Digital Commons Network^™

Optimizing Pediatric Care: Bridging Gaps And Addressing Disparities For Children With Disabilities Or Medical Complexities Through Medication Therapy Management (Mtm), Phuongloan Hoang, Drew Mccanless, Seana-Pierre Williams, Rajat Sharma, Mariam-Sere Diaby, Lauren Callaway, Jihui Diaz

Research Day

INTRODUCTION

Children with disabilities and medical complexity require complex medication regimens that are challenging for caregivers when managing medication. We conducted a secondary meta-analysis using data from the National Health Interview Survey (NHIS) to explore medication adherence disparities based on caregivers’ socioeconomic status. Medication Therapy Management (MTM) and similar services have been shown to improve treatment adherence. We aim to investigate the utilization of MTM services among underprivileged communities by developing a structured survey for the target population and aim to examine whether caregivers’ socioeconomic status (SES) impacts medication adherence within our study cohort. Our ultimate goal is to improve …

Case Study: Lead Contamination Propagation Into Plants Of A Metro Atlanta Home, Jaci Carithers, Samantha Gowen, Mbill Khan, Gokbet Owusu-Poku, Francis Jenney

Research Day

INTRODUCTION: Lead pollution in residential areas of Metro Atlanta has spurred action from the EPA to increase efforts to remediate the contaminated soil, resulting in the designation of the Westside Lead Atlanta, GA Superfund site. Lead poses significant risks to human health, interfering with vital biological functions such as its mimicry and blocking of important calcium-dependent pathways. Contributing to this issue are the historic practices of lead-based industries with poor disposal practices, causing local soil and water pollution. This issue is evident particularly along historical railroad routes used for transporting heavy metal-laden industrial goods. The soil along these routes frequently …

What An Astronaut’S Gut Microbiome Must Feel In Space: Simulated Microgravity And Ionizing Radiation Changing Escherichia Coli’S Growth Dynamics., Parker Mann, Hugo Castillo

Discovery Day - Daytona Beach

With space travel becoming more prominent, research in microgravity conditions has been of increasing interest among many scientists. It is important that as we continue to develop a means of survivability outside of Earth’s atmosphere, we must explore every aspect of physiological health in astronauts. One important factor that is being researched is how microorganisms, such as bacteria, can influence an astronaut's immune system under microgravity conditions. Studies have shown that when astronauts travel to space, their gut microbiota changes drastically than when they are on Earth. This difference in response may be due to a specific bacteria having experienced …

Using Advocacy Exercises To Promote Academic Identity And Ownership, Timothy Schoenfeld

Faculty Scholarship Symposium

In the sciences and mathematics, having a strong STEM-related skillset and personal STEM identity are both important for fostering long-term persistence in STEM-related vocational fields. Science and math courses are routinely designed to build the skillset of students but creating a positive STEM identity is more difficult, particularly for underrepresented groups. Across the semester of a pilot neuroscience course, students engaged in daily and semester-long exercises in learning about and practicing advocacy as a way to build positive identities in science. At the beginning and end of the semester, students took the Persistence in the Sciences (PITS) survey, measuring student …

Plant And Microbial Interactions Under Simulated Lunar Conditions, Emma Costa, Parker Mann, Paulina Slick, Collin Topolski, Maria Tobarra, Hugo Castillo

Discovery Day - Daytona Beach

With the increase of research on establishing a lunar base, there are many challenges faced regarding sustainable living conditions. Some limitations include the cost of long-term spaceflight due to the frequent transport of food supply to the moon. The use of in-situ resources and the recycling of biomass waste can be used for sustainable crop production to decrease the costs of long-term spaceflight and make efficient use of payloads. Lunar regolith, the moon’s soil, contains all the nutrients needed for plant growth except for nitrogen. However, biomass waste, such as organic waste, can be used as a nitrogen source and …

Design Of A Low Cost 2dof Geartrain For Broad Applications In Quadrupedal Robots, Benjamin Labiner, David Jay

Florida Conference on Recent Advances in Robotics

This paper presents the design and analysis of a low-cost two-degree-of-freedom (2DOF) geartrain tailored for versatile applications in quadrupedal robots. Leveraging principles of simplicity and affordability, the described geartrain design aims to provide an effective solution for transferring power from motors to limbs while minimizing manufacturing costs. This paper discusses the key considerations in geartrain design, including gear ratio selection, material choice, and mechanical efficiency, highlighting the trade-offs between performance and cost. Through mathematical modeling and extensive testing, the ideal parameters of the geartrain are identified to achieve desired locomotion capabilities across various terrains and loads. This geartrain design offers …

Bioinspired Infrastructure Design: Leveraging Kinship Coefficients In Eusocial Animals For Resilient Systems, Fayruz Maysha, Bryan Watson

Discovery Day - Daytona Beach

This study introduces a novel bioinspired algorithm influenced by the kinship coefficients observed in eusocial animals, particularly honeybees (Apis mellifera). In our study, we present a novel bioinspired algorithm, taking inspiration from honeybee kinship coefficient, tailored for optimizing resource allocation in disaster scenarios. This focuses on innovative product-service and energy systems by proposing an infrastructure design that is both resilient and adaptable. By emulating the kinship coefficient observed in bees, we offer an algorithm that enhances the effectiveness of firefighting resources, underscoring the potential of bioinspired computing to revolutionize emergency management and resilience within the context of product-service systems. Our …

A New Biological Inspired Resource Allocation Algorithm For Distributed Multi Agent Systems With Limited Knowledge, Julia Gorthey

Discovery Day - Daytona Beach

Resource allocation in scenarios involving uncertainty, limited information, and potential threats can pose significant challenges and difficulties. Swarm intelligence, characterized by the cooperative dynamics of individuals, could enhance community resilience. This is particularly true for scenarios that involve the allocation of finite resources. This study examines a new biologically inspired distributed resource allocation algorithm, drawing inspiration from snapping shrimp colonies. Operating within environments with uncertainty and resource limitations, snapping shrimp colonies exhibit distributed resource allocation when they allocate a limited number of defenders to protect the nest. The hypothesis of the paper is if inspiration is drawn from the snapping …

Prevalence Of Cardiovascular Conditions After Traumatic Brain Injury: A Comparison Between The Traumatic Brain Injury Model Systems And The National Health And Nutrition Examination Survey, Shanti Pinto, Bhaskar Thakur, Raj Kumar, Amanda Rabinowitz, Ross Zafonte, William C Walker, Kan Ding, Simon Driver, Umesh Venkatesan, Gilbert Moralez, Kathleen Bell

Department of Rehabilitation Medicine Faculty Papers

BACKGROUND: The purpose of this study is to compare the prevalence of self-reported cardiovascular conditions among individuals with moderate to severe traumatic brain injury (TBI) to a propensity-matched control cohort.

METHODS AND RESULTS: A cross-sectional study described self-reported cardiovascular conditions (hypertension, congestive heart failure [CHF], myocardial infarction [MI], and stroke) from participants who completed interviews between January 2015 and March 2020 in 2 harmonized large cohort studies, the TBI Model Systems and the National Health and Nutrition Examination Survey. Mixed-effect logistic regression models were used to compare the prevalence of cardiovascular conditions after 1:1 propensity-score matching based on age, sex, …

Academic Senate - Minutes, 5/7/2024, Academic Senate

Academic Senate Minutes

No abstract provided.

Chronic Stress-Induced Neuroinflammation: Relevance Of Rodent Models To Human Disease., Abigail G White, Elias Elias, Andrea Orozco, Shivon A Robinson, Melissa T Manners

College of Science & Mathematics Departmental Research

The brain is the central organ of adaptation to stress because it perceives and determines threats that induce behavioral, physiological, and molecular responses. In humans, chronic stress manifests as an enduring consistent feeling of pressure and being overwhelmed for an extended duration. This can result in a persistent proinflammatory response in the peripheral and central nervous system (CNS), resulting in cellular, physiological, and behavioral effects. Compounding stressors may increase the risk of chronic-stress-induced inflammation, which can yield serious health consequences, including mental health disorders. This review summarizes the current knowledge surrounding the neuroinflammatory response in rodent models of chronic stress-a …

Optical Tweezers Explorations: Dna-Mitoxantrone Interactions At 20pn, Heléna Kathryn Beeloo

Honors Program Theses and Projects

Mitoxantrone is a chemotherapy drug that treats a variety of cancers by inhibiting cancer cell replication through intercalation with DNA. Intercalation is the process by which certain small molecules slide flat planar regions in their structure between the base pairs of DNA. This increases the stacking force in the DNA double helix, preventing DNA replication by increasing the force required to separate the two strands that compose the helix. In this study, dual-beam optical tweezers were used to determine the binding kinetics and dissociation constant of Mitoxantrone to single molecules of DNA at 20 pN of force. This study utilized …

Then And Now: Comparing The Representations Of Gender, Race, And Class In Rom-Coms From The 1990s To Today, Madeline Goldberg

Honors Program Theses and Projects

The formula of the romantic comedy is relatively consistent. The couple meets, they get closer, there are trials and tribulations in their relationship which lead to a confession of love, and they live happily ever after from that point on. Popularized by films such as When Harry Met Sally (1989), Sleepless in Seattle (1993), and You’ve Got Mail (1998), the rom-com genre had a modern resurgence in the 1990s led by the films of Meg Ryan, and has continued to have many moments of relevance in the decades since. Romance can be a divisive genre. People who enjoy it do …

Faculty Senate Minutes 2024-05-07 - B, The University Of Texas Rio Grande Valley. Faculty Senate.

Faculty Senate Minutes

No abstract provided.

Faculty Senate Minutes 2024-05-07 - A, The University Of Texas Rio Grande Valley. Faculty Senate.

Faculty Senate Minutes

No abstract provided.

Ud Biology Student Helps Restore Rare Butterfly Species In Local Wetlands, Lauren Mccarty

College of Arts and Sciences Newsroom

University of Dayton senior Joseph Reichel wanted to do a restoration project through the Dean’s Summer Fellowship program

Natural Reflection: Reducing The Environmental Impact Of Architecture Through Biomimetic Design, Keenan Doricent

Bachelor of Architecture Theses - 5th Year

This project studies how typical building projects contribute to our environmental issues today and possible ways to reduce that contribution moving forward. In my literature review, I discuss the potential of biomimetic design as a possible solution for more environmentally considerate architecture techniques. Building operations and the construction process are two of the leading contributors to energy consumption and our growing ecological footprint as an industry. Everything from sourcing materials, to site preparation, and ultimately building occupation, factor into the effect of a structure’s life on the environment. The embodied and operational energy use of our expanding infrastructure continues to …

The Family History Of Hannah Bogina, Hannah Bogina

Your Family in History: HIST 550/700

No abstract provided.

Complete Pathologic Response To Gemcitabine And Oxaliplatin Chemotherapy After Prior Therapies In A Patient With Hepatocellular Carcinoma And Peritoneal Metastases Undergoing Cytoreductive Surgery And Hyperthermic Intraperitoneal Chemotherapy, Amry Majeed, Sneha Alaparthi, Dina Halegoua-De Marzio, Jaime Eberle-Singh, Wei Jiang, Pramila Rani Anne, Ashesh P. Shah, Wilbur B. Bowne, Daniel Lin

Jefferson Hospital Staff Papers and Presentations

Hepatocellular carcinoma (HCC) is often diagnosed at a late stage and frequently recurs despite curative intervention, leading to poor survival outcomes. Frontline systemic therapies include combination immunotherapy regimens and tyrosine kinase inhibitors. We report a case of a 38-year-old woman with chronic hepatitis B and C coinfection-associated non-cirrhotic HCC, which recurred in the peritoneum after initial resection of her primary tumor. Disease progression occurred on both atezolizumab/bevacizumab and lenvatinib, and she was subsequently treated with gemcitabine and oxaliplatin (GEMOX) chemotherapy and exhibited a profound clinical response on imaging with normalization of alpha fetoprotein (AFP) after several months. Following extensive multidisciplinary …

The Relationship Between Ultrarunning Status, Subjective Well-Being, And Life Satisfaction, Raquel Ramirez Hernandez

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic resulted in a rise in mental health challenges across the United States. Consequently, two important well-being measures for Healthy People 2030—subjective well-being and life satisfaction—were negatively impacted. A plethora of evidence exists about the benefits of running for physical and mental health. Yet, there is no available evidence that shows the benefits of ultrarunning, subjective well-being, and life satisfaction. This quantitative cross-sectional study examined the relationship between ultrarunning status, subjective well-being, and life satisfaction among adult runners in the United States. The advanced triangle of epidemiology served as the conceptual framework. A convenience sample included 369 adult …

2024 Phi Beta Kappa Induction Ceremony Program, Phi Beta Kappa, Psi Of California Chapter At Chapman University

Phi Beta Kappa Induction Ceremony Programs

The 2024 Induction Ceremony for the Psi of Chapter California was held on May 7, 2024 at the Hilbert Museum of California Art at Chapman University. In this ceremony, 22 outstanding students were inducted into Phi Beta Kappa.

Neurobiological Underpinnings Of Autistic Traits, Sensory Processing, And Mental Health In Young Adult Males And Females, Miranda Jane Mcquarrie

Theses and Dissertations

Females may present with autism more frequently than is diagnosed, due, in part, to autistic trait and sensory processing differences. Unfortunately, recruiting enough autistic female participants is difficult, because of such underdiagnoses. By approaching autism as a continuous variable, neurotypical (NT) individuals can be studied to better understand autistic individuals. Thus, to examine potential neurobiological underpinnings of sex-based behavioral profiles, we recruited 52 NT individuals (22 male; 30 female). Participants underwent resting-state functional magnetic resonance imaging (fMRI) to examine how functional network connectivity (via group independent components analysis) underpinned overall male/female differences in previously measured behavioral autistic trait and sensory …

[Re]Mapping Resilience: Reimagining Urban Waterfronts In The Face Of Climate Change, Brandon Bernard

Bachelor of Architecture Theses - 5th Year

By the year 2100, southern-Florida is projected to experience a 1-2 meter rise in sea level, resulting in the lower portion of the state becoming almost completely submerged under a new watertable.[14] During the 19th and 20th centuries, the city of Miami developed rapidly and the community and economy inevitably became intertwined with the water and its ecology. Due to the growing population and economy, urban developments soared and led to low-lying areas being filled in, open space along waterways were claimed for commercial and residential buildings, and man-made islands such as the venetian islands were constructed. As a result, …

Updates To The Alliance Of Genome Resources Central Infrastructure., The Alliance Of Genome Resources Consortium

Faculty Research 2024

The Alliance of Genome Resources (Alliance) is an extensible coalition of knowledgebases focused on the genetics and genomics of intensively studied model organisms. The Alliance is organized as individual knowledge centers with strong connections to their research communities and a centralized software infrastructure, discussed here. Model organisms currently represented in the Alliance are budding yeast, Caenorhabditis elegans, Drosophila, zebrafish, frog, laboratory mouse, laboratory rat, and the Gene Ontology Consortium. The project is in a rapid development phase to harmonize knowledge, store it, analyze it, and present it to the community through a web portal, direct downloads, and application programming interfaces …

Human Il-6 Fosters Long-Term Engraftment Of Patient-Derived Disease-Driving Myeloma Cells In Immunodeficient Mice., Zainul S Hasanali, Alfred L Garfall, Lisa Burzenski, Leonard D. Shultz, Yan Tang, Siddhant Kadu, Neil C Sheppard, Wei Liu, Derek Dopkin, Dan T Vogl, Adam D Cohen, Adam J Waxman, Sandra P Susanibar-Adaniya, Martin Carroll, Edward A Stadtmauer, David Allman

Faculty Research 2024

Multiple myeloma is a largely incurable and life-threatening malignancy of antibody-secreting plasma cells. An effective and widely available animal model that recapitulates human myeloma and related plasma cell disorders is lacking. We show that busulfan-conditioned human IL-6-transgenic (hIL-6-transgenic) NSG (NSG+hIL6) mice reliably support the engraftment of malignant and premalignant human plasma cells, including from patients diagnosed with monoclonal gammopathy of undetermined significance, pre- and postrelapse myeloma, plasma cell leukemia, and amyloid light chain amyloidosis. Consistent with human disease, NSG+hIL6 mice engrafted with patient-derived myeloma cells developed serum M spikes, and a majority developed anemia, hypercalcemia, and/or bone lesions. Single-cell RNA …

Mouse Genome Informatics: An Integrated Knowledgebase System For The Laboratory Mouse., Richard M. Baldarelli, Cynthia Smith, Martin Ringwald, Joel E Richardson, Carol J Bult, Mouse Genome Informatics

Faculty Research 2024

Mouse Genome Informatics (MGI) is a federation of expertly curated information resources designed to support experimental and computational investigations into genetic and genomic aspects of human biology and disease using the laboratory mouse as a model system. The Mouse Genome Database (MGD) and the Gene Expression Database (GXD) are core MGI databases that share data and system architecture. MGI serves as the central community resource of integrated information about mouse genome features, variation, expression, gene function, phenotype, and human disease models acquired from peer-reviewed publications, author submissions, and major bioinformatics resources. To facilitate integration and standardization of data, biocuration scientists …

The Effects Of Gamma Glutamyl Cysteinyl Ethyl Ester On Oxidative Stress Biomarkers In Traumatically Injured Rats, Jenna Shoemaker

Honors Theses

Primary injury is the original point where the impact force affects axonal tissue. Secondary injury is often the main complication in patients suffering from traumatic brain injury (TBI). Consequences of secondary injuries include oxidative stress, DNA damage, and protein oxidation, which can impact overall brain function (Moppett). Gamma-glutamyl cysteinyl ethyl ester (GCEE), a glutathione mimetic, has been used as an antioxidant to reduce oxidative stress. This study aims to determine if GCEE is neuroprotective against moderate TBI at extended time points. Results from this work will provide insight for determining the best extended time point to administer treatment. This study …

Living Emission Abolish Filters (Leafs) For Methane Mitigation: Design And Operation, Richard Hamilton, Nicholas Griffith, Peter Salamon, Robert Handler, Marina G. Kalyuzhnaya

Michigan Tech Publications

As one of the most potent greenhouse gases, methane is a critical target for the near-term mitigation of global warming. Efficient, scalable, easy-to-implement, and robust mitigation technologies are urgently needed to assist in reaching methane abolishment. The goal of this research was to test the applicability of active, extremophilic methanotrophic cells as a baseline concept for engineered systems aiming at methane capturing. The system, named living emission abolish filters (LEAFs), represents an array of immobilized biomaterials capable of capturing methane directly from vent streams. The biomaterials were made using cells of Methylotuvimicrobium alcaliphilum 20ZR, a robust halophilic methanotrophic bacterium with …

Creative Writing And Reading For Groups: Creating With Words, Responding Without Them. A Community Intervention., Marcela Morgheinstern

Expressive Therapies Capstone Theses

This thesis explores creative writing and reading groups for therapeutic purposes from historical, research, and neuroscience perspectives. The purpose was to differentiate creative writing and reading from other writing techniques and to incorporate its resources in a community Expressive Arts Therapy intervention. The benefits of reading, writing, and groups for well-being are described. A creative writing experience as a center of an Expressive Arts Therapy intervention was planned and executed, and its description and results are included. The author advocates for the therapeutic possibilities of language when used as a creative tool.

Does Dopamine Have A Behavioral Effect On Constant Light?, Alexis Anzalone

Master’s Theses and Projects

No abstract provided.