Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 64261 - 64290 of 818397

Full-Text Articles in Entire DC Network

Substitution Of A Single Non-Coding Nucleotide Upstream Of Tmem216 Causes Non-Syndromic Retinitis Pigmentosa And Is Associated With Reduced Tmem216 Expression, Samantha Malka, Pooja Biswas, Anne-Marie Berry, Riccardo Sangermano, Mukhtar Ullah, Siying Lin, Matteo D'Antonio, Aleksandr Jestin, Xiaodong Jiao, Mathieu Quinodoz, Lori Sullivan, Jessica C Gardner, Emily M Place, Michel Michaelides, Karolina Kaminska, Omar A Mahroo, Elena Schiff, Genevieve Wright, Francesca Cancellieri, Veronika Vaclavik, Cristina Santos, Atta Ur Rehman, Sudeep Mehrotra, Hafiz Muhammad Azhar Baig, Muhammad Iqbal, Muhammad Ansar, Luisa Coutinho Santos, Ana Berta Sousa, Viet H Tran, Hiroko Matsui, Anjana Bhatia, Muhammad Asif Naeem, Shehla J Akram, Javed Akram, Sheikh Riazuddin, Carmen Ayuso, Eric A Pierce, Alison J Hardcastle, S Amer Riazuddin, Kelly A Frazer, J Fielding Hejtmancik, Carlo Rivolta, Kinga M Bujakowska, Gavin Arno, Andrew R Webster, Radha Ayyagari Sep 2024

Substitution Of A Single Non-Coding Nucleotide Upstream Of Tmem216 Causes Non-Syndromic Retinitis Pigmentosa And Is Associated With Reduced Tmem216 Expression, Samantha Malka, Pooja Biswas, Anne-Marie Berry, Riccardo Sangermano, Mukhtar Ullah, Siying Lin, Matteo D'Antonio, Aleksandr Jestin, Xiaodong Jiao, Mathieu Quinodoz, Lori Sullivan, Jessica C Gardner, Emily M Place, Michel Michaelides, Karolina Kaminska, Omar A Mahroo, Elena Schiff, Genevieve Wright, Francesca Cancellieri, Veronika Vaclavik, Cristina Santos, Atta Ur Rehman, Sudeep Mehrotra, Hafiz Muhammad Azhar Baig, Muhammad Iqbal, Muhammad Ansar, Luisa Coutinho Santos, Ana Berta Sousa, Viet H Tran, Hiroko Matsui, Anjana Bhatia, Muhammad Asif Naeem, Shehla J Akram, Javed Akram, Sheikh Riazuddin, Carmen Ayuso, Eric A Pierce, Alison J Hardcastle, S Amer Riazuddin, Kelly A Frazer, J Fielding Hejtmancik, Carlo Rivolta, Kinga M Bujakowska, Gavin Arno, Andrew R Webster, Radha Ayyagari

Faculty, Staff and Student Publications

Genome analysis of individuals affected by retinitis pigmentosa (RP) identified two rare nucleotide substitutions at the same genomic location on chromosome 11 (g.61392563 [GRCh38]), 69 base pairs upstream of the start codon of the ciliopathy gene TMEM216 (c.-69G>A, c.-69G>T [GenBank: NM_001173991.3]), in individuals of South Asian and African ancestry, respectively. Genotypes included 71 homozygotes and 3 mixed heterozygotes in trans with a predicted loss-of-function allele. Haplotype analysis showed single-nucleotide variants (SNVs) common across families, suggesting ancestral alleles within the two distinct ethnic populations. Clinical phenotype analysis of 62 available individuals from 49 families indicated a similar clinical presentation …

Go to article

Improving Ligand Pharmacokinetics Via Bioisosteric Substitution Of Amides With 1, 2, 3-Triazoles While Maintaining Dopamine D4 Receptor Selectivity And Potency, Mohammad Alkhatib Sep 2024

Improving Ligand Pharmacokinetics Via Bioisosteric Substitution Of Amides With 1, 2, 3-Triazoles While Maintaining Dopamine D4 Receptor Selectivity And Potency, Mohammad Alkhatib

Theses and Dissertations

Several neurophysiological functions, such as attention, cognition, and emotional regulation, are regulated by the binding of dopamine on G-Protein coupled receptors. D4Rs are mainly located in the prefrontal cortex and the hippocampus and are known to have a key role in decision-making, memory formation, cognition, and attention. Administration of D4Rs- selective ligands during the preclinical studies enhance the outcomes and the results in animal models suffering from neuropsychiatric disorders, including ADHD, substance use disorders (SUD), and Alzheimer's disease. Recently, we reported a group of D4R-selective ligands with different efficacies depending on their phenylpiperazine ring scaffold to illustrate D4R function during …

Go to article

Current Diagnostic And Quantitative Techniques In The Field Of Lymphedema Management: A Critical Review, Mary Vargo, Melissa Aldrich, Paula Donahue, Emily Iker, Louise Koelmeyer, Rachelle Crescenzi, Andrea Cheville Sep 2024

Current Diagnostic And Quantitative Techniques In The Field Of Lymphedema Management: A Critical Review, Mary Vargo, Melissa Aldrich, Paula Donahue, Emily Iker, Louise Koelmeyer, Rachelle Crescenzi, Andrea Cheville

The Brown Foundation: Institute of Molecular Medicine

Lymphedema evaluation entails multifaceted considerations for which options continue to evolve and emerge. This paper provides a critical review of the current status of diagnostic and quantitative measures for lymphedema, from traditional and novel bedside assessment tools for volumetric and fluid assessment, to advanced imaging modalities. Modalities are contrasted with regard to empirical support and feasibility of clinical implementation. The manuscript proposes a grid framework for comparing the ability of each modality to quantify specific lymphedema characteristics, including distribution, dysmorphism, tissue composition and fluid content, lymphatic anatomy and function, metaplasia, clinical symptoms, and quality of life and function. This review …

Go to article

Interoception In Pregnancy: Implications For Peripartum Depression, Paul W. Savoca, Laura M. Glynn, Molly M. Fox, Misty C. Richards, Bridget L. Callaghan Sep 2024

Interoception In Pregnancy: Implications For Peripartum Depression, Paul W. Savoca, Laura M. Glynn, Molly M. Fox, Misty C. Richards, Bridget L. Callaghan

Psychology Faculty Articles and Research

"In this perspective piece, we propose a novel mechanistic framework for peripartum depression in which improved interoceptive functioning in pregnancy and postpartum typically protects against depressive symptoms, but when there is a failure to improve interoception, the result is an inability to maintain metabolic efficiency, which ultimately poses risk for depression. First, we will review an emerging theory that links the modeling and predictive regulation of metabolic resources as central to the expression of many depressive symptoms. Then, focusing on the period of pregnancy to articulate the framework, we will discuss the physiological changes induced by pregnancy that place an …

Go to article

Strategies Cybersecurity Professionals Use To Mitigate Cybersecurity Threats In Small Businesses, Michael Bert Branham Sep 2024

Strategies Cybersecurity Professionals Use To Mitigate Cybersecurity Threats In Small Businesses, Michael Bert Branham

Walden Dissertations and Doctoral Studies

Small business owners are concerned about incorporating security best practices, security frameworks, and critical business functions into a cybersecurity strategy, which is necessary to adapt to the increased sophistication and occurrence of cyber-attacks. Grounded in Von Bertalanffy’s general system theory, the purpose of this qualitative pragmatic study was to explore strategies cybersecurity professionals use to mitigate cybersecurity threats in small businesses. A sample of 14 security professionals on LinkedIn shared their perspectives on how cybersecurity strategies successfully mitigated recent cybersecurity threats. Data were collected through semi-structured interviews, and data analysis was performed by coding keywords, phrases, and methods. The following …

Go to article

Homeless Individuals’ Experiences Of Access To Personal Hygiene And Sanitary Products And Processes During Menstruation, Chele Taylor-Jennifer Sep 2024

Homeless Individuals’ Experiences Of Access To Personal Hygiene And Sanitary Products And Processes During Menstruation, Chele Taylor-Jennifer

Walden Dissertations and Doctoral Studies

Homelessness and period (menstruation) poverty are recurring global phenomena. In the United States, approximately 220,000 women experience homelessness annually. Studies have shown that approximately 35% of individuals who menstruate experience period poverty while living in Baltimore, Maryland. The theoretical foundation was Wollstonecraft‘s theory of feminism. To better understand this phenomenon, a general qualitative study was conducted using semistructured interviews with 18 people who were once homeless while menstruating. Through data collection and analysis, five themes emerged: (a) women have had to find creative ways of addressing menstruation; (b) women have had to find creative ways of addressing the personal hygiene …

Go to article

Relationship Between Employee Trust And Intrinsic Motivation And Employee Turnover Intention, Frank W. Collige Sep 2024

Relationship Between Employee Trust And Intrinsic Motivation And Employee Turnover Intention, Frank W. Collige

Walden Dissertations and Doctoral Studies

Mental health managers are concerned with turnover because it affects employees, mental health programs, and patients. Drawing upon self-determination theory, the purpose of this quantitative correlational study was to determine if employee trust in leadership and intrinsic motivation were correlated to and, thus, predict turnover intention within the mental health field in Northeast Florida. Data were collected from 100 current mental health managers in middle management and below in Northeast Florida through psychologically valid questionnaires. The results of the stepwise multiple linear regression were not significant. A key recommendation is for managers to prioritize employee well-being for organizations in the …

Go to article

Enhancing Human Well-Being Through Cognitive And Affective Pathways Linking Landscape Sensation To Cultural Ecosystem Services, Yashi Wu, Lina Tang, Chang‑Bing Huang, Guofan Shao, Jundong Hou, Clive E. Sabel Sep 2024

Enhancing Human Well-Being Through Cognitive And Affective Pathways Linking Landscape Sensation To Cultural Ecosystem Services, Yashi Wu, Lina Tang, Chang‑Bing Huang, Guofan Shao, Jundong Hou, Clive E. Sabel

School of Geography, Earth and Environmental Sciences

Context: Landscape sensation is essential for the delivery of cultural ecosystem services (CESs), yet the pathways through which these services are delivered remain inadequately understood. Exploring how people obtain CESs from landscapes facilitates better understanding of the tradeoffs and synergies between ecosystem services and landscape sustainability. Objectives: This study aimed to elucidate the sensory pathways that links landscape attributes to CESs, focusing on the roles of cognitive and affective experiences. Methods: We analyzed social media comments for the measurement scale of cognition. We employed partial least squares structural equation modeling to integrate sensation, cognition, affect, and satisfaction, using questionnaire data …

Go to article

Racialization’S Influence On African American Male University Attrition: Is It Culture Shock Or Is There More To The Story, Joseph M. Butler Sep 2024

Racialization’S Influence On African American Male University Attrition: Is It Culture Shock Or Is There More To The Story, Joseph M. Butler

Dissertations

This dissertation investigates the influence of racialization on the attrition rates of African American male students in predominantly white institutions (PWIs). The study examines whether these students experience cultural shock or face more profound systemic challenges. The research explores how African American men navigate and perceive their college environments by employing Critical Race Theory and DuBois' double consciousness. The research utilizes a mixed-methods approach, combining qualitative interviews, demographic surveys, and document analysis to view these students' experiences comprehensively. The study focuses on four religiously affiliated universities, highlighting the intersection of race, identity, and institutional culture and revealing patterns of isolation, …

Go to article

Clinical Social Workers, Telemental Health And The Covid-19 Pandemic, Juli Chaffee Sep 2024

Clinical Social Workers, Telemental Health And The Covid-19 Pandemic, Juli Chaffee

Dissertations

As a result of the COVID-19 Pandemic, and due to the shelter in place order that most states required, licensed clinical social workers (CSW’s) were forced to switch from in person services to telemental health services almost overnight. Many did so without previous training, adequate technology, a confidential office, or professional support. While there is a growing body of research regarding the increased use of telemental health in the mental health field during COVID-19, there is minimal research which narrows in what it was like for the CSW’s who made this transition. The purpose of this study was to better …

Go to article

Impacts Of Stormwater And Land Cover On The Abundance, Transport, And Composition Of Anthropogenic Litter In Urban Watersheds, Bailey Austin Schwenk Sep 2024

Impacts Of Stormwater And Land Cover On The Abundance, Transport, And Composition Of Anthropogenic Litter In Urban Watersheds, Bailey Austin Schwenk

Master's Theses

Anthropogenic litter (AL; trash) is defined as any manufactured item that ends up in the environment. AL consists of many different materials including glass, metal, and plastic, the latter of which typically represents a dominant constituent and has been a major focus of research. Plastic litter and other AL types are pervasive to all types of ecosystems, are persistent in the environment, and are increasing. Rivers are a major conduit transporting AL to oceans. However, rivers also retain and transform AL. More research is needed to understand AL dynamics within rivers, which will improve global models of AL movement and …

Go to article

Pattern, Process And The Evolution Of Sexual Dimorphism In Three-Spine Stickleback Fish Gasterosteus Aculeatus From Vancouver Island, British Columbia, Katie Van Dame Sep 2024

Pattern, Process And The Evolution Of Sexual Dimorphism In Three-Spine Stickleback Fish Gasterosteus Aculeatus From Vancouver Island, British Columbia, Katie Van Dame

Master's Theses

Males and females of a species often differ from one another in phenotype—a phenomenon known as sexual dimorphism. Sexual dimorphism is most often attributed to sexual selection. However, sexual dimorphism also derives from natural selection when resource competition generates disruptive selection favoring specialization on different resources, resulting in niche partitioning and the evolution of dimorphism in traits related to competition. Sexual dimorphism may be an important route to increased individual fitness (i.e., more resources, more survival). For example, ecologically driven divergent selection between sexes may derive from differences in their environments, resulting in the evolution of dimorphism in traits related …

Go to article

The Scaffolding Function Of Lsd1 Controls Dna Methylation In Mouse Escs, Sandhya Malla, Kanchan Kumari, Carlos A García-Prieto, Jonatan Caroli, Anna Nordin, Trinh T T Phan, Devi Prasad Bhattarai, Carlos Martinez-Gamero, Eshagh Dorafshan, Stephanie Stransky, Damiana Álvarez-Errico, Paulina Avovome Saiki, Weiyi Lai, Cong Lyu, Ludvig Lizana, Jonathan D Gilthorpe, Hailin Wang, Simone Sidoli, Andre Mateus, Dung-Fang Lee, Claudio Cantù, Manel Esteller, Andrea Mattevi, Angel-Carlos Roman, Francesca Aguilo Sep 2024

The Scaffolding Function Of Lsd1 Controls Dna Methylation In Mouse Escs, Sandhya Malla, Kanchan Kumari, Carlos A García-Prieto, Jonatan Caroli, Anna Nordin, Trinh T T Phan, Devi Prasad Bhattarai, Carlos Martinez-Gamero, Eshagh Dorafshan, Stephanie Stransky, Damiana Álvarez-Errico, Paulina Avovome Saiki, Weiyi Lai, Cong Lyu, Ludvig Lizana, Jonathan D Gilthorpe, Hailin Wang, Simone Sidoli, Andre Mateus, Dung-Fang Lee, Claudio Cantù, Manel Esteller, Andrea Mattevi, Angel-Carlos Roman, Francesca Aguilo

Faculty, Staff and Student Publications

Lysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development. Here we show that LSD1 is dispensable for mouse embryonic stem cell (ESC) self-renewal but is required for mouse ESC growth and differentiation. Reintroduction of a catalytically-impaired LSD1 (LSD1MUT) recovers the proliferation capability of mouse ESCs, yet the enzymatic activity of LSD1 is essential to ensure proper differentiation. Indeed, increased H3K4me1 in Lsd1 knockout (KO) mouse ESCs does not lead to major changes in global gene expression programs related to stemness. However, ablation of LSD1 but …

Go to article

Racial Attitudes And Perceptions Of Government Response During The Covid-19 Pandemic: Implications For Public Health Strategies., Man Hung, Jeremy D. Franklin, William A. Smith, Carlos J. Crespo, Evelyn U. Ezikwelu, Jerry Bounsanga, Martin S. Lipsky Sep 2024

Racial Attitudes And Perceptions Of Government Response During The Covid-19 Pandemic: Implications For Public Health Strategies., Man Hung, Jeremy D. Franklin, William A. Smith, Carlos J. Crespo, Evelyn U. Ezikwelu, Jerry Bounsanga, Martin S. Lipsky

Institute on Aging Publications

This study explored whether opinions about the government's role in addressing the COVID-19 pandemic vary based on demographic characteristics and racial beliefs. We hypothesized that opinions about the United States (U.S.) government's response to COVID-19 would differ based on an individual's characteristics such as age, race, and racial beliefs.

Go to article

September 5, 2024, James Madison University Sep 2024

September 5, 2024, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Go to article

Data Study Group Final Report: Uk Centre For Ecology & Hydrology (Ukceh) - Advancing Insect Biodiversity Monitoring Through Automated Sensors, Deep Learning, And Citizen Science Data, Sonny Burniston, Matthew Faith, Vitalii Kriukov, Rachael J. Laidlaw, Mahsa P. Kalashami, Farzana Rahman, Arpita Saggar, Asger Svenning, Cameron Trotter, Kaiwen Zuo, Katriona Goldmann, David Roy Sep 2024

Data Study Group Final Report: Uk Centre For Ecology & Hydrology (Ukceh) - Advancing Insect Biodiversity Monitoring Through Automated Sensors, Deep Learning, And Citizen Science Data, Sonny Burniston, Matthew Faith, Vitalii Kriukov, Rachael J. Laidlaw, Mahsa P. Kalashami, Farzana Rahman, Arpita Saggar, Asger Svenning, Cameron Trotter, Kaiwen Zuo, Katriona Goldmann, David Roy

School of Biological and Marine Sciences

Executive Summary. The overarching goal in this Alan Turing Institute Data Study Group(DSG) was to advance understanding and support conservation efforts related to insect populations and biodiversity monitoring. This was achieved through the integration of reliable and trustworthy machine learning applications, with datasets provided by the UK Centre for Ecology & Hydrology (UKCEH).Our objectives were twofold:• Develop advanced analytical techniques for generating biodiversity metrics and interactive data visualisations. These tools aim to promote stakeholder engagement and interest in biodiversity monitoring.• Enhance the transparency of decision-making in machine learning models and increase the trustworthiness of subsequent biodiversity monitoring results. Our work …

Go to article

[Discussions] Vol. 15 Iss. 2 Sep 2024

[Discussions] Vol. 15 Iss. 2

Discussions

No abstract provided.

Go to article

Societal Evolution: Descent Of Man, Chapter V And The Myth Of Progress, Jakob Hanschu Sep 2024

Societal Evolution: Descent Of Man, Chapter V And The Myth Of Progress, Jakob Hanschu

Discussions

No abstract provided.

Go to article

Faculty Spotlight: Dr. Patricia Princehouse, Christopher Carr Sep 2024

Faculty Spotlight: Dr. Patricia Princehouse, Christopher Carr

Discussions

No abstract provided.

Go to article

Euthanasia: A Cross-Cultural Analysis Of Right-To-Die Organzations And Euthanasia Legislature In The Netherlands And United States, Anjana Renganathan Sep 2024

Euthanasia: A Cross-Cultural Analysis Of Right-To-Die Organzations And Euthanasia Legislature In The Netherlands And United States, Anjana Renganathan

Discussions

No abstract provided.

Go to article

Re-Fashioning The Field: On Gender And Computer Science, Jessica Nash Sep 2024

Re-Fashioning The Field: On Gender And Computer Science, Jessica Nash

Discussions

No abstract provided.

Go to article

Faculty Spotlight: Dr. Jessica Fox Sep 2024

Faculty Spotlight: Dr. Jessica Fox

Discussions

No abstract provided.

Go to article

Biological Clock, Robert Mcduff Sep 2024

Biological Clock, Robert Mcduff

Astarte (literary magazine)

p. 3

Go to article

Astarte 2 (Front Matter), Astarte Staff Sep 2024

Astarte 2 (Front Matter), Astarte Staff

Astarte (literary magazine)

pp. -1

Go to article

Astarte 2 (Complete Issue), Astarte Staff Sep 2024

Astarte 2 (Complete Issue), Astarte Staff

Astarte (literary magazine)

No abstract provided.

Go to article

Applying Transfer Learning And Existing Eeg Datasets To Identify Patients With Als, Nibhrat Lohia, Chris Mathew, Garrett Shankel Sep 2024

Applying Transfer Learning And Existing Eeg Datasets To Identify Patients With Als, Nibhrat Lohia, Chris Mathew, Garrett Shankel

SMU Data Science Review

Convolutional neural networks (CNNs) have helped medical practitioners re-design the diagnosis of electroencephalogram (EEG) recordings, resulting in a level of accuracy and efficiency that matches or exceeds experts in the field. This study aims to explore the application of VGG19, an algorithm based on CNN architecture, to diagnose small subsets of neurodegenerative diseases, specifically amyotrophic lateral sclerosis (ALS), a disease that reduces the nervous system’s ability to control the muscles of the body. Since EEG recordings are scarce for ALS, this study will use a larger collection of EEG recordings taken on patients with more common neurological diseases, including but …

Go to article

Rethinking Retrieval Augmented Fine-Tuning In An Evolving Llm Landscape, Nicholas Sager, Timothy Cabaza, Matthew Cusack, Ryan Bass, Joaquin Dominguez Sep 2024

Rethinking Retrieval Augmented Fine-Tuning In An Evolving Llm Landscape, Nicholas Sager, Timothy Cabaza, Matthew Cusack, Ryan Bass, Joaquin Dominguez

SMU Data Science Review

This study explores the utilization of Retrieval Augmented Fine-Tuning (RAFT) to enhance the performance of Large Language Models (LLMs) in domain-specific Retrieval Augmented Generation (RAG) tasks. By integrating domain-specific information during the retrieval process, RAG aims to reduce hallucination and improve the accuracy of LLM outputs. We investigate the use of RAFT, an approach that enhances LLMs by incorporating domain-specific knowledge and effectively handling distractor documents. This paper validates previous work, which found that RAFT can considerably improve the performance of Llama2-7B in specific domains. We also expand upon previous work into new state-of-the-art open-source models and other datasets with …

Go to article

Volume 52-1 Complete Issue, Steven M. Schnell Sep 2024

Volume 52-1 Complete Issue, Steven M. Schnell

The Geographical Bulletin

Volume 52-1 Complete Issue

Go to article

Framing Iowa’S “Fragile Giants”, Blake L. Mayberry Sep 2024

Framing Iowa’S “Fragile Giants”, Blake L. Mayberry

The Geographical Bulletin

The cultural landscape of Iowa has changed significantly in the last thirty years, coincident with larger changes in the national and global economies . The Loess Hills–a geologic landform consisting of eroded 15,000-yearold deposits of eolian glacial silt spanning seven counties in western Iowa–have become a political and discursive battle ground for postindustrial restructuring . The State of Iowa sought to create a tourism- and recreationbased economy for western Iowa as a response to rural population loss and unemployment . In 1997, the state’s largest newspaper, The Des Moines Register, started an editorial campaign to advocate for a national park …

Go to article

Reconstructing Canopy Disturbance History And Recruitment Patterns To Inform Management Decisions At The Lost 40 In The Chippewa National Forest, Northern Minnesota, Julia Rauchfuss, Susy Svatek Ziegler Sep 2024

Reconstructing Canopy Disturbance History And Recruitment Patterns To Inform Management Decisions At The Lost 40 In The Chippewa National Forest, Northern Minnesota, Julia Rauchfuss, Susy Svatek Ziegler

The Geographical Bulletin

Old-growth eastern white pine (Pinus strobus) and red pine (Pinus resinosa) dominate the forest canopy but not the understory of the Lost 40 Scientific and Natural Area in northern Minnesota . Our objectives were to (1) analyze stand structure and species composition, (2) examine the tree-ring record to determine the frequency and magnitude of canopy disturbances, (3) characterize recruitment patterns to provide information for a science-based management plan, and (4) compare the canopy-disturbance history of the Lost 40 to the average decadal rate of disturbance in similar forests . Average canopy disturbance from 1880–1999 was 2 .6–8 .2 percent per …

Go to article

First Prev Next Last