Digital Commons Network^™

Vglut2-Based Glutamatergic Signaling In Central Noradrenergic Neurons Is Dispensable For Normal Breathing And Chemosensory Reflexes, Yuan Chang, Savannah Lusk, Andersen Chang, Christopher S Ward, Russell S Ray

Faculty, Staff and Students Publications

Central noradrenergic (NA) neurons are key constituents of the respiratory homeostatic network. NA dysfunction is implicated in several developmental respiratory disorders including Congenital Central Hyperventilation Syndrome (CCHS), Sudden Infant Death Syndrome (SIDS), and Rett Syndrome. The current unchallenged paradigm in the field, supported by multiple studies, is that glutamate co-transmission in subsets of central NA neurons plays a role in breathing control. If true, NA-glutamate co-transmission may also be mechanistically important in respiratory disorders. However, the requirement of NA-derived glutamate in breathing has not been directly tested and the extent of glutamate co-transmission in the central NA system remains uncharacterized. …

Creb-Binding Protein/P300 Bromodomain Inhibition Reduces Neutrophil Accumulation And Activates Antitumor Immunity In Triple-Negative Breast Cancer, Xueying Yuan, Xiaoxin Hao, Hilda L Chan, Na Zhao, Diego A Pedroza, Fengshuo Liu, Kang Le, Alex J Smith, Sebastian J Calderon, Nadia Lieu, Michael J Soth, Philip Jones, Xiang Hf Zhang, Jeffrey M Rosen

Faculty, Staff and Students Publications

Tumor-associated neutrophils (TANs) have been shown to promote immunosuppression and tumor progression, and a high TAN frequency predicts poor prognosis in triple-negative breast cancer (TNBC). Dysregulation of CREB-binding protein (CBP)/P300 function has been observed with multiple cancer types. The bromodomain (BRD) of CBP/P300 has been shown to regulate its activity. In this study, we found that IACS-70654, a selective CBP/P300 BRD inhibitor, reduced TANs and inhibited the growth of neutrophil-enriched TNBC models. In the bone marrow, CBP/P300 BRD inhibition reduced the tumor-driven abnormal differentiation and proliferation of neutrophil progenitors. Inhibition of CBP/P300 BRD also stimulated the immune response by inducing …

Myotube Guidance: Shaping Up The Musculoskeletal System, Aaron N Johnson

2020-Current year OA Pubs

Myofibers are highly specialized contractile cells of skeletal muscles, and dysregulation of myofiber morphogenesis is emerging as a contributing cause of myopathies and structural birth defects. Myotubes are the myofiber precursors and undergo a dramatic morphological transition into long bipolar myofibers that are attached to tendons on two ends. Similar to axon growth cones, myotube leading edges navigate toward target cells and form cell-cell connections. The process of myotube guidance connects myotubes with the correct tendons, orients myofiber morphology with the overall body plan, and generates a functional musculoskeletal system. Navigational signaling, addition of mass and volume, and identification of …

Adamts12 Promotes Fibrosis By Restructuring Extracellular Matrix To Enable Activation Of Injury-Responsive Fibroblasts, Konrad Hoeft, Benjamin D. Humphreys, Et Al.

2020-Current year OA Pubs

Fibrosis represents the uncontrolled replacement of parenchymal tissue with extracellular matrix (ECM) produced by myofibroblasts. While genetic fate-tracing and single-cell RNA-Seq technologies have helped elucidate fibroblast heterogeneity and ontogeny beyond fibroblast to myofibroblast differentiation, newly identified fibroblast populations remain ill defined, with respect to both the molecular cues driving their differentiation and their subsequent role in fibrosis. Using an unbiased approach, we identified the metalloprotease ADAMTS12 as a fibroblast-specific gene that is strongly upregulated during active fibrogenesis in humans and mice. Functional in vivo KO studies in mice confirmed that Adamts12 was critical during fibrogenesis in both heart and kidney. …

The Estrogen Receptor-Related Orphan Receptors Regulate Autophagy Through Tfeb, Mckenna Losby, Matthew Hayes, Aurore Valfort, Danesh H Sopariwala, Ryan Sanders, John K Walker, Weiyi Xu, Vihang A Narkar, Lilei Zhang, Cyrielle Billon, Thomas P Burris

Faculty, Staff and Students Publications

Autophagy is an essential self-degradative and recycling mechanism that maintains cellular homeostasis. Estrogen receptor-related orphan receptors (ERRs) are fundamental in regulating cardiac metabolism and function. Previously, we showed that ERR agonists improve cardiac function in models of heart failure and induce autophagy. Here, we characterized a mechanism by which ERRs induce the autophagy pathway in cardiomyocytes. Transcription factor EB (TFEB) is a master regulator of the autophagy-lysosome pathway and has been shown to be crucial regulator of genes that control autophagy. We discovered that TFEB is a direct ERR target gene whose expression is induced by ERR agonists. Activation of …

Development Of A Maturity Assessment Tool To Evaluate And Strengthen National Immunization Technical Advisory Groups (Nitags), Eliza Dryer, Abigail Shefer, Shalini Desai, Lance Rodewald, Magdalena Bastías, Nathalie El Omeiri, Sidy Ndiaye, Kori Cook, Louise Henaff, Erin Kennedy

Staff and Researcher Publications

As dozens of new National Immunization Technical Advisory Groups (NITAGs) were established worldwide in the past decade, and as existing NITAGs continued to play an important role in vaccine policy, global NITAG partners recognized a need for a standardized assessment tool to evaluate and strengthen their functions. This article describes the development of the NITAG Maturity Assessment Tool (NMAT), a stepwise evaluation tool that assesses NITAGs on seven key indicators of structure and process. A draft tool was developed through an iterative, consensus-based process with an expert working group before it was piloted with an economically and geographically diverse convenience …

Systematic Review On Isolation, Purification, Characterization, And Industrial Applications Of Thermophilic Microbial Α- Amylases, Rugaiyah A. Arfah, Sarlan Sarlan, Abdul Karim, Anita Anita, Ahyar Ahmad, Paulina Taba, Harningsih Karim, Siti Halimah Larekeng, Dorothea Agnes Rampisela, Rusdina Bte Ladju

Karbala International Journal of Modern Science

The α-amylase enzyme, sourced from diverse organisms, including plants, animals, and bacteria, plays a crucial role in multiple industries, notably food processing sectors like cakes, fruit juices, and starch syrup. Research identifies thermophilic organisms as prime sources of this enzyme thriving at temperatures ranging from 41°C to 122°C. The enzyme purification was carried out using liquid-liquid extraction, which involved the exchange of substances between two liquid phases that were immiscible or partially soluble. The optimal temperature for α-amylase was 45 to 90°C. The best pH for bacterial and fungal α-amylases ranged from 5.0 to 10.5 and 5.0 to 9.0. Based …

Examining Changes In Pain Sensitivity Following 8 Minutes Of Cycling At Varying Exercise Intensities, Brandi B. Antonio, Jeffrey Stout, Danielle Sterner, Abigail Anderson, David Fukuda

International Journal of Exercise Science

International Journal of Exercise Science 17(7): 1337-1351, 2024. This study assessed the effect of an eight-minute cycling intervention using varying intensities on exercise-induced hypoalgesia (EIH). The main objective of this study was to examine the effect of varying intensities on pressure pain threshold (PPT) and heat pain threshold (HPT) at the thigh and forearm, tested pre- and post-cycling intervention. Healthy male participants (n = 16) performed a graded exercise test on a cycle ergometer to establish their peak power output (PPO). In subsequent visits, participants completed five different 8-minute cycling interventions, with intensities randomly assigned to one of three …

Inter-Individual Responses To Acute Resistance Training In The Blood Pressure Dipping Response In Normotensive And Hypertensive Men, Elizabeth Carpio-Rivera, José Moncada-Jiménez, Alejandro Salicetti-Fonseca, Andrea Solera-Herrera

International Journal of Exercise Science

International Journal of Exercise Science 17(3): 1361-1376, 2024. The blood pressure dipping response to acute resistance training exercise (RTE) is scarce in the literature. We determined the inter-individual blood pressure (BP) dipping variability of normotensive (NT) and hypertensive (HT) men completing two modalities of a single session of RTE. Volunteers (NT n = 21, HT n = 20) underwent a non-exercise control (CTRL), RTE high-sets low-repetitions (HSLR), and RTE high-repetitions low-sets (HRLS) conditions. Twenty-four-hour ambulatory BP monitoring recorded diurnal and nocturnal systolic (SBP) and diastolic (DBP) BP. Non-significant interactions were found between the category of individuals and the experimental conditions …

Physiological And Psychological Differences Between 20% Grade Incline-Walking And Level-Grade Jogging At Isocaloric Intensity, Motoki Sato, Taj Krieger, Alexis D. Gidley, Brianne Weaver, Craig A. Johnson, David E. Lankford

International Journal of Exercise Science

International Journal of Exercise Science 17(6): 1318-1336, 2024. High-incline walking is a relatively new trend with little comparative information. This study compared physiological and psychological differences between high-incline walking at 20% grade (HIW) and level-grade jogging (LGJ) at isocaloric intensities in young adults. Twenty-two participants (M = 11, F = 11) aged 19–31 years completed the study. Participants completed HIW and LGJ on a treadmill for twenty minutes on two separate occasions and matched at isocaloric intensities. Rating of perceived exertion (RPE), maintainability (HCM), and affective valence using the Feeling Scale (FS) were measured at minutes 2, 10, and 20. …

Comparison Of Lower Limb Mass, Thigh Circumference, And Balance Ability After Anterior Cruciate Ligament Reconstruction And In Control Participants, Micah B. Hebert, Laura L. Dill, Paul T. Stuhr, Deanna J. Schmidt

International Journal of Exercise Science

International Journal of Exercise Science 17(1): 1306-1317, 2024. Injury of the anterior cruciate ligament (ACL) in the knee is common, with up to 250,000 cases annually in the United States. Such injuries can lead to muscle atrophy, impaired balance, and limited movement. This study aimed to compare the lower limbs of individuals with ACL reconstruction to a Control group. We hypothesized that ACL participants would exhibit greater asymmetry between lower limbs as compared to Controls. Data were collected from 12 ACL participants and 30 Control participants. Measurements included lower limb muscle mass assessed using bioelectrical impedance, thigh circumference at 10 …

Wmdds Bulletin Winter 2020

West Michigan District Dental Society Bulletin

In the Winter 2020 issue, the reader will find the following feature articles:

• 2020 Silent Bell Recipient: W. Erick Rupprecht, DDS
• Dentists Beyond the Chair: Aquarist and Fish Breeder – Chase Klinesteker, DDS

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Fall 2020

West Michigan District Dental Society Bulletin

In the Fall 2020 issue, the reader will find the following feature articles:

• Looking to Leadership: Personal Experiences During the Pandemic
• Dentists Doing Good: WMDF Golf Outing
• Dentists Beyond the Chair: Maintaining a Pollinator Habitat and 52 Acre Farm
• 2020 WMDDS Directory Corrections/Additions

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

The Quadruple Helix Of Strategic Alliances And Its Application For Community Development In Las Acequias De Atrisco, Jorge Garcia

Regeneración: A Xicanacimiento Studies Journal

In today’s society, the development of Information Communication Technologies (ICT) is imminent yet, large segments of the world remain marginalized. I contend that peer-to-peer and inter-institutional networks can be used to connect local with global systems to close this divide. Using today’s virtual and digital technologies the gap can be bridged using collaboration platforms using different knowledge systems that do not simply replicate the same information. The suggested model represents forming strategic alliances for information sharing and collaboration to empower and support local knowledge systems. The examples discussed show our efforts toward an inclusive approach with communities in full partnership, …

Partial Purification Of Alzheimer’S Amyloid-𝛽 Specific Antibody Using Ammonium Sulfate, Noor Yousaf

Undergraduate Research Symposium

Alzheimer's disease (AD) is the most common neurodegenerative disease. The trigger for AD is the accumulation of amyloid-beta protein (Aβ) as senile plaques in the brain. Prior to forming the fiber-like structures found in the plaques, Aβ undergoes an oligomerization process that produces intermediate structures called protofibrils. Substantial data from the Nichols laboratory demonstrated that soluble Aβ protofibrils were highly inflammatory compared to other forms of Aβ. Based on these findings, a serum polyclonal antibody, named Antibody St. Louis or AbSL, was developed to target Aβ protofibrils. A significant challenge with serum antibodies is the presence of many other biological …

Little Creatures, Jane Kokernak

PoemMemoirStory (literary magazine)

pp. 82-92

Wmdds Bulletin Winter 2023

West Michigan District Dental Society Bulletin

In the Winter 2023 issue, the reader will find the following feature articles:

• Congress and the State Legislature: Is There a Difference?
• 2023 Silent Bell Recipient: Debra A. Peters, DDS
• 2023 Silent Bell Awards Night and Celebration Highlights
• Practice Perspective: My Journey into Public Health Dentistry
• Kent County Low Cost Dental Clinics

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Summer 2023

West Michigan District Dental Society Bulletin

In the Summer 2023 issue, the reader will find the following feature articles:

• Advocacy in Action: Network Leasing
• Practice Perspective: Transitions in Dental Practice

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Renal Cell Carcinoma With Metastasis To Buccal Mucosa: A Common Tumor With Uncommon Metastasis, Chruthi Saranya B, Shilpa M.D

Vedam- 2024, The Academic Fest and Undergraduate Medical Conference of KMC, Manipal

No abstract provided.

A Case Of Crohn’S Disease With Neurological Extra Intestinal Manifestations, Srikar Giduthuri, Shivashankara .

Vedam- 2024, The Academic Fest and Undergraduate Medical Conference of KMC, Manipal

No abstract provided.

An Approach To Conjugated Hyperbilirubinemia In Neonates, Debyani Kishore, Arjun Asok

Vedam- 2024, The Academic Fest and Undergraduate Medical Conference of KMC, Manipal

No abstract provided.

Effects Of Neuroticism–Anxiety And Sociability Personality Traits On The Relationship Between Testosterone And Risk Propensity In Finance, Urša Ferjančič, Fajko Bajrović, Aljoša Valentinčič

Economic and Business Review

Risky financial decisions, defined as rational calculations between expected risk and reward, are subject to various psychological and neurobiological mechanisms. In this context, the relationship between testosterone levels and risk propensity has been investigated, but the results are inconsistent. Here, the effects of some personality traits, neuroticism–anxiety and sociability, on the relationship between testosterone levels and risk propensity were examined in decisions under risk (GDT) and under uncertainty (BART). In a mixed-sex sample of 100 graduate students and experienced decision makers, we found that basal testosterone levels were positively correlated with risk propensity for decisions under risk in males with …

Inflammatory Protein Associations With Brain Mri Measures: Framingham Offspring Cohort, Jiachen Chen, Ahmed A. Y. Ahmed, Margaret F. Doyle, Michael L. Alosco, Yuan Fang, Jesse Mez, Claudia L. Satizabal, Wei Qiao Qiu, Joanne M. Murabito, Kathryn L. Lunetta

Pharmacy Faculty Scholarship

INTRODUCTION: Brain magnetic resonance imaging (MRI) and inflammatory biomarkers are crucial for investigating preclinical neurocognitive disorders. Current investigations focus on a few inflammatory markers. The study aims to investigate the associations between inflammatory biomarkers and MRI measures and to examine sex differences among the associations in the Framingham Heart Study. METHODS: Dementia and stroke-free participants underwent OLINK Proteomics profiling and MRI measurements within 5 years. Pairwise cross-sectional analysis assessed 68 biomarkers with 13 brain MRI volumes, adjusting for covariates and familial correlations. RESULTS: Elevated CDCP1, IL6, OPG, and 4E.BP1 were related to smaller total cerebral brain volume (TCBV), whereas higher …

Cyber Victimization In The Healthcare Industry: Analyzing Offender Motivations And Target Characteristics Through Routine Activities Theory (Rat) And Cyber-Routine Activities Theory (Cyber-Rat), Yashna Praveen, Mijin Kim, Kyung-Shick Choi

International Journal of Cybersecurity Intelligence & Cybercrime

The integration of computer technology in healthcare has revolutionized patient care but has also introduced significant cyber risks. Despite the healthcare sector being a primary target for cyber-attacks, research on the dynamics of these threats and practical solutions remains limited. Understanding the complexities of cyberattacks in this sector is critical, as the impact extends beyond financial losses to directly affect patient care and the protection of sensitive information. This paper applies Routine Activities Theory (RAT) and Cyber Routine Activities Theory (C-RAT) to analyze high-tech cyber victimization case studies in healthcare. The analysis explores the motivations behind these attacks and identifies …

The Utah Statesman, September 16, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Gardner-Webb Bachelor’S In Mathematics Prepares Students For Various Stem Fields, Office Of University Communications

Gardner-Webb NewsCenter Archive

Gardner-Webb University’s Bachelor of Science in Mathematics program provides students with a strong foundation in core concepts of higher mathematics, implementing both traditional and modern approaches throughout the curriculum. The program seeks to develop well-rounded graduates with strong problem-solving abilities and advanced quantitative and analytical reasoning skills who can make a positive, lasting impact on society in a variety of fields.

An Introduction To Infophilia, A Positive Psychology Of Information, Anita S. Coleman

Library Research Seminar 8: Telling Library Stories

This paper will tell some of the stories of infophilia, a positive psychology of information, avant-garde research. The goal of Brenda Dervin’s ground-breaking research was not just to develop the sense-making theory, framework, and tools, but also to “invent communication alternatives and assess their utility.” One of the ‘practice communication inventions’ of Brenda Dervin was the ‘Good news newsletter’ where she developed infosheets for doctors, schools, and medical clinics (Neill, 1992, p. 6). I am no Brenda Dervin. But I am a strongly interdisciplinary scholar who has been a tenured librarian, LIS school faculty, library director, publisher for the voiceless, …

University Of New Hampshire 2024-2025 Faculty Senate Xxix - September 16, 2024 Minutes Summary, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

Faculty Senate Xxix 2024-2025 - September 16, 2024 Agenda, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

A Comparative Analysis Of Chemotherapeutic Administrations In Inhibiting Glioblastoma Multiforme Cellular Growth Utilizing An Integration Of Differentiation-Based Growth Models And Pharmacokinetic Equations, Anagha Chethan Gowda

Journal of the South Carolina Academy of Science

Glioblastoma multiforme, a disease of grade IV astrocytoma, accounts for 60-70% of malignant brain tumors.¹ Despite its low survival rate, little is known about GBM and its treatment. The purpose of this study was to assess the comparative effectiveness of the most common drugs (temozolomide, carmustine, bevacizumab) in reducing tumor growth within GBM chemotherapy. It was hypothesized that due to their properties as alkylating agents inhibiting growth genes within GBM, temozolomide and carmustine would provide the most reduction in cellular growth mathematically.² VisualPDE simulations were used to model administration of temozolomide, carmustine, bevacizumab, and none in chemotherapy and provide the …