Digital Commons Network^™

Leadership In Extreme Contexts: An Emerging Typology, Ashley Williams

Electronic Theses and Dissertations

This study investigates the relationship between leadership and extreme contexts through the lens of rural hospitals facing environmental jolts. Rural hospitals offer a unique setting for this research, given their inherent geographic isolation, lack of resources, and the critical role these facilities play in their communities. Through a qualitative analysis of interviews with Chief Executive Officers of rural hospitals, this research takes a grounded approach to build theory surrounding how leadership not only shapes but is shaped by extreme contexts and environmental jolts. The research results in four primary contributions. Namely, this study extends existing typologies on leadership in extreme …

The Effects Of Covid-19 On Asian American Perception Of Mental Health, Emily Tseung

Electronic Theses and Dissertations

This study describes a qualitative study using a grounded theory, constructivist approach, which sampled (N = 6) Asian American college students who lived in the United States during the peak of the COVID-19 pandemic. Research shows that COVID significantly impacted the Asian American perception of mental health, including mental health help- seeking behaviors and discrimination experienced. The long-term effects of this are still largely unknown. In depth, semi-structured interviews were used to explore the lived experiences of these Asian Americans. Qualitative analysis revealed thematic differences for the following themes: (a) experience with mental illness, (b) mental health help- seeking …

An Exploration Of Rural Advanced Placement Differentiation, Kristin M. Shapiro

Electronic Theses and Dissertations

Advanced Placement classes are introductory college courses taught in high school. Over 60% of all secondary gifted programs report utilizing AP classes as part of their program offerings (Callahan et al., 2017). Despite the prevalence of AP courses, there is no exact match between this particular type of programming and the needs of gifted learners (Gallagher, 2008). The use and occurrence of AP programs across the United States have not been equal, with subsequent underrepresentation of underserved groups, including rural students (Gagnon & Mattingly, 2016) in AP classes. Rural gifted students benefit from all the same classroom differentiation techniques that …

Artificial Intelligence And Its Impact On Secondary Students' Learning, Breanna Totzke

Graduate Teacher Education

The existence of artificial intelligence (AI) and its gradual incorporation into education has started to leave a mark on pedagogy. There have been various perceptions of how AI affects students and their academic achievement. This capstone project aimed to synthesize multiple current research studies to determine how students and teachers perceived and used artificial intelligence in education (AIED) and how it benefited secondary students' learning potential. As a result of this research, the examined studies revealed that student and teacher perceptions of AI and AIED affected people's willingness to use AI (Chai et al., 2021; Cong-Lem et al., 2024; Mabuan, …

Changing The Narrative: Student Empowerment In Unequal School Contexts, Stephanie A. Nisle-Mikos

Electronic Theses and Dissertations

Educational experiences affect a wide variety of life outcomes for individuals. The type of education an individual receives influences their occupation, the neighborhood in which they live, and even their risk of mortality (National Research Council, 2013; Sasson, 2016). In particular, the life trajectories of students who attend high-poverty schools are not the same as youth who attend schools with greater resources (National Center for Education Statistics [NCES], 2013; Taylor, 2005). In this dissertation, I provide a brief background on current rates of disproportionality in education and examine how specific theoretical constructs and educational policies may be used to explain …

Mutating Lysine 336 In Msh6 Does Not Appear To Affect Dna Mismatch Repair In Saccharomyces Cerevisiae, Anthony Thompson, Daniel Reese, Noa Bennafield, Kalila Daveron, Christopher Bolden, Joanna E. Haye-Bertolozzi

XULAneXUS

Defects in the DNA mismatch repair process results in the accumulation of mutations and disease. Mutations in MSH6 and MSH2, encoding for the subunits of the MutSα complex, are often responsible for Constitutional Mismatch Repair Deficiency (CMMRD) and Lynch Syndrome (LS), respectively. This work focused on DNA mismatch repair through analysis of the MSH6 missense variant msh6-K336T. The mutation examined in this study is msh6-K336T in Saccharomyces cerevisiae, which is equivalent to msh6-K431T in humans. The mutation results in the replacement of lysine with threonine, an amino acid with different properties. It was therefore hypothesized that the mutation …

Cytotoxicity, Antibacterial And Anti-Inflammatory Properties Of A Synthesized Curcumin Analog And One Of Its Novel Derivatives, Marian Amir

Theses and Dissertations

This research aims to describe the synthesis, characterization, and the biological response via investigating the cytotoxic activity, hypoxic microenvironment response, antibacterial, and anti-inflammatory properties of the novel curcumin analog H-4073 and its succinate derivative (H-4073 SuD) in the context of hepatocellular carcinoma (HCC). The study also aimed to compare the effects of H-4073 and H-4073 SuD to assess their relative efficacy and potential as therapeutic agents. First, the cytotoxic effects of H-4073 and H-4073 SuD were evaluated on HEPG2 cell lines under normal conditions. Results revealed that H-4073 exhibited a significantly better cytotoxic effect than H-4073 SuD in normoxia. However, …

Aging-Related Changes In The Mechanical Properties Of Single Cells, Amarnath Singam, Chandrabali Bhattacharya, Seungman Park

Mechanical Engineering Faculty Research

Mechanical properties, along with biochemical and molecular properties, play crucial roles in governing cellular function and homeostasis. Cellular mechanics are influenced by various factors, including physiological and pathological states, making them potential biomarkers for diseases and aging. While several methods such as AFM, particle-tracking microrheology, optical tweezers/stretching, magnetic tweezers/twisting cytometry, microfluidics, and micropipette aspiration have been widely utilized to measure the mechanical properties of single cells, our understanding of how aging affects these properties remains limited. To fill this knowledge gap, we provide a brief overview of the commonly used methods to measure single-cell mechanical properties. We then delve into …

Characterization Of Oxidized Tau Protein Aggregation And Inhibition Of Tau Aggregation Via Map2, Brad Krzesinski

Electronic Theses and Dissertations

Neurofibrillary tangles (NFT) composed of the microtubule stabilizing protein Tau are a pathological hallmark of Alzheimer's disease (AD) and many other dementia related diseases specified as Tauopathies. Due to alternative mRNA splicing, intrinsically disordered Tau exists as six separate isoforms in the adult human brain where they are categorized by the lack or inclusion of the second repeat in the microtubule binding domain (3R or 4R respectively). Isoforms are subcategorized by the inclusion or lack thereof, one or two N-terminal inserts. Many studies show that Tau aggregates into amyloid fibrils and these fibrils can break into small oligomeric units known …

Mixing Trembling Aspen And White Spruce Increases The Understory Vegetation Cover And Improves Soil Properties But Effects Vary With Broadleaf Density, Mostarin Ara, Bradley D. Pinno, Philip G. Comeau

Aspen Bibliography

Despite the importance of species mixtures to ecosystem-based forest management, density effect of broadleaf trees in the mixture on understory vegetation and soil properties are poorly understood. In this study, we examine the effects of trembling aspen [aspen] (Populus tremuloides Michx.) -white spruce [ spruce] (Picea glauca (Moench) Vos) mixtures that vary in the proportion of aspen on understory vegetation cover, soil nutrient supply rates, and soil properties. Data were collected from an established study located in Alberta, Canada at age 20 and included the following treatments: 1. Natural regeneration of pure aspen; 2. Retaining only …

Determining The Impact Of A Diabetes Logbook In Improving Self-Care Among African Americans With Type 2 Diabetes, Winifred Moore

Doctor of Nursing Practice Projects

Type 2 diabetes is a prevalent chronic disorder that is associated with defects in the metabolism of glucose. The management of type 2 diabetes depends on patients’ adherence to self-care activities. However, patients at the project site reported poor glycemic control, which increased their risk of diabetes complications. The purpose of this quality improvement project was to educate nursing staff on the use of diabetes logbooks to improve self-care among African Americans with type 2 diabetes and thereafter have the nursing staff educate diabetic patients. A quasi-experimental pre-post-intervention design involving 30 African American adults (mean age 43.70 years) with uncontrolled …

Hepatic Lrp-1 Plays An Important Role In Amyloidosis In Alzheimer's Disease Mice: Potential Role In Chronic Heavy Alcohol Feeding, Devaraj V. Chandrashekar, G. Chuli Roules, Nataraj Jagadeesan, Urvashi R. Panchal, Adenike Oyegbesan, Oghenetega E. Imiruaye, Hai Zhang, Jerome Garcia, Kamaljit Kaur, Sanda Win, Tin A. Than, Neil Kaplowitz, Moom R. Roosan, Derick Han, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Background

Methods

A Thematic Analysis Of Parenting Experiences Of Women In Prison, Pious Maedzenge, Dawn Beichner-Thomas

Qualitative Criminology (QC)

Although there is growing literature examining system-involved mothers, little is known about their parenting experiences and coping mechanisms. Using Braun and colleagues’ (2006; 2022) reflexive thematic analysis approach, this qualitative study examines the parenting experiences of forty-four mothers incarcerated in a Midwestern correctional center. The data were gathered from interviews with incarcerated mothers and included accounts of the women’s experiences before and during their incarceration. The narratives illustrate how background experiences (i.e., sexual and physical abuse, drug dependency, and childhood experiences) shape women’s experiences of mothering, perceptions of the effects of incarceration on their children, and reentry plans. Results from …

Spatial Analysis Of Transgender And Gender Diverse Students’ Mental Health And School Board Policies In Colorado And Montana, Elizabeth Heiny

Geography and the Environment: Graduate Student Capstones

As the number of policies impacting transgender and gender diverse (TGD) people increase among school boards, understanding the impacts these policies have on mental health is important. These policies can be positive or negative. Using geographic information systems (GIS) to analyze where better mental health and TGD impacting policies are correlated can offer clear results on where students mental health is affected by these policies in Colorado and Montana. This study found that TGD impacting policies did not explain the majority of variation in mental health index score. Positive or negative correlations between the mental health index and policy positivity …

Gis-Based Dashboard For Data Analysis And Visualization At The Water Hub In Franschhoek, South Africa, Liliana Rosa Simon

Geography and the Environment: Graduate Student Capstones

This capstone project analyzes the land use change in the Franschhoek Valley, South Africa, and implements this information into an ArcGIS Experience Builder Dashboard. The development of an ArcGIS Experience Builder is utilized as a tool for improved spatial data communication at The Water Hub. An increase in urban development in the informal settlement upstream of the Stiebeuel River in the catchment basin north of the Water Hub research institute is found. The capstone uses geographic information systems, remote sensing, and ArcGIS Experience Builder to integrate spatial data into the Water Hub’s standard operating procedures. It highlights the importance of …

Gulf Of Alaska Limitations Report, Brett Watson, Noah Burke

ISER Reports

Executive Summary The purpose of this report is to document economic and demographic changes for communities of the Gulf of Alaska, Southcentral Alaska, and Southeast Alaska over the period of 1950 to 2023. Over this period several major changes were made to the way that State and Federal commercial fisheries were managed in Alaska waters. These changes -particularly the introduction of the Limited Entry program in the mid-1970s and individual fishing quotas in the mid-1990’s - limited access to fisheries. Changes to fisheries access has implications not just for the fisherman directly included or excluded, but also more broadly to …

Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, Youssef Mohamed Kotb

Theses and Dissertations

Implantable drug delivery devices have many benefits over traditional drug administration techniques and have attracted a lot of attention in recent years. By delivering the medication directly to the tissue, they enable the use of larger localized concentrations, enhancing the efficacy of the treatment. Passive-release drug delivery systems, one of the various ways to provide medication, are great inventions. However, they cannot dispense the medication on demand since they are nonprogrammable. Therefore, active actuators are more advantageous in delivery applications. Smart material actuators, however, have greatly increased in popularity for manufacturing wearable and implantable micropumps due to their high energy …

Attrition And Assimilation: The Neural Mechanisms Of Mandarin-English Bilingualism, Natalie Paige Robison

University Honors Theses

This line of research investigates attrition of native language (L1) Mandarin proficiency with increasing proficiency in English. English uses pitch to denote intonation (e.g., "it's there?" versus "it's there!"), while Mandarin additionally uses pitch to indicate word meanings; e.g., /he/ means "drink" when spoken with a high, level tone, or "river" when spoken with a rising tone. The present study delineates between two alternative explanations for the prior finding that English proficiency correlates with attrition of Mandarin tones, but not Mandarin vowels. This pattern could be explained by 1) assimilability of the Mandarin vowel contrasts used in the study into …

Deciphering The Microbial Fingerprint Of Covid-19: A Multi-Layered Exploration Of The Oral And Gut Microbiome Dysbiosis, Iman Mostafa Sultan

Theses and Dissertations

The impact of SARS-CoV-2 infection on the human microbiome remains a dynamic and intricate puzzle. This study delves deeper into this mystery by revisiting the oral and gut microbial compositions of 53 COVID-19 patients before and after viral clearance, alongside comparisons to 76 healthy individuals. Through a comparative lens, we have emploed two distinct differential abundance methods – DeSeq2 and ANCOM – while drawing upon the thorough SILVA database encompassing the full-length 16S rRNA gene. The analysis underscores the crucial role of a diverse methodological choir in microbiome research. In certain instances, the congruence between DeSeq2 and ANCOM may exhibit …

Investigating The Regulation Of The Hypothalamic-Pituitary-Interrenal Axis In Atlantic Sturgeon (Acipenser Oxyrinchus) Following An Acute Stressor, Liam Doherty

Undergraduate Theses, Capstones, and Recitals

This study investigated the response to acute stress in Atlantic sturgeon (Acipenser oxyrinchus) and HPI axis regulation of glucocorticoid production during stress by examining the expression of key genes― corticotropin-releasing hormone (crh), corticotropin-releasing hormone receptor (crhr), proopiomelanocortin (pomca/pomcb), melanocortin 2 receptor (mc2r), and steroidogenic acute regulatory protein (star)―that are associated with hypothalamus/pituitary/interrenal (HPI) axis of bony fishes. Additionally, tyrosine hydrogenase (th1 and th2) and phosphoenolpyruvate carboxykinase (pepck), found in catecholamine-producing cells in the head kidney of the sturgeon, were investigated …

Morphological Remodeling Of The Endoplasmic Reticulum During Mitosis And Its Influence On The Integrity Of The Spindle Apparatus, Katie R. Rollins

Electronic Theses and Dissertations

The Endoplasmic Reticulum (ER) is the largest organelle in the cell by surface area and forms contacts with other organelles throughout the cell. In recent work, the ER has been implicated in numerous processes within the cell beyond its canonical roles of protein synthesis and calcium storage. The ER also undergoes a remarkable transition in morphology during cell division, with mitotic divisions requiring a massive remodeling of various membranous organelles such as the nuclear envelope and Golgi. However, whether changes in ER behaviors modulate mitotic events is less clear. The rapid cleavage divisions in the early Drosophila embryo are a …

The Effects Of Wildfire Burn Severity On Bee And Wasp Communities Two Decades Post-Fire, Alaina K. Smith

Electronic Theses and Dissertations

While fire is a natural disturbance in many global ecosystems, anthropogenic changes are affecting fire frequency, severity, and seasonality. Disturbances like wildfire affect bee and wasp communities, but recent meta-analyses are conflicted about whether fire harms or benefits insect pollinators. We investigated the lasting effects of wildfire burn severity on wild bee communities and floral resource availability across different burn severities in two-mixed severity fires that burned >20 years ago. We found that high severity fire has positive effects on bee diversity that are associated with severity-mediated changes to the floral community. We also studied the effects of wildfire burn …

Variance-Components Tests For Genetic Association With Multiple Interval-Censored Outcomes, Jaihee Choi, Zhichao Xu, Ryan Sun

Faculty, Staff and Student Publications

Massive genetic compendiums such as the UK Biobank have become an invaluable resource for identifying genetic variants that are associated with complex diseases. Due to the difficulties of massive data collection, a common practice of these compendiums is to collect interval-censored data. One challenge in analyzing such data is the lack of methodology available for genetic association studies with interval-censored data. Genetic effects are difficult to detect because of their rare and weak nature, and often the time-to-event outcomes are transformed to binary phenotypes for access to more powerful signal detection approaches. However transforming the data to binary outcomes can …

An Investigation Of Cyanobacteria, Cyanotoxins And Environmental Variables In Selected Drinking Water Treatment Plants In New Jersey, Tsung Ta David Hsu, Yaritza Acosta Caraballo, Meiyin Wu

Department of Biology Faculty Scholarship and Creative Works

Harmful Algal Blooms (HAB) have the potential to impact human health primarily through their possible cyanotoxins production. While conventional water treatments can result in the removal of unlysed cyanobacterial cells and low levels of cyanotoxins, during severe HAB events, cyanotoxins can break through and can be present in the treated water due to a lack of adequate toxin treatment. The objectives of this study were to assess the HAB conditions in drinking water sources in New Jersey and investigate relationships between environmental variables and cyanobacterial communities in these drinking water sources. Source water samples were collected monthly from May to …

In-Silico Analysis Of Tmem2 As A Pancreatic Adenocarcinoma And Cancer-Associated Fibroblast Biomarker, And Functional Characterization Of Nsc777201, For Targeted Drug Development, Prateeti Srivastava, Vijesh Kumar Yadav, Tzu-Hao Chang, Emily Chia-Yu Su, Bashir Lawal, Alexander Th Wu, Hsu-Shan Huang

Faculty, Staff and Student Publications

Pancreatic adenocarcinoma (PAAD), known as one of the deadliest cancers, is characterized by a complex tumor microenvironment, primarily comprised of cancer-associated fibroblasts (CAFs) in the extracellular matrix. These CAFs significantly alter the matrix by interacting with hyaluronic acid (HA) and the enzyme hyaluronidase, which degrades HA - an essential process for cancer progression and spread. Despite the critical role of this interaction, the specific functions of CAFs and hyaluronidase in PAAD development are not fully understood. Our study investigates this interaction and assesses NSC777201, a new anti-cancer compound targeting hyaluronidase. This research utilized computational methods to analyze gene expression data …

Statistical Modeling Of Knee Morphology And Material Properties Considering Diverse Populations, Gabrielle Jeannine Kindy

Electronic Theses and Dissertations

Total Knee Arthroplasty (TKA) is a widely performed surgical procedure aimed at alleviating pain and restoring function in patients with severe knee osteoarthritis. Despite its general success, disparities in postoperative outcomes have been observed across different racial and ethnic groups, with minority populations often experiencing less favorable results. One potential avenue for improving the generalizability of orthopaedic implants is using Statistical Shape and Intensity Models (SSIMs), which can be used to incorporate patient variability directly into the orthopaedic medical device development workflow through population-based finite element analysis.

This work aimed to construct an SSIM from a diverse subject set, incorporating …

A Cost-Effective Enzyme Kinetics And Inhibition Model For Biochemistry Education And Research, Lauren Vandee, Alyssa Teague, Taylor East, Kim Rhona Jacinto, Macie Carter, Jacey Totty, Paul D. Adams, Djamali Muhoza

Chemistry & Biochemistry Faculty Publications and Presentations

Enzyme kinetics and inhibition studies are crucial in biochemistry education and research. Conventional methods often require expensive equipment and reagents, potentially limiting their accessibility in limited resource settings. Our approach sought to develop a cost-effective experimental design for studying enzyme kinetics and inhibition. Lactase was chosen as a protein model and its activity was investigated by measuring glucose production from lactose hydrolysis. In the study, commercially available lactase pills were used as an enzyme source, while milk was used as a substrate. Instead of scientific equipment, glucometers were used to measure lactase activity. Enzyme kinetics were evaluated using Michaelis–Menten and …

Reduced Sensitivity To Future Consequences Underlies Gambling Decision In Cerebellar Ataxia, Ruo-Yah Lai, Eli Levy, Christian J Amlang, Ihika Rampalli, Rory Mahabir, Ming-Kai Pan, Chi-Ying R Lin, Sheng-Han Kuo

Faculty, Staff and Students Publications

Introduction: Previous research has identified that people with cerebellar ataxia (CA) showed impaired reward-related decision-making in the Iowa Gambling Task (IGT). To investigate the mechanisms underlying this impairment, we examined CA participants' combination of performance in the IGT, which predominantly tests reward seeking, and the modified IGT (mIGT), which mainly assesses punishment avoidance.

Methods: Fifty participants with CA and one hundred controls completed the IGT and mIGT. Task performance in each of the five twenty-trial blocks was compared between groups and the learning rates were assessed with simple linear regressions. Each participant's IGT score and mIGT score were compared.

Results: …

Developmental Milestones And Daily Living Skills In Individuals With Angelman Syndrome, Anjali Sadhwani, Sonya Powers, Anne Wheeler, Hillary Miller, Sarah Nelson Potter, Sarika U Peters, Carlos A Bacino, Steven A Skinner, Logan K Wink, Craig A Erickson, Lynne M Bird, Wen-Hann Tan

Faculty, Staff and Students Publications

BACKGROUND: Angelman syndrome (AS) is a neurodevelopmental disorder associated with severe global developmental delay. However, the ages at which different developmental skills are achieved in these individuals remain unclear. We seek to determine the probability and the age of acquisition of specific developmental milestones and daily living skills in individuals with AS across the different molecular subtypes, viz. class I deletion, class II deletion, uniparental disomy, imprinting defect, and UBE3A variants.

METHODS: Caregivers participating in a longitudinal multicenter Angelman Syndrome Natural History Study completed a questionnaire regarding the age at which their children achieved specific developmental milestones and daily living …

Deepcg: A Cell Graph Model For Predicting Prognosis In Lung Adenocarcinoma, Baoyi Zhang, Chenyang Li, Jia Wu, Jianjun Zhang, Chao Cheng

Faculty, Staff and Student Publications

Lung cancer is the first leading cause of cancer-related death in the United States, with lung adenocarcinoma as the major subtype accounting for 40% of all cases. To improve patient survival, image-based prognostic models were developed due to the ready availability of pathological images at diagnosis. However, the application of these models is hampered by two main challenges: the lack of publicly available image datasets with high-quality survival information and the poor interpretability of conventional convolutional neural network models. Here, we integrated matched transcriptomic and H&E staining data from TCGA (The Cancer Genome Atlas) to develop an image-based prognostic model, …