Digital Commons Network^™

A Marine Knowledge System For Ocean Affairs: Integrating Data, Evaluating Usage, And Enabling Sustainable Marine Management, Yu-Jen Pan

Journal of Marine Science and Technology–Taiwan

This study presents the evolution and assessment of the Marine Knowledge Education System (MKES), designed to improve user acceptance among students in professional marine science courses in Taiwan. The MKES leverages real-world maritime cases from the General Coast Guard Administration and is built upon existing technologies like cloud services, social networks, and data analysis tools. The technology acceptance model (TAM) provides the theoretical underpinning for the assessment of user confidence. Data was collected from 190 participants through purposive sampling. Path analysis confirmed all hypothesized relationships within the TAM with statistical significance (p < 0.001). Additionally, paired-sample t-tests revealed a significant increase in student acceptance of the MKES after integrating it into the marine science curriculum. These findings underscore the capacity of the MKES as a digital learning tool to enrich course pedagogy and improve student learning outcomes, thereby offering valuable support in advancing the education of professional marine managers.

Embodiment, Plasticity, And The Re/Production Of Gender, Sex, And Race In Human Biology, Meredith Wilson

Human Biology Open Access Pre-Prints

This paper historically situates human biology research by engaging with feminist science and technology scholars to show how a key mechanism of embodiment, plasticity, is used to re/produce sex and gender binaries in anthropological research and beyond. I begin by defining embodiment and demonstrating its reliance on plasticity. Next, I discuss plasticity and review how and why it has been taken up in human biology research. After, I engage with the works of feminist, trans, and queer scholars who have examined the connection between embodiment, plasticity, and the creation of Western binarized sex and gender. Further, I present how the …

Evidence And Mechanisms Of Embodiment In The Developing Dentition, Valerie Sgheiza

Human Biology Open Access Pre-Prints

Existing research supports both embodiment of stress through epigenetics and epigenetic impacts on dental development. Two models for embodiment of stress in dental development are proposed. Stress-delay proposes that increased stress during development will produce delays in dental development. Inflammation-acceleration proposes that increased stress will produce faster dental development through inflammatory pathways. These models were tested on dental development scores from the New Mexico Decedent Image Database by using non-accidental manner of death (homicide, suicide, and natural) as a proxy for elevated stress exposure during life and cadaver BMI percentile as a proxy for living BMI. Sex was treated as …

Spartan Daily, September 4, 2024, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2024

Volume 163, Issue 5

A Spectrum Of Violence: The Intersection Of Antemortem And Postmortem Embodiment In Migrant Death Investigation At The U.S.-Mexico Border, Molly A. Kaplan, Caroline Znachko

Human Biology Open Access Pre-Prints

The objective of the present literature review is to examine how the humanitarian crisis of migrant death at the U.S.-Mexico border epitomizes the antemortem and postmortem dimensions of structural violence and the lasting effects it can have on the human body. After describing the ongoing migrant death crisis, we review embodiment constructs in biological anthropology pertaining to structural violence and marginalization across the life course. We then survey studies examining skeletal and dental biomarkers of structural violence as embodied in migrant populations, including oral pathology, dental modifications, porotic hyperostosis, cribra orbitalia, enamel hypoplasia, cranial fluctuating asymmetry, vertebral neural canal size, …

Environmental Sensitivity Index (Esi) Feasibility Study Of All-Hazards Indices Expansion, Research Planning, Inc

Coastal Response Research Center

Environmental Sensitivity Index (ESI) products are developed by the National Oceanic and Atmospheric Administration (NOAA) to support planning for and responding to coastal oil and chemical spills. ESI data describe a variety of coastal resources that are at risk from oil spills that include sensitive shorelines (e.g., marshes, tidal flats), biological resources (e.g., birds, shellfish beds), and human-use resources (e.g., public beaches, water intakes). ESI maps and datasets include shoreline types that are ranked according to their sensitivity to oil and chemical spills. This index was the original focus of ESI maps and has been a standard for industry and …

Commonwealth Times 2024-09-04

Commonwealth Times, 1969-

No abstract provided.

The Foodpunk City: Advancing Portland's Food Security Through A Shared Ideology Of Adaptation & Resistance, Nickolas Hash

Dissertations and Theses

Food injustice is a form of violence perpetrated by state and corporate actors against a constituency under their governing power, particularly impacting marginalized and impoverished communities. It denies individuals access to nutritious food, perpetuating cycles of poverty, inequality, physical health risks, and social exclusion. Grassroots movements have emerged to challenge dominant paradigms and advocate for food sovereignty, agroecology, and food anarchy. In Portland, the movement represents a nontraditional approach to food security that closely resembles the reactionary ideology of urban "punk" culture. Both groups prioritize community autonomy over food systems, sustainable agricultural practices, and resistance to oppressive structures that perpetuate …

September 4, 2024 General Faculty Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

September 4, 2024 Blazer Weekly, University Of Alabama At Birmingham

Blazer Weekly (student newsletter)

No abstract provided.

Perspectives In Embodiment Theory, Sana Saboowala, Maria Cox

Human Biology Open Access Pre-Prints

Researchers apply the concept of embodiment across many disciplines, resulting in a set of expansive definitions that only sometimes overlap. This special issue celebrates the plurality and wide applicability of this useful framework by bringing together multiple perspectives on embodiment within the field of human biology.

September 4, 2024, Faculty, Illinois Wesleyan University

2024-2025

No abstract provided.

Embodiment In Anthropological Epigenetics Research, Sana Saboowala, Meredith A. Wilson, Sahara Z. Vilchis, Mary P. Rogers-Lavanne

Human Biology Open Access Pre-Prints

This paper reviews literature in human epigenetic research as a case study in order to examine and critique the dominant framework of embodiment as unidirectional or bidirectional and mechanistically driven. We identify three major critiques to this approach: 1) A treatment of epigenetic traits as a mechanism of embodiment, rather than one of the multidirectional components of the dynamic and ongoing embodiment process; 2) A tendency to view changing epigenetic traits as both the cause and solution for embodied social inequalities rather than examining the need for systemic change; and 3) A loss of the complexity of varied lived experiences …

Chem 244a-003: Organic Chemistry Lab, Hussain Mustansar

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

The Endoplasmic Reticulum As An Active Liquid Network, Laura M. Westrate, Zubenelgenubi C. Scott, Samuel B. Steen, Greg Huber, Elena F. Koslover

University Faculty Publications and Creative Works

The peripheral endoplasmic reticulum (ER) forms a dense, interconnected, and constantly evolving network of membrane-bound tubules in eukaryotic cells. While individual structural elements and the morphogens that stabilize them have been described, a quantitative understanding of the dynamic large-scale network topology remains elusive. We develop a physical model of the ER as an active liquid network, governed by a balance of tension-driven shrinking and new tubule growth. This minimalist model gives rise to steady-state network structures with density and rearrangement timescales predicted from the junction mobility and tubule spawning rate. Several parameter-independent geometric features of the liquid network model are …

Single-Cell And Spatial Proteo-Transcriptomic Profiling Reveals Immune Infiltration Heterogeneity Associated With Neuroendocrine Features In Small Cell Lung Cancer, Ying Jin, Yuefeng Wu, Alexandre Reuben, Liang Zhu, Carl M Gay, Qingzhe Wu, Xintong Zhou, Haomin Mo, Qi Zheng, Junyu Ren, Zhaoyuan Fang, Teng Peng, Nan Wang, Liang Ma, Yun Fan, Hai Song, Jianjun Zhang, Ming Chen

Faculty, Staff and Student Publications

Small cell lung cancer (SCLC) is an aggressive pulmonary neuroendocrine malignancy featured by cold tumor immune microenvironment (TIME), limited benefit from immunotherapy, and poor survival. The spatial heterogeneity of TIME significantly associated with anti-tumor immunity has not been systemically studied in SCLC. We performed ultra-high-plex Digital Spatial Profiling on 132 tissue microarray cores from 44 treatment-naive limited-stage SCLC tumors. Incorporating single-cell RNA-sequencing data from a local cohort and published SCLC data, we established a spatial proteo-transcriptomic landscape covering over 18,000 genes and 60 key immuno-oncology proteins that participate in signaling pathways affecting tumorigenesis, immune regulation, and cancer metabolism across 3 …

Screening Of Anti-Prion Compounds Using The Protein Misfolding Cyclic Amplification Technology, Sandra Pritzkow, Isaac Schauer, Ananya Tupaki-Sreepurna, Rodrigo Morales, Claudio Soto

Faculty, Staff and Student Publications

Prion diseases are 100% fatal infectious neurodegenerative diseases affecting the brains of humans and other mammals. The disease is caused by the formation and replication of prions, composed exclusively of the misfolded prion protein (PrPSc). We invented and developed the protein misfolding cyclic amplification (PMCA) technology for in vitro prion replication, which allow us to replicate the infectious agent and it is commonly used for ultra-sensitive prion detection in biological fluids, tissues and environmental samples. In this article, we studied whether PMCA can be used to screen for chemical compounds that block prion replication. A small set of compounds previously …

Myc Induces Oncogenic Stress Through Rna Decay And Ribonucleotide Catabolism In Breast Cancer, Jitendra K Meena, Jarey H Wang, Nicholas J Neill, Dianne Keough, Nagireddy Putluri, Panagiotis Katsonis, Amanda M Koire, Hyemin Lee, Elizabeth A Bowling, Siddhartha Tyagi, Mayra Orellana, Rocio Dominguez-Vidaña, Heyuan Li, Kenneth Eagle, Charles Danan, Hsiang-Ching Chung, Andrew D Yang, William Wu, Sarah J Kurley, Brian M Ho, Joseph R Zoeller, Calla M Olson, Kristen L Meerbrey, Olivier Lichtarge, Arun Sreekumar, Clifford C Dacso, Luke W Guddat, Dominik Rejman, Dana Hocková, Zlatko Janeba, Lukas M Simon, Charles Y Lin, Monica C Pillon, Thomas F Westbrook

Faculty, Staff and Students Publications

Upregulation of MYC is a hallmark of cancer, wherein MYC drives oncogenic gene expression and elevates total RNA synthesis across cancer cell transcriptomes. Although this transcriptional anabolism fuels cancer growth and survival, the consequences and metabolic stresses induced by excess cellular RNA are poorly understood. Herein, we discover that RNA degradation and downstream ribonucleotide catabolism is a novel mechanism of MYC-induced cancer cell death. Combining genetics and metabolomics, we find that MYC increases RNA decay through the cytoplasmic exosome, resulting in the accumulation of cytotoxic RNA catabolites and reactive oxygen species. Notably, tumor-derived exosome mutations abrogate MYC-induced cell death, suggesting …

Intracellular Islatravir-Triphosphate Half-Life Supports Extended Dosing Intervals, Xiaowei Zang, Wendy Ankrom, Walter K. Kraft, Ryan Vargo, S Aubrey Stoch, Marian Iwamoto, Randolph P Matthews

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Antiretroviral therapy has substantially reduced morbidity, mortality, and disease transmission in people living with HIV. Islatravir is a nucleoside reverse transcriptase translocation inhibitor that inhibits HIV-1 replication by multiple mechanisms of action, and it is in development for the treatment of HIV-1 infection. In preclinical and clinical studies, islatravir had a long half-life (t½) of 3.0 and 8.7 days (72 and 209 hours, respectively); therefore, islatravir is being investigated as a long-acting oral antiretroviral agent. A study was conducted to definitively elucidate the terminal t½ of islatravir and its active form islatravir-triphosphate (islatravir-TP). A single-site, open-label, non-randomized, single-dose phase 1 …

Molecularly Imprinted Wearable Sensor With Paper Microfluidics For Real-Time Sweat Biomarker Analysis, Mayank Garg, Heng Guo, Ethan Maclam, Elizabeth Zhanov, Sathwika Samudrala, Anton Pavlov, Md Saifur Rahman, Myeong Namkoong, Jennette P Moreno, Limei Tian

Faculty, Staff and Student Publications

The urgent need for real-time and noninvasive monitoring of health-associated biochemical parameters has motivated the development of wearable sweat sensors. Existing electrochemical sensors show promise in real-time analysis of various chemical biomarkers. These sensors often rely on labels and redox probes to generate and amplify the signals for the detection and quantification of analytes with limited sensitivity. In this study, we introduce a molecularly imprinted polymer (MIP)-based biochemical sensor to quantify a molecular biomarker in sweat using electrochemical impedance spectroscopy, which eliminates the need for labels or redox probes. The molecularly imprinted biosensor can achieve sensitive and specific detection of …

A Revision Of Hong Kong Harvestmen : Biodiversity, Ecological Preferences And Geographical Distribution, Kai Teck Desmond Tan

Lingnan Theses (MPhil & PhD)

Opiliones, or harvestmen, is a common animal found throughout the world, there are currently over 6,650 species worldwide but the actual number is estimated to exceed 10,000, making it the third largest order in the class Arachnida. Despite its diversity, it is a rather understudied group. In Hong Kong, there are four described species, but the most recent relevant literature dates back to the at least the early 20th century. This thesis focuses on two common species found in Hong Kong: one previously described species (Heterobiantes geniculatus) and one new species (Pseudoleiobunum lutulentum sp. nov.). I …

Post-Wildfire Water Quality Dynamics: A Multiscale Examination And Predictive Modeling Of Stream Temperature And Turbidity In Western U.S. Watersheds, Junjie Chen

Dissertations and Theses

Wildfires, exacerbated by climate change and human activities, pose significant threats to water-related ecosystem services in forested watersheds. This dissertation investigates the multifaceted impacts of wildfires on stream temperature and turbidity, two critical water quality parameters essential for maintaining aquatic ecosystem health and human water uses. By integrating a comprehensive literature review, empirical data analysis, and advanced machine learning techniques, this research provides a nuanced understanding of how wildfires affect hydrological processes across various temporal and spatial scales.

The findings reveal significant regional variability and the complex interplay between climatic, geographic, and anthropogenic factors. For instance, the literature review highlights …

The Prognostic Effect Of Infiltrating Immune Cells Is Shaped By Proximal M2 Macrophages In Lung Adenocarcinoma, Jian-Rong Li, Vikram Shaw, Yupei Lin, Xiang Wang, Muhammad Aminu, Yong Li, Jia Wu, Jianjun Zhang, Christopher I Amos, Chao Cheng

Faculty, Staff and Students Publications

The spatial arrangement of immune cells within the tumor microenvironment (TME) and their interactions play critical roles in the initiation and development of cancer. Several advanced technologies such as imaging mass cytometry (IMC) providing the immunological landscape of the TME with single-cell resolution. In this study, we develop a new method to quantify the spatial proximity between different cell types based on single-cell spatial data. Using this method on IMC data from 416 lung adenocarcinoma patients, we show that the proximity between different cell types is more correlated with patient prognosis compared to the traditional features such immune cell density …

G Protein Selectivity Profile Of Gpr56/Adgrg1 And Its Effect On Downstream Effectors, Raida Jallouli, Ana L Moreno-Salinas, Andréanne Laniel, Brian Holleran, Charlotte Avet, Joan Jacob, Trang Hoang, Christine Lavoie, Kendra S Carmon, Michel Bouvier, Richard Leduc

Faculty, Staff and Student Publications

GPR56, an adhesion G-protein coupled receptor (aGPCRs) with constitutive and ligand-promoted activity, is involved in many physiological and pathological processes. Whether the receptor's constitutive or ligand-promoted activation occur through the same molecular mechanism, and whether different activation modes lead to functional selectivity between G proteins is unknown. Here we show that GPR56 constitutively activates both G12 and G13. Unlike constitutive activation and activation with 3-α-acetoxydihydrodeoxygedunin (3αDOG), stimulation with an antibody, 10C7, directed against GPR56's extracellular domain (ECD) led to an activation that favors G13 over G12. An autoproteolytically deficient mutant, GPR56-T383A, was also activated by 10C7 indicating that the tethered …

Interannual Homing To Reproductive Sites And Transboundary Migration In Black Seabream Spondyliosoma Cantharus, With Implications For Management, Peter Davies, Thomas Stamp, Alice Hall, Allison Atterborne, Jen Lewis, George P Balchin, Alice Tebb, Sarah Ward, Francis Binney, Samantha Blampied, Alexander Plaster, Charlie Hubbard, Nick Rogers, Matthew Wiseman, Ronan Conlon, Shion E A Reynell, Emma V Sheehan

School of Biological and Marine Sciences

Fish spawning aggregations are vulnerable to overexploitation, which can have severe ecological, social, and economic consequences. Knowledge on the spatial ecology of aggregating species is often lacking, but is crucial for their effective conservation. This study explores the spawning site residency, interannual fidelity, and migration of black seabream Spondyliosoma cantharus using acoustic (n = 55) and conventional (n = 2397) tagging within and outside Marine Conservation Zones in the southern UK. Detections and recaptures of tagged fish indicated that black seabream display significant interannual fidelity to nesting areas, but that residency of individuals at nesting areas was short relative to …

Caring For Adolescent Learners In The Virtual Classroom: Lessons From The Covid-19 Pandemic, Stephanie Welch, Jeasik Cho

The Qualitative Report

In the recent past, fully online instruction has been most prominent at the higher education level, though online K-12 schools have lately gained some traction. However, the COVID-19 pandemic precipitated new potential for rapid expansion of online K-12 education. As these settings continue to develop, the unique social emotional needs of adolescent learners must be considered, and the need for a robustly developed online pedagogy of care is pressing. An unexpected and untapped resource for developing a framework for an online pedagogy of care can be found in examining the practices of traditionally face-to-face teachers who were unexpectedly thrust into …

Preexisting Skin-Resident Cd8 And Γδ T-Cell Circuits Mediate Immune Response In Merkel Cell Carcinoma And Predict Immunotherapy Efficacy, Zachary Z Reinstein, Yue Zhang, Oscar E Ospina, Matt D Nichols, Victoria A Chu, Alvaro De Mingo Pulido, Karol Prieto, Jonathan V Nguyen, Rui Yin, Carlos Moran Segura, Ahmed Usman, Brittney Sell, Spencer Ng, Janis V De La Iglesia, Sunandana Chandra, Jeffrey A Sosman, Raymond J Cho, Jeffrey B Cheng, Ellie Ivanova, Sergei B Koralov, Robbert J C Slebos, Christine H Chung, Nikhil I Khushalani, Jane L Messina, Amod A Sarnaik, Jonathan S Zager, Vernon K Sondak, Charles Vaske, Sungjune Kim, Andrew S Brohl, Xinlei Mi, Brian G Pierce, Xuefeng Wang, Brooke L Fridley, Kenneth Y Tsai, Jaehyuk Choi

Staff and Researcher Publications

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer with a ~50% response rate to immune checkpoint blockade (ICB) therapy. To identify predictive biomarkers, we integrated bulk and single-cell RNA-seq with spatial transcriptomics from a cohort of 186 samples from 116 patients, including bulk RNA-seq from 14 matched pairs pre- and post-ICB. In non-responders, tumors show evidence of increased tumor proliferation, neuronal stem cell markers, and IL-1. Responders have increased type I/II interferons and pre-existing tissue resident (Trm) CD8 or Vδ1 γδ T cells that functionally converge with overlapping antigen-specific transcriptional programs and clonal expansion of public TCRs. Spatial …

A Red Teaming Framework For Securing Ai In Maritime Autonomous Systems, Mathew J. Walter, Aaron Barrett, Kimberly Tam

School of Engineering, Computing and Mathematics

Artificial intelligence (AI) is being ubiquitously adopted to automate processes in science and industry. However, due to its often intricate and opaque nature, AI has been shown to possess inherent vulnerabilities which can be maliciously exploited with adversarial AI, potentially putting AI users and developers at both cyber and physical risk. In addition, there is insufficient comprehension of the real-world effects of adversarial AI and an inadequacy of AI security examinations; therefore, the growing threat landscape is unknown for many AI solutions. To mitigate this issue, we propose one of the first red team frameworks for evaluating the AI security …

A Genetic Screen In Drosophila Uncovers A Role For Senseless-2 In Surface Glia In The Peripheral Nervous System To Regulate Cns Morphology, Haluk Lacin, Yuqing Zhu, Jose T Dipaola, Beth A Wilson, Yi Zhu, James B Skeath

2020-Current year OA Pubs

Despite increasing in mass approximately 100-fold during larval life, the Drosophila CNS maintains its characteristic form. Dynamic interactions between the overlying basement membrane and underlying surface glia are known to regulate CNS structure in Drosophila, but the genes and pathways that establish and maintain CNS morphology during development remain poorly characterized. To identify genes that regulate CNS shape in Drosophila, we conducted an EMS-based, forward genetic screen of the second chromosome, uncovered 50 mutations that disrupt CNS structure, and mapped these alleles to 17 genes. Analysis of whole genome sequencing data wedded to genetic studies uncovered the affected gene for …

Prospects And Challenges Of Tissue-Derived Extracellular Vesicles, Justin C Lee, Roslyn M Ray, Tristan A Scott

Faculty, Staff and Students Publications

Extracellular vesicles (EVs) are considered a vital component of cell-to-cell communication and represent a new frontier in diagnostics and a means to identify pathways for therapeutic intervention. Recently, studies have revealed the importance of tissue-derived EVs (Ti-EVs), which are EVs present in the interstitial spaces between cells, as they better represent the underlying physiology of complex, multicellular tissue microenvironments in biology and disease. EVs are native, lipid bilayer membraned nano-sized particles produced by all cells that are packaged with varied functional biomolecules including proteins, lipids, and nucleic acids. They are implicated in short- and long-range cellular communication and may elicit …