Digital Commons Network^™

A Review Of Image Sensors Used In Near-Infrared And Shortwave Infrared Fluorescence Imaging, Banghe Zhu, Henry Jonathan

The Brown Foundation: Institute of Molecular Medicine

To translate near-infrared (NIR) and shortwave infrared (SWIR) fluorescence imaging into the clinic, the paired imaging device needs to detect trace doses of fluorescent imaging agents. Except for the filtration scheme and excitation light source, the image sensor used will finally determine the detection limitations of NIR and SWIR fluorescence imaging systems. In this review, we investigate the current state-of-the-art image sensors used in NIR and SWIR fluorescence imaging systems and discuss the advantages and limitations of their characteristics, such as readout architecture and noise factors. Finally, the imaging performance of these image sensors is evaluated and compared.

Effect Of Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) Loss In Lung Adenocarcinoma (Luad), Marilyn G. Vallejo Alvarez

Theses and Dissertations

Lung adenocarcinoma (LUAD) is the most common form of non-small cell lung cancer in the United States and is a major cause of cancer-related mortality. Patients with LUAD experience severe pulmonary symptoms and often progress to metastatic disease. Our previous work has shown that LUAD cells downregulate lung cell identity programs across cancer progression such as genes involved in the maintenance of epithelial barrier integrity. For example, CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), a water and bicarbonate channel, is expressed in normal alveolar type 2 (AT2) cells and is downregulated in cells that give rise to LUAD. Although the loss …

Using Rapid Protein Degradation To Determine The Effect Of Runx1 Loss-Of- Function On Dna Damage Accumulation And Repair., Jackriel Pina Morales

Theses and Dissertations

Germline mutations in RUNX1 are associated with familial platelet disorder with a predisposition to myeloid malignancy (RUNX1-FPDMM), in which patients present with low platelet counts,excessive bleeding and bruising, and an increased risk of Acute Myeloid Leukemia (AML)/Myelodysplastic Syndrome (MDS) development throughout their lifetime. To understand how these loss-of-function mutations in RUNX1 drive predispose to malignancy, it is important to develop a detailed understanding of the molecular basis of RUNX1 function. While RUNX1 is a transcription factor, preliminary data from our group and work from others suggests that RUNX1 also interacts with proteins that are critical for DNA damage …

Molecular Classification And Biomarkers Of Outcome With Immunotherapy In Extensive-Stage Small-Cell Lung Cancer: Analyses Of The Caspian Phase 3 Study, Mingchao Xie, Miljenka Vuko, Jaime Rodriguez-Canales, Johannes Zimmermann, Markus Schick, Cathy O'Brien, Luis Paz-Ares, Jonathan W Goldman, Marina Chiara Garassino, Carl M Gay, John V Heymach, Haiyi Jiang, J Carl Barrett, Ross A Stewart, Zhongwu Lai, Lauren A Byers, Charles M Rudin, Yashaswi Shrestha

Faculty, Staff and Student Publications

BACKGROUND: We explored potential predictive biomarkers of immunotherapy response in patients with extensive-stage small-cell lung cancer (ES-SCLC) treated with durvalumab (D) + tremelimumab (T) + etoposide-platinum (EP), D + EP, or EP in the randomized phase 3 CASPIAN trial.

METHODS: 805 treatment-naïve patients with ES-SCLC were randomized (1:1:1) to receive D + T + EP, D + EP, or EP. The primary endpoint was overall survival (OS). Patients were required to provide an archived tumor tissue block (or ≥ 15 newly cut unstained slides) at screening, if these samples existed. After assessment for programmed cell death ligand-1 expression and tissue …

Exploring The Tradeoff Between Data Privacy And Utility With A Clinical Data Analysis Use Case, Eunyoung Im, Hyeoneui Kim, Hyungbok Lee, Xiaoqian Jiang, Ju Han Kim

Faculty, Staff and Student Publications

BACKGROUND: Securing adequate data privacy is critical for the productive utilization of data. De-identification, involving masking or replacing specific values in a dataset, could damage the dataset's utility. However, finding a reasonable balance between data privacy and utility is not straightforward. Nonetheless, few studies investigated how data de-identification efforts affect data analysis results. This study aimed to demonstrate the effect of different de-identification methods on a dataset's utility with a clinical analytic use case and assess the feasibility of finding a workable tradeoff between data privacy and utility.

METHODS: Predictive modeling of emergency department length of stay was used as …

Multiomics Analysis Of The Phlda Gene Family In Different Cancers And Their Clinical Prognostic Value, Safia Iqbal, Md Rezaul Karim, Shahnawaz Mohammad, Ramya Mathiyalagan, Md Niaj Morshed, Deok-Chun Yang, Hyocheol Bae, Esrat Jahan Rupa, Dong Uk Yang

Faculty, Staff and Student Publications

The PHLDA (pleckstrin homology-like domain family) gene family is popularly known as a potential biomarker for cancer identification, and members of the PHLDA family have become considered potentially viable targets for cancer treatments. The PHLDA gene family consists of PHLDA1, PHLDA2, and PHLDA3. The predictive significance of PHLDA genes in cancer remains unclear. To determine the role of pleckstrin as a prognostic biomarker in human cancers, we conducted a systematic multiomics investigation. Through various survival analyses, pleckstrin expression was evaluated, and their predictive significance in human tumors was discovered using a variety of online platforms. By analyzing the protein-protein interactions, …

Variant-Specific Pathophysiological Mechanisms Of Aff3 Differently Influence Transcriptome Profiles, Sissy Bassani, Jacqueline Chrast, Giovanna Ambrosini, Norine Voisin, Frédéric Schütz, Alfredo Brusco, Fabio Sirchia, Lydia Turban, Susanna Schubert, Rami Abou Jamra, Jan-Ulrich Schlump, Desiree Demille, Pinar Bayrak-Toydemir, Gary Rex Nelson, Kristen Nicole Wong, Laura Duncan, Mackenzie Mosera, Christian Gilissen, Lisenka E L M Vissers, Rolph Pfundt, Rogier Kersseboom, Hilde Yttervik, Geir Åsmund Myge Hansen, Marie Falkenberg Smeland, Kameryn M Butler, Michael J Lyons, Claudia M B Carvalho, Chaofan Zhang, James R Lupski, Lorraine Potocki, Leticia Flores-Gallegos, Rodrigo Morales-Toquero, Florence Petit, Binnaz Yalcin, Annabelle Tuttle, Houda Zghal Elloumi, Lane Mccormick, Mary Kukolich, Oliver Klaas, Judit Horvath, Marcello Scala, Michele Iacomino, Francesca Operto, Federico Zara, Karin Writzl, Aleš Maver, Maria K Haanpää, Pia Pohjola, Harri Arikka, Anneke J A Kievit, Camilla Calandrini, Christian Iseli, Nicolas Guex, Alexandre Reymond

Faculty, Staff and Students Publications

BACKGROUND: We previously described the KINSSHIP syndrome, an autosomal dominant disorder associated with intellectual disability (ID), mesomelic dysplasia and horseshoe kidney, caused by de novo variants in the degron of AFF3. Mouse knock-ins and overexpression in zebrafish provided evidence for a dominant-negative mode of action, wherein an increased level of AFF3 resulted in pathological effects.

METHODS: Evolutionary constraints suggest that other modes-of-inheritance could be at play. We challenged this hypothesis by screening ID cohorts for individuals with predicted-to-be damaging variants in AFF3. We used both animal and cellular models to assess the deleteriousness of the identified variants.

RESULTS: We identified …

Modeling And Forecasting Cyanobacterial Harmful Algal Blooms (Cyanohabs) In Lake Pontchartrain, Shekhar Mahat

LSU Master's Theses

Harmful algal blooms (HABs) frequently occur in coastal waters worldwide, adversely affecting economies, human health, aquatic ecosystems, and recreational activities. Lake Pontchartrain, an oligohaline estuary, experienced frequent HABs from 2018 to 2023. While NOAA’s NCCOS and USEPA’s CyAN currently monitor cyanobacteria harmful algal blooms (CyanoHABs) in coastal, freshwater, and riverine systems, there is a notable lack of systems monitoring phycocyanin concentrations in the lake. This thesis utilizes satellite remote sensing environmental stressors to model and predict CyanoHABs in Lake Pontchartrain using machine learning techniques. A key focus of this study is assessing the forecasting capabilities of the random forest method …

Machine Learning Models For Predicting Blood Pressure Phenotypes By Combining Multiple Polygenic Risk Scores, Yana Hrytsenko, Benjamin Shea, Michael Elgart, Nuzulul Kurniansyah, Genevieve Lyons, Alanna C Morrison, April P Carson, Bernhard Haring, Braxton D Mitchell, Bruce M Psaty, Byron C Jaeger, C Charles Gu, Charles Kooperberg, Daniel Levy, Donald Lloyd-Jones, Eunhee Choi, Jennifer A Brody, Jennifer A Smith, Jerome I Rotter, Matthew Moll, Myriam Fornage, Noah Simon, Peter Castaldi, Ramon Casanova, Ren-Hua Chung, Robert Kaplan, Ruth J F Loos, Sharon L R Kardia, Stephen S Rich, Susan Redline, Tanika Kelly, Timothy O'Connor, Wei Zhao, Wonji Kim, Xiuqing Guo, Yii-Der Ida Chen, Trans-Omics In Precision Medicine Consortium, Tamar Sofer

Faculty, Staff and Student Publications

We construct non-linear machine learning (ML) prediction models for systolic and diastolic blood pressure (SBP, DBP) using demographic and clinical variables and polygenic risk scores (PRSs). We developed a two-model ensemble, consisting of a baseline model, where prediction is based on demographic and clinical variables only, and a genetic model, where we also include PRSs. We evaluate the use of a linear versus a non-linear model at both the baseline and the genetic model levels and assess the improvement in performance when incorporating multiple PRSs. We report the ensemble model's performance as percentage variance explained (PVE) on a held-out test …

Maternal Absence Of Female Offenders Convicted Of A Violent Crime, Smarlyn Colon

Walden Dissertations and Doctoral Studies

The purpose of this qualitative interpretative phenomenological study was to explore the experiences of maternal absence of female offenders convicted of a violent crime from the perspective of violent female offenders. Two research questions were addressed: (a) how female offenders convicted of a violence offense describe their lived experiences with their mother’s absence due to incarceration and (b) how maternal absence due to incarceration feature on female offenders’ reflections of what led to their violent offending. Interpretive phenomenological analysis was used to analyze data collected from 13 participants using semi structured interviews. The results revealed four themes: (a) the mother-child …

Innovation In Bioinformatics: Recent Tools, Database And Involvement Of Artificial Intelligence, Aziz Ahmed, Mohd Shuaib, Abdulbasid Banga, Rizwan Ahmad

Indonesian Journal of Medical Chemistry and Bioinformatics

Bioinformatics has evolved in recent years into a crucial subject and a well-liked research area that is interconnected with many approaches and disciplines. The capacity of bioinformatics and its approaches to tackle challenging biological problems and promote research and development. There are various tools and database which are used in bioinformatics. AI is the capacity of a computational system to carry out various activities associated with intellectual beings and as a computer system's imitation of human intelligence processes. The bioinformatics applications with artificial intelligence have the capacity to annotate the data in the direction of logical conclusions. By combining AI …

Pan-Cancer Interrogation Of B7-H3 (Cd276) As An Actionable Therapeutic Target Across Human Malignancies, Garje Rohan, Bruno Bastos

All Publications

B7-H3 (CD276) is a transmembrane glycoprotein of the B7 immune checkpoint superfamily that has emerged as a promising therapeutic target. To better understand the applicability of B7-H3-directed therapies, we analyzed 156,791 samples comprising 50 cancer types to interrogate the clinical, genomic, transcriptomic, and immunologic correlates of B7-H3 mRNA expression. DNA (592-gene/whole-exome) and RNA (whole-transcriptome) sequencing was performed from samples submitted to Caris Life Sciences. B7-H3 high versus low expression was based on top and bottom quartiles for each cancer type. Patients' overall survival was determined from insurance claims data. Pathway analysis was performed using gene set enrichment analyses. Immune cell …

Black Women Dying To Give Life, Teresa Gray

Publications and Research

ABSTRACT

Maternal Mortality is a prevalent problem that impacts the overall health of the nation. This predicament has been touted by presidential candidates, political leaders, obstetrical leaders, midwifery, nursing and obstetrical organizations as an urgent problem that needs to be addressed. The United States has the worst maternal mortality among high-income countries. Although the impact of maternal mortality on other groups such as Whites, Asians and Hispanics must be recognized and acknowledged, this paper focuses on its impacts on Black women. Black women are disproportionately losing their lives due to pregnancy related complications more than any other group. The contributory …

Case-Based Learning In Undergraduate Orthodontic Education: A Cross Sectional Study, Asma Shafique, Asad Rehman, Shazia Ibnerasa, Rebecca Glanville, Professor Kamran Ali

Peninsula Dental School

Introduction Student centric learning approaches have been reported to be effective in introducing higher order cognitive skills required by the health professionals. However, learners’ perceptions must be constructively aligned with new learning interventions to achieve a positive impact on their learning. The aim of this study was to explore the learning experiences of undergraduate dental students with case-based learning in orthodontics. Methods A case-based learning model was introduced on orthodontic diagnosis and treatment planning for final year students on a Bachelor of Dentistry programme toward the end of their academic year. A survey was conducted to explore the perceptions and …

Protection Of The Outer Space Environment At Stake? A Legal Analysis Of The Preservation Of The Space Environment And Its Relationship With The Protection Of Human Rights In Human Space Settlements, Leonardo A. López Marcos, Anél Ferreira-Snyman

Journal of Space Law

No abstract provided.

Technological Neutrality In The Neoliberal Ethos, Gustavo Delao

The Curriculum Studies Collaborative Journal

No abstract provided.

The Effect Of A Dynamic Lighting Schedule On Neurobehavioral Performance During A 45-Day Simulated Space Mission, Leilah Grant, Brianne Kent, Shadab Rahman, Melissa St Hilaire, Crystal Kirkley, Kevin Gregory, Toni Clark, John Hanifin, Laura Barger, Charles Czeisler, George Brainard, Steven Lockley, Erin Flynn-Evans

Department of Neurology Faculty Papers

Study Objective: We previously reported that during a 45-day simulated space mission, a dynamic lighting schedule (DLS) improved circadian phase alignment and performance assessed once on selected days. This study aimed to evaluate how DLS affected performance on a 5-minute psychomotor vigilance task (PVT) administered multiple times per day on selected days.

Methods: Sixteen crewmembers (37.4 ± 6.7 years; 5F) underwent six cycles of 2 × 8-hour/night followed by 5 × 5-hour/night sleep opportunities. During the DLS (n = 8), daytime white light exposure was blue-enriched (∼6000 K; Level 1: 1079, Level 2: 76 melanopic equivalent daytime illuminance (melEDI) lux) …

K-12 Teachers' Perceptions Of Culturally Relevant Pedagogy In Ontario, Canada, Heather Banks

Walden Dissertations and Doctoral Studies

Culturally relevant pedagogy (CRP) is an approach to teaching that emphasizes students’ cultural backgrounds in classroom learning to improve student success, cultural competence, and critical consciousness in culturally diverse learners. Research highlights that using CRP in multicultural classrooms supports the engagement, learning, and achievement of culturally diverse students around the world, but less is known about how K-12 teachers’ perceptions of CRP impact the usage of this practice in their classrooms. This basic qualitative study examined K-12 teachers’ perceptions of CRP in Ontario, Canada, to address this gap in practice and determine why educators are not widely using CRP in …

Propofol Enhancement Of Slow Wave Sleep To Target The Nexus Of Geriatric Depression And Cognitive Dysfunction: Protocol For A Phase I Open Label Trial, Rachel Lynn Rios, Michael Green, S Kendall Smith, Mohammadmehdi Kafashan, Shinung Ching, Nuri B Farber, Nan Lin, Brendan P Lucey, Charles F Reynolds, Eric J Lenze, Ben Julian Agustin Palanca, Swiped Study Team

2020-Current year OA Pubs

INTRODUCTION: Late-life treatment-resistant depression (LL-TRD) is common and increases risk for accelerated ageing and cognitive decline. Impaired sleep is common in LL-TRD and is a risk factor for cognitive decline. Slow wave sleep (SWS) has been implicated in key processes including synaptic plasticity and memory. A deficiency in SWS may be a core component of depression pathophysiology. The anaesthetic propofol can induce electroencephalographic (EEG) slow waves that resemble SWS. Propofol may enhance SWS and oral antidepressant therapy, but relationships are unclear. We hypothesise that propofol infusions will enhance SWS and improve depression in older adults with LL-TRD. This hypothesis has …

A Phase-1 Trial Of Intensive Hybrid Stuttering Modification/Fluency Shaping Therapy, Jessica Smith

USF Tampa Graduate Theses and Dissertations

Purpose: The purpose of this study was to analyze changes in frequency stuttering behaviors, speech rate, and feelings/attitudes following the University of South Florida Program for Advanced Treatment of Stuttering (USF-PATS), a hybrid stuttering modification/fluency shaping program intended for teenagers and adults who stutter moderately to very severely.

Method: Baseline and post-treatment speech samples for participants (N = 3) were analyzed for speech rate and presence of stuttering behaviors (repeated movements, fixed postures, and superfluous behaviors) across conditions (monologue and reading). An abbreviated thematic analysis was completed to analyze feelings/attitudes post-treatment.

Results: Results revealed a decrease to zero and near-zero …

Dignity Of Risk And Self-Determination In The Disability Rights Movement, Sarah Broussard

Creating Change: The Online Journal of Zines about Social Movements

No abstract provided.

Sedimented For The Future: Can Technology Sustain Tradition?, Nihal Bursa

Dublin Gastronomy Symposium

Turkish coffee is unique in its brewing technique and deeply rooted in the culture developed throughout the Ottoman geography since the sixteenth century. The knowledge, skills and rituals of Turkish coffee are transmitted to new generations through observation, participation and practicing. Be it an elaborate ritual at the Ottoman court or a modest peasant pleasure, Turkish coffee requires dedicated time, manual skills and decorum. The pace of industrialization and urbanization in the twenty-first century forced people to acquire new lifestyles. This has put Turkish coffee service in jeopardy especially in public spaces. Owing to the Turkish coffee machine designed by …

I’M Conscious Of Time: Pinhole Vignettes Of Human Co-Existence In The Anthropocene, Jennie Moran

Dublin Gastronomy Symposium

This paper explores the practice of hospitality in the context of human-induced climate change. In this new and uncertain geological era, we will be required to re-examine our reciprocity with the earth and our fellow humans. We have over-farmed and over-extracted. Our voraciousness has left the soil close to exhaustion with concerns expressed that we have a finite number of harvests left. We have more mouths to feed than ever, villages are drowning under rising seas and our activities have initiated a mass extinction of the species with whom we share the earth. The grief surrounding this crisis is complex …

Differences Between Male And Female Welding Students’ Tinkering Self-Efficacy, Kjersti Decker, Michael Pate, Tyson Sorensen, Michelle S. Burrows, Katie N. Kraus, Don Edgar

Online Journal for Workforce Education and Development

Welding, agricultural mechanics and blue-collar trades have traditionally been perceived to be reserved for males, yet many females in recent years have enrolled in training programs and have entered these careers (England, 2010). In previous research, females have indicated lower levels of tinkering self-efficacy and confidence in mechanics settings (Baker & Krause, 2007). This study examined difference between male and female welding student’s perceptions of welding technology, tinkering self-efficacy, and perceptions of learning welding technology. Students were engaged in designated tinkering activities throughout the semester to promote developing tinkering abilities. Activities included but were not limited to GMAW and …

Sea Turtle Conservation At Tortuguero: A Case On How To Turn An Ecological Challenge Into A Collaborative Opportunity For Research, Education Outreach, And Business Development, Minh Q. Huynh, Jose Noguera, Roldán A. Valverde

Southwestern Business Administration Journal

This paper provides an overview of sea turtle research and conservation at Tortuguero. The conservation work began in 1950 and is still active. How did this effort to conserve sea turtles get started and how did this process help turn an ecological challenge into a global collaborative initiative? This case is not just about sea turtle conservation, but more importantly it is about approaching a complex problem from multiple perspectives and finding innovative ways to mitigate the problem. Though the focus is on sea turtles, the process, approach, and experience learned from this case can be adapted for guidance in …

Parenting Styles Of American And Filipino Mothers: Internal Family System’S Influence On Self-Leadership, Parent-Adolescent Communication, Conflict, Self-Esteem, And Depression, Maria-Sofia Paco, Gracie Cannon

School of Psychology, Family, and Community Research Conference

This abstract investigates the levels of Self-leadership among Filipino, European-American, and African-American mothers, and explores its implications for mother-daughter communication, conflict, depression, and overall self-esteem . Research has demonstrated that Filipino mothers have significantly higher mother-daughter communication and conflict compared to European-American and African-American mothers (Paco, 2007), positing a potential correlation between Filipino mothers (in the Philippines) and their Self-led nature compared to their European-American and African-American counterparts. Furthermore, this study proposes implementing Internal Family Systems (IFS) therapy as a means to enhance Self-leadership and improve mother-daughter communication and self-esteem across these three racial groups, potentially mitigating conflicts and depression. …

Lost But Not Found: Southern Appalachia, Migration Patterns, And Culinary Tourism, Ashli Q. Stokes, Wendy Atkins-Sayre

Dublin Gastronomy Symposium

Despite growing acknowledgement of the variety of cultures that developed Southern Appalachia’s cuisine, some popular food writing continues to highlight the so-called insular nature of its food, drink, and culinary festivals. Regional tourists, especially those visiting its Blue Ridge or Smoky mountains, also remain likely to experience a delimited, often problematic Scots-Irish or white-European pioneer past, including when they eat and drink. Billboards advertise the outlaw Hatfield and McCoy Dinner Show, visitors choose from moonshine tastings in dilapidated looking but new distilleries, and diners enjoy gourmet biscuits alongside gravy “flights” at trendy restaurants in Asheville, North Carolina. Appalachian Studies and …

To The Taste Of Ghurba: Diasporic Food And Oral Memories Of Tunisia In Europe, Gabriele Proglio

Dublin Gastronomy Symposium

During an oral history research on the larger European open-air market in Turin, called “Porta Palazzo,” Tunisian people replied to my questions using the Tunisian-Arab word ghurba in order to define their condition of being in diaspora. Ghurba is a specific emotion about the condition of separation and estrangement. It is used for describing the situation of being a foreigner, migrant, illegal, invisible in a land away from home. For this reason, it evokes a state of abandonment, loneliness, isolation but also it is used for yearning a reconnection and socialization with an idea of community based on memories of …

Multi-Class Emotion Classification With Xgboost Model Using Wearable Eeg Headband Data, James Khamthung, Nibhrat Lohia, Seement Srivastava

SMU Data Science Review

Electroencephalography (EEG) or brainwave signals serve as a valuable source for discerning human activities, thoughts, and emotions. This study explores the efficacy of EXtreme Gradient Boosting (XGBoost) models in sentiment classification using EEG signals, specifically those captured by the MUSE EEG headband. The MUSE device, equipped with four EEG electrodes (TP9, AF7, AF8, TP10), offers a cost-effective alternative to traditional EEG setups, which often utilize over 60 channels in laboratory-grade settings. Leveraging a dataset from previous MUSE research (Bird, J. et al., 2019), emotional states (positive, neutral, and negative) were observed in a male and a female participant, each for …

Toxic Love: Mandating Standards In Arkansas’S Domestic Violence Laws, Alia B. Reddell

Arkansas Law Review

This Comment addresses the current scheme of domestic violence statutes, highlighting the inadequate state of domestic violence remedies and the ineffective law enforcement guidelines currently in place; it argues that the Arkansas State Legislature is in need of reforming its domestic violence policies. This recommendation is three-fold and proposes that Arkansas should abandon its current discretionary regime and adopt: (1) mandatory arrest policies; (2) statutory post-arrest procedures; and (3) mandatory prosecutorial policies to effectively protect domestic violence survivors. Part I will discuss the various types of domestic violence arrest statutes. Further, this Part will briefly highlight the significance of an …