Digital Commons Network^™

Factors Associated With Incomplete Resection For Large, Locally Invasive Non-Small Cell Lung Cancer, Whitney S. Brandt, Zhizhou Yang, Brendan T. Heiden, Pamela P. Samson, Daniel Morgensztern, Saiama N. Waqar, Bryan F. Meyers, Ruben G. Nava, G. Alexander Patterson, Benjamin D. Kozower, Varun Puri

2020-Current year OA Pubs

BACKGROUND: Large, node-negative but locally invasive non-small cell lung cancer (NSCLC) is associated with increased perioperative risk but improved survival if a complete resection is obtained. Factors associated with positive margins in this population are not well-studied.

METHODS: We performed a retrospective cohort study using National Cancer Database (NCDB) for adult patients with >5 cm, clinically node-negative NSCLC with evidence of invasion of nearby structures [2006-2015]. Patients were classified as having major structure involvement (azygous vein, pulmonary artery/vein, vena cava, carina/trachea, esophagus, recurrent laryngeal/vagus nerve, heart, aorta, vertebrae) or chest wall invasion (rib pleura, chest wall, diaphragm). Our primary outcome …

Comparison Of Methods For Creating Populations Of Models By Solving Stochastic Inverse Problems, Elizabeth Epstein

Theses

Given a parametric family of models and observational data, a researcher may be faced with an inverse problem: what distribution of parameters best creates a set of models that produce the observed data? Traditionally, Markov Chain Monte Carlo (MCMC) has commonly been used as a method to solve these stochastic inverse problems. In recent years, however, Generative Adversarial Networks (GANs) have been employed. The effectiveness of Markov Chain Monte Carlo methods as compared to a conditional generative adversarial network (cGAN) when applied to a family of models produced by a system of ordinary differential equations that model viral load over …

Depressive Symptoms And Substance Use Behaviors Among Young Adults Before And During Covid-19, Sarah Chun

Clinical Psychology Dissertations

Exposure to previous public health disasters have been found to have a significant negative impact on young adult mental health. Thus, it is important to examine the effect that COVID-19 had on young adult mental health. The current study examined differences in depressive symptoms as well as frequency and impairment of substance use in two cross-sectional samples of undergraduate students, one before COVID-19 and one during COVID-19. This study also examined the moderating effects of religiosity on the association between COVID-19 status and both depressive symptoms and substance use behaviors. Participants were 898 young adults (M_age = 19.83, …

Nonlinear Classifiers For Wet-Neuromorphic Computing Using Gene Regulatory Neural Network, Adrian Ratwatte, Samitha Somathilaka, Sasitharan Balasubramaniam, Assaf A. Gilad

School of Computing: Faculty Publications

The gene regulatory network (GRN) of biological cells governs a number of key functionalities that enable them to adapt and survive through different environmental conditions. Close observation of the GRN shows that the structure and operational principles resemble an artificial neural network (ANN), which can pave the way for the development of wet-neuromorphic computing systems. Genes are integrated into gene-perceptrons with transcription factors (TFs) as input, where the TF concentration relative to half-maximal RNA concentration and gene product copy number influences transcription and translation via weighted multiplication before undergoing a nonlinear activation function. This process yields protein concentration as the …

Tribological Performance Of Ceramic On Textured Polyethylene Contact For Artificial Hip Implants, Sandhya Vaidyanathan

Theses

Revision total hip arthroplasty (rTHA) is an expensive and surgically risky procedure that is necessary in the case of a failed primary total hip arthroplasty (pTHA). The cause of failure in artificial hip joints is often rooted in the tribological performance of the bearing surfaces such as increased wear and reduced lubrication. Surface texturing is a surface modification technique which has been studied for aerospace and automotive applications and has shown promise in the biomedical field of artificial human joints in the last two decades. Several studies have been done to assess the tribological performance of introducing surface micro-textures as …

Size-Constrained Weighted Ancestors With Applications, Philip Bille, Yakov Nekrich, Solon P. Pissis

Michigan Tech Publications

The weighted ancestor problem on a rooted node-weighted tree T is a generalization of the classic predecessor problem: construct a data structure for a set of integers that supports fast predecessor queries. Both problems are known to require Ω(log log n) time for queries provided O(n poly log n) space is available, where n is the input size. The weighted ancestor problem has attracted a lot of attention by the combinatorial pattern matching community due to its direct application to suffix trees. In this formulation of the problem, the nodes are weighted by string depth. This research has culminated in …

Implication Of Artificial Intelligence On National Security For The Nigeria Security Agencies, Musa Zakari

Journal of Terrorism Studies

The study examines the implications of AI for national security in Nigeria in the field of military logistics for Nigerian security agencies. A documentary research design was utilized for the study. Document analysis of existing policies, reports, and case studies related to AI and national security in Nigeria was utilized. The study revealed that artificial intelligence (AI) has significant prospects for national security for Nigeria's security agencies. It was revealed that AI-powered technologies enable advanced surveillance capabilities, such as facial recognition and video analytics, which aid in identifying potential threats and monitoring security situations more effectively. The Air Force uses …

Historicising Domestic Terrorism And Boko Haram Insurgency In The North East, Nigeria: Issues And Trends, Adesola Sa Adesote, Adekunle Sunday Akande, John Ojo Abimbola

Journal of Terrorism Studies

Since the return to civil rule in 1999, Nigeria has been battling with series of violent agitations from various geo-political zones in the country. These violent agitations which have taken terror dimensions have contributed to national security threat. Terrorists’ attacks have resulted in the killings of hundreds of people and wanton destruction of property that worth billions of naira through bombings. The major thrust of this paper is to investigate the challenge of domestic terrorism with major emphasis on the activities of the dreaded militant Islamic sect, popularly known as Boko Haram since 2009. The paper argues that most of …

Combination Treatment Of Biochanin A And Atorvastatin Alters Mitochondrial Bioenergetics, Modulating Cell Metabolism And Inducing Cell Cycle Arrest In Pancreatic Cancer Cells, Vilas Desai, Satya Murthy Tadinada, Hoora Shaghaghi, Ross Summer, James C.K. Lai, Alok Bhushan

College of Pharmacy Faculty Papers

Background/Aim: Pancreatic cancer is an aggressive type of cancer, with a dismally low survival rate of <5%. FDA-approved drugs like gemcitabine have shown little therapeutic success, prolonging survival by a mere six months. Isoflavones, such as biochanin A and daidzein, are known to exhibit anti-cancer activity, whereas statins reportedly have anti-proliferative effects. This study investigated the effects of combination treatment of biochanin A and atorvastatin on pancreatic cancer cells.

Materials and Methods: Pancreatic cancer cells AsPC-1, PANC-1, and MIA PaCa-2 were procured from ATCC. The cell viability studies were carried out using MTT & cell count assays. Flow cytometry was used to study cell apoptosis whereas cell metabolism studies were carried out using the Seahorse Mito stress test and XF-PMP assay. The effects of treatment on cell signaling pathways & cell cycle associated proteins were investigated using western blot whereas invasiveness of cancer cells was evaluated using gelatin zymography.

Results: The combination treatment …

Plas 439: Organic Farming And Food Systems Faculty-Led Inquiry Into Reflective Scholarly Teaching Benchmark Portfolio, Christian Stephenson

UNL Faculty Course Portfolios

Organic Farming and Food Systems is a senior and graduate level course for students in the Department of Agronomy and Horticulture. This course was previously offered but has been significantly modified as I have taken on responsibility for the course. Goals for the course include student comprehension of the methods of organic and regenerative farming and the impacts of those methods on economic, environmental, and social sustainability. An additional goal is to build student competency in the evaluation of primary, secondary, and tertiary information resources and critical thinking surrounding issues in food production. Assessment for the course was through diverse …

Individual Longitudinal Changes In Dna-Methylome Identify Signatures Of Early-Life Adversity And Correlate With Later Outcome, Annabel K. Short, Ryan Weber, Noriko Kamei, Christina Wilcox Thai, Hina Arora, Ali Mortazavi, Hal S. Stern, Laura M. Glynn, Tallie Z. Baram

Psychology Faculty Articles and Research

Adverse early-life experiences (ELA) affect a majority of the world's children. Whereas the enduring impact of ELA on cognitive and emotional health is established, there are no tools to predict vulnerability to ELA consequences in an individual child. Epigenetic markers including peripheral-cell DNA-methylation profiles may encode ELA and provide predictive outcome markers, yet the interindividual variance of the human genome and rapid changes in DNA methylation in childhood pose significant challenges. Hoping to mitigate these challenges we examined the relation of several ELA dimensions to DNA methylation changes and outcome using a within-subject longitudinal design and a high methylation-change threshold. …

How African American Clergy Perceive The Cultural Relevance And Usefulness Of The Mental Health Guide For Faith Leaders, Lisa Marie Harris

Walden Dissertations and Doctoral Studies

African Americans experience mental illness at a rate similar to White individuals but are less likely to seek professional mental health care. African Americans have traditionally turned to the Black church for mental health assistance. Various organizations have created mental health resources for clergy members, with varying levels of comprehensiveness. The purpose of this basic qualitative study was to explore how African American clergy perceived the cultural relevance and usefulness of the American Psychiatric Association Foundation’s Mental Health Guide for Faith Leaders. The study was conducted using critical race theory as its theoretical framework. Four experienced clergy participated in two …

Two Genome-Wide Interaction Loci Modify The Association Of Nonsteroidal Anti-Inflammatory Drugs With Colorectal Cancer, David A Drew, Andre E Kim, Yi Lin, Conghui Qu, John Morrison, Juan Pablo Lewinger, Eric Kawaguchi, Jun Wang, Yubo Fu, Natalia Zemlianskaia, Virginia Díez-Obrero, Stephanie A Bien, Niki Dimou, Demetrius Albanes, James W Baurley, Anna H Wu, Daniel D Buchanan, John D Potter, Ross L Prentice, Sophia Harlid, Volker Arndt, Elizabeth L Barry, Sonja I Berndt, Emmanouil Bouras, Hermann Brenner, Arif Budiarto, Andrea Burnett-Hartman, Peter T Campbell, Robert Carreras-Torres, Graham Casey, Jenny Chang-Claude, David V Conti, Matthew A M Devall, Jane C Figueiredo, Stephen B Gruber, Andrea Gsur, Marc J Gunter, Tabitha A Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R Huyghe, Mark A Jenkins, Kristina M Jordahl, Anshul Kundaje, Loic Le Marchand, Li Li, Brigid M Lynch, Neil Murphy, Rami Nassir, Polly A Newcomb, Christina C Newton, Mireia Obón-Santacana, Shuji Ogino, Jennifer Ose, Rish K Pai, Julie R Palmer, Nikos Papadimitriou, Bens Pardamean, Andrew J Pellatt, Anita R Peoples, Elizabeth A Platz, Gad Rennert, Edward Ruiz-Narvaez, Lori C Sakoda, Peter C Scacheri, Stephanie L Schmit, Robert E Schoen, Mariana C Stern, Yu-Ru Su, Duncan C Thomas, Yu Tian, Konstantinos K Tsilidis, Cornelia M Ulrich, Caroline Y Um, Fränzel J B Van Duijnhoven, Bethany Van Guelpen, Emily White, Li Hsu, Victor Moreno, Ulrike Peters, Andrew T Chan, W James Gauderman

Faculty, Staff and Student Publications

Regular, long-term aspirin use may act synergistically with genetic variants, particularly those in mechanistically relevant pathways, to confer a protective effect on colorectal cancer (CRC) risk. We leveraged pooled data from 52 clinical trial, cohort, and case-control studies that included 30,806 CRC cases and 41,861 controls of European ancestry to conduct a genome-wide interaction scan between regular aspirin/nonsteroidal anti-inflammatory drug (NSAID) use and imputed genetic variants. After adjusting for multiple comparisons, we identified statistically significant interactions between regular aspirin/NSAID use and variants in 6q24.1 (top hit

Diet Quality And Resilience Through Adulthood: A Cross-Sectional Analysis Of The Well For Life Study, Sparkle Springfield-Trice, Cara Joyce, Yi-Hsuan Wu, Ann W. Hsing, Kristen Cunanan, Christopher Gardner

Biostatistics Collaborative Core: Faculty Publications and Other Works

Despite evidence suggesting the importance of psychological resilience for successful aging, little is known about the relationship between diet quality and resilience at different ages. Our study aims to examine the association between diet quality and resilience across the stages of adulthood. Using Stanfords’ WELL for Life (WELL) survey data, we conducted a cross-sectional study of diet quality, resilience, sociodemographic, perceived stress, lifestyle, and mental health factors among 6171 Bay Area adults. Diet quality was measured by the WELL Diet Score, which ranges from 0–120. A higher score indicates a better diet quality. Linear regression analysis was used to evaluate …

The Kat Module Of The Saga Complex Maintains The Oncogenic Gene Expression Program In Mycn- Amplified Neuroblastoma, Clare F Malone, Nathaniel W Mabe, Alexandra B Forman, Gabriela Alexe, Kathleen L Engel, Ying-Jiun C Chen, Melinda Soeung, Silvi Salhotra, Allen Basanthakumar, Bin Liu, Sharon Y R Dent, Kimberly Stegmaier

Faculty, Staff and Student Publications

Pediatric cancers are frequently driven by genomic alterations that result in aberrant transcription factor activity. Here, we used functional genomic screens to identify multiple genes within the transcriptional coactivator Spt-Ada-Gcn5-acetyltransferase (SAGA) complex as selective dependencies for MYCN-amplified neuroblastoma, a disease of dysregulated development driven by an aberrant oncogenic transcriptional program. We characterized the DNA recruitment sites of the SAGA complex in neuroblastoma and the consequences of loss of SAGA complex lysine acetyltransferase (KAT) activity on histone acetylation and gene expression. We demonstrate that loss of SAGA complex KAT activity is associated with reduced MYCN binding on chromatin, suppression of …

Using Patient-Specific 3d Modeling And Simulations To Optimize Microwave Ablation Therapy For Liver Cancer, Amirreza Heshmat, Caleb S O'Connor, Jessica Albuquerque Marques Silva, Iwan Paolucci, Aaron Kyle Jones, Bruno C Odisio, Kristy K Brock

Faculty, Staff and Student Publications

Microwave ablation (MWA) of liver tumors presents challenges like under- and over-ablation, potentially leading to inadequate tumor destruction and damage to healthy tissue. This study aims to develop personalized three-dimensional (3D) models to simulate MWA for liver tumors, incorporating patient-specific characteristics. The primary objective is to validate the predicted ablation zones compared to clinical outcomes, offering insights into MWA before therapy to facilitate accurate treatment planning. Contrast-enhanced CT images from three patients were used to create 3D models. The simulations used coupled electromagnetic wave propagation and bioheat transfer to estimate the temperature distribution, predicting tumor destruction and ablation margins. The …

Nivolumab Plus Relatlimab In Patients With Previously Treated Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase Ii Checkmate 142 Study, Michael J Overman, Fabio Gelsomino, Massimo Aglietta, Mark Wong, Maria Luisa Limon Miron, Gregory Leonard, Pilar García-Alfonso, Andrew G Hill, Antonio Cubillo Gracian, Eric Van Cutsem, Bassel El-Rayes, Stephen M Mccraith, Beilei He, Ming Lei, Sara Lonardi

Faculty, Staff and Student Publications

BACKGROUND: Programmed death-1 (PD-1) inhibitors, including nivolumab, have demonstrated long-term survival benefit in previously treated patients with microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) metastatic colorectal cancer (CRC). PD-1 and lymphocyte-activation gene 3 (LAG-3) are distinct immune checkpoints that are often co-expressed on tumor-infiltrating lymphocytes and contribute to tumor-mediated T-cell dysfunction. Relatlimab is a LAG-3 inhibitor that has demonstrated efficacy in combination with nivolumab in patients with melanoma. Here, we present the results from patients with MSI-H/dMMR metastatic CRC treated with nivolumab plus relatlimab in the CheckMate 142 study.

METHODS: In this open-label, phase II study, previously treated patients with MSI-H/dMMR metastatic CRC …

Building Agency Through Sensemaking: The Transformational Journey And Identity Development Process Of Working Mother Leaders During The Covid-19 Pandemic, Lynn Levis

Dissertations

Working mothers in America have long juggled a multitude of responsibilities while navigating several systemic barriers in the very society that claims to support them. The COVID-19 pandemic had an outsized impact on mothers when children were sent home from daycares and schools to reduce the spread of the virus. This study sought to address an important gap in the literature by using a mixed methods constructivist grounded theory approach to examine how working mothers in leadership positions navigated their various roles and systems during the COVID-19 pandemic. Data collection consisted of a survey with 105 respondents, followed by individual, …

Biased Representation Of Digital Feminist Activism: A Critical Look At Cyberfeminism, Muria Endah Sokowati, Sitti Amar Azizyah Puthe Taliu

Social Transformations Journal of the Global South

The development of technology facilitated by computer networks creates ambiguity over women’s empowerment. On the one hand, the intersection of technology and women’s freedom of expression has led to the emergence of cyberfeminism. The participatory culture encourages the growth of feminist movements to facilitate public engagement and empowerment. However, several overlooked challenges persist in the representation of women’s concerns. Consequently, we undertook this study to offer critique and contemplation on digital feminist activity. This study presents a contradictory perspective, providing a counterbalance and an alternative narrative to the prevailing emphasis of previous research on the glorification of cyberfeminism and activism …

Narratives Of Utang Na Loob Among Working Panganays In The Southern Philippines, Mary Therese C. Lasanas, Kayle Erika Shayne P. Nayal, Grace Lou Marie C. Meneses, John Gabriel A. Lasquites, Nicole Rey S. Balverde, Luel Mae Z. Pilayre-Contreras, Jason O. Manaois

Social Transformations Journal of the Global South

Filipino family dynamics and culture may influence how traditional values like “utang na loob” (debt of gratitude) are understood across time. The purpose of the study is to understand the concept of utang na loob in the Southern Philippines from the perspective of working panganays (eldest children). The research investigated the narratives of the eldest child in the Filipino family regarding their experiences with utang na loob. It employed Murray’s three levels of narrative analysis as a framework and elicited themes on personal, positional, and ideological levels. Results revealed personal experiences of early maturity and filial pressure, gratitude, and fulfillment, …

Assessing Undergraduate Kinesiology Students Perspectives On The Effectiveness Of Dei Initiatives: Implications For Career Readiness And Program Development, Wakpor Rengel

Doctorate in Kinesiology

This dissertation evaluates the effectiveness of Diversity, Equity, and Inclusion (DEI) initiatives within undergraduate Kinesiology programs and their impact on students' career readiness. The study utilized a mixed-methods approach, combining quantitative data from student surveys with qualitative open-ended probes to explore perceptions and attitudes towards DEI initiatives. Findings reveal that while students recognize the importance of DEI in educational settings, there is a discrepancy between the perceived implementation of these initiatives and their effectiveness in preparing students for diverse workplaces. The research highlights the need for more integrated and practical DEI strategies in Kinesiology curricula to enhance student preparedness for …

Presynaptic Nanoscale Components Of Retrograde Synaptic Signaling, Benjámin Barti, Barna Dudok, Kata Kenesei, Miklós Zöldi, Vivien Miczán, Gyula Y Balla, Diana Zala, Mariana Tasso, Claudia Sagheddu, Máté Kisfali, Blanka Tóth, Marco Ledri, E Sylvester Vizi, Miriam Melis, László Barna, Zsolt Lenkei, Iván Soltész, István Katona

Faculty, Staff and Students Publications

While our understanding of the nanoscale architecture of anterograde synaptic transmission is rapidly expanding, the qualitative and quantitative molecular principles underlying distinct mechanisms of retrograde synaptic communication remain elusive. We show that a particular form of tonic cannabinoid signaling is essential for setting target cell–dependent synaptic variability. It does not require the activity of the two major endocannabinoid-producing enzymes. Instead, by developing a workflow for physiological, anatomical, and molecular measurements at the same unitary synapse, we demonstrate that the nanoscale stoichiometric ratio of type 1 cannabinoid receptors (CB1Rs) to the release machinery is sufficient to predict synapse-specific release probability. Accordingly, …

Multifactoral Immune Modulation Potentiates Durable Remission In Multiple Models Of Aggressive Malignancy, Matthew M Halpert, Briana A Burns, Spencer R Rosario, Henry G Withers, Akshar J Trivedi, Colby J Hofferek, Benjamin D Gephart, Haotong Wang, Jonathan Vazquez-Perez, Sharon B Amanya, Sean T Hyslop, Jianhua Yang, Jan O Kemnade, Vlad C Sandulache, Vanaja Konduri, William K Decker

Faculty, Staff and Students Publications

Tumors typically lack canonical danger signals required to activate adaptive immunity and also frequently employ substantial immunomodulatory mechanisms that downregulate adaptive responses and contribute to escape from immune surveillance. Given the variety of mechanisms involved in shielding tumors from immune recognition, it is not surprising that single-agent immunomodulatory approaches have been largely unsuccessful in generating durable antitumor responses. Here we report a unique combination of immunomodulatory and cytostatic agents that recondition the tumor microenvironment and eliminate complex and/or poor-prognosis tumor types including the non-immunogenic 4T-1 model of TNBC, the aggressive MOC-2 model of HNSCC, and the high-risk MYCN-amplified model of …

Comparative Analysis Of Doxycycline And Ayurvedic Herbs To Target Metastatic Breast Cancer: An In-Silico Approach, Acharya Balkrishna, Rashmi Mittal, Rohan Malik, Hariom Verma, Kuldeep Singh Mehra, Hariom Chaturvedi, Okeshwar Okeshwar, Swami Ishdev, Ajay Kumar, Vedpriya Arya

BioMedicine

Background: Metastasis of breast cancer cells to distant sites including lungs, liver, lymph node, brain and many more have substantially affected the overall survival outcome and distant metastasis free survival rate amongst the diseased individuals. Several pre-clinical and clinical studies were carried out to determine the potency of vigorous inhibitors but they extensively deteriorated the patient’s quality of life. Hence, there exists an urgent need to explore potent natural remedy to fight against metastatic breast cancer.

Methods: Ayurvedic medicinal plants documented in literature for their ability to fight against breast cancer was screened and their respective active moieties were evaluated …

In Vitro And In Silico Evaluation Of Andrographis Paniculata Ethanolic Crude Extracts On 3 Fatty Acid Synthase Expression On Breast Cancer Cells, Nur Amanina Johari, Nur Anisa Sapi’I, Alvin Lu Jiunn Hieng, Nurriza Ab Latif, Syazwani Itri Amran, Rosnani Hasham, Khairunadwa Jemon

BioMedicine

Background Fatty acid synthase (FASN), a key rate-limiting enzyme in the fatty acid biosynthesis pathway has been identified to be overexpressed in breast cancer. This overexpression has been affiliated with poor prognosis and resistance to chemotherapeutics. Consequently, FASN has come into focus as an appealing potential target for breast cancer treatment. Available FASN inhibitors, however, are unstable and have been correlated with adverse side effects. Objective This present study aims to investigate the potential of Andrographis paniculata ethanolic crude extract (AP) as a potent FASN inhibitor in breast cancer cells. Materials & Methods This study used MTT assay and flow …

Zinc Oxide Nanoparticles-Doped Curcumin-Assisted Recovery Of Rheumatoid Arthritis And Antioxidant Status In Experimental Rabbits, Shanza Azeez, Mishal Fatima, Ouz Gul, Huzaifa Rehman, Muhammad Aslam Shad, Haq Nawaz

BioMedicine

Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and synovial joint destruction.

Aims: The current study investigated the possible beneficial effect of zinc oxide nanoparticles-doped curcumin (ZnONPs-DC) on the recovery of RA and antioxidant status of experimental rabbits.

Methods: RA was induced in experimental rabbits by injecting complete Freund's adjuvant and collagen type-II emulsion (100 µL/kg body weight) in the base of their tail. Arthritic rabbits were orally treated with ZnONPs, curcumin, and ZnONPs-DC (250 µL/kg body weight). Serum samples from the control and study groups were collected before and after RA induction and after treatment. …

Glutaminase - A Potential Target For Cancer Treatment, Josephine Anthony, Sureka Varalakshmi, Ashok Kumar Sekar, Nalini Devarajan, Balamurugan Janakiraman, Rajendran Peramaiyan

BioMedicine

The overexpression of glutaminase is reported to influence cancer growth and metastasis through glutaminolysis. Upregulation of glutamine catabolism is recently recognized as a critical feature of cancer, and cancer cells are observed to reprogram glutamine metabolism to maintain its survival and proliferation. Special focus is given on the glutaminase isoform, GLS1 (kidney type glutaminase), as the other isoform GLS2 (Liver type glutaminase) acts as a tumour suppressor in some conditions. Glutaminolysis linked with autophagy, which is mediated via mTORC1, also serves as a promising target for cancer therapy. Glutamine also plays a vital role in maintaining redox homeostasis. Inhibition of …

Unveiling The Power Of Flavonoids: A Dynamic Exploration Of Their Impact On Cancer Through Matrix Metalloproteinases Regulation, Peramaiyan Rajendran

BioMedicine

Cancer is a prominent contributor to mortality rates globally, with its progression and spread being the primary factors underlying this assertion. Despite advancements in cancer therapy, the existing therapeutic strategies are rendered useless as a result of their toxicity and the development of chemoresistance. Hence, it is imperative to assess alternate therapy modalities, and natural compounds present a promising prospect due to their demonstrated anticancer capabilities in several research models. This article provides an overview of the regulatory mechanisms involved in the expression of metalloproteinases (MMPs) and explores the potential therapeutic function of flavonoids as agents with anticancer activity that …

Phytochemical Composition Of Clinacanthus Nutans Based On Factors Of Environment, Genetics And Postharvest Processes: A Review, Nurul Hamizah Sabindo, Rusidah Mat Yatim, Kannan Thirumulu Ponnuraj

BioMedicine

Herpes simplex, varicella-zoster lesions, skin rashes, diabetes, snake bites and insect bites have all been treated by using Clinacanthus nutans (C. nutans). The pharmacological effects of C. nutans are influenced by the presence of terpenoids, flavonoids, alkaloids, phenolic acids, saponins, glycosides, steroids and tannins. This review focused on the phytochemical makeup, which varies geographically and is a subject of scarcely existing knowledge. C. nutans served as the primary search term, while the keywords “phytochemicals”, “chemical component” and “phytochemistry” were used to search the literature in the Google Scholar, PubMed, Scopus and Web of Science databases. The articles pertinent to the …

A View On Climate Change And Its Impact On The Mediterranean Fisheries, Evelyn Ragheb

Blue Economy

Fisheries in the Mediterranean Sea are multi-specific and multi-fleet; the artisanal or small-scale fisheries, the trawling fisheries, and the seining fisheries. Currently, the Mediterranean Sea is a hotspot of climate changes. The climate change is a global phenomenon affecting the whole world, its impact is different with regions, and is affected by uncertainty. In marine waters, three climatic changes are the most important: warming, acidification and oxygen loss (deoxygenation). There are many observed impacts (positive or negative impacts) on the different regions of the Mediterranean coastal waters, and many regional models are used to predict the implication of the climate …