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Individual And Cultural Differences In Compassion, Noticing Suffering, And Well-Being: Consequences Of Wanting To Avoid Feeling Negative, Birgit Koopmann-Holm, Alexandra Beccari, Monet Oosthuizen

Psychology

Although people across the globe experience suffering, some individuals find it difficult to respond to others' distress because they might not know what would be most helpful to that person in that particular situation. For instance, would a response that focuses on the silver lining or one that acknowledges the suffering of the other person be more compassionate and helpful? In this paper, we demonstrate that the construct of avoided negative affect (ANA), the degree to which people want to avoid feeling negative, can predict individual differences and explain cultural variations in several aspects of compassion. Because ANA is a …

Anty 101h.03: Anthropology And The Human Experience, Erin D. Rosenkrance

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Chmy 123.H50: Introduction To Organic And Inorganic Chemistry, Julia Michelle Kotler

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Admixture Mapping Of Cognitive Function In Diverse Hispanic And Latino Adults: Results From The Hispanic Community Health Study/Study Of Latinos, Rui Xia, Xueqiu Jian, Amanda L Rodrigue, Jan Bressler, Eric Boerwinkle, Biqi Cui, Martha L Daviglus, Charles Decarli, Linda C Gallo, David C Glahn, Emma E M Knowles, Jee-Young Moon, Thomas H Mosley, Claudia L Satizabal, Tamar Sofer, Wassim Tarraf, Fernando Testai, John Blangero, Sudha Seshadri, Hector M González, Myriam Fornage

Faculty, Staff and Student Publications

INTRODUCTION: We conducted admixture mapping and fine-mapping analyses to identify ancestry-of-origin loci influencing cognitive abilities.

METHODS: We estimated the association of local ancestry intervals across the genome with five neurocognitive measures in 7140 diverse Hispanic and Latino adults (mean age 55 years). We prioritized genetic variants in associated loci and tested them for replication in four independent cohorts.

RESULTS: We identified nine local ancestry-associated regions for the five neurocognitive measures. There was strong biological support for the observed associations to cognitive function at all loci and there was statistical evidence of independent replication at 4q12, 9p22.1, and 13q12.13.

DISCUSSION: Our …

44ti/44sc Generator Development And Radiolabeling Optimization For Medical Applications, Christine E. Schmidt-Kennelty

Dissertations, Theses, and Capstone Projects

In recent years, there has been a growing interest in scandium-44 (⁴⁴Sc) for medical applications due to its favorable decay properties. With a relatively short half-life of 3.97 hours and high positron branching ratio of 94.3%, ⁴⁴Sc is an ideal candidate for positron emission tomography (PET) imaging. However, producing ⁴⁴Sc without an on-site cyclotron limits access, as its short half-life makes it impractical to ship to more remote locations.

To address this issue, ⁴⁴Ti/⁴⁴Sc generators have become a focal point of research, providing an onsite source of⁴⁴Sc. Despite their potential, current …

Design And Characterization Of De Novo Photoactivated Charge Separating Proteins, Paul M. Molinaro

Dissertations, Theses, and Capstone Projects

Light activate charge separation can provide high energy electrons for a variety of chemical processes. Reaction center proteins serve as a scaffold for small molecules that serve as “hopping” sites for electrons. Previous reaction center designs are four helix bundles that bind at minimum two metalloporphyrin’s: a zinc porphyrin serves as a light activated electron donor, mimicking chlorophyl, and a heme molecule serving as the acceptor. The efficiency of these designs is hampered by the enhanced relaxation of the singlet excited state of zinc porphyrin molecules due to spin-orbit coupling with the paramagnetic heme acceptor. The optimal design would contain …

From Stars To Moons: Investigating Stellar Rotations, Planetary Interactions, And Exoplanetary Prospects, Rosario Cecilio-Flores-Elie

Dissertations, Theses, and Capstone Projects

The thesis is divided into two key sections. The first chapter presents the results of analyzing TESS light curves for 99 targets within the Carina-Near moving group. By deriving rotational periods, this analysis supports stellar age estimation, contributing to the broader efforts of the Backyard Worlds: Planet 9 citizen project in determining age parameters for 89 newly identified systems, including ultracool dwarf companions. These findings enhance our understanding of stellar rotation and evolution, offering new insights into the development of secondary co-moving objects like brown dwarfs.

The second chapter investigates planet-moon interactions within our solar system by examining mass ratios, …

The Truth And Other Fictions: The Nuance Of Truth In Medieval Literature, Mark-Allan Donaldson

Dissertations, Theses, and Capstone Projects

This dissertation, “The Truth and Other Fictions,” is an exploration of the functional relationship between fiction and truth. It discusses truth as a type of nuanced information which may exist in a variety of forms (i.e., objective truth, narrative truth, emotional truth, cultural truth, etc.) and explores how these truths may be created or communicated through the medium of literature. The dissertation also explores how fiction, either narrative or structural, assists in said creation and communication of truth and in some cases is the necessary component to these processes. The Middle Ages and its literature provide the ideal staging ground …

Reviewing Inclusive Sex Education Curriculum: A Policy Analysis Of California’S Healthy Youth Act (2015), Patrick P. Buzzell

Dissertations, Theses, and Capstone Projects

This study presents a critical policy analysis of California's Assembly Bill 329 (AB 329) regarding inclusive sex education, coupled with a series of coding phases of relevant data. AB 329, enacted in 2015, mandates comprehensive sexual health education in California schools, aiming to address the needs of diverse student populations, including sexually minoritized youth. The critical policy analysis examines the language, implementation, and potential impact of AB 329, considering its effectiveness in promoting inclusive sex education and mitigating disparities in sexual health outcomes among students. Utilizing CPA, textual and contextual elements of data related to AB 329 are scrutinized to …

Advancing Affective Computing: Emotion Recognition And Tracking Across Diverse Contexts (Varied Environments), Shao Liu

Dissertations, Theses, and Capstone Projects

Affective Computing (AC) is an interdisciplinary field that recognizes, interprets, and processes human emotions. Emotions are complex, involving consciousness, physical sensations, and behavioral expressions, and are significant in various domains like mental health, human-computer interaction, and social security. Real-world applications of AC include monitoring drivers’ emotional states to improve road safety and understanding the emotions expressed by artists in visual arts. Traditional methods relying on facial expressions often fall short due to the nuanced nature of emotions, which vary across individuals, cultures, and contexts. Accurate AC systems require sophisticated, multimodal models to handle these variations and external factors like noise …

Resting-State Eeg Microstate Features For Major Depressive Disorder Classification, George M. V. Quinn

Dissertations, Theses, and Capstone Projects

Neuroimaging studies have revealed consistent abnormalities in functional connectivity within specific neural networks that may serve as biomarkers for major depressive disorder (MDD). It is important to find inexpensive, non-invasive techniques that target these biomarkers to make diagnosis easier and more objective. EEG microstates are quasi-stable potential topographies that are thought to reflect the quasi-stable network activity of the underlying neural generators. MDD has been shown to alter features of the four canonical EEG microstates (A, B, C, D) with some conflicting results. The most consistent network abnormalities in MDD are found in the anterior default mode network, and this …

Voltage Set Points For Sodium Channel Inactivation: Intrinsic And Modulatory Mechanisms, Akshay Sharma

Dissertations, Theses, and Capstone Projects

During an action potential, voltage-gated sodium channels (VGSC) control sodium ion flow into the cytoplasm of cells by using membrane voltage to alter channel conformation. These membrane proteins exhibit three main functional conformations: closed, open, and fast-inactivated, with transitions between these states dependent on membrane voltage and kinetics. The channels open within 1 millisecond and swiftly transition from open to fast-inactivated within 1-2 milliseconds following membrane depolarization. Subsequent membrane repolarization resets the channels to the closed state. Notably, even at mildly depolarized potentials that preclude channel opening, VGSCs can undergo transitions between the closed and inactivated states, known as closed-state …

"White Slaves Of California": Race, Religion, And The Railroad In Maria Amparo Ruiz De Burton's The Squatter And The Don, Katie Buonanno

Dissertations, Theses, and Capstone Projects

In The Squatter and the Don (1885), Maria Amparo Ruiz de Burton depicts the decline of the Alamars, a patrician Californio family, in the years after California was annexed by the United States. This thesis explores the different rhetorical maneuvers Ruiz de Burton makes to place the Californios in a broad, enfranchising Anglo-American national paradigm. The novel negotiates the messy, competing histories of Spanish, Mexican, and American colonialism, ultimately making the case for the enduring presence of Spanish missionization in the region, as well as the cultural assimilability of the Californio population. While the novel has frequently been read as …

Supporting Social Equity Through Informal Spaces On An Urban Campus, Eve B. Klein

Dissertations, Theses, and Capstone Projects

This dissertation focuses on applying research to design in the setting of higher education. Specifically, it explores the informal spaces outside the classroom at a predominantly Black college in an urban setting. The existing structural challenges facing college students are many, including issues related to financial resources, mental health/wellness, family responsibilities, psychosocial identity formation, and structural racism. These challenges were compounded by the events of the spring of 2020, when a heightened awareness of anti-Black racism, combined with the hardships of COVID-19, brought college campuses to a close and masses of people to the streets to protest the unjust killings …

Newly Synthesized Pyroglutamate Amide And Its Neuroprotective Effect Against Neurotoxicity Induced Cell Death In Alzheimer's Disease, Nourelhouda Joutey Elamrani

Dissertations, Theses, and Capstone Projects

The neurodegenerative disorder is an umbrella term for a range of conditions that affects the neurons in the human brain causing neuronal cell death. The common pathway is the excitotoxicity, a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity leading to the cell death. One of the most common neurodegenerative disorders is Alzheimer’s disease (AD), which represents 60 – 70% of cases and it ranked fourth cause of mortality in the USA. In Alzheimer’s disease, glutamate released from astrocytes and activates extrasynaptic N-methyl-D-aspartate …

Relationship Interventions For Autistic Children And Their Non-Autistic Siblings, Susan Vanessa Mchugh

Dissertations, Theses, and Capstone Projects

Relationships between children with autism and their non-autistic siblings are often characterized by great warmth, empathy, and affection. However, because of core deficits in social-emotional reciprocity, autistic children and their siblings often experience difficulties with communication, play, and associated mental health problems. Interventions aimed at improving relationships in these sibling dyads historically have involved teaching non-autistic children to behave similarly to interventionists for autistic siblings, and support groups for children with broad chronic illnesses. More recent interventions have shifted focus to improvement of play between siblings, and support groups for siblings of children with autism spectrum disorder. Some are naturalistic …

Self-Perceived Cognitive Functioning In Motoric Cognitive Risk Syndrome: Enhancing Risk Detection In Health Disparity Older Adults, Caroline O. Nester

Dissertations, Theses, and Capstone Projects

Motoric Cognitive Risk Syndrome (MCR) is a predementia condition that combines two clinical presentations associated with dementia: slow gait speed and subjective cognitive concerns (SCC). MCR diagnosis is associated with increased risk for dementia over its individual components of SCC or slow gait alone, making it a valuable marker of early neurodegenerative changes. MCR does not require expensive, time-consuming assessments to be diagnosed, broadening accessibility in remote or under-resourced settings. At present, there is no consistent method to assess SCC in MCR – a key diagnostic feature of the syndrome. The lack of understanding about SCC in MCR may limit …

Exploiting The Heavy Chain Glycans For The Improvement Of Radioimmunoconjugates, Cindy Rodriguez

Dissertations, Theses, and Capstone Projects

Radiolabeled antibodies have become indispensable tools in nuclear medicine. However, the natural roles of antibodies within the immune system mean that they have several intrinsic limitations as a platform for radiopharmaceuticals. A handful of recent preclinical studies suggest that binding by FcR and particularly FcyRI can affect the pharmacokinetic profiles of 89Zr-labeled radioimmunoconjugates. Fc receptors (FcR) are responsible for many of the interactions between immunoglobulins (IgG) and immune cells. In biomedicine, this interplay is critical to the activity of several types of immunotherapeutics; however, relatively little is known about how FcRs affect the in vivo performance of radiolabeled antibodies. Antibodies …

Imaging Markers Of Future Neurodegeneration Following Moderate-Severe Traumatic Brain Injury, Daniel Brennan

Dissertations, Theses, and Capstone Projects

The overall goal of this dissertation was to identify patterns of cerebral atrophy following traumatic brain injury and relate relevant imaging measures to that atrophy. In Chapter 2, we outline a spatiotemporal profile of atrophy in the first year following moderate-severe TBI: prior to 3-months post injury, the frontal and temporal cortices were observed to be thinner than controls, and thalamic volumes were reduced. From 3-12 months post-injury, significant atrophy was observed in white matter, subcortical gray matter structures (including thalamus), and cortical thinning was observed in the parietal and occipital cortices.

In Chapter 3, we identified widespread white matter …

Defining Resilience In Young People With Inflammatory Bowel Disease: A Theory Informed Approach, Barbara Storch

Dissertations, Theses, and Capstone Projects

Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal illness for which there is no existing cure. There is significant literature documenting the increased likelihood of adverse biopsychosocial outcomes in young people with IBD (e.g., Greenley et al., 2010); however, many individuals with IBD respond by either maintaining or increasing outcomes categorized as positive. These trajectories can be thought of as characterized by a resilient response. The study of resilience in young people with IBD is nascent. Given the unique disease-specific and developmental contexts young people with IBD experience, the first step in understanding the process of resilience in young people …

Investigating The Impact Of Affect In Suicide-Specific Attentional Biases, Beverlin Rosario-Williams

Dissertations, Theses, and Capstone Projects

Objective: Biased processing of suicide-related information has been implicated in risk of future suicidal thoughts and behaviors. Although previous studies have classified this biased processing, the tasks used to examine these biases cannot definitely specify which attentional processes are related to risk for suicidal thoughts and behaviors. Therefore, via two independent studies, this dissertation sought to distinguish suicide-specific attentional engagement and disengagement biases from other forms of cognitive processing, such as accessibility of suicide-related stimuli and threat bias toward and away from socially threatening stimuli. Additionally, this dissertation investigated under which affective conditions suicide-specific engagement and disengagement biases emerged. …

The Effects Of Mood And Anxiety Sensitivity On Attentional Engagement And Disengagement In Sleep Disturbance, Kara L. Buda

Dissertations, Theses, and Capstone Projects

Insomnia is a highly prevalent, chronic disorder that is associated with adverse psychological, physical, and psychosocial outcomes. Harvey’s (2002) cognitive model of insomnia and Espie’s (2006) attention-intention-effort pathway model highlight two critical processes believed to play a role in the onset and persistence of insomnia: (a) emotional distress and physiological arousal and (b) selective attention and monitoring. However, investigations examining attentional bias in sleep disturbance have produced mixed results and have exclusively used paradigms that are limited in their ability to differentially examine the two unique components of attentional bias (i.e., facilitated engagement, impaired disengagement). Discrepant findings in the attentional …

Autophagy And Meiotic Fidelity In C. Elegans, Kaitlin E. Kosinski

Dissertations, Theses, and Capstone Projects

Autophagy is an evolutionarily conserved multi-step recycling process in which cellular material is enclosed in the double membrane-bound autophagosome, which fuses with the lysosome to degrade its contents. Autophagy is essential for development and cellular adaptation to environmental or intracellular stress and is an important regulator of germline stem cell homeostasis in the model nematode C. elegans. We sought to determine if autophagy is important for genome stability during meiosis and found that the core adult C. elegans autophagy genes bec-1, atg-7, unc-51, and atg-18 were all required for proper meiotic development of oocytes. Loss of these …

The Influence Of Environmental Change On Genetic Diversity Across Spatial And Taxonomic Scales, Connor M. French

Dissertations, Theses, and Capstone Projects

The spatial distribution of genetic diversity is of interest to biodiversity scientists and conservationists and is a fundamental metric of biodiversity. Genetic diversity patterns across spatial and taxonomic scales contain information about population and assemblage dynamics that can convey their resilience to environmental change. Ectotherms are especially linked to their environments and may be especially sensitive to fluctuations in the environment over time. Herein, I investigate global and regional patterns of genetic diversity in two groups of ectotherms, insects and lizards, to understand the relationship between environmental change and genetic diversity, from populations to assemblages. Overall, my research aims to …

A Multilevel Approach To The Analysis And Visualization Of Timbral Brightness In Post-Tonal Music, Stephen Spencer

Dissertations, Theses, and Capstone Projects

This dissertation develops a method for the analysis and visualization of timbral brightness in post-tonal music. Brightness, a salient timbral attribute correlated with the prominence of high frequencies in the sound spectrum, is crucial for distinguishing sounds and discerning how they fit together in music. The dissertation employs a multilevel analytical approach, measuring differences in brightness at multiple “textural levels” and temporal scales. The analytical utility of the approach is demonstrated through four case studies, each one closely examining the score and audio of a piece of instrumental music written in the first quarter of the twentieth century.

Chapter …

Incorporating Solvation Thermodynamic Mapping In Computer-Aided Drug Design, Yeonji Ji

Dissertations, Theses, and Capstone Projects

Advancements in computational techniques have revolutionized structure-based drug design, substantially improving the efficiency and effectiveness of the drug discovery process by reducing time, costs, and labor requirements. These advancements include various methods, such as investigating small molecule ligands binding to proteins, exploring alternative protein conformations, and solvation mapping on the protein surfaces. Among these methods, understanding the correlation between protein-ligand binding and the role of solvation is important.

A fundamental concept in protein-ligand binding is shape and electrostatic complementarity, which is complicated by the inherent flexibility of proteins. In the absence of small molecule ligands, proteins are complementary to surface …

Unpacking Normative Change: The United Nations At Its 60th Anniversary, Giovanna Marques Kuele

Dissertations, Theses, and Capstone Projects

This dissertation explores the UN at its 60th anniversary at a critical juncture, with seven nested observations, to answer why normative change happens at the UN, when it is triggered, and which proposed changes are ultimately adopted. It argues that normative change at the UN is a result of multilevel political consensus at critical junctures. At the macro level, these junctures are triggered by global crises and international summits that provide a moment of normative reflection among the three UNs—member states, secretariat, and non-state actors—thereby increasing the likelihood of achieving multilevel political consensus. At the micro level, the formation of …

Perceptual Expectation, Rebecca Keller

Dissertations, Theses, and Capstone Projects

You are currently seeing many things, and, hopefully, you are currently about to see many other things. Many of the things that you are about to see will not be surprising, because you expect to see them. Sometimes, though, when you expect to see one thing and are faced with another, that thing will look like the thing you expected it to be, and not like the thing it actually is. This dissertation is an attempt to get a handle on what is happening in the visual system in these instances. In particular, I am trying to figure out what …

Loneliness And The Urban American (Non-)Romantic, Sarah C. Cook

Dissertations, Theses, and Capstone Projects

Loneliness, also known as ‘perceived social isolation,’ is an increasingly common feeling among Americans. It can be critically unhealthy when chronic, and recent revelations about its health effects have garnered a significant amount of media attention. Although statistical evidence tells us that marriage is the strongest defense against loneliness, over a third of Millennials and Gen-Zers say marriage is outdated; and census data shows that living alone is both one of the fastest-growing demographics in America, as well as a relatively stable housing arrangement. After examining existing research and media reports on loneliness itself in some depth, including factors that …

Repurposing Bt-11 To Treat Alzheimer’S Disease: Exploring The Glutathione-S-Transferase Lancl2 As A Target, Emily Birnbaum

Dissertations, Theses, and Capstone Projects

Approximately 99.6% of potential Alzheimer’s drugs fail, thus developing successful drugs is a high priority. The failure at developing successful drugs relates to the complex nature of the disease itself. Many components act together to trigger a cascade that ultimately results in neurodegeneration and cognitive dysfunction associated with the disease. In building a multiplex model of Alzheimer’s it is important to understand its specific biological mechanisms. One of these key pathological mechanisms is neuroinflammation. Understanding the pathways involved in neuroinflammation in Alzheimer’s is an urgent need, as it poses a promising avenue for future effective therapeutics. Specifically, as many investigational …