Digital Commons Network^™

Specific Patterns Of Endogenous Functional Connectivity Are Associated With Harm Avoidance In Obsessive-Compulsive Disorder, Merage Ghane, Lucas Trambaiolli, Michele A Bertocci, Freddyson J Martinez-Rivera, Henry W Chase, Tyler Brady, Alex Skeba, Simona Graur, Lisa Bonar, Satish Iyengar, Gregory J Quirk, Steven A Rasmussen, Suzanne N Haber, Mary L Phillips

Faculty, Staff and Student Publications

Background: Individuals with obsessive-compulsive disorder (OCD) show persistent avoidance behaviors, often in the absence of actual threat. Quality-of-life costs and heterogeneity support the need for novel brain-behavior intervention targets. Informed by mechanistic and anatomical studies of persistent avoidance in rodents and nonhuman primates, our goal was to test whether connections within a hypothesized persistent avoidance-related network predicted OCD-related harm avoidance (HA), a trait measure of persistent avoidance. We hypothesized that 1) HA, not an OCD diagnosis, would be associated with altered endogenous connectivity in at least one connection in the network; 2) HA-specific findings would be robust to comorbid symptoms; …

Variations Of Inflammatory Markers Levels (Esr And Crp) In The Perioperative Period Of Total Knee Arthroplasty, Khalil Ibrahim Sadiq, Mohamedbakir Abbas Abdulzahra, Rafid Mousa Jaffar

Iraqi National Journal of Medicine

Background: The preferred method of treatment for severe osteoarthritis of the knee is total knee arthroplasty (TKA). TKA has been linked to a significant increase in inflammatory markers such as erythrocyte sedimentation rate (ESR)—a test that measures how quickly red blood cells settle to the bottom of a test tube—and C-reactive protein (CRP)—a protein made by the liver that increases when there’s inflammation in the body. Aim: Assessment of the typical time trend and physiological kinetics of CRP and ESR during the early postoperative period over 4 weeks Methods: The study was conducted in the Basrah arthroplasty center, from June …

Comparative Analyses Of Immune Marker Levels In Seronegative And Seropositive Iraqi Rheumatoid Arthritis Patients, Ahmed Aledany, Eman Tariq Ali Altaee, Ali Nazar Mohammed, Falah Hassan Shari Alsukainy

Iraqi National Journal of Medicine

Background: Rheumatoid arthritis (RA) comprises an inflammation-based condition with a clinical phenotype that is mainly reliant on the occurrence of rheumatoid factor and anti-citrullinated protein antibodies. Literature indicates that seronegativity might be accompanied by higher severity of clinical symptoms, while higher disease activity, based on the recent classification criteria should also be associated with seronegativity. Aim: This investigation targets the identification of more efficient immune markers of RA seropositivity as well as examining the possibility that the latter is associated with lower severity. Methods: Serum samples from 128 RA patients, 106 seropositive and 22 seronegative, were analyzed using ELISA to …

Brain-Age Prediction: Systematic Evaluation Of Site Effects, And Sample Age Range And Size, Yuetong Yu, Hao-Qi Cui, Shalaila S Haas, Faye New, Nicole Sanford, Kevin Yu, Denghuang Zhan, Guoyuan Yang, Jia-Hong Gao, Dongtao Wei, Jiang Qiu, Nerisa Banaj, Dorret I Boomsma, Alan Breier, Henry Brodaty, Randy L Buckner, Jan K Buitelaar, Dara M Cannon, Xavier Caseras, Vincent P Clark, Patricia J Conrod, Fabrice Crivello, Eveline A Crone, Udo Dannlowski, Christopher G Davey, Lieuwe De Haan, Greig I De Zubicaray, Annabella Di Giorgio, Lukas Fisch, Simon E Fisher, Barbara Franke, David C Glahn, Dominik Grotegerd, Oliver Gruber, Raquel E Gur, Ruben C Gur, Tim Hahn, Ben J Harrison, Sean Hatton, Ian B Hickie, Hilleke E Hulshoff Pol, Alec J Jamieson, Terry L Jernigan, Jiyang Jiang, Andrew J Kalnin, Sim Kang, Nicole A Kochan, Anna Kraus, Jim Lagopoulos, Luisa Lazaro, Brenna C Mcdonald, Colm Mcdonald, Katie L Mcmahon, Benson Mwangi, Fabrizio Piras, Raul Rodriguez-Cruces, Jessica Royer, Perminder S Sachdev, Theodore D Satterthwaite, Andrew J Saykin, Gunter Schumann, Pierluigi Sevaggi, Jordan W Smoller, Jair C Soares, Gianfranco Spalletta, Christian K Tamnes, Julian N Trollor, Dennis Van't Ent, Daniela Vecchio, Henrik Walter, Yang Wang, Bernd Weber, Wei Wen, Lara M Wierenga, Steven C R Williams, Mon-Ju Wu, Giovana B Zunta-Soares, Boris Bernhardt, Paul Thompson, Sophia Frangou, Ruiyang Ge, Enigma‐Lifespan Working Group

Faculty, Staff and Student Publications

Structural neuroimaging data have been used to compute an estimate of the biological age of the brain (brain‐age) which has been associated with other biologically and behaviorally meaningful measures of brain development and aging. The ongoing research interest in brain‐age has highlighted the need for robust and publicly available brain‐age models pre‐trained on data from large samples of healthy individuals. To address this need we have previously released a developmental brain‐age model. Here we expand this work to develop, empirically validate, and disseminate a pre‐trained brain‐age model to cover most of the human lifespan. To achieve this, we selected the …

Intratumoral Microbiome Of Adenoid Cystic Carcinomas And Comparison With Other Head And Neck Cancers, Tatiana V Karpinets, Yoshitsugu Mitani, Chia-Chi Chang, Xiaogang Wu, Xingzhi Song, Ivonne I Flores, Lauren K Mcdaniel, Yasmine M Hoballah, Fabiana J Veguilla, Renata Ferrarotto, Lauren E Colbert, Nadim J Ajami, Robert R Jenq, Jianhua Zhang, Andrew P Futreal, Adel K El-Naggar

Faculty, Staff and Student Publications

Adenoid cystic carcinoma (ACC) is a rare, usually slow-growing yet aggressive head and neck malignancy. Despite its clinical significance, our understanding of the cellular evolution and microenvironment in ACC remains limited. We investigated the intratumoral microbiomes of 50 ACC tumor tissues and 33 adjacent normal tissues using 16S rRNA gene sequencing. This allowed us to characterize the bacterial communities within the ACC and explore potential associations between the bacterial community structure, patient clinical characteristics, and tumor molecular features obtained through RNA sequencing. The bacterial composition in the ACC was significantly different from that in adjacent normal salivary tissue, and the …

Establishing Updated Safety Standards For Independent (99)(M)Tc-Maa Spect/Ct Treatment Planning In Radioembolization, Taehyung Kim, Ripal Gandhi, Ranjini Tolakanahalli, Raul Herrera, Michael Chuong, Alonso Gutierrez, Diane Alvarez

All Publications

Purpose: Significant improvements within radioembolization imaging and dosimetry permit the development of an accurate and personalized pretreatment plan using technetium 99m-labeled macroaggregated albumin (99mTc-MAA) and single-photon emission computed tomography (SPECT) combined with anatomical CT (SPECT/CT). Despite these potential advantages, the clinical transition to pretreatment protocols with SPECT/CT is hindered by their unknown safety constraints. This study aimed to address this issue by establishing novel dose limits for 99mTc-MAA SPECT/CT to enable quantitative pretreatment planning.

Methods and materials: Stratification criteria to determine images most viable for dosimetry analysis were created from a cohort of 85 patients. SPECT/CT, cone beam CT, and …

A Lifestyle Who Is Christ: An Integrative Model Of Spiritual Formation, Katherine L. Pang

Doctoral Dissertations and Projects

The field of spiritual formation is replete with models, ways, and processes, including many that propose the integration of psychology and Christianity and have further examined the psychology of Paul. Yet, none emphasize the impact of neuroscience, our brain function, neurochemistry, and neurobiology integrated with the tools and techniques of psychological science facilitated by the Holy Spirit and scripture-based truths derived primarily from Pauline theology in the Christ-follower for growth in spiritual maturity. A model formulated from Pauline theology, psychology, and neuroscience, as such, is novel within the field of spiritual formation. Therefore, the claim stems from the need for …

The Relationship Between Resilience, Psychological Capital, Burnout, And Grit In Direct Care Staff, Nicholas Stoia

Doctoral Dissertations and Projects

The present study examined the relationship between resilience, psychological capital (PsyCap), grit, and burnout among direct care workers. The current study assessed other fields within direct care that have not been investigated. When it comes to research methodology, the current research utilized a quantitative approach. Participants were selected and sent the survey through the online platform. The present study had a total of 195 participants between the ages of 18 - 60. Participants were workers in agency settings within the direct care field. These agencies included state agencies, private agencies, non-profits, federal agencies, and home care. Specific types of direct …

The Preeminent Biblical Role Of The Father: A Qualitative Action Research Project, Frank Wilhelm Heilmeier

Doctoral Dissertations and Projects

Fathers have a biblical role to teach their children commandments, statutes, judgments, and God's Law. The father's duty to teach his children should be handed down from generation to generation. The assumption is that fathers do not teach their children as God commanded. When fathers do not teach their children, they risk becoming an absentee father which leads to fatherlessness, ultimately ending in a broken home. To address this issue and offset this risk, a qualitative action research project was conducted. This intervention implemented two small group training sessions for fathers with children ages six and under. The sessions were …

Provider Implementation Of Probiotics As An Adjuvant Treatment Modality For Patients With Anxiety And Or Depression In A Primary Care Setting, Sarah Dedmon

Doctoral Dissertations and Projects

The prevalence of anxiety and depression among Americans is growing rapidly. Patients are seeking out traditional treatments as offered by their primary care providers, but also frequently look toward integrative or complementary methods of managing their symptoms. The use of dietary supplements is at an all-time high, yet the U.S. Food and Drug Administration does not regulate these substances for potency and purity or evaluate them using quality standards as it does pharmaceuticals. Most providers lack education regarding the physiological interaction their patients may experience when using these substances and are naïve to their place in primary care medicine. The …

Teacher Perceptions Of Principal Personality And Intent To Remain: A Causal-Comparative Study, Brittani Leanna Blair

Doctoral Dissertations and Projects

The purpose of this quantitative, causal-comparative study is to explore the relationship between teachers' perceptions of their principals' personality traits, based on the big-five factor structure, and the teachers' intentions to remain in the teaching profession. Research indicates school leadership significantly influences American teachers' commitment to teaching, highlighting the need to understand teachers' perceptions of principal personality traits given the teacher shortage crisis in the United States. Data from a sample of 278 teachers was collected using an online Qualtrics survey that included the M5-50 personality questionnaire items and an item related to teacher intent to remain in the profession. …

Social Skill Development In Teenagers With Autism Who Are Homeschooled In Rural Southwest: A Phenomenological Study Of The Lived Experience Of Caregivers, Sondra J. Bistline

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study was to describe the caregiver's lived experience of social skill development in their teenage or young adult students who have autism. Vygotsky's social constructivism theory frames the structure of social development within the student's family, community, and local culture. The central research question guiding this study was, what were the caregivers' lived experiences of social interactions with their homeschooled teenager or young adult diagnosed with autism? All participants were caregivers of teenage or young adult students diagnosed with autism who received all or part of their schooling through homeschooling, micro-schooling, or habilitation services …

A History Of The Development Of Alternatives To Animals In Research And Testing, John Parascandola

New Directions in the Human-Animal Bond

Growing public interest in animal welfare issues in recent decades has prompted increased attention to the efforts to develop alternative, nonanimal methods for use in biomedical research and product testing. In A History of the Development of Alternatives to Animals in Research and Testing, the first book-length study of the subject, John Parascandola traces the history of the concept of alternatives to the use of animals in research and testing in Britain and the United States from its beginnings until it had become firmly established in the scientific and animal protection communities by the end of the 1980s. This …

Elevational Gradients Shape Bee Network Structure And Community Composition Across Tropical Lowland To Montane Forests In Costa Rica, Jenny Hsu

Online Theses and Dissertations

Mutualistic networks, such as those between plants and pollinators, play a crucial role in ecosystem stability and resilience. Previous theoretical work has posited that mutualistic networks with higher diversity, connectance, nestedness, interaction diversity and more generalist species are more resilient and stable. However, in some ecosystems, specialized interactions and specialists may promote network stability. Drivers of network properties in the neotropics, especially low and mid-elevations, remain relatively unknown, and thus this area should receive special attention. Replicated empirical networks comparing properties along environmental gradients in these regions can help contribute to resolving this debate. A total of 28 networks, replicated …

Deterioration Of Bio-Based Polylactic Acid Plastic Teabags Under Environmental Conditions And Their Associated Effects On Earthworms, Winnie Courtene-Jones, Fannie Burgevin, Lily Munns, Maia B. T. Shillam, Francesca De Falco, Antoine Buchard, Richard Handy, Richard Thompson, Mick Hanley

School of Biological and Marine Sciences

In response to the plastic waste crisis, teabag producers have substituted the petrochemical-plastic content of their products with bio-based, biodegradable polymers such as polylactic acid (PLA). Despite widespread use, the degradation rate of PLA/PLA-blended materials in natural soil and their effects on soil biota are poorly understood. This study examined the percentage mass deterioration of teabags with differing cellulose:PLA compositions following burial (−10 cm depth) in an arable field margin for 7-months, using a suite of analytical techniques, such as size exclusion chromatography, 1H nuclear magnetic resonance, dynamic scanning calorimetry, and scanning electron microscopy. The effect of 28-d exposure to …

Elevating Black Fathers' Experiences In The National Fatherhood Initiative: Strengths And Areas For Improvement Of 24/7 Dad® Curriculum And Case Management Services, Laura A. Voith, Katie N. Russell, Ashley Withrow, Tian Xia, Darrell Coleman

Faculty Scholarship

The Healthy Marriage and Responsible Fatherhood grant program is one of the most robust mechanisms supporting fatherhood programming in the United States, with the gold standard of care including fatherhood curriculum (e.g., 24/7 Dad®) and case management services. Despite the fact that fatherhood in the United States is not a monolith and Black fathers make up over 40% of those served through Responsible Fatherhood (RF) program, little research explicitly centers the lived experiences of low-income Black fathers. The current study used focus groups with fathers (n = 23) and staff (n = 8) enrolled in a RF grantee program. Thematic …

Single-Cell Total-Rna Profiling Unveils Regulatory Hubs Of Transcription Factors, Yichi Niu, Jiayi Luo, Chenghang Zong

Faculty, Staff and Students Publications

Recent development of RNA velocity uses master equations to establish the kinetics of the life cycle of RNAs from unspliced RNA to spliced RNA (i.e., mature RNA) to degradation. To feed this kinetic analysis, simultaneous measurement of unspliced RNA and spliced RNA in single cells is greatly desired. However, the majority of single-cell RNA-seq chemistry primarily captures mature RNA species to measure gene expressions. Here, we develop a one-step total-RNA chemistry-based single-cell RNA-seq method: snapTotal-seq. We benchmark this method with multiple single-cell RNA-seq assays in their performance in kinetic analysis of cell cycle by RNA velocity. Next, with LASSO regression …

Tractography-Based Modeling Explains Treatment Outcomes In Patients Undergoing Deep Brain Stimulation For Obsessive-Compulsive Disorder, Ron Gadot, Ningfei Li, Ben Shofty, Michelle Avendano-Ortega, Sarah Mckay, Kelly R Bijanki, Meghan E Robinson, Garrett Banks, Nicole Provenza, Eric A Storch, Wayne K Goodman, Andreas Horn, Sameer A Sheth

Faculty, Staff and Students Publications

BACKGROUND: Deep brain stimulation (DBS) is an established and expanding therapy for treatment-refractory obsessive-compulsive disorder. Previous work has suggested that a white matter circuit providing hyperdirect input from the dorsal cingulate and ventrolateral prefrontal regions to the subthalamic nucleus could be an effective neuromodulatory target.

METHODS: We tested this concept by attempting to retrospectively explain through predictive modeling the ranks of clinical improvement as measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) in 10 patients with obsessive-compulsive disorder who underwent DBS to the ventral anterior limb of internal capsule with subsequent programming uninformed by the putative target tract.

RESULTS: Rank …

Short-Term Time-Series Observations Of Phytoplankton Light-Absorption And Productivity In Prydz Bay, Coastal Antarctica, Sarat C. Tripathy, Anvita U. Kerkar, P. Sabu, Sunil K. Padhi, Sudarsana R. Pandi, Amit Sarkar, Bhaskar V. Parli, Rahul Mohan

Biology Faculty Publications and Presentations

The optical characteristics of coastal Antarctic waters exhibit complexity due to the dynamic hydrography influenced by meltwater intrusion, which alters nutrient levels, thermohaline structure, and optically active substances (OAS) regimes. Studies on bio-optical variability and its implications on phytoplankton productivity (PP) are scanty in coastal polar regions. On this backdrop, time-series measurements (72 h at 6 h intervals) of bio-optical properties such as phytoplankton biomass (chlorophyll-a), absorption (aph), and total suspended matter (TSM) concurrently with PP were measured to understand their interplay and variability in relation to the ambient physicochemical settings in the under-sampled Prydz Bay, coastal Antarctica. Our findings …

Partial Models For Building Adaptive Model-Based Reinforcement Learning Agents

Defensive Publications Series

In neuroscience, one of the key behavioral tests for determining whether a subject of study exhibits model-based behavior is to study its adaptiveness to local changes in the environment. In reinforcement learning, however, recent studies have shown that modern model-based agents display poor adaptivity to such changes. The main reason for this is that modern agents are typically designed to improve sample efficiency in single task settings and thus do not take into account the challenges that can arise in other settings. In local adaptation settings, one particularly important challenge is in quickly building and maintaining a sufficiently accurate model …

Effective Protein-Protein Interaction Exploration With Ppiretrieval

Defensive Publications Series

Protein-protein interactions (PPIs) are crucial in regulating numerous cellular functions, including signal transduction, transportation, and immune defense. As the accuracy of multi-chain protein complex structure prediction improves, the challenge has shifted towards effectively navigating the vast complex universe to identify potential PPIs. Herein, we propose PPIretrieval, the first deep learning-based model for protein-protein interaction exploration, which leverages existing PPI data to effectively search for potential PPIs in an embedding space, capturing rich geometric and chemical information of protein surfaces. When provided with an unseen query protein with its associated binding site, PPIretrieval effectively identifies a potential binding partner along with …

Play Neuroball ! : Unleashing The Power Of Spherical Spiking Neural Networks, Renee Gagnon

Defensive Publications Series

This document presents a novel concept in artificial neural networks: the Spherical Spiking Neural Network (Spherical SNN). This approach combines the biological realism of spiking neural networks with a three-dimensional, spherical architecture that more closely mimics the structure of biological brains.

Defensive Publication: Single-Layer 256 Neuron Spike Neural Network With Standing Wave Activation, Renee Gagnon

Defensive Publications Series

This defensive publication details the innovative design and implementation of a single-layer 256 neuron Spike Neural Network (Spike NN) employing shapelets and a standing wave method for neural activation. Spike Neural Networks, inspired by biological neural systems, utilize discrete spikes for information processing, enhancing energy and computational efficiency. In this approach, shapelets—small, local patterns within time series data—are integrated to provide a new dimension of pattern recognition and neural activation. The standing wave method introduces a novel mechanism where interference patterns between outward and inward waves create areas of sustained neural activation. This model not only mimics the complex dynamics …

The Effect Of Lighting In Color In The Interior Space Of The Residential Unit, Abd Elbary Eldininy Abd Elbary Eldininy

Journal of Engineering Research

ABSTRACT: Humanity is spending more and more time indoors, both at work and at home - with studies showing that we now spend 87% of our lives indoors. Residential environ ments both positively affect the mood and well-being of its occupants, just as places with poor and uncomfortable lighting and colors can make life miserable. This is why we are interested in this issue. The importance of knowing the issues of lighting and colors in order to obtain a well thought-out interior design. The interior designer has the ability to control in the quality of lighting of various types, artificial …

Enhancing Daylight Using Sustainable Natural Lighting Techniques In Modern Architecture, سارة حسني شعلان أ.م.د/ لبني عبد الفتاح أغا

Journal of Engineering Research

Natural lighting is one of the basic criteria for the architectural design process. It is one of the most important data that contributes to the design of architectural spaces and the manifestation of aesthetic values. In light of the global technological development and the scientific and information revolution, the role of the architect comes in highlighting the importance of natural lighting and its positive role in human biology, and reducing effort and psychological pressure in the event of Its use is an alternative to artificial lighting, as it increases human efficiency and achievement at work, in addition to giving a …

The Impact Of Green Infrastructure On Urban Heat Island Phenomenon In Existing Cities, Neveen Youssef Azmy Basant Elsayed Abu-Farrag, Walaa Abou El-Haggag Mehanna

Journal of Engineering Research

Rapid urbanization and overpopulation, along with a lack of green space, led to an increase in air temperature, lowering the rate of thermal comfort in dense urban areas, decreasing air quality, and increasing the urban heat island (UHI) phenomenon, particularly in existing cities. As a result, the research aims to reduce the UHI effect and improve the thermal performance of existing Egyptian cities by adopting green infrastructure (GI) principles and demonstrating their effectiveness on the UHI phenomenon. This research concentrates on the UHI phenomenon as one of the environmental issues facing urbanization and includes a review of green infrastructure (GI) …

Using Recycled Materials Towards Sustainable, Eco-Friendly Building In Hot Regions – A Review, Mai W. Madkour Hosny A. Dewer, And Shaimaa M. Refaat

Journal of Engineering Research

Due to population growth and increased urban activity, there is a rise in waste production, which poses health and environmental risks. Additionally, the extraction and transportation of natural resources to places of employment require significant energy consumption, and the world has therefore moved to seek new alternatives away from traditional construction methods by recycling building materials such as concrete, brick, glass, wood, etc., or using new building materials such as rice straw, plastics, corks, etc., taking into account architectural design. The research is aimed at demonstrating that recycled materials have the potential to perform a better environmental performance by preserving …

Heritage Preservation In Egyptian Villages And Centers, Azza Elsakka Ahmed Abdalwahaab , Ebtehal Fady Shareef

Journal of Engineering Research

Heritage holds deep significance as a collective memory and a source of pride for any society. However, in today's world, it has evolved beyond its symbolic status and emerged as a crucial factor in human development across various dimensions. Preserving and restoring heritage has thus become an urgent issue that demands extensive cooperation between governments, international society, and community associations.

Eco-Urbanism: Integrating The Transformation Of Sustainability Into City Design, Mira Ibrahim Helmi

Journal of Engineering Research

Eco-Urbanism, as a contemporary approach to city design, strives to seamlessly embed sustainability into the very fabric of urban environments. This abstract delves into the fundamental principles & aspirations of Eco-Urbanism, illustrating its commitment to catalysing a paradigm shift that harmonizes ecological, economic, social dimensions within cities. In a world increasingly defined by urbanization and ecological challenges, Eco-Urbanism emerges as an imperative response to the imperative for sustainable urban planning. It envisions cities that are not merely centres of growth but are purposefully designed to coexist with and protect their natural surroundings, nurture economic vitality, and champion social inclusivity. Key …

Public Realm For Enhanced Quality Of Life :Interactive Spaces Combating Climate Change, Amal M . El- Ellithy , Mohamed M. Yossef , And Mai W. Madkour

Journal of Engineering Research

Currently, facing climate change stands as a crucial focus within architecture, urban planning and design .Urban design is constructive endeavor aimed at benefiting the public. The public realm that creates the environment for individuals and communities to effectively, safely, meaningfully and permanently lead their lives .For a prolonged duration the public realm have been formulated to accommodate severe climatic conditions .the reality persists that the essence of a signification public realm continue to be widely disregarded . The aim is to clarify how exceptional quality, effectively designed, and well-managed approaches can be beneficial to implement as a strategy for climate …