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Systematic Review Of Factors Related To Pm2.5 Exposure On The Risk Of Type 2 Diabetes Mellitus, Rifka Putri Salma, Laila Fitria Jul 2024

Systematic Review Of Factors Related To Pm2.5 Exposure On The Risk Of Type 2 Diabetes Mellitus, Rifka Putri Salma, Laila Fitria

Kesmas

Diabetes mellitus is a major public health problem in many countries, and most of them are type 2 diabetes mellitus (T2DM). Air pollution is thought to contribute to the T2DM incidence, and one of the most important pollutants is PM2.5. This study aimed to determine factors related to PM2.5 exposure and individual factors in increasing the risk of T2DM based on a systematic review. The PRISMA was used as a method of data collection and selection. Of 176 relevant articles identified and screened, 12 articles from various countries published in 2013-2021 were synthesized in this study. Results showed that long-term …

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Ambient Particulate Matter With Blood Pressure In Adult Women Living In Urban City, Nurusysyarifah Aliyyah, Haryoto Kusnoputranto, Bambang Wispriyono, Laila Fitria Jul 2024

Ambient Particulate Matter With Blood Pressure In Adult Women Living In Urban City, Nurusysyarifah Aliyyah, Haryoto Kusnoputranto, Bambang Wispriyono, Laila Fitria

Kesmas

Ambient air pollution, especially from fine particles, contributes to human mortality from cardiovascular and respiratory diseases, for which high blood pressure (BP) is a major modifiable risk factor. This study aimed to analyze the influence of ambient particulate matter (PM2.5) on the risk of high BP leading to hypertension. This study used a cross-sectional design on 118 adult women living in Central Jakarta, Indonesia. Participants were selected from a 1-km radius of the nearest air quality monitoring station with available data PM2.5. Linear regression was analyzed to examine the relationship between PM2.5 and systolic and diastolic BPs adjusted for potential …

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Health And Environmental Pollution: A Literature Review, Elsa Yuniarti, Levi Anatolia S.M. Exposto, Indang Dewata, Fitra Arya Dwi Nugraha, Alfitri Alfitri Jul 2024

Health And Environmental Pollution: A Literature Review, Elsa Yuniarti, Levi Anatolia S.M. Exposto, Indang Dewata, Fitra Arya Dwi Nugraha, Alfitri Alfitri

Kesmas

This study aimed to review various studies focusing on pollution that could adversely affect health, including sources, types, and mitigation efforts. The data used were obtained through a search on the Scopus website using the keywords "Health" AND "Pollution" from 2016 to 2023. Using these two keywords, 72 titles and abstracts of papers were successfully found. The results of this literature review were then analyzed with the assistance of NVivo 12 Pro, which grouped the findings based on their impact on health, reasons for pollution, types of pollution, and preventive measures. It was identified that the most common disease was …

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Data Mining Analysis With Orange In The Development Of Tuberculosis Among Diabetes Mellitus Patients, Malahayati Rusli Bintang, Adang Bachtiar, Cicilya Candi Jul 2024

Data Mining Analysis With Orange In The Development Of Tuberculosis Among Diabetes Mellitus Patients, Malahayati Rusli Bintang, Adang Bachtiar, Cicilya Candi

Kesmas

Prevention and treatment of diabetes will have a positive influence on tuberculosis (TB) since people may get TB because they have diabetes mellitus (DM). Recording and reporting through the TB Information System are not run optimally because of many factors. The information system must be strengthened to be used by private health facilities. This study used secondary data from the 2013 and 2018 Indonesian Basic Health Research (IBHR). The data was analyzed univariately and analyzed further using Orange Data Mining Tools to test the screening tool model used to predict TB in diabetic individuals. The total sample in this study …

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New Approach To Mapping Regional Vulnerability In Controlling Tuberculosis Disease In Indonesia, Maria Holly Herawati, Asep Hermawan, Dasuki Dasuki, Hadi Supratikta, Al Asyary, M Rokhis Khomarudin, Muhammad Priyatna, Raflizar Raflizar, Kristina Kristina, Noer Endah Pracoyo, Dina Bisara, Cahya Tri Purnami, Mentari Nur Farida Suteja, Yusrial Bachtiar, Noor Edi Widya Sukoco, Doni Lasut Jul 2024

New Approach To Mapping Regional Vulnerability In Controlling Tuberculosis Disease In Indonesia, Maria Holly Herawati, Asep Hermawan, Dasuki Dasuki, Hadi Supratikta, Al Asyary, M Rokhis Khomarudin, Muhammad Priyatna, Raflizar Raflizar, Kristina Kristina, Noer Endah Pracoyo, Dina Bisara, Cahya Tri Purnami, Mentari Nur Farida Suteja, Yusrial Bachtiar, Noor Edi Widya Sukoco, Doni Lasut

Kesmas

Tuberculosis (TB) in Indonesia is still a health problem. The TB prevalence in Indonesia ranks second in the world after India in 2023. Regional factors, inadequate healthcare facilities, and limited resources (financial, human, and infrastructure) are challenges requiring innovation to help the government control TB. TB eradication efforts need to be made with a comprehensive and effective approach. One method used is to look at the vast territory of Indonesia, therefore, mapping the TB disease vulnerability is a highly recommended method. The use of a Geographic Information System is expected to help map the TB vulnerability areas in Indonesia. Given …

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Adaptative Survival Of Aspergillus Fumigatus To Echinocandins Arises From Cell Wall Remodeling Beyond Β−1,3-Glucan Synthesis Inhibition, Malitha C. Dickwella Widanage, Isha Gautam, Daipayan Sarkar, Frederic Mentink-Vigier, Josh V. Vermaas, Shi You Ding, Andrew S. Lipton, Thierry Fontaine, Jean Paul Latgé, Ping Wang, Tuo Wang Jul 2024

Adaptative Survival Of Aspergillus Fumigatus To Echinocandins Arises From Cell Wall Remodeling Beyond Β−1,3-Glucan Synthesis Inhibition, Malitha C. Dickwella Widanage, Isha Gautam, Daipayan Sarkar, Frederic Mentink-Vigier, Josh V. Vermaas, Shi You Ding, Andrew S. Lipton, Thierry Fontaine, Jean Paul Latgé, Ping Wang, Tuo Wang

School of Graduate Studies Faculty Publications

Antifungal echinocandins inhibit the biosynthesis of β−1,3-glucan, a major and essential polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins against the pathogen Aspergillus fumigatus is limited. Here, we use solid-state nuclear magnetic resonance (ssNMR) and other techniques to show that echinocandins induce dynamic changes in the assembly of mobile and rigid polymers within the A. fumigatus cell wall. The reduction of β−1,3-glucan induced by echinocandins is accompanied by a concurrent increase in levels of chitin, chitosan, and highly polymorphic α−1,3-glucans, whose physical association with chitin maintains cell wall integrity and modulates water permeability. The rearrangement of …

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Alternative Therapies Of The Banjar People For Children With Fevers, Esme Anggeriyane, Hamzah Hamzah, Nurhikmah Nurhikmah Jul 2024

Alternative Therapies Of The Banjar People For Children With Fevers, Esme Anggeriyane, Hamzah Hamzah, Nurhikmah Nurhikmah

Jurnal Keperawatan Indonesia

Fevers often occur in children under five years of age due to the immature formation of their immune systems. Such fevers signify that something unusual is happening in the body, often due to illness. Parents conduct various management techniques, such as medical or traditional treatments, based on their beliefs. Banjar society has a health culture known as bapidara, which is used to treat children with fevers presumably attributable to supernatural disturbances. This exploratory research aimed to discover what alternative therapies the Banjar people use to treat children with fevers. This qualitative study used a transcendental phenomenological design. Data collection was …

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Dinamika Kepribadian Johan De Vries Dalam Film De Oost (2020) Karya Jim Taihuttu, Raditya Triandi, Barbara Elisabeth Lucia Pesulima Jul 2024

Dinamika Kepribadian Johan De Vries Dalam Film De Oost (2020) Karya Jim Taihuttu, Raditya Triandi, Barbara Elisabeth Lucia Pesulima

Multikultura

Indonesia telah memproklamasikan kemerdekaannya pada 17 Agustus 1945. Pasca kemerdekaan, Belanda masih menduduki beberapa wilayah di Indonesia. Kedudukan Belanda di Indonesia sangat historis dan sudah banyak produser film yang menggunakan latar belakang kolonialisme Belanda di Indonesia. Salah satunya adalah film De Oost (2020) yang merupakan film berlatar belakang era pendudukan Belanda pasca kemerdekaan Republik Indonesia pada tahun 1946. Film ini menceritakan mengenai tokoh utama bernama Johan de Vries yang merupakan seorang tentara dan ditugaskan di Semarang. Penelitian ini membahas dinamika kepribadian Johan de Vries menggunakan teori psikoanalisis Sigmund Freud dan teori kepribadian William Mc Dougall. Metodologi yang digunakan dalam penelitian …

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Increasing The Robustness Of Machine Learning By Adversarial Attacks, Gourab Mukhopadhyay Jul 2024

Increasing The Robustness Of Machine Learning By Adversarial Attacks, Gourab Mukhopadhyay

Theses and Dissertations

By perturbation or physical attacks any machine can be fooled into predicting something else other than the intended output. There are training data based on which the model is trained to predict unknown things. The objective was to create noises and shades of different levels on the images and do experiments for measuring accuracy and making the model classify the traffic signs. When it comes to adding shades to the pictures, pixels were modified for three different layers of the pictures. The experiment also shows that with the shadows getting deeper, the accuracies drop significantly. Here, some changes in pixels …

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Suicide And Its Nexus: A Theoretical Reconstruction Of Suicide, Nastiti Soegeng Lestari Jul 2024

Suicide And Its Nexus: A Theoretical Reconstruction Of Suicide, Nastiti Soegeng Lestari

Masyarakat: Jurnal Sosiologi

In Indonesia, suicide research has largely overlooked structural factors at the meso and macro levels, whether as primary causes, contributing factors, or considerations for prevention strategies. The dominance of psychological and psychiatric approaches has marginalized sociological perspectives, limiting a more holistic understanding of suicide. Existing heuristic models primarily frame suicide as a consequence of mental health disorders or economic conditions, reinforcing a dichotomy: one perspective views suicide as a psychological and/or psychiatric phenomenon, while the other treats it as a sociological fact. However, suicide encompasses a far more complex reality that transcends this binary. This study offers a comprehensive theoretical …

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The Gender Ideology Of State Ibuism And Women’S Roles In Care Practices At The Rawa Panjang Waste Bank, Bojonggede, Bogor, Marini Purnamasari Jul 2024

The Gender Ideology Of State Ibuism And Women’S Roles In Care Practices At The Rawa Panjang Waste Bank, Bojonggede, Bogor, Marini Purnamasari

Masyarakat: Jurnal Sosiologi

This article examines women's involvement in community-based waste management through the Waste Bank program. It argues that women’s participation in managing waste banks reflects the state’s gender ideology, which reinforces the reproduction of female labor and caregiving roles within society. Applying Suryakusuma’s (2011) concept of state ibuism, this study explores women’s roles in the Waste Bank program in Rawa Panjang, Citayam, Bogor Regency. Employing a qualitative approach, it utilizes methods such as observation, focus group discussions (FGDs), photoelicitation interviews, and in-depth interviews. The findings indicate that the Waste Bank program in Rawa Panjang serves as a contemporary manifestation of state …

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Bunuh Diri Dan Untai Problematikanya: Sebuah Rekonstruksi Teoritik Atas Bunuh Diri, Nastiti Soegeng Lestari Jul 2024

Bunuh Diri Dan Untai Problematikanya: Sebuah Rekonstruksi Teoritik Atas Bunuh Diri, Nastiti Soegeng Lestari

Masyarakat: Jurnal Sosiologi

In Indonesia, suicide research has largely overlooked structural factors at the meso and macro levels, whether as primary causes, contributing factors, or considerations for prevention strategies. The dominance of psychological and psychiatric approaches has marginalized sociological perspectives, limiting a more holistic understanding of suicide. Existing heuristic models primarily frame suicide as a consequence of mental health disorders or economic conditions, reinforcing a dichotomy: one perspective views suicide as a psychological and/or psychiatric phenomenon, while the other treats it as a sociological fact. However, suicide encompasses a far more complex reality that transcends this binary. This study offers a comprehensive theoretical …

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Library Disaster Preparedness In Southeast Asia: A Systematic Review, Azraai Abidin, Mohd Najib Abdullah, Noor Faezah Shaari, Nur Shurbaniah Saad Jul 2024

Library Disaster Preparedness In Southeast Asia: A Systematic Review, Azraai Abidin, Mohd Najib Abdullah, Noor Faezah Shaari, Nur Shurbaniah Saad

ASEAN Journal of Community Engagement

This systematic review, which follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, examines the current state of disaster preparedness in libraries across Southeast Asia. It evaluates existing research using four core emergency preparedness rule elements: risk assessment and planning, the communication plan, policies and procedures, and training and testing. While an initial search identified 488 potential studies, only seven met the strict criteria; these seven studies were from Indonesia, Malaysia, and the Philippines. This indicates either a significant gap in library readiness or a lack of comprehensive research on the subject. The results show that most …

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Phylogenetic Analysis Of Anthropomorphic Rock Art: A Study Of Material Culture Evolution, Muhammad Faisal Chair, Ali Akbar Jul 2024

Phylogenetic Analysis Of Anthropomorphic Rock Art: A Study Of Material Culture Evolution, Muhammad Faisal Chair, Ali Akbar

International Review of Humanities Studies

This paper provides an explanation of the application of phylogenetic analysis, derived from biology, to be applied in archaeology with the aim of observing evolutionary phenomena, the development of ideas, and the dissemination of ideas from material culture. Phylogenetics will be applied to data on anthropomorphic motifs at five rock art sites in West Sumatra: Gua Lidah Air, Gua Runjo, Ngalau Tompok Syohiah, Batu Basurek, and Gua Basurek. The main stages in this analysis involve collecting representative data in the category of distinctive values from each rock art site. Distinctive values data is obtained through observation and identification of morphological …

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The Philosophy Of Spirits Purification In The Ritual Entas-Entas In Wonotoro Village As The Identity Of The Tengger Community, Turita Indah Setyani, Titik Pudjiastuti, Rias Suharjo, Mamlahatun Buduroh, Mu’Jizah Mu’Jizah, Dwi Rahmawanto Jul 2024

The Philosophy Of Spirits Purification In The Ritual Entas-Entas In Wonotoro Village As The Identity Of The Tengger Community, Turita Indah Setyani, Titik Pudjiastuti, Rias Suharjo, Mamlahatun Buduroh, Mu’Jizah Mu’Jizah, Dwi Rahmawanto

International Review of Humanities Studies

This paper examines the Ritual Entas-entas as a purification ceremony for spirits in Wonotoro Village, Tengger. The ritual originates from a manuscript believed to aid in purifying the spirits of deceased family members. This ritual has been passed down orally. However, the manuscript serving as the reference for the ritual can no longer be traced. The issue is, how the sustainability of the Ritual Entas-entas in Wonotoro Village, Tengger? The research aims to demonstrate that the Tengger community possesses a collective memory strength and high adherence to traditional rules as part of everyday religious practice. The research utilizes ethnographic methodology …

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Pengaruh Karakteristik Rumah Tangga Terhadap Kejadian Kematian Maternal Di Pulau Papua, Intan Putri Utami, Yuliagnis Transver Wijaya Jul 2024

Pengaruh Karakteristik Rumah Tangga Terhadap Kejadian Kematian Maternal Di Pulau Papua, Intan Putri Utami, Yuliagnis Transver Wijaya

Jurnal Ekonomi Kependudukan dan Keluarga

Maternal health and life during pregnancy, childbirth, and the postpartum period are very important in determining the growth and future development of the birth generation. SDG indicators express the global seriousness of this effort, aiming to reduce the maternal mortality ratio (MMR) to less than 70 per 100,000 live births by 2030. However, according to the Long Form SP2020, Indonesia still has 189 deaths per 100,000 live births. Papua and West Papua are the two provinces with the worst MMR achievements, with 565 and 343 deaths per 100,000 live births, respectively. Therefore, this research will provide general overview and identify …

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Chemical Recycling Of Bio-Based Polyurethane Foams: Evaluating Bio-Based Glycols In Comparison To Petroleum-Based Glycols, Anirudh Thorbole Mr. Jul 2024

Chemical Recycling Of Bio-Based Polyurethane Foams: Evaluating Bio-Based Glycols In Comparison To Petroleum-Based Glycols, Anirudh Thorbole Mr.

Electronic Theses & Dissertations

The paradigm shift towards bio-based polyurethane foams (bio-PUF) has significantly increased post-consumer waste. To address this issue, this research represents a novel approach to enhance sustainable development in the recycling industry by replacing traditional petroleum-based glycols with sustainable bio-based alternatives. This study explores the glycolysis of bio-PUF using bio-based SG-522 glycol and polyethylene glycol (PEG) for comparison. The findings from this research as outlined, reveal no significant differences in depolymerization time between the two glycols, achieving proper depolymerization and high recovery yields of over 95% after solvent purification. Comprehensive FT-IR and NMR analyses confirmed the successful degradation of bio-PUF and …

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Pendidikan Dan Penggunaan Internet Menurunkan Kemiskinan Di Banten, Hudaya Latuconsina, Khusaini Khusaini, Sri Jaya Lesmana Jul 2024

Pendidikan Dan Penggunaan Internet Menurunkan Kemiskinan Di Banten, Hudaya Latuconsina, Khusaini Khusaini, Sri Jaya Lesmana

Jurnal Ekonomi dan Pembangunan Indonesia

In the last decade, poverty patterns in Banten Province have tended to increase. There have been many poverty alleviation programs provided by governments at all levels that focus on education, social security, and so on. This research aims to examine the role of education, internet use, and internet access on poverty in Banten. Using static and robust panel analysis shows that education contributes significantly to poverty reduction in Banten’s districts/municipalities, as does the use of the internet for information/news and social media. On the contrary, internet access harmed on regency/municipality poverty in Banten. This research contributed to providing academic information …

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Excited State Processes In Radical Elaborated Platinum Donor-Acceptor Complexes, Sangita Paudel Jul 2024

Excited State Processes In Radical Elaborated Platinum Donor-Acceptor Complexes, Sangita Paudel

Chemistry and Chemical Biology ETDs

Organo-transition metal complexes are being widely studied to understand their photophysical properties for their wide range of applications as efficient emitters in organic light emitting diodes (OLEDs), light emitting electrochemical cells (LEECs), etc. Cyclometalated organo-transition metal complexes such as cyclometalated square planar platinum(II) complexes are becoming suitable candidates for such applications because of their highly efficient luminescence. Understanding the excited properties of such complexes is useful in designing highly efficient and color tunable phosphors with desired excited state lifetimes. We aim to explore the influence of radical substituents on electronic structure, luminescence quantum efficiencies, and excited state lifetimes by synthesizing …

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Determinan Ekspor Kopi Indonesia: Berpengaruhkah Fta?, Fikri Aldi Dwi Putro, Lovina Aresta Putri, Gunawan Prawira, Sahara Sahara Jul 2024

Determinan Ekspor Kopi Indonesia: Berpengaruhkah Fta?, Fikri Aldi Dwi Putro, Lovina Aresta Putri, Gunawan Prawira, Sahara Sahara

Jurnal Ekonomi dan Pembangunan Indonesia

Indonesia has initiated trade liberalization to boost the coffee export performance in the international market through trade agreements (FTA). However, Indonesian coffee export performance tends to decline. This study aims to analyze the effect of Indonesia’s FTA with its trading partners and other determinants of Indonesian coffee exports. This research employs a modified export approach gravity model with PPML estimation. The result shows that the FTA implementation generally can promote Indonesian coffee export, implying the export creation effect. Therefore, inward and outward-looking strategies are necessary to further boost the export creation effect on Indonesian coffee.

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Molecular Insights Into Propylthiouracil As A Thyroid Peroxidase Inhibitor: A Computational Study Approach, Dwi Anita Suryandari, Luluk Yunaini, Hadi Sunaryo, Khaerunissa Anbar Istiadi, Irandi Putra Pratomo Jul 2024

Molecular Insights Into Propylthiouracil As A Thyroid Peroxidase Inhibitor: A Computational Study Approach, Dwi Anita Suryandari, Luluk Yunaini, Hadi Sunaryo, Khaerunissa Anbar Istiadi, Irandi Putra Pratomo

Indonesian Journal of Medical Chemistry and Bioinformatics

Thyroid peroxidase (TPO) is a crucial enzyme in the biosynthesis of thyroid hormones, catalyzing the iodination of tyrosine residues in thyroglobulin and the coupling of iodotyrosines to form thyroxine (T4) and triiodothyronine (T3). Propylthiouracil (PTU) is an antithyroid drug commonly used to manage hyperthyroidism by inhibiting TPO. Understanding the molecular interactions between TPO and PTU can provide insights into the inhibitory mechanisms and guide the design of more effective antithyroid medications. Objective: This study aims to elucidate the binding interactions between TPO and PTU through molecular docking, providing a detailed understanding of how PTU inhibits TPO activity. Methods: …

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Natural Dye Of Indigofera Tinctoria For Textile Industry, Nor Isnaeni Dwi Arista, Sandra Arifin Aziz, Ani Kurniawati Jul 2024

Natural Dye Of Indigofera Tinctoria For Textile Industry, Nor Isnaeni Dwi Arista, Sandra Arifin Aziz, Ani Kurniawati

Journal of Environmental Science and Sustainable Development

The examination of sustainability within the textile industry necessitates an exploration of various environmental pollution issues. This study aims to tackle challenges in the synthetic dye industry by reviewing past research on textile dyeing, providing scientific insights, identifying patterns, and highlighting research gaps. It is hypothesized that the cultivation of Indigofera tinctoria with optimized NPK fertilization can significantly enhance its growth and yield, contributing to sustainable natural dye production. Using a mixed-methods approach, this study integrated bibliometric analysis of 1320 Scopus articles with field experiments. The bibliometric analysis, conducted with Vos Viewer software, identifies India and the United States as …

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Online Media Sentiment Analysis For Us Oysters, Taylor L. Bradford, Kwamena Quagrainie Jul 2024

Online Media Sentiment Analysis For Us Oysters, Taylor L. Bradford, Kwamena Quagrainie

Department of Agricultural Economics Faculty Publications

Sentiment analysis, a form of data analytics, utilises information from online discussions, reviews, and social media posts to assess consumer sentiments. This study utilised data collected from social media using online listening procedures to assess online sentiments on oysters from January 2019 through December 2022. The analysis utilises machine learning algorithms to extract consumer sentiments, opinions, and demands from online chatter from different online domains. The online sentiments are determined as positive, negative, or neutral based on their word choice, tone, and context. The information provided gives insights into perception, which is valuable information for oyster producers, seafood industry stakeholders, …

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Draft Genome Sequences Of An Enterobacter Hormaechei And Providencia Rettgeri Isolated From The Urine Of A Male Experiencing A Catheter-Associated Urinary Tract Infection, Helen Appleberry, Michaela Brady, Samantha Webster, Alan J. Wolfe, Catherine Putonti, Alex Kula Jul 2024

Draft Genome Sequences Of An Enterobacter Hormaechei And Providencia Rettgeri Isolated From The Urine Of A Male Experiencing A Catheter-Associated Urinary Tract Infection, Helen Appleberry, Michaela Brady, Samantha Webster, Alan J. Wolfe, Catherine Putonti, Alex Kula

Biology: Faculty Publications and Other Works

Catheter-associated urinary tract infections (CAUTIs) can be caused by a variety of microbes. Here, we describe the draft genome assemblies of two species—Enterobacter hormaechei and Providencia rettgeri—purified from the catheterized urine sample of a male diagnosed with a CAUTI.

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Abstract Book Of The 16th Indonesian Occupational Medicine Update (Iomu) Jul 2024

Abstract Book Of The 16th Indonesian Occupational Medicine Update (Iomu)

Occupational and Environmental Medicine Journal of Indonesia

Jakarta, Indonesia, 2nd March to 4th March 2024

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Adaptation Of The Protein Misfolding Cyclic Amplification (Pmca) Technique For The Screening Of Anti-Prion Compounds, Katherine Do, Rebeca Benavente, Celso S G Catumbela, Uffaf Khan, Carlos Kramm, Claudio Soto, Rodrigo Morales Jul 2024

Adaptation Of The Protein Misfolding Cyclic Amplification (Pmca) Technique For The Screening Of Anti-Prion Compounds, Katherine Do, Rebeca Benavente, Celso S G Catumbela, Uffaf Khan, Carlos Kramm, Claudio Soto, Rodrigo Morales

Faculty, Staff and Student Publications

Prion diseases result from the misfolding of the physiological prion protein (PrPC) to a pathogenic conformation (PrPSc). Compelling evidence indicates that prevention and/or reduction of PrPSc replication are promising therapeutic strategies against prion diseases. However, the existence of different PrPSc conformations (or strains) associated with disease represents a major problem when identifying anti-prion compounds. Efforts to identify strain-specific anti-prion molecules are limited by the lack of biologically relevant high-throughput screening platforms to interrogate compound libraries. Here, we describe adaptations to the protein misfolding cyclic amplification (PMCA) technology (able to faithfully replicate PrPSc strains) that increase its throughput to facilitate the …

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Phase Ii Study Of Talazoparib In Advanced Cancers With Brca1/2, Dna Repair, And Pten Alterations, Sarina A Piha-Paul, Chieh Tseng, Cheuk Hong Leung, Ying Yuan, Daniel D Karp, Vivek Subbiah, David Hong, Siqing Fu, Aung Naing, Jordi Rodon, Milind Javle, Jaffer A Ajani, Kanwal P Raghav, Neeta Somaiah, Gordon B Mills, Apostolia M Tsimberidou, Xiaofeng Zheng, Ken Chen, Funda Meric-Bernstam Jul 2024

Phase Ii Study Of Talazoparib In Advanced Cancers With Brca1/2, Dna Repair, And Pten Alterations, Sarina A Piha-Paul, Chieh Tseng, Cheuk Hong Leung, Ying Yuan, Daniel D Karp, Vivek Subbiah, David Hong, Siqing Fu, Aung Naing, Jordi Rodon, Milind Javle, Jaffer A Ajani, Kanwal P Raghav, Neeta Somaiah, Gordon B Mills, Apostolia M Tsimberidou, Xiaofeng Zheng, Ken Chen, Funda Meric-Bernstam

Faculty, Staff and Student Publications

Cancer cells with BRCA1/2 deficiencies are sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. We evaluated the efficacy of talazoparib in DNA-Damage Repair (DDR)-altered patients. In this phase II trial, patients were enrolled onto one of four cohorts based on molecular alterations: (1) somatic BRCA1/2, (2) other homologous recombination repair pathway, (3) PTEN and (4) germline BRCA1/2. The primary endpoint was a clinical benefit rate (CBR): complete response, partial response or stable disease ≥24 weeks. 79 patients with a median of 4 lines of therapy were enrolled. CBR for cohorts 1-4 were: 32.5%, 19.7%, 9.4% and 30.6%, respectively. PTEN mutations correlated …

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Cherry Powdery Mildew In Utah, Marion Murray, Christina Lilligren, Megan Kast Jul 2024

Cherry Powdery Mildew In Utah, Marion Murray, Christina Lilligren, Megan Kast

All Current Publications

This fact sheet provides information on powdery mildew, a common problem in commercial tart and sweet cherry orchards in Utah and throughout the western U.S. Hosts, disease biology, symptoms and signs, and management are covered.

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Exploring The Vulnerability Of Small-Scale Fisherfolks In Selected Barangays, Arlon Ponce Cadiz, Blesshelyn Guevarra Sanchez, Eden Vela Evangelista Jul 2024

Exploring The Vulnerability Of Small-Scale Fisherfolks In Selected Barangays, Arlon Ponce Cadiz, Blesshelyn Guevarra Sanchez, Eden Vela Evangelista

Journal of Environmental Science and Sustainable Development

Small-scale fisherfolks contributed to the livelihood and economic aspects of the fishery sector in the region. However, they are vulnerable regarding potential risks and threats caused by various conditions. This study explored the vulnerability of fifty-two small-scale fisherfolks selected from six barangays near Laguna's Northern West Bay, Philippines. The case study design guided the data collection from multiple sources, including survey questionnaires, unstructured interviews, and document analysis for triangulation and analysis of fisherfolks' exposure, sensitivity, and adaptive capacity. Results show that there are indicators that contribute to the vulnerability of fisherfolk in terms of exposure, which involves hydrometeorological hazards, water …

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Suitability Assessment Of Groundwater Quality For Drinking Purposes, Md. Zahidul Islam, M. G. Mostafa Jul 2024

Suitability Assessment Of Groundwater Quality For Drinking Purposes, Md. Zahidul Islam, M. G. Mostafa

Journal of Environmental Science and Sustainable Development

The groundwater status of Northwestern Bangladesh is a complex and challenging issue due to its arid and semi-arid climates, increasing population, overexploitation for domestic and irrigation purposes, lack of adequate rainfall, and limited water resources. The study aimed to assess the suitability and health risk of groundwater quality for drinking purposes. A total of one hundred groundwater samples were collected from shallow tubewells in two seasons, the monsoon (MON) and post-monsoon (POM), in northwestern Bangladesh (Ganges River basin) and analyzed using standard methods of analysis (Atomic adsorption spectrometry, UV-visible spectrometry, graphite, ion chromatography). The trends of predominant cations were Ca2+ …

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