Digital Commons Network^™

Breast Cancer Molecular Subtype Classification According To Immunohistochemistry Markers And Its Association With Pathological Characteristics Among Women Attending Tertiary Hospitals In Tanzania, Allyzain Ismail, Sajida Panjwani, Neelam Ismail, Caroline Ngimba, Innocent Mosha, Philip Adebayo, Ally Mwanga, Ali Zehri, Aidan Njau, Ali Athar

Family Medicine, East Africa

Background: Breast cancer immunohistochemistry is a biological characteristic of the tumour which has a role to diagnose molecular subtype, prognosticate and guide treatment and is categorised into 4 subtypes. Data in Tanzania was lacking and was based off data extrapolated from studies in Western Africa thus hypothesizing that women of African ancestry predominately develop Triple Negative Breast Cancer (TNBC).

Methods: A retrospective cross-sectional study was carried out at two tertiary referral hospitals on participants who were recruited from the cancer registries from 2015 to 2022. Prevalence of each molecular subtype was determined and association between molecular subtype to demographic and …

Premier, Fall 2024, University Of Northern Iowa. College Of Education.

Premier

Contents:

From the Dean --- 3
/="/">The Real Deal: From Para to Educator --- 4
/="/">Extending Education Outdoors --- 8
/="/">Finding the Balance in Well-Being --- 10
/="/">A Unified Path for Early Childhood & Special Education --- 15
/="/">Resilience Redefined --- 18
/="/">Alumni Profiles --- 20
/="/">Foundation Focus --- 24
/="/">Center Spotlight --- 28
/="/">Scholarly Spotlight --- 28
/="/">News & Notes --- 30
/="/">Celebrating Excellence --- 34

Bridging The Birth Divide: Doula Perspectives On Cesarean Trends In Switzerland And The U.S., Lina Verghese

Switzerland: Global Health and Development Policy

Cesarean section (C-section) rates remain a global concern, reflecting variations in maternal care practices, healthcare access, and systemic biases. While essential in certain cases, the overuse of C-sections is linked to adverse maternal and neonatal outcomes, reinforcing medicalized approaches to childbirth. This study explores disparities in C-section rates across regions in Switzerland (Zug and Jura) and the United States (Mississippi and Alaska) and examines the role of doulas in addressing these disparities.

Using a mixed-methods approach, qualitative interviews with doulas and quantitative regional data highlight systemic and cultural influences on C-section trends. In affluent Zug, convenience and elective procedures drive …

Otterbein Towers Fall 2024, Otterbein University

Towers Magazine

Historic Milestones in Changes to Board of Trustees; Educating Students for Democracy; Belonging is This Program's Purpose; 100 Years of BAE at Otterbein University; Coalition for the Common Good: Graduate Early Admission Pathways; The Rike Center Turns 50; Philanthropy; Alumni Matters; and Class Notes.

Boise State Magazine, Anna Webb (Editor)

FOCUS on Boise State

No abstract provided.

Protecting Coastal Communities And Marine Biodiversity Under The Coastal Zone Management Act, Eric V. Hull

South Carolina Law Review

No abstract provided.

Grand Valley Magazine, Vol. 24, No 1, Fall 2024, Grand Valley State University

Grand Valley Magazine

Grand Valley Magazine is a quarterly publication about Grand Valley State University produced by University Communications since 2001.

Bridging The Gap: Factors Affecting College Students’ Use Of University Health Services, Courtney Rudolph

Honors Theses

This thesis, titled “Bridging the Gap: Factors Affecting College Students' Use of University Health Services," investigates the barriers and motivators influencing student engagement with campus health resources at Eastern Kentucky University (EKU). Given that approximately 2,000 college health centers across the U.S. serve over 20 million students, understanding why some students underutilize these services is crucial for enhancing campus health outcomes (National College Health Assessment - ACHA, 2024). Using a mixed-methods approach, the research gathered data through surveys (n = 118) and an in-depth interview with the EKU Student Health Coordinator. The study aimed to identify key factors affecting students' …

Investigating The Bioactive Properties Of The Genus Lygodium Through Phytochemical Composition Analysis, Sasha N. Carrasco

Honors Theses

Many of the secondary metabolites produced by plants serve as a chemical defense mechanism against herbivory, some of which have been utilized by humans for medicine (Kusari et al., 2014, Facchini and De Luca, 2008). While many phytochemicals have been identified in angiosperms, other major land plant lineages have received less attention despite their taxonomic diversity and putative utility. For instance, some species of monilophyte (ferns), are used medicinally by indigenous cultures to treat various ailments (Wong et al., 2018). Of focus in this manuscript is the genus, Lygodium (Sw.) which is comprised of climbing ferns exhibiting worldwide distribution. Previous …

9/11: Fueling The Misleading Fire Of War And Its Reflection In Country Music, Corban L. Profitt

Honors Theses

The interplay between American patriotism and country music underwent a profound transformation in the late 20th and early 21st centuries, as significant historical events reshaped national identity. This project examines the evolution of conservative patriotism in country music through key events such as the Iranian Revolution, the Iran-Iraq War, and the First Gulf War, culminating in the post-9/11 era and the 2003 invasion of Iraq. It explores how these geopolitical shifts influenced public sentiment and how country musicians became both commentators and amplifiers of national rhetoric. The pre-9/11 era saw artists like Merle Haggard and Hank Williams Jr. use their …

Highs And Hollows: Exploring The Overall Drug Use Of Kentucky Universities From Urban To Appalachian, Venessa Miller

Honors Theses

Drugs cause chemical changes to a person’s mental and physical state and the misuse of such substances is a problem that affects not only strangers but our community and those closest to us. It is of utmost importance to determine the root and depth of the drug problem, especially among populations where the risk is highest. College students, also known as emerging adults, are a vulnerable group due to their unique environment that fosters higher exposure rates and the normalization of substance use. The current study focuses on students in higher educational institutions throughout Kentucky, a state known for being …

2024 October, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for October of 2024.

Swosu Fact Book Fall 2024, Joel Harrel Kendall, Diane Fitzsimmons, Kelsi Burghardt

Fact Books

The 33rd annual Southwestern Oklahoma State University Fall Fact Book provides a ready source of information to answer frequently asked questions about the University and its operations. The Fall Fact Book is compiled annually by the Office of Institutional Research to assist the university with strategic planning, academic program reviews, grant writing, accreditation, and institutional information to help guide decision-making. The report uses data collected from 2015 to 2024 and is designed to help faculty, staff, administrators, and external stakeholders better understand the student body and university trends.

V.1 Fall 2024, Center For Arts & Language, Students Of Risd, Risd Archives

All Student Newspapers

v.1 is a publishing platform for the ongoing work, ideas, discussions, debates, and aspirations of students at the Rhode Island School of Design. The Fall 2024 issue contains articles on RISD Alumni Graciela Batista's Commencement speech on friendship and community, Britain's Royal Festival Hall, birds crashing into glass buildings, an Ojibwe student's reflecting on his native identity, RISD student interviews, an abandoned Bed Bath and Beyond store, Ai Weiwei's Kui Hua Zi, life in Banaras, a student's Yankee Swap experience, the 2024 RISD Grad Show, and indentations, along with student creative writing and a feature on images students saw out …

On The Pathogenesis Of Obesity: Causal Models And Missing Pieces Of The Puzzle, Faidon Magkos, Thorkild I.A. Sørensen, David Raubenheimer, Nikhil V. Dhurandhar, Ruth J.F. Loos, Anja Bosy-Westphal, Christoffer Clemmensen, Mads F. Hjorth, David B. Allison, Gary Taubes, Eric Ravussin, Mark I. Friedman, Kevin D. Hall, David S. Ludwig, John R. Speakman, Arne Astrup

Clinical Research Faculty Publications

Application of the physical laws of energy and mass conservation at the whole-body level is not necessarily informative about causal mechanisms of weight gain and the development of obesity. The energy balance model (EBM) and the carbohydrate–insulin model (CIM) are two plausible theories, among several others, attempting to explain why obesity develops within an overall common physiological framework of regulation of human energy metabolism. These models have been used to explain the pathogenesis of obesity in individuals as well as the dramatic increases in the prevalence of obesity worldwide over the past half century. Here, we summarize outcomes of a …

Extensions Of Open Science For Applied Behavior Analysis: Preregistration For Single-Case Experimental Designs, Matt Tincani, Shawn P. Gilroy, Art Dowdy

Faculty Publications

Open science practices are designed to enhance the utility, integrity, and credibility of scientific research. This article highlights how preregistration in open science practice can be leveraged to enhance the rigor and transparency of single-case experimental designs within an applied behavior analysis framework. We provide an overview of the benefits of preregistration including increased transparency, reduced risk of researcher bias, and improved replicability, and we review the specific contexts under which these practices most benefit the proposed framework. We discuss potential concerns with and unique considerations for preregistering experiments that use single-case designs, with practical guidance for researchers who are …

From Pre-Clinical Efficacy To Promising Clinical Trials That Delay Type 1 Diabetes, J. Jason Collier, Daniel S. Hsia, Susan J. Burke

Division of Basic Science Faculty Publications

Recent advancements in immunology and islet biology have unveiled remarkable prospects for the postponement of Type 1 diabetes (T1D) through the strategic modulation of the immune system. In this Perspective, we discuss the pharmaceutical strides achieved, traversing from pre-clinical validation to the execution of impactful clinical trials. We begin with the initial investigations involving cyclosporine and glucocorticoids in rodent models, such as the non-obese diabetic (NOD) mouse, which guided early clinical trials. We then discuss the pre-clinical studies using suitable mouse models that eventually led to contemporary clinical trials targeting immune cell functionality and cytokine signaling pathways. Collectively, these discoveries …

Long-Term Effects Of Climate Change On Juvenile Bull Shark Migratory Patterns, Philip Matich, Jeffrey D. Plumlee, Walter Bubley, Tobey H. Curtis, J. Marcus Drymon, Lindsay L. Mullins, Oliver N. Shipley, Thomas C. Tinhan, Mark R. Fisher

Faculty Publications

Seasonal variability in environmental conditions is a strong determinant of animal migrations, but warming temperatures associated with climate change are anticipated to alter this phenomenon with unknown consequences. We used a 40-year fishery-independent survey to assess how a changing climate has altered the migration timing, duration and first-year survival of juvenile bull sharks (Carcharhinus leucas). From 1982 to 2021, estuaries in the western Gulf of Mexico (Texas) experienced a mean increase of 1.55°C in autumn water temperatures, and delays in autumn cold fronts by ca. 0.5 days per year. Bull shark migrations in more northern estuaries concomitantly changed, with departures …

A Quantitative Adverse Outcome Pathway For Embryonic Activation Of The Aryl Hydrocarbon Receptor Of Fishes By Polycyclic Aromatic Hydrocarbons Leading To Decreased Fecundity At Adulthood, Jon A. Doering, Justin Dubiel, Eric Stock, Cameron H. Collins, Ian Frick, Hunter M. Johnson, Christopher M. Lowrey-Dufour, Justin G.P. Miller, Zhe Xia, Gregg T. Tomy, Steve Wiseman

Faculty Publications

Quantitative adverse outcome pathways (qAOPs) describe the response–response relationships that link the magnitude and/or duration of chemical interaction with a specific molecular target to the probability and/or severity of the resulting apical-level toxicity of regulatory relevance. The present study developed the first qAOP for latent toxicities showing that early life exposure adversely affects health at adulthood. Specifically, a qAOP for embryonic activation of the aryl hydrocarbon receptor 2 (AHR2) of fishes by polycyclic aromatic hydrocarbons (PAHs) leading to decreased fecundity of females at adulthood was developed by building on existing qAOPs for (1) activation of the AHR leading to early …

Prescribed Fire Regimes Influence Responses Of Fungal And Bacterial Communities On New Litter Substrates In A Brackish Tidal Marsh, Viet Q. Dao, Crystal N. Johnson, William J. Platt

Faculty Publications

Processes modifying newly deposited litter substrates should affect fine fuels in fire-managed tidal marsh ecosystems. Differences in chemical composition and dynamics of litter should arise from fire histories that generate pyrodiverse plant communities, tropical cyclones that deposit wrack as litter, tidal inundation that introduces and alters sediments and microbes, and interactions among these different processes. The resulting diversity and dynamics of available litter compounds should affect microbial (fungal and bacterial) communities and their roles in litter substrate dynamics and ecosystem responses over time. We experimentally examined effects of differences in litter types produced by different fire regimes and litter loads …

Regulation Of Bacterial Virulence Genes By Pecs Family Transcription Factors, George C. Nwokocha, Arpita Ghosh, Anne Grove

Faculty Publications

Bacterial plant pathogens adjust their gene expression programs in response to environmental signals and host-derived compounds. This ensures that virulence genes or genes encoding proteins, which promote bacterial fitness in a host environment, are expressed only when needed. Such regulation is in the purview of transcription factors, many of which belong to the ubiquitous multiple antibiotic resistance regulator (MarR) protein family. PecS proteins constitute a subset of this large protein family. PecS has likely been distributed by horizontal gene transfer, along with the divergently encoded efflux pump PecM, suggesting its integration into existing gene regulatory networks. Here, we discuss the …

Comparative Transcriptomic Analyses Reveal Differences In The Responses Of Diploid And Triploid Eastern Oysters To Environmental Stress, Rujuta V Vaidya, Sarah Bodenstein, Dildorakhon Rasulova, Jerome F La Peyre, Morgan W Kelly

Faculty Publications

Triploid oysters are commonly used as the basis for production in the aquaculture of eastern oysters along the USA East and Gulf of Mexico coasts. While they are valued for their rapid growth, incidents of triploid mortality during summer months have been well documented in eastern oysters, especially at low salinity sites. We compared global transcriptomic responses of diploid and triploid oysters bred from the same three maternal source populations at two different hatcheries and outplanted to a high (annual mean salinity = 19.4 ± 6.7) and low (annual mean salinity = 9.3 ± 5.0) salinity site. Oysters were sampled …

Macroevolution Of The Plant–Hummingbird Pollination System, Elisa Barreto, Mannfred M.A. Boehm, Ezgi Ogutcen, Stefan Abrahamczyk, Michael Kessler, Jordi Bascompte, Agnes S. Dellinger, Carolina Bello, D. Matthias Dehling, François Duchenne, Miriam Kaehler, Laura P. Lagomarsino, Lúcia G. Lohmann, María A. Maglianesi, Hélène Morlon, Nathan Muchhala, Juan Francisco Ornelas, Mathieu Perret, Nelson R. Salinas, Stacey D. Smith, Jana C. Vamosi, Isabela G. Varassin, Catherine H. Graham

Faculty Publications

Plant–hummingbird interactions are considered a classic example of coevolution, a process in which mutually dependent species influence each other's evolution. Plants depend on hummingbirds for pollination, whereas hummingbirds rely on nectar for food. As a step towards understanding coevolution, this review focuses on the macroevolutionary consequences of plant–hummingbird interactions, a relatively underexplored area in the current literature. We synthesize prior studies, illustrating the origins and dynamics of hummingbird pollination across different angiosperm clades previously pollinated by insects (mostly bees), bats, and passerine birds. In some cases, the crown age of hummingbirds pre-dates the plants they pollinate. In other cases, plant …

Bicarbonate Is A Key Regulator But Not A Substrate For O2 Evolution In Photosystem Ii, David J. Vinyard, Govindjee Govindjee

Faculty Publications

Photosystem II (PSII) uses light energy to oxidize water and to reduce plastoquinone in the photosynthetic electron transport chain. O2 is produced as a byproduct. While most members of the PSII research community agree that O2 originates from water molecules, alternative hypotheses involving bicarbonate persist in the literature. In this perspective, we provide an overview of the important roles of bicarbonate in regulating PSII activity and assembly. Further, we emphasize that biochemistry, spectroscopy, and structural biology experiments have all failed to detect bicarbonate near the active site of O2 evolution. While thermodynamic arguments for oxygen-centered bicarbonate oxidation are valid, the …

Louisiana Agriculture Magazine, Fall 2024

Louisiana Agriculture

Questions drive the science behind the LSU AgCenter. Researcher Erin Oberhaus wanted to find data to help educate Louisiana horse owners about the use of an important medication, and a water quality specialist wondered if noneconomic bodies of water, which include agricultural ponds, might help people generate electricity. The research projects that grew from their questions are detailed in this issue of Louisiana Agriculture.

Also in this issue, scientists share the results from important soybean studies, and the AgCenter farm to school team shares success stories from school gardens across the state.

Research is at the core of the LSU …

Monarch, Victoria Bourne (Editor)

Monarch Magazine

Fall 2024 issue of Monarch, the Old Dominion University Magazine.

Subtitled: Forward-Focused: ODU & EVMS Make History

2024 Fall Nutshell, Morehead State University. Institutional Research & Analysis.

Office of Institutional Research & Analysis Publication Archive

Fall 2024 issue of the Nutshell.

Development And Quantification Of An Attachment Assay For Epidermal Cells To Varying Extracellular Matrix Dilutions, Julian Vargas '26, Colleen L. Doçi

Annual Student Research Poster Session

The concept of cellular attachment is cells interacting with the extracellular matrices surrounding it. Extracellular matrices are made of various components, and it has been shown that the interactions differ between different classes of extracellular matrices. The basement membrane plays a critical role in the structure and function of the epidermis, the outermost layer of the skin. It is composed of key extracellular matrix components, which are crucial for structural stability of the skin and for maintaining the integrity of the epidermis. Through components like collagen, laminin, and proteoglycans, the BM facilitates communication between the epidermal cells and the connective …

Synthesis Of Drug-Like Molecules And Investigation Of Their Biological Activity, Duyen Nguyen '25, Sunny Nguyen '26, Jeffery A. Hansen

Annual Student Research Poster Session

This study examines the products derived from the ring-opening reactions of two novel epoxides—chlorobenzene epoxide and furan epoxide—highlighting their notable biological activity, particularly in the context of potential anticancer agents. One key finding: a synthesized stereoisomer of a hexylamine-derived β-amino alcohol exhibited a remarkably low LC50 value of 6.6 ppm in the Brine Shrimp Lethality Assay, significantly outperforming the other isomer compound’s LC50 value, at 13 ppm. This discovery underscores the critical role of stereochemistry in enhancing bioactivity, as evidenced by the distinct physical and chemical properties of the two hexylamine-derived isomers, including differences in appearance and solubility. Building on …

Inhibition Of Integrin Binding: Exploring Its Impact On Epidermal Cell Attachment, Erin R. Johnson '25, Colleen L. Doçi

Annual Student Research Poster Session

I worked with HaCaT cells, human epidermal cells that are sticky and like to attach to their surroundings in the skin. They have a surface protein called integrin, which interacts directly with collagen to induce cell attachment. I was particularly interested in interrupting this connection between integrin and collagen. I achieved this by using an inhibitory peptide that bound to the active site of integrin. This would allow me to calculate the cell attachment of HaCaT cells while in the presence of collagen. If we were able to target this treatment to tumor cells, we could help to stop them …