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Classical Guidance Model With Problem-Based Learning Technique To Improve Students' Empathy In Inclusive State Junior High School In Yogyakarta, Novira Silmi Sabila, Budi Astuti, Moch Arifudin

Journal of ICSAR

Inclusive schools have an important role in creating a friendly educational environment for all students, including those with special needs. One important aspect in creating an inclusive school is increasing empathy of regular students towards their friends with special needs. This study aims to develop and test the feasibility and practicality of the classical guidance model with problem-based learning techniques to increase regular students' empathy towards children with special needs in guidance and counseling services at 10 Inclusive State Junior High Schools in Yogyakarta. This research is research and development with the Borg & Gall model with 7 stages: (1) …

Development Of 'Me And You' Model For Emotional And Behavioral Disorders In Children: A Joyful Approach, Siti Nuraini Purnamawati, Hartini Nara, Rohmah Ageng Mursita, Lintang Al Mar’Atus Sholihah

Journal of ICSAR

This research focuses on the development of the "Me and You" learning model for children with emotional and behavioral disorders (EBD), especially those from socioeconomically disadvantaged environments, such as the Rusunawa Jatinegara Kaum area in East Jakarta. Using the ADDIE model (Analysis, Design, Development, Implementation, Evaluation), the study employed a systematic, evidence-based approach to create and refine an effective educational intervention. The model, organized around five core themes addressing self-awareness, emotional regulation, and social interaction, aims to reduce misunderstandings and foster positive peer relationships. The intervention was tested in a community setting, and expert validation was conducted. Findings suggest that …

Recasting Gender Roles: A Study Of Indian Television Commercials (2011– 2020), Himika Akram, Alicia Mason

Faculty Submissions

On media, television commercials (TVCs) play a significant role in shaping societal perceptions of gender roles. This study examines gender depictions in Indian TVCs, focusing on key dimensions such as gender ratio in primary characters, voiceovers, settings (home, outdoor, workplace), and product categories. A content analysis of 120 TVCs from Indian brands (2011–2020) was conducted, with coding performed by the researcher. Findings reveal that men were primary characters in 54.6% of the advertisements, while women featured in 45.4%. Male voiceovers dominated at 70.1%, compared to 29.9% for females. Women were portrayed in home settings in 66.7% of TVCs, while men …

First In Time Since Time Immemorial: Tribal Instream Rights Undercut Water Taking Claims, Paul Stanton Kibel, L. Victoria Wang

American Indian Law Journal

Courts have held that American Indian tribal fishery rights can give rise to tribal instream flow rights. They have also held that the curtailment of rights of diversion to protect fisheries under the Federal Endangered Species Act may give rise to potential takings claims under the Fifth Amendment of the United States Constitution. In its 2019 decision in Baley v. United States the federal circuit court of appeals held that minimum instream flows under the ESA were needed to fulfill American Indian tribal fishery rights, and these rights carried a priority date of “time immemorial” that was senior to any …

Intravaginal Cooling Provides Symptom Relief In Women With Vulvovaginal Candidiasis And Reduces Immunopathology In An Accompanying Mouse Model, Junko Yano, Kimberly Langdon, Michael Swor, Mairi C. Noverr, Paul L. Fidel

School of Dentistry Faculty Publications

BACKGROUND: Vulvovaginal candidiasis (VVC), caused primarily by Candida albicans, is currently treated with either prescription or over-the-counter antifungal drugs, often with variable efficacy and relapses. New and improved therapeutic strategies, including drug-free treatment alternatives, are needed. Upon overgrowth or environmental triggers, C. albicans yeast transitions into hyphae that results in an aberrant immunopathologic response by neutrophils, contributing to the characteristic vulvovaginal symptoms. The purpose of this study was to evaluate the efficacy of a patented intravaginal cooling device (Vlisse®) to provide symptom relief in women with VVC via putative reversal of C. albicans hyphae to the commensal yeast form, with …

Jordanian Women's Perception Of The Discrepancy Between Education And Access To Labor Market, Rana El Khawand

Walden Dissertations and Doctoral Studies

This study is an examination of the perceptions of educated Jordanian women regarding the gap between their high educational attainment and limited access to the labor market, focusing on systemic sociocultural, institutional, and economic barriers. Targeting women in science, technology, engineering, and mathematics (STEM) fields, the study was conducted using a feminist theoretical framework emphasizing societal norms, power imbalances, and institutional inequities as critical factors shaping women’s professional experiences. A generic qualitative design was employed, collecting data through semistructured interviews and SenseMaker narratives from four faculty members at a Jordanian university. Thematic coding, discourse analysis, and sentiment analysis were used …

Jordanian Women's Perception Of The Discrepancy Between Education And Access To Labor Market, Rana El Khawand

Walden Dissertations and Doctoral Studies

This study is an examination of the perceptions of educated Jordanian women regarding the gap between their high educational attainment and limited access to the labor market, focusing on systemic sociocultural, institutional, and economic barriers. Targeting women in science, technology, engineering, and mathematics (STEM) fields, the study was conducted using a feminist theoretical framework emphasizing societal norms, power imbalances, and institutional inequities as critical factors shaping women’s professional experiences. A generic qualitative design was employed, collecting data through semistructured interviews and SenseMaker narratives from four faculty members at a Jordanian university. Thematic coding, discourse analysis, and sentiment analysis were used …

Lipid Nanoparticles Deliver Dna-Encoded Biologics And Induce Potent Protective Immunity, Dafei Chai, Junhao Wang, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H Young, Yong Li

Faculty, Staff and Students Publications

Lipid nanoparticles (LNPs) for mRNA delivery have advanced significantly, but LNP-mediated DNA delivery still faces clinical challenges. This study compared various LNP formulations for delivering DNA-encoded biologics, assessing their expression efficacy and the protective immunity generated by LNP-encapsulated DNA in different models. The LNP formulation used in Moderna's Spikevax mRNA vaccine (LNP-M) demonstrated a stable nanoparticle structure, high expression efficiency, and low toxicity. Notably, a DNA vaccine encoding the spike protein, delivered via LNP-M, induced stronger antigen-specific antibody and T cell immune responses compared to electroporation. Single-cell RNA sequencing (scRNA-seq) analysis revealed that the LNP-M/pSpike vaccine enhanced CD80 activation signaling …

Uncovering The Binding Mechanism Of Mutated Omicron Variants Via Computational Strategies, Sajjad Haider, Nadeem Ahmad, Muhammad Shafiq, Ali Raza Siddiqui, Mohammad Nur-E-Alam, Aftab Ahmed, Zaheer Ul-Haq

Pharmacy Faculty Articles and Research

The COVID-19 pandemic, triggered by the SARS-CoV-2 virus, has resulted in nearly 630 million cases and 6.60 million fatalities globally, as of November 2022. SARS-CoV-2, a species of the Coronaviridae family, has a single-stranded positive-sense RNA genome as well as four main structural proteins (S, E, M, and N) required for viral entrance into target cells. The spike protein (S) influences this entry through interactions with human angiotensin-converting enzyme 2 (hACE2) receptor. The World Health Organization (WHO) recognized numerous variants of concern (VOCs) that involve Alpha, Beta, Gamma, Delta, and Omicron, having multiple mutations within the spike protein, altering infection …

Identification And Characterization Of A Novel Pavlovskyella (Acari: Argasidae) From Chile, Parasite Of The Culpeo Fox (Lycalopex Culpaeus), Sebastián Muñoz-Leal, Alexander R Kneubehl, Karen Ardiles, Catalina Parragué-Migone, Ignacio Troncoso-Toro, Pablo Oyarzún-Ruiz, Job E Lopez

Faculty, Staff and Students Publications

Soft ticks (Argasidae) of the subgenus Pavlovskyella Pospelova-Shtrom are worldwide distributed parasites of medical importance. However, the systematics of the subgenus are currently under debate because genetic data shows that the group is paraphyletic. Meanwhile, species of Pavlovskyella continue to be discovered. In this study a novel species of the subgenus is described from specimens collected on a fox in central Chile. The larva of this new species differentiates from other Pavlovskyella spp. by having the following combination of characters: subpyriform dorsal plate; 15 pairs of setae, 7 anterolateral, 3 central, and 5 posterolateral, and hypostome with denticles in the …

Neutrophil Extracellular Traps Promote Pre-Metastatic Niche Formation In The Omentum By Expanding Innate-Like B Cells That Express Il-10, Wonjae Lee, Song Yi Ko, Hironari Akasaka, Melanie Weigert, Ernst Lengyel, Honami Naora

Faculty, Staff and Student Publications

Disseminated cancer cells in the peritoneal fluid often colonize omental fat-associated lymphoid clusters but the mechanisms are unclear. Here, we identify that innate-like B cells accumulate in the omentum of mice and women with early-stage ovarian cancer concomitantly with the extrusion of chromatin fibers by neutrophils called neutrophil extracellular traps (NETs). Studies using genetically modified NET-deficient mice, pharmacologic inhibition of NETs, and adoptive B cell transfer show that NETs induce expression of the chemoattractant CXCL13 in the pre-metastatic omentum, stimulating recruitment of peritoneal innate-like B cells that in turn promote expansion of regulatory T cells and omental metastasis through producing …

Integrating Priorities At The Intersection Of Cancer And Neuroscience, William L Hwang, Ella N Perrault, Alexander Birbrair, Brandi J Mattson, David H Gutmann, Donald J Mabbott, Edna Cukierman, Elizabeth A Repasky, Erica K Sloan, Hui Zong, Ihsan Ekin Demir, Jami L Saloman, Jeremy C Borniger, Jian Hu, Jorg Dietrich, Joshua J Breunig, Kaan Çifcibaşı, Khalil Ali Ahmad Kasm, Manuel Valiente, Max Wintermark, Munjal M Acharya, Nicole N Scheff, Nisha J D'Silva, Paola D Vermeer, Richard J Wong, Sebastien Talbot, Shawn L Hervey-Jumper, Timothy C Wang, Yi Ye, Yuan Pan, Yuri L Bunimovich, Moran Amit

Faculty, Staff and Student Publications

Cancer neuroscience is a rapidly growing multidisciplinary field that conceptualizes tumors as tissues fully integrated into the nervous system. Recognizing the complexity and challenges in this field is of fundamental importance to achieving the goal of translational impact for cancer patients. Our commentary highlights key scientific priorities, optimal training settings, and roadblocks to translating scientific findings to the clinic in this emerging field, aiming to formulate a transformative and cohesive path forward.

Nerves At Play: The Peripheral Nervous System In Extracranial Malignancies, Paola D Vermeer, Anthony C Restaino, Jeffrey L Barr, Dan Yaniv, Moran Amit

Faculty, Staff and Student Publications

The exponential growth of the cancer neuroscience field has shown that the host's immune, vascular, and nervous systems communicate with and influence each other in the tumor microenvironment, dictating the cancer malignant phenotype. Unraveling the nervous system's contributions toward this phenotype brings us closer to cancer cures. In this review, we summarize the peripheral nervous system's contributions to cancer. We highlight the effects of nerve recruitment and tumor innervation, the neuro-immune axis, glial cell activity, and neural regulation on cancer development and progression. We also discuss harnessing the neural control of peripheral cancers as a potential therapeutic approach in oncology. …

Combined Kras Inhibition And Immune Therapy Generates Durable Complete Responses In An Autochthonous Pdac Model, Yonghong Liu, Jincheng Han, Wen-Hao Hsu, Kyle A Labella, Pingna Deng, Xiaoying Shang, Paulino Tallón De Lara, Li Cai, Shan Jiang, Ronald A Depinho

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) resists conventional chemo/radiation and immunotherapy. In PDAC, oncogenic KRAS (KRAS*) drives glycolysis in cancer cells to consume available glucose and produce abundant lactate, creating profound immune suppression in the tumor microenvironment. Here, we combined KRAS* inhibition with agents targeting the major arms of the immunity cycle: CXCR1/2 inhibitor for myeloid cells, antagonistic anti-LAG3 antibody for T cells, and agonistic anti-41BB antibody for dendritic cells. This combination elicited robust anti-tumor regression in iKPC mice bearing large autochthonous tumors. While untreated mice succumbed within 3 weeks, sustained treatment led to durable complete tumor regression and prolonged survival in …

Economic Evaluations Of Artificial Intelligence Implementation In Diabetic Retinopathy Screening, Ahmad Ahmad, Neily Zakiyah, Auliya A. Suwantika

Pharmacology and Clinical Pharmacy Research

Diabetic retinopathy (DR) is a common complication of diabetes that damages retinal blood vessels and can lead to vision impairment. The application of Artificial Intelligence (AI) in DR screening offers a promising alternative to conventional methods. However, further research is crucial to determine the cost-effectiveness of this intervention.This study systematically reviewed economic evaluations of AI interventions in DR screening using data from PubMed and ScienceDirect (2014–2023). Studies in various healthcare settings assessing cost-effectiveness outcomes, such as incremental cost-effectiveness ratio (ICER) and net monetary benefit, were included. The CHEERS (Consolidated Health Economic Evaluation Reporting Standards) checklist was used to assess the …

Soil Residual Activity Of Tetflupyrolimet And The Influence Of Soil Moisture And Flood Timeliness On Barnyardgrass Efficacy, Mason C. Castner, Jason K. Norsworthy, Trenton L. Roberts, Travis R. Faske, Thomas R. Butts, Nick R. Bateman

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Tetflupyrolimet is the first herbicide with a novel site of action to be commercialized for use in agronomic crops in three decades. Direct-seed rice field experiments were conducted at research facilities near Stuttgart (silt loam), AR, and Keiser (clay), AR, to evaluate tetflupyrolimet as a preemergence herbicide versus commercial standards. Greenhouse experiments determined the influence of soil moisture on pre- and postemergence barnyardgrass control with tetflupyrolimet and clomazone and the impact of a delayed flood on efficacy when POST-applied. For the field experiments, clomazone, tetflupyrolimet, and quinclorac were applied individually PRE at 336 and 560, 134 and 224, and 336 …

Soluble Herpes Virus Entry Mediator And Type Ii/Iii Interferons Are Upregulated In Primary Biliary Cholangitis, Yooyun Chung, Hio Lam Phoebe Tsou, Michael A Heneghan, Shilpa Chokshi, Antonio Riva

Peninsula Medical School

Bacterial translocation-induced inflammation and immune dysfunction are recognised factors contributing to the pathogenesis of primary biliary cholangitis (PBC). However, the specific involvement of interferons (IFNs) and soluble checkpoints (sol-CRs) in shaping the immune landscape in PBC patients remains unexplored. Furthermore, the influence of ursodeoxycholic acid (UDC) on these immune mediators is unknown. Twenty-eight cytokines and 14 sol-CRs were quantified by Luminex assays in plasma samples from 64 PBC patients and 10 healthy controls (HCs). D-lactate was measured as a marker of bacterial translocation. The PBC subgroups were: 24 UDC responders (UDCRs), 18 UDC non-responders (UDCNRs) and 22 patients with end-stage …

Root Decomposition And Nutrient Dynamics In Multifunctional Forage-Biomass Buffer-Strip Systems, Helen C.S. Amorium, Amanda J. Ashworth, Taylor C. Adams, Mary C. Savin, Philip A. Moore Jr

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Perennial crops are thought as a solution for enhancing food security and providing ecosystem services under a changing climate, including forage-biomass production, reduced erosion and nutrient leaching, and soil C accumulation. However, the drivers of root decomposition and C allocation in perennial multifunctional forage-biomass buffer-strips as affected by fertility management are poorly elucidated. Thus, study objectives were to assess root decomposition and soil CO2 efflux on switchgrass (Panicum virgatum L.), eastern gamagrass (Tripsacum dactyloides L.), silphium (Silphium integrifolium Michx.), and intermediate wheatgrass Kernza (Thinopyrum intermedium [Host] Barkworth & D.R. Dewey) treated with poultry litter (PL) relative to the unfertilized control. …

Not My Daughter: The Symbolic American Child And Cinematic Potential, Jacob Campbell

CLAMANTIS: The MALS Journal

No abstract provided.

Performance Of Eight Lettuce Cultivars In A Water Culture System, Ricky C. Young, Hudson M. Cox, Jacob D. Frodge, Mollie K. Mayabb, Brycen C. Shephard, Alireza Rahemi

Posters-at-the-Capitol

Lettuce (Lactuca sativa L.) is one of the most well-known vegetables in the world. About 27 million tons of lettuce were produced in the world in 2022 and global demand for lettuce is increasing steadily, driven by the importance of fiber consumption. Lettuce can be grown in multiple media, including hydroponic systems in a controlled environment agriculture (CEA) system. Growing lettuce in hydroponic systems is an alternative to lettuce production optimization. Since little information is available about lettuce cultivar trials in hydroponic systems, a research project was developed and executed to study the ability of different types of lettuce …

Intermediate And Middle Bronze Age Settlement Remains, Domestic Worship, Pits And Burial Practices In Nahal RefaʼIm, Jerusalem, Shlomit Weksler-Bdolah, Alexander Onn

'Atiqot

Excavations on the northern bank of the Refa’im Valley uncovered four sites: a shaft tomb and building remains with a standing stone dating to the Intermediate Bronze Age; a concentration of eight pits dating to the Intermediate Bronze Age and the Middle Bronze Age II; and an Ottoman-period agricultural watchtower. The building remains and installations were probably part of the Intermediate Bronze Age settlement along Naḥal Refa’im. The standing stone’s prominent location, and the large concentration of pits and installations near it, may support its identification with domestic worship. The thin fill at the bottom of some of the pits …

Figurines And Their Makers: A View From A Canaanite Cultic Enclosure At Tel Burna, Jon Ross, Itzhaq Shai

'Atiqot

Plaque figurines are a well-established Canaanite tradition of the Late Bronze Age Southern Levant. In this paper, we go beyond typology to consider who made these ritual objects at Tel Burna, based on impressions of fingerprints from shaping these figurines using an open mold. The lack of care exhibited on the backs and sides of the plaques has enabled a fingerprint analysis using proven biometric methods to clarify the demographics of their producers and the division of labor. Such analyses, when possible, potentially add another dimension to existing debates over how these cultic objects functioned in society, who made them …

Chromosome 4 Duplication Associated With Strabismus Leads To Gene Expression Changes In Ipsc-Derived Cortical Neurons., Mayra Martinez-Sanchez, William C Skarnes, Ashish Jain, Sampath Vemula, Liang Sun, Shira Rockowitz, Mary C Whitman

Faculty Research 2025

BACKGROUND/OBJECTIVES: Strabismus is the most common ocular disorder of childhood. Three rare, recurrent genetic duplications have been associated with both esotropia and exotropia, but the mechanisms by which they contribute to strabismus are unknown. This work aims to investigate the mechanisms of the smallest of the three, a 23 kb duplication on chromosome 4 (hg38|4:25,554,985-25,578,843).

METHODS: Using CRISPR and bridging oligos, we introduced the duplication into the Kolf2.1J iPSC line. We differentiated the parent line and the line with the duplication into cortical neurons using a three-dimensional differentiation protocol, and performed bulk RNASeq on neural progenitors (day 14) and differentiated …

Is Modulation Of Immune Checkpoints On Glioblastoma-Infiltrating Myeloid Cells A Viable Therapeutic Strategy?, Ruochen Du, Jianzhong Zhang, Rimas V Lukas, Shashwat Tripathi, Jared T Ahrendsen, Michael A Curran, Crismita Dmello, Peng Zhang, Roger Stupp, Ganesh Rao, Amy B Heimberger

Faculty, Staff and Students Publications

The field of immunology has traditionally focused on immune checkpoint modulation of adaptive immune cells. However, many malignancies such as glioblastoma are mostly devoid of T cells and rather are enriched with immunosuppressive myeloid cells of the innate immune system. While some immune checkpoint targets are shared between adaptive and innate immunity, myeloid-specific checkpoints could also serve as potential therapeutics. To better understand the impact of immune checkpoint blockade on myeloid cells, we systematically summarize the current literature focusing on the direct immunological effects of PD-L1/PD-1, CD24/Siglec-10, collagen/LAIR-1, CX3CL1/CX3CR1, and CXCL10/CXCR3. By synthesizing the molecular mechanisms and the translational implications, …

Regions Of Risk: A Geographical Introduction To Disasters By Kenneth Hewitt, Taly D. Drezner

The Geographical Bulletin

Regions of Risk is a comprehensive text that painstakingly describes how disasters and the threat of disasters shape and geographically alter communities and regions all over the world. In his introduction, Hewitt writes, "Any given risk or disaster event is distinguished by its geographic location and setting. These are important keys to the origins of danger, the forms of damage and whom they most affect."

Exploring Geographic Information Systems By Nicholas Chrisman, Eric Matranga

The Geographical Bulletin

Rather than attempting to define the bounds and scope of geographic information, Chrisman provides an organizational framework that" . .. challenges the reader to participate in the exploration". Exploring Geographic Information Systems uses a nested set of interrelated issues to emphasize the need for users to think critically about the appropriate use of methods, tools, and data in GIS.

Physical Hydrology By S. Lawrence Ding-Man, Patricia J. Beyer

The Geographical Bulletin

As the public eye increasingly focuses on issues related to the use and quality of water, the science of hydrology expands from its position as an academic and engineering endeavor to one of prominance in people's everyday lives. With this expansion comes the need for education, not only for hydrologists and geomorphologists, but for biologists, botanists, earth scientists, climatologists, land managers, developers and policy makers. Water is a fascinating and complex substance: not only is water itself a resource, but it is also a main pathway for energy and chemical transfer in the Earth-atmosphere system.

Environmental Geography: Science, Land Use, And Earth Systems By William M.Marsh And John M. Grossa, Eric Matranga

The Geographical Bulletin

Environmental Geography is an introductory text for undergraduate instruction. Marsh and Grossa recognize a lack of geographic perspectives in such texts. They set as their task, building "on the traditional themes of geography". Concepts covered include environmental systems, principles of space, scale and distributions, and landscape as the result of human-environment interaction.

Contemporary Europe: A Geographic Analysis. (7th Edition) By William H. Berent-Sen, Editor, Wendy Shaw

The Geographical Bulletin

Europe is a continent characterized by great complexity both physically and culturally. It is a fascinating place steeped in history yet seemingly in a state of con - stant flux. The region provides a challenge to authors who endeavor to present a comprehensive view of Europe. This book targets students in introductory col - lege courses and focuses on contemporary Europe. Each chapter has a different author, writing style, approach, and struc - ture that reflects that author's area of in - terest and expertise. Chapters are in - cluded that are topically focused such as those on population and …

А Review Of Scorpiofauna Of China: Nomenclatural Notes And Updated Faunistic Catalogue (Arachnida: Scorpiones), Victoria Tang

Euscorpius

Two genera associated with the Chinese scorpiofauna are reviewed, Razianus Farzanpay, 1987 and Reddyanus Vachon, 1972. Holotype female of Razianus xinjianganus Lourenço et al., 2010 is presumed to be lost, as well as all type material of other Chinese scorpions described before 2020. Comments are given on the species composition of genus Reddyanus with a new synonym: Isometrus (Reddyanus) tibetanus Lourenço & Zhu, 2008 = Reddyanus assamensis (Oates, 1888) syn. n. Reddyanus kanak Lourenço, 2023 is tentatively considered as a nomen dubium. An updated catalogue of Chinese scorpiofauna is provided, including their type locality and type depository, protonym, synonym(s), …