Epithelial Responses And Remodeling In The Submandibular Gland Post-Irradiation, Victoria Gellatly

Electronic Theses & Dissertations (2024 - present)

Radiation therapy for head and neck cancer often causes irreversible salivary gland dysfunction, resulting in chronic xerostomia. Understanding the cellular and molecular mechanisms underlying this dysfunction is essential for developing regenerative therapies. Given the cellular complexity of the salivary gland single-cell RNA sequencing (scRNA-seq) provides a powerful approach to investigate cell-type-specific injury responses to ionizing radiation (IR) and uncover transcriptional changes that may be masked in bulk analyses. This study investigates the cellular and molecular responses of the murine submandibular gland (SMG) to irradiation, with a focus on epithelial loss and remodeling, and regenerative failure. In order to effectively use …

Association Of Non-Communicable Diseases With Severe Covid-19 Among People Living With And Without Diagnosed Hiv/Aids In New York State, Ravi Kumar Balu

Electronic Theses & Dissertations (2024 - present)

Background: People living with diagnosed HIV (PLWDH) have a higher chance of co-infections and co-morbidities than the general population. When SARS-CoV-2 was first reported in China in December 2019 and later declared a pandemic, it was speculated that PLWDH might be more prone to SARS-CoV-2 infection and severe disease outcomes given their increased vulnerability to other respiratory infections like influenza, pneumococcal pneumonia and tuberculosis. However, several facets of COVID-19 disease in PLWDH are incompletely understood, including whether non-communicable diseases (NCDs) are strong risk factors for severe disease outcomes and death as they are in the general population.

Methods: The data …

The Intermediate And Remote Effects Of Acute Juvenile Stress Upon Auditory Fear Learning, Recognition Memory, And Anxiety Measures In A Rodent Model Of Ptsd, Laura J. Baron

Electronic Theses & Dissertations (2024 - present)

Abstract

Early-life stress is a risk factor for increased susceptibility to stress- and trauma-related disorders, including Posttraumatic Stress Disorder (PTSD). PTSD is characterized by exposure to trauma that results in exaggerated and extinction-resistant fear responses that persist for over a month. Understanding how the severity of early-life stressors in animal models impacts adult behavior, cognition, and underlying neurobiology could aid in the development of more effective PTSD treatments.

Various early-life stress models, especially in infant rats, have been used to induce stress and assess PTSD like-symptoms. Different stressors impact short- and long-term behavior, with some effects influenced by developmental timing …

Contributions Of Birthing People’S Prenatal Parasympathetic Nervous System Functioning And Postnatal Sensitivity On Infant Temperament, Amanda M. Flagg

Electronic Theses & Dissertations (2024 - present)

Grounded in developmental psychobiology, this research aimed to elucidate how birthing people’s physiological regulation during pregnancy may shape the early emergence of socioemotional development in early infancy. The present study examined how birthing people’s prenatal parasympathetic nervous system (PNS) activity, specifically baseline high-frequency heart rate variability (HF-HRV) and HF-HRV withdrawal, and postnatal sensitivity contributes to infant temperamental reactivity at six months of age. The study aimed to clarify early developmental mechanisms through which birthing people’s PNS shapes emerging infant temperament. Data were drawn from a longitudinal cohort of Black and African American birthing people, a population underrepresented in psychophysiological research, …

Investigating Rna Dysfunction Of Inherited Neuromuscular And Neurodevelopmental Disease, Jacob H. Schroader

Electronic Theses & Dissertations (2024 - present)

ITPase deficiency is a rare but fatal, autosomal recessive enzyme deficiency involving encephalopathy, microcephaly, congenital cataracts, hypotonia, developmental delay, and dilated cardiomyopathy. Within a decade since the original description of the severe form in humans, there are huge gaps in the field regarding the underlying molecular mechanisms driving pathogenesis resulting from ITPase deficiency. Past studies have focused on characterization of the organism level ITPase-deficient phenotype, but the molecular and cellular characterization remains to be fully described. Due to the biochemical function and established biological role of the ITPase enzyme, investigation into the consequences of inosine accumulation and misincorporation into RNA …

Clinical Experiences In Conducting Empirically Supported Treatments For Insomnia, Sondra S. Tiab

Electronic Theses & Dissertations (2024 - present)

Controlled research shows that cognitive-behavioral therapy (CBT) is an effective treatment for insomnia, yet clinician experiences with applying CBT in routine settings has received limited attention. This study replicated and extended upon the Two-Way Bridge initiative (Goldfried et al., 2014), which aimed to establish a dialogue between researchers and clinicians on the identification of variables that promote and interfere with the effectiveness of evidence-based therapies. This survey study asked clinicians to identify variables they have encountered that make it challenging to implement CBT and related interventions for insomnia. N = 182 clinicians completed an online survey on typical assessment practices, …

Postnatal Programming Of Infant Temperament At 12-Months: A Test Of Lactation Programming Theory, Lydia Bierce

Electronic Theses & Dissertations (2024 - present)

The current study examined how maternal cortisol and breastfeeding duration across the first six months postpartum might relate to infant temperament profile membership at 12 months in 322 low-income Mexican American mother-infant dyads (46.3% male). Results revealed that maternal postnatal cortisol levels were significantly moderated by breastfeeding duration to predict infant temperament profile (β = 0.14, p = .030) such that more maternal cortisol was linked to higher likelihood of belonging to a high positive affect, well-regulated profile when mothers breastfed for above average durations. This suggests that while maternal cortisol in breastmilk might initially shape infant negative temperament, …

Essays On Health Economics, Yiran Han

Electronic Theses & Dissertations (2024 - present)

The first chapter examines relationships between physicians exposed to new drugs’ clinical trials and prescribing. Clinical trials benefit patients directly by providing novel treatments, but little is known about the indirect effects of clinical trials on physician prescribing through localized knowledge spillover. This study examines whether exposure to a clinical trial of a new drug in a physician’s local geographic area affects the physician’s propensity to prescribe the drug, i.e. a localized knowledge spillover from clinical trial sites to physician. Utilizing the Medicare Part D prescribing patterns of more than 10,000 physicians across 29 new cancer drugs approved by the …

Photoswitchable Inhibitors Of Eaat3, Karly Suhr

Electronic Theses & Dissertations (2024 - present)

Azobenzene is a photoswitchable molecule known for its high conversion yield and repeatability. The inclusion of an azobenzene moiety with a known inhibitor of your target of interest allows for greater study of function as well as potential therapies. Three derivatives were designed from azobenzene and known inhibitor of EAATs, TBOA, to synthesize photoswitchable inhibitors of EAATs. Further investigation into the function of EAATs and development of a specific inhibitor for EAAT3, an important glutamate transporter in the brain required for proper function, can then be conducted. Photoisomerization studies on the derivatives were conducted using UV/vis spectroscopy and NMR spectroscopy. …

Stress And Resilience In Higher Education Administrators: Exploring The Role Of Mindfulness, Michael Baumgardner

Electronic Theses & Dissertations (2024 - present)

This dissertation explores stressors experienced by higher education administrators (HEAs) and examines the role of mindfulness practices in mitigating stress and fostering resilience and job satisfaction. HEAs manage essential institutional functions yet face intensifying pressures from volatile funding streams, shifting demographics, changing public perceptions, political and cultural challenges, technological disruptions, and pandemic-related change. Despite HEAs central role in sustaining higher education, limited research examines how these professionals experience stress, and even less has considered mindfulness as a potential resource for coping and resilience.

Guided by a qualitative methodological approach, this study draws on semi-structured, thick description interviews with 18 HEAs …

Y’All Means All: Pro-Choice Abortion Activism In West Texas Post-Dobbs, Hannah S. Noblewolf

Electronic Theses & Dissertations (2024 - present)

In the spring of 2021, a six-week abortion ban passed by popular vote in the city of Westerburg, Texas. It had a civil enforcement mechanism, allowing someone to collect a reward of $2,000 if they successfully sued someone they reported for “aiding and abetting” abortion. The ban, called the Westerburg Sanctuary City ordinance, was referred to as “bounty hunting.” When the ban passed it became the template for the state-level Texas Heartbeat Act, which provides a greater financial reward for a successful civil suit, with a minimum of $10,000 plus legal fees. In the face of this ban, pro-choice activists …

Identification Of Fentanyl And Fentanyl Analogs Found In Human Urine Using Gas Chromatography-Mass Spectrometry, Adam M. Fisher

Electronic Theses & Dissertations (2024 - present)

Identification of fentanyl and its analogs in unknown samples is a frequent practice completed in forensic crime labs, as the fentanyl epidemic continues. With the continued increase in illicit drug use, crime labs are not able to keep up with the flooding of new fentanyl analogs being developed, resulting in new analogs slipping past the crime labs’ authority. This research is to start to develop a database of commonly found fentanyl analogs in New York State. Gas Chromatography-Mass Spectrometry (GC-MS) is a widely used method for the detection and identification of illicit drugs in forensic crime labs. A database that …

Ai-Driven Differentiation And Quantification Of Metal Ions Using Ities Electrochemical Sensors, Muzammil M. N. Ahmed, Parth Ganeriwala, Anthi Savvidou, Nicholas Breen, Siddhartha Bhattacharyya, Pavithra Pathirathna

Electrical Engineering and Computer Science Faculty Publications

Electrochemical sensors, particularly those based on ion transfer at the interface between two immiscible electrolyte solutions (ITIES), offer significant advantages such as high selectivity, ease of fabrication, and cost effectiveness for toxic metal ion detection. However, distinguishing between cyclic voltammograms (CVs) of analytes with closely spaced half-wave potentials, such as Cd2+ and Cu2+, remains a challenge, especially for non-expert users. In this work, we present a novel methodology that integrates advanced artificial intelligence (AI) models with ITIES-based sensing to automate and enhance metal ion detection. Our approach first employed a convolutional neural network to classify CVs as either ideal or …

Characterization Of The Erv41-Erv46 Complex As A Retrograde Receptor For Misfolded Secretory Proteins, John Andrew Fuesler

Dartmouth College Ph.D Dissertations

The Endoplasmic Reticulum (ER), the site of secretory protein biosynthesis

provides a favorable environment to promote polypeptide folding, protein

oligomerization and export. Although the ER contains many chaperones and other

factors that assist in protein folding, this process is error prone. Eukaryotes have

evolved protein quality control checkpoints to maintain homeostasis in the secretory

pathway, however these processes are imperfect and may result in proteotoxicity

when toxic levels or aggregates of proteins arise. Mutations in proteins involved in

trafficking in the early secretory pathway are closely associated with disease states.

Therefore, it is of great interest to further understand how …

Biochemical And Molecular Analysis Of Anr-Dependent Microoxic Fitness Factors In Pseudomonas Aeruginosa, Stacie E. Balsam

Dartmouth College Ph.D Dissertations

Pseudomonas aeruginosa is a prominent opportunistic pathogen that is often found in microoxic environments like sites of infection and colony biofilms. P. aeruginosa can grow at oxygen (O2) at concentrations as little as 3 μM and also grows anaerobically by generating energy using nitrate as an alternate electron acceptor. An important way P. aeruginosa adapts to low O2 is through Anr, a transcription factor that upregulates many genes important for microoxic and anoxic fitness.

Specifically, Anr regulates mhr which encodes a hemerythrin protein (Mhr) that binds O2 with affinities relevant to microoxia and is also necessary for full fitness of …

Data‐Driven Approach To Dynamic Resting State Functional Connectivity In Post‐Traumatic Stress Disorder: An Enigma‐Pgc Ptsd Study, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Using functional magnetic resonance imaging (fMRI), symptoms of posttraumatic stress disorder (PTSD) have been associated with aberrations in brain networks in the absence of a given cognitive demand or task, called resting-state networks. Prior work has focused on disruption in the static functional connectivity (FC) among specific regions constrained by a priori hypotheses. However, dynamic FC, an approach that examines brain network characteristics over time, may provide a more sensitive measure to understand the network properties underlying dysfunction in PTSD. Further, using a data-driven analytic approach may reveal the contribution of other larger network disturbances beyond those revealed by hypothesis-driven …

What Can Conjuring Tell Us About Cognition? The Future Of The Science Of Magic, Geoff G. Cole, Gustav Kuhn

School of Psychology

During the past 20 years a number of articles have appeared within a field that has become known as the “science of magic.” This subdiscipline of psychology posits that the ancient art of conjuring can be used to develop psychological theories and knowledge, and more than 150 peer-reviewed articles have now been published. In the current article, we critically evaluate what can be considered as the three central tenets of the discipline: that the methods used in magic can be incorporated within experimental research, that magicians have particular insight into human cognition and behavior, and that the deconstruction of magic …

Comparing The Sensitivity And Specificity Of Novel Motor Assessments For Traumatic Brain Injury, Paula K. Johnson, Ariana M. Hedges-Muncy, Erin D. Bigler, Lorie Richards, Steven Knight Charles

Faculty Publications

Background: Portable technology that records movements with high accuracy provides potential for sensitive clinical movement tests for individuals who experienced a traumatic brain injury (TBI). Objective: (1)To present impairments assessed using markerless motion capture (MMC) and (2) to compare the sensitivity and specificity of the MMCmediated tests to each other and to common clinical tests. Design: Screening study, using as criterion standard the ability to classify participant with TBI versus control participant. Setting: Research laboratory. Participants: The study included 30 individuals with TBI and 101 control participants. Entry criteria included most recent head injury < 5 years old, no history of movement issues prior to injury, no movement-affecting medications, and sufficient cognitive ability to follow instructions. Interventions: Not applicable. Main Outcome Measures: Performance on MMC-mediated tests and existing clinical analogs. MMC-mediated tests included finger oscillation, simple reaction time, and visually guided movement tasks. For comparison, participants also completed the following clinical tests: Halstead–Reitan finger tapping, simple reaction time test, and Beery Visuomotor Integration test. Impairments were identified as test scores of participants with TBI that fell outside of the 95% interval of control participants’ test scores. Random forest analysis was used to calculate the sensitivity and specificity of MMC and clinical tests according to their ability to correctly classify participants with TBI and control participants. Results: MMC-mediated tests revealed impairments in more participants with TBI than clinical tests in all three TBI groups (mild, repeated, and moderate to severe). Similarly, MMC-mediated tests revealed a higher percentage of scores as impairments than clinical tests in all three groups with TBI. Furthermore, MMC-mediated tests proved more sensitive and more specific than clinical tests (70% versus 50% and 98% versus 93%, respectively). Conclusion: MMC-mediated tests are sensitive and specific (compared to traditional clinical tests) and have potential to fill a gap in clinical care of TBI.

Rise Above: Supporting Teacher Candidates With Autism Through Specialized Coaching, Allison N. Oliver

Journal of Case Learning & Exceptional Learners

This case study examines the impact of specialized coaching support for preservice special education teachers with autism during their senior year of their teacher preparation program with specific focus on practicum and student teaching placements. The study involved two undergraduate students, ages 21 and 20, diagnosed with autism spectrum disorder, who were in their final year of a special education licensure program at a university in a rural area in the Midsouth region of the United States. Both participants had disclosed their disability status and requested accommodations through university services. The coaching process evolved through four distinct phases over two …

Characterization Of Bacterial And Fungal Populations In Retail Kefirs In Ireland, Léon Maughan, Leonard Koolman, Guerrino Macori, Christina Killian, Séamus Fanning, Paul Whyte, Declan Bolton

Research Outputs: 2025-Present

No abstract provided.

Apoptotic Cell Death Induced By Copper (Ii), Manganese (Ii) And Silver (I) Complexes Containing Bridging Dicarboxylate And 1,10-Phenanthroline Ligands: One Of The Multi-Modes Of Anticancer Activity?, Ella O’Sullivan, Denis O’Shea, Michael Devereux, Orla Howe

Research Outputs: 2025-Present

Cu(II), Mn(II) and Ag(I) complexes incorporating bridging dicarboxylate and 1,10-phenanthroline ligands have exhibited anti-cancer potential with significant in vitro and in vivo cytotoxic efficacies. Our study focuses on regulated cell death process of apoptosis as a mode of action of the anti-cancer activity by the complexes. Cytotoxicity screening of the complexes demonstrated all the metal-dicarboxylate-phenanthroline complexes exhibit superior activity compared to their non-phenanthroline containing precursors, in addition to cisplatin. The Cu(II) and Mn(II) complexes were shown to induce reactive oxygen species (ROS) but this was not observed for the Ag(I) analogues. Furthermore, apoptosis was found to be induced by all …

Integration Of The Portionsize Ed App Into Snap-Ed For Improving Diet Quality Among Adolescents In Hawaii: A Randomized Pilot Study, Emerald S. Proctor, Kiari H.L. Aveiro, Ian Pagano, Lynne R. Wilkens, Leihua Park, Leilani Spencer, Jeannie Butel, Corby K. Martin, John W. Apolzan, Rachel Novotny, John Kearney, Chloe P. Lozano

Research Outputs: 2025-Present

Background/Objectives: Coupling mobile health (mHealth) technology with community-based nutrition programs may enhance diet quality in adolescents. This pilot study evaluated the feasibility, acceptability, and preliminary efficacy of integrating PortionSize Ed (PSEd), an image-assisted dietary assessment and education app, into the six-week Hawaii Food and Lifeskills for Youth (HI-FLY) curriculum delivered via Supplemental Nutrition Assistance Program Education (SNAP-Ed). Methods: Adolescents (grades 6–8) from two classrooms were cluster-randomized into HI-FLY or HI-FLY + PSEd. Both groups received HI-FLY and completed Youth Questionnaires (YQ) and food records (written or app-based) at Weeks 0 and 7. Feasibility and acceptability were assessed via enrollment, attrition, …

Notice Pleading’S Quiet Return, Alexander A. Reinert

Articles

Fifteen years ago, the Supreme Court announced two significant civil procedure decisions – Bell Atlantic Corp. v. Twombly, 550 U.S. 544 (2007), and Ashcroft v. Iqbal, 556 U.S. 662 (2009). Together, Iqbal and Twombly marked a new approach to pleading in federal courts. No longer would courts apply the forgiving notice pleading standard, in force since the 1938 adoption of the Federal Rules of Civil Procedure. In its place, the Court introduced plausibility pleading, inviting district courts to apply their “judicial experience and common sense” to decide whether a claim was “plausible.” Commentators expressed alarm, predicting that the new standard …

Interactions Between Lipopolysaccharide And Capsule Retention In Klebsiella Pneumoniae And The Resultant Effects On Macrophages, Juliane Leigh Nguy

UNF Graduate Theses and Dissertations

Klebsiella pneumoniae is the third most common cause of nosocomial infections in the United States. The capsular polysaccharides (CPS) are virulence factors allowing K. pneumoniae to evade host immune systems. The current model of capsule structure indicates that CPS fibrils interact with the external O-antigen of lipopolysaccharide molecules to enhance retention to the bacterial outer membrane. These interactions may influence pathogenicity in clinically relevant strains. This study characterized alterations to LPS and CPS structure, the impact of these changes on capsule retention, membrane permeability, biofilm formation, and macrophage interactions. LPS and CPS were quantified and visualized in four strains of …

Spatial And Temporal Patterns In Short-Term Surface Sediment Deposition And Accretion At The Guana Tolomato Matanzas National Estuarine Research Reserve: Implications For Resilience Of Coastal Wetlands To Sea-Level Rise, Jacob Michael Berna

UNF Graduate Theses and Dissertations

Coastal wetlands are at risk of drowning due to the increasing threat of rising sea levels. Wetlands will have to build in elevation vertically or migrate horizontally to survive. Previous research has demonstrated that some wetlands have the potential to naturally build in elevation over time if deposition and accretion rates from allochthonous sediment delivery are substantial, but work in this area has been limited, and many coastal wetlands remain understudied. Portions of Northeast Florida are especially lacking in short-term surface deposition and accretion data. Without surface rates it is difficult to determine the vulnerability of different wetlands to rising …

A Pilot Study Of The Freeze Response: Physiological Markers Under Threat Versus Safety Video Conditions, Ula Mccarthy

UNF Graduate Theses and Dissertations

This pilot study examined physiological markers of the human freeze response during exposure to threat and safety-based video stimuli. The freeze response is an adaptive defense mechanism characterized by reduced heart rate and heightened sympathetic arousal (Roelofs, 2017; Hagenaars et al., 2014; Sagliano et al., 2014; Hermans et al., 2013). 20 university students were randomly assigned to view either a threatening or safety-based video clip while heart rate and electrodermal activity (EDA) were recorded using Biopac Bionomadix wireless systems. Trauma severity and PTSD symptomatology were assessed through validated self-report measures (BTQ; Schnurr et al., 1999), (PCL-5; Weathers et al., 2013). …

Leucine Catabolism Is Associated With Longevity In Female Eastern Lubber Grasshoppers, Kerri R. Conklin

UNF Graduate Theses and Dissertations

Background & Aims: Dietary isoleucine restriction can improve metabolic health and increase lifespan. It has been hypothesized that shifts in branched-chain amino acid catabolism drives this longevity effect. Impaired branched-chain amino acid catabolism is linked to several age-related diseases. We investigated whether dietary isoleucine restriction increases leucine catabolism and associates with longevity and full reproduction.

Methods: In two experiments, adult female Eastern Lubber grasshoppers (Romalea microptera) were assigned to either a high-quality diet (Balanced ile), or diets with varying isoleucine content (Moderate ile-R and Severe ile-R). In Experiment 1, we used a low-energy (Low Lettuce) group as a positive …

Leaving It All Behind: A Storied Experience, Brandi Sheree Wynne Winfrey

UNF Graduate Theses and Dissertations

Diversity, equity, and inclusion (DEI) professionals are experiencing an unprecedented time as conservative politicians and legislators work to dismantle DEI in higher education. In 2022, Florida became one of the first states to introduce and enact anti-DEI legislation. Few studies have examined or investigated the lived experiences of DEI professionals currently living in the midst of this experience. The purpose of this narrative inquiry was to capture and restory the lived experiences of DEI professionals employed at public Florida universities during the introduction and enactment of anti-DEI legislation. Five co-composers contributed their stories of experience as data to this narrative …

What’S For Dinner? A Multi-Pronged Approach Investigating The Foraging Habits And Diet Of St. Johns River Bottlenose Dolphins (Tursiops Erebennus), Andrea Leigh Swinehart

UNF Graduate Theses and Dissertations

Wildlife population management depends on knowledge of the population’s foraging ecology. A community of resident Tamanend’s bottlenose dolphins (Tursiops erebennus) utilizes the St. Johns River (SJR) in Jacksonville, Florida, and members of the community are regularly sighted emaciated or with skin lesions. Anthropogenic disturbances may contribute to further health decline, therefore Chapter One analyzed SJR foraging dolphin group habitat use before, during, and after a large-scale dredging event known as the Jacksonville Harbor Deepening Project (JHDP). Kernel density estimates (KDEs) of foraging dolphin group sightings were generated to estimate 95% utilization distributions (i.e., foraging home ranges) for three …

Assessment Of Surface Area Application Ratios For Beach Sand Treated Via Surface Percolated Micp-Bioslurry For Erosion Mitigation, Connor J. Marlin

UNF Graduate Theses and Dissertations

Rapid shoreline erosion associated with sea-level rise is an ongoing threat to coastal infrastructure. Traditional stabilization techniques, such as revetments, seawalls, and periodic nourishment, often prove costly, ecologically disruptive, or provide only temporary protection. Microbially Induced Calcite Precipitation (MICP) and its operational variant, bioslurry, present a biologically inspired alternative capable of forming a cemented surface crust that reduces soil erodibility. Previous laboratory studies typically prescribed a solution dosage as a percentage of pore volume (%PV). While geotechnically sound, this metric is poorly suited to field deployment across a large area. This thesis evaluates surface-area-based dosing (L/m²) as the primary dosage …