Digital Commons Network^™

The Epigenetic Impact Of Dietary Choline On Growth Outcomes Of Children Exposed To Gestational Diabetes Mellitus, Ismail Kadam

Dissertations, Theses, and Capstone Projects

Maternal insulin resistance and hyperglycemia lead to gestational diabetes mellitus (GDM) which can cause fetal hyperinsulinemia, ultimately leading to excessive fetal growth associated with macrosomia and increased adiposity at birth. Increased placental macronutrient transport and epigenetic changes in growth and metabolic genes affected by GDM contribute to fetal overgrowth and can result in complications such as overweight/obesity, insulin resistance/type 2 diabetes, cardiovascular disease risk factors, as well as cognitive impairment later in life. Choline, an essential nutrient, participates in lipid and energy metabolism by providing methyl groups for DNA methylation and thus may overcome the hypomethylation of growth and metabolic …

“Hattak Vpi Homma” Mvt Miha Nanta Fehna? What Does “Native American” Really Mean?, Alex R. Steers-Mccrum

Dissertations, Theses, and Capstone Projects

Indigenous identities in North America are much more complex than generally assumed. No single definition of “Native (American),” “(American) Indian,” or related terms provides a set of necessary and sufficient conditions that accurately or usefully describe all and only the right individuals and communities. I argue that understanding Native identities in the contemporary context requires examining multiple interconnected dimensions of Nativeness, articulated here as Enrollment and Recognition, Tribal Ethnicities, Native Race, Indian Panethnicity, and Indigenous Nationhood.

In the U.S., Indigenous identities are usually oversimplified as either Enrollment in a Recognized Tribe or as Native Race. While both of these aspects …

Competitive And Noncompetitive Credit Assignment To Reward Cues In The Lateral Orbitofrontal Cortex, Mihwa Kang

Dissertations, Theses, and Capstone Projects

This dissertation investigates the mechanisms underlying variations in credit assignment to reward cues, with a focus on the lateral orbitofrontal cortex (lOFC). The lOFC has long been implicated in signaling reward expectancies, with controversy as to whether it signals the economic value of future outcomes, their sensory features to guide behavior or both. However, whether the lOFC signals the relative (competition-dependent) or absolute (contiguity-dependent) credit of cues is unknown. To address this, I employed a combination of novel behavioral assays, in-vivo electrophysiological recordings and optogenetic stimulation in rats. In Chapter 2, I tested the suitability of a self-initiating variant of …

Green Synthesis Of Nanocomposite: Based On [Eugenol And Metal Oxides], Characterization And Biomedical Applications, Fatin A. Abd Al-Qadir, Basim I. Al-Abdaly

Baghdad Science Journal

Eugenol (EUG) was reacted as a matrix with a mixture of metal oxides (ZnO and CuO) have been prepared from metal acetate, Zn (CH3CO2)2 and Cu (CH3CO2)2 as precursors and using ethylene glycol (EG) as a solvent for synthesis the [Eug/ ZnO: CuO] nanocomposite using Sol-Gel method. The synthesized nanocomposite was characterized using techniques (FT-IR, AFM, SEM, EDX, and XRD), where the average particle diameter was found to be within the nanoscale range. It was also observed that the prepared nanomaterial was in the form of rods with good homogeneity distribution. In order to stand on the obtained nanoscale properties, …

Sensitive Determination Of Hydrochlorothiazide Drug In The Various Samples Via Developed Method Of Cfia System, Wasan A. Hanooan, Bushra B. Qassim

Baghdad Science Journal

Hydrochlorothiazide drug determination in pharmaceutical and biological urine samples using a novel continuous flow-injection analysis technique that is rapid, simple, economical, and sensitive. The complex formed by the reaction of hydrochlorothiazide and O-phenylenediamine with potassium ferricyanide to produce an orange-colored product at 480 nm was the basis for the proposed method. Other chemical and physical parameters that affect the stability and development of the colored product used in this developed method includes sample volume, flow rate, reagent concentrations, and reaction coil. The proposed method’s linearity ranges from 5 to 150 μg.mL-1 and its correlation coefficients were 0.9988, and the recovery …

Synthesis, Characterization And Antimicrobial Activity Of New 4-Aminoantipyrine Derivatives Using Ultrasonic Mediation, Naween M. Youns

Baghdad Science Journal

A straightforward, one-pot, three-component reaction between substituted aromatic aldehydes, 2-naphthol and 4- aminoantipyrine have been used to synthesis a series of new 4-(((2-hydroxynaphthalen-1-yl) (phenyl) methylene) amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one derivatives (A1- A5). This reaction was carried out with zirconyl chloride (ZrOCl2.8H2O) as an efficient catalyst under the condition of ultrasound irradiation. The fact that these derivatives have the potential to act as building blocks in the production of new compounds makes them very essential 4-(1-phenyl-1H-naphtho[1,2-e] [1,3] oxazin-2(3H)-yl)- 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one derivatives (A6, A7 and A8). Likewise, the MCRs that resulted in the formation of hetero cyclic compound (1,3-naphthoxazine) and included 4-aminoantipyrine, formaldehyde, and 2-naphthol in …

Graphene Oxide Decorated With Nickel Cobaltite Nanoparticles As An Adsorbent For Cationic Methyl Green Dye: Kinetic, Isotherm, And Thermodynamic Studies, Maryam Abdulsatar Abduljabar, Sundus Hadi Merza

Baghdad Science Journal

In this study, graphene oxide (GO) flakes were embellished with NiCo2O4 ‎‎(NC) nanoparticles by in situ deposition, and the produced composite (NC: ‎GO) was utilized as an adsorbent to remove methyl green dye (MG) from aqueous ‎solutions. The successful coating of graphene oxide with nickel cobaltite ‎nanoparticles (NC) was verified using FT-IR, SEM and X-ray diffraction (XRD) studies. ‎The crystalline particle sizes of NC nanoparticles and NC nanoparticles decorated ‎GO were 10.53 nm and 9.30 nm respectively. The impact of several experimental ‎factors, including time of contact, the dosage of adsorbent, and temperature were ‎investigated. The optimal contact time and …

Microbiological And Analytical Evaluation Of Semi-Solid Formulations Of Doxycycline Hyclate Under Accelerated Stability Conditions, Ola Aasi, Youssef Alahmad, Mustafa Beesh, Amin Swed

Baghdad Science Journal

Doxycycline Hyclate (DOX) is a broad-spectrum antibiotic that belongs to the tetracycline family. It has been widely used in the treatment of several inflammatory diseases, and is considered the first-line therapy in the management of moderate to severe cases of acne. In this research, Doxycycline was formulated in four semi-solid formulations (F1and F2 as Gels, F3 and F4 as ointments), then these formulations were subjected to accelerated stability conditions for three months. The formulations were evaluated using microbiological and analytical methods after one and three months. Agar well diffusion method was used as a microbiological method to screen the antibacterial …

Isolation And Identification Of Flavonoid Compounds From Euphorbia Milii Plant Cultivated In Iraq And Evaluation Of Its Genetic Effects On Two Types Of Cancer Cell Line, Z. O. Salman, Bushra M.J. Alwash, E. J. Kadhim

Baghdad Science Journal

The "crown of thorns" or Euphorbia milii, a decorative and therapeutic plant species, is regarded as belonging to the genus Euphorbia. E. milii is abundant in phenolic compounds, terpenoids, steroids and alkaloids. The main objective of this study was to investigate the extracted flavonoid and nano-flavonoids against two types of cell lines. Nano-flavonoids were synthesized via chitosan-maleic complex reaction. The structure of nano-flavonoids was analyzed by UV-sp -8001 spectrophotometer with a 200–1000 nm scanning wavelength and the produced compounds were examined. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) are used to determine the morphological properties. A strong and …

The Association Of Glycated Hemoglobin And Lipid Profile With Peripheral Artery Disease In Metabolic Syndrome Patients From Northwestern Algeria, Imane Bouragba, Mustapha Diaf, Sarra Souiah, Asmaa Melih, Attouya Mellali

Baghdad Science Journal

Glycated hemoglobin (HbA1c) was incorporated as an indicator of dysglycemia, as opposed to fasting glycaemia, for the purpose of classifying patients based on their vascular incidents. This choice was made due to HbA1c's robust correlation with vascular factors like pulse wave velocity, intima media thickness, and the albumin/creatinine ratio (ACR). However, the relationship between HbA1c and lipid profile in developing artery disease remain uncertain. We set out to investigate the association of HbA1c and lipid profile with peripheral artery diseases (PAD) in patients with metabolic syndrome (MetS) in north-western Algeria. Our cross sectional study was carried out during six months. …

Effect Of Biotic And Abiotic Elicitors On Salvadora Persica Callus In Vitro, Hadaia Y. Jasim, Hadeel M. Habeeb

Baghdad Science Journal

The research was conducted to study the effect of different concentrations of nanoparticles (chitosan and titanium dioxide) of Fusarium oxysporum as elicitors to increase the production of active compounds from Salvadora persica callus. Determine the total flavonoids and alkaloids rustle that chitosan in 5 mg/L, titanium dioxide in 1 mg/L, and Fusarium oxysporum in 5 mg/L give 93.10 mg100mg, 128.7 mg/100mg, and 107.61 mg/100mg respectively whereas alkaloids give 2.39%, 3.91%, and 2.20 % respectively. The results showed superiority in the presence of flavonoids in the samples compared with alkaloids. HPLC (High-performance liquid chromatography) analysis shows significant differences in increasing flavonoid …

Effects Of Oxycodone On Placental Lineages: Evidence From The Transcriptome Profile Of Mouse Trophoblast Giant Cells, Zhen Lyua, Jessica A. Kinkadeb, Nathan J. Bivens, R. Michael Roberts, Trupti Joshi, Cheryl S. Rosenfeld

Biomedical Sciences

Pregnant women are often prescribed or abuse opioid drugs. The placenta is likely the key to understanding how opioids cause adverse pregnancy outcomes. Maternal oxycodone (OXY) exposure of pregnant mice leads to disturbances in the layer of invasive parietal trophoblast giant cells (pTGC) that forms the interface between the placenta and uterus. These cells are analogous to extravillous trophoblasts of the human placenta. They are crucial to coordinating the metabolic needs of the conceptus with those of the mother and are primary participants in the placenta–brain axis. Their large nuclear size, however, has precluded both single- cell (sc) and single- …

Stem Rust And Its Management In Wheat, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Stem rust (Puccinia graminis f. sp. tritici) is a foliar disease that can significantly reduce wheat yields if it occurs in early spring and is not controlled. Risk factors, management strategies (including variety choices and foliar fungicides), and yield loss from different varieties are discussed here.

In Western Australia, stem rust typically causes losses of 10 to 50% in wheat, but this can increase to 90% when it occurs in early spring and is not controlled.

Stem rust affects wheat and triticale, but barley can also be a host during summer months.Stem rust produces large, reddish-brown spore masses on both …

Novel Psychoplastogen Dm506 Reduces Cue-Induced Heroin-Seeking And Inhibits Tonic Gaba Currents In The Prelimbic Cortex, Kassandra Looschen, Shailesh N. Khatri, Malabika Maulik, Colin Salisbury, Alaina F. Carman, Katilyn Corriveau, Colton Smith, Dina Manetti, Maria Novella Romanelli, Hugo R. Arias, Cassandra D. Gipson, Swarup Mitra

Markey Cancer Center Faculty Publications

Opioid use disorder is a major public health crisis that is manifested by persistent drug-seeking behavior and high relapse frequency. Most of the available treatments rely on targeting opioid receptors using small molecules that do not provide sustained symptom alleviation. Psychoplastogens are a novel class of non-opioid drugs that produce rapid and sustained effects on neuronal plasticity, intended to produce therapeutic benefits. Ibogalogs are synthetic derivatives of iboga alkaloids that lack hallucinogenic or adverse side effects. In the current study, we examine the therapeutic potential of DM506, a novel ibogalog lacking any cardiotoxic or hallucinogenic effects, in cue-induced seeking behavior …

Complete Genome Sequence Of An Indian Outbreak Strain Of Chikungunya Virus, Eshna Laha, Deepak Jena, Viplov K. Biswas, Sharad Singh, Sunil K. Raghav, Asit K. Pattnaik, Soma Chattopadhyay

Nebraska Center for Virology: Faculty Publications

Here, we report the complete genome sequence of an Indian strain of chikungunya virus isolated from an infected patient from Hyderabad, Andhra Pradesh, India, during a massive outbreak in 2005–2006. The genome length spans 11,811 nucleotides and has a poly(A) tail of 29 residues at the 3′ end.

Study Of Life History Traits Of Culex Pipiens Linnaeus, 1758 (Diptera: Culicidae) In Laboratory In Erbil Province In Kurdistan Region-Iraq, Dlpak Birkhader Yaba, Shamall Abdulla Al-Muffti

Polytechnic Journal

This study aimed to study some biological aspects of different stages of Culex pipiens Linnaeus, 1758 in a laboratory that gathered randomly from four regions in Iraq's Kurdistan from Erbil. The results of the current study revealed that the eggs were laid in rafts, and the egg was elongated in shape, which was narrowed in one end. The mean number of laid eggs was 187.4 eggs; the mean hatching percentage was 83.07%, and the mean incubation period was 28.3 hours. The mean length of the first, second, third, and fourth larval instar was 2.21, 3.27,4.72, and 5.73 mm, respectively. The …

Machine Learning Techniques For Monitoring Water Quality In Water Resources, Hussam Hashim Hussein, Salam Muhsin, Wissam Shaya Abbas

Iraqi Journal of Computers, Communications, Control and Systems Engineering

More than 66% of the Earth's total surface area is covered by water. Cleanwater is one of the basic needs of everyday life. Consistent pollution of water bodies canhave far-reaching effects on the lives of living organisms. The World Health Organizationhas reported that the provision of safe drinking water for human consumption is achallenge that has reached alarming levels. This is because nearly 70% of the total waterwithdrawals worldwide are used in agriculture. To determine the water's suitability forhuman consumption, Tests are typically conducted by examining the properties of water interms of physical, biological, and chemical conditions. There are various …

Biological Studies Of The Activity Of Manuka Honey Against Carbapenem-Resistant Enterobacterales (Cre) Bacteria, Mamdouh A. Bukhari, Razaz A. Qamash, Rasha A. Bulkhi, Jehad A. Bifari, Omar S. Bakhsh, Khalid O. Hawsawi, Ehab Y. Matuure, Kamil A. Sulaimani, Ashwaq T. Hakim, Maher S. Mujahid

Saudi Medical Journal

Objectives: To evaluate the potency of Manuka honey UMF +15 against Carbapenem-resistant Enterobacterales (CRE). Bacterial resistance is a worldwide problem that is increasing year by year, especially Carbapenem resistance. Alternatives to antibiotics are needed to both reduce costs, and to reduce the spread of antibiotic resistance, with the ultimate goal of saving lives. Methods: The efficacy of Manuka honey UMF +15 was tested by 2 methods; Well diffusion assay and minimum bactericidal concentration (MBC) against twenty Carbapenem-resistant isolates which collected from Makkah city hospitals during three months of study from 1st of September 2023 up to 1st of December 2023. …

Middle East Immunology Summit Of The Gulf Cooperation Council Association Of Immunology And Rheumatology (Gcc Air), 2023 Dubai, United Arab Emirate. Scientific Abstracts And Case Reports, Ahmed S. Zayat, Saadeya Naji, Omar Syed, Adeeba Al-Herz, Ahmed Elasareeri, Mira Merashli, Mahdi Abusalameh, Waleed Hafiz, Elsadeg Sharif, Martin Lee, Fahdah Alokaily, Suad Hannawi

Saudi Medical Journal

No abstract provided.

Episodes Of Acute Methotrexate-Related Neurotoxicity Linked To Compromised Long-Term Neurocognitive Function, Rachel D Harris, Olga A Taylor, Kimberly P Raghubar, Mariana Matheus Gonzalez, Mark Zobeck, M Monica Gramatges, Karen R Rabin, Michael E Scheurer, Austin L Brown

Faculty, Staff and Students Publications

Methotrexate is a critical component of curative chemotherapy for pediatric acute lymphoblastic leukemia (ALL), but is associated with neurotoxicity. Information on long-term outcomes following an acute neurotoxic event is limited. Therefore, this report compares neurocognitive performance more than 12 months post diagnosis (mean = 4 years) between ALL patients with (n = 25) and without (n = 146) a history of acute neurotoxicity. Compared to children with no documented on-treatment neurotoxic event, children who experienced a neurotoxic event during treatment exhibited poorer performance on measures of fine motor function (p = .02) and attention (p = .02). Children with ALL …

Initiation Of Metformin In Early Pregnancy Results In Fetal Bioaccumulation, Growth Restriction, And Renal Dysmorphology In A Primate Model, Erin Bolte, Tyler Dean, Brandon Garcia, Maxim D Seferovic, Kristin Sauter, Gwendolynn Hummel, Matthew Bucher, Feng Li, John Hicks, Xuan Qin, Melissa A Suter, Enrico R Barrozo, Michael Jochum, Cynthia Shope, Jacob E Friedman, Maureen Gannon, Stephanie R Wesolowski, Carrie E Mccurdy, Paul Kievit, Kjersti M Aagaard

Faculty, Staff and Students Publications

Background: In recent years, pragmatic metformin use in pregnancy has stretched to include prediabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus, and (most recently) preeclampsia. However, with its expanded use, concerns of unintended harm have been raised.

Objective: This study developed an experimental primate model and applied ultrahigh performance liquid chromatography coupled to triple-quadrupole mass spectrometry for direct quantitation of maternal and fetal tissue metformin levels with detailed fetal biometry and histopathology.

Study design: Within 30 days of confirmed conception (defined as early pregnancy), 13 time-bred (timed-mated breeding) Rhesus dams with pregnancies designated for fetal necropsy were initiated on …

Determining Predictors Of Actual Living Kidney Donation Based On Potential Donor Characteristics, Andrea M Meinders, Edward A Graviss, Duc T Nguyen, Jonathan Daw, Krista L Lentine, John Devin Peipert, Ahmed Osama Gaber, David A Axelrod, Francis L Weng, Amy D Waterman

Faculty, Staff and Students Publications

Background: Living donor kidney transplantation is the optimal treatment for end-stage kidney disease; however, few living donor candidates (LDCs) who begin evaluation actually donate. While some LDCs are deemed medically ineligible, others discontinue for potentially modifiable reasons.

Methods: At five transplant centers, we conducted a prospective cohort study measuring LDCs' clinical and psychosocial characteristics, educational preparation, readiness to donate, and social determinants of health. We followed LDCs for 12 months after evaluation to determine whether they donated a kidney, opted to discontinue, had modifiable reasons for discontinuing, were medically ineligible, or had other recipient-related reasons for discontinuing.

Results: Among 2184 …

Molecular Detection Of Intestinal Parasites In A Rural Community Of Colombia: A One Health Approach To Explore Potential Environmental-Zoonotic Transmission, Sergio Castañeda, Claudia Patricia Acosta, Luis Reinel Vasquez-A, Luz H Patiño, Rojelio Mejía, Juan David Ramírez

Faculty, Staff and Students Publications

Aims: Protozoan and helminth parasitic infections pose significant public health challenges, especially in developing countries with rural populations marked by suboptimal hygiene practices and socio-economic constraints. The parasites are the etiological agents of these infections and have a notably elevated global prevalence. Therefore, this study focuses on estimating the frequency and transmission dynamics of several parasitic species, including Blastocystis, Giardia, Cryptosporidium spp., Entamoeba histolytica, Ascaris lumbricoides, Trichuris trichiura, Taenia spp. and hookworms, within a rural community in southwest Colombia with a particular emphasis on the One Health framework, considering environmental and zoonotic transmission potentials.

Methods and results: This study involved …

Enterococcus Faecalis-Derived Adenine Enhances Enterohaemorrhagic Escherichia Coli Type 3 Secretion System-Dependent Virulence, Fernando H Martins, Thibaut Rosay, Anubama Rajan, Hannah E Carter, Tayah Turocy, Andres Mejia, Jason M Crawford, Anthony W Maresso, Vanessa Sperandio

Faculty, Staff and Students Publications

Interactions between microbiota and enteric pathogens can promote colonization resistance or enhance pathogenesis. The pathobiont Enterococcus faecalis increases enterohaemorrhagic E. coli (EHEC) virulence by upregulating Type 3 Secretion System (T3SS) expression, effector translocation, and attaching and effacing (AE) lesion formation on enterocytes, but the mechanisms underlying this remain unknown. Using co-infection of organoids, metabolomics, supplementation experiments and bacterial genetics, here we show that co-culture of EHEC with E. faecalis increases the xanthine-hypoxanthine pathway activity and adenine biosynthesis. Adenine or E. faecalis promoted T3SS gene expression, while transcriptomics showed upregulation of adeP expression, which encodes an adenine importer. Mechanistically, adenine relieved …

Altered Extracellular Matrix-Related Pathways Accelerate The Transition From Normal To Prefibroid Myometrium In Black Women, Maria Victoria Bariani, Sandra L Grimm, Cristian Coarfa, Digna R Velez Edwards, Qiwei Yang, Cheryl L Walker, Mohamed Ali, Ayman Al-Hendy

Faculty, Staff and Students Publications

Background: Black women experience a disproportionate impact of uterine fibroids compared to White women, including earlier diagnosis, higher frequency, and more severe symptoms. The etiology underlying this racial disparity remains elusive.

Objective: The aim of this study was to evaluate the molecular differences in normal myometrium (fibroid-free uteri) and at-risk myometrium (fibroid-containing uteri) tissues in Black and White women.

Study design: We conducted whole-genome RNA-seq on normal and at-risk myometrium tissues obtained from both self-identified Black and White women (not Hispanic or Latino) to determine global gene expression profiles and to conduct enriched pathway analyses (n=3 per group). We initially …

Disruption Of Fuz In Mouse Embryos Generates Hypoplastic Hindbrain Development And Reduced Cranial Nerve Ganglia, Carlo Donato Caiaffa, Yogeshwari S Ambekar, Manmohan Singh, Ying Linda Lin, Bogdan Wlodarczyk, Salavat R Aglyamov, Giuliano Scarcelli, Kirill V Larin, Richard H Finnell

Faculty, Staff and Students Publications

Background: The brain and spinal cord formation is initiated in the earliest stages of mammalian pregnancy in a highly organized process known as neurulation. Environmental or genetic interferences can impair neurulation, resulting in clinically significant birth defects known collectively as neural tube defects. The Fuz gene encodes a subunit of the CPLANE complex, a macromolecular planar polarity effector required for ciliogenesis. Ablation of Fuz in mouse embryos results in exencephaly and spina bifida, including dysmorphic craniofacial structures due to defective cilia formation and impaired Sonic Hedgehog signaling.

Results: We demonstrate that knocking Fuz out during embryonic mouse development results in …

Neuroimaging Of The Effects Of Drug Exposure Or Self-Administration In Rodents: A Systematic Review, Gunner Drossel, Sarah R Heilbronner, Jan Zimmermann, Anna Zilverstand

Faculty, Staff and Students Publications

A systematic review of functional neuroimaging studies on drug (self-) administration in rodents is lacking. Here, we summarized effects of acute or chronic drug administration of various classes of drugs on brain function and determined consistency with human literature. We performed a systematic literature search and identified 125 studies on in vivo rodent resting-state functional magnetic resonance imaging (n = 84) or positron emission tomography (n = 41) spanning depressants (n = 27), opioids (n = 23), stimulants (n = 72), and cannabis (n = 3). Results primarily showed alterations in the striatum, consistent with the human literature. The anterior …

Targeting Calpain-2-Mediated Junctophilin-2 Cleavage Delays Heart Failure Progression Following Myocardial Infarction, Satadru K Lahiri, Jiao Lu, Yuriana Aguilar-Sanchez, Hui Li, Lucia M Moreira, Mohit M Hulsurkar, Arielys Mendoza, Mara R Turkieltaub Paredes, Jose Alberto Navarro-Garcia, Elda Munivez, Brooke Horist, Oliver M Moore, Gunnar Weninger, Sören Brandenburg, Christof Lenz, Stephan E Lehnart, Rana Sayeed, George Krasopoulos, Vivek Srivastava, Lilei Zhang, Jason M Karch, Svetlana Reilly, Xander H T Wehrens

Faculty, Staff and Students Publications

Coronary heart disease (CHD) is a prevalent cardiac disease that causes over 370,000 deaths annually in the USA. In CHD, occlusion of a coronary artery causes ischemia of the cardiac muscle, which results in myocardial infarction (MI). Junctophilin-2 (JPH2) is a membrane protein that ensures efficient calcium handling and proper excitation-contraction coupling. Studies have identified loss of JPH2 due to calpain-mediated proteolysis as a key pathogenic event in ischemia-induced heart failure (HF). Our findings show that calpain-2-mediated JPH2 cleavage yields increased levels of a C-terminal cleaved peptide (JPH2-CTP) in patients with ischemic cardiomyopathy and mice with experimental MI. We created …

A Systematic Review And Expert Delphi Consensus Recommendation On The Use Of Vaccines In Patients Receiving Dupilumab: A Position Paper Of The American College Of Allergy, Asthma And Immunology, Jay A Lieberman, Derek K Chu, Tasnuva Ahmed, Timothy E Dribin, Elissa M Abrams, Aikaterini Anagnostou, Kimberly G Blumenthal, Mark Boguniewicz, Nicole M Chase, David B K Golden, Nicholas L Hartog, Jennifer R Heimall, Tina Ho, Monica G Lawrence, David A Khan, Timothy Dean Minniear, S Shahzad Mustafa, John J Oppenheimer, Elizabeth J Phillips, Allison Ramsey, Nicholas L Rider, Lynda Schneider, Marcus S Shaker, Jonathan M Spergel, Cosby A Stone, David R Stukus, Julie Wang, Matthew J Greenhawt

Faculty, Staff and Students Publications

BACKGROUND: Dupilumab is a monoclonal antibody that targets the interleukin (IL)-4 receptor alpha subunit, thus blocking the effects of IL-4 and IL-13, and has shown efficacy in treating various conditions including asthma, atopic dermatitis, eosinophilic esophagitis, and others. Because of its immune modulatory effects, clinical trials that studied dupilumab did not allow patients to receive live vaccines during the clinical trials because of an abundance of caution, and thus package inserts recommend that patients who are being treated with dupilumab should avoid live vaccines. Because dupilumab is now approved for use in patients from 6 months of age for the …

Women’S Health And Kidney Protective Medications, Mythri Shankar, Sehrish Ali, Silvi Shah

Faculty, Staff and Students Publications

Purpose of review: We discuss the sex-based differences in the pharmacokinetics and pharmacodynamics of kidney protective medications and their implications on women's health.

Recent findings: A critical examination of adverse drug reactions highlights the underrepresentation of women in clinical trials for kidney and cardiovascular protective drugs, such as SGLT2 inhibitors, ACE inhibitors, and endothelin receptor antagonists. This underscores the need for sex-specific analyses in clinical studies to accurately assess medication efficacy and safety.

Summary: The research demonstrates that women are more likely to experience adverse events and less likely to benefit from certain treatments, emphasizing the urgent need for healthcare …