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Personality Dynamics Turn Positive And Negative Mood Into Creativity, Ronald Bledow, Jana Kuhnel, Julius Kuhl

Research Collection Lee Kong Chian School Of Business

Introduction: Research on the link between affect and creativity rests on the assumption that creativity unfolds as a stimulus-driven response to affective states. We challenge this assumption and examine whether personality dynamics moderate the relationship of positive and negative mood with creativity. Theoretical Model: According to our model, personality dynamics that generate and maintain positive affect and down-regulate negative affect energize creativity. Based on this model, we expect high creativity in response to negative mood if people engage in self-motivation and achieve a reduction in negative mood. We further derive that individual differences in action versus state orientation moderate the …

Bactericidal Mechanism Of Peracetic Acid Against Salmonella Mediated By Reactive Oxygen Species, Mohammed Khalid Wheib Al-Doury

Graduate Theses and Dissertations

Peracetic acid (PAA) is extensively used as a bactericidal agent in poultry processing to reduce foodborne pathogens, including Salmonella enterica serotype Typhimurium (S. Typhimurium). Despite its widespread application, the exact mechanisms underlying its bactericidal effects, particularly the role of reactive oxygen species (ROS), remain incompletely understood. This dissertation examines the role of ROS in PAA-mediated bacterial killing and explores both genetic and metabolic factors that influence bacterial susceptibility to PAA. Findings from these studies have implications for enhancing the efficacy of PAA, thereby improving food safety practices in the industry.

The first study investigates ROS as a central component …

Nonacademic Factors That Effect Early College High School Student's Resilency, Amy Draper

Electronic Theses and Dissertations

This qualitative descriptive study was an exploration of how counselors in early college high

schools (ECHSs), administrators in ECHSs, and the technical coaches who support the ECHS

model contribute to students’ resilience toward academic recovery. Using semistructured

interviews and survey questions, a sample of 15 counselors, administrators, and technical

coaches shared factors that impact ECHS recruiting practices, attrition rates, and the educational

success of individual ECHS students. Three themes were extracted from a sample of educators’

descriptions regarding their perception of the ECHS environment and the benefits and challenges

they experienced while working with ECHS students. They included the combined …

Foster Youth Experiencing Homelessness In Texas: An Analysis Of Risk And Protective Factors That Impact Housing Stability, Monique Willoughby

Electronic Theses and Dissertations

While research on youth homelessness continues to grow, not much is known about the differences that exist between states. To address specific concerns effectively, a more nuanced and granular approach to assessment is needed. Specifically, Texas youth who are transitioning from foster and other systems of care into young adulthood and more independent living will need tailored support to adequately address their needs. This study is a step in that direction. Through identification of risks factors that predict homelessness for these youth, social workers, counselors, case managers, and other human services providers and advocates can better assess, plan, and intervene …

Cellulose–Starch Composite Aerogels As Thermal Superinsulating Materials, Safoura Ahmadzadeh, Angelina Sagardui, David Huitink, Jingyi Chen, Ali Ubeyitogullari

Chemistry & Biochemistry Faculty Publications and Presentations

The demand for sustainable packaging materials is rapidly increasing due to growing environmental concerns over the impact of plastic waste. In this study, biodegradable, porous, lightweight, and high-surface-area microcrystalline cellulose–starch (MCC-S) hybrid aerogels were synthesized via supercritical carbon dioxide (SC–CO₂) drying. The samples were generated using five different MCC-S weight ratios and characterized for their morphology, crystallinity, and structural and thermal properties. When MCC and S were used together, aerogels with superior properties were obtained compared to those made from each component individually. Specifically, the 1:2 MCC-S aerogel exhibited the highest porosity (97%), the lowest density (0.058 g/cm …

Public Health Implications Of State-Level Public Health Organizational And System Structures, Cameron Ferguson Hays

Dissertations

Public health thought leaders such as the Institute of Medicine and National Academies of Science, Engineering, and Medicine have long been concerned about the lack of standardization among state-level public health systems (IOM, 1988; NASEM, 2023). However, little research studies these systems, their structures, and whether structural constructs affect population health outcomes.

This study attempted to examine the structural constructs that make up these systems and the impact of those constructs using an exploratory sequential mixed-methods design. Variables from management science were qualitatively extracted from materials describing all 50 state-level public health systems. Those variables were then analyzed using a …

Intelligent Health Monitoring Systems Via Flexible Hybrid Electronics And Machine Learning, Masoud Panahi

Dissertations

Advanced data analytics approaches, such as artificial intelligence (AI), are increasingly being integrated into all aspects of patient care. This integration is paving the way for minimally invasive or non-invasive treatment modalities. By combining recent advancements in fabrication technology and computing ingenuity, wearable devices now enable continuous health monitoring and provide data for AI-driven analysis. These intelligent devices seamlessly integrate with the Internet of Things (IoT), enabling remote or “at-home” patient monitoring.

This dissertation study investigates the integration of recent advancements in flexible hybrid electronics (FHE) and machine learning (ML) to develop intelligent health monitoring systems. The developed FHE-based health …

Real-Time Motion Augmentation And Synthesis For Animating The Hands And Eyes Of Virtual Humans And Avatars, Ryan Canales

All Dissertations

Virtual Reality (VR) enables users to interact within virtual worlds via an embodied virtual representation of themselves called an “avatar”. Because avatars are essential for immersive experiences, it is important to consider how altering or augmenting avatar motion affects virtual experiences. This dissertation aims to improve virtual experiences by addressing some of the many challenges in animating avatars and virtual humans.

In our first study, we addressed the lack of tactile feedback during virtual grasping by using visual feedback techniques. We augmented the avatar’s hand motion to remain outside virtual objects (“outer hand”) even when the user’s hand penetrated them. …

Sufex-Enabled Stereospecific Deoxygenative Diversification Of Alcohols, Amaechi Odoh

All Dissertations

Alcohols represent an important class of functional group in organic synthesis and medicinal chemistry, given that they are structurally diverse and prevalent in many natural products, biomolecules and renewable feedstocks. As such, they are highly attractive precursors for building-block synthesis, late-stage functionalization, and numerous synthetic transformations. However, existing strategies for the deoxygenative diversification of alcohols operate under constrained conditions, often leading to competing pathways (such as elimination), poor stereospecificity, low efficiencies, and limited substrate compatibility. To address these challenges, we have developed a conceptually novel use of sulfonyl fluorides as bifunctional reagents for the one-step deoxygenative diversification of complex alcohol …

Deformation Mechanism In Gold Nanoparticles Under Compressive Loading: Insights From Atomistic Modelling And Unsupervised Machine Learning, Tanuj Gupta

All Dissertations

Gold nanoparticles (AuNPs) offer exciting possibilities due to their inertness, malleability, and tunable structures, making them valuable for applications ranging from nanomedicine to electronics. Their optical, mechanical, and other properties can be tailored by modifying shape and structure, underscoring the importance of understanding their deformation behaviour at the nanoscale. This study used classical molecular dynamics simulations with LAMMPS to investigate the deformation mechanisms of gold nanospheres (AuNS) under uniaxial compression. Employing the embedded atom method (EAM) potential to model atomic interactions, AuNS with 20 nm in diameter were compressed along the z-direction using planar indenters moving at a constant …

The Clot Thickens: Investigation Of The Mechanism Behind Hypercoagulation In Covid-19 Patients, Toni Warnick

All Dissertations

Since its emergence in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with cardiovascular complications, which correlate with illness severity and increased mortality. It was initially thought that this hypercoagulable state was induced by endothelial dysfunction or cytokine storm because of SARS-CoV-2 infection. Although platelets have been reported to express the SARS-CoV-2 primary target receptor, angiotensin-converting enzyme 2 (ACE2), this remains controversial due to conflicting findings that suggest minimal to no ACE2 expression on platelets. This ambiguity has led to exploring alternative entry pathways, notably via the virus’s RGD (arginine-glycine-aspartic acid) sequence within its spike protein receptor-binding …

Heavy Metals In Rural Soils: A Case Study In Jennings County, Indiana, Madeline Hill

All-Inclusive List of Electronic Theses and Dissertations

Heavy metals, such as lead and mercury, can be toxic if exposure levels are too high. People are often concerned about lead exposure from water or paint, but soil is another potential exposure avenue for many metals. While some heavy metals, including mercury and lead, are found in emissions from coal-burning power plants and from incinerators, many metals accumulate in soils from past uses (ex. lead paint, leaded gasoline, chemical spills, industrial emissions, and natural occurrences). It is important to have soil tested to check metal concentrations because consumption or inhalation of these metals can lead to permanent damage and …

Size Matters: The Characterization Of Telomere Function In Germ Cell Development In Danio Rerio, Jessica Macneil

Graduate Doctoral Dissertations

Infertility is a growing problem worldwide. According to the WHO, 48 million couples across the globe suffer from infertility and many couples turn to Assisted Reproductive Technology (ART) to become pregnant. One readout of gamete quality and successful ART is telomere integrity because telomeres are necessary for chromosome movements during meiosis so that the segregation of chromosomes happens correctly. Telomeres are well known for their role in aging; however, they play an important and understudied role during meiosis. In meiosis, telomeres attach to the nuclear envelope (NE) via a protein chain spanning the NE that interacts with cytoplasmic motor proteins, …

Modeling Impact Of Simulated Myocardial Perfusion On Cardiac Ablation For Arrhythmia, Brendan Cappon

Theses

Bioheat transfer is the study of heat transfer applied in anatomy and physiology, which is relevant to maintaining homeostatic conditions from metabolic activity, thermal exposures, and various treatments and diagnostic methods. Blood flow significantly impacts heat transfer throughout the body, facilitating the diffusion of heat. Models have been developed to quantify bioheat transfer and the effect of blood flow through tissue for many biological functions and medical procedures, one of which is radiofrequency ablation for cardiac arrhythmia. Significant improvements to models and assumptions are still required as success rates for this procedure remain low for various arrhythmia types. The research …

Waste Recycling Strategy And Its Role In Enhancing The Dimensions Of Sustainable Development In Iraq, Mustafa H. Kzar, Hamdia Shaker Moslem

Journal of Economics and Administrative Sciences

Purpose: The aim of this study was to determine the importance of waste recycling in addressing economic, social and environmental problems facing most countries of the world, especially developing countries, including Iraq, Where Iraq has not developed a recycling strategy for waste considering the economic and climatic changes that the world is witnessing with the increase in population growth rates and the expansion of cities. Theoretical Framework: Many economists, such as (Kirrchher J., & et al., 2017; Murray, A., & et al., 2015; Prieto-Sandoval V. & et al., 2018; Williams, 2013) have also highlighted the importance of practices in production …

The Impact Of E-Commerce On Digital Marketing Hopes And Ambitions: A Case Study In Airline Reservation Offices In Iraq, Anas Maaroof, Abdullah Oğrak

Journal of Economics and Administrative Sciences

Purpose: The current study aims to identify the impact of e-commerce with digital marketing in airline reservation offices in the Republic of Iraq. The study consists of two main variables: the independent variable that included e-commerce, which consisted of four dimensions: Business-to-Business, Consumer-to-Business, and Consumer-to. - Consumer, Business-to-Government, and the dependent variable represents digital marketing, the dimensions of which are: website design, social media marketing, search engine optimization, and email marketing. Theoretical Framework: Upon on Maaroof, A. (2021) This study highlights the importance of e-commerce and digital marketing, such as booking corners during digital transactions in airline reservation offices, as …

Alternative Agrifood Systems And The Economic Sustainability Of Farmers' Cooperatives: The Chinese Experience, Zhanping Hu, Qian Forrest Zhang

Research Collection School of Social Sciences

Most registered farmers' cooperatives in China are de facto private enterprises; while many bring economic gains to farmers, they do not function as cooperatives. Among the small minority that started as authentic cooperatives, however, most struggled to provide economic benefits to members, unable to achieve economic sustainability. The failure of true farmers' cooperatives in China has been widely studied; the success of the few that did become economically sustainable, however, remains poorly understood. Using a sample of 70 farmers' cooperatives across the country and comparing three “extreme cases”—cooperatives that are both authentic and economically successful—with the rest, this study argues …

The Effects Of Casein Glycomacropeptide On General Health Status In Children With Pku: A Randomized Crossover Trial, Alex Pinto, Anne Daly, Camille Newby, Abigail Robotham, Simon Heales, Simon Eaton, Helen Aitkenhead, Kimberly Gilmour, Richard Jackson, Catherine Ashmore, Sharon Evans, Júlio Cesar Rocha, Fatma Ilgaz, Mary Hickson, Anita Macdonald

School of Health Professions

In PKU, it is suggested that casein glycomacropeptide based protein substitute (GMP) may have physiological advantage when satiety, oxidative stress, renal function and inflammation are considered. Its prebiotic properties may also help gastrointestinal (GI) tolerance. In children with PKU, a randomized/crossover trial comparing phenylalanine-free amino acids (AA) vs GMP as the single source of protein substitute for 12-weeks in each arm was conducted. There was a 4-week wash out period with AA in-between. At baseline and end of each intervention, blood and fecal samples were taken to monitor gut health, oxidative stress, renal function, inflammatory markers and plasma amino acids. …

The Rage, Fall 2024, Aspen Humphries, Savannah Moore, Lottie Taylor

The Rage Zine

The Rage zine is published in collaboration with Students Advocating Gender Equality and CCU Women's and Gender Studies. Volume 3, Issue 1.

Subcutaneous Ocrelizumab In Multiple Sclerosis: Results Of The Phase 1b Ocarina I Study, Scott D Newsome, Robert T Naismith, Et Al.

2020-Current year OA Pubs

OBJECTIVE: Subcutaneous ocrelizumab is being developed to provide treatment flexibility and additional choice to patients with multiple sclerosis. OCARINA I (NCT03972306) is an open-label, multicenter, Phase 1b, dose-finding study to investigate the pharmacokinetics, safety, tolerability, and immunogenicity of subcutaneous ocrelizumab and to select a dose for the Phase 3 OCARINA II study (NCT05232825).

METHODS: Patients with relapsing or primary progressive multiple sclerosis (aged 18-65 years; Expanded Disability Status Scale score 0.0-6.5) were enrolled into two groups: previously treated with intravenous ocrelizumab (Group A) or naïve to ocrelizumab (Group B). Patients received single ascending doses of subcutaneous ocrelizumab up to 1200 …

Prevalence, Diagnostic Features, And Medical Outcomes Of Females With Turner Syndrome With A Trisomy X Cell Line (45, X/47, Xxx): Results From The Insights Registry, Natalia Klamut, Samantha Bothwell, Alexandra E Carl, Vaneeta Bamba, Jennifer R Law, Wendy J Brickman, Karen O Klein, Roopa Kanakatti Shankar, Catherina T Pinnaro, Patricia Y Fechner, Siddharth K Prakash, Iris Gutmark-Little, Susan Howell, Nicole Tartaglia, Marybel Good, Kelly C Ranallo, Shanlee M Davis

Faculty, Staff and Student Publications

Turner syndrome (TS) is defined by partial or complete absence of a sex chromosome. Little is known about the phenotype of individuals with TS mosaic with trisomy X (45,X/47,XXX or 45,X/46,XX/47,XXX) (~3% of TS). We compared the diagnostic, perinatal, medical, and neurodevelopmental comorbidities of mosaic 45,X/47,XXX (n = 35, 9.4%) with nonmosaic 45,X (n = 142) and mosaic 45,X/46,XX (n = 66). Females with 45,X/47,XXX had fewer neonatal concerns and lower prevalence of several TS-related diagnoses compared with 45,X; however the prevalence of neurodevelopmental and psychiatric diagnoses were not different. Compared to females with 45,X/46,XX, the 45,X/47,XXX group was significantly …

The Prognostic Impact Of Tumor Deposits In Colorectal Cancer: More Than Just N1c, Neal Bhutiani, Oliver Peacock, Abhineet Uppal, Chung-Yuan Hu, Brian K Bednarski, Melissa W Taggart, Arvind Dasari, Van K Morris, Harmeet Kaur, Scott Kopetz, Emma B Holliday, Prajnan Das, Y Nancy You, George J Chang

Faculty, Staff and Student Publications

Background: The identification of tumor deposits (TD) currently plays a limited role in staging for colorectal cancer (CRC) aside from N1c lymph node designation. The objective of this study was to determine the prognostic impact, beyond American Joint Committee on Cancer N1c designation, of TDs among patients with primary CRC.

Methods: Patients who had resected stage I-III primary CRC diagnosed between 2010 and 2019 were identified from the National Cancer Institute's Surveillance, Epidemiology, and End Results database. Cancer-specific survival (CSS) stratified by TD status and lymph node (N) status was calculated using the Kaplan-Meier method and multivariable Cox proportional hazards …

Mimosa: A Resource Consisting Of Improved Methylome Prediction Models Increases Power To Identify Dna Methylation-Phenotype Associations, Hunter J Melton, Zichen Zhang, Hong-Wen Deng, Lang Wu, Chong Wu

Faculty, Staff and Student Publications

Although DNA methylation (DNAm) has been implicated in the pathogenesis of numerous complex diseases, from cancer to cardiovascular disease to autoimmune disease, the exact methylation sites that play key roles in these processes remain elusive. One strategy to identify putative causal CpG sites and enhance disease etiology understanding is to conduct methylome-wide association studies (MWASs), in which predicted DNA methylation that is associated with complex diseases can be identified. However, current MWAS models are primarily trained using the data from single studies, thereby limiting the methylation prediction accuracy and the power of subsequent association studies. Here, we introduce a new …

Precision And Efficacy Of Rna-Guided Dna Integration In High-Expressing Muscle Loci, Made Harumi Padmaswari, Gabrielle Bulliard, Shilpi Agrawal, Mary S. Jia, Sabin Khadgi, Kevin A. Murach, Christopher E. Nelson

Biomedical Engineering Faculty Publications and Presentations

Gene replacement therapies primarily rely on adeno-associated virus (AAV) vectors for transgene expression. However, episomal expression can decline over time due to vector loss or epigenetic silencing. CRISPR-based integration methods offer promise for long-term transgene insertion. While the development of transgene integration methods has made substantial progress, identifying optimal insertion loci remains challenging. Skeletal muscle is a promising tissue for gene replacement owing to low invasiveness of intramuscular injections, relative proportion of body mass, the multinucleated nature of muscle, and the potential for reduced adverse effects. Leveraging endogenous promoters in skeletal muscle, we evaluated two highly expressing loci using homology-independent …

Off-Protocol Radiation Therapy In Phase 3 Metastatic Solid Tumor Trials, Alexander D Sherry, Timothy A Lin, Zachary R Mccaw, Esther J Beck, Ramez Kouzy, Joseph Abi Jaoude, Adina H Passy, Avital M Miller, Gabrielle S Kupferman, Clifton David Fuller, Charles R Thomas, Eugene J Koay, Chad Tang, Pavlos Msaouel, Ethan B Ludmir

Faculty, Staff and Student Publications

Purpose: Increasing data suggest that radiation therapy, particularly ablative radiation therapy, alters the natural history of metastatic disease. For patients with metastatic disease enrolled in prospective trials testing systemic therapy, the use of off-protocol radiation therapy to improve clinical symptoms or extend the duration of study systemic therapy may influence study endpoints. We sought to evaluate how often off-protocol radiation therapy was permitted among systemic therapy phase 3 trials, how often off-protocol radiation therapy is used, and whether off-protocol radiation therapy correlated with study outcomes.

Methods and materials: Two-arm, superiority-design, phase 3 randomized trials testing systemic therapy were screened from …

Contemporary Approach To The Diagnosis And Classification Of Myelodysplastic Neoplasms/Syndromes-Recommendations From The International Consortium For Myelodysplastic Neoplasms/Syndromes (Mds [Icmds]), Fnu Aakash, Savanah D Gisriel, Amer M Zeidan, John M Bennett, Rafael Bejar, Jan Philipp Bewersdorf, Uma M Borate, Jacqueline Boultwood, Andrew M Brunner, Rena Buckstein, Hetty E Carraway, Jane E Churpek, Naval G Daver, Amy E Dezern, Fabio Efficace, Pierre Fenaux, Maria E Figueroa, Guillermo Garcia-Manero, Steven D Gore, Peter L Greenberg, Elizabeth A Griffiths, Stephanie Halene, Christopher S Hourigan, Tae Kon Kim, Nina Kim, Rami S Komrokji, Vijay K Kutchroo, Alan F List, Richard F Little, Ravindra Majeti, Aziz Nazha, Stephen D Nimer, Olatoyosi Odenike, Eric Padron, Mrinal M Patnaik, Uwe Platzbecker, Matteo G Della Porta, Gail J Roboz, David A Sallman, Valeria Santini, Guillermo Sanz, Michael R Savona, Mikkael A Sekeres, Maximilian Stahl, Daniel T Starczynowski, David P Steensma, Justin Taylor, Omar Abdel-Wahab, Andrew H Wei, Zhuoer Xie, Mina L Xu, Robert P Hasserjian, Sanam Loghavi

Faculty, Staff and Student Publications

Myelodysplastic neoplasms/syndromes (MDS) are a heterogeneous group of biologically distinct entities characterized by variable degrees of ineffective hematopoiesis. Recently, 2 classification systems (the 5th edition of the World Health Organization Classification of Haematolymphoid tTumours and the International Consensus Classification) further subcharacterized MDS into morphologically and genetically defined groups. Accurate diagnosis and subclassification of MDS require a multistep systemic approach. The International Consortium for MDS (icMDS) summarizes a contemporary, practical, and multimodal approach to MDS diagnosis and classification.

Body Composition In Recurrent Prostate Cancer And The Role Of Steroidogenic Genotype, Neha Venkatesh, Rebecca S Tidwell, Yao Yu, Ana Aparicio, Amado J Zurita, Sumit K Subudhi, Bilal A Siddiqui, Sagar S Mukhida, Justin R Gregg, Paul G Corn, Efstratios Koutroumpakis, Jennifer L Mcquade, Daniel E Frigo, Patrick G Pilie, Chad Huff, Christopher J Logothetis, Andrew W Hahn

Faculty, Staff and Student Publications

Hormone therapy (HT) to treat prostate cancer is reported to cause adverse changes in body composition. Clinically, interpatient body composition changes are heterogeneous, but the biological and clinical determinants of body composition toxicity are unknown. Herein, we test the hypothesis that inherited polymorphisms in steroidogenic genes are associated with differential changes in body composition after HT. Men with biochemically recurrent prostate cancer (BCR) who received 8 months of LHRH analog (LHRHa) +/- abiraterone acetate (AAP) were eligible if they had: i) CT imaging of L3 prior to and after treatment; and ii) nucleated cells collected. Cardiometabolic co-morbidities were retrospectively extracted. …

The Relationship Between Salvinia Molesta Infestation And The Microbial Ecology Of Wetlands At Caddo Lake, Tx, Usa, Martin Hadsell

Electronic Theses and Dissertations

Wetlands are known to host many beneficial geochemical processes such as nutrient cycling and carbon sequestration. These processes are primarily driven by the microbial communities within a wetland. The establishment of non-native invasive species within wetlands has the potential to alter the once beneficial functionality of wetland microbial communities due to the sensitivity microbes have towards environmental changes. Because of this, several metagenomic studies have been conducted to assess microbial community response to aquatic plant invasion; however, there haven’t been any studies researching the influence of Salvinia molesta (D.S. Mitch.), commonly known as Giant Salvinia, on microbial communities. The goal …

Bioremediation Of Effluent Water In A Coal Ash Disposal Area: Optimizing Microbial Sulfate Reduction, Ryka Shea

Electronic Theses and Dissertations

Coal combustion residues (CCR) pose a serious environmental threat, even long after they are disposed of in specialized landfills, due to their complex composition and potential for leaching into waterways. This study focuses on the issue of elevated sulfate concentrations at the Martin Lake Steam Electric Station (MLSES) A-I Disposal Area in Panola County, Texas, where CCR are disposed of in a permanent landfill. Currently, this site is exceeding its regulatory limit of sulfate concentrations in its effluent and is in need of a cost-effective and sustainable solution to this problem. This research utilized benchtop experiments to investigate sulfate reducing …

Inflammation, Physical Activity, And Disease-Free Survival In Stage Iii Colon Cancer: Cancer And Leukemia Group B-Southwest Oncology Group 80702 (Alliance), Justin C Brown, Chao Ma, Qian Shi, Felix Couture, Philip Kuebler, Pankaj Kumar, Benjamin Tan, Smitha Krishnamurthi, Victor Chang, Richard M Goldberg, Eileen M O'Reilly, Anthony F Shields, Jeffrey A Meyerhardt

2020-Current year OA Pubs

BACKGROUND: Inflammation and insufficient physical inactivity contribute to individual-level risk of disease recurrence and death in stage III colon cancer. The extent to which increased inflammatory risk can be offset by sufficient physical activity remains unknown.

METHODS: This cohort study was nested within the Cancer and Leukemia Group B (now part of the Alliance for Clinical Trials in Oncology) and Southwest Oncology Group randomized trial. Inflammatory burden was quantified by high-sensitivity C-reactive protein, interleukin-6, and soluble tumor necrosis factor-α receptor 2 after recovery from tumor resection. Physical activity was measured during and after postoperative chemotherapy. The primary endpoint was disease-free …