Digital Commons Network^™

Faculty’S Role In Creating A (Remote) Sense Of Community Among Faculty And Facilitating Contexts Of Care For Students, Jesus R. Nunez, Jesus Cisneros, Isela Pena

Higher Learning Research Communications

Objectives: This qualitative study employed a sensemaking approach to understand faculty members’ sensemaking of their roles during the COVID-19 pandemic and the emergency transition to remote teaching and learning.

Methods: An email invitation to participate in the study was sent to faculty who taught in an MBA program during both the 2019–2020 and 2020–2021 academic school years. Data were collected through in-depth, semi-structured interviews with 14 faculty members who self-selected to participate in the study.

Results: Two salient themes emerged from the research: creating a (remote) sense of community among faculty and facilitating contexts of care for students. These …

Learning To Express Reward Prediction Error-Like Dopaminergic Activity Requires Plastic Representations Of Time, Ian Cone, Claudia Clopath, Harel Z Shouval

Faculty, Staff and Student Publications

The dominant theoretical framework to account for reinforcement learning in the brain is temporal difference learning (TD) learning, whereby certain units signal reward prediction errors (RPE). The TD algorithm has been traditionally mapped onto the dopaminergic system, as firing properties of dopamine neurons can resemble RPEs. However, certain predictions of TD learning are inconsistent with experimental results, and previous implementations of the algorithm have made unscalable assumptions regarding stimulus-specific fixed temporal bases. We propose an alternate framework to describe dopamine signaling in the brain, FLEX (Flexibly Learned Errors in Expected Reward). In FLEX, dopamine release is similar, but not identical …

A Hybrid Epithelial/Mesenchymal State In Head And Neck Cancer: A Biomarker For Survival With Differential Prognosis By Self-Reported Race, Angela L Mazul, Thomas F Barrett, Graham Colditz, Anuraag S Parikh, Salma Ramadan, Jose P Zevallos, Jason T Rich, R Alex Harbison, Ryan S Jackson, Patrik Pipkorn, Paul Zolkind, Itay Tirosh, Sidharth V Puram

2020-Current year OA Pubs

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is the 6

METHODS: Given the overlap in gene expression between hybrid E/M malignant cells and cancer-associated fibroblasts, we utilized deconvolution of bulk RNA sequencing data from oral cavity and laryngeal squamous cell carcinoma tumors from The Cancer Genome Atlas. We utilized our previously collected single-cell profiles to generate inferred malignant profiles and then scored these for hybrid E/M. We then conducted a survival analysis on overall and disease-free survival among self-reported Black and White Americans.

FINDINGS: The hybrid E/M state was differentially associated with head and neck cancer survival by self-reported …

Pulmonary Osteoclast-Like Cells In Silica Induced Pulmonary Fibrosis, Yoshihiro Hasegawa, Steven L Teitelbaum, Et Al.

2020-Current year OA Pubs

The pathophysiology of silicosis is poorly understood, limiting development of therapies for those who have been exposed to the respirable particle. We explored mechanisms of silica-induced pulmonary fibrosis in human lung samples collected from patients with occupational exposure to silica and in a longitudinal mouse model of silicosis using multiple modalities including whole-lung single-cell RNA sequencing and histological, biochemical, and physiologic assessments. In addition to pulmonary inflammation and fibrosis, intratracheal silica challenge induced osteoclast-like differentiation of alveolar macrophages and recruited monocytes, driven by induction of the osteoclastogenic cytokine, receptor activator of nuclear factor κΒ ligand (RANKL) in pulmonary lymphocytes, and …

Thermodynamic Coupling Of The Tandem Rrm Domains Of Hnrnp A1 Underlie Its Pleiotropic Rna Binding Functions, Jeffrey D Levengood, Davit Potoyan, Srinivasa Penumutchu, Abhishek Kumar, Qianzi Zhou, Yiqing Wang, Alexandar L Hansen, Sebla Kutluay, Julien Roche, Blanton S Tolbert

2020-Current year OA Pubs

The functional properties of RNA binding proteins (RBPs) require allosteric regulation through interdomain communication. Despite the importance of allostery to biological regulation, only a few studies have been conducted to describe the biophysical nature by which interdomain communication manifests in RBPs. Here, we show for hnRNP A1 that interdomain communication is vital for the unique stability of its amino-terminal domain, which consists of two RNA recognition motifs (RRMs). These RRMs exhibit drastically different stability under pressure. RRM2 unfolds as an individual domain but remains stable when appended to RRM1. Variants that disrupt interdomain communication between the tandem RRMs show a …

Genetic And Multi-Omic Resources For Alzheimer Disease And Related Dementia From The Knight Alzheimer Disease Research Center, Maria Victoria Fernandez, Menghan Liu, Aleksandra Beric, Matt Johnson, Arda Cetin, Maulik Patel, John Budde, Pat Kohlfeld, Kristy Bergmann, Joseph Lowery, Allison Flynn, William Brock, Brenda Sanchez Montejo, Jen Gentsch, Nicholas Sykora, Joanne Norton, Jen Gentsch, Olga Valdez, Priyanka Gorijala, Jessie Sanford, Yichen Sun, Ciyang Wang, Dan Western, Jigyasha Timsina, Tassia Mangetti Goncalves, Anh N Do, Yun Ju Sung, Guoyan Zhao, John C Morris, Krista Moulder, David M Holtzman, Randall J Bateman, Celeste Karch, Jason Hassenstab, Chengjie Xiong, Suzanne E Schindler, Joyce Joy Balls-Berry, Tammie L S Benzinger, Richard J Perrin, Andrea Denny, B Joy Snider, Susan L Stark, Laura Ibanez, Carlos Cruchaga

2020-Current year OA Pubs

The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molecular understanding of Alzheimer Disease. Over more than 40 years, research volunteers have been recruited to participate in cognitive, neuropsychologic, imaging, fluid biomarkers, genomic and multi-omic studies. Tissue and longitudinal data collected to foster, facilitate, and support research on dementia and aging. The Genetics and high throughput -omics core (GHTO) have collected of more than 26,000 biological samples from 6,625 Knight-ADRC participants. Samples available include longitudinal DNA, RNA, non-fasted plasma, cerebrospinal fluid pellets, …

Giardiasis: A Review Study In Iraq, Sarah Kamal Naser

Al-Ameed Journal for Medical Research and Health Sciences

Background: Giardia lamblia is the parasite that causes giardiasis, small intestine infection can result in severe issues and persistent symptoms, especially in children, giardiasis is a common diarrheal disease that can affect anyone everywhere in the world. It may not show any signs at all or it may result in symptoms like intermittent flatulence or persistent malabsorption, Giardia antigen  test,  molecular test for the presence of parasite DNA in feces, and identification of the organism in fresh stool or duodenal contents are all methods of diagnosis.

Aims: Finding the prevalence of giardiasis among cities is the purpose of this review …

A Rehabilitation Of The Body As Home: Reconstructing Young’S Feminist Phenomenology, Amanda Nicole C. Collantes

Budhi: A Journal of Ideas and Culture

This essay investigates Iris Marion Young’s account of female bodily experience and reconstructs her feminist phenomenology with the aim of reinterpreting and enriching the tradition of embodiment using feminist critique. It offers a clearer, more cohesive reconstruction of Young’s phenomenology by referencing three essays where she considers a particular aspect of women’s lived bodily experiences. It considers three recurring themes that appear in and are developed in the three main essays by Young referred to throughout the study. It presents personal, lived experience as political, thus encouraging social cooperation and women’s solidarity through collective meaning-making and a recovery of our …

Immanuel Kant’S Transcendental Idealism: On The Possibility Of Freedom In A Deterministic World, Anamarie R. Avecilla

Budhi: A Journal of Ideas and Culture

Freedom is a central question in Philosophy. It has always been asked: How do determinism and freedom cohere in a human being? How can the fact that humans exist and undertake life projects in a thoroughgoingly deterministic world be reconciled with the claim that human acts remain free and efficacious? This work explores the problem of freedom and determinism using Kant’s answer in the Third Antinomy in the Kritik der reinen Vernunft, and using Transcendental Idealism as epistemological framework for a possible resolution to this problem. If one could assume with Kant that what we know are not things in …

“Sapere Aude!” (“Dare To Know!”): Learn To Teach Feminism, Rainier A. Ibana

Budhi: A Journal of Ideas and Culture

No abstract provided.

Pharmacological Supplements Efficacy In Management Of Chronic Pain Associated With Sickle Cell Disease: A Narrative Review, Ahmad Al-Jalehawi, Samer Imad Mohammed

Maaen Journal for Medical Sciences

Sickle cell disease (SCD) is a hereditary ailment that can cause severe pain and suffering to people who are affected. However, with continued investment in research and treatment options, we can make progress towards improving the lives of those with SCD. Over 40% of patients experience painful vaso-occlusive crises (VOCs), so we must work towards finding solutions and providing support for those living with this condition, These episodes, a hallmark of SCD, significantly contribute to morbidity, mortality, and a diminished quality of life, while also incurring substantial healthcare costs. Chronic pain particularly affects older adolescents and adults with SCD, with …

The Effect Of Resisted Sprint Training On Acceleration: A Systematic Review And Meta-Analysis, Elizabeth K. Aldrich, Katherine Sullivan, Jonathan E. Wingo, Michael R. Esco, James Leeper, Mark T. Richardson, Lee J. Winchester, Michael V. Fedewa

International Journal of Exercise Science

International Journal of Exercise Science 17(6): 986-1002, 2024. Resisted sprint (RS) training, such as sled or parachute towing, is commonly used for sprint training among field sport athletes. While RS training is frequently employed by athletes and coaches, there is little research on its benefits, especially compared to unresisted running (UR) training programs with similar training volumes. This systematic review and meta-analysis compared the effectiveness of RS training on acceleration compared to UR training. Potential sources were limited to peer-reviewed articles published in English prior to June 12, 2022, and gathered from the EBSCOhost, PubMed, and Web of Science online …

The Effect Of Blended Learning On Developing Scientific Concepts In Biology Textbook Among Tenth-Grade Students, Faraj Radwan, Ali Al-Omari

Jordan Journal of Applied Science-Humanities Series

This study aimed to investigate the effect of blended learning on developing scientific concepts in biology textbooks among tenth-grade students. The study sample consisted of 63 tenth-grade students from Jubbeh Secondary Schools in Jerash Governorate. They were divided into two groups: an experimental group of 32 students and a control group of 31 students. To achieve the study's objectives, a quasi-experimental approach was employed, and scientific concepts were tested for data collection. The results showed statistically significant differences in the students' responses to the scientific concepts test, favoring the experimental group. It also indicated a significant impact of blended learning …

The Extent To Which Public School Principals In The Bani Obaid District Education Directorate Practice The Principles Of Reddin's Three-Dimensional Leadership Theory And Its Relationship To Teachers' Job Performance, Nael Al-Omari, Adnan Al-Ibrahim

Jordan Journal of Applied Science-Humanities Series

This study aimed to identify the extent to which public school principals in the Bani Obaid District Education Directorate practice the principles of Reddin's three-dimensional leadership theory and its relationship to teachers' job performance. The study involved 1,310 male and female teachers, with a sample of 300 teachers selected using the convenience sampling method. The results indicated that the practice of leadership principles was at a moderate level, with the domain of duties and tasks ranking first, followed by effectiveness, and lastly human relations. Similarly, the level of job performance among teachers was found to be moderate, with the attitude …

Inter-Kingdom Communication And The Sympoietic Way Of Life, Scott F. Gilbert

Biology Faculty Works

Organisms are now seen as holobionts, consortia of several species that interact metabolically such that they sustain and scaffold each other’s existence and propagation. Sympoiesis, the development of the symbiotic relationships that form holobionts, is critical for our understanding the origins and maintenance of biodiversity. Rather than being the read-out of a single genome, development has been found to be sympoietic, based on multigenomic interactions between zygote-derived cells and symbiotic microbes. These symbiotic and sympoietic interactions are predicated on the ability of cells from different kingdoms of life (e.g., bacteria and animals) to communicate with one another and to have …

The Use Of Preprints In Doctorate Programs: A Citation Analysis Study Of Trends In Chemistry And Physics Dissertations, Amanda Mccormick, Elizabeth Brown, Kathleen Flynn, Clara Tran

Law Librarian Journal Articles

Preprint articles are available on servers, such as arXiv and ChemRxiv, at no-cost to benefit the movement toward open access of research. However, the use of preprint research articles as a reference source in academia is not heavily documented. To examine if researchers are utilizing preprint articles, this paper examines citation trends in the dissertations of chemistry and physics PhD candidates who studied at four University Centers in the State University Of New York system (SUNY). Using citation analysis methodology, references cited in PhD dissertations published between 2018–2021 were analyzed. Key findings showed that PhD candidate authors cited preprint articles …