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Qtl Mapping For Fatty Acid Composition In Olive Oil Using A High-Density Genetic Map Based On Snp Markers, Ali̇ Can Kaya, Meryem İpek, Ahmet İpek, Mehmet Ali̇ Gündoğdu, Nesri̇n Aktepe Tangu, Sevi̇n Teoman Duran, Murat Şeker, Mustafa Akbulut Aug 2024

Qtl Mapping For Fatty Acid Composition In Olive Oil Using A High-Density Genetic Map Based On Snp Markers, Ali̇ Can Kaya, Meryem İpek, Ahmet İpek, Mehmet Ali̇ Gündoğdu, Nesri̇n Aktepe Tangu, Sevi̇n Teoman Duran, Murat Şeker, Mustafa Akbulut

Turkish Journal of Agriculture and Forestry

Olive (Olea europaea L.) is an evergreen tree species that grows naturally in regions with Mediterranean climates. Its oil and fruits are commercially valuable. Olive oil contains high levels of omega-9 (oleic acid). Because the high percentage of oleic acid makes olive oil deterioration-resistant, the development of olive varieties containing high oleic acid is one of the major goals of olive breeding programs. Therefore, this study aimed to determine quantitative trait loci (QTL) affecting fatty acid composition of olive oil. Thus, early selection of olive genotypes with a high oleic acid content can be possible. For the determination of QTLs …


Legal Regime Of The Application Process For Gmo Products In Türkiye, Ünal Yildiz, Özgür Temi̇z, Kami̇l Hali̇loğlu, Nesri̇n Yildiz Aug 2024

Legal Regime Of The Application Process For Gmo Products In Türkiye, Ünal Yildiz, Özgür Temi̇z, Kami̇l Hali̇loğlu, Nesri̇n Yildiz

Turkish Journal of Agriculture and Forestry

In Turkiye, in accordance with EU harmonization laws, Biosafety Act No. 5977 entered into force on 18.09.2010. The basic legislation regarding the application process is composed of the Biosafety Act, Regulations on Genetically Modified Organisms and Their Products, and Regulations on Working Procedures and Principles of Biosafety Board and Committees. Biosafety legislation foresees a special application procedure for GMO food, food products, feed, and other products. The application regulated in the Biosafety Law is a special administrative procedure in nature. The primary objective of this study is to explain the legal regime of this application procedure. While explaining this issue, …


Quantitative Variation Of Phenolic Compounds In Different Tissues Of Pistachio(Pistacia Vera L. Cv. Uzun) Associated With Alternate Bearing, Müjgan Güney, Muhammet Ali̇ Gündeşli̇, Murat Güney, Nesi̇be Ebru Kafkas, Sali̇h Kafkas, Zeynep Ergün Aug 2024

Quantitative Variation Of Phenolic Compounds In Different Tissues Of Pistachio(Pistacia Vera L. Cv. Uzun) Associated With Alternate Bearing, Müjgan Güney, Muhammet Ali̇ Gündeşli̇, Murat Güney, Nesi̇be Ebru Kafkas, Sali̇h Kafkas, Zeynep Ergün

Turkish Journal of Agriculture and Forestry

Alternate bearing is a common challenge in horticultural plants, leading to irregular yield in successive years. The potentialrole of phenolic compounds in regulating this phenomenon, however, is not well understood. This study aimed to investigate thepotential role of phenolic compounds in alternate bearing in pistachio trees by analysing samples from different parts of the “Uzun”cultivar over two consecutive years. Seven phenolic compounds (gallic acid, p-coumaric acid, caffeic acid, ferulic acid, chlorogenic acid,catechin, and quercetin) were analysed using high-performance liquid chromatography at 10-day intervals. Significant variations wereobserved in the levels of certain phenolic compounds between “ON” and “OFF” years, suggesting a …


Developing Micropropagation Protocol For Black Mulberry (Morus Nigra L.), Merve Özkul, Nevzat Sevgi̇n, Mehmet Özkul, Neelam Prabha Negi, Sadi̇ye Peral Eyduran, Bi̇rsen Yilmaz, Melekşen Akin Aug 2024

Developing Micropropagation Protocol For Black Mulberry (Morus Nigra L.), Merve Özkul, Nevzat Sevgi̇n, Mehmet Özkul, Neelam Prabha Negi, Sadi̇ye Peral Eyduran, Bi̇rsen Yilmaz, Melekşen Akin

Turkish Journal of Agriculture and Forestry

This study aims to develop a suitable micropropagation protocol for black mulberry, which cannot be easily clonally propagated like other mulberry species. Clonal propagation of this species is gaining importance due to its health benefits and utilization in pharmacology. The effects of culture media and cytokinin types on micropropagation of Morus nigra L. were investigated. Single-axillary bud explants grown on MS, DKW, and NRM containing 0.25 mg/l benzyl adenine (BA) plus 0.01 mg/l indole-3-butyric acid (IBA) were compared to cultures grown on NRM with thidiazuron, metaTopolin (mT) or BA at 1.25, 2.5, 5.0 or 7.5 mg/l plus 0.01 mg/l IBA. …


Biostimulation Effect On Crithmum Maritimum L. Root Development In Controlled Environment, Stefano Zenobi, Marco Fiorentini, Biagio Di Tella, Vesna Milanovic, Andera Marcelli, Luigi Ledda, Paola Antonia Deligios, Lucia Aquilanti, Roberto Orsini Aug 2024

Biostimulation Effect On Crithmum Maritimum L. Root Development In Controlled Environment, Stefano Zenobi, Marco Fiorentini, Biagio Di Tella, Vesna Milanovic, Andera Marcelli, Luigi Ledda, Paola Antonia Deligios, Lucia Aquilanti, Roberto Orsini

Turkish Journal of Agriculture and Forestry

Biostimulants can find application in sustainable agriculture contexts as they are regarded as inputs with minimal environmental impact. Microbial inoculants, when applied to the root systems of certain plant species, confer physiological and morphological benefits to the entire plant. In the present study, we focused on some morphometric parameters of the root system of two Crithmum maritimum L. spontaneous populations (Mediterranean and Atlantic). We compared the effects of two different (for number of strains) biostimulants on the weight, length, diameter and number of tips on the root system. The experiment was conducted within two types of controlled environments: i) an …


Characterization And Bioremediation Potential Of Heavy-Metal Resistant Bacteria Isolated From Agricultural Soil, Kheira Dahnoun, Fatima Djadouni, Badiaa Essghaier, Chahnez Naccache, Nadia Zitouna, Salwa Zehdi-Azouzi, İsmai̇l Bayyi̇ği̇t, Hijran Rafiyeva Latif, Maha Mezghani-Khemakhem, Hedia Bourguiba Aug 2024

Characterization And Bioremediation Potential Of Heavy-Metal Resistant Bacteria Isolated From Agricultural Soil, Kheira Dahnoun, Fatima Djadouni, Badiaa Essghaier, Chahnez Naccache, Nadia Zitouna, Salwa Zehdi-Azouzi, İsmai̇l Bayyi̇ği̇t, Hijran Rafiyeva Latif, Maha Mezghani-Khemakhem, Hedia Bourguiba

Turkish Journal of Agriculture and Forestry

Heavy metal pollution is a major environmental issue that has a negative impact on soil quality and food security. As a result, heavy metal removal or remediation from hazardous sites has become mandatory. Bioremediation based on microorganisms is a promising method to remediate heavy metal-contaminated areas due to its eco-friendly, cost-effective, and highly efficient characteristics. This study aimed to isolate, identify and characterize rhizospheric bacteria able to resist, reduce, and detoxify heavy metals (chromium [Cr], nickel [Ni], and aluminum [Al]) from agricultural soil. Two isolates were chosen due to their high level of heavy metal resistance and could serve as …


Evaluation Of Turkish Shallot Genetic Resources For Morphological, Biochemical And Sensory Properties, Gülay Beşi̇rli̇ Aug 2024

Evaluation Of Turkish Shallot Genetic Resources For Morphological, Biochemical And Sensory Properties, Gülay Beşi̇rli̇

Turkish Journal of Agriculture and Forestry

Shallots, a subspecies of onion, are considered the gourmet onion and are preferred especially in French and Asian cooking. Its unique taste and aroma especially being caramelized through heat treatment increases its importance for boutique restaurants and niche tables. This study examined the morphological, biochemical, and sensory properties of seven generatively (GMSY-2, GMSY-3, GMSY-4, GMSY-5, GMSY-6, GMSY-7, GMSY-8) and one vegetatively propagated (GMSY-1) shallot genotypes in 2021 and 2022. Sixteen morphological and fifteen biometric features of UPOV were used in characterization. Total phenolic content, total antioxidant capacity, and total monomeric anthocyanin and pyruvic acid contents were determined as biochemical markers. …


Proximity Analysis Of Native Proteomes Reveals Phenotypic Modifiers In A Mouse Model Of Autism And Related Neurodevelopmental Conditions, Yudong Gao, Daichi Shonai, Matthew Trn, Jieqing Zhao, Erik J Soderblom, S Alexandra Garcia-Moreno, Charles A Gersbach, William C Wetsel, Geraldine Dawson, Dmitry Velmeshev, Yong-Hui Jiang, Laura G Sloofman, Joseph D Buxbaum, Scott H Soderling Aug 2024

Proximity Analysis Of Native Proteomes Reveals Phenotypic Modifiers In A Mouse Model Of Autism And Related Neurodevelopmental Conditions, Yudong Gao, Daichi Shonai, Matthew Trn, Jieqing Zhao, Erik J Soderblom, S Alexandra Garcia-Moreno, Charles A Gersbach, William C Wetsel, Geraldine Dawson, Dmitry Velmeshev, Yong-Hui Jiang, Laura G Sloofman, Joseph D Buxbaum, Scott H Soderling

Faculty, Staff and Students Publications

One of the main drivers of autism spectrum disorder is risk alleles within hundreds of genes, which may interact within shared but unknown protein complexes. Here we develop a scalable genome-editing-mediated approach to target 14 high-confidence autism risk genes within the mouse brain for proximity-based endogenous proteomics, achieving the identification of high-specificity spatial proteomes. The resulting native proximity proteomes are enriched for human genes dysregulated in the brain of autistic individuals, and reveal proximity interactions between proteins from high-confidence risk genes with those of lower-confidence that may provide new avenues to prioritize genetic risk. Importantly, the datasets are enriched for …


Re: Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp) Bres No. 74 – West Gagnon Dump., Mike Mcanulty Aug 2024

Re: Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp) Bres No. 74 – West Gagnon Dump., Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Kat2a And Kat2b Prevent Double-Stranded Rna Accumulation And Interferon Signaling To Maintain Intestinal Stem Cell Renewal, Mai-Uyen Nguyen, Angela Halstead, José B Sáenz, Et Al. Aug 2024

Kat2a And Kat2b Prevent Double-Stranded Rna Accumulation And Interferon Signaling To Maintain Intestinal Stem Cell Renewal, Mai-Uyen Nguyen, Angela Halstead, José B Sáenz, Et Al.

2020-Current year OA Pubs

Histone acetyltransferases


Epigenetic Reprogramming Driving Successful And Failed Repair In Acute Kidney Injury, Yoshiharu Muto, Eryn E Dixon, Yasuhiro Yoshimura, Nicolas Ledru, Yuhei Kirita, Haojia Wu, Benjamin D Humphreys Aug 2024

Epigenetic Reprogramming Driving Successful And Failed Repair In Acute Kidney Injury, Yoshiharu Muto, Eryn E Dixon, Yasuhiro Yoshimura, Nicolas Ledru, Yuhei Kirita, Haojia Wu, Benjamin D Humphreys

2020-Current year OA Pubs

Acute kidney injury (AKI) causes epithelial damage followed by subsequent repair. While successful repair restores kidney function, this process is often incomplete and can lead to chronic kidney disease (CKD) in a process called failed repair. To better understand the epigenetic reprogramming driving this AKI-to-CKD transition, we generated a single-nucleus multiomic atlas for the full mouse AKI time course, consisting of ~280,000 single-nucleus transcriptomes and epigenomes. We reveal cell-specific dynamic alterations in gene regulatory landscapes reflecting, especially, activation of proinflammatory pathways. We further generated single-nucleus multiomic data from four human AKI samples including validation by genome-wide identification of nuclear factor …


Untargeted Lipidomics Reveals Racial Differences In Lipid Species Among Women, Ghazaleh Pourali, Liang Li, Kayla R Getz, Myung Sik Jeon, Jingqin Luo, Chongliang Luo, Adetunji T Toriola Aug 2024

Untargeted Lipidomics Reveals Racial Differences In Lipid Species Among Women, Ghazaleh Pourali, Liang Li, Kayla R Getz, Myung Sik Jeon, Jingqin Luo, Chongliang Luo, Adetunji T Toriola

2020-Current year OA Pubs

Understanding the biological mechanisms underlying racial differences in diseases is crucial to developing targeted prevention and treatment. There is, however, limited knowledge of the impact of race on lipids. To address this, we performed comprehensive lipidomics analyses to evaluate racial differences in lipid species among 506 non-Hispanic White (NHW) and 163 non-Hispanic Black (NHB) women. Plasma lipidomic profiling quantified 982 lipid species. We used multivariable linear regression models, adjusted for confounders, to identify racial differences in lipid species and corrected for multiple testing using a Bonferroni-adjusted p-value <  10


Aquaponics Experiment For Njit Stem For Success, Christopher Tava Aug 2024

Aquaponics Experiment For Njit Stem For Success, Christopher Tava

STEM Month

As a member of STEM for Success, I was responsible for constructing and promoting a functioning aquaponics system for the benefit of fifth grade students. With the help of NJIT funding, I was able to design, rapid prototype, and then implement a sustainable aquaponics system that was able to grow lettuce, tomatoes, and kale. Multiple challenges in the design process led to changes, further research, and the implementation of new solutions, as described in detail. Using the aquaponics knowledge gained from the experimental phase, I then led community outreach to elementary schools in my local area. Aquaponics possesses a variety …


Neuromorphic Star Tracking Using Monte Carlo Localization, Connor Gisburne, Alex Warren, Steven Allen, Michael Bantel, Justin James Aug 2024

Neuromorphic Star Tracking Using Monte Carlo Localization, Connor Gisburne, Alex Warren, Steven Allen, Michael Bantel, Justin James

Small Satellite Conference

Accurate attitude determination ensures precise payload sensor alignment and optimal solar panel positioning, enhancing data collection and power efficiency while ensuring stable orbit maintenance. The most accurate method of attitude determination is star tracking. Star trackers collect an image of a star field and utilize a catalog of known star positions to calculate the orientation of the system relative to the stars. The errors present in this method of attitude determination tend to be on the order of ten arcseconds or less. Using traditional collection techniques, attitude estimates can be provided at update rates of 1 to 10 Hz and …


The Bosuns Locker: A Universal Payload Enclosure For In Space Manufacturing & Robotic Assembly In Space, Noah Gladden, Rahul Rughani, Dave Barnhart Aug 2024

The Bosuns Locker: A Universal Payload Enclosure For In Space Manufacturing & Robotic Assembly In Space, Noah Gladden, Rahul Rughani, Dave Barnhart

Small Satellite Conference

Arkisys is dedicated to enabling payloads to reach LEO that don't have a free-flying requirement. Our unique Port Module is an autonomous long-duration modular orbital platform designed to host payloads and servicing technologies in any orbit with a simple process, with the first roll-out in LEO. It will enable our customers to qualify and test their hardware in orbit in less than 90 days!


Patient Experience And Virtual Reality: The Use Of An Mri Exam Simulator, Jaqueline Maria Da Silva Jms, Marcus Antonio Medeiros De Souza Mams, Mônica Augusta Reis Dos Santos Mars, Milena Loureiro De Melo Mlm, Lorena De Fátima Lucena Almeida Lfla, Alayde Ricardo Da Silva Ars, Êmilly Vitória Dos Santos Vieira Evsv, Alessandra Nascimento Pontes Anp, Jandson De Oliveira Soares Jos Aug 2024

Patient Experience And Virtual Reality: The Use Of An Mri Exam Simulator, Jaqueline Maria Da Silva Jms, Marcus Antonio Medeiros De Souza Mams, Mônica Augusta Reis Dos Santos Mars, Milena Loureiro De Melo Mlm, Lorena De Fátima Lucena Almeida Lfla, Alayde Ricardo Da Silva Ars, Êmilly Vitória Dos Santos Vieira Evsv, Alessandra Nascimento Pontes Anp, Jandson De Oliveira Soares Jos

Patient Experience Journal

Magnetic resonance (MR) imaging is a safe diagnostic method of high accuracy detection and characterization of various pathological conditions. However, due to the very closed aspect of the apparatus, the high sound amplitude emitted and the need to remain motionless for a significant time, some patients experience discomfort and high levels of anxiety, compromising time and image quality management that can impair the clinical outcome of the patient or even give up the performance of this procedure. Therefore, this study aimed to validate, with patients, the use of Virtual Reality (VR) as a humanized practice of exposure to magnetic resonance …


High Mobility Group Box 1 (Hmgb1) Is A Potential Disease Biomarker In Cell And Mouse Models Of Duchenne Muscular Dystrophy, Rebecca A. Slick, Jessica Sutton, Margaret Haberman, Benjamin S. O'Briens, Jennifer A. Tinklenberg, Aashay Mardikar, Mariah J. Prom, Margaret Beatka, Melanie Gartz, Mark A. Vanden Avond, Emily Siebers, David L. Mack, J. Patrick Gonzalez, Allison D. Ebert, Kanneboyina Nagaraju, Michael W. Lawlor Aug 2024

High Mobility Group Box 1 (Hmgb1) Is A Potential Disease Biomarker In Cell And Mouse Models Of Duchenne Muscular Dystrophy, Rebecca A. Slick, Jessica Sutton, Margaret Haberman, Benjamin S. O'Briens, Jennifer A. Tinklenberg, Aashay Mardikar, Mariah J. Prom, Margaret Beatka, Melanie Gartz, Mark A. Vanden Avond, Emily Siebers, David L. Mack, J. Patrick Gonzalez, Allison D. Ebert, Kanneboyina Nagaraju, Michael W. Lawlor

Pharmacy Faculty Scholarship

Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder affecting 1:3500 male births and is associated with myofiber degeneration, regeneration, and inflammation. Glucocorticoid treatments have been the standard of care due to immunomodulatory/immunosuppressive properties but novel genetic approaches, including exon skipping and gene replacement therapy, are currently being developed. The identification of additional biomarkers to assess DMDrelated inflammatory responses and the potential efficacy of these therapeutic approaches are thus of critical importance. The current study uses RNA sequencing of skeletal muscle from two mdx mouse models to identify high mobility group box 1 (HMGB1) as a candidate biomarker potentially …


Revolutionizing Wild Silk Fibers: Ultrasound Enhances Structure, Properties, And Regenerability Of Protein Biomaterials In Ionic Liquids., Xincheng Zhuang, Haomiao Zhu, Fang Wang, Xiao Hu Aug 2024

Revolutionizing Wild Silk Fibers: Ultrasound Enhances Structure, Properties, And Regenerability Of Protein Biomaterials In Ionic Liquids., Xincheng Zhuang, Haomiao Zhu, Fang Wang, Xiao Hu

College of Science & Mathematics Departmental Research

Ultrasound-assisted regulation of biomaterial properties has attracted increasing attention due to the unique reaction conditions induced by ultrasound cavitation. In this study, we explored the fabrication of wild tussah silk nanofiber membranes via ultrasound spray spinning from an ionic liquid system, characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), atomic force microscopy (AFM), water contact angle, cytocompatibility tests, and enzymatic degradation studies. We investigated the effects of ultrasound propagation in an ionic liquid on the morphology, structure, thermal and mechanical properties, surface hydrophilicity, biocompatibility, and biodegradability …


College Appoints New Endowed Chairs In The Natural And Social Sciences, Dave Larsen Aug 2024

College Appoints New Endowed Chairs In The Natural And Social Sciences, Dave Larsen

College of Arts and Sciences Newsroom

The University of Dayton College of Arts and Sciences appointed three endowed chairs, including a pair of husband-and-wife geneticists.


The Science And Philosophy Of The Brain And The Future Of Neuroscience, Julian Paul Keenan Aug 2024

The Science And Philosophy Of The Brain And The Future Of Neuroscience, Julian Paul Keenan

Department of Biology Faculty Scholarship and Creative Works

No abstract provided.


Impact Of Site Rehabilitation On Local Insect And Pollinator Populations: A Case Study Of Newly Restored Mining Lands In Butte, Montana, Nicholas Rasschaert Aug 2024

Impact Of Site Rehabilitation On Local Insect And Pollinator Populations: A Case Study Of Newly Restored Mining Lands In Butte, Montana, Nicholas Rasschaert

Graduate Theses & Non-Theses

Pollinators play a critical role in ecosystem functionality, with 80% of the world's plant species depending on animal-mediated pollination. Given that habitat loss is a primary threat to pollinators and many species are becoming threatened in the US, restoration efforts must focus not only on plant communities but also on their pollinating animal counterparts. Including pollinator-focused strategies in rehabilitation plans is crucial, particularly in areas that have experienced significant environmental degradation, such as post-industrial and mining landscapes. This study assessed insect and plant diversity across eight sites within the Silver Bow Creek/Butte Area Superfund site, located in southwestern Montana. The …


Conquer And Prevail Issue 169 August 8 2024, Wofford College. Office Of Marketing And Communications Aug 2024

Conquer And Prevail Issue 169 August 8 2024, Wofford College. Office Of Marketing And Communications

Conquer and Prevail Newsletter

No abstract provided.


Unh Research Offers Better Measurement For Lethal Impact Of Marine Heatwaves, Robbin Ray Aug 2024

Unh Research Offers Better Measurement For Lethal Impact Of Marine Heatwaves, Robbin Ray

Media Relations

No abstract provided.


Growth Response Of Tomatoes To Application Of Bacterial-Coated Npk Fertilizer In A Pot Experiment, Reginawanti Hindersah, Ruhnayati Kaffah, Ayu Siti Aisyah, Mieke Rochimi Setiawati, Mahfud Arifin Aug 2024

Growth Response Of Tomatoes To Application Of Bacterial-Coated Npk Fertilizer In A Pot Experiment, Reginawanti Hindersah, Ruhnayati Kaffah, Ayu Siti Aisyah, Mieke Rochimi Setiawati, Mahfud Arifin

Jurnal Kultivasi

Nitrogen-fixer and phosphate-solubilizer bacteria increase the chemical-fertilizer efficiency and soil health. Bacterial-coated NPK fertilizer is a novel approach for intensifying biofertilizer application in vegetable production. The study aimed to observe the compatibility between two Azotobacter species and two Bacillus species, their population on two formulations of bacterial-coated NPK fertilizer (BCN), and the effect of BCN dose on growth, N and P content, and their uptake in tomato shoots. The compatibility test was performed using the streak method. The population of Azotobacter and Bacillus were counted for two formulations of NPK fertilizer coated by solid biofertilizer (5% and 10%) and zeolite …


Veterinary Medical Board, Katie Gonzalez Aug 2024

Veterinary Medical Board, Katie Gonzalez

California Regulatory Law Reporter

No abstract provided.


Public Utilities Commission, Erol Kilic, Marcus Friedman Aug 2024

Public Utilities Commission, Erol Kilic, Marcus Friedman

California Regulatory Law Reporter

No abstract provided.


Enpp1 Enzyme Replacement Therapy Improves Ectopic Calcification But Does Not Rescue Skeletal Phenotype In A Mouse Model For Craniometaphyseal Dysplasia, Ernst Reichenberger, Kevin O'Brien, Ayano Hatori, Thomas Carpenter, Koen Van De Wetering, Lisa Flaman, Jennifer Howe, Daniel Ortiz, Yves Sabbagh, I-Ping Chen Aug 2024

Enpp1 Enzyme Replacement Therapy Improves Ectopic Calcification But Does Not Rescue Skeletal Phenotype In A Mouse Model For Craniometaphyseal Dysplasia, Ernst Reichenberger, Kevin O'Brien, Ayano Hatori, Thomas Carpenter, Koen Van De Wetering, Lisa Flaman, Jennifer Howe, Daniel Ortiz, Yves Sabbagh, I-Ping Chen

Jefferson Institute of Molecular Medicine Papers and Presentations

Craniometaphyseal dysplasia (CMD) is a rare genetic bone disorder, characterized by progressive thickening of craniofacial bones and flared metaphyses of long bones. Craniofacial hyperostosis leads to the obstruction of neural foramina and neurological symptoms such as facial palsy, blindness, deafness, or severe headache. Mutations in ANKH (mouse ortholog ANK), a transporter of small molecules such as citrate and ATP, are responsible for autosomal dominant CMD. Knock-in (KI) mice carrying an ANKF377del mutation (AnkKI/KI) replicate many features of human CMD. Pyrophosphate (PPi) levels in plasma are significantly reduced in AnkKI/KI mice. PPi is a potent inhibitor of …


Exploring The Role Of Rb1 In Cellular Differentiation Using Patient-Derived Stem Cells, Ambily Vincent Aug 2024

Exploring The Role Of Rb1 In Cellular Differentiation Using Patient-Derived Stem Cells, Ambily Vincent

Theses and Dissertations

The Retinoblastoma (RB1) gene, predominantly recognized as a tumour suppressor, plays a crucial role in early growth and development. Mice lacking the retinoblastoma gene do not survive and exhibit defects in the differentiation of various tissues, underscoring its involvement in cellular differentiation. This suggests that the functions of the RB1 gene extend beyond its role as a tumour suppressor, encompassing cell cycle regulation, maintenance of genomic stability, cellular senescence, and cellular differentiation.

While the tumour suppressor function of the RB1 has been extensively studied, its role in cellular differentiation remains incompletely understood. Existing literature, primarily based on animal models, has …


Is There Room In The Classroom For The First Amendment? Defining The Doctrine For Teachers’ Classroom Speech, J.P. Riley Aug 2024

Is There Room In The Classroom For The First Amendment? Defining The Doctrine For Teachers’ Classroom Speech, J.P. Riley

San Diego Law Review

Many public school teachers face a daunting question: What are they allowed to say in the classroom? States are actively passing legislation restricting instruction and discussion regarding Critical Race Theory, sexual orientation, and gender identity. Yet, there is a circuit split in First Amendment jurisprudence regarding the bounds of teachers’ classroom speech. Do these purported curricular restrictions extend to all teachers’ classroom speech? Do these restrictions silence teachers’ lived identities related to race, sexual orientation, and gender identity? The Supreme Court should resolve the circuit split in teachers’ classroom speech analysis to provide teachers the protection to share their lived …


Five A Day, The Rainbow Way: A Nutrition Education Toolkit For Elementary School Aged Children, Sasha Menard Aug 2024

Five A Day, The Rainbow Way: A Nutrition Education Toolkit For Elementary School Aged Children, Sasha Menard

Department of Nutrition Student Projects

Learning Outcome: Develop a nutrition educational toolkit based on Social Cognitive Theory (SCT) for obesity prevention among elementary school-aged children by improving determinants of fruit and vegetable intake.

Background: Poor consumption of fruits and vegetables is a major contributing factor to childhood obesity, increasing the risk for chronic diseases later in life. There is a need for multicomponent nutrition educational tools to influence children to improve their eating behavior by increasing their awareness and self-efficacy. The current project describes the development of a 3-component toolkit for improving participants’ knowledge and values related to fruit and vegetable intake among 6-11-year-olds.

Methods: …