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Articles 73831 - 73860 of 820153
Full-Text Articles in Entire DC Network
2024.05.16 - Academic/Student Affairs, Enrollment, And Technology Committee Meeting Miutes, Northeastern Illinois University Board Of Trustees
2024.05.16 - Academic/Student Affairs, Enrollment, And Technology Committee Meeting Miutes, Northeastern Illinois University Board Of Trustees
Board of Trustees - 2024
Meeting materials for the NEIU Academic/Student Affairs, Enrollment and Technology Committee
The Role Of Mating Effort And Co-Residence History In Step-Grandparental Investment, Jenni E. Pettay, David A. Coall, Mirkka Danielsbacka, Antti O. Tanskanen
The Role Of Mating Effort And Co-Residence History In Step-Grandparental Investment, Jenni E. Pettay, David A. Coall, Mirkka Danielsbacka, Antti O. Tanskanen
Research outputs 2022 to 2026
The prevalence of divorce in both parental and grandparental generations has led to a rise in the number of children who now have families that include both biological and step-grandparents. Despite the thorough examination of biological grandparents' contributions in the recent literature, there remains a scarcity of studies focusing on the investment of step-grandparents. Using population-based data from a sample of 2494 parents in Germany, we assessed grandparental investment through financial support and assistance with childcare of grandparents (N = 4238) and step-grandparents (N = 486). The study revealed that step-grandparents provided lower levels of investment in their grandchildren compared …
Antiseizure Properties Of Fenamate Nsaids Determined In Mature Human Stem-Cell Derived Neuroglial Circuits., Hamed Salmanzadeh, Robert F. Halliwell
Antiseizure Properties Of Fenamate Nsaids Determined In Mature Human Stem-Cell Derived Neuroglial Circuits., Hamed Salmanzadeh, Robert F. Halliwell
School of Pharmacy Faculty Articles
Repeated and uncontrolled seizures in epilepsy result in brain cell loss and neural inflammation. Current anticonvulsants primarily target ion channels and receptors implicated in seizure activity. Identification of neurotherapeutics that can inhibit epileptiform activity and reduce inflammation in the brain may offer significant benefits in the long-term management of epilepsy. Fenamates are unique because they are both non-steroidal anti-inflammatory drugs (NSAIDs) and highly subunit selective modulators of GABAA receptors. In the current study we have investigated the hypothesis that fenamates have antiseizure properties using mature human stem cell-derived neuro-glia cell cultures, maintained in long-term culture, and previously shown to …
Game-Based Learning: A Handbook For Chilean Elementary Efl Educators, Bernardita Maria Ramirez Larrain
Game-Based Learning: A Handbook For Chilean Elementary Efl Educators, Bernardita Maria Ramirez Larrain
Master's Projects and Capstones
English language learning in Chilean elementary schools presents a significant challenge. Despite mandatory English education since fifth grade, many students struggle to achieve high proficiency, highlighting the need for transformative interventions. The presented curricular design addresses this problem by integrating game-based activities to enhance listening and speaking skills in Chilean elementary schools. Titled "Level Up Language Learning: Transforming Chilean Elementary EFL Instruction with Game-Based Learning," the handbook offers customizable games aligned with the Chilean proposed curriculum, catering to individual learner needs and diverse learning styles. This approach aims to bridge the gap between theory and practice, empowering educators and improving …
An Investigation Of The Effect Of A Combined Physical Exercise And Counseling As A Therapeutic Approach To Reducing Anxiety Symptoms, Andrea C. Beltran
An Investigation Of The Effect Of A Combined Physical Exercise And Counseling As A Therapeutic Approach To Reducing Anxiety Symptoms, Andrea C. Beltran
Doctoral Dissertations and Projects
Mental health issues are on the rise as the increase in emotional, psychological, and social well-being affects how people think, act, or feel toward themselves and others. The topic of physical exercise and mental health services has been researched to show a strong relationship between physical activity and positive mental health outcomes. Anxiety is the most common mental health concern in the United States (Goodwin et al., 2020). This study aims to investigate and quantify the impact and explore the relationships of the combined intervention approach of physical activity and counseling in reducing symptoms of anxiety. This research will utilize …
Successful Small Business Strategies Addressing Financially Related Adverse Circumstances, Shirley Thomas
Successful Small Business Strategies Addressing Financially Related Adverse Circumstances, Shirley Thomas
Walden Dissertations and Doctoral Studies
Small businesses are a crucial part of the economy of the United States. However, once a small business owner experiences a financially related adverse circumstance, the chances of failure increase exponentially. Grounded in the rational choice theory, the purpose of this qualitative multiple case study was to identify and explore the effective strategies small business owners use when addressing financially related adverse circumstances. The participants were four small business owners in the Washington, D.C. metropolitan area who used successful strategies to address financially related adverse circumstances. Data were collected using semistructured interviews and reviews of organizational documents and analyzed using …
Unraveling Etc Complex I Function In Ferroptosis Reveals A Potential Ferroptosis-Inducing Therapeutic Strategy For Lkb1-Deficient Cancers, Chao Mao, Guang Lei, Amber Horbath, Min Wang, Zhengze Lu, Yuelong Yan, Xiaoguang Liu, Lavanya Kondiparthi, Xiong Chen, Jun Cheng, Qidong Li, Zhihao Xu, Li Zhuang, Bingliang Fang, Joseph R Marszalek, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan
Unraveling Etc Complex I Function In Ferroptosis Reveals A Potential Ferroptosis-Inducing Therapeutic Strategy For Lkb1-Deficient Cancers, Chao Mao, Guang Lei, Amber Horbath, Min Wang, Zhengze Lu, Yuelong Yan, Xiaoguang Liu, Lavanya Kondiparthi, Xiong Chen, Jun Cheng, Qidong Li, Zhihao Xu, Li Zhuang, Bingliang Fang, Joseph R Marszalek, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan
Faculty, Staff and Student Publications
The role of the mitochondrial electron transport chain (ETC) in regulating ferroptosis is not fully elucidated. Here, we reveal that pharmacological inhibition of the ETC complex I reduces ubiquinol levels while decreasing ATP levels and activating AMP-activated protein kinase (AMPK), the two effects known for their roles in promoting and suppressing ferroptosis, respectively. Consequently, the impact of complex I inhibitors on ferroptosis induced by glutathione peroxidase 4 (GPX4) inhibition is limited. The pharmacological inhibition of complex I in LKB1-AMPK-inactivated cells, or genetic ablation of complex I (which does not trigger apparent AMPK activation), abrogates the AMPK-mediated ferroptosis-suppressive effect and sensitizes …
Enhancer Switching In Cell Lineage Priming Is Linked To Erna, Brg1’S At-Hook, And Swi/Snf Recruitment, Dhurjhoti Saha, Srinivas Animireddy, Junwoo Lee, Anna Thommen, Mckenzie M Murvin, Yue Lu, J Mauro Calabrese, Blaine Bartholomew
Enhancer Switching In Cell Lineage Priming Is Linked To Erna, Brg1’S At-Hook, And Swi/Snf Recruitment, Dhurjhoti Saha, Srinivas Animireddy, Junwoo Lee, Anna Thommen, Mckenzie M Murvin, Yue Lu, J Mauro Calabrese, Blaine Bartholomew
Faculty, Staff and Student Publications
RNA transcribed from enhancers, i.e., eRNA, has been suggested to directly activate transcription by recruiting transcription factors and co-activators. Although there have been specific examples of eRNA functioning in this way, it is not clear how general this may be. We find that the AT-hook of SWI/SNF preferentially binds RNA and, as part of the esBAF complex, associates with eRNA transcribed from intronic and intergenic regions. Our data suggest that SWI/SNF is globally recruited in cis by eRNA to cell-type-specific enhancers, representative of two distinct stages that mimic early mammalian development, and not at enhancers that are shared between the …
Bridging Faith And Restoration: A Phenomenological Study Exploring Evangelical Pastors’ Experiences Ministering To Congregants With Trauma In The Greater Toronto Area, Lindsay Knox Mcvety
Bridging Faith And Restoration: A Phenomenological Study Exploring Evangelical Pastors’ Experiences Ministering To Congregants With Trauma In The Greater Toronto Area, Lindsay Knox Mcvety
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study was to understand how evangelical pastors in the Greater Toronto Area describe their experiences with discussing trauma with congregants and their experiences with trauma-informed care in the church. The theory guiding this research is Transformative Learning Theory (TLT). As discussed by Mezirow (1991), TLT explains transformation occurs by increasing knowledge by learning about topics where outdated or misinformed concepts previously existed. The main research question is, how do evangelical pastors in the Greater Toronto Area describe their experiences ministering to congregants who have experienced trauma? Further sub-questions ask, how do evangelical pastors in …
The Essence Of Christian Paideia For Career Classical Christian Educators: A Hermeneutic Phenomenology, Binnie J. King
The Essence Of Christian Paideia For Career Classical Christian Educators: A Hermeneutic Phenomenology, Binnie J. King
Doctoral Dissertations and Projects
The purpose of this hermeneutic phenomenology was to discover the essence of Christian paideia for career classical Christian educators who make daily curricular decisions at a classical Christian online academy that serves a 2nd-12th grade international student body. A qualitative research design was used to gather data on the experiences of classical Christian educational practitioners when making curricular decisions. The theory that guided this study was Mezirow’s transformational learning theory (TLT), as all manner of teaching and learning attempts transformation to a higher ideal. A hermeneutic phenomenology was employed through the interpretive framework of critical realism to discover the essence …
A Phenomenological Study Of Adult Patients With Auto-Immune Disease And Their Exposure To Adverse Childhood Experiences, Milton Louis Gonzalez
A Phenomenological Study Of Adult Patients With Auto-Immune Disease And Their Exposure To Adverse Childhood Experiences, Milton Louis Gonzalez
Doctoral Dissertations and Projects
This qualitative phenomenological study explored and described the shared experiences of individuals impacted by an autoimmune disease and their exposure to adverse childhood experiences. The theory guiding this study was Vygotsky’s social constructivist theory, utilizing Kaiser Permanente’s Adverse Childhood Experience study as a guide to create awareness amongst physicians and mental health professionals, leading them to a more holistic approach when treating patients affected by an autoimmune disease. This was a qualitative study using Husserl’s transcendental phenomenology (TPh). The data collection methods used in the study included questionnaires, individual interviews, and document analysis. These forms of data were analyzed through …
Investigating The Effects Of Male Size And Pronotal Glowspots On Female Courtship Behaviour Of The Glowspot Cockroach (Lucihormetica Verrucosa), Ella X. Whitaker, Jane Akerman, Alexander D.M. Wilson
Investigating The Effects Of Male Size And Pronotal Glowspots On Female Courtship Behaviour Of The Glowspot Cockroach (Lucihormetica Verrucosa), Ella X. Whitaker, Jane Akerman, Alexander D.M. Wilson
School of Biological and Marine Sciences
Lucihormetica verrucosa (Blattodea, Blaberidae) are highly sexually dimorphic cockroaches, with the males having two symmetrically organised ‘glowspots’ on their pronotum. The spots can range in colour from whitish-yellow to red, depending on the quantity of carotenoids in their diet. These spots auto-fluoresce when exposed to UV wavelengths, with the amount of fluorescence inversely related to the carotenoid content. The diet-dependent aspect of the pronotal spots insinuates that they are a fitness-dependent trait and thus inform sexual selection, but existing studies have not directly investigated the role of the pronotal spots in courtship behaviour. Invertebrate sexual selection is commonly informed by …
The Future Of Health Care Conscience Laws Post-Dobbs, Nadia N. Sawicki
The Future Of Health Care Conscience Laws Post-Dobbs, Nadia N. Sawicki
The Journal of Contemporary Legal Issues
The Supreme Court’s rejection of a constitutional right to choose abortion in Dobbs v. Jackson Women’s Health Organization has prompted legislatures to make significant changes to state laws. Some states have criminalized abortion in most circumstances, while others have granted patients and health care providers broader rights to choose and access abortion. Another, perhaps less-recognized, avenue for legislative change is by amending existing state conscience laws. This Article describes the avenues state legislatures might take in using conscience laws to impact abortion access in accordance with the state’s policy preferences.
Environmentally Relevant Concentrations Of Triphenyl Phosphate (Tphp) Impact Development In Zebrafish, Benjamin Schmandt, Mfon Diduff, Gabrielle Smart, Larissa M. Williams
Environmentally Relevant Concentrations Of Triphenyl Phosphate (Tphp) Impact Development In Zebrafish, Benjamin Schmandt, Mfon Diduff, Gabrielle Smart, Larissa M. Williams
All Faculty Scholarship
A common flame-retardant and plasticizer, triphenyl phosphate (TPhP) is an aryl phosphate ester found in many aquatic environments at nM concentrations. Yet, most studies interrogating its toxicity have used µM concentrations. In this study, we used the model organism zebrafish (Danio rerio) to uncover the developmental impact of nM exposures to TPhP at the phenotypic and molecular levels. At concentrations of 1.5–15 nM (0.5 µg/L–5 µg/L), chronically dosed 5dpf larvae were shorter in length and had pericardial edema phenotypes that had been previously reported for exposures in the µM range. Cardiotoxicity was observed but did not present as cardiac looping …
The Plagiarism Question Of Ai: How Teachers Have Responded To Llms In The Classroom, Anthony E. Wolf
The Plagiarism Question Of Ai: How Teachers Have Responded To Llms In The Classroom, Anthony E. Wolf
Master's Theses
This study is a phenomenology conducted in the Spring of 2024 that interviews seven educators to bridge the gap between speculation and the observable realities of the current applicability of Large Language Models (LLMs) such as ChatGPT and Google Gemini. Interviews recorded pedagogical methods, classroom policies concerning LLMs, and various methods used to detect and address the use of LLMs for plagiarism. The findings seem to imply a relationship between the applicability of LLMs to teachers’ pedagogical methods and the policies that teachers implemented. Discussion is made through the lens of critical digital pedagogy, zone of proximal development, and Paperson’s …
K-12 Teachers’ Experience With Professional Development On Implementing Intervention For Cognitive Reading Disorders And Dyslexia: A Qualitative Hermeneutic Phenomenological Study, Rosemary Balestieri
K-12 Teachers’ Experience With Professional Development On Implementing Intervention For Cognitive Reading Disorders And Dyslexia: A Qualitative Hermeneutic Phenomenological Study, Rosemary Balestieri
Doctoral Dissertations and Projects
The purpose of this phenomenological study is to understand the experiences of the 10 K-12 teacher participants who may implement instruction and interventions for students who struggle with cognitive reading disorders and dyslexia. Instruction for intervention of cognitive reading disorders at the K-12 education level was generally defined as the multisensory approach more commonly found in schools. Instructional methods of 10 teachers at the K-12 education level for cognitive reading disorders was explored by implementing the central research question (CRQ), “What are the experiences of K-12 teachers who receive professional development to provide cognitive reading instruction with interventions specific to …
Virtual Coaching, Self-Directed Learning, And The Implementation Of Evidence-Based Practices: A Single Qualitative Case Study, Elisabeth Myers
Virtual Coaching, Self-Directed Learning, And The Implementation Of Evidence-Based Practices: A Single Qualitative Case Study, Elisabeth Myers
Doctoral Dissertations and Projects
The purpose of this single instrumental case study was to understand how a virtual coaching program provides opportunities for self-directed learning during the implementation of evidence-based practices for adults at Navigator Coaching. The theory guiding this study was Deci and Ryan’s self-determination theory as conceptualizations of self-directed learning described in the literature mirror descriptions of self-determination. The central research question was: How does a virtual coaching program provide opportunities for self-directed learning during the implementation of evidence-based practices? As a single instrumental case, the setting for this study was one virtual life-coaching program in North America. The sample of participants …
An Exploration Of Divorced Professional Black Women (Pbw) Perspectives Of Mutual Submission In Marriage, Montreal D. Ravenel
An Exploration Of Divorced Professional Black Women (Pbw) Perspectives Of Mutual Submission In Marriage, Montreal D. Ravenel
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study was to examine the viewpoints of divorced Professional Black Women (PBW) on reciprocal submission in marriage. The theories that guided this study were social exchange theory, womanist theory, and equity theory. The central research question for this study was, what is the lived experience of mutual submission in the marriage of divorced professional women? In certain instances, traditional submission behaviors have been perceived as reticence, servitude, inferiority, debasement, and a show of weakness. In addition, biblical submission is recognized as subjective to the reader or practitioner. Because submission has a long history and …
Parenting Styles Of Biological Parents With And Without A History Of Childhood Trauma, Alita M. Soulsby
Parenting Styles Of Biological Parents With And Without A History Of Childhood Trauma, Alita M. Soulsby
Doctoral Dissertations and Projects
This paper details a survey examining the impact of childhood trauma on the future parenting style of biological parents. This study included 65 parents (58 Mothers, 7 Fathers) with (n=27) and without (n=38) a history of childhood trauma. Parents were surveyed using the Parental Style Measure (Kim, Zang, & Lee, 2015) and the Early Trauma Inventory-Self-Report- Short Form (Bremner 2007) to determine parenting style and whether the participant had a history of childhood trauma. Also, parents were asked to report the number of years from the resolution of the trauma until the commencement of parenting to determine if the demonstrated …
Women In The Leadership Of Church Worship Upholding And Manifesting Biblical Principles Of Their God-Given Design, Joyce Ann Walter
Women In The Leadership Of Church Worship Upholding And Manifesting Biblical Principles Of Their God-Given Design, Joyce Ann Walter
Doctoral Dissertations and Projects
Despite the existing literature and changes in church governments that promote women in leadership roles of church worship, there remains a gap that specifies the biblical feminine qualities of women in worship leadership. These specifics should clarify the manifested characteristics of those women in leadership who exhibit the biblical distinctness of their gender from that of the male gender. Historical study shows in past generations that many denominations have banned women from such leading roles because of the interpretation of Scripture pertaining to the man being the head over the woman. This stance has been changing in the 21st century …
Special Education Teacher Perspective On Implementation Of Assistive Technology Among Students With High-Incidence Disabilities, Olga Volkov
Doctoral Dissertations and Projects
The purpose of this hermeneutic phenomenological study was to describe the experiences of implementing assistive technology with students who have high-incidence disabilities for special education teachers at a large school district. The theory guiding this study was Bandura’s self-efficacy theory. Self-efficacy is one’s belief in one’s capabilities to organize a course of action to achieve a desired outcome. Self-efficacy determines how individuals think, behave, and self-motivate. Previous studies that investigated technology utilization in schools found that teachers’ self-efficacy is one of the key factors in determining and predicting technology integration. The study employed hermeneutic phenomenology as its research methodology. A …
Undergraduate Baccalaureate Nursing Student Knowledge And Attitudes Towards Neonatal And Pediatric Pain Management Practices, Jordan Lee Slowik
Undergraduate Baccalaureate Nursing Student Knowledge And Attitudes Towards Neonatal And Pediatric Pain Management Practices, Jordan Lee Slowik
Doctoral Dissertations and Projects
Research has indicated that pain management practices amongst registered nurses is inadequate across all age groups; however, it is frequently noted that children receive less analgesia in comparable situations than adult clients leading to harmful and costly consequences. There is a distinct gap in nursing educational research understanding nursing student knowledge and attitudes towards neonatal and pediatric pain management practices. Using a convenience sample from a private, Christian-based university in the southeastern United States, this study used a quasi-experimental, one-group pretest/posttest design to understand the impact of elective nursing courses on undergraduate baccalaureate nursing student knowledge and attitudes towards neonatal …
An Interpretive Phenomenological Analysis Exploring African American Women’S Perceptions Of Access To Healthcare In The Midwest, Ramona D. Benson
An Interpretive Phenomenological Analysis Exploring African American Women’S Perceptions Of Access To Healthcare In The Midwest, Ramona D. Benson
Doctoral Dissertations and Projects
The purpose of this interpretive phenomenological study was to explore access to healthcare through the lens and lived experiences of African American Women (AAW) in Midwestern towns throughout the United States. African American women and other people of low socio-economic backgrounds continue to live with poorer health outcomes than many of their counterparts African American Women experience barriers to healthcare from a unique perspective than their White counterparts. Although medical professionals endeavor to attain equal treatment among each of their patients, significant healthcare disparities are prevalent among AAW Commonly recognized ethnic stereotypes are not always intentionally supported, however, their mere …
The Impact Of Guided Doodle Note-Taking On Reading Comprehension: A Quasi-Experimental Study, Kayla L. Dewald
The Impact Of Guided Doodle Note-Taking On Reading Comprehension: A Quasi-Experimental Study, Kayla L. Dewald
Doctoral Dissertations and Projects
The purpose of this quasi-experimental nonequivalent control-group study is to determine the impact of guided doodle note-taking strategies on middle school students’ reading comprehension. The importance of this study is the impact the data makes on the best practices of teacher instruction. The sample size is 101 students set in a city district in the Southeast United States. The students vary in socioeconomic levels, with many of them falling below the poverty line and representing a wide variety of ethnicities and races. Data was collected using pre- and post-test practices. The instrument utilized was the Reading Comprehension Scale. Data were …
Brg1/Brm Inhibitor Targets Aml Stem Cells And Exerts Superior Preclinical Efficacy Combined With Bet Or Menin Inhibitor, Warren Fiskus, Jessica Piel, Mike Collins, Murphy Hentemann, Branko Cuglievan, Christopher P Mill, Christine E Birdwell, Kaberi Das, John A Davis, Hanxi Hou, Antrix Jain, Anna Malovannaya, Tapan M Kadia, Naval Daver, Koji Sasaki, Koichi Takahashi, Danielle Hammond, Patrick K Reville, Jian Wang, Sanam Loghavi, Rwik Sen, Xinjia Ruan, Xiaoping Su, Lauren B Flores, Courtney D Dinardo, Kapil N Bhalla
Brg1/Brm Inhibitor Targets Aml Stem Cells And Exerts Superior Preclinical Efficacy Combined With Bet Or Menin Inhibitor, Warren Fiskus, Jessica Piel, Mike Collins, Murphy Hentemann, Branko Cuglievan, Christopher P Mill, Christine E Birdwell, Kaberi Das, John A Davis, Hanxi Hou, Antrix Jain, Anna Malovannaya, Tapan M Kadia, Naval Daver, Koji Sasaki, Koichi Takahashi, Danielle Hammond, Patrick K Reville, Jian Wang, Sanam Loghavi, Rwik Sen, Xinjia Ruan, Xiaoping Su, Lauren B Flores, Courtney D Dinardo, Kapil N Bhalla
Faculty, Staff and Student Publications
BRG1 (SMARCA4) and BRM (SMARCA2) are the mutually exclusive core ATPases of the chromatin remodeling BAF (BRG1/BRM-associated factor) complexes. They enable transcription factors/cofactors to access enhancers/promoter and modulate gene expressions responsible for cell growth and differentiation of acute myeloid leukemia (AML) stem/progenitor cells. In AML with MLL1 rearrangement (MLL1r) or mutant NPM1 (mtNPM1), although menin inhibitor (MI) treatment induces clinical remissions, most patients either fail to respond or relapse, some harboring menin mutations. FHD-286 is an orally bioavailable, selective inhibitor of BRG1/BRM under clinical development in AML. Present studies show that FHD-286 induces differentiation and lethality in AML cells with …
Cognitive Rehabilitation Effects On Grey Matter Volume And Go-Nogo Activity In Progressive Multiple Sclerosis: Results From The Cogex Trial, Maria A Rocca, Paola Valsasina, Francesco Romanò, Nicolò Tedone, Maria Pia Amato, Giampaolo Brichetto, Vincenzo Daniele Boccia, Jeremy Chataway, Nancy D Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel A Farrell, Peter Feys, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Robert W Motl, Amber Salter, Brian M Sandroff, Anthony Feinstein, Massimo Filippi
Cognitive Rehabilitation Effects On Grey Matter Volume And Go-Nogo Activity In Progressive Multiple Sclerosis: Results From The Cogex Trial, Maria A Rocca, Paola Valsasina, Francesco Romanò, Nicolò Tedone, Maria Pia Amato, Giampaolo Brichetto, Vincenzo Daniele Boccia, Jeremy Chataway, Nancy D Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel A Farrell, Peter Feys, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Robert W Motl, Amber Salter, Brian M Sandroff, Anthony Feinstein, Massimo Filippi
School of Health Professions
Background: Research on cognitive rehabilitation (CR) and aerobic exercise (EX) to improve cognition in progressive multiple sclerosis (PMS) remains limited. CogEx trial investigated the effectiveness of CR and EX in PMS: here, we present MRI substudy volumetric and task-related functional MRI (fMRI) findings. Methods: Participants were randomised to: 'CR plus EX', ' CR plus sham EX (EX-S)', ' EX plus sham CR (CR-S)' and ' CR-S plus EX-S"and attended 12-week intervention. All subjects performed physical/cognitive assessments at baseline, week 12 and 6 months post intervention (month 9). All MRI substudy participants underwent volumetric MRI and fMRI (Go-NoGo task). Results: 104 …
Localization Of Rnas To The Mitochondria-Mechanisms And Functions, Surbhi Sharma, Furqan M Fazal
Localization Of Rnas To The Mitochondria-Mechanisms And Functions, Surbhi Sharma, Furqan M Fazal
Faculty, Staff and Students Publications
The mammalian mitochondrial proteome comprises over 1000 proteins, with the majority translated from nuclear-encoded messenger RNAs (mRNAs). Mounting evidence suggests many of these mRNAs are localized to the outer mitochondrial membrane (OMM) in a pre- or cotranslational state. Upon reaching the mitochondrial surface, these mRNAs are locally translated to produce proteins that are cotranslationally imported into mitochondria. Here, we summarize various mechanisms cells use to localize RNAs, including transfer RNAs (tRNAs), to the OMM and recent technological advancements in the field to study these processes. While most early studies in the field were carried out in yeast, recent studies reveal …
Assessing The Impact And Cost-Effectiveness Of Covid-19 Testing In Adult Social Care Homes In England, Siyu Chen
Biology and Medicine Through Mathematics Conference
No abstract provided.
Assessing The Pre- And Post-Synaptic Effects Of Opioids On Inspiratory Rhythmogenesis, Jingzhi Zhao, Diego Morandi Zerpa
Assessing The Pre- And Post-Synaptic Effects Of Opioids On Inspiratory Rhythmogenesis, Jingzhi Zhao, Diego Morandi Zerpa
Biology and Medicine Through Mathematics Conference
No abstract provided.