massimiliano Cocca, Ruifang Li-Gao, Edith Hofer, Helena Schmidt, Beatrice Spedicati, Melanie Waldenberger, David P Strachan, Maris Laan, Alexander Teumer, Marcus Dörr, Vilmundur Gudnason, James P Cook, Daniela Ruggiero, Ivana Kolcic, Eric Boerwinkle, Michela Traglia, Terho Lehtimäki, Olli T Raitakari, Andrew D Johnson, Christopher Newton-Cheh, Morris J Brown, Anna F Dominiczak, Peter J Sever, Neil Poulter, John C Chambers, Roberto Elosua, David Siscovick, Tõnu Esko, Andres Metspalu, Rona J Strawbridge, Markku Laakso, Anders Hamsten, Jouke-Jan Hottenga, Eco De Geus, Andrew D Morris, Colin N A Palmer, Ilja M Nolte, Yuri Milaneschi, Jonathan Marten, Alan Wright, Eleftheria Zeggini, Joanna M M Howson, Christopher J O'Donnell, Tim Spector, Mike A Nalls, Eleanor M Simonsick, Yongmei Liu, Cornelia M Van Duijn, Adam S Butterworth, John N Danesh, Cristina Menni, Nicholas J Wareham, Kay-Tee Khaw, Yan V Sun, Peter W F Wilson, Kelly Cho, Peter M Visscher, Joshua C Denny, Million Veteran Program, Lifelines Cohort Study, Charge Consortium, Icbp Consortium, Daniel Levy, Todd L Edwards, Patricia B Munroe, Harold Snieder, Helen R Warren

Faculty, Staff and Student Publications

Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10-8) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences in BP (16.9 mmHg systolic BP, 95% CI, 15.5-18.2 mmHg, P = 2.22 × 10-126) and more than a sevenfold higher odds of hypertension risk (odds ratio, 7.33; 95% CI, 5.54-9.70; P = 4.13 × 10-44) in an independent dataset. Adding PRS into hypertension-prediction models increased the area under the receiver operating characteristic curve (AUROC) from 0.791 (95% CI, 0.781-0.801) to 0.826 (95% CI, 0.817-0.836, ∆AUROC, 0.035, P = 1.98 × 10-34). We compare the 2,103 loci results in non-European ancestries and show significant PRS associations in a large African-American sample. Secondary analyses implicate 500 genes previously unreported for BP. Our study highlights the role of increasingly large genomic studies for precision health research.


Age-Related Differences In The Mouse Corneal Epithelial Transcriptome And Their Impact On Corneal Wound Healing, Anmar Abu-Romman, Kaitlin K Scholand, Gowthaman Govindarajan, Zhiyuan Yu, Sonali Pal-Ghosh, Mary A Stepp, Cintia S De Paiva May 2024

Age-Related Differences In The Mouse Corneal Epithelial Transcriptome And Their Impact On Corneal Wound Healing, Anmar Abu-Romman, Kaitlin K Scholand, Gowthaman Govindarajan, Zhiyuan Yu, Sonali Pal-Ghosh, Mary A Stepp, Cintia S De Paiva

Faculty, Staff and Students Publications

PURPOSE: Aging is a risk factor for dry eye. We sought to identify changes in the aged mouse corneal epithelial transcriptome and determine how age affects corneal sensitivity, re-epithelialization, and barrier reformation after corneal debridement.

METHODS: Corneal epithelium of female C57BL/6J (B6) mice of different ages (2, 12, 18, and 24 months) was collected, RNA extracted, and bulk RNA sequencing performed. Cornea sensitivity was measured with an esthesiometer in 2- to 3-month-old, 12- to 13-month-old, 18- to 19-month-old, and 22- to 25-month-old female and male mice. The 2-month-old and 18-month-old female and male mice underwent unilateral corneal debridement using a …


Application Of Microphytes For Soil Reclamation, Lalit Saini, Hina Upadhyay, Arindam Chakraborty May 2024

Application Of Microphytes For Soil Reclamation, Lalit Saini, Hina Upadhyay, Arindam Chakraborty

Research Publications (2021 to 2025)

Microphytes incorporate several characteristics that are becoming increasingly important in a complex farming setting and the process of land reclamation. Microalgae/microphytes boost soil productivity and structure by adding minerals and improving microbial soil quality metrics and nutrient cycling. Protecting plants from disease, producing phytohormones and other bioactive compounds, and associating with plant roots are the ways through which microalgae contribute to plant development. These results are significant as they could lead to further advancements in the discovery of substances that can boost growth or the development of crops that do not need nitrogen. Microalgae have massive untapped capabilities as natural …


Exopolysaccharides Of Lactic Acid Bacteria Isolated From Labneh: Characterization, Bioactivities, And Effects On Gut Microbiome And Fermented Milk Rheology, Mohammed Tarique May 2024

Exopolysaccharides Of Lactic Acid Bacteria Isolated From Labneh: Characterization, Bioactivities, And Effects On Gut Microbiome And Fermented Milk Rheology, Mohammed Tarique

Dissertations

Exopolysaccharides (EPS), produced by Lactic Acid Bacteria (LAB), are carbohydrate polymers with unique physicochemical properties and various biological activities widely used in food and pharmaceutical industries. This dissertation is aimed to (1) screen 42 new isolates from traditional yogurt-like products (Labneh) for their probiotic nature and identify the LAB strains using 16S rDNA sequencing; (2) optimize the conditions like pH, temperature, time, and quantity of sucrose for the growth of EPS produced by four selected LAB isolates; (3) purify and characterize EPS for the contents and investigate the bioactivities of the partially purified EPS; (4) study the effects of the …


Phenolic Compounds In Date Fruits (Phoenix Dactylifera L.), Muneeba Zubair Alam May 2024

Phenolic Compounds In Date Fruits (Phoenix Dactylifera L.), Muneeba Zubair Alam

Dissertations

This study investigated the phenolic compounds in date fruits, mainly soluble and hydrolyzable compounds, and insoluble melanin. Soluble (27.5–54.0 mg/100 g FW) and hydrolyzable (24.0–78.5 mg/100g FW) phenolic compounds were determined in 18 cultivars using ultra-performance liquid chromatography coupled with mass spectrometry. Phenolic acids were predominant in both fractions while flavonoids were mainly present in the soluble phenolic fraction and the proanthocyanidin B1 and B2 were only present in the hydrolyzable fraction. Four total antioxidant activity assays (total phenolic content, ABTS, FRAP, and DPPH) gave different results for both the soluble and hydrolysable fractions of 26 date fruit cultivars, which …


Valorization Of Date Palm Waste For The Isolation, Characterization, And Surface Chemistry Modification Of Nanocellulose, Mohsin Raza May 2024

Valorization Of Date Palm Waste For The Isolation, Characterization, And Surface Chemistry Modification Of Nanocellulose, Mohsin Raza

Dissertations

This dissertation focuses on the utilization of date palm waste, a lignocellulosic material, as a source for the extraction of nanocellulose (NC), a versatile biopolymer with applications in biodegradable composites, bioplastics, and food packaging. Conventional methods of NC production using mineral acids such as sulphuric and hydrochloric acid are reaching their limits of toxicity, so more environmentally friendly alternatives such as ionic liquids (ILs) are being explored. The research focuses on the characterization of different date palm wastes to evaluate their α−cellulose content, lignocellulosic character, and thermal stability. By comparing extraction methods with mineral acids and ILs, the study evaluates …


Sharp Injuries And Splash Exposures Among Healthcare Workers In The United Arab Emirates, Ibtisam Aref Karkaz May 2024

Sharp Injuries And Splash Exposures Among Healthcare Workers In The United Arab Emirates, Ibtisam Aref Karkaz

Dissertations

Brief introduction: Occupational injuries, including sharps injuries and splash exposures, pose significant risks to healthcare workers worldwide. These incidents can lead to the transmission of bloodborne infections, resulting in substantial healthcare costs and workforce challenges. Aims: The present study aimed at investigating sharps injuries and splash exposures among healthcare workers in Abu Dhabi government hospitals. To achieve the aim, the study planned to determine the frequency of sharps injuries and splash exposures, and to identify their risk factors, applied preventive measures, and consequent occupational infections. Method: Secondary data from the available records of all sharp injuries and splash exposures reported …


The Role Of Abu Dhabi's Nearshore Marine Environments In The Ecology Of Elasmobranch Fishes, Stephan Bruns May 2024

The Role Of Abu Dhabi's Nearshore Marine Environments In The Ecology Of Elasmobranch Fishes, Stephan Bruns

Dissertations

This dissertation investigated the role of inshore habitats in the ecology of elasmobranch fishes, with a specific focus on the wider Khor Fardiah Region on the eastern site of Abu Dhabi City. Once the vulnerability of these environments to anthropogenic pressure and climate change is recognised, it is clear that nearshore environments are susceptible to adverse outcomes. Hence, this dissertation aims to provide informative data that can help in devising effective conservation strategies. The study used a multi-survey technique approach, including stereo-BRUVS, acoustic telemetry, and satellite tracking, in combination with local ecological knowledge to explore the species diversity and habitat …


Australian Non-Perennial Rivers: Global Lessons And Research Opportunities, Margaret Shanafield, Melanie Blanchette, Edoardo Daly, Naomi Wells, Ryan M. Burrows, Kathryn Korbel, Gabriel C. Rau, Sarah Bourke, Gresley Wakelin-King, Aleicia Holland, Timothy Ralph, Gavan Mcgrath, Belinda Robson, Keirnan Fowler, Martin S. Andersen, Songyan Yu, Christopher S. Jones, Nathan Waltham, Eddie W. Banks, Alissa Flatley, Catherine Leigh, Sally Maxwell, Andre Siebers, Nick Bond, Leah Beesley, Grant Hose, Jordan Iles, Ian Cartwright, Michael Reid, Thiaggo De Castro Tayer, Clément Duvert May 2024

Australian Non-Perennial Rivers: Global Lessons And Research Opportunities, Margaret Shanafield, Melanie Blanchette, Edoardo Daly, Naomi Wells, Ryan M. Burrows, Kathryn Korbel, Gabriel C. Rau, Sarah Bourke, Gresley Wakelin-King, Aleicia Holland, Timothy Ralph, Gavan Mcgrath, Belinda Robson, Keirnan Fowler, Martin S. Andersen, Songyan Yu, Christopher S. Jones, Nathan Waltham, Eddie W. Banks, Alissa Flatley, Catherine Leigh, Sally Maxwell, Andre Siebers, Nick Bond, Leah Beesley, Grant Hose, Jordan Iles, Ian Cartwright, Michael Reid, Thiaggo De Castro Tayer, Clément Duvert

Research outputs 2022 to 2026

Non-perennial rivers are valuable water resources that support millions of humans globally, as well as unique riparian ecosystems. In Australia, the Earth's driest inhabited continent, over 70% of rivers are non-perennial due to a combination of ancient landscape, dry climates, highly variable rainfall regimes, and human interventions that have altered riverine environments. Here, we review Australian non-perennial river research incorporating geomorphology, hydrology, biogeochemistry, ecology, and Indigenous knowledges. The dominant research themes in Australia were drought, floods, salinity, dryland ecology, and water management. Future research will likely follow these themes but must address emerging threats to river systems due to climate …


Ublade: Efficient Batch Processing For Uncertainty Graph Queries, Siyuan Yao, Yuchen Li, Shixuan Sun, Jiaxin Jiang, Bingsheng He May 2024

Ublade: Efficient Batch Processing For Uncertainty Graph Queries, Siyuan Yao, Yuchen Li, Shixuan Sun, Jiaxin Jiang, Bingsheng He

Research Collection School Of Computing and Information Systems

The study of uncertain graphs is crucial in diverse fields, including but not limited to protein interaction analysis, viral marketing, and network reliability. Processing queries on uncertain graphs presents formidable challenges due to the vast probabilistic space they encapsulate. While existing systems employ batch processing to address these challenges, their performance is often compromised by the suboptimal selection of parallel graph traversal methods, the excessive costs in random number generation, and additional sampling-loads intrinsic to batch processing. In this paper, we introduce uBlade, an efficient batch-processing framework for uncertain graph queries on multi-core CPUs. uBlade utilizes the work-efficient graph traversal, …


Vascular Brain Digital Twins For Medical Training And Education In Metaverse, Shamma Khaled Alghafri May 2024

Vascular Brain Digital Twins For Medical Training And Education In Metaverse, Shamma Khaled Alghafri

Theses

This study addresses the need for innovative educational tools in the field of anatomy, specifically focusing on brain anatomy. The objective is to develop a virtual reality application and a 3D visualization that offer immersive and interactive learning experiences for students. The VR application, developed using Unity and designed for the Oculus Quest 2 headset, creates an immersive virtual laboratory environment. This environment includes interactive elements such as a table with buttons for displaying brain models and a whiteboard for user interaction. Users can manipulate and explore different brain structures, enhancing their understanding of complex anatomical features. Additionally, we integrated …


Quantum Machine Learning For Credit Scoring, Nikolaos Schetakis, Davit Aghamalyan, Micheael Boguslavsky, Agnieszka Rees, Marc Rakotomalala, Paul Robert Griffin May 2024

Quantum Machine Learning For Credit Scoring, Nikolaos Schetakis, Davit Aghamalyan, Micheael Boguslavsky, Agnieszka Rees, Marc Rakotomalala, Paul Robert Griffin

Research Collection School Of Computing and Information Systems

This study investigates the integration of quantum circuits with classical neural networks for enhancing credit scoring for small- and medium-sized enterprises (SMEs). We introduce a hybrid quantum–classical model, focusing on the synergy between quantum and classical rather than comparing the performance of separate quantum and classical models. Our model incorporates a quantum layer into a traditional neural network, achieving notable reductions in training time. We apply this innovative framework to a binary classification task with a proprietary real-world classical credit default dataset for SMEs in Singapore. The results indicate that our hybrid model achieves efficient training, requiring significantly fewer epochs …


Antioxidant Activities And Protective Effects Of Shorea Macrophylla Leaf And Bark Extracts, Salfarina Ramli, Nik Nor Sabrina Sukri, Nur Adhwa’ Faqihah Zulkifli, Donna Maretta Ariestanti, Chee Yan Choo, Hasseri Halim, Nurhuda Manshoor, Richard Johari James May 2024

Antioxidant Activities And Protective Effects Of Shorea Macrophylla Leaf And Bark Extracts, Salfarina Ramli, Nik Nor Sabrina Sukri, Nur Adhwa’ Faqihah Zulkifli, Donna Maretta Ariestanti, Chee Yan Choo, Hasseri Halim, Nurhuda Manshoor, Richard Johari James

Pharmaceutical Sciences and Research

Shorea macrophylla, also known as the ‘Engkabang’ tree or Light Red Meranti, is renowned for its role in reforestation efforts. Despite lacking records of traditional use, the reported biological activities of other species within the Shorea genus spark curiosity about the potential biological activities of this plant. Therefore, this study aims to explore the antioxidant capabilities of S. macrophylla leaf and bark extracts, along with their protective effects against oxidative stress using a brine shrimp model. In the evaluation of antioxidant potential, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays were employed. Extracts were incubated in …


A Computational Investigation Into Thermo-Kinetic Parameters Governing The Decomposition Of Bio-Oil Model Compounds, Ali Huseein Aljefri May 2024

A Computational Investigation Into Thermo-Kinetic Parameters Governing The Decomposition Of Bio-Oil Model Compounds, Ali Huseein Aljefri

Theses

Among notable products from thermal degradation of biomass are simple oxygen-containing aromatics. These compounds typically appear in high loads in collected bio-oil derived from biomass. As such, it is important to comprehend the decomposition chemistry of this category of compounds. This thesis takes on board a general approach to report thermo-kinetic parameters that govern decomposition of a selected set of bio-oil model compounds in two distinct systems: firstly radical-derived pathways in the gas phase and secondly thermal degradation in their condensed media. The first is attained through accurate density functional calculations while the second is accomplished through the use of …


Vibmilk: Non-Intrusive Milk Spoilage Detection Via Smartphone Vibration, Yuezhong Wu, Wei Song, Yanxiang Wang, Dong Ma, Weitao Xu, Mahbub Hassan, Wen Hu May 2024

Vibmilk: Non-Intrusive Milk Spoilage Detection Via Smartphone Vibration, Yuezhong Wu, Wei Song, Yanxiang Wang, Dong Ma, Weitao Xu, Mahbub Hassan, Wen Hu

Research Collection School Of Computing and Information Systems

Quantifying the chemical process of milk spoilage is challenging due to the need for bulky, expensive equipment that is not user-friendly for milk producers or customers. This lack of a convenient and accurate milk spoilage detection system can cause two significant issues. First, people who consume spoiled milk may experience serious health problems. Secondly, milk manufacturers typically provide a “best before” date to indicate freshness, but this date only shows the highest quality of the milk, not the last day it can be safely consumed, leading to significant milk waste. A practical and efficient solution to this problem is proposed …


Vaid: Indexing View Designs In Visual Analytics System, Lu Ying, Aoyu Wu, Haotian Li, Zikun Deng, Ji Lan, Jiang Wu, Yong Wang, Huamin Qu, Dazhen Deng, Yingcai Wu May 2024

Vaid: Indexing View Designs In Visual Analytics System, Lu Ying, Aoyu Wu, Haotian Li, Zikun Deng, Ji Lan, Jiang Wu, Yong Wang, Huamin Qu, Dazhen Deng, Yingcai Wu

Research Collection School Of Computing and Information Systems

Visual analytics (VA) systems have been widely used in various application domains. However, VA systems are complex in design, which imposes a serious problem: although the academic community constantly designs and implements new designs, the designs are difficult to query, understand, and refer to by subsequent designers. To mark a major step forward in tackling this problem, we index VA designs in an expressive and accessible way, transforming the designs into a structured format. We first conducted a workshop study with VA designers to learn user requirements for understanding and retrieving professional designs in VA systems. Thereafter, we came up …


Automatic Grading Of Short Answers Using Large Language Models In Software Engineering Courses, Nguyen Binh Duong Ta, Yi Meng Chai May 2024

Automatic Grading Of Short Answers Using Large Language Models In Software Engineering Courses, Nguyen Binh Duong Ta, Yi Meng Chai

Research Collection School Of Computing and Information Systems

Short-answer based questions have been used widely due to their effectiveness in assessing whether the desired learning outcomes have been attained by students. However, due to their open-ended nature, many different answers could be considered entirely or partially correct for the same question. In the context of computer science and software engineering courses where the enrolment has been increasing recently, manual grading of short-answer questions is a time-consuming and tedious process for instructors. In software engineering courses, assessments concern not just coding but many other aspects of software development such as system analysis, architecture design, software processes and operation methodologies …


Unraveling The ‘Anomaly’ In Time Series Anomaly Detection: A Self-Supervised Tri-Domain Solution, Yuting Sun, Guansong Pang, Guanhua Ye, Tong Chen, Xia Hu, Hongzhi Yin May 2024

Unraveling The ‘Anomaly’ In Time Series Anomaly Detection: A Self-Supervised Tri-Domain Solution, Yuting Sun, Guansong Pang, Guanhua Ye, Tong Chen, Xia Hu, Hongzhi Yin

Research Collection School Of Computing and Information Systems

The ongoing challenges in time series anomaly detection (TSAD), including the scarcity of anomaly labels and the variability in anomaly lengths and shapes, have led to the need for a more robust and efficient solution. As limited anomaly labels hinder traditional supervised models in anomaly detection, various state-of-the-art (SOTA) deep learning (DL) techniques (e.g., self-supervised learning) are introduced to tackle this issue. However, they encounter difficulties handling variations in anomaly lengths and shapes, limiting their adaptability to diverse anomalies. Additionally, many benchmark datasets suffer from the problem of having explicit anomalies that even random functions can detect. This problem is …


Anomalyclip: Object-Agnostic Prompt Learning For Zero-Shot Anomaly Detection, Qihang Zhou, Guansong Pang, Yu Tian, Shibo He, Jiming Chen May 2024

Anomalyclip: Object-Agnostic Prompt Learning For Zero-Shot Anomaly Detection, Qihang Zhou, Guansong Pang, Yu Tian, Shibo He, Jiming Chen

Research Collection School Of Computing and Information Systems

Zero-shot anomaly detection (ZSAD) requires detection models trained using auxiliary data to detect anomalies without any training sample in a target dataset. It is a crucial task when training data is not accessible due to various concerns, e.g., data privacy, yet it is challenging since the models need to generalize to anomalies across different domains where the appearance of foreground objects, abnormal regions, and background features, such as defects/tumors on different products/ organs, can vary significantly. Recently large pre-trained vision-language models (VLMs), such as CLIP, have demonstrated strong zero-shot recognition ability in various vision tasks, including anomaly detection. However, their …


3d Bioprinting Techniques As A Valuable Toolbox For Design Of Advanced Cancer Models, Daniel Ramos Apr 2024

3d Bioprinting Techniques As A Valuable Toolbox For Design Of Advanced Cancer Models, Daniel Ramos

McNair Research Journal SJSU

No abstract provided.


Insulin Signal Transduction Mediates Ethanol-Induced Feeding Dysfunction In A Fly Model Of Fetal Alcohol Spectrum Disorder, Manae Matsubara Apr 2024

Insulin Signal Transduction Mediates Ethanol-Induced Feeding Dysfunction In A Fly Model Of Fetal Alcohol Spectrum Disorder, Manae Matsubara

McNair Research Journal SJSU

No abstract provided.


Finding Ways To Transform A College Going Culture And Aspirations Of Latinx Students, Martin Macias Apr 2024

Finding Ways To Transform A College Going Culture And Aspirations Of Latinx Students, Martin Macias

McNair Research Journal SJSU

No abstract provided.


Misgendering As A Microaggression: Gender Expression And Trans Pedagogy, Mylene Gibbs Apr 2024

Misgendering As A Microaggression: Gender Expression And Trans Pedagogy, Mylene Gibbs

McNair Research Journal SJSU

No abstract provided.


Front Matter, Maria Cruz Apr 2024

Front Matter, Maria Cruz

McNair Research Journal SJSU

No abstract provided.


Full Issue Apr 2024

Full Issue

McNair Research Journal SJSU

No abstract provided.


Metachronous Mucinous Breast Carcinoma And Mucinous Pancreatic Cystadenoma In A Patient With Metabolic Comorbidities; Case Report And A Literature Review, Teodora Gabriela Alexescu, Irina Obada, Angela Cozma, Mirela Georgiana Perne, Olga Hilda Orasan, Vasile Negrean, Iacob Domsa, Victoria Ruta, Simina Felicia Țărmure Apr 2024

Metachronous Mucinous Breast Carcinoma And Mucinous Pancreatic Cystadenoma In A Patient With Metabolic Comorbidities; Case Report And A Literature Review, Teodora Gabriela Alexescu, Irina Obada, Angela Cozma, Mirela Georgiana Perne, Olga Hilda Orasan, Vasile Negrean, Iacob Domsa, Victoria Ruta, Simina Felicia Țărmure

Journal of Mind and Medical Sciences

Mucinous breast carcinoma is a rare subtype of mammary neoplasm encountered in medical practice. It represents approximately 1-6% of all breast cancers and is more common in postmenopausal women. There are two subtypes of mucinous breast carcinoma: pure and mixed. We report the case of a 73-year-old Caucasian woman diagnosed with mucinous pancreatic cystadenoma in 2007. She underwent a surgical procedure involving pancreatectomy of the body and tail, along with multiple known cardiovascular and metabolic comorbidities. In November 2019, during a clinical-biological evaluation for associated diseases, a mucinous carcinoma of the right breast was accidentally detected and later confirmed through …


Surgical Management Of Retroperitoneal Hydatid Cysts - Results On A Group Of Six Patients, Dragos George Popa, Cosmin Vasile Obleaga, Ana Maria Rukie Ahmet, Cristin Constantin Vere, Vlad Ionuț Ducu, Cecil Sorin Mirea, Dan Nicolae Florescu, Mihai Călin Ciorbagiu, Dragoş Marian Popescu, Costin Teodor Streba, Lucian Florescu, Teodor Sas, Lorena Sas Apr 2024

Surgical Management Of Retroperitoneal Hydatid Cysts - Results On A Group Of Six Patients, Dragos George Popa, Cosmin Vasile Obleaga, Ana Maria Rukie Ahmet, Cristin Constantin Vere, Vlad Ionuț Ducu, Cecil Sorin Mirea, Dan Nicolae Florescu, Mihai Călin Ciorbagiu, Dragoş Marian Popescu, Costin Teodor Streba, Lucian Florescu, Teodor Sas, Lorena Sas

Journal of Mind and Medical Sciences

Objectives. Hydatid disease is a potentially lethal parasitic condition caused by the larvae of Echinococcus Granulosus; it is found in humans and more commonly in domestic and wild animals in endemic areas. This pathology is frequently encountered in the liver, the hydatid cyst with retroperitoneal location representing a rarely encountered form of evolution. Materials and Methods. In the present paper, we present a study carried out on 6 patients hospitalized in the Surgery Department of the Craiova County Emergency Clinical Hospital. These patients were diagnosed between 2002-2022 with retroperitoneal hydatid cyst or with multiple cysts (including retroperitoneal), being operated and …