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Poland Syndrome And The Sensorimotor Cortex: An Untapped Possibility For Research, Ace Laikind Jun 2024

Poland Syndrome And The Sensorimotor Cortex: An Untapped Possibility For Research, Ace Laikind

Scholarly Horizons: University of Minnesota, Morris Undergraduate Journal

Poland syndrome is a rare disorder that unilaterally affects the chest, arms, and hands. Despite being a limb disorder, there has not been research done on how Poland syndrome interacts with the sensorimotor cortex. Other limb disorders have documented connections to the sensorimotor cortex, and can be used to infer how Poland syndrome affects the sensorimotor cortex. Limb disorders with extensive research on the sensorimotor cortex are phantom limb syndrome, focal hand dystonia, and congenital one-handedness. Additionally, to accommodate for the confound created by the differences between congenital and acquired conditions, blindness and its effects on plasticity can be examined. …

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Predictive Processing And Chronic Pain, Lydia Hurst Jun 2024

Predictive Processing And Chronic Pain, Lydia Hurst

Scholarly Horizons: University of Minnesota, Morris Undergraduate Journal

Chronic pain is a common condition in which sufferers experience pain for over 3 months. The causes of chronic pain are often difficult to discern, as many cases are not associated with physical damage. A predictive processing (PP) perspective proposes that chronic pain results from the brain’s erroneous predictions derived from strong emotional and/or fearful reactions to pain. Individuals with anxiety disorders are more likely to react with fear to general stimuli, and therefore may be more likely to develop chronic pain under this model. The current healthcare model for this condition, which focuses on treating symptoms with pain-killers, displays …

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History, Impacts, And Control Of Purple Loosestrife (Lythrum Salicaria) In Minnesota, Jude Humphrey Jun 2024

History, Impacts, And Control Of Purple Loosestrife (Lythrum Salicaria) In Minnesota, Jude Humphrey

Scholarly Horizons: University of Minnesota, Morris Undergraduate Journal

Purple loosestrife (Lythrum salicaria) is an infamous invasive plant species in wetland habitats. It was introduced to North America through multiple pathways. While herbicides and other attempts to eradicate purple loosestrife have proved mostly ineffective for various reasons, the introduction of the plant’s natural herbivores has shown promise. This paper provides an overview of research done on purple loosestrife’s introduction, biology, impacts, and control methods with an emphasis on its history in Minnesota. Understanding the history and past efforts made to control this plant can be an important reference point for future work.

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The Potential Impact Of Endangered Species Legislation On Federal Grazing Lands And The Livestock Industry, G M. Luciuk, B Bristol, T W. Weins, D M. Boyle Jun 2024

The Potential Impact Of Endangered Species Legislation On Federal Grazing Lands And The Livestock Industry, G M. Luciuk, B Bristol, T W. Weins, D M. Boyle

IGC Proceedings (1977-2023)

Crown based grazing is an integral part of the management structure of cattle operations, and is very important to the economic fabric of rural communities. Federal crown lands, such as the PFRA operated community pastures are an integral part of the resource conservation efforts in western Canada. These lands represent a significant reservoir of the remaining natural lands which are important for wildlife habitat. Sustainable management of such contiguous blocks of land is essential for the maintenance of biodiversity. Proposed endangered species legislation would require the development of recovery plans on federal lands for endangered, threatened and extirpated species. Rural …

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Concepts For Mining Landscape Development In Eastern Germany With Grazing Animals And Agroforestry, S Eichler, F Herzog Jun 2024

Concepts For Mining Landscape Development In Eastern Germany With Grazing Animals And Agroforestry, S Eichler, F Herzog

IGC Proceedings (1977-2023)

Leipzig South (Saxony) has been heavily transformed by open cast lignite mining. Alternative forms of land use are sought which contribute to an increase of biodiversity and an improvement of soil quality. This could be achieved by the selective introduction of grazing animals and perennials. Specific scenarios for open pits, dumping areas, open pits’ slopes and land reclaimed for agriculture are proposed. Socio-economic drawbacks are outlined.

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The Use Of Grasslands To Improve Water Quality In The New York City Watershed, D J. Flaherty, J Drelich Jr Jun 2024

The Use Of Grasslands To Improve Water Quality In The New York City Watershed, D J. Flaherty, J Drelich Jr

IGC Proceedings (1977-2023)

The purpose of this paper is to demonstrate how grasslands are used in the New York City (NYC) Watershed to improve water quality. A Watershed Agricultural Program was established to voluntarily implement Pollution Prevention Best Management Practices on watershed farms. Grasslands have been used in Whole Farm Plans to reduce nutrients, sediments and other toxic materials reaching New York City’s water supply. Rotational grazing has been used to limit access to streams and stream banks and improve nutrient distribution on pastures. Improved grassland management also helps correct the nutrient balance on the farm and facilitates better nutrient management. Brush removal …

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Objective Indicators For Monitoring Drought In Grasslands, D H. White, S M. Howden Jun 2024

Objective Indicators For Monitoring Drought In Grasslands, D H. White, S M. Howden

IGC Proceedings (1977-2023)

Australia’s National Drought Policy was ratified by the Commonwealth (Federal), State and Territory governments in 1992. However, a sequence of El Niño-based events that started in Queensland in 1991 culminated in much of Australia experiencing abnormally low rainfall throughout 1994 and into 1995. Many farmers experienced substantial loss of income. The Commonwealth government therefore devised measures to determine which areas had been exposed to exceptional drought so that financial assistance could be directed as effectively as possible. In this paper we discuss progress in developing regionally-sensitive indicators and methodologies to aid in future assessments of drought exceptional circumstances.

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Are We Ignoring Science In Our Quest For Simplicity In Range Management?, W A. Laycock Jun 2024

Are We Ignoring Science In Our Quest For Simplicity In Range Management?, W A. Laycock

IGC Proceedings (1977-2023)

Accurate determination of range condition and trend is essential for proper range management. In the United States, the range condition model currently used is not based on up-to-date ecological knowledge. It assumes a single stable state (climax) and linear pathways. Multiple stable state models more accurately depict community dynamics but have not been widely accepted. U.S. Federal land management agencies are using surrogates, such as qualitative “instant trend” measures and substitution of utilization for measured condition and trend to guide management. Most of these short cuts are not based on science. Attacks on livestock grazing by environmentalists are based on …

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Socio-Economic And Climate Change In Mongolia - Effects On Grassland Ecosystems, C Opp Jun 2024

Socio-Economic And Climate Change In Mongolia - Effects On Grassland Ecosystems, C Opp

IGC Proceedings (1977-2023)

In Mongolia, in combination with strong changes of the whole society during the past 76 years, from the feudal system to socialism and from the socialist system of planned development to the market economy, there are a lot of changes in the use of natural resources all over the country. In consequence of this a lot of effects on grassland ecosystems, caused by socio-economic and climate driving factors, were observed and studied in different scales: zonal, regional, local.

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Integrating Biophysical And Economic Models For Assessing Impacts Of Change On Grazingland Ecosystems, J De Souza Neto, J R. Conner, J W. Stuth, W T. Hamilton, J W. Richardson Jun 2024

Integrating Biophysical And Economic Models For Assessing Impacts Of Change On Grazingland Ecosystems, J De Souza Neto, J R. Conner, J W. Stuth, W T. Hamilton, J W. Richardson

IGC Proceedings (1977-2023)

PHYGROW, a hydrologic-based forage simulation model, was parameterized to represent a typical South Texas ranch engaged in the production of cattle and meat goats with an indigenous population of white-tailed deer. Forage production and associated stocking rates for two cattle: goat ratios were simulated for 20 years. Two, ten-year weather scenarios, one representing normal conditions (30% drought years) and one representing dryer weather conditions (50% drought years) were analyzed. Management decision rules were developed for the region to produce estimates of annual animal production and operating cost for the enterprises in each of the four scenarios. These performance and cost …

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Linear And Community-Based Processes Of Ethical Decision Making For Grassland Workers, Gary W. Fick Jun 2024

Linear And Community-Based Processes Of Ethical Decision Making For Grassland Workers, Gary W. Fick

IGC Proceedings (1977-2023)

Grasslands are basic elements in sustainable development, but few grassland workers are familiar with concepts of ethical decision making useful in integrating ecological, economic, and sociological components of sustainability. Most published procedures for ethical decision making are based on linear models for individualized social systems with modern technologies. In the context of sustainable agriculture, nonlinear community-based procedures may be more appropriate. In this paper, a nonlinear model from the Haudenosaunee (Iroquois) Indians is compared to more conventional linear procedures. After identification of a problem, linear models often leave the solution of the ethical dilemma (ranking ethical goals when they conflict) …

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Policy Options For Decreasing N And P2o5 Losses From Grassland Based Dairy Farms, P.B M. Berentsen, G.W J. Giesen Jun 2024

Policy Options For Decreasing N And P2o5 Losses From Grassland Based Dairy Farms, P.B M. Berentsen, G.W J. Giesen

IGC Proceedings (1977-2023)

Policy instruments for reducing nutrient losses include extension and education, research, financial incentives such as subsidies and levies, and regulations. The potential of these instruments for reducing nitrogen (N), phosphate (P2O5), and ammonia (NH3) losses is examined for Dutch specialized dairy farms on sandy soils. A linear programming model is used to estimate policy impacts. Results indicate that efficiency improvements through extension, education, and research alone have the potential to decrease total N losses to government target levels in 2005 and to erase 92% of the gap between base and target P2O5 losses, but only 24% of the corresponding NH3 …

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Production V Conservation: A Policy Dilemma In The Tree Clearing Debate In Queensland, Australia, J C. Scanlan, E J. Turner Jun 2024

Production V Conservation: A Policy Dilemma In The Tree Clearing Debate In Queensland, Australia, J C. Scanlan, E J. Turner

IGC Proceedings (1977-2023)

A process for developing policy for tree clearing that meets the competing goals of conservation and production has been followed. There were two levels at which policy was developed. An overall Statewide policy outlined general targets to meet commitments of the Queensland Government. Local guidelines were developed by a large number of groups containing representatives of government and interested conservation movement and industry representatives. The policy and the local guidelines are an important part of the process used to assess applications for permits to clear woody vegetation.

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Forage Production And Performance Of Beef Yearlings Grazing Diploid And Tetraploid Crested Wheatgrass, J D. Bruynooghe, R.D H. Cohen, N W. Holt, P G. Jefferson Jun 2024

Forage Production And Performance Of Beef Yearlings Grazing Diploid And Tetraploid Crested Wheatgrass, J D. Bruynooghe, R.D H. Cohen, N W. Holt, P G. Jefferson

IGC Proceedings (1977-2023)

A series of experiments were conducted during 1994 and 1995 at Swift Current, Saskatchewan, Canada to evaluate forage production and animal performance on tetraploid Kirk (Agropyron cristatum (L.) Gaertn.) and diploid Fairway (Agropyron cristatum (L.) Gaertn.) crested wheatgrass pastures under grazing conditions imposed by beef (Bos taurus) yearling steers at four stock density levels (3, 4, 6 and 8 steers ha-1). Total ungrazed forage production for Kirk was greater (<0.05) than Fairway (6302 kg ha-1 vs. 5235 kg ha-1) in 1994 but less (P<0.05) than Fairway in 1995 (3709 kg ha-1 vs. 4633 kg ha-1). Animal performance (average daily gain, animal grazing days and total animal production) did not differ (P>0.05) for steers grazing either Kirk or Fairway pastures. Plant vigour and available energy reserves following one season of grazing were evaluated through etiolated growth with …

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Vertical Distribution In Grass Swards: Interactions Between Dry Matter And Nutritional Quality, D R. Buckmaster, R H. Mohtar, S L. Fales Jun 2024

Vertical Distribution In Grass Swards: Interactions Between Dry Matter And Nutritional Quality, D R. Buckmaster, R H. Mohtar, S L. Fales

IGC Proceedings (1977-2023)

A field experiment was conducted to study the distribution of mass and quality over plant height throughout the growing season in a pure stand of orchardgrass (Dactylis glomerata L.). When plant density (expressed as kg DM/ha per cm height) is plotted against a height of strata, all treatments show a similar linear shape distribution. ADF and NDF concentrations declined with sward height. Fall treatments had lower ADF and NDF concentrations than summer treatments. Conversely, CP concentrations showed an increase with plant height. Fall treatments showed higher CP than spring and summer treatments. Defoliation management did not affect orchardgrass quality. …

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Application Of The Phygrow Forage Production- Runoff Model For Regional Stocking Analysis, J W. Stuth, J R. Conner, W T. Hamilton, D M. Schmitt Jun 2024

Application Of The Phygrow Forage Production- Runoff Model For Regional Stocking Analysis, J W. Stuth, J R. Conner, W T. Hamilton, D M. Schmitt

IGC Proceedings (1977-2023)

A hydrologic-based forage production model, PHYGROW, was used to simulate forage production and carrying capacity of a subtropical shrubland complex of over 34 species grazed by various ratios of cattle and goats with a population of indigenous white-tailed deer over a 20-yr simulated weather profile. The diet selection algorithm allowed the three animal populations to selectively graze preferred foods based on preferences of plant species, plant parts, and live:dead status by phenological stage. A level of maximum utilization of key species was specified. An incremental analysis of cattle:goat demand ratio was analyzed to determine how different combinations of livestock were …

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Using Nested Paddocks To Study Multiple-Paddock Grazing Systems, B E. Anderson, W W. Stroup, W H. Schacht Jun 2024

Using Nested Paddocks To Study Multiple-Paddock Grazing Systems, B E. Anderson, W W. Stroup, W H. Schacht

IGC Proceedings (1977-2023)

There is insufficient information to guide development of multiple paddock grazing systems. Measuring vegetation responses to grazing period/recovery period intervals is prohibitively expensive when using most grazing research designs. Nested paddock designs reduce land area, number of herds, and number of paddocks needed for comparisons. Nested paddocks permit comparisons of animal performance among whole pasture treatments but comparisons are limited for animal performance differences among grazing/recovery period lengths. Nonetheless, nested paddock designs efficiently document vegetation responses to grazing intervals, which may permit predictions of animal performance.

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Relationship Between Broadleaf Dock (Rumex Obtusifolius L.) And Seasonal Yield Of Orchardgrass Grazed Pasture, Y Iijima, Y Kurokawa, T Monya, Y Suzuki Jun 2024

Relationship Between Broadleaf Dock (Rumex Obtusifolius L.) And Seasonal Yield Of Orchardgrass Grazed Pasture, Y Iijima, Y Kurokawa, T Monya, Y Suzuki

IGC Proceedings (1977-2023)

In order to grasp the ecology of R. obtusifolius and the effects of it on seasonal yield of grass in grazing pasture, we investigated seasonal sward characteristics and dry matter yield in grazing pasture. Dry matter yield and coverage of R. obtusifolius predominated those of grass after mid-June and mid-August, respectively. Throughout the year the coverage of R. obtusifolius negatively correlated to the grass yield. After August, the grass yield was negatively related to the yield and the population density of R. obtusifolius. From the facts described above, R. obtusifolius seems to reduce grass yield throughout the year, especially …

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The Influence Of Light On The Succession Of Calcareous Grassland Using A Gis As An Instrument For Analysis, G Spatz, Th Fricke Jun 2024

The Influence Of Light On The Succession Of Calcareous Grassland Using A Gis As An Instrument For Analysis, G Spatz, Th Fricke

IGC Proceedings (1977-2023)

The change of light transmission along a gradient from shrub center to open grassland and its correlation to vegetation composition has been studied in two shrub surroundings on abandoned calcareous grassland. Light measurements were made at soil surface locations in high density and later interpolated to area maps. Low-growing plants were mapped in plots within the shrub area and their shapes subsequently digitized. Using SPANS GIS an overlay of maps representing light transmission, distance to shrub center and apearance of low-growing plants was made by calculating averages in a specified grid to create data sets for a statistical evaluation. The …

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The Grazing Manager: A New Application Of The Carrying Capacity Concept, M M. Kothmann, R T. Hinnant Jun 2024

The Grazing Manager: A New Application Of The Carrying Capacity Concept, M M. Kothmann, R T. Hinnant

IGC Proceedings (1977-2023)

Common approaches to evaluating carrying capacity are stocking rate trials for research and trial and error adjustments for ranchers. These approaches are inadequate as operational decision guides for grazing management. The Grazing Manager (TGM) is a generalized management level dynamic model that provides a new approach to stocking rate analysis. Grazing pressure is integrated over time with a function called pasture demand ratio (PDR) which is based on cumulative forage demand relative to cumulative forage production within a forage year. PDR is a dynamic variable that standardizes the forage balance relationship and makes the analysis of stocking rate data more …

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Accounting For Selective Grazing In The Stocking Rate Decision, M F. Quirk, J W. Stuth Jun 2024

Accounting For Selective Grazing In The Stocking Rate Decision, M F. Quirk, J W. Stuth

IGC Proceedings (1977-2023)

We describe the development and use of a simple, generic method for predicting botanical composition of herbivore diets, thereby allowing resource managers to consider selective foraging when setting stocking rates. For a particular season and herbivore, we found that forage species fall into one of 3 selection categories: preferred (consistently selected for), undesirable (consistently selected against), and variable (inconsistent selection pattern). Our studies showed that, for most situations, dietary composition is adequately predicted from regression relationships with the field proportions of preferred and undesirable species. We demonstrate how this method can help address issues such as the conservation of preferred …

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Gender And Participation In Popular Music Ensembles: Perspectives Of Modern Band Teachers, Bryan Powell Jun 2024

Gender And Participation In Popular Music Ensembles: Perspectives Of Modern Band Teachers, Bryan Powell

Visions of Research in Music Education

This article explores gender dynamics in popular music education, focusing on the perspectives of modern band teachers across the United States. Drawing from existing literature and a survey of 390 modern band educators, the study examines the extent to which modern band teachers perceive their own gender identities influence student participation and enrollment in elective modern band classes. While the majority of respondents believed their gender does not significantly impact enrollment, female teachers were more likely to indicate that they felt that their gender had an impact on student enrollment compared to their male counterparts. Additionally, the study uncovers challenges …

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Relative Age Effect At Men’S Volleyball World Championships Over Time, Marcin Śliwa, Mariusz Buszta, Jerzy Sadowski Jun 2024

Relative Age Effect At Men’S Volleyball World Championships Over Time, Marcin Śliwa, Mariusz Buszta, Jerzy Sadowski

Baltic Journal of Health and Physical Activity

Introduction: Relative age effect (RAE) in sport is extensively described in the literature. However, there is scarcity of data on how to avoid problems in the talent identification process and, consequently, how to avoid dropping out or losing a potential volleyball talent. The aim of the study was to carry out a retrospective analysis of RAE at Men’s U-19 and U-21 World Championships as well as Men’s World Championships over the last 12 years and to investigate possible differences in quarterly age distribution depending on anthropometric features, geographical regions the teams under study came from as well as their performance …

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Review Of Mpges-1 Inhibitors Based On The Benzoxazole And Its Isostere Scaffold For The Treatment Of Inflammatory Diseases, Abdullah M. Alwagdani Jun 2024

Review Of Mpges-1 Inhibitors Based On The Benzoxazole And Its Isostere Scaffold For The Treatment Of Inflammatory Diseases, Abdullah M. Alwagdani

Longitudinal Scholar's Project

The vital role of the prostanoid pathway in inflammation, pain, cancer, Alzheimer’s and many other diseases has attracted the drug discovery community to discover targets for therapeutic development. Although existing non-steroidal anti-inflammatory drugs (NSAIDs) inhibiting cyclooxygenases (COX) are widely used, the side effects of these NSAIDs limit the ling time medication. Microsomal prostaglandin E synthase-1 (mPGES-1) is an attractive target that is overexpressed during inflammations, and it could be a safe alternative to NSAIDs for treating inflammatory diseases.Since the discovery of mPGES-1 in 1997, many inhibitors have been developed since 2001. Only a few compounds were able to make it …

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Discovering Potential In Non-Cancer Medications: A Promising Breakthrough For Multiple Myeloma Patients., Omar S Al-Odat, Emily Nelson, Tulin Budak-Alpdogan, Subash C. Jonnalagadda, Dhimant Desai, Manoj K Pandey Jun 2024

Discovering Potential In Non-Cancer Medications: A Promising Breakthrough For Multiple Myeloma Patients., Omar S Al-Odat, Emily Nelson, Tulin Budak-Alpdogan, Subash C. Jonnalagadda, Dhimant Desai, Manoj K Pandey

College of Science & Mathematics Departmental Research

Multiple myeloma (MM) is a common type of cancer that unfortunately leads to a significant number of deaths each year. The majority of the reported MM cases are detected in the advanced stages, posing significant challenges for treatment. Additionally, all MM patients eventually develop resistance or experience relapse; therefore, advances in treatment are needed. However, developing new anti-cancer drugs, especially for MM, requires significant financial investment and a lengthy development process. The study of drug repurposing involves exploring the potential of existing drugs for new therapeutic uses. This can significantly reduce both time and costs, which are typically a major …

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A Structural Role For Tryptophan In Proteins, And The Ubiquitous Trp CΔ1—H&Centerdot;&Centerdot;&Centerdot;O=C (Backbone) Hydrogen Bond, Michal Szczygiel, Urszula Derewenda, Steve Scheiner, Wladek Minor, Zygmunt S. Derewenda Jun 2024

A Structural Role For Tryptophan In Proteins, And The Ubiquitous Trp CΔ1—H&Centerdot;&Centerdot;&Centerdot;O=C (Backbone) Hydrogen Bond, Michal Szczygiel, Urszula Derewenda, Steve Scheiner, Wladek Minor, Zygmunt S. Derewenda

Chemistry and Biochemistry Faculty Publications

Tryptophan is the most prominent amino acid found in proteins, with multiple functional roles. Its side chain is made up of the hydrophobic indole moiety, with two groups that act as donors in hydrogen bonds: the Nε—H group, which is a potent donor in canonical hydrogen bonds, and a polarized Cδ1—H group, which is capable of forming weaker, noncanonical bonds. Due to adjacent electron-withdrawing moieties, C—H···O hydrogen bonds are ubiquitous in macromolecules, albeit contingent on the polarization of the donor C—H group. Consequently, Cα groups (adjacent to the carbonyl and amino groups of flanking peptide …

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Assessing The Effects Of Repetitive Mild Traumatic Brain Injury On Risk/Reward Decision Making And Catecholamine Associated Proteins, Christopher Knapp Jun 2024

Assessing The Effects Of Repetitive Mild Traumatic Brain Injury On Risk/Reward Decision Making And Catecholamine Associated Proteins, Christopher Knapp

Theses and Dissertations

Mild traumatic brain injury (mTBI) disrupts cognitive processes that influence risk taking behavior; however, the effects of repetitive mild injury (rmTBI) or whether these outcomes are sex specific are unknown. Risk/reward decision making is mediated by the prefrontal cortex (PFC), which is densely innervated by catecholaminergic fibers. Aberrant PFC catecholamine activity has been documented following TBI and may underlie TBI-induced risky behavior. Here, we exposed rats to sham (no injury), single, or three closed-head controlled cortical impact (CH-CCI) injuries to characterize the effects of rmTBI on 1) risk/reward decision making behavior using a probabilistic discounting task (PDT) and 2) levels …

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Neural Circuits Expressing The Serotonin 2c Receptor Regulate Memory In Mice And Humans, Hesong Liu, Yang He, Hailan Liu, Bas Brouwers, Na Yin, Katherine Lawler, Julia M. Keogh, Elana Henning, Dong Kee Lee, Meng Yu, Longlong Tu, Nan Zhang, Kristine M. Conde, Junying Han, Zili Yan, Nikolas A. Scarcelli, Lan Liao, Jianming Xu, Qingchun Tong, Hui Zheng, Zheng Sun, Yongjie Yang, Chunmei Wang, Yanlin He, I. Sadaf Farooqi, Yong Xu Jun 2024

Neural Circuits Expressing The Serotonin 2c Receptor Regulate Memory In Mice And Humans, Hesong Liu, Yang He, Hailan Liu, Bas Brouwers, Na Yin, Katherine Lawler, Julia M. Keogh, Elana Henning, Dong Kee Lee, Meng Yu, Longlong Tu, Nan Zhang, Kristine M. Conde, Junying Han, Zili Yan, Nikolas A. Scarcelli, Lan Liao, Jianming Xu, Qingchun Tong, Hui Zheng, Zheng Sun, Yongjie Yang, Chunmei Wang, Yanlin He, I. Sadaf Farooqi, Yong Xu

Division of Basic Science Faculty Publications

Declined memory is a hallmark of Alzheimer’s disease (AD). Experiments in rodents and human postmortem studies suggest that serotonin (5-hydroxytryptamine, 5-HT) plays a role in memory, but the underlying mechanisms are unknown. Here, we investigate the role of 5-HT 2C receptor (5-HT2CR) in regulating memory. Transgenic mice expressing a humanized HTR2C mutation exhibit impaired plasticity of hippocampal ventral CA1 (vCA1) neurons and reduced memory. Further, 5-HT neurons project to and synapse onto vCA1 neurons. Disruption of 5-HT synthesis in vCA1-projecting neurons or deletion of 5-HT2CRs in the vCA1 impairs neural plasticity and memory. We show that a selective 5-HT2CR agonist, …

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Harnessing Redox Polymer Dynamics For Enhanced Glucose-Oxygen Coupling In Dual Biosensing And Therapeutic Applications, Wassim El Housseini, Egor Baiarashov, Rokas Gerulskis, Adam Milam, Shelley D. Minteer Jun 2024

Harnessing Redox Polymer Dynamics For Enhanced Glucose-Oxygen Coupling In Dual Biosensing And Therapeutic Applications, Wassim El Housseini, Egor Baiarashov, Rokas Gerulskis, Adam Milam, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

The burgeoning field of continuous glucose monitoring (CGM) for diabetes management faces significant challenges, particularly in achieving precise and stable biosensor performance under changing environmental conditions such as varying glucose concentrations and O2 levels. To address this, we present a novel biosensor based on the electroless coupling of glucose oxidation catalyzed by flavin-dependent glucose dehydrogenase (FAD-GDH) and O2 reduction catalyzed by bilirubin oxidase (BOD) via a redox polymer, dimethylferrocene-modified linear poly(ethylenimine), FcMe2-LPEI. Initial cyclic voltammetry tests confirm the colocalization of both enzymatic reactions within the potential range of the polymer, indicating an effective electron shuttle mechanism. …

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Manufacturing Of Aligned Electrospun Nanofiber Yarns For Their Enhanced Mechanical And Piezoelectric Properties, Adaugo Mary-Frances Enuka Jun 2024

Manufacturing Of Aligned Electrospun Nanofiber Yarns For Their Enhanced Mechanical And Piezoelectric Properties, Adaugo Mary-Frances Enuka

Theses and Dissertations

Electrospinning is a widely used technique for producing nanofibers with diverse applications. This method uses polymer solutions and strong electric fields to generate nano-sized fibers with unique properties. This study presents a novel manufacturing approach that enables the production of electrospun poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) nanofiber yarns using an automated parallel track system and an adjustable roll-to-roll collector. This research examines the impact of an automated post-drawing system on the polymer chain orientation, crystallinity, tensile strength, morphology, and piezoelectric properties of PVDF-HFP nanofiber yarn. The results reveal that the post-drawing process significantly improves molecular alignment, increases tensile strength, and enhances the …

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