Digital Commons Network^™

The Benefits Of Biofouling – Promoting The Growth Of Benthic Organisms To Enhance Ecosystem Services, Kailey Nicole Richard, Kelli Z. Hunsucker, Travis J. Hunsucker, Geoffrey Swain

Ocean Engineering and Marine Sciences Student Publications

For the marine industry biofouling has a negative reputation. On ship hulls, the accumulation of these unwanted plants and animals can lead to increased drag, fuel consumption, and greenhouse gas emissions. Offshore platforms are also subject to biofouling which can result in corrosion and hydrodynamic loading, thus shortening their lifespan. While the harmful impacts of biofouling are commonly reported throughout the literature, biofouling can also benefit both aquatic and human populations. Common biofouling organisms act as natural filtration systems, thus improving water quality. Many of the same flora and fauna serve as a food source, and structures could be designed …

Emotionality Stigma Scale: Measurement Development, Reliability, And Validity., Hayley D. Seely

Electronic Theses and Dissertations

Emotions are biological responses to stimuli that allow individuals to derive meaning, appraise experiences, and prepare to respond. However, individuals perceive emotions differently based on emotion socialization which not only dictates the way emotions are viewed and managed but also has been directly linked with mental health outcomes. Furthermore, research shows emotion socialization is informed by demographic variables such as gender such that the expectations of emotionality differ; where women are taught to express emotions, men are taught to conceal. Given the societal rules regarding emotionality, it is possible that emotionality stigma – the stigma around the experience and expression …

From Surface To Subtext: Portrayals Of Success In Superfund Remediation., Haley Metcalf-Wade

Electronic Theses and Dissertations

Superfund sites represent some of the most contaminated and environmentally sensitive areas in the United States. How these sites are portrayed can significantly influence public perception of environmental risks, the effectiveness of remediation efforts, and the overall state of environmental health. Regulatory agencies like the Environmental Protection Agency (EPA) are entrusted with safeguarding public health and the environment. How they communicate about their actions, successes, and challenges directly impacts public trust and perceptions of their accountability. This dissertation examines the manifest and latent metrics used by the Environmental Protection Agency (EPA) to determine success in Superfund remediation by focusing on …

The Role Of Forest Disturbance And Habitat Characteristics In Shaping Arthropod Ecology., Kane Alec Lawhorn

Electronic Theses and Dissertations

Disturbances in forests often generate dead wood, which is an important resource for a variety of arthropods. In tropical wet forests where fire is rare, lightning and branchfalls are common disturbances that create canopy gaps with associated large amounts of localized dead wood. By contrast, prescribed fire is a common disturbance in temperate forest that creates habitat heterogeneity and widely dispersed dead wood resources. The ecological effects of these disturbances on arthropod communities are largely unknown. This dissertation investigates how disturbance and habitat associations in both tropical and temperate forest shape arthropod ecology. Throughout, I primarily focus on beetles, ants, …

Relation Between The Negative Cognitive Triad, Perceived Everyday Discrimination, Depressive Symptoms, And Tnf-A In Adolescents., Ashley Ann Marshall Dondanville

Electronic Theses and Dissertations

This study is based on Beck's cognitive stress-vulnerability model of depression and previous research on (a) the increased risk for severe illnesses associated with TNF-⍺ (i.e., an inflammatory cytokine), (b) the effect of perceived everyday discrimination (PED) on depressive symptoms and TNF-⍺, (c) the association between depressive symptoms and TNF-⍺, (d) and findings that the negative cognitive triad (i.e., negative views of the self, world, and future) serves as a partial mediator between PED and depressive symptoms. The purpose of this study is to integrate Beck’s model and these different research lines by inspecting the associations between the stressor PED …

Bayesian Approaches In Multi-State Markov Models And High Dimensional Time-To-Event Data., Yuchen Han

Electronic Theses and Dissertations

This dissertation consists of two projects. The first one involves nonparametric methods on Continuous Time Markov Chains (CTMCs). The second one is centered around Bayesian shrinkage models for detecting prognostic and predictive biomarkers in high-dimensional clinical data. Both these projects build on methods from across the frequentist and Bayesian paradigm to offer novel solutions. In the first project, we aim to model the nonlinear effects of continuous variables within multistate framework in a non-parametrically by appealing to the rich mathematical framework of Reproducing Kernel Hilbert Spaces (RKHS). Then we adapted the classical Representer Theorem to penalized (squared norm) log-likelihood which …

Functional Contribution Of Epithelial To Mesenchymal Transition Program On Krasg12d Targeting Efficacy In Pancreatic Cancer, Ana S. Maldonado

Dissertations and Theses (Open Access)

Functional contribution of epithelial to mesenchymal transition program on KRAS^G12D targeting efficacy in pancreatic cancer

Ana S. Maldonado, BS

Advisory Professor: Raghu Kalluri, M.D., Ph.D.

Pancreatic Ductal Adenocarcinoma (PDAC), a highly aggressive, metastatic, and therapeutically resistant form of pancreatic cancer has been projected to become the second-leading cause of cancer related mortality in the United States. This is driven by its detection difficulty, treatment efficacy, and asymptomatic nature, among other factors. PDAC is driven predominantly by KRAS^G12D mutations, which are responsible for the initial development of pancreatic intraepithelial neoplasia (Pan-IN) lesions, that are further maintained and progressed until …

The Role Of The Circadian Clock In The Paraventricular Nucleus Of The Hypothalamus In Diurnal Energy Balance, Rachel Van Drunen

Dissertations and Theses (Open Access)

Circadian rhythms are internal biological rhythms that drive oscillations in physiology and metabolism. Maintained at the level of individual cells throughout the body, the circadian clock is necessary for driving tissue-specific temporal programs of energy balance. Though loss of the circadian transcription factor, BMAL1, in the paraventricular nucleus (PVN) of the hypothalamus has revealed its importance in driving rhythms in energy intake and metabolism, its transcriptional functions across time and in individual cell types in the PVN are not well understood. In this study, we show that loss of BMAL1 in the PVN not only results in arrhythmicity in processes …

Exploring Chronic Stress, Avoidance Coping, And Diurnal Cortisol In Head And Neck Cancer Patients: A Pilot Study Of Best Practices In Diurnal Cortisol Sampling., Brooks R. Harbison

Electronic Theses and Dissertations

Cancer patients are vulnerable to the deleterious effects of chronic stress, especially those prone to avoidance coping. Research in the general population has linked these effects to aberrant diurnal cortisol. However, the current literature on cancer patients has shown inconsistent results in associations between chronic stress, avoidance coping, and diurnal cortisol, possibly due to inconsistent cortisol sampling practices. This pilot study of head and neck cancer patients aimed to address this gap in the literature by implementing best cortisol sampling practices to investigate the links among chronic stress, avoidance coping, and diurnal cortisol slope, average bedtime cortisol, and average wake …

The Influence Of Oxidative Stress On Ion Homeostasis And Glycolysis Activation, With Implications For Neurological Health And Multiple Sclerosis, Xavier Hayes

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Multiple sclerosis (MS) is a neurodegenerative disease in which the body’s immune system attacks its own tissues, notably the neural cells, and one of the contributing factors to this is oxidative stress. Oxidative stress is the build-up of reactive oxygen species ROS that causes oxidative damage to the cells. Chronic and environmental stressors are explored as significant factors that exacerbate these conditions by disrupting cellular processes and energy metabolism. The paper reviews current literature on MS, examining the interplay between oxidative stress, environmental factors, and genetic predispositions. Additionally, it discusses how these factors contribute to MS, where the immune system …

Antibacterial Efficacy Of 940 Nm Diode Laser Against Cariogenic Bacteria (Tooth Decay-Causing Bacteria), Noha M. Jameel, Hanan J. Taher

Baghdad Science Journal

Dental caries is an extremely prevalent infectious disease caused by gram-positive bacteria mainly streptococcus mutans which is considered the major etiological factor causing dental caries. In recent years, there has been an enormous increase in the use of laser technology in medicine and dentistry and it has been demonstrated to have a considerable antibacterial action with no harm to the oral tissues. The study goal was to assess a diode laser's effectiveness as an antibacterial agent against the bacterium species S. mutans at various doses. The study was performed on streptococcus mutans microorganism at 106 CFU/ml concentration which received irradiation …

Examining Mental Health Professionals' Attitudes Towards Individuals With Rural Accents, Emily Heavner

Theses and Dissertations

Bias against people from rural areas is ingrained in American culture, and stereotypes that people from rural regions are backwards, uneducated, and unintelligent are prevalent (Fulkerson & Thomas, 2016; Hartman et al., 2023; Howley, 2009; Shirley, 2010). Many people from rural areas have accents that mark them as coming from a rural region (Flanigan, 2000). Research suggests that accent is a reminder that the speaker is from a different cultural group than the listener, triggering biases and stereotypes about the speaker (Chakraborty, 2017). Because accent and rural culture are not often discussed as part of multicultural competence, many mental health …

Echo: A Graphical User Interface Designed To Simulate, Study, And Mitigate Effects Of Interplanetary Communication Delays In Analog Missions, Dario Gabriel Schor

Theses and Dissertations

Due to the vast distances between Earth and other planets, future human interplanetary missions will experience significant communication delays. The literature suggests that a combination of training, protocols, procedures, and tools is required to mitigate the negative impact that the communication delay has on both stress and performance. This research introduces a tool called ECHO that combines known and novel features designed to make users cognizant of the delay and avoid misunderstandings. ECHO was tested as part of a mixed-methods study over the course of three analog missions at the University of North Dakota's Integrated Lunar/Mars Habitat where a total …

Sustainable Synthesis: An Emphasis On Green Chemical Reactions Using Eco-Uva Light For [2+2] Photocycloadditions Of Furan Derivatives, Sierra Rose Ward

Theses and Dissertations

The first section of this study investigates the effect of low temperatures on [2+2] photocycloaddition reactions of a furan derivative, furyl acrylic acid, which can be derived from biomass, and its effect on various photoactive monomers. The experiments demonstrated that the furan derivative could dimerize in extreme temperatures (-196 oC) using liquid nitrogen with up to 82% conversion. The second chapter is dedicated to developing a more environmentally friendly reaction procedure for a different furan derivative, maleic anhydride, with simple olefins (specifically cyclohexene and 1-hexene). Traditionally, these reactions were performed with medium-pressure mercury lamps, conventional photochemical reaction vessels, and flow …

Transcriptional Landscape Of Foxp3+ Regulatory T Cells Under Mitochondrial Oxidative Stress: Implications For Inflammaging, Jappreet Singh Gill

Theses and Dissertations

This thesis explores the intricate relationship between mitochondrial oxidative stress and the function of FOXP3+ regulatory T cells (Tregs), highlighting their essential roles in the aging immune system and the development of age-related diseases. The study delves into how mitochondrial impairments within Tregs contribute to widespread inflammation leading to pathological aging. One key analysis shows that mitochondrial oxidative stress undermines Treg functionality, intensifying inflammatory responses and increasing frailty in older adults. This dysfunction is associated with elevated inflammatory markers and presents a potential target for therapeutic interventions aimed at restoring mitochondrial health to alleviate these impacts. Another significant discovery connects …

The Association Between Social Media, Toxic Masculinity, And Depression In Young Adult Males, Anthony Warren

Dissertations

The world is shaped by diverse influences that significantly affect individuals’ internal landscapes, leading to both positive and negative effects with profound implications for society. Role models play a pivotal role in shaping the aspirations of young adult males by providing direct and indirect lessons that leave lasting impressions and influence their worldview. In recent years, social media use, toxic masculinity, and mental health have garnered significant attention in understanding the experiences of young adult males. The focus in this study was to examine the relationships between social media use, toxic masculinity, and depression in young adult males ranging in …

Robust Hydropower Planning Balances Energy Generation, Carbon Emissions And Sediment Connectivity In The Mekong River Basin, M. Tangi, Rafael Schmitt, Rafael M. Almeida, S. Bossi, Alexander S. Flecker, F. Sala, A. Castelletti

School of Earth, Environmental, & Marine Sciences Faculty Publications

We present a framework for strategic dam planning under uncertainty, which includes GHG emissions mitigation as a novel objective. We focus on the Mekong River Basin, a fast‐developing region heavily relying on river‐derived ecosystem services. We employ a multi‐objective evolutionary algorithm to identify strategic dam portfolios for different hydropower expansion targets, using process‐related and statistical models to derive indicators of sediment supply disruption and GHG emissions. We introduce a robust optimization approach that explores variations in optimal portfolio compositions for more than 5,000 state‐of‐ the‐world configurations, regarding sediment origins and trapping and GHG emissions. Thus, we can rank dam projects' …

Hydroxyapatite Of Cow Bone Used As Filler To Enhance Compressive Strength Characteristics In Composite Restoration, Syamsiah Syam, Nur F. Arifin, Risnayanti Anas

Journal of Dentomaxillofacial Science

Objective: The goal of the current study is to ascertain whether hydroxyapatite from cow bones could potentially be used as a filler to improve the compressive strength characteristics of composite fillings. Material and Methods: The composite filling material used in the test group was self-processed and comprised filler derived from hydroxyapatite of cow bones, which were synthesized via an alkaline hydrothermal method.  A composite material manufactured at a factory with silica filler served as the control group. Each group was formed into 16 slabs, each measuring 2 mm thick and 6 mm in diameter. The slabs were polymerized using light …

Math Meets The Clinic: Modeling Patient Specific Hnscc Radiation Response Dynamics, Rohan Vijayvikram, Pirmin Schlicke, Mohammad U. Zahid, Dina M. El-Habashy, Cem Dede, Clifton D. Fuller, Heiko Enderling

Radiation Oncology Medical Student Program 2024

Head and neck squamous cell carcinomas (HNSCCs) originate from the mucosal lining of the upper aerodigestive tract and radiation therapy has become a fundamental component in the standard care for these patients. However, the treatment's unique dynamics can lead to disparities in outcomes and biological responses in both tumor and normal tissues. A significant challenge remains in predicting individual patient responses to radiation, with variability often resulting in under or over-treatment and potentially adverse effects. The absence of reliable biomarkers highlights the need for predictive measures to guide clinical decisions in real-time. The integration of mathematical models in radiation therapy …

Adaptation To The Impacts Of Climate Change On Water Availability In The Upper Red River Of The North (Urrn), Innocent Kelechi Anosike

Theses and Dissertations

In the Upper Red River of the North (URRN), climate change has appeared to impact water availability, causing several major floods in recent years, and raising questions about whether climate change is responsible for the frequent occurrence of flooding in this major agricultural region in the Midwest USA. This thesis centers on investigating adaptative measures to mitigate the impacts of climate change in the URRN. One of the methods used is to compare changes in the outcomes of flood frequency analysis (FFA) for “before (pre-industrial) and after (industrial)” time periods. The study uses a combination of data analysis and literature …

Evaluation And Mitigation Of Wildlife-Vehicle Collisions In North Dakota, Amalie Victoria Joergensen

Theses and Dissertations

Annually, 365 million vertebrates are estimated killed in wildlife-vehicle collisions (WVC) in the US. Not only is this a threat to wildlife species, but it causes more than 25,000 human injuries, 200 human deaths, and over $10 billion in damage costs. North Dakota has a high rate of WVCs where more than 18 % of all collisions involve wildlife. Based on North Dakota Department of Transportation (NDDOT) crash data, we identify factors that affect the number of WVCs in North Dakota, and how these differ between different crash reporting methods. Additionally, we locate the WVC hotspots in North Dakota and …

Maturational Changes In The Epigenome And Transcriptome Of Hypothalamic Astrocytes: Implications For Axonal Regeneration, Abiodun Ebenezer Odufuwa

Theses and Dissertations

Axon regeneration is essential for effective repair following injury in the CNS. One of the burdens of aging is the lack of recovery following injury in the CNS. Our previous studies show that in 35-day-old rats, axon regeneration occurs in response to a unilateral hypothalamic lesion in the hypothalamus neurohypophyseal system. However, this regenerative ability is lost in 125-day-old rats. Furthermore, treatment of hypothalamic organotypic culture with ciliary neurotrophic factor (CNTF) promotes axonal outgrowth and survival. Our previous studies suggest that astrocytes may be playing critical roles in this maturational loss of regenerative capacity because only astrocytes expressed all the …

Opencast: Cyanobacteria Growth And Correlations With Predictive Factors In Creation For Harmful Algal Bloom Formation, Devarshi Nikhil Patel

Theses and Dissertations

Harmful Algal Blooms (HABs) are a significant threat to aquatic ecosystems, public health, and local economies due to their production of toxins and negative impacts on water quality. This thesis investigates the correlations between cyanobacteria growth and environmental variables, including wind conditions, surface temperatures, and nutrient levels. This research uses machine learning and statistical modeling to predict HAB occurrences by analyzing these variables' historical and near real-time data. The findings indicate that wind speed, surface temperature, and nutrient levels influence cyanobacteria dynamics, with specific thresholds identified for predictive accuracy. The developed HAB predictive models and the graphical user interface (GUI) …

Pl 93-638: Utilizing The Indian Self Determination And Education Assistance Act (Isdeaa) To Enhance And Improve Oral Health Outcomes In A Tribal Community, Adriann Darlene Ricker

Theses and Dissertations

American Indians and Alaskan Natives experience the worst oral health outcomes. However, we are transitioning to a new era where Indigenous communities are reclaiming the narrative and health. This dissertation in practice was inspired by tribal self-determination and reclamation of health found through the newly established Fort Peck Tribal Health Dental Department utilizing the Indian Self Determination and Education Assistance Act (PL 93-638). The guiding framework for the Fort Peck Tribal Health Dental Department and this dissertation is the Indigenous Primary Health Care Delivery Model which illuminates elements of community, empowerment, and self-determination with culture as center to all healthcare …

Engineered Nucleic-Acid Binding Intrinsically Disordered Proteins For Biomedical Applications, Telmo Diez Perez

Biomedical Engineering ETDs

This dissertation explores the use of intrinsically disorder proteins (IDPs) in biomedical applications related to the detection and biosensing of nucleic-acid species. We engineer several low critical solution temperature (LCST) nucleic-acid binding elastin-like polypeptides (ELPs) as model IDPs and study their potential in biomedical application via interactions with short single-stranded (ss) DNA, tRNA and viral RNAs. First, we engineer a simple polycationic ELP capable of recruiting DNA on demand in a DNA-protein-rich condensate via LLPS. Moreover, we develop a modified Flory-Huggins theory to quantify the partitioning of DNA and protein upon coacervate formation with and without salts. We then design …

Faculty Perceptions About Instructional Accommodations For Students With Social Anxiety Disorder, Jessie Frances Edith Tudor-Tangeman

Walden Dissertations and Doctoral Studies

The problem examined was that post-secondary faculty experience challenges related to providing responsive accommodations to post-secondary students who self-identify with a diagnosis of social anxiety disorder (SAD). The purpose of this study was to investigate post-secondary faculty’s perceptions of their ability to make responsive instructional modifications beyond the preliminary accommodations mandated by university disability services for post-secondary students who self-identify as experiencing SAD. The conceptual framework that grounds this study was Clark and Wells’ (1995) cognitive model of social phobia. The research questions focused on the perceptions of post-secondary faculty in relation to their ability to make responsive instructional modifications …

Preschool Executive Control And Adolescent Dietary Outcomes: Highlighting The Role Of Context, Marla Lopez

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Research has identified executive control (EC) as an important predictor of dietary outcomes among youth. Executive control in preschool age has been shown to predict important outcomes across development for youth, indicating that good, foundational EC abilities are associated with successful development in later life. Dietary outcomes across adolescence, an important transitional period for establishing healthy eating behaviors, are understudied. Therefore, the current study sought to link two critical developmental periods, examining how preschool EC is associated with dietary trajectories across adolescence. Further, the study aimed to identify how contextual factors, specifically indices of socio-economic status and the home and …

Applications Of Artificial Intelligence On Drought Impact Monitoring And Assessment, Beichen Zhang

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Drought, a prevalent and consequential natural disaster, poses widespread, indirect challenges across environmental and societal dimensions. Despite considerable focus on monitoring meteorological and hydrological drought and studying their characteristics, there is a gap in assessing its multifaceted impacts, especially on societal sectors. The dissertation comprises three research essays utilizing artificial intelligence to quantitatively study multi-dimensional drought impacts. The first essay leveraged deep learning and natural language processing to predict multi-dimensional drought impacts from textual datasets, including social media, news media, and citizen scientist reports. The findings demonstrate superior performance over traditional methods and unveil the spatial and temporal heterogeneity of …

Investigating Associations Between Activity And Performance Traits Across Three Breeds Of Swine Using NuTrack, Dalton R. Obermier

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Feed costs are the largest contributor towards the variable costs of pork production. To decrease feed cost while not sacrificing output requires an improvement in feed efficiency (FE). A potential approach to expand available phenotypes associated with FE is with activity tracking, yet the relationship between activity and performance is not well defined in swine. Therefore, the objective of this study was to quantify associations between activity and feed intake traits. Average daily feed intake (ADFI) was collected on 1,766 purebred boars of three genetic lines (Duroc, Landrace, and Yorkshire) using FIRE (Osborne Industries, Inc., Osborne, Kansas) at a testing …

Optimizing Scalability For Formal Analysis With Evolutionary Algorithm, Jianghao Wang

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Predominantly employed to tackle hardware validation challenges in the early years, formal methods have since expanded to software engineering, introducing a significant level of rigor and precision to software analysis. Its use of mathematical notations and logical reasoning allows for abstract modeling of programs, enabling researchers and engineers to perform a multitude of analysis tasks to verify system dependability and rigorously prove the correctness of system properties. Despite the availability of many automated analysis tools including those considered lightweight, the practical adoption of formal methods in software development has been limited due to scalability concerns, especially when applied to large …