Digital Commons Network^™

Molecular Mechanism Governing The Plasticity Of Use-Dependent Spike Broadening In Dorsal Root Ganglion Neurons, Tyler D. Alexander, Stephen Tymanskyj, Kyle J. Kennedy, Leonard K. Kaczmarek, Manuel Covarrubias

SKMC Student Presentations and Publications

Use-dependent spike broadening (UDSB) results from inactivation of the voltage-gated K+ (Kv) channels that regulate the repolarization of the action potential. However, the specific signaling and molecular processes that modulate UDSB have remained elusive. Here, we applied an adeno-associated viral vector approach and dynamic clamping to conclusively demonstrate how multisite phosphorylation of the N-terminal inactivation domain (NTID) of the Kv3.4 channel modulates UDSB in rat dorsal root ganglion (DRG) neurons. The Kv3.4 phosphonull variant promotes slow recovery from inactivation, cumulative inactivation, and UDSB. In contrast, the Kv3.4 phosphomimic variant promotes fast recovery from inactivation and robust resistance to cumulative inactivation …

Developing A Roadmap For Green Port In Timor-Leste, Emanuel Da Silva Maia

World Maritime University Dissertations

No abstract provided.

The Urgency Of Artificial Intelligence Code Of Ethics, Tundjung Herning Sitabuana, Dixon Sanjaya, Ibra Fulenzi Amri, Nethan Nethan

Indonesia Law Review

The era of artificial intelligence has become a characteristic of industrial era 5.0 which has been used in various aspects. Potential economic value of AI has driven various forms of AI innovation development. Exploration of AI tends to override negative impacts of such developments. The emergence of ethical issues with presence of AI encourages the need for a law-based approach to establishing ethical standards to protect entire Indonesian nation. Therefore, this research was conducted to examine urgency for an AI code of ethics. This paper will normatively describe data qualitatively to answer urgency and development of AI code of ethics …

System And Method For The Activation Of Active Ion Transporters Without The Consumption Of Adenosine Triphosphate (Atp) Molecules For The Treatment Of Muscle Fatigue, Wei Chen, Jason Edward Mast, Pengfei Liang

USF Patents

A system and method to control the Na/K pumps for the treatment or prevention of muscle fatigue by applying a synchronization modulation electric field that is effective in synchronizing the Na/K pumps down to individual steps throughout the pumping cycle, thereby synthesizing one ATP for each pumping cycle. The generated ATP molecule compensates the ATP consumed in extrusion of 3 Na ions and pumping 2 K ions such that the net-consumption of ATP for the Na/K pumps controlled by the system and method of the present invention is significantly reduced, theoretically to zero, thereby providing an effective treatment for muscle …

Epigenetic Modification Of Fungi And Uses Thereof, Bill J. Baker, Dennis E. Kyle, Mario Alberto Rodriguez-Pã©Rez, Anne-Claire D. Limon, Ala Azhari

USF Patents

Described herein are methods of epigenetic modification of fungi and uses thereof. Also described herein are compounds that can have antileishmanial activity and formulations thereof. Also described herein are methods of treating leishmanial infection in a subject that include the step of administering a compound or formulation thereof described herein to the subject.

Multi-Sensor Data Fusion And Gis-Drastic Integration For Groundwater Vulnerability Assessment With Rainfall Consideration, Wu Jiazhe, Dai Xinrui, Su Yangcheng, Zheng Xiangtian, Bushra Ghaffar, Rabiya Nasir, Ahsan Jamil, Zeeshan Zafar, Mohammad Suhail Meer, M. Abdullah-Al-Wadud, Rahila Naseer, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

In many areas of the world, particularly in arid and semi-arid regions, groundwater is the primary source of fresh water, and it supplies around one-third of the world's fresh water. Agriculture is the primary economic sector on the coast in the southern district (Nowshera). More food productivity is required due to the expanding population and diminishing agricultural lands, which increases the use of chemical pesticides and fertilizers in farming. The current study was conducted in northwestern parts of Pakistan to evaluate the impacts of the frequent use of pesticides and fertilizers in agricultural fields. Nine hydrogeological parameters were considered, and …

Analisis Prediktif Mutasi Egfr Pada Adenokarsinoma Paru Menggunakan Pendekatan Pembelajaran Mesin, Edwin Nugroho Njoto, Yuri Pamungkas, Atina I.W. Putri, Muhammad. Najib Haykal, Dwinka Syafira Eljatin, Edith Maria Djaputra

Jurnal Penyakit Dalam Indonesia

Introduction. Lung adenocarcinoma is a prevalent form of lung cancer, and mutations in the epidermal growth factor receptor (EGFR) gene are known to play a crucial role in its pathogenesis. This study aimed to develop a machine-learning model to predict EGFR mutations in lung adenocarcinoma patients using clinical and radiological features.

Methods. A case-control study was conducted using a dataset comprising 160 patients with lung adenocarcinoma. Several machine learning algorithms, including decision tree, linear regression, Naive Bayes, support vector machine, K-nearest neighbor, and random forest, were employed to predict EGFR mutations based on variables such as smoking status, …

Determinant Factors Of Unmet Need In Family Plannung (Fp): A Systematic Review, Titin Ifayanti

Preventia: The Indonesian Journal of Public Health

Unmet Needs in family planning (FP) remain a concern in many countries worldwide and can, therefore, adversely affect women, families, and society. Around 12 percent of women worldwide have an unmet need. Such effects include widespread disease, increased maternal mortality, and psychological disorders among women. This study aimed to elucidate the factors associated with the unmet need for family planning. The research approach used was a systematic review, literature was identified through Google Scholar, PubMed, and (NLM): National Library of Medicine. A systematic review and literature analysis of 9 articles was carried out, which utilized secondary data and cross-sectional study …

Relationship Between Personal Hygiene And Environmental Sanitation To The Presence Of Escherichia Coli Bacteria In Food, Erica Ardhana Fathimah Azzahra, Vivi Novianti, Muhammad Al-Irsyad

Preventia: The Indonesian Journal of Public Health

Food safety is one of the significant public health issues, especially in developing countries. The extraordinary incidence of food poisoning and a high number of cases of gastrointestinal infections in Malang City indicate infection with the bacteria that cause dysentery, namely E.coli. This study evaluated hygiene-sanitation practices at food stalls in Area Terusan Ambarawa Malang City. This study aimed to identify Escherichia coli bacteria in 11 food stalls and assess the relationship of environmental sanitation and personal hygiene of food handlers to the presence of E.coli. This study used a quantitative descriptive design with a cross-sectional approach, data collection using …

Participation Of Trans-Women In Females' Sports Competitions: Fairness Vs. Rights To Participating In Sports?, Muhamad Dzadit Taqwa, Valentino Rafael Carofin, Stefanie Gloria, Alvin Tjiang

Indonesia Law Review

A trans-woman is someone who is biologically male at birth and then undergoes gender-affirming surgery, which can include genital feminization surgery, or may not undergo gender-affirming surgery but undergoes other therapies such as cross-sex hormone therapy or other physical organ surgeries apart from genital surgery, in order to be identified as a woman. The participation of trans-women in females' sports has sparked a debate, addressing issues of fairness on one side and transgender rights to participate in sports on the other. The fairness argument is based on the physical advantages that males have when competing against females. Generally, male athletes …

Delays In The International Seabed Authority Mining Code: Insight From Twail And Bbnj Frameworks, Ria Wierma Putri, Yuga Narazua Khanza, Orima Melati Davey, Febryani Sabatira

Indonesia Law Review

The International Seabed Authority (ISA) plays a crucial role in governing the vast expanses of the ocean floor that lie beyond national jurisdictions, referred to as "the Area" under the United Nations Convention on the Law of the Sea (UNCLOS). Although the ISA has established regulations for deep-sea exploration, it has encountered significant challenges in finalizing a comprehensive mining code for resource exploitation. This ongoing delay underscores the notion that legal development is often catalyzed by broader social changes. To comprehend the factors contributing to this delay, it is essential to consider the historical context of UNCLOS 1982, a framework …

Factors Associated With Healthcare Students’ Cognitive Levels Measured By The Classroom Test Of Scientific Reasoning., Alberto J. De Armendi, Amir L. Butt, Kathryn M.L Konrad, Mohanad Shukry, Edmund A. Marek Ii

Graduate Medical Education Research Journal

Introduction: Healthcare student acceptance into graduate and professional school is based on Grade Point Average (GPA), Graduate Record Examination (GRE) scores, interviews, and letters of recommendation, but not on cognition levels. However, educators need to understand students’ cognitive levels to facilitate constructivist learning theory and inquiry-based learning. The aim of this study is to understand the influence of cognition in healthcare students through the administration of the Classroom Test of Scientific Reasoning (CTSR).

Methods: Medical and baccalaureate nursing students were enrolled to answer demographic questions and complete the CTSR. The CTSR rubric score were used to define four operational cognitive …

Development Of Conceptual Scaffolding-Assisted Formative Assessment For Enhancing Understanding Of Temperature And Heat, Ana Lailatul Fitriyah, Sentot Kusairi, Markus Diantoro

Jurnal Pendidikan Sains

This research aims to develop formative assessment media assisted by conceptual scaffolding to improve students’ understanding of temperature and heat, test its validity and practicality, and gauge student responses. Utilizing the ADDIE model, the research follows five stages: Analysis, Design, Development, Implementation, and Evaluation. In the Analysis stage, a literature review was conducted to identify critical components, including formative assessment, conceptual scaffolding, concept mastery, and previous research. The Design stage involved identifying users, defining competencies and indicators, creating a storyboard, integrating assessment components, and determining mastery levels. During the Development stage, the assessment media were developed into a functional product. …

Composite Volume Learning Media Based On Augmented Reality To Enhance Students’ Visual-Spatial Intelligence, Ria Kurniawati, Susiswo Susiswo, Syamsul Hadi

Jurnal Pendidikan Sains

Augmented Reality (AR) technology, a three-dimensional visual tool that integrates virtual objects or environments into real-world displays in real time (Azuma et al., 2001), is particularly useful for grasping complex concepts such as the composite volume of solids, which often confuses students when they need to decompose solids into their individual components. While previous research has predominantly focused on the introduction of solids, spatial nets, and the volume of singular shapes, this study aims to develop composite volume learning media based on AR to enhance students’ visual-spatial intelligence in a valid, practical, and effective manner, aligning with their concrete operational …

Students’ Concept Maps Profile On Environmental Pollution Material During The Covid-19 Pandemic, Sunarni Sunarni, Sri Widoretno, Puguh Karyanto, Bowo Sugiharto, Sri Dwiastuti, Chandra Adi Prabowo

Jurnal Pendidikan Sains

The study investigates the performance of students in constructing Concept Maps (CM) related to environmental pollution material during the COVID-19 pandemic. The data reveals that the overall achievement in CM construction was suboptimal, with no component reaching more than half of its maximum potential. The highest achievement was recorded in the valid relationship component, which attained 9.75% of its maximum possible score. This was followed by the hierarchy component, achieving 7.34%, and the branching component at 3.42%. The pattern component ranked fourth with 1.31%, closely followed by the example component at 1.30%. The lowest performance was observed in the crosslink …

Analysis Of Students’ Problem-Solving Skills In Newton’S Law With 5e Learning Cycle, Nidya Desyana, Sutopo Sutopo, Nandang Mufti

Jurnal Pendidikan Sains

The aim of this study is to identify students’ problem-solving skills in Newton’s laws through the implementation of the 5E learning cycle in the classroom. A pre-experimental design with a one-group pretest-posttest approach was employed. Data on problem-solving skills were collected from students’ pre-test and post-test responses to two essay questions. The indicator with the highest percentage of problem-solving skills was useful description (83% of students), while the indicator with the lowest percentage was specific application of physics (33% of students). Due to the non-normal distribution of the data, the Wilcoxon test was utilized. The results indicated a significant difference …

Design Of Motivational-Realistic-Pancasila Learning In Mathematics, Marup Marup, Suradi Tahmir, Ahmad Talib, Nurzatulshima Kamaruddin

Jurnal Pendidikan Sains

Learning mathematics in class greatly influences students' learning success both in terms of knowledge and attitudes. In carrying out learning, a learning design is needed that can foster student motivation so that they provide learning outcomes to the learning objectives. Motivational-Realistic-Pancasila learning design is considered to be an alternative solution. Morela is a design that combines motivational, realistic indicators and Pancasila values. The teaching of mathematics in the classroom significantly influences students' academic success, both in terms of knowledge and attitude. To effectively carry out the teaching process, a well-designed instructional approach is necessary to foster students' motivation to achieve …

Dental Remains Of Pachyportax (Bovidae) From Late Miocene Deposits Of Jhelum, Punjab, Pakistan, Saira Ashfaq, Muhammad Rizwan, Maryam Mushtaq, Umar Naveed Saqib, Sheraz Khan, Hifza Zahid, Muhammad Arshaid, Tabassum Nawaz

Journal of Bioresource Management

The upper Dhok Pathan Formation is characterized to newly found Pachyportax fossils from Late Miocene outcrops in the Hasnot region. The discovered dental remains of Pachyportax include upper and lower molars. Based on morphometry, the examined tooth material was identified, and the specimens were categorized as Pachyportax latidens and Pachyportax nagri. A well-known example is Pachyportax latidens, but Pachyportax nagrii stands out due to its rare fossil record from the middle Siwaliks. Potwar Pleateu is the most productive region for the deposition of vertebrate fossils (Pilbeam et al., 1979; Badgley et al., 2008). Bovids in open environments are …

Green Design Of Plant Based Pharmaceutical Drugs: Example Of A Wound Healing Topical Cream With Plectranthus Bojeri (Benth) Hedge Lamiaceae Extract, Helga Rim Farasoa, Marie Louise Razafindravao, Rojo Fanambinantsoa Andriamiarantsoa, Gerard Cecilien Raboanary, Jean Marie Razafindrakoto, Voahangy Ramanandraibe Vestalys

Journal of Bioresource Management

To ensure the perennity of natural resources, the valorisation process of herbal pharmaceuticals must be assessed for sustainability from the very beginning of its design. No specific tools have been developed for this particular field so far. We demonstrate in this study that existing green design tools can be adapted to evaluate plant-based products manufacturing process. As the example of a topical cream using Plectranthus bojeri (Benth) Hedge LAMIACEAE extract was considered, we first confirmed the traditional use of this plant for wound healing. It acts by accelerating the re-epithelialisation phase. Using the Vermeer Cosmolife version 0.24 software tool the …

Study Of The Incorporation Of Date Stone Powder On Technological And Rheological Characteristics Of Common Wheat Flour, Djilali Bouhadi, Hamza Belkhodja, Zouaoui Benattouche, Abderrahmane Remil, Ahmed Hariri

Journal of Bioresource Management

The fortification of bakery products with bioactive and functional substances is the main focus of food sciences. These nutrients include date fruits (Phoenix dactylifera L.) and their byproducts. This work aims to illustrate the effects of using date components in bakery products and to determine how these effects affect the products' technological, rheological, and sensory qualities. To achieve this purpose, date powder was introduced in bread making procedure with different rates (1, 3, 5, 7 and 9 %). Then, the physicochemical, sensorial and rheological characteristics was determined. In terms of bread qualities, date powder improved the volume and form …

Educational Strategy For Service Learning Using Stem Activities: A Case Study Of A Malaysian Secondary School, Nurulsaidah Abdul Rahim, Suzaliza Mustafar

ASEAN Journal of Community Engagement

This paper discusses the Service Learning Malaysia-University for Society (SULAM) program in developing an educational strategy for science, technology, engineering, and mathematics (STEM) learning at a Malaysian secondary school. The implementation of the 60:40 policy (60% STEM and 40% non-STEM) in Malaysia is to increase the number of students studying STEM. However, as of 2022, this policy had failed to achieve this target ratio. Additionally, Malaysian students’ scores on the Program for International Student Assessment (PISA) in the categories of math, science, and language literacy decreased from 2018 to 2022. This paper argues that SULAM represents a promising approach to …

A Mother's Understanding Of Her Adolescent: A Social Anxiety Study, Cheronda Pinkard

Walden Dissertations and Doctoral Studies

Social anxiety disorder (SAD) affects 1% to 13% of adolescents, often placing significant demands on their caregivers. Mothers frequently adapt their behaviors to accommodate their child’s anxiety, which may impact their well-being and the parent-child relationship. This qualitative study explored the lived experiences of mothers accommodating adolescents with SAD to understand better the emotional and relational toll of this caregiving role. The problem addressed is the limited understanding of how maternal accommodation affects mothers. Mental health practitioners, educators, and policymakers may benefit from this research by gaining insight into these families' challenges and informing family-centered interventions and support services. Guided …

Expenditure Control By Optimization Of Leftover Food In The Holiday Inn Hotel Kemayoran, Achmad Raihan Suryadi Ningrat

Journal of Indonesian Tourism and Policy Studies

The growth of tourism in Indonesia has positively impacted the hospitality sector, particularly in the kitchen department which is in charge of providing food and beverages to guests. Kitchen Hotel Holiday Inn Kemayoran wants to optimize the use of food scraps to control expenses without compromising food quality and hygiene. The results showed that there was a waste of food ingredients at the butcher and commissary in the hotel's main kitchen, such as chicken bones, shrimp shells, and vegetable ingredients. However, the leftovers can be processed with creative use into new dishes that reduce waste. This study provides theoretical benefits …

Institutional Support's Influence On Green Beekeeping Adoption In Resource-Constrained Biharamulo Forest Reserve, Tanzania: The Extended Theory Of Planned Behavior, Haruna Athumani, Ranger Kanan, Gerald Zachary Paga Tinali

Business Management Review

Green production practices are crucial for environmental conservation, yet scholarly research on green beekeeping remains limited. This study seeks to enhance the Theory of Planned Behavior (TPB) by developing an extended model of Institutional Support theory of Planned Behavior (ISTPB) to understand better beekeepers' behavior toward adopting green beekeeping practices. The model focuses on institutional support and its role in shaping individual behavior related to green beekeeping adoption. Using structural equation modeling (SEM), the study's empirical results show that institutional support and the three original TPB components, i.e., attitude, subjective norms, and perceived behavioral control, positively and significantly influence green …

Mathematical Modelling And Analysis For The Co-Infection Of Viral And Bacterial Diseases: A Systematic Review Protocol, Timothy Kiprono Yano, Ebenezer Afrifa-Yamoah, Julia Collins, Ute Mueller, Steven Richardson

Research outputs 2022 to 2026

Introduction Breaking the chain of transmission of an infectious disease pathogen is a major public health priority. The challenges of understanding, describing and predicting the transmission dynamics of infections have led to a wide range of mathematical, statistical and biological research problems. Advances in diagnostic laboratory procedures with the ability to test multiple pathogens simultaneously mean that co-infections are increasingly being detected, yet little is known about the impact of co-infections in shaping the course of an infection, infectivity, and pathogen replication rate. This is particularly true of the apparent synergistic effects of viral and bacterial co-infections, which present the …

Nurses’ Empathy, Burnout, And Contentment With Life In Turkey, Sevinç Mersin, Özlem İbrahimoğlu, Merve Tuncer, Ali Arslanoğlu

Makara Journal of Health Research

Background: Empathy has various consequences for nurses. Therefore, its effects on nurses should be identified. Thus, this study aimed to determine the relationships between empathy, burnout, and level of contentment with life in nurses and the characteristics that affect them.

Methods: This descriptive–correlational study was conducted on 653 nurses in Turkey between November and December 2021. Data were collected using an information form, the Basic Empathy Scale, Burnout Measure Short Scale, and Contentment with Life Assessment Scale.

Results: A positive, weak, and significant relationship was noted between the mean Basic Empathy Scale and Burnout Measure Scale scores. …

Predicting Tuberculosis Vulnerability Based On Environmental Factors Using Multi-Criteria Analysis In Bukittinggi, Eka Budi Satria, Indang Dewata, Iswandi Umar, Nurhasan Syah, Linda Handayuni, Evi Hasnita

Media Kesehatan Masyarakat Indonesia

Tuberculosis is still an infectious disease problem and the main cause of death in Indonesia, where there was an increase in cases from 301 per 100,000 population (2020) to 354,000 per 100,000 population (2021), with the death rate increasing by 55%. This research aims to determine the TB vulnerability cluster influenced by the main risk factors, namely TB prevalence, cure rate, immunization, population density, and population arrivals in Bukittinggi, using the Weight Product (WP) analysis method, and then describe them by mapping tuberculosis vulnerability. The findings indicate that four sub-districts exhibit the highest levels of tuberculosis vulnerability: Tarok Dipo (0.0379), …

Determinants Of Wasting Among Children Aged 6–23 Months In Indonesia, R. Trikoriyanto E. Koritelu, Ahmad Syauqy, Ani Margawati

Media Kesehatan Masyarakat Indonesia

Wasting is a form of malnutrition that is a significant concern globally, including in Indonesia. It has a detrimental impact on children's health, the quality of human resources, and a country's overall development. This study aims to examine the prevalence and risk factors associated with wasting in children aged 6–23 months in Indonesia. The study design is cross-sectional, utilizing secondary data from the 2022 Indonesian Nutrition Status Survey. Data collection was conducted throughout Indonesia between March and December 2022. The sample size for this study was 70,414 children aged between 6 and 23 months. Bivariate analysis (χ² test) was …

Head-To-Head Comparison Of Aptamer- And Antibody-Based Proteomic Platforms In Human Cerebrospinal Fluid Samples From A Real-World Memory Clinic Cohort, Raquel Puerta, Amanda Cano, Pablo García-González, Fernando García-Gutiérrez, Maria Capdevila, Itziar De Rojas, Clàudia Olivé, Josep Blázquez-Folch, Oscar Sotolongo-Grau, Andrea Miguel, Laura Montrreal, Pamela Martino-Adami, Asif Khan, Adelina Orellana, Yun Ju Sung, Ruth Frikke-Schmidt, Natalie Marchant, Jean Charles Lambert, Maitée Rosende-Roca, Montserrat Alegret, Maria Victoria Fernández, Marta Marquié, Sergi Valero, Lluís Tárraga, Carlos Cruchaga, Alfredo Ramírez, Mercè Boada, Bart Smets, Alfredo Cabrera-Socorro, Agustín Ruiz

Faculty, Staff and Student Publications

High-throughput proteomic platforms are crucial to identify novel Alzheimer’s disease (AD) biomarkers and pathways. In this study, we evaluated the reproducibility and reliability of aptamer-based (SomaScan® 7k) and antibody-based (Olink® Explore 3k) proteomic platforms in cerebrospinal fluid (CSF) samples from the Ace Alzheimer Center Barcelona real-world cohort. Intra- and inter-platform reproducibility were evaluated through correlations between two independent SomaScan® assays analyzing the same samples, and between SomaScan® and Olink® results. Association analyses were performed between proteomic measures, CSF biological traits, sample demographics, and AD endophenotypes. Our 12-category metric of reproducibility combining correlation analyses identified 2428 highly reproducible SomaScan CSF measures, …

Gender Rebellion: Gender Non-Conformity As An Act Of Resistance In The Hunger Games, Julia Koncurat

Criterion: A Journal of Literary Criticism

No abstract provided.