Digital Commons Network^™

Male Infertility: A Retrospective Review Of Laboratory Charts At A Tertiary Teaching Hospital In Nairobi City County, Festus Mulakoli, Doris Machaki, Abednego Ongeso, Maureen Akolo, Ruth Wagathu

School of Nursing & Midwifery, East Africa

Background: Globally, approximately 50 million couples experience one form of infertility, and 10 million cases of subfertility have been reported in sub-Saharan Africa. Infertility is characterized by a lack of clinical conception among couples who live together for more than one year with regular coitus, without the use of contraception. Factors related to fertility vary by sex and geographical region. These factors include age, lifestyle, infectious diseases, and genetic disorders. In African culture, children are considered a simple inheritance and a measure of masculinity, so efforts are needed to address the growing problem of male infertility in this context. …

An Investigation Of Information Structures In Dna, Joel Mohrmann

Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research

The information-containing nature of the DNA molecule has been long known and observed. One technique for quantifying the relationships existing within the information contained in DNA sequences is an entity from information theory known as the average mutual information (AMI) profile. This investigation sought to use principally the AMI profile along with a few other metrics to explore the structure of the information contained in DNA sequences.

Treating DNA sequences as an information source, several computational methods were employed to model their information structure. Maximum likelihood and maximum a posteriori estimators were used to predict missing bases in DNA sequences. …

Disrupting Negative Representations Of Queerness In Genre Cinema, Mark Gambino

Postgraduate

The stigmatisation of queer identities is a constant in cinematic history, especially so in horrorgenre movies. A transgressive and confronting medium, horror cinema presents numerous opportunities to align queer identities with cultural symbols of degeneracy; perpetuating associations that contribute to negative cultural attitudes towards queerness. While public discourse on such topics has advanced to entertain ideas of equity and authenticity in these representations, negative values and attitudes are yet evident in contemporary cultural texts. Therein lay an opportunity to examine how these attitudes and values are perpetuated through history by deconstructing how societal attitudes inform the creation of a text …

2024 School Of Law Commencement Information And Photographs, Roger Williams University School Of Law

School of Law Commencement (1996- )

No abstract provided.

Postcolonial Analysis Of Equity In The Ghanaian Education System, Enock Yeboah

Kutztown University Masters Theses

The paper contains information on the Ghana education system. As a product of the system, I will explain the Ghanaian education system's structure in the first part of the paper. In this part of the paper, I explain the Ghanaian education system from early childhood to the tertiary level, the assessment practices used in Ghana, and diversity and inclusion in the education sector of Ghana. I will give a brief overview of all the educational levels in Ghana and the age brackets of all levels. Early childhood education in Ghana starts at birth to age 4, and kindergarten starts at …

Choreographing The Rhythms Of Observation: Dynamics For Ranged Observer Bipartite-Unipartite Spatiotemporal (Robust) Networks, Edward A. Holmberg Iv

LSU New Orleans Theses and Dissertations

Existing network analysis methods struggle to optimize observer placements in dynamic environments with limited visibility. This dissertation introduces the novel ROBUST (Ranged Observer Bipartite-Unipartite SpatioTemporal) framework, offering a significant advancement in modeling, analyzing, and optimizing observer networks within complex spatiotemporal domains. ROBUST leverages a unique bipartite-unipartite approach, distinguishing between observer and observable entities while incorporating spatial constraints and temporal dynamics.

This research extends spatiotemporal network theory by introducing novel graph-based measures, including myopic degree, spatial closeness centrality, and edge length proportion. These measures, coupled with advanced clustering techniques like Proximal Recurrence, provide insights into network structure, resilience, and the effectiveness …

Response Of Fish Assemblages To Increased Connectivity And Habitat Restoration In Bayou St. John, A Degraded Waterway In New Orleans, La, Alia Jones

LSU New Orleans Theses and Dissertations

Bayou St. John is a degraded waterway located within the City of New Orleans. The Bayou, which is disconnected from Lake Pontchartrain by floodgates, has undergone restoration efforts to improve connectivity through frequent floodgate openings and marsh habitat restoration outside of the floodgates. To assess possible responses of local fish assemblages to these restoration efforts, I analyzed long-term fish assemblage data from three sites located inside of the floodgates and one site located at the restored marsh outside of the floodgates. Two sites inside of the floodgates experienced significant changes in assemblages between the pre-opening period (2006-2012) and post-opening period …

Super Mario Evolution By The Augmentation Of Topology, Russell A. Autin

LSU New Orleans Theses and Dissertations

This paper describes the creation and development of an implementation of the NeuroEvolution of Augmenting Topologies (NEAT) architecture to train an agent to play Super Mario Brothers. Building off of a basic implementation of NEAT, this thesis project shows the process of refining the fitness calculation that ranks the networks in the population and also defines the creation and application of a dataset to train the agent. The use of a dataset to train an agent is a novel idea in the world of reinforcement learning because, generally, reinforcement learning trains an agent to complete a singular task like the …

A Performance-Based Exploration Of Vocal Anatomy And Pedagogy: Maximizing Technical, Stylistic, And Physiological Frameworks For Superlative Vocal Technique In Artistic Function, Michael J. Civitano

LSU New Orleans Theses and Dissertations

This study investigates the influence of specific frameworks in performance and vocal pedagogy on artists' capacity to enact evidence-based learning outcomes, with emphasis on vocal physiology and educator-performer relationships. Employing an experimental design, five philosophies that support capacity-building were tested across two trial settings, varying in intensity. The participant utilized narrative reasoning, diversified methods, and mentorship from specialized educators to apply frameworks. Findings indicate that, in practicing evidence-based learning and maximizing anatomic foundations of the voice, substantial developments in artistic capacity ensued. Educator-performer relationships mediate this process through reciprocal collaborations that foster capacity-building. Performers display optimal artistic capacity by effectively …

The Pawn System: How Procedurally Adaptive Webbed Narratives Create Stories, Steven T. Bordelon

LSU New Orleans Theses and Dissertations

This thesis describes the design, implementation, and testing of a novel procedural narrative system called the Procedurally Adaptive Webbed Narrative (PAWN) system. PAWN procedurally generates characters and, responding to choices made by the player, produces more responsive characters and relationships involving the player and these narrative agents. Initially, this thesis discusses other interactive narrative types that exist, such as emergent or event-driven narratives, along with their strengths and weaknesses. It then examines each aspect of PAWN, starting with initial actor generation, then moving to the capturing of game events and translating them into logical objects called Occurrences. These Occurrences are …

The Slidell Museum: Rebuilding Overlooked And Disregarded Narratives In Small-Town America, Gregory D. Scott

LSU New Orleans Theses and Dissertations

The community of Slidell, Louisiana, sits across the lake from New Orleans on the north shore of Lake Pontchartrain. Slidell quietly shrouds a multitude of fascinating historic narratives with roots that extend back to before the 1718 founding of New Orleans. The first documented European presence in the area near Slidell occurred in 1699 when Iberville camped at Goose Point a few miles west of present-day Slidell. This area would play a vital role in the survival, growth, and development of the early New Orleans settlement.

Slidell has a rich history of people, places, and events. In 2005, the devastation …

Modification, Transport, And Sources Of Hydrocarbon Oxidation Products From Groundwater At Crude Oil And Diesel Spill Sites In Minnesota: Unveiling Common “Theems” Via Spectroscopy & Chromatography, Eduardo E. Turcios Valle

LSU New Orleans Theses and Dissertations

In this thesis, petroleum-contaminated groundwater from three spill-affected Minnesota sites—two contaminated with crude oil; one with diesel—is investigated to elucidate whether differences in degradation products from different parent oils exist. After spill events, parent molecules from the leaked oil seep underground and undergo microbial degradation over time, transforming into hydrocarbon oxidation products (HOPs), water-soluble contaminants that infiltrate groundwater aquifers, flowing into nearby environments and towns while exhibiting environmental persistence, toxicity to aquatic biota, and potential risks to humans that become exposed. Spectroscopic and chromatographic study of the structural themes and spatial distributions of HOPs reveals preferential degradation of aliphatic (biolabile) …

Coenzyme Q4 Is A Functional Substitute For Coenzyme Q10 And Can Be Targeted To The Mitochondria, Laura H Steenberge, Sean Rogers, Andrew Y Sung, Jing Fan, David J Pagliarini

2020-Current year OA Pubs

Coenzyme Q10 (CoQ

Mapping Brain Function In Adults And Young Children During Naturalistic Viewing With High-Density Diffuse Optical Tomography, Kalyan Tripathy, Morgan Fogarty, Alexandra M Svoboda, Mariel L Schroeder, Sean M Rafferty, Edward J Richter, Christopher Tracy, Patricia K Mansfield, Madison Booth, Andrew K Fishell, Arefeh Sherafati, Zachary E Markow, Muriah D Wheelock, Ana María Arbeláez, Bradley L Schlaggar, Christopher D Smyser, Adam T Eggebrecht, Joseph P Culver

2020-Current year OA Pubs

Human studies of early brain development have been limited by extant neuroimaging methods. MRI scanners present logistical challenges for imaging young children, while alternative modalities like functional near-infrared spectroscopy have traditionally been limited by image quality due to sparse sampling. In addition, conventional tasks for brain mapping elicit low task engagement, high head motion, and considerable participant attrition in pediatric populations. As a result, typical and atypical developmental trajectories of processes such as language acquisition remain understudied during sensitive periods over the first years of life. We evaluate high-density diffuse optical tomography (HD-DOT) imaging combined with movie stimuli for high …

Assessment Of Illness Severity In Adults Hospitalized With Acute Respiratory Tract Infection Due To Influenza, Respiratory Syncytial Virus, Or Human Metapneumovirus, Ann R Falsey, Edward E Walsh, Stacey L House, Yannick Vandendijck, Marita Stevens, Eric K H Chan, Gabriela Ispas

2020-Current year OA Pubs

BACKGROUND: Influenza, respiratory syncytial virus (RSV), and human metapneumovirus (hMPV) are common respiratory viruses causing similar symptoms. Optimal tools to assess illness severity for these viruses have not been defined. Using the Hospitalized Acute Respiratory Tract Infection (HARTI) study data, we report symptom severity by clinician-rated clinical severity scores (CSS) in adults with influenza, RSV, or hMPV and correlations between CSS and patient-reported outcomes (PROs).

METHODS: HARTI was a global epidemiologic study in adults hospitalized with acute respiratory tract infections. Patients were assessed at enrollment within 24 h of admission with CSS and twice during hospitalization with CSS, Respiratory Infection …

Selenate-Mediated Impacts On Mercury Methylation By Pseudodesulfovibrio Mercurii With Dissolved And Nanoparticulate Mercuric Nitrate, Md Sayeduzzaman Sarker

Theses

Inorganic mercury (Hg) is converted to potential neurotoxic methylmercury (MeHg) by a natural process called Hg methylation. MeHg can be biomagnified in the food chain, thus the consumption of Hg-contaminated fish contributes to harmful human health issues. Selenium (Se) inhibits the Hg bioavailability to the methylating bacteria by forming mercuric selenide (HgSe). Pseudodesulfovibrio mercurii, a type of sulfate-reducing bacteria (SRB) cultures were grown in anaerobic environments using an estuarine sulfate lactate growth medium to evaluate the effects of Hg concentrations, bacterial growth phase, and sodium selenate in the Hg methylation process. Bacterial cultures contained two types of mercuric (II) nitrate, …

The Role Of Maternal Emotion Regulation In The Relationship Between Maternal Adverse Childhood Experiences (Aces), Negative Parenting, And Child Externalizing Behaviors, Maddison Knott

Master's Theses

Exploration of the effects of maternal Adverse Childhood Experiences (ACEs) on child externalizing behaviors were conducted in the proposed study. Subtypes of ACEs, such as household dysfunction and maltreatment, and their effects on child externalizing behaviors were also examined. Maternal ACEs have shown to have negative effects on their children through use of more negative parenting practices (NPP). However, the role of maternal difficulty in emotion regulation in the link between maternal ACEs, NPP, and child externalizing behaviors has not been previously shown in the literature. Thus, the present study aimed to examine these relations, specifically with NPP as a …

3d Analysis Of Fe-Ti Oxides And How They Affect Crystal-Plastic Deformation In Atlantis Bank, Southwest Indian Ridge, Sarah Hill

Master's Theses

This project focuses on the importance of the relationship between Fe-Ti oxide abundance and interconnectivity, and crystal-plastic deformation in Atlantis Bank, Southwest Indian Ridge by utilizing Micro-CT scanning. This was done through comparing the Micro-CT scans of 15 samples from three different Ocean Drilling Program and International Ocean Discovery Program drill holes using the Nikon NIS Advanced Research 3-D visualization program and producing plots and statistics from MATLAB. Results indicate a wide range of textures across a range of crystal-plastic fabric intensity and Fe-Ti oxide abundance. Ultimately, there was a generally positive relationship between depth, CPF intensity, and Fe-Ti oxide …

The Emerging Impacts Of Tourism On The Economy Of The Kingdom Of Saudi Arabia: A Comparative Study Of Oil And Tourism, Dania Abu Jabal

Master's Theses

Saudi Arabia was heavily dependent on oil, which caused an economic crisis due to the collapse of global oil prices. In 2016, the Saudi government launched Vision 2030 to diversify the Saudi economy and avoid dependence on oil revenues. One aim of Vision 2030 is to initiate numerous tourism initiatives to boost the tourism industry's economic impact, elevating its contribution from 3% of GDP to 10% by 2030.

This paper provides the necessary assessment to understand tourism's role and contribution to the Saudi economy and to determine whether the industry's growth is on the right track. Also, this paper also …

Disruption Of Polyunsaturated Fatty Acid Biosynthesis Drives Sting-Dependent Acute Myeloid Leukemia Cell Maturation And Death, Joice Kanefsky, Mary Basse, Judith Sokei, Orsola Di Martino, Liana Valin, Jeffrey A Magee, Francesca Ferraro, Stephen M Sykes, Et Al.

2020-Current year OA Pubs

The role of polyunsaturated fatty acid (PUFA) biosynthesis in acute myeloid leukemia (AML) remains largely undefined. A comparative expression analysis of 35 genes encoding fatty acid biosynthesis enzymes showed that fatty acid desaturase 1 (FADS1) was highly expressed across multiple AML subtypes relative to healthy controls and that elevated FADS1 expression correlates with worse overall AML patient survival. Functionally, shRNA-mediated inhibition of FADS1 reduced AML cell growth in vitro and significantly delayed leukemia onset in an AML mouse model. AML cell lines depleted of FADS1 arrested in the G1/S-phase of the cell cycle, acquired characteristics of myeloid maturation and subsequently …

Persistence And Evolution Of Pseudomonas Aeruginosa Following Initiation Of Highly Effective Modulator Therapy In Cystic Fibrosis, Catherine R. Armbruster, Yasmin K. Hilliam, Anna C. Zemke, Samar Atteih, Christopher Marshall, John Moore, Junu Koirala, Leah Krainz, Jordan R. Gaston, Stella E. Lee, Vaughn S. Cooper, Jennifer M. Bomberger

Biological Sciences Faculty Research and Publications

Today, more than 90% of people with cystic fibrosis (pwCF) are eligible for the highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy called elexacaftor/tezacaftor/ivacaftor (ETI) and its use is widespread. Given the drastic respiratory symptom improvement experienced by many post-ETI, clinical studies are already underway to reduce the number of respiratory therapies, including antibiotic regimens, that pwCF historically relied on to combat lung disease progression. Early studies suggest that bacterial burden in the lungs is reduced post-ETI, yet it is unknown how chronic Pseudomonas aeruginosa populations are impacted by ETI. We found that pwCF remain infected throughout their …

Patient Engagement In Designing, Conducting, And Disseminating Clinical Pain Research: Immpact Recommended Considerations, Simon Haroutounian, Katherine J. Holzer, Et Al.

2020-Current year OA Pubs

In the traditional clinical research model, patients are typically involved only as participants. However, there has been a shift in recent years highlighting the value and contributions that patients bring as members of the research team, across the clinical research lifecycle. It is becoming increasingly evident that to develop research that is both meaningful to people who have the targeted condition and is feasible, there are important benefits of involving patients in the planning, conduct, and dissemination of research from its earliest stages. In fact, research funders and regulatory agencies are now explicitly encouraging, and sometimes requiring, that patients are …

Preexisting Diabetes And Breast Cancer Treatment Among Low-Income Women, Bayu Begashaw Bekele, Min Lian, Chester Schmaltz, Tracy Greever-Rice, Pratibha Shrestha, Ying Liu

2020-Current year OA Pubs

IMPORTANCE: Diabetes is associated with poorer prognosis of patients with breast cancer. The association between diabetes and adjuvant therapies for breast cancer remains uncertain.

OBJECTIVE: To comprehensively examine the associations of preexisting diabetes with radiotherapy, chemotherapy, and endocrine therapy in low-income women with breast cancer.

DESIGN, SETTING, AND PARTICIPANTS: This population-based cohort study included women younger than 65 years diagnosed with nonmetastatic breast cancer from 2007 through 2015, followed up through 2016, continuously enrolled in Medicaid, and identified from the linked Missouri Cancer Registry and Medicaid claims data set. Data were analyzed from January 2022 to October 2023.

EXPOSURE: Preexisting …

Red Flag Signs And Symptoms For Patients With Early-Onset Colorectal Cancer: A Systematic Review And Meta-Analysis, Joshua Demb, Cassandra D L Fritz, Yin Cao, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Early-onset colorectal cancer (EOCRC), defined as a diagnosis at younger than age 50 years, is increasing, and so-called red flag signs and symptoms among these individuals are often missed, leading to diagnostic delays. Improved recognition of presenting signs and symptoms associated with EOCRC could facilitate more timely diagnosis and impact clinical outcomes.

OBJECTIVE: To report the frequency of presenting red flag signs and symptoms among individuals with EOCRC, to examine their association with EOCRC risk, and to measure variation in time to diagnosis from sign or symptom presentation.

DATA SOURCES: PubMed/MEDLINE, Embase, CINAHL, and Web of Science were searched …

Complement Regulation In The Eye: Implications For Age-Related Macular Degeneration, Georgia A. Wilke, Rajendra S. Apte

2020-Current year OA Pubs

Careful regulation of the complement system is critical for enabling complement proteins to titrate immune defense while also preventing collateral tissue damage from poorly controlled inflammation. In the eye, this balance between complement activity and inhibition is crucial, as a low level of basal complement activity is necessary to support ocular immune privilege, a prerequisite for maintaining vision. Dysregulated complement activation contributes to parainflammation, a low level of inflammation triggered by cellular damage that functions to reestablish homeostasis, or outright inflammation that disrupts the visual axis. Complement dysregulation has been implicated in many ocular diseases, including glaucoma, diabetic retinopathy, and …

Astrocytes As A Mechanism For Contextually-Guided Network Dynamics And Function, Lulu Gong, Fabio Pasqualetti, Thomas Papouin, Shinung Ching

2020-Current year OA Pubs

Astrocytes are a ubiquitous and enigmatic type of non-neuronal cell and are found in the brain of all vertebrates. While traditionally viewed as being supportive of neurons, it is increasingly recognized that astrocytes play a more direct and active role in brain function and neural computation. On account of their sensitivity to a host of physiological covariates and ability to modulate neuronal activity and connectivity on slower time scales, astrocytes may be particularly well poised to modulate the dynamics of neural circuits in functionally salient ways. In the current paper, we seek to capture these features via actionable abstractions within …

Deconstructing Pathological Tau By Biological Process In Early Stages Of Alzheimer Disease: A Method For Quantifying Tau Spatial Spread In Neuroimaging, Stephanie Doering, Austin Mccullough, Brian A Gordon, Charles D Chen, Nicole Mckay, Diana Hobbs, Sarah Keefe, Shaney Flores, Jalen Scott, Hunter Smith, Stephen Jarman, Kelley Jackson, Russ C Hornbeck, Beau M Ances, Chengjie Xiong, Andrew J Aschenbrenner, Jason Hassenstab, Carlos Cruchaga, Alisha Daniels, Randall J Bateman, John C Morris, Tammie L S Benzinger, Et Al.

2020-Current year OA Pubs

BACKGROUND: Neuroimaging studies often quantify tau burden in standardized brain regions to assess Alzheimer disease (AD) progression. However, this method ignores another key biological process in which tau spreads to additional brain regions. We have developed a metric for calculating the extent tau pathology has spread throughout the brain and evaluate the relationship between this metric and tau burden across early stages of AD.

METHODS: 445 cross-sectional participants (aged ≥ 50) who had MRI, amyloid PET, tau PET, and clinical testing were separated into disease-stage groups based on amyloid positivity and cognitive status (older cognitively normal control, preclinical AD, and …

Multi-Scale Cortical Bone Traits Vary In Females And Males From Two Mouse Models Of Genetic Diversity, Nicole Migotsky, Surabhi Kumar, John T Shuster, Jennifer C Coulombe, Bhavya Senwar, Adrian A Gestos, Charles R Farber, Virginia L Ferguson, Matthew J Silva

2020-Current year OA Pubs

Understanding the genetic basis of cortical bone traits can allow for the discovery of novel genes or biological pathways regulating bone health. Mice are the most widely used mammalian model for skeletal biology and allow for the quantification of traits that cannot easily be evaluated in humans, such as osteocyte lacunar morphology. The goal of our study was to investigate the effect of genetic diversity on multi-scale cortical bone traits of 3 long bones in skeletally-mature mice. We measured bone morphology, mechanical properties, material properties, lacunar morphology, and mineral composition of mouse bones from 2 populations of genetic diversity. Additionally, …

Onc201 (Dordaviprone) In Recurrent H3 K27m-Mutant Diffuse Midline Glioma, Isabel Arrillaga-Romany, Andrew Cluster, Et Al.

2020-Current year OA Pubs

PURPOSE: Histone 3 (H3) K27M-mutant diffuse midline glioma (DMG) has a dismal prognosis with no established effective therapy beyond radiation. This integrated analysis evaluated single-agent ONC201 (dordaviprone), a first-in-class imipridone, in recurrent H3 K27M-mutant DMG.

METHODS: Fifty patients (pediatric, n = 4; adult, n = 46) with recurrent H3 K27M-mutant DMG who received oral ONC201 monotherapy in four clinical trials or one expanded access protocol were included. Eligible patients had measurable disease by Response Assessment in Neuro-Oncology (RANO) high-grade glioma (HGG) criteria and performance score (PS) ≥60 and were ≥90 days from radiation; pontine and spinal tumors were ineligible. The …

Computationally Restoring The Potency Of A Clinical Antibody Against Omicron, Thomas A Desautels, Suzanne M Scheaffer, Bradley Whitener, James B Case, Larissa B Thackray, Michael S Diamond, Et Al.

2020-Current year OA Pubs

The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs