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Potential Innate And Adaptive Roles Played By Γδ T Cells In A Bacterial Immunization Model, Lee Anne Talbot

Seton Hall University Dissertations and Theses (ETDs)

Francisella tularensis is a highly infectious intracellular bacterium and the causative agent of tularemia, with pulmonary infection resulting in severe disease and high mortality if untreated. While protective immunity to F. tularensis has been largely attributed to CD4⁺ T cell–mediated IFN-γ responses, the contribution of γδ T cells to mucosal immunity and vaccine-induced protection remains poorly defined. The objective of this study was to characterize the role of γδ T cells during primary pulmonary infection with F. tularensis live vaccine strain (LVS) and following intranasal immunization with inactivated F. tularensis (iFt) prior to LVS challenge.

Using a murine intranasal infection …

Exploring Health Insurance’S Role In Chronic Disease Management Among Hispanics, Romelyn Dones

Seton Hall University Dissertations and Theses (ETDs)

This qualitative study examined how insured non-English- and English-speaking Hispanic adults perceive the role of health insurance in the management of chronic disease. Chronic conditions remain a leading cause of morbidity in the United States, and although prior research suggests that insurance coverage improves access to care, it does not always enhance how individuals understand or utilize support for chronic disease management. Limited research has explored how individuals with chronic conditions interpret the role of insurance in their daily self-management practices, particularly among Hispanic populations. Guided by Andersen’s Behavioral Model of Health Services Use, this study explored how contextual, enabling, …

Eat Or Be Eaten: A Posthuman Ecofeminist Reading Of The Vegetarian And Organ Meats, Erin Grace Elizabeth Kostic

Seton Hall University Dissertations and Theses (ETDs)

As two novels that feature the reformation and reconstruction of the female body, both Han Kang’s The Vegetarian and K-Ming Chang’s Organ Meats emphasize the posthuman existence of women seeking to break free from the gender-based shackles that constrain them, leading to a striking rejection of the anthropocentric and patriarchal worldviews that plague contemporary society. My thesis comparatively examines each novel through an ecofeminist lens in an attempt to prove that it is only when a woman is able to reframe her existence outside of a male-centric worldview that she can truly find freedom. The Vegetarian’s Yeong-hye loses her …

Semi-Rational Strategies For Antifungal Peptide Design, Akilah I. Mateen

Seton Hall University Dissertations and Theses (ETDs)

A recently emerged opportunistic fungi, Candida auris, has been subject to increased scrutiny due to its virulence and rapid geographical spread. Due to the indiscriminate use of antimicrobials as treatments for infectious diseases and as pesticides, the ubiquitous threat of multidrug resistance (MDR) looms large. The lack of progress in antifungal development is of high concern in the treatment of infectious diseases and a rise in fungal resistance highlight the need for updated treatment strategies. This work describes three strategies used to address these concerns:

•  The synthesis of a photosensitizer-membrane-active peptide (PS-MAP) conjugate, Ir-HKII15, that combines the ability of …

They Can’T “Shut Us Up”: Emily Dickinson’S And Mina Loy’S Use Of Religious Struggles In Girlhood To Empower Their Feminist Poetic Voices As Women, Bridget H. Anderson

Seton Hall University Dissertations and Theses (ETDs)

Poet Emily Dickinson and Modernist poet Mina Loy’s works stand the test of time to create a striking religious and feminist narrative today. Dickinson’s poetry, which remained largely unknown in her lifetime, will come to wield great power in the feminist and religious spheres in the years following her death in 1886. Following in Dickinson’s footsteps, Loy’s poetry is direct and engaging in a more urgent message with her bold imagery and brash words. Dickinson’s “We talked as Girls do” (392) and “They shut me up in Prose” (445) are texts that subtly challenge the misogyny in the Calvinist religion …

Exploring Direct Support Professionals' (Dsps) Attitudes Regarding Trauma Informed Care And Its Impact On Turnover Intention, Lorraine D'Sylva-Lee

Seton Hall University Dissertations and Theses (ETDs)

The relationship between Direct Support Professionals’ (DSPs’) attitudes toward trauma-informed care (TIC) and their turnover intention has remained empirically untested, despite DSPs’ exposure to primary and secondary trauma. An estimated 8.38 million Americans with intellectual and developmental disabilities (IDD) depend on this workforce, yet 2024 turnover rates reach 53.7%. This convergent mixed methods study examined TIC attitudes, turnover intention, and their relationship among 109 DSPs in IDD provider agencies in New Jersey. Grounded in the Theory of Planned Behavior (TPB), the cross-sectional design used the ARTIC-10, TIS-6, and two open-ended items. DSPs with more favorable TIC attitudes were significantly less …

Centering Testimonio: Understanding Chronic Absenteeism Through The Eyes Of Multilingual And Newcomer Families, Alexandra Sanchez

Educational Studies Dissertations

Chronic absenteeism remains a persistent concern in K–12 education and is often framed through deficit-based narratives that place blame solely on students or families. This qualitative study examines how a multilingual learner (MLL) and newcomer caregiver understands and experiences school attendance within her child’s public charter school community. Grounded in testimonio as both a methodological and epistemological approach, this study centers the lived experiences and knowledge of a caregiver navigating schooling within a new sociocultural and linguistic context.

Data were collected through in-depth, semi-structured interviews conducted in Spanish and subsequently translated into English for analysis. An inductive coding process was …

What Are You?: The Impacts Of Salient Relationships And Monoracist Experiences On Multiracial Individuals’ Well-Being, Annika E. Duquet

Doctoral Dissertations

The multiracial population is one of the fastest growing groups as interracial partnerships continue to rise (Lee, 2008). This dissertation focused on multiracial Indian and white individuals and explored the processes of developing one’s identity and social relationships through identifiable experiences. The adult participants, located throughout the United States, recalled experiences from throughout their life that they encountered with peers, family members, community members, romantic partners, and other systems of support. Using Interpretive Phenomenological Analysis (IPA) methodology, the research questions guiding the study were: 1) What are the ways in which salient relationships affect an Indian and white individual’s meaning-making …

Racial Identity In Horror: The Fear Of Black Female Sexuality, Charniece D. Bacon

Honors College Theses

The Jezebel stereotype is a racial stereotype with biblical ties that portrays black women as seductive, sexually insatiable beings. The horror genre explores humanity’s biggest fears and anxieties by looking at subgenres such as blaxploitation and vampirism. In this essay, I'll explore the intersectionalities of race, gender, and religion through the portrayal of black female sexuality in the horror genre. In films such as Ganja & Hess (1973), Abby (1976), and Def by Temptation (1990), they all depict the Jezebel stereotype. In an in-depth analysis of these films, I'll go over the ways in which they reinforce the Jezebel stereotype, …

Virus-Like Particle Peptoid Conjugate As A Triple-Negative Breast Cancer Targeting Delivery System, Ricky Zhu

Chemistry Theses

Triple-negative breast cancer (TNBC), an aggressive form of breast cancer, characterized by its lack of estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptors (HER2) poses a therapeutic challenge as common treatment options are rendered ineffective. Here is a strategy to develop a drug delivery system utilizing poly-glycinated LC129 8, a TNBC targeting peptoid, covalently attached to HK97 virus-like particles (VLP) containing a C-terminal LPETG sequence via a sortase mediated reaction. Using the properties of the cage-like structure of VLPs and the TNBC specificity of the LC129-8, high doses of chemotherapy can be efficiently loaded into the …

Proceedings Of The 18th Indonesian Occupational Medicine Update (Iomu) 2026 - Occupational Medicine Without Borders: Emerging Risks, Evolving Workforces, And Inclusive Collaboration, Indonesian Association Of Occupational Medicine Specialists (Perhimpunan Kedokteran Okupasi Indonesia / Perdoki)

Occupational and Environmental Medicine Journal of Indonesia

This Supplemental Issue of the Occupational and Environmental Medicine Journal of Indonesia (OEMJI) compiles the scientific abstracts presented at the 18th Indonesian Occupational Medicine Update (IOMU) 2026, convened in Surabaya, Indonesia, from 15 to 17 May 2026. The IOMU has matured into the most prominent annual scientific platform of the Indonesian occupational medicine community, hosted by the Indonesian Association of Occupational Medicine Specialists (Perhimpunan Kedokteran Okupasi Indonesia / PERDOKI). Since its inception, the conference has served as a meeting point where clinicians, academics, industrial hygienists, regulators, employers, and worker representatives gather to translate emerging scientific evidence into …

Gut Dysbiosis And Microbial Metabolites In Atopic Dermatitis: Implications For Immune Regulation Along Gut-Skin Axis, Khushbakhat Alia, Hira Khan, Hamna Muzaffar, Nighat Perveen, Sara Alrashedi, Yusra Al Dhaheri, Yasir Waheed, Mohammed Tauqeer Alam, Muhammad Naseem, Khalid Muhammad

All Works

Atopic dermatitis (AD) is a multifactorial skin disorder characterized by immune dysregulation, impaired epidermal barrier, and strong microbial imbalance. Although genetic susceptibility and environmental triggers are established AD drivers, growing evidence highlights the gut skin axis as an important but underexplored AD pathogenesis factor. Gut microbiota dysbiosis, loss of short-chain fatty acid (SCFA)-producing bacteria, and altered metabolite profiles, such as tryptophan derivatives and secondary bile acids, have been linked to systemic immune imbalance and skin inflammation. However, the precise mechanism by which gut microbial alterations influence cutaneous immunity remains unclear. This review synthesizes recent advances from clinical and experimental studies …

The Purdue Rising Scholars Experience: Exploring Student Success, Robert M. Stwalley Iii, Carol S. Stwalley, Roger Tormoehlen

Purdue University Press Books

Many intelligent low-socioeconomic status high school students correctly view STEM majors as a way out of poverty, but the challenges to ultimate success are plentiful. For those who applied but did not initially gain admittance into an engineering department, the Rising Scholars program at Purdue University offered these undergraduates a pathway through college that brought them into contact with a network of professional mentors, including university professors, staff, and graduate students. Program participants were also provided opportunities to engage in team-building activities and teaching seminars that involved writing research papers focused on postgraduate careers. Although no longer in operation, the …

Accuracy Of Parameter Estimation For A Simple Gene Regulatory Network Model Is Sensitive To Network Motif, Number Of Parameters Estimated, And Magnitude And Direction Of Regulatory Relationships, Nikki C. Chun, Kam Dahlquist

Honors Thesis

A gene regulatory network (GRN) is a set of transcription factors that regulate the expression of genes encoding other transcription factors. The dynamics of a GRN explain how gene expression changes over time. GRNmap is a MATLAB software package that uses ordinary differential equations to model dynamics of small-scale GRNs. We used the program to estimate production rates, expression thresholds, and regulatory weights for each transcription factor in three related literature-derived GRNs based on yeast cold shock microarray data previously collected in the Dahlquist Lab. We noticed large differences in estimated weight values when 1-2% of the expression values were …

Increasing Evolution Acceptance Among Religious Adults Through Targeted Education, Jamie Jensen

ScholarsArchive Data

These data come from a study measuring the effectiveness of the Shareable Home Application for Reconciling Evolution (SHARE) tool, which consists of five short videos addressing the nature of science, compatibility between doctrine of the Church of Jesus Christ of Latter-day Saints and evolution, evolutionary mechanisms, and evidence for evolution, including human evolution.

The Competition Between Splicing And 3′ Processing Shapes The Human Transcriptome, Lindsey V. Soles, Shuangyu Li, Liang Liu, Kristianna S.K. Sarkan, Erik G. Alvstad, Lusong Tian, Yoseop Yoon, Marielle Valdez, Ivan Marazzi, Yongsheng Shi

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Eukaryotic pre-mRNA processing steps, including splicing and 3′ processing, are tightly coordinated, yet the underlying mechanisms remain incompletely understood. U1 snRNP has been proposed to inhibit 3′ processing at intronic polyadenylation (IPA) sites through a splicing-independent mechanism termed telescripting. In contrast, we discovered that disrupting splicing by using six different methods—targeting various key components such as U1 snRNP, U2 snRNP, U2AF, and SF3b—activates 3′ processing at thousands of IPA sites. Notably, splicing inhibition, especially of U1 snRNP, induced widespread premature transcription termination within gene bodies through both IPA-coupled and IPA-independent mechanisms. Inhibition of different splicing factors activated overlapping and distinct …

The Lived Experiences Of Mississippi School Leaders Addressing Food Insecurity In Their Schools, Krista Vowell Nicholson

Theses and Dissertations

Title of Study: The lived experiences of Mississippi school leaders addressing food insecurity in their schools Pages in Study 135 Candidate for Degree of Doctor of Philosophy Food insecurity among children in the United States remains a significant concern for educational leaders. Researchers have consistently found a relationship between food insecurity and diminished student academic outcomes. The purpose of this qualitative phenomenological study was to examine how school leaders and teachers in schools in Mississippi describe their lived experiences responding to students dealing with food insecurity. The research study included semi-structured interviews with 12 principals and teacher leaders from four …

Ecological And Nutritional Drivers Of Floral Fidelity In Wild Pollinators, Adelaide Elise Ergastolo

Master's Theses

Plants must receive pollen from the same species in order to successfully reproduce. For most flowering plants, the transfer of pollen occurs via animal pollinators while they forage on plants to obtain food. Therefore, the fidelity of pollinators to individual plant species during foraging trips is directly related to the amount of conspecific pollen plants receive. Low floral fidelity of pollinators can reduce plant reproductive success, which in turn has the potential to lower food resources for pollinators in the future. While many factors can potentially influence pollinator floral fidelity, several important ones may be the nutritional resources provided by …

Vegetated Canopy Heterogeneity Footprints In The Roughness Sublayer, Giulia Salmaso, Raul Bayoan Cal, Marc Calaf

Mechanical and Materials Engineering Faculty Publications and Presentations

Turbulent flows over horizontally homogeneous rough surfaces are categorized as rough‐wall boundary layer flows, while flows over homogeneous vegetated canopies are better described through a mixing‐layer analogy. At present, numerous studies have investigated canopy density as a transition mechanism between rough‐wall and mixing‐layer‐type flows. Yet, most considered canopies have been spatially homogeneous, with few exceptions investigating agricultural arrangements. However, most vegetated canopies are not homogeneously distributed, but instead contain gaps and spatial heterogeneities of different scales. In these cases, it remains unclear which are the dominant flow traits, and how spatial heterogeneity affects them. To help overcome these knowledge gaps, …

Realizing Reality — C.S. Lewis And The Hierarchical Model Of Christian Neo-Platonism, Jordan Spina

Doctor of Philosophy Dissertation

Spina, Jordan, H. “Realizing Reality: C.S. Lewis and the Hierarchical Model of Christian Neo-Platonism.” Ph.D. diss., Concordia Seminary, 2025. 253.

In recent years there has been a growing interest in C.S. Lewis’ intellectual relationship to the Medieval cosmological model. Scholars have demonstrated that, for Lewis, the Medieval cosmological model represented more than a scientific picture of earth in relation to other heavenly bodies. Its significance was not dependent upon the number of planets or the order in which they were positioned. Instead, it represented a philosophically robust view of reality

However, what has yet to be demonstrated is the roadmap …

Losing The Body: Tracing Corporeality As A Component Of The Imago Dei Through Early Christian Exegesis, Andrew Kneeland

Doctor of Philosophy Dissertation

Kneeland, Andrew R. “Losing the Body: Tracing Corporeality as a Component of the Imago Dei Through Early Christian Exegesis.” Ph.D. diss., Concordia Seminary, 2025. 252pp.

This dissertation examines the interpretation of imago Dei in Gen. 1:26 across early Christian history, revealing both a robust tradition of corporeal emphasis and a shift toward a spiritual consensus that was driven not by immediate, unanimous consensus but a variety of pastoral and polemical factors. Far from a fleeting, anthropomorphic error, a bodily understanding of the image of God spans diverse provenances and contexts. Organized diachronically and topically, the study begins with textual exegesis …

Evaluating Computer-Based Instruction To Improve Teacher Competence In Function-Based Antecedent Strategy Implementation, Valentina Arias

Seton Hall University Dissertations and Theses (ETDs)

Teachers often manage challenging student behaviors without formal training in behavior analysis, which can increase stress and reduce instructional time. This study evaluated whether computer-based instruction (CBI) is an effective and cost-effective way to train early education teachers to understand why challenging behaviors occur and how to prevent them, using antecedent strategies. Ten general education teachers working in a private, neurodiverse-inclusive school participated. They completed a brief training delivered through computer modules developed in PowerPoint that taught them how to identify functions of behavior and select functionally equivalent antecedent strategies to decrease challenging behaviors. Learning was measured using pre/post tests …

Who Am I As An Elementary Cs Teacher? The Identity Development And Struggles Of Elementary Teachers As Computer Science Teachers, Burak Sahin

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study investigates how elementary teachers develop and negotiate their identities as computer science (CS) teachers within the expanding presence of CS in early K–12 education. As CS is increasingly integrated into early grades, many teachers are expected to teach it without formal preparation. It positions them to simultaneously learn, teach, and construct a professional identity in an unfamiliar domain. Using an interpretive phenomenological approach, this study examines teachers’ lived experiences of identity development by drawing on identity theory (Gee, 2000) and the performance, recognition, and competence framework (Carlone & Johnson,2007) to understand how identity is shaped through practice, institutional …

Addressing Sexual Health For Older Veterans By Healthcare Providers: A Mixed Method Study, Andrew James White

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Older adults remain sexually active, yet sexual health is frequently under-discussed in healthcare settings, particularly within veteran populations. Sexual health is essential to overall quality of life, and prior studies have shown that older patients value these conversations. However, veterans often face unique factors such as military-related trauma, including military combat exposure and post-traumatic stress disorder, in addition to compounded stigma from these topics in regards to open discussions about sensitive health issues to their healthcare providers. This study is significant in its potential to uncover systemic, cultural, and interpersonal influences that shape these dynamics, with a particular emphasis …

From Flight To Hatching: Adult Sexual Dimorphism, Life History, And Egg-Stage Ecology Of Pseudocotalpa Giulianii, Mandylene Mountain

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Nevada endemic dune beetle Pseudocotalpa giulianii is currently known only from two dune systems in Amargosa Valley, Nevada, yet much of its life cycle occurs below the sand surface and remains poorly documented. This thesis addresses key gaps in adult-stage biology and egg-stage development that are relevant to understanding reproduction, vulnerability, and habitat requirements in this dunerestricted species.

To characterize adult sexual dimorphism and life history, I quantified morphological differences between males and females and measured sex-specific adult survival under laboratory conditions relative to the aboveground flight season. Males and females overlapped broadly in external body size, but tarsal …

Skin Of Frog And Scale Of Dragon: Nutritional Cues, Life Cycle Kinetics, And Secretome Dynamics In Batrachochytrium Dendrobatidis, Naomi C. Okada

UNLV Theses, Dissertations, Professional Papers, and Capstones

Nearly 50% of amphibian species are at risk of extinction, making them the most threatened group of vertebrates on the planet. A major driver of these declines is the pathogenic chytrid fungus Batrachochytrium dendrobatidis (Bd), which causes the fatal skin disease chytridiomycosis. Since its discovery in the late 1990s, Bd has been directly implicated in the extinction of 90 species of amphibians and the declines of hundreds more. Despite this devastating ecological impact, relatively little is known about its basic cellular biology.

Bd has a multi-stage asexual life cycle consisting of a motile and infectious zoospore, which encysts (into a …

Correlation Between Maxillary Sinus Volume And Maxillomandibular Size, Position, And Dental Occlusion: A Cbct Retrospective Study, Philip Villanueva Punzalan

UNLV Theses, Dissertations, Professional Papers, and Capstones

This investigation used cone beam computed tomography (CBCT) based three dimensional imaging to evaluate correlations between maxillary sinus volume and maxillomandibular skeletal size, position, and dental occlusion in an adult orthodontic population. A retrospective sample of 107 pretreatment CBCT scans (40 males and 67 females), aged 18–59 years, was analyzed. Right and left maxillary sinuses were segmented independently using semi-automatic volumetric segmentation in ITK-SNAP software, and total sinus volume was calculated in cubic millimeters (mm³). Linear and angular skeletal measurements of the maxilla and mandible were obtained using Anatomage TxSTUDIOViewer application software. Patients were categorized according to anteroposterior (A-P) skeletal …

Examining The Relationships Among Collaborative Teaching Practices, Self-Efficacy, And Teachers' Self-Regulation In Charter School Culture, Melissa J. Seltenreich

UNLV Theses, Dissertations, Professional Papers, and Capstones

This dissertation examined the relationships among collaborative teaching practices, teacher selfefficacy, and self-regulation among 226 in-service K–12 teachers in Southern Nevada public charter schools. Teaching is a demanding profession that requires strong self-regulation (goal setting, monitoring, reflection, and adaptive strategies) and self-efficacy to sustain effective instruction, teacher well-being, and professional longevity. Collaborative teaching practices, which emphasize teamwork, shared planning, and peer support, were hypothesized to strengthen these psychological capacities within charter environments characterized by high autonomy and accountability. This research study focuses on 3 questions including demographic and situational variables that contribute to differences in teachers’ self-regulation, teachers with higher …

Navigating The Unknown: Understanding The Impact Of Mentorship For First-Generation Students In Stem, Shanika Roshanie Wickramarachchi

UNLV Theses, Dissertations, Professional Papers, and Capstones

First-generation students often encounter systemic barriers and inequities in academic pursuits related to science, technology, engineering, and math (STEM). Many institutions implement mentoring programs to mitigate these challenges; however, the effectiveness of STEM mentoring relationships for first-generation college students has been underexplored in the empirical literature. The current study centers the voices of first-generation college students to explore how mentors and institutions can better support their success through STEM mentoring relationships. In addition, this study examines how mentors’ generational status informs how they approach mentoring relationships with first-generation mentees. Participants included mentors and first-generation mentees in STEM research mentoring relationships …

Visual Interpretability Of Multimodal Tissue Perfusion Classification Using Grad-Cam And Saliency Maps, Metehan Zorluoglu

UNLV Theses, Dissertations, Professional Papers, and Capstones

Accurate identification of the tissue perfusion phase from hand images can aid doctors in decision-making with non-invasive techniques. The present study proposes a multimodal deep learning model for classifying the tissue perfusion phase using infrared, thermal, and visible spectrum images of the human hand. The proposed model consists of various preprocessing techniques such as manipulation, homography alignments, and masking. The significant contribution of this thesis is the interpretability analysis of deep learning models, achieved through the analysis of saliency maps and the Gradient-weighted Class Activation Mapping (Grad-CAM) methods. The purpose of this method is to find out how the convolutional …