Digital Commons Network^™

Dna Mismatch Repair Deficiency As A Biomarker In Sarcoma, Ryan A Denu, Christopher D Quintana-Perez, Sintawat Wangsiricharoen, Davis R Ingram, Khalida M Wani, Alexander J Lazar, Ravin Ratan, Christina L Roland, Y Nancy You

Faculty, Staff and Student Publications

Purpose: Lynch syndrome (LS) is a cancer predisposition syndrome caused by a germline loss-of-function mutation in a mismatch repair (MMR) gene. While sarcomas are not classically considered LS cancers, we investigated the MMR status and clinical features of sarcomas in LS patients to help inform optimal treatment strategies.

Methods: A prospectively maintained institutional clinical cancer genetics database was queried for LS patients (defined by pathogenic germline mutation in a MMR gene) with a documented diagnosis of sarcoma between 1998-2022. Tumor MMR status was determined by immunohistochemistry (IHC) for MMR proteins and secondarily by PCR assay if IHC was normal or …

Ras-Mutant Leukaemia Stem Cells Drive Clinical Resistance To Venetoclax, Junya Sango, Saul Carcamo, Maria Sirenko, Abhishek Maiti, Hager Mansour, Gulay Ulukaya, Lewis E Tomalin, Nataly Cruz-Rodriguez, Tiansu Wang, Malgorzata Olszewska, Emmanuel Olivier, Manon Jaud, Bettina Nadorp, Benjamin Kroger, Feng Hu, Lewis Silverman, Stephen S Chung, Elvin Wagenblast, Ronan Chaligne, Ann-Kathrin Eisfeld, Deniz Demircioglu, Dan A Landau, Piro Lito, Elli Papaemmanuil, Courtney D Dinardo, Dan Hasson, Marina Konopleva, Eirini P Papapetrou

Faculty, Staff and Student Publications

Cancer driver mutations often show distinct temporal acquisition patterns, but the biological basis for this, if any, remains unknown. RAS mutations occur invariably late in the course of acute myeloid leukaemia, upon progression or relapsed/refractory disease1-6. Here, by using human leukaemogenesis models, we first show that RAS mutations are obligatory late events that need to succeed earlier cooperating mutations. We provide the mechanistic explanation for this in a requirement for mutant RAS to specifically transform committed progenitors of the myelomonocytic lineage (granulocyte-monocyte progenitors) harbouring previously acquired driver mutations, showing that advanced leukaemic clones can originate from a different cell type …

Psychophysical And Functional Outcomes In Chemotherapy-Induced Peripheral Neuropathy After Spinal Cord Stimulation: A Narrative Review And Case Series, Peter D Vu, Kathleen Erin Mcdonough, Patrick M Dougherty, Ryan S D'Souza, Saba Javed

Faculty, Staff and Student Publications

Objectives: Chemotherapy-induced peripheral neuropathy (CIPN) is a complication that may occur after treatment with various anticancer drugs. In refractory CIPN cases, spinal cord stimulation (SCS) has garnered increased attention. The use of gait analysis and psychophysical quantitative sensory testing (QST) as an objective measurement of CIPN-related damage has burgeoned; however, these changes have not been reported for patients with CIPN after SCS implantation using either burst or tonic stimulation.

Materials and methods: This manuscript encompasses two parts: 1) a presentation of pain improvement in a series of patients who underwent tonic vs burst SCS for CIPN measured by gait and …

Explainable Artificial Intelligence And Domain Adaptation For Predicting Hiv Infection With Graph Neural Networks, Evan Yu, Jingcheng Du, Yang Xiang, Xinyue Hu, Jingna Feng, Xi Luo, John A Schneider, Degui Zhi, Kayo Fujimoto, Cui Tao

Faculty, Staff and Student Publications

OBJECTIVE: Investigation of explainable deep learning methods for graph neural networks to predict HIV infections with social network information and performing domain adaptation to evaluate model transferability across different datasets.

METHODS: Network data from two cohorts of younger sexual minority men (SMM) from two U.S. cities (Chicago, IL, and Houston, TX) were collected between 2014 and 2016. Feature importance from graph attention network (GAT) models were determined using GNNExplainer. Domain adaptation was performed to examine model transferability from one city dataset to the other dataset, training with 100% of the source dataset with 30% of the target dataset and prediction …

Assessment Of Gender Differences In Letters Of Recommendation For Physical Therapy Residency Applications, Darren Q Calley, Sunyang Fu, Marissa D Hamilton, Austin W Kalla, Christopher K Lee, Veronica A Rasmussen, John H Hollman, Hongfang Liu

Faculty, Staff and Student Publications

Introduction: Letters of recommendation (LOR) are an integral component of physical therapy residency applications. Identifying the influence of applicant and writer gender in LOR will help identify whether potential implicit gender bias exists in physical therapy residency application processes.

Review of literature: Several medical and surgical residency education programs have reported positive, neutral, or negative LOR female gender bias among applicants and writers. Little research exists on gender differences in LOR to physical therapy education programs or physical therapy residency programs.

Subjects: Seven hundred sixty-eight LOR were analyzed from 256 applications to 3 physical therapy residency programs (neurologic, orthopaedic, sports) …

Imipridones Inhibit Tumor Growth And Improve Survival In An Orthotopic Liver Metastasis Mouse Model Of Human Uveal Melanoma, Chandrani Chattopadhyay, Janos Roszik, Rajat Bhattacharya, Md Alauddin, Iqbal Mahmud, Sirisha Yadugiri, Mir Mustafa Ali, Fatima S Khan, Varun Vijay Prabhu, Philip L Lorenzi, Bo Wei, Elizabeth Burton, Rohini R Morey, Rossana Lazcano, Michael A Davies, Sapna P Patel, Elizabeth A Grimm

Faculty, Staff and Student Publications

Background: Uveal melanoma (UM) is a highly aggressive disease with very few treatment options. We previously demonstrated that mUM is characterized by high oxidative phosphorylation (OXPHOS). Here we tested the anti-tumor, signaling and metabolic effects of imipridones, which are CLPP activators, which inhibit OXPHOS indirectly and have demonstrated safety in patients.

Methods: We assessed CLPP expression in UM patient samples. We tested the effects of imipridones (ONC201 and ONC212) on the growth, survival, signaling and metabolism of UM cell lines in vitro, and for therapeutic efficacy in vivo in UM liver metastasis models.

Results: CLPP expression was detected in primary …

Issue 41

The Synapse: Intercollegiate science magazine

No abstract provided.

The Care Crisis: The Neurology Of Dementia And International Solutions, Sophie Paton

The Synapse: Intercollegiate science magazine

No abstract provided.

Will My Celsius Addiction Kill Me?: The Thermogenic Drink And Its Impact On Nutrition And Metabolism, Katie Johnstone

The Synapse: Intercollegiate science magazine

No abstract provided.

Civil Liability And Intra-Fraternal, Sexually Predatory Behavior, Gregory S. Parks, Ryan W. Mckee

SMU Law Review Forum

Sexually predatory behavior has long been an issue within many institutions and organizations. The Catholic Church has been scrutinized for the involvement of Popes, priests, nuns, and others as perpetrators and enablers of child sexual abuse. Reports of child sexual abuse dating back as far as the 1940s have plagued the Catholic Church in both the US and Europe, with estimates in the US across all dioceses suggesting over four thousand priest/deacon perpetrators and over ten thousand victims affected between the 1950s and 2002. Similarly, sexual abuse has been an issue in the Boy Scouts of America, dating back to …

Exploring Variably Saturated Flow Formulations For Modflow: Implementing A Fully 3d Richards' Equation In Modflow 6, Sebastian Vazquez-Gasty

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

This thesis explores the implementation of a fully 3D Richards’ equation solution into MODFLOW 6 to solve for saturated/unsaturated flow. Currently, MODFLOW 6 has limited capability for solving unsaturated zone flow problems by using the Unsaturated Zone Flow (UZF) package, which neglects capillarity and assumes vertical 1-dimensional flow. Various formulations of the Richards’ equation were first evaluated for their strengths and weaknesses. Various numerical solution approaches to Richards’ equation were also studied to understand the robustness and efficiency of different approaches and to select one that would best fit into the MODFLOW 6 framework. The MODFLOW 6 framework was also …

Argument Schema Of Undergraduate Engineering Students, Anu Singh

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Critical thinking is one of the most desired skills in the workplace, as it assists an individual in solving complex problems and making informed decisions, resulting in their workplace success. Argumentation is one instructional approach that provides students an opportunity to engage in higher-order thinking and improve their communication skills. Argumentative writing provides opportunities to engage in multiple perspectives of a problem, provide evidence for the claim, evaluate evidence, engage in reasoning, and acknowledge self-bias, which automatically engages students in critical thinking. Previous literature has shown that despite the use of interventions and scaffolding approaches, students' argumentative texts lack elements …

Increasing The Impact Of Dietary Fiber From Grains On Human Health Through Gut Microbiome, Sujun Liu

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The relationship between dietary fiber intake and human health has gained significant attention due to its potential in preventing chronic diseases and promoting gut health. Grains are a primary source of dietary fiber; however, the health impact of grain fibers is often limited because they are incompletely metabolized by gut bacteria. This dissertation explores innovative strategies to enhance the concentration and of dietary fiber from grains and its utilization by gut bacteria. By investigating various treatments, this research aims to maximize the health benefits of grain-derived dietary fibers, thereby contributing to a healthier society.

This dissertation is organized into four …

Survival And Occupancy Of Red-Bellied Woodpeckers In A Fragmented Forested Landscape In North-Central Ohio, 1995-2005, David A. Zuwerink, James S. Marshall

North American Bird Bander

No abstract provided.

Recent Literature, Claire Stuyck

North American Bird Bander

No abstract provided.

A New Angle On Using Mist-Nets To Capture Wintering Grassland Birds, John A. Muller, Erin H. Strasser, Nuwanthika Nagode, Jeremy D. Ross

North American Bird Bander

No abstract provided.

A Summary Of The Nabb Survey Results, Michael Bishop

North American Bird Bander

No abstract provided.

2024 Atlantic Flyway Review (Spring Migration), Aaron Given

North American Bird Bander

No abstract provided.

Summary Of The 2024 Western Bird Banding Associastion Annual Meeting, Danielle Kaschube

North American Bird Bander

No abstract provided.

Inaugural Caribbean Flyway Review, Daniele Ventura Del Puerto, E. A. Buckmire

North American Bird Bander

No abstract provided.

Biological Reinforcement Learning Simulation For Natural Enemy -Host Behavior: Exploring Deep Learning Algorithms For Population Dynamics, Komi Mensah Agboka, Emmanuel Peter, Erion Bwambale, Bonoukpoè Mawuko Sokame

All Peer-Reviewed Publications

This study introduces a simulation of biological reinforcement learning to explore the behavior of natural enemies in the presence of host pests, aiming to analyze the population dynamics between natural enemies and insect pests within an ecological context. The simulation leverages on Q-learning, a reinforcement learning algorithm, to model the decision-making processes of both parasitoids/predators and pests, thereby assessing the impact of varying parasitism and predation rates on pest population growth. Simulation parameters, such as episode count, duration in months, steps, learning rate, and discount factor, were set arbitrarily. Environmental and reward matrices, representing climatic conditions, crop availability, and the …

A Phenomenographic Analysis Of Undergraduate Student Perceptions Of The Geosciences And Geoscience Careers, Leah M. Wiitablake

All Dissertations

The climate crisis is upon us, whether we like it or not, and its undeniable effects are evident. Take, for example, Hurricane Helene, which caused unimaginable devastation to what was once considered a “climate haven,” Asheville, NC (Andreoni, 2024; Medina & Fausset, 2024). Hurricane Helene made landfall as a Category 4, jumping from a Category 1 in less than 24 hours (Andreoni, 2024), and is noted by the National Hurricane Center as a major hurricane (National Hurricane Center & Central Pacific Hurricane Center, 2024). With the Earth now unlikely to remain below 1.5°C of warming (IPCC, 2023b), perhaps we can …

Socio-Ecological Drivers Of Anthropogenic Marine Debris Effects On Coral Reef Communities In The Florida Keys, Usa, Tokea Payton

All Dissertations

The Florida Keys reef tract has rapidly shifted from a structurally complex, hard coral-dominated reef to a less rugose, soft coral-dominated reef. Persistent anthropogenic stressors facilitate ecological transitions by including recreational and commercial fishing and increased anthropogenic marine debris. These artificial structures are becoming habitats for small marine taxa known as cryptofauna. Cryptofauna are among the most essential yet understudied reef taxa where little is known about their fate considering degrading coral reefs and increasing anthropogenic disturbance. With increased anthropogenic stressors on the marine environment, the SCUBA diving community has initiated extensive marine debris removal efforts to assist in cleaning …

Disability, Sense Of Belonging, And Inclusive Classroom Climates In Undergraduate Engineering, Candice W. Bolding

All Dissertations

In higher education, there has been a growing interest in identifying and addressing the systemic factors that impact the educational experiences and outcomes of underrepresented students pursuing degrees in engineering. Students who identify as having one or more disabilities are an underrepresented population in postsecondary engineering, and although this population of students possess numerous strengths that make them well suited for the field, they often face barriers and challenges that hinder their success within engineering programs. There exists a robust collection of literature examining the experiences and factors that impact other underrepresented groups within postsecondary engineering (e.g., students of color …

Understanding Support For Former Foster Youth: Independent Living Coordinators Perspectives On Resiliency For Foster Youth In Higher Education, Aaron Abbott

Graduate Theses and Dissertations

This dissertation examines the resilience of former foster youth in higher education, focusing on the perspectives of Independent Living Coordinators (ILCs) in Arkansas. The study explores the support systems and challenges that foster youth encounter, assessing factors that contribute to or hinder their educational success. Using a qualitative methodology with semi-structured interviews, it identifies key protective factors such as emotional support, stable mentorship, and institutional programs that promote resilience among foster youth. The findings suggest that tailored interventions and a strengths-based approach can significantly improve outcomes for this vulnerable student population. This research contributes to existing literature by offering insights …

Perceptions Of School Readiness Through The Lens Of Sel, Lisa Goncalves

Seton Hall University Dissertations and Theses (ETDs)

School readiness includes a range of competencies and is influenced by both parental beliefs and teacher perceptions. Despite its significance, only a small number of states have an established definition of school readiness, which raises questions about how well stakeholder understandings align and the effectiveness of parental activities in promoting school readiness. In New Jersey, significant investments are being made to expand early educational opportunities, emphasizing the critical nature of this topic. With no standardized definition of school readiness and given the gaps in existing research, it is essential to explore the alignment between parent and teacher perceptions of school …

Kinship Verification Based On Intelligent Techniques: Survey, Muna Ghazi Abdulsahib

Iraqi Journal of Computers, Communications, Control and Systems Engineering

Kinship verification is the process of using observable characteristics, including facial features or other biometric data, to ascertain whether two people are familial related. Current approaches to kinship verification encounter multiple challenges, despite their significance in fields such as biometric security, family reunification, and forensic investigations. The most accurate way to confirm kinship is by DNA analysis, which is expensive, time-consuming, and invasive; in contrast, the traditional methods using manual comparison and facial recognition are more prone to human mistake. Visual verification of kinship among family members can be difficult to reliably rely on due to genetic variability, aging, and …

Blend Matters: Interactions Of Rice Cultivars On Milling, Physico-Chemical & End Use Traits, Bindu Regonda

Graduate Theses and Dissertations

Rice blending or mixing of different rice cultivars, a common practice in the industry, significantly impacts processing efficiency and end-product quality, yet its effects on end products remain understudied. This research investigated the implications of blending contemporary Arkansas rice cultivars through two comprehensive studies focusing on milling yields and physicochemical properties, instantization, and parboiling processes. Five long-grain cultivars, including hybrids (RT 7521 FP, RT 7321 FP, XP 753) and purelines (Ozark, CLL 16), were blended in various combinations and different drying.

The first study revealed that blending significantly affected milling yields and physicochemical attributes. Pre-drying blending yielded better results compared …

Quantifying Greenhouse Gas Exchange And Ecosystem Services In Ecosystems Managed For Nature-Based Solutions Using Eddy Covariance, Remote Sensing, And Models, Lucas Clay

All Dissertations

As global temperatures rise due to climate change, nature-based solutions are increasingly being used to restore nature and to remove carbon from the atmosphere. Nature-based solutions draw on methodologies such as ecological forestry and improved forest management to reduce emissions and maximize resilience. These protocols are still in their infancy and additional measurements and case studies are important to optimizing these protocols. Herein this dissertation we describe multiple measurement methodologies for both greenhouse gas (GHG) emissions and for ecosystem services. In coastal wetland ecosystems, the need for GHG measurements is paramount to understanding the ability of these ecosystems to reduce …

Integrating Social And Ecological Insights In The Management Plan For An Emerging Conservation Landscape: Kanha-Pench Corridor, Hrishita Negi

All Dissertations

Since its inception in 1973, Project Tiger, which laid the groundwork for India's tiger conservation program, has grown from 9 to 53 intensively monitored and managed tiger reserves. With an increase in tigers' permanent occupancy outside of designated tiger reserves, one of the many challenges confronting India's tiger conservation has been managing its success, with a particular emphasis on this spillover population that ranges extensively in human-dominated, multi-use forest landscapes. This research illustrates the application of a participatory modeling approach to integrate human dimensions with ecological knowledge about tigers in a previously identified forest corridor in Central India. Key dimensions …