Digital Commons Network^™

Surface Properties Of Enamel After Using Different Bleaching Agents, Hend Sayed Ahmed

Dentistry

No abstract provided.

Indirect Composite Color Stability And Surface Roughness After Finishing, Mohamed Fouad Haridy Prof. Dr., Sara Adel Botros Dr., Nermeen Hamada Hassan

Dentistry

This study aimed to evaluate the effect of different finishing and polishing systems (one-step, two-step, and multi-step) and the application of a diamond polishing paste on color stability, surface roughness, and surface morphology of a CAD/CAM composite block. A total of seventy-seven blocks from eight composite CAD/CAM blocks were used in this study. They were divided into three main groups (22 each) according to the different finishing and polishing systems used one-step, two-step, or multi-step systems. In addition to these groups, the control group (n = 11) has no treatment. Depending on whether the polishing paste was used, each group …

Effect Of Smoking And Finishing/Polishing On Roughness Of Nanohybrid-Composite, Sara Adel Botros, Mohamed Salama Dr., Fatma Makkeyah Ass. Dr., Mohamed Shamel Ass. Prof., Mahmoud Ankily Ass. Prof.

Dentistry

To evaluate effect of conventional cigarette and heated tobacco product smoking and finishing/polishing protocol on surface roughness of a nanohybrid composite. Thirty-six discs (6mm diameter/2mm thickness) fabricated from nanohybrid composite (Palfique LX5, Tokuyama, Japan) were assigned to 6 groups according to: tobacco product (conventional cigarette/LM, Philip Morris International Inc., Egypt; and heated tobacco/Heets, Russet, Philip Morris International Inc., Italy); and finishing/polishing protocol (control /discs cured against Mylar strip; finishing discs/Diamond Master Kit, FGM, Brazil; two-step polishing system/DIACOMP PLUS TWIST, EVE, Germany). Prior to finishing/polishing protocols, all specimens were wet ground with medium grit finishing stone (komet, Germany) as baseline. Following …

Influence Of Smoking And Finishing/Polishing On Composite Color Stability, Mohamed Samy Salama Dr., Sara Adel Botros, Fatma Makkeyah Ass. Dr., Mahmoud Ankily Ass. Prof., Mohamed Shamel Ass. Prof.

Dentistry

To assess the influence of conventional cigarette and heated tobacco product smoking and finishing/polishing systems on color stability of a nanohybrid composite. Thirty-six discs (2mm thickness/6mm diameter) fabricated from nanohybrid composite (Palfique LX5, Tokuyama, Japan) were divided to 6 groups according to: tobacco product (conventional cigarette/LM, Philip Morris International Inc., Egypt; and heated tobacco/Heets, Russet, Philip Morris International Inc., Italy); and finishing/polishing system (control /discs cured against Mylar strip; finishing discs system/Diamond Master Kit, FGM, Brazil; two-step polishing system/DIACOMP PLUS TWIST, EVE, Germany). All specimens were wet ground with medium grit finishing stone (komet, Germany) as baseline before performing finishing …

Ursinus Magazine, Fall 2024, Robyn E. Hannigan, Ed Moorhouse, Gundolf Graml, Ellen Labrecque, Ben Seal, Connor Donohue, Bill Connolly

Ursinus Magazine, 1995–Present

Capital research • Atomic tech • Hall of Fame author • A winning recipe • Taking a stand • Building bridges of understanding • Cutting the ribbon on Lower Wismer • Bear bites • Doctor Broadway • Resilience in motion • Mind-blowing pollution hiding in plain sight • History unearthed • Bear Beginnings • An artist's legacy: Francoise Gilot and the Bermans • Beyond Patterson's bleachers • The Hall at 50 • Class notes • Marriages • In memoriam • Annual Report and Year in Review

Suffering As The Way To God, Marjorie Shahani

LMU Theses and Dissertations

As a spiritual director and Christian, I desire to accompany women on their journey to a deeper personal relationship with God holding in tension the suffering Servant on the cross and the hope in the resurrected Christ. I long to illuminate their understanding of self-sacrifice and denial. Participating in Jesus’ suffering on the cross must not lead to neglect of oneself, denial of one’s human dignity, or the tolerance of any form of abuse – physical, emotional or mental. I comprehend the redemptive power in suffering for the love of God, but I also know Christ invites us to rejoice …

Unrealized Potential: South Africa’S Bill Of Inaccessible Rights: What Three Cape Town Human Rights Activist Have To Say About The Adequacy Of Three Clauses In South Africa’S Bill Of Rights, Saylor Wilkes Donaldson

South Africa: Multiculturalism and Human Rights

The South African Constitution is often referred to as the most progressive constitution in the world by both locals and international academics. Its establishment would come after decades of racial abuse and discrimination which called for political and social rights for a population that had been neglected for years. Although, this sentiment quickly comes into question as soon as an individual travels more than ten kilometers outside of the Cape Town city center. This is where informal settlements and their lack of basic necessities such as clean water, proper housing structures, and consistent education become visible. The South African Bill …

The Approaches And Implications Of English Medium Of Instruction In Nepal’S Private Schools, Vivian Ko

Nepal: Development, Gender, and Social Change in the Himalaya

In this report, I discuss how English Medium of Instruction (EMI) is approached by private schools in Nepal and its implications on larger society. Nepal’s increasing demand for EMI, and thus private schools, has contributed to a variety of social issues including inaccessibility and a dying culture. By situating EMI in Nepal’s education system, I explore how the privatization of schools and the wide implementation of EMI is both a result of neoliberalism and a contributing factor to such ideologies. Observations of EMI classes and non-academic spaces on school grounds, in addition to interviews and focus groups with students and …

Dean's Report- Fall 2024, Marina K. Holz

GSBMS Dean’s Report

No abstract provided.

Hatshepsut And Akhenaten: Dualities Of Gender, Religion, And Implementation Of Queer Theory, Sadie Anderson

Theses

This paper discusses 18th Dynasty pharaohs Hatshepsut and Akhenaten and the images they portrayed during their reigns. Hatshepsut, though being female, adhered to the preconstructed image of a traditional male pharaoh while Akhenaten defied the long-established artistic canon in order to create a more androgynous pharaonic identity. Both did this to legitimize their rule, connect themselves to divinity, and interpret the duality of gender innate to Egyptian religion through their iconography. Hatshepsut’s masculine depictions cemented her as the father of the polytheistic Egyptian empire over which she reigned. Akhenaten’s more androgynous representations, on the other hand, portrayed him as both …

Therapeutic Potential Of Ceramide In Cancer Treatment, Weiyuan Wang, Bert Prince, Alexander Thorpe, Timothy Brown, Brian Barth

Faculty, Staff, and Students

Ceramides are a family of wax-like lipids that fall under the broader category of sphingolipids. A ceramide is composed of a sphingosine side chain coupled to a fatty acid via an amide linkage. Distinct from complex sphingolipids, the head of ceramide is a simple alcohol rather than a phosphate, phosphocholine, sugar, or more. The fatty acid chains of ceramide can also vary in chain length and degree of saturation. The degree of saturation may determine the biological activity of the ceramide species. Ceramides are highly abundant within the cell membrane of eukaryotic cells and are appreciated for their structural roles …

University Of Nebraska At Omaha Division Of Biomechanics And Research Development Annual Report 2022-2023, Uno Biomechanics

Biomechanics Annual Report

This report contains:

A letter from the Director: Dr. Nick Stergiou

Highlights articles

Our ne Cobre: the Center for Cardiovascular Research in Biomechanics (CRiB) articles

The Center for Research in Human Movement Variability (MOVCENTR) articles

People of UNO Biomechanics

Student Centered articles

Faculty Success articles

Education Initiative articles

Fall 2024 Graduation Survey Responses, Systems Intelligence And Data Analytics, University Of Nebraska At Omaha

Graduation

Fall 2024 Graduation survey responses master file without identifiers.

Dental Board Of California, Shun Lam, Marcus Friedman

California Regulatory Law Reporter

No abstract provided.

Infinite Queerness And American Settler Colonialism, Jeremiah A. Ho

William & Mary Journal of Race, Gender, and Social Justice

What the LGBTQ rights movement needs, especially with regard to legal challenges, is a lasting philosophical shift toward the idea that justice and equality are an infinite game rather than a finite and pragmatic one. This work here will explore why this posture is favorable at this moment—and generally in civil rights work. Beyond connecting queer sacrifice in recent Supreme Court cases to the functioning and maintenance of the American settler colonial project, this Article will posit why a strategy shift toward infinite thinking is increasingly necessary for more resolute work that results in the autonomy and equality of LGBTQ …

Three's A Crowd: Addressing Discrimination Faced By Queer De Facto Parents In Child Custody Standing Proceedings, Shannon E. Callaghan

William & Mary Journal of Race, Gender, and Social Justice

In the United States, between five percent and eight percent of adults identify as queer, and as of 2020, fifteen percent of queer couples have children in their households. While recent legal victories have expanded queer rights, family law continues to lag in affording legal recognition to “nontraditional” families. This is particularly problematic for unmarried, queer co-parents who have virtually no legal claims to the children they have raised with their partners. Current standing requirements for custody proceedings treat these de facto parents as legal strangers to their children due to the absence of biological, marital, or adoptive ties. As …

"Deep Learning For Microscope Image Denoising", Nasreen Buhn, Sriya Adunur, Guy Hagen, Jonathan Ventura

College of Engineering Summer Undergraduate Research Program

In order to avoid damaging live cells, optical microscope imaging must be conducted under low-excitation light intensity and/or short exposure times, resulting in low signal-to-noise ratios (SNR). Deep learning methods offer an effective solution for removing microscope noise, utilizing algorithms that are able to reconstruct finer features in low SNR images. This research explores the denoising capability of several deep learning methods based on PSNR and SSIM. Tested methods include traditional approaches (BMED), supervised learning (CARE and Restormer), and unsupervised methods (Noise2Fast, N2V, SSD-Unsupervised, and SASSID). The Restormer model, which employs an encoder-decoder transformer architecture and progressive learning, stood out …

Sex Differences In The Association Between Glial Fibrillary Acidic Protein And Cognitive Performance In Autosomal Dominant Alzheimer’S Disease, Taryn Gordon

Doctor of Psychology (PsyD)

The rising incidence of Alzheimer’s Disease and its disproportionate prevalence in the female sex has led to a growth in research focused on preclinical Alzheimer’s Disease and the histopathological brain changes. However, limited research has focused on preclinical changes in Autosomal Dominant Alzheimer’s Disease populations and sex differences within these unique populations. This study aimed to address gaps in the literature by examining biological markers of neuroinflammation, glial fibrillary acidic protein (GFAP), in preclinical Autosomal Dominant Alzheimer’s Disease mutation carriers and non-carriers, and its relationship with cognitive function and sex. Archival data was utilized from the Colombia-Boston biomarker study of …

An Updated Practical Guide To Taking And Defending Depositions, Gary S. Gildin

Dickinson Law Review (2017-Present)

The deposition offers a singular opportunity to handcuff the deponent to an irreversible script. Consequently, both the attorney taking the deposition and defending counsel must prepare for and conduct the deposition with equal if not greater care than the trial.

Traditionally, lawyers have used the deposition to discover facts relating to the legal elements and the credibility, perception, and recollection of the witness. However, recent breakthroughs in neuroscience as to how the brain makes decisions have revealed a different genre of evidence that will drive how the trier of fact will decide the case. Today an attorney taking a deposition …

Analysis Of Mybl1,Vxn, And Ccne2 Gene Relationships In Triple Negative Breast Cancer, Sahia M. Bryant

Theses (2016-Present)

Accounting for 15-20% of all breast cancers, triple-negative breast cancer (TNBC), is the most aggressive subtype, with the worst prognosis. In previous studies, the MYBL1 gene, which is associated with several events that are key to tumor progression, has been identified as a powerful transcriptional activator that is overexpressed in TNBC. In earlier research, our lab knocked down MYBL1 expression in a TNBC cell line and identified a subset of genes impacted by the knockdown process. MYBL1 gene is located on the chromosome 8q locus. In addition to MYBL1 we identified 2 genes, VXN and CCNE2, also located at the …

Analysis Of Isoforms Associaated With The Mybl2 Gene In Triple Negative Breast Cancer, Taylor Allen-Boswell

Theses (2016-Present)

Nearly every gene exists as transcript variants and protein isoforms. Variations of a particular gene are generated by small nuclear ribonucleoproteins which in many cases remove introns, so that exons can be joined together in varying configurations. Transcript variants are formed, which are then translated into protein isoforms. The resulting transcript variants have substantial sequence similarities; and the isoforms have substantial sequence similarities. Studies show that isoforms generated because of these processes can have different start sites and/or sizes that can lead to generations of different proteins with different biological roles in a cell. The isoforms might have different functions …

Substance Use Emergency Department Visits Among Youths With Chronic Conditions During Covid-19., Faith Summersett Williams, Isabella Zaniletti, Abbey R. Masonbrink, Robert Garofalo, Maria Rahmandar, Niranjan S. Karnik, Geri Donenberg, Lisa Kuhns

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Pediatric emergency department (ED) visits for substance use (SU) increased during COVID-19. Better understanding of trends associated with SU ED visits among youths with a chronic medical condition (CMC) is needed to target SU screening, prevention, and intervention efforts in this population.

OBJECTIVE: To describe trends in pediatric SU ED visits before and during COVID-19 among youths in the US with and without CMCs and by race and ethnicity.

DESIGN, SETTING, AND PARTICIPANTS: In this cohort study, data were obtained from 47 US children's hospital EDs in the Pediatric Health Information System (PHIS) between March 1, 2018, and March …

Batchflex: Feature-Level Equalization Of X-Batch., Joshua T. Davis, Alyssa N. Obermayer, Alex C. Soupir, Rebecca S. Hesterberg, Thac Duong, Ching-Yao Yang, Ken Phong Dao, Brandon J. Manley, G Daniel Grass, Dorina Avram, Paulo C. Rodriguez, Brooke L. Fridley, Xiaoqing Yu, Mingxiang Teng, Xuefeng Wang, Timothy I. Shaw

Manuscripts, Articles, Book Chapters and Other Papers

MOTIVATION: Integrative analysis of heterogeneous expression data remains challenging due to variations in platform, RNA quality, sample processing, and other unknown technical effects. Selecting the approach for removing unwanted batch effects can be a time-consuming and tedious process, especially for more biologically focused investigators.

RESULTS: Here, we present BatchFLEX, a Shiny app that can facilitate visualization and correction of batch effects using several established methods. BatchFLEX can visualize the variance contribution of a factor before and after correction. As an example, we have analyzed ImmGen microarray data and enhanced its expression signals that distinguishes each immune cell type. Moreover, our …

The Importance Of Probes In Assessing Periodontal Health, Khrystyna Vyprynyuk, Catherine Monchik

Publications and Research

No abstract provided.

Characterization Of Developmentally Downregulated Nfe2l3 In Retinal Ganglion Cell Survival And Axon Regeneration, Lucy Homer

Holster Scholar Projects

Retinal ganglion cells (RGCs) are central nervous system projection neurons essential for transmitting visual information from the eye to the brain. Damage to RGCs, caused by conditions such as glaucoma and traumatic optic neuropathy (TON), may lead to vision loss or blindness, as adult RGCs lack regenerative capacity. This study focuses on Nfe2l3 (Nrf3), a developmentally downregulated transcription factor known to mediate cellular responses to oxidative stress, a key pathological event following optic nerve injury. We hypothesized that overexpressing Nfe2l3 in RGCs would enhance their survival and promote axon regeneration after optic nerve crush (ONC) injury. To test this, we …

Importance Sampling To Learn Vasopressor Dosage To Optimize Patient Mortality In An Interpretable Manner, Anshul Rastogi

Holster Scholar Projects

Sepsis is a life-threatening organ dysfunction resulting from an improperly compensated bodily response to infection. There is a high urgency among clinicians to develop a set of real-time explainable treatment guidelines and tools to address the high mortality rate of sepsis patients. We present a reinforcement learning approach for vasopressor drug dosage in intensive care unit sepsis patients to achieve a better-than-expert treatment policy. We preserved interpretability with a prototype learning layer and learn actions in an off-policy manner with importance sampling. We evaluated our design on the MIMIC-IV deidentified electronic health record dataset with an 80%-20% training-validation split for …

Understanding The Influence Of Bone Marrow Endothelial Cells On Primary Human Megakaryocytic-Erythroid Progenitor Cell Fate, Vedaamrutha Reddy

Holster Scholar Projects

The human bone marrow is a complex microenvironment comprised of hematopoietic, stromal, and bone marrow endothelial cells (BMECs). This study builds on previous findings to explore the regulatory role of BMECs in influencing the expansion and lineage choice of megakaryocytic-erythroid progenitors (MEPs). Understanding these interactions has the potential to advance transfusion medicine and improve treatments for conditions like thrombocytopenia and anemia. Due to complications with isolating human BMEC, we transitioned to a murine model. Murine BMECs were isolated and magnetic cell separation was employed to enrich for endothelial cells (ECs), which were then cultured over a 20-day period using standard …

Assessing Safety Culture: Lessons From The Aviation Industry, Mirrette Gendi, Cheri L. Marcham, Michael O'Toole

Publications

SAFETY CULTURE has been a topic of debate in academia as much as it has been in the practice of various industries (Zohar, 2010). Although the concept and definition of safety culture and what it entails have consumed much of the debate, the assessment of safety culture has been the most controversial. Yet, on the academic level, the topic of monitoring and measuring safety culture has seen limited research that offers reliable and valid assessment tools (Goodheart & Smith, 2014), especially when compared to the importance of safety culture as a component of a safety management system (SMS).

Artificial Fiduciaries, Zhaoyi Li

Washington and Lee Law Review

The rapid development of technology in the last decade has affected all levels of society. Corporate governance has not been immune to these changes. In the future, Artificial Intelligence (“AI”) fiduciaries may be technologically capable of serving as independent corporate directors. This could be an effective way to address the challenge of the absence of truly independent directors in the traditional governance framework. Artificial fiduciaries could also offer a way to mitigate agency costs and improve overall corporate governance. However, traditional corporate law lacks solutions for coping with the integration of AI into corporate governance.

Currently, there is little scholarship …

The Initial Response Of Biodiversity Conventions To The Covid-19 Pandemic, Royal C. Gardner, Lauren Beames, Katherine Pratt

William & Mary Environmental Law and Policy Review

The COVID-19 pandemic disrupted the operations of global biodiversity conventions, requiring virtual meetings in place of in-person events. Yet the pandemic also highlighted the importance of biodiversity conservation as a mechanism to reduce the risk of zoonotic diseases, as the October 2020 report issued by the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (“IPBES”) emphasized. Now that in-person, international meetings have resumed, this Article examines the extent to which four biodiversity conventions—the Agreement on the Conservation of African-Eurasian Migratory Waterbirds, the Ramsar Convention, the Convention on International Trade in Endangered Species, and the Convention on Biological Diversity—considered the nexus …