Digital Commons Network^™

Cystic Fibrosis Pathogens Persist In The Upper Respiratory Tract Following Initiation Of Elexacaftor/Tezacaftor/Ivacaftor Therapy, Yasmin K. Hilliam, Catherine R. Armbruster, Glenn J. Rapsinski, Christopher W. Marshall, John Moore, Junu Koirala, Leah Krainz, Jordan R. Gaston, Vaughn S. Cooper, Stella E. Lee, Jennifer M. Bomberger

Biological Sciences Faculty Research and Publications

Elexacaftor/tezacaftor/ivacaftor (ETI) therapy has revolutionized the treatment of cystic fibrosis (CF) for most affected individuals but the effects of treatment on sinus microbiota are still unknown. Changes to the airway microbiota in CF are associated with disease state and alterations to the bacterial community after ETI initiation may require changes to clinical management regimens. We collected sinus swab samples from the middle meatus in an observational study of 38 adults with CF and chronic rhinosinusitis (CRS) from 2017 to 2021 and captured the initiation of ETI therapy. We performed 16S and custom amplicon sequencing to characterize the sinus microbiota pre- …

Impact Of Pre-Harvest Fungicide Application On The Storage Performance Of Tomato Fruits, Zhifu Lan, Jing Huang, Komivi S. Akutse, Yongwen Lin

All Peer-Reviewed Publications

To examine the impact of pre-harvest fungicide applications on the postharvest storage performance of tomato fruits, we measured the lycopene content, hardness, soluble solids content, rotting rate, and weight loss rate of the fruits, as well as conducted a sensory assessment. Protective and systematic fungicides were sprayed on tomatoes 20 days before harvest in order to prevent rotting and weight loss during storage. Our findings showed that, the fungicide-treated tomatoes had a significantly lower rotting rate of 16.00% and a weight loss rate of 3.96%. However the control group experienced 65.33% rotting rate and 6.90% weight loss rate on 12th …

High-Dose Intravenous Vitamin C Combined With Docetaxel In Men With Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase Ii Trial, Channing Paller, Marianna Zahurak, Adel Mandl, Nicole Metri, Aliya Lalji, Elisabeth Heath, William Kelly, Christopher Hoimes, Pedro Barata, Jason Taksey, Dominique Garrison, Kartick Patra, Ginger Milne, Nicole Anders, Julie Nauroth, Jennifer Durham, Catherine Marshall, Mark Markowski, Mario Eisenberger, Emmanuel Antonarakis, Michael Carducci, Samuel Denmeade, Mark Levine

Department of Medicine Faculty Papers

UNLABELLED: High-dose intravenous vitamin C (HDIVC) administered to produce pharmacologic concentrations shows promise in preclinical models and small clinical trials, but larger prospective randomized trials are lacking. We evaluated the clinical benefit of combining HDIVC with docetaxel in patients with progressive metastatic castration-resistant prostate cancer (mCRPC). In this double-blind, placebo-controlled phase II trial, 47 patients were randomized 2:1 to receive docetaxel (75 mg/m2 i.v.) with either HDIVC (1 g/kg) or placebo. Coprimary endpoints were PSA50 response and adverse event rates. Secondary endpoints included overall survival, radiographic progression-free survival, and quality of life measured using the Functional Assessment of Cancer Therapy-Prostate …

Experimental And Computational Investigation Of Green Laser Propagation Through Turbulent Medium In A Water Tank, Richard Owusu Adansi

Open Access Theses & Dissertations

Turbulence medium poses significant challenges to the propagation of laser beams, impacting applications such as free-space optical communication, remote sensing, and laser weapons systems. Therefore, comprehending and mitigating turbulence effects are vital for enhancing the performance of these systems. Analysis of a strong turbulence impact on electromagnetic wave propagation requires extensive knowledge of the Earth's atmospheric and Oceanic phenomena and Maxwell's electromagnetic theory of light as a propagating wave of electric and magnetic fields. Optical systems' propagation often encounters Strong Turbulence, causing interference and diffraction. Nonetheless, light propagation through randomly fluctuating media has been an exciting and active area of …

Development Of 3d Human Cardiovascular And Cancer Tissue Model Within A Self-Driven Microfluidic Platform For Preclinical Drug Screening, Aibhlin Alexis Esparza

Open Access Theses & Dissertations

According to the American Heart Association and World Health Organization, cardiovascular diseases (CVDs) are the leading cause of death worldwide. Monolayer cell culture (2D) and animal models are conventional methods to study CVDs, however, they limit researcherâ??s ability to simulate the human cardiovascular cellular microenvironments and accurate predication of pharmaceutical drug responses. Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs), biomaterials, and microfluidic technologies can be combined to create a controlled, reproducible 3D platform to study physiologically-relevant cellular responses to biochemical and physical changes in the microenvironment. My dissertation work demonstrates the development of novel self-driven microfluidic devices designed with …

Interpretations Of Aesthetic Experience And Its Enactment In High School Visual Arts Education, Kenneth Albert Dore

Open Access Theses & Dissertations

This dissertation sought to identify interpretations of Aesthetic Experience (AE) of high school visual arts teachers and purposes of its facilitation in their classrooms. Five high school visual arts teachers within a large school district in West Texas were interviewed. A qualitative Hybrid Phenomenological Method was utilized to analyze the data consisting of a descriptive and an interpretive approach. The descriptive approach highlighted common and unique characteristics of aesthetic experience as interpreted by the teachers. An interpretive approach was also employed utilizing Aesthetic Critical Pedagogy, Feminist Theory, and Aesthetic Theory frameworks along with my 20-years-experience as a visual arts teacher. …

Of Cells And Tissues: Identifying The Elements Of A Diabetic Cardiac In Vitro Study Model, Ivana Hernandez

Open Access Theses & Dissertations

This study aimed to elucidate the impact of advanced glycation end products (AGEs) and glucose shock on cardiomyocyte viability, gene expression, cardiac biomarkers, and cardiac contractility. Firstly, AGEs were generated in-house, and their concentration was confirmed using absorbance measurements. AC16 cardiomyocytes were then exposed to varying doses of AGEs, resulting in dose-dependent decreases in cell viability. The maximum tolerated dose of AGEs was determined, revealing significant downregulation of the cardiac gene gap junction alpha 1 (GJA1). Furthermore, the study assessed the effects of AGEs, glucose shock, and their combination on biomarkers, cardiac myosin heavy chain (MHC), and connexin-43 (Cx-43) in …

Flow-Shop Scheduling Optimization Through Discrete-Event Simulation And Neural Networks., Jesus Ricardo Herrera Garfio

Open Access Theses & Dissertations

Industrial developments over the past few decades have transformed manufacturingprocesses, emphasizing the necessity for efficient scheduling systems. The shift from manual scheduling to automated and optimized systems has underscored the need for innovative approaches to improve production efficiency. Scheduling optimization of manufacturing systems is critical to improve operational efficiency. Typically, these scheduling problems become challenging because they involve coordinating various production tasks, resource management, and makespan minimization. These challenges are particularly evident in flow-shop manufacturing systems, where the operation sequencing significantly impacts overall performance. The main objective of this manuscript is to present the methodology followed to optimize the schedule …

Signatures Of Selection, Gene Flow, And Genetic Drift On The Genomes Of A Recent Avian Radiation, Flor Brigitte Hernandez Camacho

Open Access Theses & Dissertations

Speciation is not a discrete event but rather a gradual process that occurs along a continuum. Initially, populations remain genetically and reproductively connected, but they become reproductively isolated as the process of speciation progresses. Advances in DNA sequencing technology has helped our understanding of the processes that contribute to changes in the genetic composition of populations over the progression of speciation, also known as drivers of evolution (i.e. genetic drift, mutation, selection, and gene flow). Among them, hybridization, or the interbreeding between distinct lineages, is increasingly recognized as a natural process that can have significant consequences to the speciation process. …

Decision-Making In Rats: Effects Of Drug Abuse, Safa Binte Hossain

Open Access Theses & Dissertations

Decision-making is a critical cognitive function, often impaired by substance abuse. Understanding the underlying mechanisms in both human and animal models is essential for developing effective treatments. This thesis aims to study approach-avoid decision-making in rats and focuses on the impacts of oxycodone self-administration and alcohol abuse on approach-avoid decision-making.We hypothesize that oxycodone self-administration will alter decision-making in female rats, revealing sex differences and distinct psychometric functions, alcohol habituation will similarly affect decision-making in male rats. The study involved 23 Long Evans rats (11 males and 12 females) for decision-making behavioral study connecting multiple levels of rewards and costs combinations. …

Staying Fresh: Unconventional Approaches Towards Advancing Energy Sustainability, Water Resources, And Community Resiliency In The Southwestern United States, Judith Hoyt

Open Access Theses & Dissertations

This dissertation addresses critical challenges in urban heat management, sustainable energy resource utilization, and water quality communication through three studies. Study 1 investigates the impact of roof color on urban heat islands in Tucson, Arizona where approximately 70% of roofs display high albedo (i.e., light) colors. Energy consumption simulations conducted indicate that converting dark- to light-colored roofs could save Tucson approximately $1,400,000 annually in energy costs, highlighting the potential of cool roofs for energy savings and improved thermal comfort. Study 2 assesses the sources of lithium in subsurface waters in West Texas and South Central New Mexico. Water chemistry data …

Establishment Of A Novel Prairie Vole (Microtus Ochrogaster) Sars-Cov-2 Infection And Transmission Model, Stephanie Rebecca Kehl

Open Access Theses & Dissertations

Considering that the number of SARS-CoV-2 cases and deaths continues to increase three years after the onset of the pandemic, the need for animal models to study disease pathology and test antiviral effectiveness remains paramount. Prairie voles offer unique advantages as an infection model, such as mirroring human social behavior, including pair bonding and biparental offspring rearing, having inducible estrus and ovulation cycles, and not being overly domesticated. Based on the sequence homology of the vole ACE2 receptor to that of other species that are susceptible to SARS-CoV-2, such as the ferret and hamster, we hypothesized that the vole ACE2 …

Method Development For The Quantification Of Critically Valuable Elements In Permian Basin Produced Waters, Carley Oliver

Open Access Theses & Dissertations

Produced waters (PW) are a major byproduct of the oil and gas industrial hydraulic fracturing processes that create a major waste disposal issue with a need for disposal, treatment, and reuse method developments. The current primary disposal method is subsurface injection, which can lead to high pressures in the subsurface. PWs are often highly saline from mineral leaching due to long residence in subsurface reservoirs. According to the USGS National Minerals Information Center, bromine, calcium chloride, iodine, lithium, magnesium, and sodium chloride have been found in and extracted from these domestic subsurface brines, suggesting that there may be other economically …

Ecological, Climatic, And Geomorphic Controls Of The Transport And Fate Of Co2 In Coastal Arctic Aquatic Ecosystems, Alina Spera

Open Access Theses & Dissertations

Due to the ecological and physical responses of arctic tundra to warming, organic carbon (C) stored in frozen permafrost soils is increasingly at risk of mineralization and export to aquatic systems, the coast, and atmosphere. Although many coastal aquatic systems in the Arctic are likely net sources of CO2 to the atmosphere, little is known about the drivers of inorganic C flux and how these systems contribute to regional C budgets. This dissertation addresses several lapses in our understanding of coastal inorganic C dynamics in arctic Alaska via three data chapters. In chapter 2, I examine seasonal and regional variability …

Neural Networks For Decisions Under Uncertainty, Edwin Tomy George

Open Access Theses & Dissertations

Neural networks are used in many real-world applications, ranging from classification tasks to medical diagnostics. For each task, a neural network is typically able to make predictions due to its ability to extract meaningful patterns from processing large amounts of data. Thus, given the increases in available data in recent decades, the performance of neural networks in making accurate predictions has greatly increased. However, this data often comes with ingrained uncertainties due to measurement errors or the inherent variability of individual data points. Neural networks can learn despite the errors in the overall data, but what if we want them …

States Of Matter, Todd Sformo

Journal of Humanistic Mathematics

This is a non-fiction essay overtly about three methods used in overwintering physiology, set in the context of my first learning them, along with associated thoughts and ideas as I began working on my PhD. The mathematics shows up mainly in the final section of the essay whose subtitle plays on a poem by Wallace Stevens called “Anecdote of the Jar”. This section is fable-like in its explanation of protein purification and begins with an impossible statement that is slowly adjusted to make sense by words and math.

Bootstraps And Scaffolds: What A Cognitive-Historical Analysis Of The Complex Number System Reveals About Numerical Cognition, Charles R. Card, Gary G. Miller

Journal of Humanistic Mathematics

The following investigation is a cognitive-historical analysis of the conceptual development of complex numbers. The history of this development spans nearly two millennia, from the earliest appearance of the square root of a negative quantity in the calculations of Heron of Alexandra (1st Century CE) to the full flowering of complex numbers in the first half of the 19th Century. The approach used for this analysis is Nersessian's, including her formulations of model-based reasoning and mental models. Additional aspects of the analysis feature the prominent roles played by process representations, including object-process complementarities, and by core numerical systems. Our analysis …

Adult Coping As A Function Of Perceived Parental Support, Brenda Manning

Journal of Counseling and Psychology

The present study examined the function of perceived parental support in childhood on adult coping strategies. A convenient sample taken from social media collected data from fifty-three participants aged 20-68 who completed the Parental Acceptance-Rejection Questionnaires (PARQ) and Screening Tool for Adult Children of Alcoholic Traits (STACAT). Participants indicated moderate levels of parental (maternal and paternal) rejection (M=130.61, SD=37.67). Additionally, participants reported moderate levels of adult children of alcoholic traits related to perceived parental rejection (M=99.86, SD=22.82). Results indicated a statistically significant positive relationship (r = .534; p =.001) between perceived parental acceptance-rejection and adult children of alcoholic traits, suggesting …

The Effect Of Blood Flow Restriction Training On Quadriceps Activity After Anterior Cruciate Ligament Reconstruction: A Preliminary Randomized Controlled Trial, Florian Forelli, Camille Nguyen, Jean Mazeas, Georgios Kakavas, Timothy E. Hewett, Andreas Bjerregaard, Vasileios Korakakis, Alexandre Jm Rambaud

Marshall Journal of Medicine

Background

After anterior cruciate ligament reconstruction, a crucial priority is restoring knee muscle strength, especially the quadriceps, to reach the pre-injury strength levels as fast as possible. A feasible alternative to heavy loading might be blood flow restriction training that may elicit quadriceps muscle strength adaptations using low external loads. This study assessed whether quadriceps strengthening using low load blood flow restriction (LL-BFR) would enhance electromyographic (EMG) activity of the vastus medialis (VMO), vastus lateralis (VLO), and rectus femoris (RF) similar to quadriceps strengthening using heavy loads resistance training (HLRT). The secondary objective was to assess intra-quadriceps regional EMG differences …

Hands-On For Whom?, Isabella Stuopis, Avneet Hira

Journal of Pre-College Engineering Education Research (J-PEER)

Hands-on technology-enhanced pedagogies have been hailed as a panacea for engaging K–12 students in engineering. We unpack how the entanglement of the sociopolitical with the educational, namely how factors pertaining to resources and individual characteristics, impact engagement with such pedagogies. In particular, we expand upon how school funding, teacher preparation and support, access to out-of- school resources, and family background impact the in-and out-of- school resources students have access to. Further, we explain how characteristics such as a sense of belonging, pedagogical approaches, and assumptions and gatekeeping by adults impact students’ ability to engage with hands-on engineering education. In doing …

Parental Attitudes Toward Infant Sleep In The First Year Of Life: A Systems Framework, Shayna Sarah Zargari

ETD Collection

Previous research indicates that infant sleep is a complex topic for parents to navigate. Parents often face exhaustion and stress in putting their infants to sleep and may try different methods of encouraging them to sleep independently. Utilizing Uri Bronfebrenner’s Ecological Systems Theory (1979), this study examines parental background (e.g., occupation, race, religion, socioeconomic status) in relation to attitudes and interventions towards infant sleep. This research also considers where and how parents receive information regarding infant sleep and what supports parents rely on in navigating their infants’ sleep journeys. From a sample of mothers, this study finds that the macrosystem …

Riungan: Representation Of Muslim Betawi Pinggir Through The Practice Of Eating Together (A Case Study Of Kampung Pondok Pucung, Pondok Aren, South Tangerang), Gregorio Surya Abdi Julianto, Yudi Bachrioktora

International Review of Humanities Studies

Riungan is an eating-together event involving the kampung community as a form of religious worship and gratefulness/gratitude to God. Through an ethnography approach, with in-depth interviews and a literature review as a method, this research explores the relationship between the practice of eating together and cultural identity in riungan as held by the Muslim Betawi of Kampung Pondok Pucung. The result of this research shows that riungan has become a space to representation of the cultural identity of the Betawi Pinggir (peripheral Betawi), particularly emphasizing their cultural and Islam heritage. Through the types of food brought and the communal eating …

Hyperreality In Sharenting: Challenges Of Being An Indonesian Parent Today, Yosepha Arybowo, Maria Regina Widhiasti

International Review of Humanities Studies

The phenomenon of sharenting refers to the practice of parents, particularly mothers, sharing personal information in the form of text, photos, or videos about their child-rearing experiences and journey to parenthood on social media platforms. Social media, as a space of simulation, is considered to present an idealized version of parenting, showcasing perfect moments and achievements. This paper critically explores how the phenomenon of sharenting, especially by millennial mothers in Indonesia, contributes to the construction of family life representations that underlie parents' adaptation to idealized parenting standards on social media platforms. The paper samples sharenting content from several Instagram accounts …

Spatial Autocorrelation Of Tuberculosis Cases In Central Java Province In 2022, Izzatul Mardiah Saini, Tris Eryando

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Tuberculosis still becomes a health problem both in the world and in Indonesia. Central Java is The third highest province of tuberculosis in Indonesia. Spatial analysis is an essential tool for evaluating the tuberculosis distribution pattern according to geographic location. This research aims to determine tuberculosis hotspot areas and discover whether there is a spatial correlation between districts/cities in Central Java based on tuberculosis cases using the spatial autocorrelation method through the Moran Index and Local Indicators of Spatial Associations (LISA). Secondary data in the form of the aggregate number of all tuberculosis cases in 2022 was collected from the …

Innovative Education: Comparing The Success Of Stem And Traditional School Models, Timothy W. Kennedy

Education Theses and Dissertations

Abstract

This research study investigates the impacts of four specialized STEM education models—T-STEM (Texas Science, Technology, Engineering, and Mathematics), P-TECH (Pathways in Technology), Early College High Schools (ECHS), and New Tech Network schools (NTN) on student performance in Texas high schools. By analyzing aggregate student data collected by the state, this study compares the academic outcomes of students in these STEM-focused schools with those in traditional curriculum schools using ANCOVA (Analysis of Covariance) and Logistic Regression. The findings reveal mixed results: while some specialized STEM models show enhanced performance in STEM and other academic subjects, others do not consistently outperform …

Stricken By The Worst Type Of Sickness: The Communal Reaction And Response To Impaired Individuals In The Middle Ages, Alice Holland

Dissertations and Theses

Medieval communities often approached trouble within the fold collectively. This includes concerns over the health and safety of their individual members. This thesis examines the communal perception and treatment of disabled individuals in the Middle Ages. Using four twelfth-century miracle collections, The Miracles of Saint Gibrian (1145), The Life and Miracles of William of Norwich (1150-1172), The Miracles of Our Lady of Rocamadour (1172-1173), and The Miracles of Thomas Becket (1173-1179), I examine how communities created systems of care for their impaired members. In using these sources, which tell the stories of common individuals traveling to shrines for a saint's …

Itagaki Paru's Animalized Japan, Adoria Shanelle Walker

Dissertations and Theses

In the earlier works of manga artist and author Itagaki Paru, animal characters are used to prompt a discussion of the uchi/soto ("in-group"/"out-group") dynamic present in Japanese society. Throughout her most popular work, Beastars, and its supplemental short story collection Beast Complex, Itagaki tackles binary thinking and in-group versus out-group social politics using a blatantly obvious, yet nuanced and subtle herbivore-versus-carnivore, predator-versus-prey metaphor. The world she depicts in these works is full of misunderstandings caused by hastily made assumptions, sometimes instinctually quick. With her animalized characters, she explores human stigmatization and the poor treatment of those who do not want …

Keterkaitan Spasial Produksi Ikan Tawar Dan Dampak Sosial-Ekonomi Masyarakat Di Kabupaten Magelang, Didi Nuryadin, Rodhiah Umaroh, Jamzani Sodik

Jurnal Ekonomi dan Pembangunan Indonesia

This research analyzes the spatial correlation between freshwater aquaculture production in Magelang Regency and the social and economic welfare of the community. Utilizing the Indeks Moran, LISA, and bivariate LISA methods, the results indicate inter-district correlations in freshwater fish production with a clustered distribution pattern. Mungkid and Muntilan districts are identified as production centers and hotspots. Freshwater fish production is also associated with community welfare, showing correlations with farmer groups despite a scattered distribution. However, the analysis of freshwater fish production and freshwater fish-based SMEs reveals a strong spatial relationship, particularly in Mungkid district, a central area fostering local development.

Examining The Relationship Between Shift Work And Diabetes Mellitus Among Nurses: An Evidence-Based Case Report, Angga Arifianto, Indah Suci Widyahening, Levina Chandra Khoe, M. Ikhsan Mokoagow

Occupational and Environmental Medicine Journal of Indonesia

Background : Work shifts could cause numerous health problems, such as sleep disorders, weight gain disorders, and unhealthy food intake consumption, leading to obesity and changes in blood glucose levels, that eventually lead to diabetes mellitus. This evidence-based case report aims to provide an evidence of association between shift work and the risk of diabetes mellitus among nurses.

Methods : We performed a literature searching from Pubmed, Embase, Cochrane, Scopus, and Google Scholar in September 2023 using keywords ‘shift work’ AND ‘diabetes’ AND ‘nurse’. We included studies that assessed the association between shift work and diabetes among nurses using observational …

N-Acetyl-S-(N-Methylcarbamoyl)-Cysteine (Amcc) As Cumulative Biomonitoring Of Dimethylformamide Exposure Among Industrial Workers, Angga Arifianto, Muhammad Ilyas, Herqutanto .

Occupational and Environmental Medicine Journal of Indonesia

Background: N,N-Dimethylformamide (DMF) is an aliphatic amide which is miscible with water and a majority of organic liquids. Due to its amphiphilic properties, it is a widely used industrial solvent, especially for polymers. DMF has been consistently hepatotoxic, inducing effects on the liver at lowest concentrations or doses. N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC) which is one major metabolites of DMF, found in urine after DMF exposure of the whole workweek.

Objective: To determine the way of AMCC can be use as biomarker of DMF exposure and the best possible sampling time.

Method: This study conducted a literature search using evidence-based databases …