Digital Commons Network^™

Quantifying Dust Nutrient Mobility Through An Alpine Watershed, Jeffrey R. Nielson, Janice Brahney

Watershed Sciences Faculty Publications

Dust has the potential to play a significant role in the nutrient dynamics of alpine watersheds with important ecological implications. However, little is known about how dust nutrients circulate through the environment and which watershed characteristics facilitate dust impacts on water quality. This study explored the contribution of dust-deposited nutrients, focusing on a high-elevation Long Term Ecological Research site, where dust samples have been continuously collected since 2017. We incorporated observed dust nutrient compositions, including fractions of inorganic and organic nitrogen and phosphorus, into a popular hydrological model, the Soil and Water Assessment Tool, and ran simulations for 2019–2021. By …

Minerals And Human Health: From Deficiency To Toxicity, Mohammed S. Razzaque, Sunil J. Wimalawansa

School of Medicine Publications

Minerals are essential nutrients that play critical roles in human health by regulating various physiological functions. Examples include bone development, enzyme function, nerve signaling, and the immune response. Both the deficiencies and toxicities of minerals can have significant health implications. Deficiencies in macrominerals such as calcium, magnesium, and phosphate can lead to osteoporosis (associated with falls and fractures), cardiovascular events, and neuromuscular dysfunction. Trace mineral deficiencies, such as iron and zinc. Selenium deficiency impairs oxygen transport, immune function, and antioxidant defenses, contributing to anemia, delaying wound healing, and increasing susceptibility to infectious diseases. Conversely, excessive intake of minerals can have …

Sigma1 Inhibitor Suppression Of Adaptive Immune Resistance Mechanisms Mediated By Cancer Cell Derived Extracellular Vesicles, Paola A. Castagnino, Derick A. Haas, Luca Musante, Nathalia A. Tancler, Bach V. Tran, Rhonda Kean, Alexandra R. Steck, Luis A. Martinez, Elahe A. Mostaghel, D. Craig Hooper, Felix J. Kim

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Adaptive immune resistance in cancer describes the various mechanisms by which tumors adapt to evade anti-tumor immune responses. IFN-γ induction of programmed death-ligand 1 (PD-L1) was the first defined and validated adaptive immune resistance mechanism. The endoplasmic reticulum (ER) is central to adaptive immune resistance as immune modulatory secreted and integral membrane proteins are dependent on ER. Sigma1 is a unique ligand-regulated integral membrane scaffolding protein enriched in the ER of cancer cells. PD-L1 is an integral membrane glycoprotein that is translated into the ER and processed through the cellular secretory pathway. At the cell surface, PD-L1 is an immune …

Influence Of High Eimeria Tenella Immunization Dosages On Total Oocyst Output And Specific Antibodies Recognition Response In Hybrid Pullets (Gallus Gallus)-A Pilot Study, Marco A. Juarez-Estrada, Guillermo Tellez-Isaias, Victor M. Petrone-Garcia, Amanda Gayosso-Vazquez, Xochitl Hernandez-Velasco, Rogelio A. Alonso-Morales

Political Science Faculty Publications and Presentations

Background: Two high primary-immunization doses of a wild-type E. tenella strain were assessed in healthy pullets (5K versus 10K sporulated oocysts/bird) to understand the effects of coccidia infection. Methods: Acquired immunity was evaluated following primary immunization and two booster doses with the homologous strain. Total oocyst shedding, clinical signs, and viability of every bird/group after each immunization/booster were recorded. Indirect ELISA measured the time course of humoral responses from each immunization group against sporozoite and second-generation merozoite of E. tenella. Antigen pattern recognition on these two asexual zoite stages of E. tenella was analyzed using Western blotting with antibodies from …

Genome-Wide Profiling Of Trna Modifications By Induro-Trnaseq Reveals Coordinated Changes, Yuko Nakano, Howard Gamper, Henri Mcguigan, Sunita Maharjan, Jiatong Li, Zhiyi Sun, Erbay Yigit, Sebastian Grünberg, Keerthana Krishnan, Nan-Sheng Li, Joseph Piccirilli, Ralph Kleiner, Nicole Nichols, Brian Gregory, Ya-Ming Hou

Department of Biochemistry and Molecular Biology Faculty Papers

While all native tRNAs undergo extensive post-transcriptional modifications as a mechanism to regulate gene expression, mapping these modifications remains challenging. The critical barrier is the difficulty of readthrough of modifications by reverse transcriptases (RTs). Here we use Induro-a new group-II intron-encoded RT-to map and quantify genome-wide tRNA modifications in Induro-tRNAseq. We show that Induro progressively increases readthrough over time by selectively overcoming RT stops without altering the misincorporation frequency. In a parallel analysis of Induro vs. a related RT, we provide comparative datasets to facilitate the prediction of each modification. We assess tRNA modifications across five human cell lines and …

Development And Characterization Of Cd44-Targeted X-Aptamers With Enhanced Binding Affinity For Cancer Therapeutics, Hongyu Wang, Weiguo He, Miguel-Angel Elizondo-Riojas, Xiaobo Zhou, Tae Jin Lee, David G Gorenstein

Faculty, Staff and Student Publications

CD44, a pivotal cell surface molecule, plays a crucial role in many cellular functions, including cell-cell interactions, adhesion, and migration. It serves as a receptor for hyaluronic acid and is involved in lymphocyte activation, recirculation, homing, and hematopoiesis. Moreover, CD44 is a commonly used cancer stem cell marker associated with tumor progression and metastasis. The development of CD44 aptamers that specifically target CD44 can be utilized to target CD44-positive cells, including cancer stem cells, and for drug delivery. Building on the primary sequences of our previously selected thioaptamers (TAs) and observed variations, we developed a bead-based X-aptamer (XA) library by …

Statistical Identification Of Cell Type-Specific Spatially Variable Genes In Spatial Transcriptomics, Lulu Shang, Peijun Wu, Xiang Zhou

Faculty, Staff and Student Publications

An essential task in spatial transcriptomics is identifying spatially variable genes (SVGs). Here, we present Celina, a statistical method for systematically detecting cell type-specific SVGs (ct-SVGs)-a subset of SVGs exhibiting distinct spatial expression patterns within specific cell types. Celina utilizes a spatially varying coefficient model to accurately capture each gene's spatial expression pattern in relation to the distribution of cell types across tissue locations, ensuring effective type I error control and high power. Celina proves powerful compared to existing methods in single-cell resolution spatial transcriptomics and stands as the only effective solution for spot-resolution spatial transcriptomics. Applied to five real …

Demetrius Boyd

African American Funeral Programs

Demetrius_Boyd.pdf - Funeral program for Demetrius Boyd

The Evolving Coast By Richard A. Davisjr, C. Nicholas Raphael

The Geographical Bulletin

The most obvious and attractive boundary to people is that which separates the land from the sea. Although shorelines have been examined and classified since the early part of this century (e.g. Gulliver, 1899: Suess, 1909), understanding of their hazards and the consequence of reckless development seems, until quite recently, to have passed us by.

The Right To Receive Information: Conceptual Problems, Shrutanjaya Bhardwaj Mr

Indian Journal of Law and Technology

This article studies the “right to receive information” or the “right to know”, a judicially-recognised right under Article 19(1)(a) of the Constitution. It attempts to show, through an analysis of judgments of the Supreme Court and High Courts, that the right rests on a shaky philosophical foundation and that there are inconsistencies in how the right is judicially treated in terms of its structure and content.

First, the article questions the logic that the “right to know” is implicit in Article 19(1)(a) merely because it makes the exercise of free speech more meaningful. Such a logic was authoritatively rejected by …

Social Jetlag Alters Markers Of Exercise-Induced Mitochondrial Adaptations In The Heart, Michael B. Dial, Elias M. Malek, Austin R. Cooper, Greco A. Neblina, Nikoleta I. Vasileva, Graham Mcginnis

Kinesiology and Nutrition Sciences Faculty Research

Social jetlag (SJL) represents the behavioral misalignment of sleep and wake times on work days and free days, and potently disrupts the circadian rhythm. SJL affects up to 70% of the population worldwide and is associated with increased risk for many cardiometabolic diseases. Animal models of acute SJL have shown disruption in locomotor activity and expression of clock genes in select tissues, its impact on the heart remains unclear. The purpose of this study was to investigate the effects of prolonged SJL (6 weeks), on activity rhythms, and the impact on exercise-induced adaptations in the heart. Male mice (n …

Contemporary Views Of Spiritual And Theological Reflection (2013-2023) Compared To Forty Years Ago: Analysis Of 32 Texts, Chris Brouillard-Coyle, Des Mcenaney, Joselin Zak, Thomas St. James O’Connor

Consensus

What are contemporary views on spiritual and theological reflection? We answer this question using a hermeneutical research method analyzing 32 texts from the current situation. The data indicate five themes: 1) experiences as sources for spiritual/theological reflection, 2) meaning making as key component for spiritual/theological reflection, 3) growth in spiritual reflection and overlap with theological reflection, 4. some flexible methods; many without explicit method, and 5) spiritual but not religious. Discussion, limitations, and areas for future research are provided.

Increasing Atmospheric Evaporative Demand Across The Tibetan Plateau And Implications For Surface Water Resources, Shiqin Xu, Dennis P. Lettenmaier, Tom R. Mcvicar, Pierre Gentine, Hylke E. Beck, Joshua B. Fisher, Zhongbo Yu, Ningpeng Dong, Akash Koppa, Matthew F. Mccabe

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The Tibetan Plateau, known as the “Asian water tower,” is a hotspot for complex hydroclimatic changes. We reveal that the previously decreasing atmospheric evaporative demand (Eo) trend at the end of the 20th century has reversed over the last two decades. Although both wind stilling and solar dimming have persisted, their effects on Eo rates have been overshadowed by increasing air temperatures and decreasing relative humidity, leading to a net rise in Eo for 1980−2015. Using the empirical “top-down” Budyko approach, we estimate that across seven sub-catchments draining the Tibetan Plateau, a 10% increase in annual-averaged …

Correlates Of Inaccuracy In Reporting Of Energy Intake Among Persons With Multiple Sclerosis, Stephanie L Silveira, Brenda Jeng, Barbara A Gower, Gary R Cutter, Robert W Motl

Faculty, Staff and Student Publications

BACKGROUND/OBJECTIVES: Persons with multiple sclerosis (MS) are interested in diet as a second-line approach for disease management. This study examined potential variables that correlate with inaccuracy of self-reported energy intake (EI) in adults with MS.

METHODS: Twenty-eight participants completed two assessment appointments within a 14-day period that included a standard doubly labeled water (DLW) protocol for estimating total energy expenditure (TEE). The participants reported their EI using the Automated Self-Administered 24 h (ASA24) Dietary Assessment Tool. The primary variables of interest for explaining the discrepancy between TEE and ASA24 EI (i.e., inaccuracy) included cognition (processing speed, visuospatial memory, and verbal …

Hubungan Konsentrasi Pm 2,5 Dengan Keluhan Gangguan Pernapasan Pada Pekerja Uji Mekanis Up Pkb Pulo Gadung, Armando Wijaya Tampubolon, Doni Hikmat Hikmat Ramdhan

National Journal of Occupational Health and Safety

Vehicle emissions including traffic and transportation emissions have become the largest source of particulates in many cities in various countries. Health problems due to particulates from motor vehicles can not only occur around the highway, but can also occur in industries that are in contact with motor vehicles. Under these conditions, researchers wanted to conduct a study at UP PKB Pulo Gadung to see the relationship between PM_2.5 concentrations and complaints of respiratory problems. The study sample totaled 38 people, consisting of mechanical testers and FKM UI community members as a comparison sample. The average result of measurements taken …

Efektivitas Full Body Stretching Dan Edukasi Manual Handling Digital Terhadap Keluhan Musculoskeletal Disorders Pekerja Yantek, Nadia Rosalinda, Anita Sulistyorini, Marji Marji, Supriyadi Supriyadi, Tika Dwi Tama

National Journal of Occupational Health and Safety

Occupational Diseases (PAK) in the form of pain complaints in the skeletal system that cause the work process are called Musculoskeletal Disorders (MSDs). PT. PLN Yantek workers are at risk of experiencing MSDs complaints because the work is done manually and the work posture is less ergonomic. This study aimed to analyze the effect of implementing full-body stretch and digital-based manual handling education and to assess its effectiveness on MSDs. The study used a quasi-experimental method with a one-group pretest-posttest design involving 26 Yantek workers. The intervention was given at 10 meetings, MSDs complaints were measured using the Nordic Body …

The Methodological Problems Of Incorporating Indigenous Philosophy In Collaborative Research, Luthonliu Gangmei, P. Milan Khangamcha

Comparative Philosophy

This paper addresses the methodological challenges inherent in collaborative research endeavours focused on the development of Indigenous philosophy. It argues that these challenges persist due to a lack of recognition of the autonomy and intrinsic philosophical value of ethno-philosophy or Indigenous philosophy. Despite the United Nations acknowledging the significance of indigenous worldviews and their philosophical underpinnings, they are still yet to be fully integrated into the global knowledge domain. The paper highlights the tendency to view indigenous philosophy solely as a cultural asset of indigenous peoples rather than recognizing its broader philosophical relevance. It identifies this as a critical interdisciplinary …

Farm Resilience, Management Practices, And Producer Sentiment: Segmenting Us Farms Using Machine Learning Algorithms, Margaret Lippsmeyer, Michael Langemeier, James R. Mintert, Nathan Thompson

Journal of Applied Farm Economics

Farm managers possess a broad spectrum of capabilities, ranging from tech-savvy, strategically focused managers to those grappling with operational challenges. Our study examines survey data from 403 US commercial producers in order to identify subsets of producers who differ in terms of resilience, management practices, producer sentiment, and other farm characteristics. Utilizing various supervised and unsupervised machine learning techniques, we uncover key farm characteristics that capture the most pronounced variations in survey responses. We then cluster the dataset using these key variables, maximizing separation between clusters and minimizing differences within clusters using Ward’s hierarchical clustering. Fisher’s exact tests are implemented …

Children's Rights Debates, Revisited, Martha Minow

Florida Law Review

A Dunwody distinguished lecture in law that reflects on children's rights.

Virginia Academy Of Sleep Medicine Position Statement On School Start Times In Virginia, Sean Hesselbacher, Mariana Szklo-Coxe, Sachin Relia, Jonathan Gellman, Nicole Mcintyre

Eastern Virginia Medical Journal

The VASM endorses the 2017 AASM position statement that middle and high schools should begin no earlier than 8:30 a.m. The existing and updated scientific literature repeatedly identifies the detrimental impact of early high school start times, and the benefits of delaying start times, on the safety and well-being of students in Virginia. The adverse effects of early school start times on Virginia’s students have been demonstrated, with regards to academic performance, mental health, and driving risks. Data published since the AASM position paper highlight these dangers further. Importantly, recent studies also demonstrate some of the benefits that can come …

The Coming Wave: Technology, Power, And The 21st Century’S Greatest Dilemma, Peter Khooshabeh, Robert Underwood

Joint Force Quarterly

Mustafa Suleyman’s The Coming Wave: Technology, Power, and the 21st Century’s Greatest Dilemma explores the transformative and disruptive impacts of artificial intelligence (AI) and synthetic biology (SynBio), highlighting their potential benefits and existential risks. Suleyman, a co-founder of Google DeepMind, examines the "containment problem"—how to manage the unforeseen consequences of these rapidly advancing technologies. He underscores the democratization of power these technologies enable, their global accessibility, and their potential to create profound societal changes. While Suleyman argues that reinforcing nation-states is essential for containment, the book raises questions about whether international cooperation might be a more viable solution. Suleyman presents …

China’S Use Of Armed Coercion: To Win Without Fighting, Ian Forsyth

Joint Force Quarterly

China’s Use of Armed Coercion, edited by James A. Siebens, examines how China employs military and paramilitary forces to coerce and signal without triggering war, offering valuable insights for policymakers and military strategists. The book analyzes over 200 coercive operations (2000–2021) and highlights China’s ability to frame its actions as defensive while advancing its regional ambitions through intimidation, direct deterrence, and coercion. Case studies, such as sovereignty disputes with the Philippines and India, underscore how China’s military actions are calibrated to avoid outright conflict but maximize psychological and political pressure. The book also explores China’s integration of military and …

Is The Pla Overestimating The Potential Of Artificial Intelligence?, Koichiro Takagi

Joint Force Quarterly

The People’s Liberation Army (PLA) is incorporating artificial intelligence (AI) into its military modernization strategy, or "intelligentization," aiming to develop a world-class military capable of designing future warfare. This article reviews over 370 PLA Daily articles to assess how the PLA envisions AI transforming key areas of warfare, including situational awareness, decisionmaking, unmanned weapons, and cognitive domain operations. While the PLA anticipates significant advantages, it also acknowledges the risks of system malfunctions, biased data, ethical dilemmas, and adversarial manipulation. Despite these limitations, the PLA remains committed to leveraging AI to create new forms of warfare, emphasizing the importance of proactive …

Reassigning Batson: A Modern Approach, Max Angel

Florida Law Review

In Batson v. Kentucky, the Supreme Court of the United States held that using peremptory challenges to strike jurors solely on their race violates the Equal Protection Clause. Following that decision, the Supreme Court extended Batson to gender-based peremptory challenges, holding that state-sponsored group stereotypes rooted in historical prejudice that bars a potential juror from serving on a jury violates that juror’s equal protection right. As it currently stands, there is no federal statute prohibiting peremptory strikes on the basis of sexual orientation or gender identity. And although some courts at the state and federal level have held such …

Breaking Barriers: Investigating Gender Dynamics In Introductory Physics Lab Classes, Bilas Paul, Shantanu Chakraborty, Ganga Sharma

Georgia Journal of Science

The persistent underrepresentation of women and other gender minorities in physical science fields has been an ongoing concern. This study investigates gender dynamics in introductory physics laboratory courses, focusing on whether students of different gender identities exhibit equal inclination and confidence in conducting lab experiments, and whether they face barriers that impact their participation. Conducted across three institutions and involving non-physics STEM students enrolled in algebra-based and calculus-based physics courses, the study found mixed results, with two institutions showing no significant gender-based differences in participation levels during lab activities, while one institution demonstrated significant differences. Chi-square tests revealed no significant …

Centella Asiatica: Recent Cosmeceutical Uses For Treatment Of Skin Diseases, Iman I. Soliman, Nouran Medhat, Huda Saleh, Mai El Halawany

Bulletin of Faculty of Pharmacy Cairo University

Centella asiatica is one of the well-known herbal species used in traditional medicine across Asia such as India, Indonesia, and China. It had been used as a medicinal plant for hundreds of years. Besides its general pharmacological activities such as neuroprotection, anti-cancer and anti-diabetes. It demonstrated effective dermatological actions as being a potent anti-inflammatory, antioxidant, healing and moisturizing properties. The major constituents responsible for these effects were triterpenoids. Triterpenoids included asciaticoside which was reported to induce collagen synthesis. Madecassoside was known for its wound healing properties. It was well known for its efficiency in improving the treatment of hypertrophic wounds. …

Genomic And Proteomic Analyses Of Bacterial Communities Of Ixodes Scapularis Ticks From Broome County, New York, Michel Shamoon-Pour, Emily H. Canessa, John Macher, Amaan Fruitwala, Emma Draper, Benjamin Policriti, Matthew Chin, Matthew Nunez, Paul Puccio, Yuan Fang, Xin-Ru Wang, Yetrib Hathout

Pharmacy Faculty Scholarship

The microbial communities of Ixodes scapularis, the primary vector of Lyme disease in North America, exhibit regional variations that may affect pathogen transmission and vector competence. We analyzed bacterial communities in I. scapularis ticks collected from Broome County, New York, using 16S rRNA gene sequencing (18 ticks) as well as mass spectrometry-based proteomics (36 ticks). According to the 16S rRNA analysis, the endosymbiont Rickettsia buchneri was the most abundant species, with significantly higher (p = 0.0011) abundance in females (54.76%) compared to males (31.15%). We detected Borreliella burgdorferi in 44.44% of ticks and Anaplasma phagocytophilum in two nymphs but in …

The Beacon, January 24, 2025, Beacon Staff

The Beacon, 2024-2025

Unsung Hero: Lori Bonnema; Come enjoy a night of dancing; Zendaya and Holland spark online frenzy; "Wicked" lives up to Broadway original; 2025 fashion throwbacks and throwaways; Heritage Singers present Madrigal Dinners; Comfort to those from far away; Unsung Hero: Lori Bonnema; Diaper drive at local church; Latin dance night; The sad reality of New Year's resolutions; You should try failure; Van Kalsbeek takes down 20-uear-old record; Track and field begins 2025 season; Wrestling charging through 2024-25 season; MLK chapel is moving to many; We all know the BINGO event is not getting old;

The Scarlet - Volume Ciii, No. 7 (January 24, 2025), Scarlet Staff

The Scarlet (Student Newspaper) (2011-present)

The January 24, 2025 edition of The Scarlet (est. 1939), Clark University's student-run newspaper. The Scarlet is intellectually and editorially independent of the University.

The Bison, January, 24, 2025

The Bison Newspapers

No abstract provided.