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2024 Issue 9 Content

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Future Development Strategy And Action Plan For World Network Of Biosphere Reserves, Yu Wei, Xiaoli Shen, Yueyu Zou, Keping Ma

Bulletin of Chinese Academy of Sciences (Chinese Version)

Global environmental governance is currently encountering serious challenges. The lack of integration between biodiversity conservation and Sustainable Development Goals (SDGs) has imposed significant stress on the Earth system. Ecologically significant regions, particularly those with limited resources, are confronted with issues such as weak governance structures and restricted developmental opportunities. As the core platform of the Man and the Biosphere Programme (MAB), the World Network of Biosphere Reserves (WNBR) serves as a global model for reconciling conservation with sustainable development. Nevertheless, it continues to face major obstacles, including insufficient alignment with international frameworks, inadequate financial and human resource allocation, limited coordination …

Contribution Of Biosphere Reserves To Global Biodiversity Conservation And Climate Change, Zhiyun Ouyang, Yunong Yao, Jun Tang, Weihua Xu, Xiaosong Li, Li Zhu, Lei Cao, Mingli Lin, Yueyu Zou

Bulletin of Chinese Academy of Sciences (Chinese Version)

Biosphere Reserves are areas recognized by UNESCO that represent key terrestrial, coastal, and marine ecosystems. These areas are strictly protected and designed to fulfill three primary functions: conserving biodiversity, promoting sustainable development, and supporting scientific research and education. As of now, 759 biosphere reserves have been established in 136 countries and regions worldwide, supporting the livelihoods of approximately 236 million people. The total area of biosphere reserves covers 7.67 million km2, accounting for 4.10% of global terrestrial area, 5.08% of freshwater surface, and 0.21% of marine areas. The reserves encompass diverse ecosystems, including 2.22 million km2 of forests, 2.24 million …

Governing Human-Nature Harmony In Protected Area Communities: Global Lessons From Unesco’S Mab Network And Evidence From China’S Biosphere Reserves, Baorong Huang, Xuetian Hu, Ling Tang, Qingyu Lu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Building human-nature harmonious communities is foundational to effective protected-area governance. Drawing on fifty years of global practice under UNESCO’s Man and the Biosphere (MAB) Programme, this study distills four practice-oriented insights: establishing co-management committees to secure the institutional basis; developing ecological branding to add value to ecological products and raise household incomes; cultivating ecological flagships to enhance international reputation and attract investment; and safeguarding cultural diversity to strengthen residents’ sense of belonging and support for management. Case materials are integrated from 34 biosphere reserves in China and an observational indicator framework is constructed and a survey-based assessment is conducted for …

Scientific Research Supports Biosphere’S Conservation —Case Study Of Dinghushan World Biosphere Reserve, Hanping Xia, Juxiu Liu, Xiankai Lu, Hai Ren

Bulletin of Chinese Academy of Sciences (Chinese Version)

Based on a brief review of the Dinghushan National Nature Reserve/Dinghushan World Biosphere Reserve, this study comprehensively reviews its scientific research progress in the past 70 years, including three stages: early ecological investigation and biodiversity monitoring; mid-term research on ecosystem structure, function, and dynamics; and recent comprehensive studies. The study also analyzes the role of scientific research in supporting biodiversity conservation, local community sustainable development, and mitigation and adaptation to global climate change in the reserve. Finally, five inspirations and suggestions are proposed to support biosphere conservation through scientific research: (1) research-based conservation has strong vitality; (2) enhancing the level …

Empowering Ecological Monitoring With Science And Technology, Driving Conservation And Development Through Innovation—A Case Study Of Wolong World Biosphere Reserve, Tingmei He, Shufeng Wang, Fan Wu, Yongfeng Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Ecological monitoring can provide basic data and decision-making support for ecological environment management and policy formulation. The technologies and methods adopted in ecological monitoring by the Wolong National Nature Reserve, located in Sichuan, China, hold extensive representativeness and influence on a global scale. Based on a review of the main monitoring practices of the Wolong World Biosphere Reserve, this paper presents the adoption of different technical paths and collaborative applications in the “sky-Earth-space integrated” monitoring, as well as the practices in promoting the “Five Ones” goals (i.e., one set of data, one platform, one set of algorithms, one cloud, and …

Integrating Protection And Development Issues Through Expansion: A Case Study Of Tianmushan-Qingliangfeng World Biosphere Reserve, Wei Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

In September 2025, the Fifth UNESCO World Congress of Biosphere Reserves will be held in Hangzhou, China. The delegates will engage in detailed discussions on key issues, including the harmonious coexistence of humans and nature, as well as balanced conservation and development. This congress will also develop a strategic and action plan for the next phase of the world biosphere reserves. The Tianmushan-Qingliangfeng World Biosphere Reserve represents China’s first successful application for world biosphere reserve achieved through an expansion process. Here, this study first elucidates the value and significance of expanding world biosphere reserves. Subsequently, drawing on the practical experience …

Transboundary Conservation Of Biosphere: Case Study From Xishuangbanna World Biosphere Reserve, Lin Wang, Lifan Wang, Xiaoyan Yi, Yun Yang, Ruichang Quan

Bulletin of Chinese Academy of Sciences (Chinese Version)

Transboundary conservation, as a pivotal strategy in addressing the global biodiversity crisis, plays a critical role in maintaining ecological connectivity and promoting regional ecological security and sustainable development. Under the initiative of the Xishuangbanna World Biosphere Reserve and with bilateral governmental support from China and Laos, a contiguous transboundary protected area spanning approximately 220 km and encompassing 200 000 hectares was established along their shared border in 2012. This study elucidates the importance of transboundary conservation. Using the Xishuangbanna World Biosphere Reserve as a case study, the joint efforts between China and Laos are examined, and the effectiveness in the …

Developing Integrated Protected Area Communities: Insights From Gaoligongshan Unesco Biosphere Reserve, China, Jianwei Chen, Ling Tang, Ying’An Zhang, Shihai Yu, Hui Yang, Yuanmengran Chu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The integrated protected area community (IPAC) model is a Chinese innovation in protected area governance, emerging from the convergence of national policy support, local government implementation, and community participation. Rather than relying solely on administrative jurisdiction or geographic proximity, IPAC uses protected areas as institutional hubs to align ecological conservation with community development and regional collaboration. Based on the case of the Gaoligongshan UNESCO biosphere reserve, this study examines how policy coordination, stakeholder integration, and ecological value realization are operationalized under the IPAC approach, highlighting an integrated mechanism that combines state-led planning, multi-entity co-governance, and ecological product valorization. The Gaoligongshan …

Tumor-Infiltrating Nerves Functionally Alter Brain Circuits And Modulate Behavior In A Mouse Model Of Head-And-Neck Cancer, Jeffrey Barr, Austin Walz, Anthony C Restaino, Moran Amit, Sarah M Barclay, Elisabeth G Vichaya, William C Spanos, Robert Dantzer, Sebastien Talbot, Paola D Vermeer

Faculty, Staff and Student Publications

Cancer patients often experience changes in mental health, prompting an exploration into whether nerves infiltrating tumors contribute to these alterations by impacting brain functions. Using a mouse model for head and neck cancer and neuronal tracing, we show that tumor-infiltrating nerves connect to distinct brain areas. The activation of this neuronal circuitry altered behaviors (decreased nest-building, increased latency to eat a cookie, and reduced wheel running). Tumor-infiltrating nociceptor neurons exhibited heightened calcium activity and brain regions receiving these neural projections showed elevated Fos as well as increased calcium responses compared to non-tumor-bearing counterparts. The genetic elimination of nociceptor neurons decreased …

Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp) Bres No. 52 – Moscow Dump, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp) Bres No. 78 – Original Mine Yard, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Protocol For Establishing And Evaluating A Cancer Cachexia Mouse Model, Zhijun Zhou, Jingxuan Yang, Mingyang Liu, Yu Ren, Xiuhui Shi, Yang Cai, Alex X Arreola, Yi-Ping Li, Yuqing Zhang, Min Li

Faculty, Staff and Student Publications

Cancer cachexia mouse models are needed to recapitulate the clinical features of patients with cachexia. Here, we present a protocol for the establishment and evaluation of cancer cachexia mouse models. We delineate the steps in preparing tumor cells for inoculation and surgical procedures. After the establishment of these mouse models, we describe essential techniques to assess cancer cachexia, including grip strength evaluation, tissue collection, and the calculation of cross-sectional areas of muscle tissue. For complete details on the use and execution of this protocol, please refer to Liu et al.,

The Burden Of Chronic Pain In Transgender And Gender Diverse Populations: Evidence From A Large Us Clinical Database, Tomasz Tabernacki, David Gilbert, Kyle Scarberry, Rachel Pope, Megan Mcnamara

Student Scholarship

Background: Chronic pain, affecting approximately 20% of the global population, is the leading cause of disability worldwide. Transgender individuals are disproportionately exposed to chronic pain risk factors compared with the cisgender population. This study compares the incidence of chronic pain between transgender and cisgender individuals and examines the impact of gender affirming hormone therapy, anxiety, and depression on chronic pain. Methods: The study analysed medical records data of 56,470 transgender men and 41,882 transgender women in the TrinetX database. Six cohorts were created: transgender women either receiving oestrogen or no intervention, transgender men receiving testosterone or no intervention and cohorts …

Sheared Turbulent Flows And Wake Dynamics Of An Idled Floating Tidal Turbine, Lilian Lieber, Shaun Fraser, Danny Coles, Alex Nimmo Smith

School of Biological and Marine Sciences

Ocean energy extraction is on the rise. While tides are the most predictable amongst marine renewable resources, turbulent and complex flows still challenge reliable tidal stream energy extraction and there is also uncertainty in how devices change the natural environment. To ensure the long-term integrity of emergent floating tidal turbine technologies, advances in field measurements are required to capture multiscale, real-world flow interactions. Here we use aerial drones and acoustic profiling transects to quantify the site- and scale-dependent complexities of actual turbulent flows around an idled, utility-scale floating tidal turbine (20 m rotor diameter, D). The combined spatial resolution of …

Inorganic Phosphorus Availability And Mobility In A Manufactured Soil, H Kate Schofield, Alan D Tappin, Tim R Pettitt, Gavyn K Rollinson, Mark F Fitzsimons

School of Geography, Earth and Environmental Sciences

Manufactured soils, created by combining various organic and inorganic waste materials and byproducts, may be tailored to specific applications, providing an alternative to the extraction of natural soils. It is important for them to be capable of supporting plant growth without the need for significant management or fertiliser applications, the over-application of which can have adverse environmental effects. We examined the dynamics of phosphorus (P) transformations within a manufactured soil and the implications for nutrient cycling. A freshly prepared manufactured soil (32.5 % composted green waste, 32.5 % composted bark, 25 % horticultural grit, and 10 % lignite clay) was …

Survival Outcomes After Omission Of Surgery For Ductal Carcinoma In Situ, Elizabeth C Poli, Wenli Dong, Simona F Shaitelman, Nina Tamirisa, Yu Shen, Isabelle Bedrosian

Faculty, Staff and Student Publications

Clinical trials of active surveillance (AS) for Ductal Carcinoma in Situ (DCIS) are underway. We sought to understand the historical management of biologically favorable DCIS and to determine the outcomes of patients who did not have immediate surgery. Using data from the NCDB from 2004 to 2017, the selected cohort included women >40 years of age, with low or intermediate grade and hormone receptor (HR) positive DCIS. AS was defined as either no surgery or surgery >12 months from diagnosis. Women in the AS group were compared to women who had immediate surgery. A Cochran-Armitage test was used to assess …

Fort Hays State University Tiger Weekly, September 20, 2024, University Relations

Tiger Weekly Newsletters

No abstract provided.

Protocol For The Derivation Of Primary Cancer Stem Cell Lines From Human Ependymal Tumors, Cory M Richman, Peter B Dirks, Michael D Taylor, Kulandaimanuvel Antony Michealraj

Faculty, Staff and Students Publications

Cancer stem cells (CSCs) established from surgical biopsies closely mimic the human context and can be used to investigate disease mechanisms, genetic fitness, and therapeutic evaluation. Here, we present a protocol for the derivation of primary patient-derived CSC lines from ependymal tumors. We describe the necessary steps, from surgical intervention and biopsy to the dissociation of ependymomas to derive cultures. We then detail procedures for cell line propagation and define the characteristics of these primary cancer cell lines. For complete details on the use and execution of this protocol, please refer to Michealraj et al.

A Call For Better Understanding Household Complexity In Environmental Social Science, Rebecca Nixon, Brooke Mcwherter, Anna Erwin, Jonathan Bauchet, Zhao Ma

Department of Agricultural Economics Faculty Publications

No abstract provided.

Germline Mutations In A G Protein Identify Signaling Cross-Talk In T Cells, Hyoungjun Ham, Huie Jing, Ian T Lamborn, Megan M Kober, Alexey Koval, Yamina A Berchiche, D Eric Anderson, Kirk M Druey, Judith N Mandl, Bertrand Isidor, Carlos R Ferreira, Alexandra F Freeman, Sundar Ganesan, Meliha Karsak, Peter J Mustillo, Juliana Teo, Zarazuela Zolkipli-Cunningham, Nicolas Chatron, François Lecoquierre, Andrew J Oler, Jana Pachlopnik Schmid, Douglas B Kuhns, Xuehua Xu, Fabian Hauck, Waleed Al-Herz, Matias Wagner, Paulien A Terhal, Mari Muurinen, Vincent Barlogis, Phillip Cruz, Jeffrey Danielson, Helen Stewart, Petra Loid, Sebastian Rading, Boris Keren, Rolph Pfundt, Kol A Zarember, Katharina Vill, Lorraine Potocki, Kenneth N Olivier, Gaetan Lesca, Laurence Faivre, Melanie Wong, Anne Puel, Janet Chou, Maud Tusseau, Niki M Moutsopoulos, Helen F Matthews, Cas Simons, Ryan J Taft, Ariane Soldatos, Etienne Masle-Farquhar, Stefania Pittaluga, Robert Brink, Danielle L Fink, Heidi H Kong, Juraj Kabat, Woo Sung Kim, Tatjana Bierhals, Kazuyuki Meguro, Amy P Hsu, Jingwen Gu, Jennifer Stoddard, Benito Banos-Pinero, Maria Slack, Giampaolo Trivellin, Benoît Mazel, Maarja Soomann, Samuel Li, Val J Watts, Constantine A Stratakis, Maria F Rodriguez-Quevedo, Ange-Line Bruel, Marita Lipsanen-Nyman, Paul Saultier, Rashmi Jain, Daphne Lehalle, Daniel Torres, Kathleen E Sullivan, Sébastien Barbarot, Axel Neu, Yannis Duffourd, Morgan Similuk, Kirsty Mcwalter, Pierre Blanc, Stéphane Bézieau, Tian Jin, Raif S Geha, Jean-Laurent Casanova, Outi M Makitie, Christian Kubisch, Patrick Edery, John Christodoulou, Ronald N Germain, Christopher C Goodnow, Thomas P Sakmar, Daniel D Billadeau, Sébastien Küry, Vladimir L Katanaev, Yu Zhang, Michael J Lenardo, Helen C Su

Center for Medical Ethics and Health Policy Staff Publications

Humans with monogenic inborn errors responsible for extreme disease phenotypes can reveal essential physiological pathways. We investigated germline mutations in GNAI2, which encodes Gαi2, a key component in heterotrimeric G-protein signal transduction usually thought to regulate adenylyl cyclase-mediated cAMP production. Patients with activating Gαi2 mutations had clinical presentations that included impaired immunity. Mutant Gαi2 impaired cell migration and augmented responses to T cell receptor (TCR) stimulation. We found that mutant Gαi2 influenced TCR signaling by sequestering the GTPase-activating protein RASA2, thereby promoting RAS activation and increasing downstream ERK/MAPK and PI3K-AKT S6 signaling to drive cellular growth and proliferation.

Pelage Variation And Morphometrics Of Closely Related Callithrix Marmoset Species And Their Hybrids, Joanna Malukiewicz, Kerryn Warren, Vanner Boere, Illaira L C Bandeira, Nelson H A Curi, Fabio T Das Dores, Lilian S Fitorra, Haroldo R Furuya, Claudia S Igayara, Liliane Milanelo, Silvia B Moreira, Camila V Molina, Marcello S Nardi, Patricia A Nicola, Marcelo Passamani, Valeria S Pedro, Luiz C M Pereira, Bruno Petri, Alcides Pissinatti, Adriana Alves Quirino, Jeffrey Rogers, Carlos R Ruiz-Miranda, Daniel L Silva, Ita O Silva, Monique O M Silva, Juliana L Summa, Ticiana Zwarg, Rebecca R Ackermann

Faculty, Staff and Students Publications

BACKGROUND: Hybrids are expected to show greater phenotypic variation than their parental species, yet how hybrid phenotype expression varies with genetic distances in closely-related parental species remains surprisingly understudied. Here, we investigate pelage and morphometric trait variation in anthropogenic hybrids between four species of Brazilian Callithrix marmosets, a relatively recent primate radiation. Marmoset species are distinguishable by pelage phenotype and morphological specializations for eating tree exudates. In this work, we (1) describe qualitative phenotypic pelage differences between parental species and hybrids; (2) test whether significant quantitative differences exist between parental and hybrid morphometric phenotypes; and (3) determine which hybrid morphometic …

Optimization Of Cellular Transduction By The Hiv-Based Pseudovirus Platform With Pan-Coronavirus Spike Proteins, Syamala Rani Thimmiraju, Maria Jose Villar, Jason T Kimata, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez, Jeroen Pollet

Faculty, Staff and Students Publications

Over the past three years, new SARS-CoV-2 variants have continuously emerged, evolving to a point where an immune response against the original vaccine no longer provided optimal protection against these new strains. During this time, high-throughput neutralization assays based on pseudoviruses have become a valuable tool for assessing the efficacy of new vaccines, screening updated vaccine candidates against emerging variants, and testing the efficacy of new therapeutics such as monoclonal antibodies. Lentiviral vectors derived from HIV-1 are popular for developing pseudo and chimeric viruses due to their ease of use, stability, and long-term transgene expression. However, the HIV-based platform has …

New Jersey Noir, Stephanie Dickinson

PoemMemoirStory (literary magazine)

pp. 88-102

Traffic, Heal Mcknight

PoemMemoirStory (literary magazine)

pp. 57-64

The Devil In The Details, Elena Schneider

PoemMemoirStory (literary magazine)

pp. 58-65

Gop's Future: Adapting Professional Writing To Engage And Attract Gen Z Voters, Kerry Mckim

Masters Theses

In an evolving political landscape dominated by digital media, the Republican Party faces significant challenges in connecting with Generation Z (Gen Z) voters. This thesis explores the critical role of professional writing in bridging this communication gap between generations. With the rise of social media platforms such as TikTok and YouTube, traditional communication strategies are becoming increasingly obsolete. Gen Z's unique consumption habits, values, and communication preferences necessitate reevaluating how political messages are crafted and disseminated.

This research highlights the importance of professional writing in political communication, focusing on its impact within the GOP. By examining Gen Z's demographics and …

September 19, 2024, Caa

Minutes

No abstract provided.

Gradients Of Deposition And In Situ Production Drive Global Glacier Organic Matter Composition, Amy D. Holt, Amy M. Mckenna, Anne M. Kellerman, Tom I. Battin, Jason Fellman, Eran Hood, Hannes Peter, Martina Schön, Vincent De Staercke, Michail Styllas, Matteo Tolosano, Robert G. Spencer

Faculty, Staff, and Students

Runoff from rapidly melting mountain glaciers is a dominant source of riverine organic carbon in many high-latitude and high-elevation regions. Glacier dissolved organic carbon is highly bioavailable, and its composition likely reflects internal (e.g., autotrophic production) and external (i.e., atmospheric deposition) sources. However, the balance of these sources across Earth's glaciers is poorly understood, despite implications for the mineralization and assimilation of glacier organic carbon within recipient ecosystems. We assessed the molecular-level composition of dissolved organic matter from 136 mountain glacier outflows from 11 regions covering six continents using ultrahigh resolution 21 T mass spectrometry. We found substantial diversity in …

Small Molecule Mcl-1 Inhibitor For Triple Negative Breast Cancer Therapy, Shengli Dong, Suresh K. Alahari

School of Medicine Faculty Publications

Apoptosis is an evolutionarily conserved cell death pathway that plays a crucial role in maintaining tissue homeostasis, orchestrating organismal development, and eliminating damaged cells. Dysregulation of apoptosis can contribute to the pathogenesis of malignant tumors and neurodegenerative diseases. Anticancer drugs typically possess the capacity to induce apoptosis in tumor cells. The Bcl-2 protein family, consisting of 27 members in humans, serves as the key regulator of mitochondrial function. This family can be divided into two functional groups: anti-apoptotic proteins (e.g., Bcl-2, Bcl-xl, Mcl-1) and pro-apoptotic proteins (e.g., Bad, Bax). Mcl-1 exerts its function by binding pro-apoptotic Bcl-2 proteins thereby preventing …