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Can Organs Be Generated From A Patient’S Own Stem Cells?, David Heimowitz Jan 2025

Can Organs Be Generated From A Patient’S Own Stem Cells?, David Heimowitz

The Science Journal of the Lander College of Arts and Sciences

The global shortage of transplantable organs represents a critical medical challenge, with current organ donation systems meeting less than 10% of the worldwide need. This situation has spurred intensive research into regenerative medicine, particularly focusing on the potential of generating organs from a patient’s own stem cells. This review examines the current state of stem cell research and its applications in organ generation, analyzing both the progress made and the challenges that remain. Through a comprehensive analysis of recent literature and clinical trials, the study explores the fundamental principles of stem cell biology, current therapeutic applications, and the role of …

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Limb Regeneration In Amphibians & Mammals, Jacob Mamrout Jan 2025

Limb Regeneration In Amphibians & Mammals, Jacob Mamrout

The Science Journal of the Lander College of Arts and Sciences

This thesis will give an in-depth analysis into the mechanisms of regeneration that amphibians use and how the blastema forms. It will also discuss genes and proteins that play a role including the P53 gene, Transforming Growth Factor Beta, CD59, and others. Regenerative potential of mammals will be discussed using the information found. Findings include that mammals may have regeneration potential because of the ability we have to deactivate certain genes to allow cells to dedifferentiate.

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The Bidirectional Gut-Brain Axis: Impact Of Dysbiosis On Depression Through The Hpa Axis, Matan Shiller Jan 2025

The Bidirectional Gut-Brain Axis: Impact Of Dysbiosis On Depression Through The Hpa Axis, Matan Shiller

The Science Journal of the Lander College of Arts and Sciences

Emerging research suggests that depression is not solely a brain disorder but is deeply influenced by the gut microbiome. The gut-brain axis (GBA) is a bidirectional communication system linking the gastrointestinal system and the brain, modulating mood, behavior, and mental health. Gut microbiota produce metabolites, such as short-chain fatty acids (SCFAs) and tryptophan catabolites, that influence neurotransmission and the stress response via the hypothalamic-pituitary-adrenal (HPA) axis. Dysbiosis, or microbial imbalance, disrupts these pathways, contributing to a major depressive disorder (MDD). Evidence from germ-free animal studies and fecal microbiota transplants (FMT) highlights the role of gut microbiota in emotional regulation and …

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Gut Microbiome Dysbiosis And Its Contribution To Carcinogenesis, Daphne Grabie Jan 2025

Gut Microbiome Dysbiosis And Its Contribution To Carcinogenesis, Daphne Grabie

The Science Journal of the Lander College of Arts and Sciences

The gut microbiome, a diverse community of microorganisms within the gastrointestinal (GI) tract, plays a pivotal role in maintaining health through digestion, immune regulation, and homeostasis. Emerging evidence links gut microbiome dysbiosis—a disruption in its composition and function—to the development and progression of various cancers, particularly within the GI tract. This review explores the multifaceted relationship between the gut microbiome and carcinogenesis, highlighting key microbial mechanisms, including chronic inflammation, production of carcinogenic metabolites, and immune modulation. Specific pathogens such as Fusobacterium nucleatum, Escherichia coli, and Helicobacter pylori are implicated in colorectal, gastric, and esophageal cancers, respectively, through pathways that promote …

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Battling Infertility, Shirah Abrahams Jan 2025

Battling Infertility, Shirah Abrahams

The Science Journal of the Lander College of Arts and Sciences

Infertility is a complex condition that affects men and women equally and is defined by failure to achieve pregnancy after a year of trying to conceive. This paper addresses both environmental contributions to infertility, such as the effects of smoking, poor nutrition, and exposure to radiation, as well as biological contributors. Biological factors that contribute to infertility include sperm DNA fragmentation, chromosomal mutations, anovulatory dysfunction, and tubule blockages. This paper delves into various treatment options to improve fertility in both males and females, including medications, lifestyle adaptations, and surgeries. These treatment options can restore and improve ovulatory function, sperm motility …

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Mild Traumatic Brain Injury: Signs, Symptoms, And Intervention, Shoshana Levin Jan 2025

Mild Traumatic Brain Injury: Signs, Symptoms, And Intervention, Shoshana Levin

The Science Journal of the Lander College of Arts and Sciences

Mild traumatic brain injury (mTBI) is a specific type of brain injury, often referred to as a concussion. Relying on existing research, this paper will collect the data that is available on concussions, numerous methods of treatment, and the complications of repeated injury. mTBI precipitates a host of cognitive, physical, and emotional symptoms, all of which can severely affect one’s daily life if left untreated. This paper will also address a range of possible treatment methods, including but not limited to acupuncture, cognitive behavioral therapy, and physical therapy. The efficacy of a multifaceted approach to treatment is emphasized, combining opinions …

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Full Issue: Volume 18, Number 2, Spring 2025 Jan 2025

Full Issue: Volume 18, Number 2, Spring 2025

The Science Journal of the Lander College of Arts and Sciences

Complete .pdf file of Volume 18, Number 2 of The Science Journal of the Lander College of Arts and Sciences. Published Spring 2025.

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Can Cystic Fibrosis Be Treated With Genetic Therapy?, Steve Silverberg Jan 2025

Can Cystic Fibrosis Be Treated With Genetic Therapy?, Steve Silverberg

The Science Journal of the Lander College of Arts and Sciences

This paper discusses the current and prospective treatment options for the fatal genetic disease cystic fibrosis. Cystic fibrosis (CF) is a rare recessive genetic disorder that is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which codes for a protein that is on the surface of a cell. This protein allows for the flow of chloride, bicarbonate, and sodium ions to pass through the cell wall, bringing water with it. When this protein doesn’t work, the lack of ions and water in extracellular fluid becomes too thick, causing a multitude of problems. The most common …

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Implant Alternatives: The Advancements Of Stem Cells In Regenerative Dentistry, Akiva Goldschmidt Jan 2025

Implant Alternatives: The Advancements Of Stem Cells In Regenerative Dentistry, Akiva Goldschmidt

The Science Journal of the Lander College of Arts and Sciences

This research paper explores the potential of mesenchymal stem cells (MSCs) within the realm of dentistry, focusing particularly on their ability to repair tissues and regenerate entire teeth. MSCs are significant as they can send differentiation signals to nearby cells and release growth factors such as TGF-β and VEGF, which promote cellular activities necessary for dental repair and regeneration. The paper discusses the traditional methods of dental restoration, such as fillings and implants, and their inherent limitations. It then transitions to exploring innovative strategies that utilize MSCs to overcome these challenges and regenerate tooth structures including enamel, dentin, and periodontal …

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Full Issue: Volume 19, Number 1, Fall 2025 Jan 2025

Full Issue: Volume 19, Number 1, Fall 2025

The Science Journal of the Lander College of Arts and Sciences

Complete .pdf file of Volume 19, Number 1 of The Science Journal of the Lander College of Arts and Sciences. Published Fall 2025.

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Does Chronic Stress Play A Role In The Genesis Of Neurodegenerative Diseases?, Rachelle Halpert Jan 2025

Does Chronic Stress Play A Role In The Genesis Of Neurodegenerative Diseases?, Rachelle Halpert

The Science Journal of the Lander College of Arts and Sciences

Chronic stress has been increasingly recognized as a major contributor to the onset and progression of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. This paper explores the correlation between chronic stress and neurodegeneration by reviewing population, clinical, and animal studies. Studies show that long-term stress disrupts the hypothalamic-pituitary-adrenal (HPA) axis, impairs hippocampal function, increases oxidative stress, and promotes neuroinflammation. These processes are all implicated in cognitive decline. The mechanisms through which these processes occur are discussed including elevated glucocorticoid levels, shortened telomeres, mitochondrial dysfunction, and the activity of pro-inflammatory microglia. Lastly, potential interventions are reviewed, including lifestyle modifications such …

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Can Deadly Toxins Become Tools For Medicine?, Esther Gross Jan 2025

Can Deadly Toxins Become Tools For Medicine?, Esther Gross

The Science Journal of the Lander College of Arts and Sciences

Natural toxins, long feared as deadly poison, are increasingly being harnessed as powerful medicine. This paper explores the growing role of animal and plant toxins in modern medicine, tracing their use from ancient remedies to cutting-edge biomedical science. Through a study of their biochemical mechanisms, therapeutic applications, and clinical case histories, this paper draws attention to the remarkable specificity and potency of toxin-derived compounds for disease treatment in diabetes, chronic pain, cancer, cardiovascular disease, etc. This paper also investigates the scientific and practical barriers to the universal clinical application of toxins, such as issues of toxicity, cost, stability, and ethical …

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Endometriosis & Natural Killer Cell Activity, Orelle Shakarchi Jan 2025

Endometriosis & Natural Killer Cell Activity, Orelle Shakarchi

The Science Journal of the Lander College of Arts and Sciences

Endometriosis is a condition found in females of reproductive age. It occurs when tissue, known as the endometrium, grows outside of its designated place- the uterus. It affects the reproductive organs such as the ovaries, fallopian tubes, and pelvic tissues. Endometriosis patients experience chronic pain and fertility issues. There has been a correlation between low cytotoxicity in Natural Killer (NK) cells and the development of the disease. NK cells are part of the human innate immunity system where they defend the body against tumors and any abnormal cells by performing apostasies A study done by the American Fertility Society, which …

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Should Crispr Be Available As A Widespread Gene Therapy For Humans?, Mirel Leifer Jan 2025

Should Crispr Be Available As A Widespread Gene Therapy For Humans?, Mirel Leifer

The Science Journal of the Lander College of Arts and Sciences

The CRISPR/Cas gene editing tool was discovered in 2012 and since then has been researched extensively. It has many applications in the research and medical world and has been the topic of many discussions since its discovery. This paper describes several of the advantages of CRISPR; what it has been used for and the potential that it contains. Among those advantages are sickle cell treatment, Alzheimer’s treatment, coupling CRISPR with induced pluripotent stem cells(iPSCs), and the cancer battle. Also discussed in this paper are number of concerns that surround this new gene therapy. Among those are medical concerns and ethical …

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Does Prenatal Stress Have Prenatal And Life-Long Effects?, Miriam Lavizadeh Jan 2025

Does Prenatal Stress Have Prenatal And Life-Long Effects?, Miriam Lavizadeh

The Science Journal of the Lander College of Arts and Sciences

Maternal prenatal stress (MPS) has a unique impact on the developing fetus and the child’s life post birth. Pregnancy is a highly anxious time for a lot of women. Many have pregnancy related concerns as well as overall stress from environmental and societal factors. However, this takes a toll on the fetus’s development which can later cause different cognitive and health outcomes in the child. During a time of stress, one’s HPA axis gets activated causing the release of various hormones, particularly cortisol and catecholamines. These hormones can cross the placental barrier called HSD11B2-11β-hydroxysteroid dehydrogenase 2, exposing the sensitive and …

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The Role Of The Gut–Brain Axis In Irritable Bowel Syndrome, Malky Weiss Jan 2025

The Role Of The Gut–Brain Axis In Irritable Bowel Syndrome, Malky Weiss

The Science Journal of the Lander College of Arts and Sciences

The gastrointestinal (GI) system and the brain share a highly integrated relationship mediated by the gut–brain axis, with implications across a range of medical disciplines. Irritable bowel syndrome (IBS) is the most prevalent disorder of gut brain interaction (DGBI) which affects a significant portion of the global population, yet its pathophysiology has historically been poorly understood. This review examines the development and maintenance of IBS, drawing on literary sources to explore the gut–brain axis and disease expression which occurs as a result of its dysfunction. Common pathological features of IBS include visceral hypersensitivity, altered serotonin signaling, inappropriate immune activation, and …

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What Are The Long-Term Health Implications Of Living Kidney Donation?, Yehudis Fasten Jan 2025

What Are The Long-Term Health Implications Of Living Kidney Donation?, Yehudis Fasten

The Science Journal of the Lander College of Arts and Sciences

Living kidney donation is the optimal long-term treatment for patients with end-stage renal disease (ESRD), also known as end-stage kidney disease (ESKD). However, it also raises concerns regarding the long-term health of donors. This paper explores the potential risks that living kidney donors (LKDs) may face, focusing on the potential development of ESRD and post-donation pregnancy risks, especially in relation to established ESRD risk factors such as hypertension and diabetes mellitus. It also examines the impact of genetic and familial predispositions, structural kidney changes, and proteinuria as contributors to future decline in kidney function. Concerns including reductions in erythropoietin (EPO) …

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Implant Alternatives: The Advancements Of Stem Cells In Regenerative Dentistry, Akiva Goldschmidt Jan 2025

Implant Alternatives: The Advancements Of Stem Cells In Regenerative Dentistry, Akiva Goldschmidt

The Science Journal of the Lander College of Arts and Sciences

This research paper explores the potential of mesenchymal stem cells (MSCs) within the realm of dentistry, focusing particularly on their ability to repair tissues and regenerate entire teeth. MSCs are significant as they can send differentiation signals to nearby cells and release growth factors such as TGF-β and VEGF, which promote cellular activities necessary for dental repair and regeneration. The paper discusses the traditional methods of dental restoration, such as fillings and implants, and their inherent limitations. It then transitions to exploring innovative strategies that utilize MSCs to overcome these challenges and regenerate tooth structures including enamel, dentin, and periodontal …

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Novel Pharmacotherapies For Treatment-Resistant Depression: Lysergic Acid Diethylamide (Lsd), Eliana Cohen Jan 2025

Novel Pharmacotherapies For Treatment-Resistant Depression: Lysergic Acid Diethylamide (Lsd), Eliana Cohen

The Science Journal of the Lander College of Arts and Sciences

Treatment Resistant Depression has become extremely prevalent with 30% of depression cases being unresolvable. Psychedelics specifically Lysergic Acid Diethylamide has been a newfound unconventional approach that has demonstrated significant benefits for depression. LSD is a hallucinogenic drug mainly acting on the serotonin receptors that leads to altered sensory and perception affecting mood. This research paper comprehensively examines animal and human studies on LSD’s healing properties and enduring effects. The studies find that LSD induces neuroplasticity, and alters gene expressions associated with synaptogenesis and neurogenesis. Additionally LSD affects the activity of different neurotransmitters in the central nervous system enhancing mood. Lastly …

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Virtual Reality Cognitive Behavioral Therapy (Cbt) For Chronic Lower Back Pain, Peri Feinberg Jan 2025

Virtual Reality Cognitive Behavioral Therapy (Cbt) For Chronic Lower Back Pain, Peri Feinberg

The Science Journal of the Lander College of Arts and Sciences

No abstract provided.

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Embryonic Stem Cells Vs Induced Pluripotent Stem Cells For Tissue Engineering, Devora Weinstein Jan 2025

Embryonic Stem Cells Vs Induced Pluripotent Stem Cells For Tissue Engineering, Devora Weinstein

The Science Journal of the Lander College of Arts and Sciences

Both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are pluripotent, meaning that they can give rise to many types of cells. Consequently, they both represent incredible potential for applications in regenerative medicine and research models. This paper explores their similarities and critical molecular differences, especially in the context of tissue engineering. Through analysis of three peer-reviewed studies, the paper focuses on their respective advantages and limitations. One study used Raman spectroscopy to reveal higher nucleic acid content in iPSCs, possibly due to epigenetic memory. The second study utilized DNA methylation profiling and gene expression data to construct …

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Factors Mediating The Reproductive Risk For Balanced Chromosomal Translocation Carriers, Talia Alter Jan 2025

Factors Mediating The Reproductive Risk For Balanced Chromosomal Translocation Carriers, Talia Alter

The Science Journal of the Lander College of Arts and Sciences

Reciprocal balanced translocations occur when one part of a chromosome is exchanged with another, resulting in zero net loss of genetic material. While individuals with a balanced translocation are phenotypically normal, a translocation can cause increased risk of infertility, recurrent pregnancy loss, and the birth of a child with unbalanced chromosomes. In order to adequately guide an individual in their reproductive decisions, geneticists must be able to assess the risk of the patient’s unique translocation. An analysis of three recent studies reveals several factors which play a role in mediating the effects of balanced translocations and directly affect reproductive risk …

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Cytotoxic Constituents From Cylindrolobus Mucronatus Against Glioblastoma Cells, Shune Lae Yee Soe Jan 2025

Cytotoxic Constituents From Cylindrolobus Mucronatus Against Glioblastoma Cells, Shune Lae Yee Soe

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study reported the phytochemical investigation of Cylindrolobus mucronatus Lindl., a member of the Orchidaceae family, focusing on its chemical constituents and cytotoxic potential against glioblastoma cells. Eleven compounds were successfully isolated and structurally characterized, including new phenanthrene derivatives, cymucronins A-D, along with seven known compounds comprising confusarin , nudol, erianthridin, coelonin, bleformin I, (2,3-trans)-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-10-methoxy-2,3,4,5-tetrahydrophenanthro [2,1-b] furan-7-ol, and blestriarene C. Structural elucidation was accomplished using NMR, MS, IR and UV-Vis spectroscopic techniques, supported by comparison with literature data. Eight compounds were evaluated for their cytotoxic activity against U-87 human glioblastoma cells and three non-cancerous human cell lines: HEK293 (embryonic kidney), …

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การศึกษาความเต็มใจที่จะจ่ายในการรับเทคโนโลยีในการทำประมงพื้นบ้านในจังหวัดชลบุรี, ชนากานต์ ศุภศิริสมบัติ Jan 2025

การศึกษาความเต็มใจที่จะจ่ายในการรับเทคโนโลยีในการทำประมงพื้นบ้านในจังหวัดชลบุรี, ชนากานต์ ศุภศิริสมบัติ

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยนี้มีวัตถุประสงค์เพื่อประเมินมูลค่าความเต็มใจที่จะจ่ายในการรับเทคโนโลยีของชาวประมงพื้นบ้านในจังหวัดชลบุรี โดยใช้วิธีการประเมินมูลค่าภายใต้สถานการณ์สมมติ และศึกษาปัจจัยที่มีผลต่อ การกำหนดมูลค่าความเต็มใจที่จะจ่ายของชาวประมงพื้นบ้านในจังหวัดชลบุรีสำหรับการรับเทคโนโลยีเข้ามาช่วยในการทำประมงพื้นบ้านอย่างมีนัยสำคัญทางสถิติ โดยใช้แบบจำลอง Ordered Logistic Regression ในการวิเคราะห์ข้อมูล กลุ่มตัวอย่างของการศึกษา ได้แก่ ชาวประมงพื้นบ้านในจังหวัดชลบุรี จำนวน 454 คน และเทคโนโลยีที่ใช้ในการศึกษามี 3 ประเภท ได้แก่ เทคโนโลยีติดตามเรือประมง นวัตกรรมกระชังปลาอัจฉริยะ และนวัตกรรมอวนประมงติดหลอดไฟ LED จากผลการศึกษา พบว่า ตัวแปรที่ส่งผลต่อความเต็มใจที่จะจ่ายในการรับเทคโนโลยีในการทำประมงพื้นบ้านในจังหวัดชลบุรี โดยมีนัยสำคัญทางสถิติที่ระดับความเชื่อมั่นร้อยละ 95 ได้แก่ ตัวแปรระดับราคาที่เสนอครั้งแรก ระดับการให้ความสำคัญกับค่าใช้จ่ายในการบำรุงรักษาเครื่องมือที่ใช้ ในการทำประมงพื้นบ้าน ระดับการให้ความสำคัญกับการได้รับการสนับสนุนจากหน่วยงานภาครัฐ ระดับความรู้เรื่องเทคโนโลยีที่ประยุกต์ใช้ในเครื่องมือประมงพื้นบ้าน และระดับความรู้เรื่องการบำรุงรักษาเทคโนโลยีที่ประยุกต์ใช้ในเครื่องมือประมงพื้นบ้าน โดยมีข้อเสนอแนะเชิงนโยบายกับภาครัฐในด้านมาตรการส่งเสริมชาวประมงพื้นบ้านในการทำประมง ได้แก่ มาตรการการสนับสนุนผลิตภัณฑ์สัตว์น้ำทะเลคุณภาพ มาตรการ ให้เช่ายืมเครื่องมือและเทคโนโลยีในการทำประมงพื้นบ้าน มาตรการการรับรองสัตว์น้ำทะเลและส่งเสริมการตลาดสัตว์น้ำทะเลจากประมงพื้นบ้าน

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The Influence Of Butterbear Mascot Attractiveness On Brand Attitude, Huyen Phuong Do Jan 2025

The Influence Of Butterbear Mascot Attractiveness On Brand Attitude, Huyen Phuong Do

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research examines the influence of mascot’s perceived attractiveness on the brand attitude towards Butterbear. Data were collected via online survey from 220 male and female respondents (aged 18-26) residing in Bangkok, who had been exposed to content from Butterbear brand within the past three months. Overall, participants perceived Butterbear mascot as highly attractive (M = 4.39) and reported positive attitudes towards the Butterbear brand (M = 4.30). Furthermore, the findings revealed that all six dimensions underlying mascot attractiveness (Brand Impact, Brand Expertise, Mascot Uniqueness, Mascot Anthropomorphism, Mascot Intimacy, and Mascot Consistency) showed statistically significant correlations with the brand attitude. …

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Optimization Of Bioactive Compound Extraction From Rambutan Peels Using Pulsed Electric Field And Its Application, Robby Aji Prima Jan 2025

Optimization Of Bioactive Compound Extraction From Rambutan Peels Using Pulsed Electric Field And Its Application, Robby Aji Prima

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to optimize the extraction of bioactive compounds from rambutan peel using Pulsed Electric Field (PEF) technology and evaluate its functionality as a natural antioxidant. A Central Composite Design (CCD) was employed to examine the effects of ethanol concentration, electric field intensity, and pulse number on extraction efficiency. Response Surface Methodology (RSM) analysis revealed that the optimization model achieved a high composite desirability (D = 0.982). The optimal extraction conditions were identified as 70% ethanol, an electric field intensity of 4,000 V/cm, and 120 pulses. Under these conditions, the extract exhibited high levels of total phenolics, flavonoids, and …

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Neural-Network Based K-Value Prediction In Clustering Problems Without Distance Computation, Rohhan Rabari Jan 2025

Neural-Network Based K-Value Prediction In Clustering Problems Without Distance Computation, Rohhan Rabari

Chulalongkorn University Theses and Dissertations (Chula ETD)

Clustering remains a pivotal component of unsupervised learning, central to tasks such as data exploration and pattern discovery. However, most conventional clustering algorithms are parametric in nature, requiring one or more parameters to be specified in advance—most notably the number of clusters (k). These predefined parameters can drastically alter the outcome of clustering, leading to unstable or misleading results, particularly when the true structure of the data is unknown. This thesis introduces a novel framework that transforms raw input into a latent vector representation, enabling a neural network to automatically predict the optimal number of clusters without any prior parameter …

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Production Of Graphene From Graphite Via Flash Joule Heating Process, Siranut Sirathanutworakan Jan 2025

Production Of Graphene From Graphite Via Flash Joule Heating Process, Siranut Sirathanutworakan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Graphene is a material with unique properties and high potential. Due to its outstanding characteristics in strength, electrical and thermal conductivity, and flexibility, graphene is considered one of the materials of the future that can be used to enhance the efficiency of various emerging technologies. This research focuses on the synthesis of graphene using the Flash Joule Heating (FJH) process, during which an extremely high temperature occurs within milliseconds. The carbon precursor is rapidly exposed to intense heat, resulting in the dissociation of all chemical bonds in its structure and the reorganization of carbon atoms into a new graphene structure. …

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Data-Driven Predictive Model For Various Shapes Of Gold Nanoparticle Synthesis Based On Self-Organizing Maps, Thanapol Khamhla Jan 2025

Data-Driven Predictive Model For Various Shapes Of Gold Nanoparticle Synthesis Based On Self-Organizing Maps, Thanapol Khamhla

Chulalongkorn University Theses and Dissertations (Chula ETD)

This work presents a machine learning framework that simultaneously classifies the shape and predicts the localised surface plasmon resonance (LSPR) wavelength of gold nanoparticles (AuNPs) purely from synthesis conditions. The dataset used to train the model consist of synthesis conditions and the corresponding AuNPs characteristics, including spherical, star, plate, and rod shapes with their measured LSPR wavelengths, were compiled from existing literatures. Our model first classifies synthesis conditions into clusters according to their resulting shape and then builds local regression models for each shape, enabling both classification and quantitative prediction within a single framework. The proposed model integrates the clustering …

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Functional Characterization Of Vago In Black Tiger Shrimp Penaeus Monodon Ikk-Nf-Κb Signaling Pathway Against Viral Infection, Zittipong Nanakorn Jan 2025

Functional Characterization Of Vago In Black Tiger Shrimp Penaeus Monodon Ikk-Nf-Κb Signaling Pathway Against Viral Infection, Zittipong Nanakorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cytokines serve as key regulators in innate antiviral defense. In crustaceans, research on cytokine-mediated immunity remains limited. A previous study in Penaeus monodon has demonstrated that PmVago proteins exhibit cytokine-like function by acting through the inhibitor of kappa B kinase-nuclear factor κB (IKK-NF-κB) cascade to defend against white spot syndrome virus (WSSV). In this study, five PmVago isoforms were identified, each showing differential transcriptional responses to pathogen challenges. Among them, PmVago1 and PmVago4 exhibited strong antiviral responses against WSSV infection. RNA interference of PmVago1 and PmVago4 increased shrimp susceptibility to WSSV infection with enhanced viral replication. Their suppression also disrupted …

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