Digital Commons Network^™

Multidisciplinary Literary Review: The Relationship Between Social Media And Empathy, Mayra E. Salgado

Honors Theses

This literary review examines the different psychological perspectives on the relationship between social media usage and empathy. Specifically, it discusses the association by expanding on the fields of cognitive psychology, neuropsychology, clinical psychology, and some evolutionary psychology. I define empathy and discuss its developmental journey, its cognitive functions, its neurobiological processes, its possible damage caused by social media usage, and its effects on physical and mental health. Lastly, I argue that research focusing on high levels of social media usage and its relationship with levels of empathy should focus on creating an elaborate longitudinal study to gain more information on …

Understanding Taf13 (Tata Box-Binding Protein-Associated Factor 13) Upregulation In Eukaryotic Cells, Selin Kaplanoglu

Honors Theses

TATA-binding protein (TBP) and TBP-associated factors (Tafs) comprise RNA Polymerase II (RNA Pol II) pre-initiation complex. This universal component carefully controls the transcriptional initiation process. One of the Tafs, Taf13, also plays an important role in the regulation of RNA Pol II transcription initiation which is evolutionarily conserved from yeast to humans. It is found that Taf13 is overexpressed in cancer cells, although the exact mechanism that is responsible for this overexpression is unclear. Our hypothesis suggests that targeted degradation by the 26S proteasome via ubiquitylation [Ubiquitin-Proteasome System (UPS)] may be the mechanism that regulates the stability of Taf13. To …

Elucidation Of The Overexpression Of Taf2 In Eukaryotic Cells, Morgan Osborn

Honors Theses

Through several studies, Taf2 has been found to be upregulated in various cancer cells. However, the mechanism through which this increased expression of Taf2 occurs remains unknown. As evolutionarily conserved ubiquitin-proteasome system (UPS) maintains protein homeostasis for normal cellular function, we hypothesized that stability of Taf2 may be regulated by this UPS and this UPS may be dysregulated in cancer cells causing overexpression of Taf2. To test our hypothesis, we assessed the role of the UPS in the regulation of the stability of Taf2 by 26S proteasome-mediated degradation. To do so, we performed molecular experiments mainly through two steps: 1st …

Associations Between Gut Microbiome Metabolomics And Endometriosis Risk, Progression, And Non-Invasive Diagnosis: A Review, Marlee Sanders

Honors Theses

Endometriosis is a gynecological condition that affects 1 in 10 women of reproductive age, is characterized by growth of endometrial tissue outside of the uterus, and encompasses metabolic, immunologic, and endocrine dysfunction. Despite its significant impact, endometriosis remains inadequately studied within the realm of women's health, emphasizing the crucial need for innovative approaches in the analysis and diagnosis of this complex condition. The cause of endometriosis is unknown however it could be influenced by genetics, environmental factors, diet, lifestyle, and notably composition of the gut microbiome. Recent scholarly interest has sparked inquiries into the correlations between endometriosis and the gut …

Determining The Antimicrobial Activity And Permeabilizing Effects Of Polyunsaturated Fatty Acids And Piscidins On Vibrio Parahaemolyticus And Vibrio Vulnificus, Christina Harris

Honors Theses

Antimicrobial peptides (AMPs) are found in all organisms and have gained attention for their effectiveness against a variety of pathogens. Piscidins are AMPs that were discovered in mast cells of vertebrates, mostly within marine animals, and are an important part of the innate immune system due to their potent antimicrobial properties. Piscidin 1 (P1) and piscidin 3 (P3) are found within sea bass and have different antimicrobial activities. P1 exhibits strong membrane disruptive properties, while P3 goes through the membrane to the targeted DNA. These piscidins can experience metalation with copper (Cu2+) which enhances their antimicrobial activity in vitro (P1-Cu2+ …

A Study Of The Relationship Between Interoceptive Sensibility And Distress Tolerance In Community And College Samples, William Moore

Honors Theses

Interoceptive sensibility (IS) involves the detection, integration, and interpretation of internal bodily signals, primarily from cardiovascular, pulmonary, or gastrointestinal systems. Dysfunction in interoceptive processing has been increasingly recognized as a clinically relevant factor in numerous neurological, psychiatric, and behavioral disorders. This thesis aimed to elucidate the relationship between interoceptive sensibility and distress tolerance, hypothesizing that individuals with heightened interoceptive sensibility may exhibit poorer distress tolerance, potentially influencing emotional regulation and maladaptive coping mechanisms. To explore these relationships, two studies have been conducted utilizing self-report measures of interoceptive sensibility and distress tolerance in community and college samples. In a study of …

Designing An Experiment For Playfulness In A Virtual Environment For Enhanced Creative Climate, Donnalyn Roxey

Creativity and Change Leadership Graduate Student Master's Projects

This project investigated the integration of playfulness into virtual workshop environments to enhance creativity and participant engagement. The initial focus was on developing an online game to encourage mind-wandering and creative expression. However, research and discussions with faculty revealed practical challenges and potential distractions associated with implementing this idea. The project pivoted towards exploring alternative interventions and ended up with two interventions for virtual workshops as well as a companion blog with practical strategies. A "wreck-it" style welcome package containing fidget toys and creative prompts was proposed for individual participants. Additionally, a modified version of an in-person activity was designed …

Exploring Interoception - An Essential Skill Of Exceptional Self-Leadership, Suzanne Dameron

Creativity and Change Leadership Graduate Student Master's Projects

Research into interoception, the awareness of the body’s inner state, suggests that the body is the true star in the mind-body relationship. Interceptive findings suggest that when we pay attention to our physical sensations – twinges, tingles, a quickening heartbeat – we have a depth of information now available to us that enhances our self-awareness and self-leadership. This paper is the result of exploring the theory and practice of developing interoceptive awareness and its implications for self-leadership.

Balancing Act: An Exploration Of Polarities In Personal And Professional Life, Hana Mamnoon

Creativity and Change Leadership Graduate Student Master's Projects

This purpose of this project is to explore the concept of polarities. I have been using creative problem solving for years, but recently, I have come to realize that some of the complexities we face in our everyday lives are not actually problems to solve, but rather are polarities to manage (Johnson, 2014). By undertaking this project, I aimed to build my skill set around polarity management in order to help me develop in both my personal and professional spheres. This project allowed me to explore some of the literature of polarities as well as put the concepts into practice …

A Review Of Rheb Activation Of Mtorc1 And The Great Mystery Of One Missing Gef, Jack Gregory

Senior Honors Theses

The mTORC1 pathway is involved in the regulation of cell growth and translation. The pathway has a complex web of activators and inhibitors to activate mTORC1. mTORC1 is regulated via a small GTPase called Rheb, which interacts directly with mTORC1. This GTPase and its GTPase activating protein (GAP), TSC1/2, have been widely studied to understand how the variety of regulators of mTORC1 interact with these proteins. Despite this, the guanine nucleotide exchange factor (GEF) of Rheb has yet to be identified. This review broadly analyzes Rheb and mTORC1, their structures, regulations, and interactions, and explores the mystery of the missing …

Potential Abatement Of Bay Nettle (Chrysaora Chesapeakei) Blooms Through Polyp Removal Within Lagoon Communities In Barnegat Bay, Nj, Anthony Luca Tamberelli

Theses, Dissertations and Culminating Projects

Jellyfish blooms have gained increased attention in recent decades due to their negative impacts on ecosystems and human activities. Urban development, pollution, and overfishing are some of many possible impacts that can bolster the frequency, duration, and intensity of jellyfish blooms. In Barnegat Bay, NJ, USA, the invasive bay nettle Chrysaora chesapeakei exerts top-down predation pressure on zooplankton, including ctenophores, hydrozoans, crustaceans, and ichthyoplankton. Bay nettle populations rely on hard substrates for larval settlement and polyp clonal growth. To determine whether abatement efforts targeted at bay nettle polyps can disrupt the life cycle and limit medusae populations, a three-year sampling …

Lived Experiences, Migration Journey, Religiosity, And Spirituality Depicted In Drawings By Latino Children And Youth Crossing The U.S. Mexican Border: A Qualitative Study., Doroty Magalhaes Sato

Electronic Theses and Dissertations

Widespread violence forces thousands of Central American children to endure a hazardous journey toward the U.S. Border seeking refuge. In the Latino community, faith serves as a social movement of resistance against oppression, playing a vital role in migration. There is a paucity of research documenting this experience and children's overall journey. Therefore, this study aimed to investigate the lived experience of crossing international borders, religiosity, and spirituality depicted in Latino children's drawings used as coping methods to endure the journey toward the U.S. southern border. This investigation employed Art-based approaches to give voices to children's experiences by analyzing 63 …

Macrophage Polarization And Colorectal Cancer Immune Checkpoint Protein Expression., Anne Macleod

Electronic Theses and Dissertations

The majority of patients with colorectal cancer do not respond to treatment with immunotherapy. Immunotherapy requires the expression of cell surface immune checkpoint proteins (e.g. PDL1) to exert its effect. Most (>85%) of colorectal cancers do not express these proteins and this contributes in part to the poor prognosis and survival in patients with advanced disease. The patients in which immunotherapy is a potential treatment option, are a genetic subtype known as mismatch repair deficient, and have demonstrated an excellent response to anti-PD-1/PDL1 immunotherapy. A key feature of mismatch repair deficient (MMRd) cancers is their immune cell rich tumor …

A Multiple-Methods Assessment Of Faculty Attitudes Toward Inclusive Instruction., Kate A. Snider

Electronic Theses and Dissertations

The enrollment landscape of postsecondary institutions in the United States has undergone significant demographic shifts, marked by increasing racial and ethnic diversity and a rise in enrollment of students with disabilities. Recognizing the importance of accommodating diverse learners, this study investigates faculty attitudes toward inclusive instruction, Universal Design for Instruction, and disability-related topics. This multiple-methods study aimed to identify differences across faculty groups to establish an initial measure of faculty attitudes toward inclusive teaching practices that can be used to design future training or professional development opportunities. Data was collected via an online distribution of the Inclusive Teaching Strategies Inventory …

Pre-Columbian Soil Management, Settlement, And Land Use In Amazonia: Insights Using Micro-Regional Predictive Modelling In Gurupá, Brazil., Lauren Zacks

Electronic Theses and Dissertations

The results of a micro-regional predictive model of terra preta sites in the municipality of Gurupá are presented here. A Maximum Entropy approach was selected and modified to fit a presence-background model, rather than a presence-absence model typical of binary classifications. 13 known terra preta sites were used as input samples for the relative suitability model, with explanatory variables in the respective categories of topography, hydrology, soil type and vegetation index. A 30m spatial resolution DEM served as the basis for the former two categories, while additional TauDEM analysis was performed for the hydrology category. A Sentinel-2A mosaicked quarterly composite …

In-Training Explainability Frameworks To Make Black-Box Machine Learning Models More Explainable., Asuman Cagla Acun

Electronic Theses and Dissertations

Despite ongoing efforts to make black-box machine learning models more explainable, transparent, and trustworthy, there is growing advocacy for using only inherently interpretable models for high-stake decision-making. Post-hoc explanations have recently been criticized for learning surrogate models that may not accurately reflect the actual mechanisms of the original model and for adding computational burden at prediction time. We propose two novel explainability approaches to address these limitations: pre-hoc explainability and co-hoc explainability. These approaches integrate explanations derived from an inherently interpretable white-box model into the learning stage of the black-box model without compromising accuracy. Unlike post-hoc methods, our approach does …

A Qualitative Inquiry Into The Intersectionality Of Race, Gender, And Social Networks In Stem Education., La'ree Alexandria Shontee

Electronic Theses and Dissertations

This study explores the intersectional experiences of Black women in Science, Technology, Engineering, and Mathematics (STEM) education by focusing on the strategic utilization of social capital to navigate systemic barriers and challenges. The unique struggles faced by Black women within predominantly white and male-dominated STEM programs are addressed in this study. Drawing on a growing body of literature, this research diverges from prevailing narratives of disinterest in or departure from STEM programs and instead illuminates proactive strategies employed by Black women. Through an exploration of social capital - encompassing networks, resources, and support systems - this study offers a comprehensive …

A Qualitative Exploration Of Social Capital And Its Influence On Baccalaureate Degree Completion Of First-Generation African American Men At The University Of Louisville., Joseph Marshall Goodman Iii

Electronic Theses and Dissertations

This qualitative dissertation was designed to examine influences which various forms of social capital have on post-secondary degree attainment of first-generation individuals who self-identify as African American men. Additionally, the sample population consisted of Black men who successfully matriculated to earn baccalaureate credentials across differing academic disciplines at a public historically White institution located in the mid-south region of the United States. The research data was extracted from one-on-one, semi-structured interviews using authentic dialogue through open-ended questions. Theoretical paradigms of the study involved a phenomenological approach and an ontological philosophical assumption, integrated with critical theory, critical race theory and social …

The 2022 Symposium On Dementia And Brain Aging In Low- And Middle-Income Countries: Highlights On Research, Diagnosis, Care, And Impact, Raj Kalaria, Gladys Maestre, Simin Mahinrad, Daisy Acosta, Rufus Akinyemi, Suvarna Alladi, Ricardo Allegri, Faheem Arshad, Wambui Karanja, Chinedu Momoh

Brain and Mind Institute

Two of every three persons living with dementia reside in low- and middle-incomecountries (LMICs). The projected increase in global dementia rates is expected toaffect LMICs disproportionately. However, the majority of global dementia care costsoccur in high-income countries (HICs), with dementia research predominantly focus-ing on HICs. This imbalance necessitates LMIC-focused research to ensure thatcharacterization of dementia accurately reflects the involvement and specificities ofdiverse populations. Development of effective preventive, diagnostic, and therapeu-tic approaches for dementia in LMICs requires targeted, personalized, and harmonizedefforts. Our article represents timely discussions at the 2022 Symposium on Demen-tia and Brain Aging in LMICs that identified the foremost …

A Systematic Review Of Mental Health Of Women In Fragile And Humanitarian Settings Of The Eastern Mediterranean Region, Fauziah Rabbani, Aysha Zahidie, Amna Siddiqui, Sanam Shah, Zul Merali, Khalid Saeed, Mohamed Afifi

Brain and Mind Institute

Background: The increasing emergencies and humanitarian challenges have worsened the mental health condition of women in the Eastern Mediterranean Region.

Aim: To assess the prevalence, determinants and interventions to address mental health among women in fragile and humanitarian settings in the Eastern Mediterranean Region.

Methods: Using the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines, we reviewed 59 peer-reviewed published studies (PubMed, IMEMR) and grey literature (WHO/IRIS) from January 2001 to February 2023, focusing on women's mental health in the Eastern Mediterranean Region. We then conducted a descriptive analysis of the sociodemographic characteristics.

Results: Among …

Gender Equality Threatened: A Digital Communication Analysis Of Spanish Right-Wing Political Parties, Daisy Rehbock

International and Global Studies Undergraduate Honors Theses

Spanish right-wing political parties have become incredibly active on social media within the last decade, especially with the creation of the ultra-right wing party Vox, which now has the most followers of any Spanish political party across all social media platforms. The usage of social media by right-wing political parties is a populistic approach that allows politicians to connect directly to their voter base instead of utilizing more ‘elitist’ forms of media. This paper is focused on analyzing the rhetoric of two right-wing Spanish political parties, Vox and Partido Popular, in order to gauge their stances and impacts on gender …

Edra 55: Bibliography, Tamara Karr

Bibliographies

edra 55: Human-Centric Environments

Amphipathic Hybrid Cyclic-Linear Peptides As A Drug Delivery System, Jonathan Moreno

Pharmaceutical Sciences (PhD) Dissertations

Amphipathic Hybrid Cyclic-Linear Peptides as a Drug Delivery System by Jonathan A. Moreno Peptides

[RW]₄ and [R₅W₄] have been previously identified as molecular transporter Cell Penetrating Peptide (CPP) and antimicrobial agents, respectively. These peptides consisted of alternating and non-alternating arginine (R) as positively charged residues and tryptophan (W) as hydrophobic residues. Herein we report the synthesis of two hybrid amphipathic cyclic-linear cell-penetrating peptides [RW]₄K-AH135 (1) and [R₅W₄]K-AH135 (2) composed of [RW]₄ and [R₅W₄] and a linear peptide AH-135 (Ac)NH-RWLRRWLRWWRR-COOH. The …

Approvals, Utilization, And Cost Of Biologics For The Treatment Of Rheumatoid Arthritis, Roya Hosseini

Pharmaceutical Sciences (PhD) Dissertations

Introduction: RA treatment has been revolutionized by the development and approval of biologic disease-modifying antirheumatic drugs (bDMARDs). However, the approval status, utilization, and high cost of bDMARDs pose challenges in RA management.

Objectives: This dissertation evaluated the association between the utilization of bDMARDs and the sociodemographic characteristics of the RA patient population. It also identified the FDA approval status of bDMARDs and assessed the annual cost of bDMARDs used in RA treatment, evaluated the factors explaining annual cost at market entry.

Methods: In the retrospective analysis of Medical Expenditure Panel Survey (MEPS) data from 2010-2021, the population includes RA patients …

Mechanistic Study Of Antimicrobial Cyclic Peptide [R4w4] Antibacterial Effectiveness Against Methicillin-Resistant Staphylococcus Aureus (Mrsa), Ajayi Akinwale

Pharmaceutical Sciences (PhD) Dissertations

Antimicrobial peptides (AMPs) are being explored as a potential solution to combat antibiotic resistance, as they have shown promise in reducing susceptibility to antibiotics. This study explores if [R₄W₄] peptide is bacteriostatic or bactericidal using modified two-fold serial dilution and evaluates synergism of gentamicin and [R₄W₄] against Escherichia coli (E. coli) and Methicillin-resistant Staphylococcus aureus (MRSA) by checkered board assay. The MRSA resistant to [R₄W₄] and possibility with other antibiotics was evaluated with serial passage. Moreover, we investigated the mechanism of action of [R₄W_{4 …}

De-Escalating The United States-China Trade War Using A Global Conflict Resolution Methodology Framework, Angelina Kapp

Undergraduate Honors Theses

How can the United States and China collaboratively de-escalate their current trade relationship using a conflict resolution methodology to foster economic growth and foreign investor confidence in the evolving landscape of global trade? This paper will serve as a guide to those wanting to gain a comprehensive understanding of the macroeconomic causes and impacts of the contentious trade war between the U.S. and China. The year 2018 can be attributed to the start of the war when then-President Donald Trump implemented tariffs on Chinese goods and products. These back-and-forth financial and economic measures have been continually imposed to this day …

Fate Of Per- And Polyfluoroalkyl Substances In A Wastewater Treatment Facility Using A Novel Membrane Bioreactor, Lindsay Ann Guertin

Master's Theses and Capstones

Per- and polyfluoroalkyl substances (PFAS) are a broad class of chemicals known for their environmental persistence and unique thermal and chemical stability which has led them to be used in a variety of products including paper, carpets, clothes, cosmetics, food packaging, kitchen ware, chrome plating, and aqueous film forming foams (AFFFs). Their resistance to biochemical degradation has led regulators to be interested in reducing PFAS loads to the environment and sources that humans are exposed to (e.g. drinking water). Recent studies have shown that concentrations of some terminal PFAS increase after secondary (biological) wastewater treatment indicating that precursor compounds are …

Characterizing Modality And Cognitive Effects In Implicit-Statistical Learning: Theoretical Implications For Language Learning In Adults, Katelyn Lerner

Master's Theses and Capstones

This study examined the presence of modality and cognitive effects within implicit statistical learning (ISL) to characterize how it operates within the context of language learning. The first research aim looked to investigate differences in ISL performance as it relates to modality, specifically auditory versus visual formats. Additionally, the relationship between cognitive measures and ISL task performance was investigated to characterize potential interactions between learning and cognition. In this study healthy adults between the ages of 18-35 were administered auditory and visual ISL experimental tasks. Participants were familiarized with a target grammar pattern in an exposure phase. After the exposure …

Suspended Ion Exchange For Extensive, Low-Energy And N2o-Emission-Free Removal Of Nitrogen In Municipal Purification, Bailey Jones

Master's Theses and Capstones

In recent years, high concentrations of anthropogenic ammonia have been measured in surface and groundwaters in Europe which can devastate ecosystems due to eutrophication. Sources of this excess ammonia are fertilizers used in the agricultural industry and municipal wastewater discharge. Stricter regulations limiting the amount of ammonia a wastewater treatment plant (WWTP) can discharge may be enacted soon to prevent ammonia’s negative effects. A major issue facing WWTPs in the Netherlands is that conventional biological treatment processes used by these facilities are not able to meet the proposed ammonia discharge regulations. These facilities must soon turn to chemical solutions and …

The American Thoracic Society Research Program: Twenty Years Of Driving Discovery In Respiratory Medicine, Kamran Atabai, M. Safwan Badr, Jack Costello, Karen Ridge, Sharon Rounds, Michelle Turenne, Eric White, Jesse Roman

Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers

No abstract provided.