Digital Commons Network^™

Woop-Woop! That's The Sound Of Da Immune System: A Story Of Tricky Trypanosomes That Evade The Immune System To Get Into The Brain, Sophia Knaysi

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Friends To Lovers: It's More Than My Favorite Book Trope, Smrami Patel

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

All You Need Is... Netflix And Chill? The Neuroscience Of Sexual Behavior And Hookup Culture, Megan Quinn

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Molecular Mechanisms Of Opioid Use Disorder In Human Brain Models, Emily Mendez

Dissertations and Theses (Open Access)

Opioid use disorder (OUD) is a national and global public health crisis with no end in sight. While studies from animal models hint at widespread epigenetic and transcriptomic alterations of opioid drugs, the molecular consequences of long-term exposure to opioid drugs in human brain is still unclear, and human-centered translational models are necessary to discern the human cell type-specific effects of OUD.

Using postmortem brain Brodmann area 9 (BA9) from the UTHealth Brain Collection for Research on Psychiatric Disorders, I identified angiogenic gene networks perturbed in the RNA and protein of OUD subjects, as well as downregulation of many neuron-correlated …

Novel Roles Of Microtubule-Associated Tau In Radiation-Induced Brain Injury, Riya Thomas, Riya Thomas

Dissertations and Theses (Open Access)

Injury responses in cells lacking proliferation capacity such as terminally differentiated neurons consists of complex mechanisms to ensure cellular homeostasis. Brain tumor patients undergoing radiation therapy experience cognitive impairments similar to those seen in patients suffering from neurodegenerative diseases. Despite the plethora of research into radiation effects on proliferating brain cells, the impact of radiation on differentiated, post-mitotic neurons, including their structural and functional alterations, remain largely elusive. However, microtubule-associated tau, an important partner of cytoskeletal structural stability emerges as a pivotal player in the radiation-induced neuronal injury response, demonstrating compartmentalized functions such as repair-centric mechanisms and synaptic homeostasis. This …

The Impact Of Habit Formation On Healthcare Workers: An Occupational Therapy Approach To Well-Being, Hillary Littlefield Msot, Otr/L

All Student Scholarship

Occupational therapists have an opportunity to act as consultants in their healthcare systems to provide education, resources and guidance to interdisciplinary team members. This concept aimed to provide evidence to support an occupational therapy-based program focused on incorporation of healthy habits and routines into one’s daily life as a means to improve nursing altruism, quality of life and perception of one’s successes and value in their occupation. Pre- and post- survey data was utilized to evaluate the effectiveness of an occupational therapy-based initiative that provided 1:1 and group coaching to a population of acute care nurses as an evaluation of …

Legislative Recommendations On Biometric Security And Privacy Jurisprudence, Joshua M. Morrow

All Student Scholarship

This project focuses on the prevalence of biometrics today, their various applications, and the biometric laws and legislations in place in the United States (U.S.) and Maine. Due to various threats and vulnerabilities imposing risk on collecting and using peoples’ biometric data, sufficient cyber protections related to citizens’ privacy rights, ethical control, and security of personally identifiable information (PII) must become necessary components of contemporary biometric laws and legislation. Without such explicit cyber protections, citizens participate in and comply with various technical domains and entities, such as private companies and governmental agencies, with minimal awareness or comprehension that their sensitive …

Conversations About Telehealth Eating Disorder Treatment: Participants Share Their Experiences, Rachel Allen Msw

All Student Scholarship

This phenomenological study explores the use of telehealth as a modality in the treatment of eating disorders through the lenses of feminist, standpoint, and social constructionist theories. At the onset of the COVID-19 pandemic, telehealth was utilized to offer continuity of service at a local, urban eating disorder treatment program in the Northeast. Post pandemic, this modality continued for staffing and accessibility reasons. However, little is known about this treatment from the perspective of service recipients. Intensive semi-structured interviews were conducted via Zoom with six adults who had completed the telehealth program to learn about individuals’ experiences with this modality. …

The Influence Of Environmental Conditions On Gordonia Terrae -Specific Bacteriophage Distribution And Diversity, Gt M. Moore

Biology Theses

Bacteriophages are viruses that infect a diverse range of bacteria, with certain strains serving medical and industrial significance. Actinobacteriophages are viruses that specifically infect Phylum Actinobacteria hosts including the environmentally abundant Gordonia terrae. Some species of Gordonia, including G. terrae, have also been isolated from human infections. The isolation and characterization of novel phages that can infect Gordonia can therefore be significant to both genomics and potential phage therapy. Actinobacteriophages that infect these bacteria have been isolated from soil environments, but optimal environmental parameters for isolation have not been fully evaluated. This study examined the relationships between environmental …

Harnessing Pliancy Tree Soft Sets In Heart Diseases For Extracting Beneficial Rules Of Association Rules, Gawaher S. Hussein, Khalid A. Eldrandaly, Abdelnasser H. Zaied, Samar L. Elhawy, Mona Mohamed

Neutrosophic Sets and Systems

Cardiovascular diseases (CVDs)continue to be the primary cause of mortality, accounting for approximately one-third of all fatalities globally. This spawned the proposal of models in several studies. Accordingly, this study contributed to diagnosing heart disease through suggesting soft diagnosis paradigm. Various techniques have been volunteered for serving the suggested paradigm toward achieving its objective. Additionally, this study provided set of contributions. For instance, Tree Soft Technique (TrST) is applied for the first time for forming attributes and sub attributes of patients into nodes and sub-nodes of Tree to obtain relations between it. Even, the study support stakeholders to making accurate …

Pythagorean Neutrosophic Triplet Groups, Madad Khan, Muhammad Zeeshan, Saima Anis, Florentin Smrandache

Neutrosophic Sets and Systems

It is a well-known fact that groups are the only algebraic structures having a single binary operation that is mathematically so perfect that it is impossible to introduce a richer structure within it. The main purpose of this study is to introduce the notion of the Pythagorean neutrosophic triplet (PNT) which is the generalization of neutrosophic triplet (NT). The PNT is an algebraic structure of three ordered pairs that satisfy several properties under the binary operation (B-Operation) " " . Furthermore, we used the PNTs to introduce the novel concept of a Pythagorean neutrosophic triplet group (PNTG). The algebraic structure …

Utility Of Neurodynamic Techniques In Diabetes Mellitus From The Plitogenic Statistical Approach, Lisbeth Josefina Reales Chacón, Josselyn G. Bonilla Ayala, Andrea Carolina Peñafiel Luna, Paul Adrian Arias Cordova, Angela Campos Moposita

Neutrosophic Sets and Systems

Diabetes mellitus type 2 is an illness condition in which the glucose level is abnormal and causes harm to the peripheral nervous fibers originating the diabetic neuropathy. The major frequent damage occurs in the sensory-motor system, whose sym ptoms include alteration in tactile perception, temperature, and loss of sensitivity in hands and feet. The evidence for treatments that include neural mobilization is limited, so this study aims to determine if intervention strategies with neural mobilization improve both sensory and functional responses in the neuropathy diabetic peripheral. We selected plithogenic statistics to carry out the statistical study because this disease is …

Analysis Of Scientific Production On Neutrosophy: A Latin American Perspective, Oscar E. Velázquez-Soto, Eduardo Enrique Chibas Muñoz, Maykel Leyva Vazquez, Lee Yang Díaz Chieng, Jesús Estupiñan Ricardo

Neutrosophic Sets and Systems

Neutrosophy is a branch of philosophy proposed in 1998 by Romanian philosopher and mathematician F. Smarandache, which studies the origin, nature, and scope of neutrality and its interaction with different spectra of ideas. Because it is a relatively new field, specific scientific production on this subject may be limited, but as it develops, new research and contributions are likely to emerge. This is why it is becoming more necessary to undertake studies to understand the evolution, impact, and scope of research, especially in a context where it had never been examined in depth before: in the Latin American region. This …

Promoting Situational Interest In Computer Science Classroom: A Utility Intervention Approach, Mustafa Gunozu

UNLV Theses, Dissertations, Professional Papers, and Capstones

Mastery of computer science and computational reasoning emerges as an essential skill for every student. Experts recommend increasing the focus on computer science studies due to their crucial role in the future, recognizing its pivotal role in early learning. The present study aimed to evaluate the impact of a utility-based intervention on enhancing middle school students' interest in computer science. This study adopted a utility value intervention method to improve students' situational interest in computer science within a formal setting. The study investigated how a utility intervention changes students' interests in the content, employing a pretest-posttest control group design. For …

Travel-Time Disparities In Access To Proton Beam Therapy For Cancer Treatment, Todd Burus, Alexander Vanhelene, Michael Rooney, Krystle Lang Kuhs, W. Jay Christian, Christopher Mcnair, Sanjay Mishra, Arnold Paulino, Grace Smith, Steven Frank, Jeremy Warner

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

IMPORTANCE: Proton beam therapy is an emerging radiotherapy treatment for patients with cancer that may produce similar outcomes as traditional photon-based therapy for many cancers while delivering lower amounts of toxic radiation to surrounding tissue. Geographic proximity to a proton facility is a critical component of ensuring equitable access both for indicated diagnoses and ongoing clinical trials.

OBJECTIVE: To characterize the distribution of proton facilities in the US, quantify drive-time access for the population, and investigate the likelihood of long commutes for certain population subgroups.

DESIGN, SETTING, AND PARTICIPANTS: This population-based cross-sectional study analyzed travel times to proton facilities in …

Bootstrapping For Estimating The Conservative Kill Ratio Of The Surrogate To The Pathogen For Use In Thermal Process Validation At The Industrial Scale, Arshpreet Kaur Khattra, Surabhi Wason, Kevin Thompson, Andy Mauromostakos, Jeyamkondan Subbiah, Jennifer C. Acuff

Food Science Faculty Publications and Presentations

A surrogate is commonly used for process validations. The industry often uses the target log cycle reduction for the test (LCR_Test) microorganism (surrogate) to be equal to the desired log cycle reduction for the target (LCR_Target) microorganism (pathogen). When the surrogate is too conservative with far greater resistance than the pathogen, the food may be overprocessed with quality and cost consequences. In aseptic processing, the Institute for Thermal Processing Specialists recommends using relative resistance (D_Target)/(D_Test) to calculate LCR_Test (product of LCR_Target and relative resistance). This method uses the mean values …

Impact Of Sustained Calorie Restriction And Weight Cycling On Body Composition In High-Fat Diet-Fed Male And Female C57bl/6j Mice, Daniel L Smith, Yongbin Yang, Luis M Mestre, Beate Henschel, Erik Parker, Stephanie Dickinson, Amit Patki, David B Allison, Tim R Nagy

Children’s Nutrition Research Center Staff Publications

Objective: The objective of this study was to investigate body composition changes with weight cycling (WC) among adult C57BL/6J mice with diet-induced obesity.

Methods: A total of 555 single-housed mice were fed a high-fat diet ad libitum (AL) from 8 to 43 weeks of age. The 200 heaviest mice of each sex were randomized to the following four groups: ever obese (EO, continued AL feeding); obese weight loser (OWL, calorie-restricted); obese weight loser moderate (OWLM, body weight halfway between EO and OWL); and WC (diet restricted to OWL followed by AL refeeding cycles). Body weight and composition data were collected. …

An Intelligent Academic Advising System For Course Recommendation Using Large Language Models, Malika Maya Iratni

Theses

Academic advising is an important resource for students, especially in higher education, in order to guide them to make the best possible decisions to improve their overall academic performance and overall academic journey. With the increasing number of students joining these institutions each year, traditional advising becomes a time-consuming and inefficient process that can leave students discouraged, and advisors overwhelmed. Therefore, there is a need to develop intelligent advising systems that make use of the recent advancements in technology, to support the advising process, and increase overall student satisfaction. In this work, an academic advising model that uses Recommender Systems …

Gene Patents: Striking The Right Balance Between Incentive And Innovation, Josh Saul

Fordham Law Review

The U.S. Supreme Court held human genes to be unpatentable subject matter in Association for Molecular Pathology v. Myriad Genetics, Inc. The implications from this decision were, and to a large extent still are, unclear. However, in the decade since this decision, a number of studies have begun to shed light on the fallout of Myriad. This Note examines such studies and finds that they suggest a decline in investment and innovation in the biotech industry. In order to promote research and innovation in the field of genetics, this Note then advocates for legislative action to reestablish the …

Factors Influencing Uae High School Chemistry Students' Learning Of Organic Qualitative Analysis: A Qualitative Study, Manal Abdullah Almahdawi

Dissertations

Chemistry is one of the five science subfields typically covered in secondary schools in the United Arab Emirates. Chemistry is a branch of science that studies substances' characteristics, components, and structures. Numerous subfields fall under the umbrella of chemistry, including inorganic, organic, analytical, and physical chemistry. One of the topics covered in chemistry classes is the analysis of chemical compounds, which is divided into two types: quantitative analysis and qualitative analysis. While qualitative analysis determines the kind of each element or group present in a given solution sample, quantitative analysis determines the quantity of each element or group present. Students' …

Sharp Injuries And Splash Exposures Among Healthcare Workers In The United Arab Emirates, Ibtisam Aref Karkaz

Dissertations

Brief introduction: Occupational injuries, including sharps injuries and splash exposures, pose significant risks to healthcare workers worldwide. These incidents can lead to the transmission of bloodborne infections, resulting in substantial healthcare costs and workforce challenges. Aims: The present study aimed at investigating sharps injuries and splash exposures among healthcare workers in Abu Dhabi government hospitals. To achieve the aim, the study planned to determine the frequency of sharps injuries and splash exposures, and to identify their risk factors, applied preventive measures, and consequent occupational infections. Method: Secondary data from the available records of all sharp injuries and splash exposures reported …

Phenolic Compounds In Date Fruits (Phoenix Dactylifera L.), Muneeba Zubair Alam

Dissertations

This study investigated the phenolic compounds in date fruits, mainly soluble and hydrolyzable compounds, and insoluble melanin. Soluble (27.5–54.0 mg/100 g FW) and hydrolyzable (24.0–78.5 mg/100g FW) phenolic compounds were determined in 18 cultivars using ultra-performance liquid chromatography coupled with mass spectrometry. Phenolic acids were predominant in both fractions while flavonoids were mainly present in the soluble phenolic fraction and the proanthocyanidin B1 and B2 were only present in the hydrolyzable fraction. Four total antioxidant activity assays (total phenolic content, ABTS, FRAP, and DPPH) gave different results for both the soluble and hydrolysable fractions of 26 date fruit cultivars, which …

Valorization Of Date Palm Waste For The Isolation, Characterization, And Surface Chemistry Modification Of Nanocellulose, Mohsin Raza

Dissertations

This dissertation focuses on the utilization of date palm waste, a lignocellulosic material, as a source for the extraction of nanocellulose (NC), a versatile biopolymer with applications in biodegradable composites, bioplastics, and food packaging. Conventional methods of NC production using mineral acids such as sulphuric and hydrochloric acid are reaching their limits of toxicity, so more environmentally friendly alternatives such as ionic liquids (ILs) are being explored. The research focuses on the characterization of different date palm wastes to evaluate their α−cellulose content, lignocellulosic character, and thermal stability. By comparing extraction methods with mineral acids and ILs, the study evaluates …

The Role Of Abu Dhabi's Nearshore Marine Environments In The Ecology Of Elasmobranch Fishes, Stephan Bruns

Dissertations

This dissertation investigated the role of inshore habitats in the ecology of elasmobranch fishes, with a specific focus on the wider Khor Fardiah Region on the eastern site of Abu Dhabi City. Once the vulnerability of these environments to anthropogenic pressure and climate change is recognised, it is clear that nearshore environments are susceptible to adverse outcomes. Hence, this dissertation aims to provide informative data that can help in devising effective conservation strategies. The study used a multi-survey technique approach, including stereo-BRUVS, acoustic telemetry, and satellite tracking, in combination with local ecological knowledge to explore the species diversity and habitat …

Development Of A Model To Predict Maximum Crack Width And Spacing In Reinforced Concrete Beams Under Flexural Stress, Saeed Alghamdi

Theses and Dissertations

Cracking in reinforced concrete structures is unavoidable due to the low tensile strength of concrete. Even though minimizing cracks on exposed concrete surfaces is significantly important from the aesthetics point of view, it is also very important for the durability and overall performance of the structure.

Flexural members must be designed to minimize cracking that may occur during the structure's service life. Even though there has been a lot of experimental work on crack width over the last several decades, a literature review reveals that researchers still can't agree on which variables are most important. Part of the reason for …

Optimization Of Coral Restoration Along The Florida Reef Tract, Raymond Barry Banister

Theses and Dissertations

Historically, the reefs of Florida were dominated by two framework-building corals, Acropora cervicornis and A. palmata. However, these two populations have declined by 95% since the 1970s. The predominant contributors to the coral decline have been ocean warming and disease. In response to the decline, restoration organizations were established to improve survival, growth, and reproduction. Yet, there are gaps in current restoration practices and our knowledge of effective restoration techniques. This study uses large datasets to develop models that predict the most optimal locations for coral restoration in Florida and examines the relationships between the occurrence of wild acroporids …

Improving Static Cold Storage Life Of The Human Heart Before Transplant, Juan Sebastian Rodriguez Paez

Theses and Dissertations

Organ storage and transportation are critical steps for the success of organ transplantation. Static cold storage (SCS) of hearts for heart transplantation (HTx) remains the standard approach. However, SCS may involve damage to the tissue resulting from extended hypothermic preservation, potentially affecting organ viability. More over, the temperature distribution on and within the heart is unknown during heart transplantation. Therefore, there is an interest to study different stages of the heart transplantation process towards determining the 3D temperature distribution on and within the heart. There could be a possibility of having a hypothermic injury in different parts of the heart …

Modelling Terrestrial And Potential Extraterrestrial Photopigments Via Density Functional Theory, Dorothea Illner

Theses and Dissertations

In the search for extraterrestrial life, biosignatures play a crucial role in identifying its putative traces. A commonly known and robust biosignature is the Vegetation Red Edge (VRE), which can be described as a sharp increase of reflectance observed from a planet and stems from the light absorption of photopigments in specific regions in the electromagnetic spectrum. For Earth, this VRE is known to occur around 700 nm, however, if the photopigments absorb light in different regions and have different structures the VRE could experience a wavelenght shift.

In this work, Chlorophyll a and a potential photopigment precursor called Phot0 …

Microwave Imaging Technique For Breast Cancer Detection, Nure Alam Chowdhury

Theses and Dissertations

Breast cancer is a global problem, and it is inevitable to detect cancerous cells at early stages. In recent years, microwave imaging technology has been widely applied in biomedical applications for its non-ionizing radiation. In this study, we design a micro-strip patch antenna with an inverted T-type notch in the partial ground to detect tumor cells inside the human breast. The size of the current antenna is small enough (18 mm × 21 mm × 1.6 mm) to distribute around the breast phantom. The operating frequency has been observed from 6–14 GHz with a minimum return loss of −61.18 dB …

Denoising Diffusion Probabilistic Models Based Accelerated Mri, Alexander Francis Bugielski

Theses and Dissertations

Magnetic Resonance Imaging (MRI) is a cornerstone in obtaining intricate visualizations of anatomy and physiological processes within the human body. However, its extensive scan duration not only causes patient discomfort but also increases the likelihood of motion-induced artifacts in the images. To address such a challenge, this study investigates deep neural network models for reconstructing high-resolution MRI images from noisy and significantly undersampled data in a supervised learning manner. Specifically, it compares three models: a conventional U-Net, a self-attentive U-Net, and an innovative probabilistic diffusion model that builds upon the self-attentive U-Net architecture. These models are evaluated on their ability …