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Patent Law And Access To Biotechnology, Enoch Otim

Technology and Economics Law Journal

The research analyzes the use of patents in a field other than industry and how they have a wider impact than the monetary gain of the patent holder. In recent years, patents have been taken out on organisms and gene sequences, which has a flow-on effect of jeopardizing any further research in that area and possible future developments. This is a serious issue in the fast-moving field of medical biotechnology. For example, researchers patented and developed a test that utilized and identified a gene sequence that was later patented by another party. The researchers may have to discontinue the test …

Micropatterning Of Biologically Derived Surfaces With Functional Clay Nanotubes, Nisha Lama

Doctoral Dissertations

In this study, we have generalized an assembly of 50 nm diameter clay nanotubes on larger 20-50 μm diameter biological microfibers such as human hair (protein), cotton (cellulose) and synthetic polyethylene terephthalate- PET. We developed a common set of parameters and nanoclay coating techniques on these naturally different microfibers. We exploited and optimized the electrostatic interaction of the components through strategic adjustments in the solvent pH, employing polycation treatment, as well as selectively modifying the halloysite nanotubes with silanes. For 5 mins, a 5 wt% aqueous dispersion of halloysite nanotubes were applied to get approximately 1-2 μm thick fiber coating …

Robotic Odor Source Localization Using Vision And Olfaction Sensing, Sunzid Hassan

Master's Theses

Robotic Odor Source Localization (ROSL) technology allows autonomous agents like robots to find an odor source in unknown environments. A successful odor source location depends crucially on an effective navigation algorithm that directs the robot towards the odor source. This thesis is a combination of three projects. First, we detail development of a versatile multi-modal robotic platform for ROSL real-world ROSL experimentation and discussed real-world validation of a traditional olfactionbased ROSL algorithm. Secondly, we introduced vision in ROSL by proposing a fusion navigation algorithm that integrates deep-learning enabled vision and olfaction-based navigation. This hybrid approach tackles challenges such as turbulent …

Inflammation, Physical Activity, And Disease-Free Survival In Stage Iii Colon Cancer: Calgb/Swog 80702 (Alliance), Justin C. Brown, Chao Ma, Qian Shi, Felix Couture, Philip Kuebler, Pankaj Kumar, Benjamin Tan, Smitha Krishnamurthi, Victor Chang, Richard M. Goldberg, Eileen M. O'Reilly, Anthony F. Shields, Jeffrey A. Meyerhardt

School of Medicine Faculty Publications

Background: Both inflammation and insufficient physical inactivity contribute to individual-level risk of disease recurrence and death in stage III colon cancer. The extent to which increased inflammatory risk can be offset by sufficient physical activity remains unknown. Methods: This cohort study was nested within the CALGB/SWOG 80702 (Alliance) randomized trial. Inflammatory burden was quantified by high-sensitivity C-reactive protein, interleukin-6, and soluble tumor necrosis factor-α receptor 2 after recovery from tumor resection. Physical activity was measured during and after postoperative chemotherapy. The primary endpoint was disease-free survival. Results: The 3-year disease-free survival rate was 88.4% among patients with low inflammation and …

The State Of Elementary School Recess In Georgia: Policy, The Pandemic, And Patterns Of Play, Karyn A. Alee, Erica Decuir, Dawn M. Robinson

Education Faculty Publications

While we continue to see a growing push for the restoration and codification of recess in elementary schools, policy does not necessarily equal practice. Georgia recently passed legislation requiring at least 20 minutes of recess per day for students in PK-5. The purpose of this research study was to survey elementary school educators to reveal the temporal (i.e., duration, frequency, and cancellation practices) and descriptive (i.e., type, equipment, place) characteristics of recess in Georgia’s public elementary schools. The results of this study, which can be summed up statistically and descriptively as less recess overall, and less free play specifically, as …

Chicago’S Migrant Serving Ecosystem: Perspectives From Providers On The Frontline, Safa S. Asad

College of Science and Health Theses and Dissertations

Global destabilization has resulted in nearly 110 million people forcibly displaced from their homes. Sanctuary cities like Chicago have become “migrant hubs,” seeing thousands of migrants enter the city to access shelter and resources. City officials have called for more support, as the number of migrants has outweighed the number of migrant service providers.

Migrant service organizations play an integral role in the resettlement journey of migrants. These organizations provide direct and indirect services to support their clients. However, as the migrant crisis continues to worsen, it threatens the social safety net established by governments and immigrant serving nonprofit agencies …

A Longitudinal Study Assessing The Influence Of Salivary Cortisol, Alpha Amylase, And Interleukin-1Β Levels On Sleep And Physical Activity Among Emerging Adults, Bernardo Loiacono

College of Science and Health Theses and Dissertations

Emerging adulthood can be marked by psychological disorders and distress. Stress exposure activates several bodily responses involving the hypothalamic pituitary axis (HPA) and autonomic nervous system (ANS). Research into these systems involves the examination of several biomarkers including cortisol and alpha amylase. Basal values of these biomarkers have been linked to well-being and health outcomes. Also, stress biomarkers have been shown to influence physical activity (PA) which is salient because it is linked to chronic illness and disease (e.g., obesity, cancer, depression, diabetes). The present study aimed to explore the bidirectional relationships between basal stress biomarkers and daily PA in …

Effects Of Receiving Peer-Status Feedback On Chinese Adolescents, Mingqi Li

College of Science and Health Theses and Dissertations

Previous research has demonstrated the negative impacts of social status insecurity on adolescents’ behavior and mental health. Hence, there is an urgency in exploring mechanisms that may alleviate adolescents’ concerns about their peer status. The present study is the first to 1) use an experimental design to examine the effect of providing feedback on adolescents’ peer status in an attempt to reduce or induce their social status insecurity and 2) investigate how these changes would influence adolescents’ immediate outcomes such as present mood, behavior intentions, and social status goals. Participants were 465 high school students (253 boys; M_age = …

Wolverine Habitat Suitability Analysis In Lake County, Colorado, Using Gis, Jake Hostnik

Geography and the Environment: Graduate Student Capstones

This project explores the reintroduction of the wolverine (Gulo gulo luscus) to Colorado’s mountainous regions, where the species has been extirpated due to habitat destruction and human activities. The study uses Geographic Information Systems (GIS) to identify optimal habitats for wolverine reintroduction, considering factors like snowpack duration, prey availability, and human disturbance. By creating a GIS-based habitat suitability model, this research will guide conservationists in selecting reintroduction sites. The project addresses the species' role in maintaining alpine ecosystem balance and contributes to the broader understanding of biodiversity restoration in the face of climate change. Results will inform future conservation planning …

Dental Modification Among The Classic Maya Of Chac Balam And San Juan, Ambergris Caye, Belize, Katherine Kelly

Honors Theses

Perceptions of beauty and health are embedded within everyday actions, even a simple smile. How do dental modification practices among the Classic Maya from Ambergris Caye, Belize relate to these perceptions and a person’s identity and status? This thesis analyzes the practice of notching, filing, and placing inlays in maxillary incisors and canines through a qualitative analysis of Classic period AD 250-1000 Maya teeth from the sites of San Juan and Chac Balam. A lack of patterns related to sex, socioeconomic status, and the type of modification in the dentition of five individuals, including two males, two females and one …

Slow Ramping Emerges From Spontaneous Fluctuations In Spiking Neural Networks, Jake Gavenas, Ueli Rutishauer, Aaron Schurger, Uri Maoz

Psychology Faculty Articles and Research

The capacity to initiate actions endogenously is critical for goal-directed behavior. Spontaneous voluntary actions are typically preceded by slow-ramping activity in medial frontal cortex that begins around two seconds before movement, which may reflect spontaneous fluctuations that influence action timing. However, the mechanisms by which these slow ramping signals emerge from single-neuron and network dynamics remain poorly understood. Here, we developed a spiking neural-network model that produces spontaneous slow ramping activity in single neurons and population activity with onsets ~2 s before threshold crossings. A key prediction of our model is that neurons that ramp together have correlated firing patterns …

Improved High Quality Sand Fly Assemblies Enabled By Ultra Low Input Long Read Sequencing, Michelle Huang, Sarah Kingan, Douglas Shoue, Oanh Nguyen, Lutz Froenicke, Brendan Galvin, Christine Lambert, Ruqayya Khan, Chirag Maheshwari, David Weisz, Gareth Maslen, Helen Davison, Erez Lieberman Aiden, Jonas Korlach, Olga Dudchenko, Mary Ann Mcdowell, Stephen Richards

Faculty, Staff and Students Publications

Phlebotomine sand flies are the vectors of leishmaniasis, a neglected tropical disease. High-quality reference genomes are an important tool for understanding the biology and eco-evolutionary dynamics underpinning disease epidemiology. Previous leishmaniasis vector reference sequences were limited by sequencing technologies available at the time and inadequate for high-resolution genomic inquiry. Here, we present updated reference assemblies of two sand flies, Phlebotomus papatasi and Lutzomyia longipalpis. These chromosome-level assemblies were generated using an ultra-low input library protocol, PacBio HiFi long reads, and Hi-C technology. The new P. papatasi reference has a final assembly span of 351.6 Mb and contig and scaffold N50s …

Considerations For Interviewing And Intervening With Suicidal Gender Expansive Individuals, Abigail Herrold

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

It has been well documented that transgender individuals are at a higher risk for death by suicide compared to their cisgender peers. However, limited consideration has been given to studying suicidality in individuals who identify outside of the gender binary (non-binary, gender queer, gender fluid, etc.). Additionally, while there is considerable evidence for risk factors for suicide and protective factors against suicide, there is a lack of guidance on how to implement this information. The aim of this paper is to expand upon the literature of research that is inclusive of all gender identities and propose guidelines working with gender …

Turkey Tail Mushroom (Trametes Versicolor): An Edible Macrofungi With Immense Medicinal Properties, Olaide Olaide Ajibola, Cirilo Nolasco-Hipolito, Octavio Carvajal-Zarrabal, Shanti F. Salleh, Gbadebo C. Adeyinka, Stephen A. Adefegha, Mirja K. Ahmmed, Kazi Sumaiya, Raymond Thomas

Biology Publications

Macrofungi, commonly known as mushrooms, are not only considered functional foods for supplying essential nutritional ingredients but also a good source of physiologically beneficial medicines. Trametes versicolor, referred to as turkey tail’s Mushroom or Yun Zhi in China, is an edible mushroom that has extensive historical usage in conventional and traditional Chinese medicine. This mushroom contains an abundance of physiologically bioactive compounds, most notably β-glucan polysaccharides, which are responsible for antioxidant, neuroprotection, hypolipidemic effects, immune-modulating effects, and anticancer effects. Trametes versicolor has also been revealed to have wound healing, antidiabetic, antimicrobial, antifibrotic, neurotrophic, and …

An Accidental Discovery Of Ductal Adenocarcinoma Of The Pancreas In An Adult Horse With Severe Abdominal Pain, Thita Wonghanchao, Kanokpan Sanigavatee, Chanoknun Poochipakorn, Onjira Huangsaksri, Phudit Maneesaay, Rungrueang Yodsheewan, Metha Chanda

The Thai Journal of Veterinary Medicine

A native pony, eight years old and male, was tentatively diagnosed with abdominal pain and treated immediately. Sequential hematological profiles revealed increased levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatinine, as well as reduced albumin. After the pony's death, which occurred eight days after treatment began, a necropsy was performed. The liver's external surface showed small foci, but no gross lesion was observed in the pancreas, which was enlarged. Haematoxylin and eosin (H&E) staining of the liver showed multifocal inflammation in the hepatic parenchyma, coinciding with bile duct hyperplasia. The pancreas H&E staining showed well-differentiated tubular glands with …

Southern Adventist University Commencement Program Summer 2024, Southern Adventist University

Commencement Programs

Program for Southern Adventist University Summer 2024 graduation. The commencement service occurred on August 23, 2024 at 10 am in Iles Physical Education Center.

2024 Ursinus College Academic Convocation Program, Ursinus College

Academic Convocation Programs

This Ursinus College Academic Convocation program lists speakers and events for the opening of the 2024 academic year.

Accessible Dietary Interventions For The Prevention And Management Of Common Menstrual Disorders: A Systematic Review, Ella R. Motzko

Theses and Graduate Projects

Objective: This systematic review aims to provide healthcare providers with evidence-based dietary recommendations that can be easily implemented by patients across diverse populations to address a critical gap in the management of common menstrual disorders like premenstrual syndrome (PMS) and primary dysmenorrhea (PD).

Methods: A comprehensive search was conducted using UpToDate, American College of Obstetrics and Gynecology (ACOG) Green Journal, Google Scholar, and PubMed electronic databases to identify randomized-controlled trials (RCTs) that investigated the effects of specific essential nutrients or diet-related behavioral or educational interventions on PMS or PD symptoms.

Results: Following the PRISMA guidelines, the identification process began with …

The College Of Science, Technology, And Health Welcomes New Faculty, Lindenwood University

Archived Lindenwood Press Releases

No abstract provided.

On The Formation And Detectability Of H2Cncn And Its Progenitors, Ryan C. Fortenberry, Vincent J. Esposito

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

New highly exothermic formation pathways incorporating both thermodynamic and kinetic control for the newly astronomically detected H₂CNCN molecule are paired with extremely accurate quantum chemical rovibrational spectroscopic computations. The reactions between astronomically known CH₂CN/CH₂CCH + HNCN follow effectively identical pathways and proceed through stable intermediates and over deeply submerged transition states to form H₂CNCN and HCN/HCCH coproducts. Similarly, the reaction between CHM₂CN and NCN⁻ can also form H₂CNCN, although this pathway first requires the initial formation of NCN⁻, which is currently undetected in space, via …

Technical Note: Assessing Gps Sensor Accuracy Using Real-Time Kinematic Device For Livestock Tracking, Biquan Zhao, Rebecca Mcdermott, Galen E. Erickson, Yijie Xiong

Department of Animal Science: Faculty Publications

The technical aspects of global positioning system (GPS) sensors have been improved substantially over the years, making them valuable and popular tools for livestock tracking. Using GPS sensors allows producers and researchers to locate grazing livestock, monitor their behavior and distribution, and gather referencing information about the health status of the animals and pastures. However, interpreting the behavior of grazing livestock, such as cattle, from GPS data can be difficult due to positioning inaccuracies. Without knowing the positioning accuracy range of GPS sensors, achieving high-level confidence in determining grazing densities and identifying abnormal livestock movement patterns is challenging. …

Partition Between Supercooled Liquid Droplets And Ice Crystals In Mixed-Phase Clouds Based On Airborne In Situ Observations, Flor Vanessa Maciel, Minghui Diao, Ching An Yang

Faculty Research, Scholarly, and Creative Activity

The onset of ice nucleation in mixed-phase clouds determines the lifetime and microphysical properties of ice clouds. In this work, we develop a novel method that differentiates between various phases of mixed-phase clouds, such as clouds dominated by pure liquid or pure ice segments, compared with those having ice crystals surrounded by supercooled liquid water droplets or vice versa. Using this method, we examine the relationship between the macrophysical and microphysical properties of Southern Ocean mixed-phase clouds at − 40 to 0 °C (e.g. stratiform and cumuliform clouds) based on the in situ aircraft-based observations during the US National Science …

Analysis Of Networks Using Hypergraph Centrality Measures And Other Properties, Sathyanarayanan G

Theses and Dissertations

Network analysis explores the connections between nodes and evaluates their characteristics across diverse fields such as biological, chemical, social networks and so on. Identifying key nodes within a network is crucial for grasping how information spreads, which has significant applications across multiple fields. This includes studying disease transmission, managing rumours, understanding social leadership, enhancing viral marketing strategies, and monitoring public opinion. Influential nodes play a pivotal role in effectively distributing information throughout the network. The centrality measures are paramount in network analysis that uses various metrics to evaluate the importance of the node. The centrality predicts the characteristics and significance …

Optogenetic Control Of Bacterial Dormancy, Yousr Dhaouadi Khattab

Dissertations - ALL

The presence of persister cells makes it difficult to eradicate chronic bacterial infections as these dormant subpopulations arise with exposure to stressors and are capable of surviving antimicrobials that target active cells. Persisters can also revert back to normal growing cells when stressors are removed thus reestablishing the infection. It is therefore important to understand the underlying mechanisms of persister formation, as well as wake-up, and target these systems in order to treat chronic bacterial infections. The formation of persisters, however, remains elusive as there is not yet a clear relationship between the various stages of dormancy. Persister cells can …

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

Correlation Between Plasma Ccfdna, Mtdna Changes, Ctcs, And Epithelial-Mesenchymal Transition In Breast Cancer Patients Undergoing Nact, Betül Çeli̇k, İrem Peker Eyüboğlu, Si̇nan Koca, Mustafa Ümi̇t Uğurlu, Özkan Alan, Gökçe Güllü Amuran, Tuğba Akin Telli̇, Fulden Yumuk, Mustafa Akki̇pri̇k

Turkish Journal of Medical Sciences

Background/aim: Breast cancer is the most prevalent cancer in women, emphasizing need for noninvasive blood biomarkers to aid in treatment selection. Previous studies have demonstrated elevated levels of plasma circulating cell-free DNA (ccfDNA) in breast cancer patients. Both ccfDNA and mitochondrial DNA (mtDNA) are fragments released into the bloodstream. In this study, we investigated effectiveness of ccfDNA and mtDNA as indicators of treatment response and explored their potential as monitoring biomarkers. Additionally, we compared these markers with circulating tumor cell (CTC) data and assessed their relationship with epithelial-mesenchymal transition (EMT).Materials and methods: Thirty-six female breast cancer patients and 21 healthy …

Can Prothrombotic Gene Variants And Apoa1 Rs5069 Polymorphism Be The Predictors Of Early Myocardial Infarctions?, Hüseyi̇n Balcioğlu, Eli̇f Fatma Özkan Pehli̇vanoğlu, Uğur Bi̇lge, Kadi̇r Uğur Mert, Muhammet Dural, Ebru Erzurumluoğlu Gökalp, Oğuz Çi̇li̇ngi̇r, Sevi̇lhan Artan

Turkish Journal of Medical Sciences

Background/aim: We aimed to determine the genetic risk factors in the patients (45 years and below) who had early myocardial infarction history in comparison with the people who had no MI over 60 years of age.Material and method: In this study, we chose different age groups to distinguish genetic differences more clearly. Accordingly, we compared those who had MI at an early age with those who were older and did not experience any cardiovascular events. While 99 volunteers under the age of 45 with a history of MI were included as the patient group, 99 volunteers aged 60 and over …

Serum Vascular Endothelial Growth Factor Has Diagnostic And Prognostic Significiances In Ulcerative Colitis, Musa Salmanoğlu, İrfan Küçük, Başak Çakir Güney, Betül Doğanteki̇n, Nurgül Tükel, Zeli̇ha Seri̇ndağ, Habi̇p Yilmaz, Mustafa Kaplan

Turkish Journal of Medical Sciences

Background/aim: In ulcerative colitis (UC), serum vascular endothelial growth factor (sVEGF) concentrations are elevated and there are conflicting results about serum calprotectin (SCP) and sVEGF as biomarkers. We aimed to evaluate the relationship between sVEGF and SCP levels in UC patients, and the associations of these molecules and the phenotypes of UC. Materials and methods: This prospective case-control study included 60 UC patients and 30 healthy controls. The Mayo Clinical Scoring System (MCS) was used for patients' clinical and endoscopic features (MES). Truelove and Richard's method was applied to the histology activity index (HAI). The human VEGF (Cat.E0080Hu) and the …

Investigation Of The Status Of Immune Checkpoint Molecules (Pd-L1 And Pd-1) In Meningiomas By Immunohistochemistry, İsmai̇l Saygin, Emel Çakir, Seher Nazli Kazaz, Ali̇ Riza Güverci̇n, İlker Eyüpoğlu, Müşerref Müge Ustaoğlu

Turkish Journal of Medical Sciences

Background/aim : Meningiomas are the most common primary brain tumors of the central nervous system. Immunotherapy is a promising treatment method applied in many types of cancer. There is no standard and effective medical treatment to reduce recurrence and mortality in cases of incomplete resection of meningiomas and in high-grade cases. In order to investigate medical treatments in addition to surgery and radiotherapy, in this study, the status of immune checkpoint molecules (PD-L1/PD-1), which are the target of immunotherapy, in meningiomas was investigated.Materials and Methods: Four hundred two cases of meningioma diagnosed between 2007 and 2020 in our institution were …

The Sharp Edge Of Immunosuppressive Treatments: Infections, Aybegüm Özşahi̇n, Tuba İlgar, Sudem Mahmutoğlu Çolak, Kübra Akyüz, Meli̇h Gaffar Gözükara, Uğur Kostakoğlu, İlknur Esen Yildiz, Ayşe Ertürk

Turkish Journal of Medical Sciences

Background and aim: Different side effects, including infections, are encountered in patients receiving anticytokines used for the treatment of severe coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the infections and the effects of these infections that develop in this patient group. Materials and Methods: This study included 208 patients who were followed-up with the diagnosis of severe COVID-19 in two different hospitals. Patient data were obtained retrospectively from the hospital information system. Results: Of the 208 patients included, 54 were in the anakinra group, and 154 were in the tocilizumab group. Of these patients, 73 …