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Articles 4231 - 4260 of 817980
Full-Text Articles in Entire DC Network
Contextual Hardware Security Using Autonomic Physiological State Signatures, Sudeep Chauhan, Ehsan Nourbakhsh
Contextual Hardware Security Using Autonomic Physiological State Signatures, Sudeep Chauhan, Ehsan Nourbakhsh
Defensive Publications Series
This document describes techniques and architectures for securing a computing device against physically coerced access by utilizing dynamic autonomic physiological state signatures. Processing circuitry of a computing device (e.g., a primary computing device, a wearable sentinel device, or an industrial control terminal) continuously determines a dynamic physiological baseline from sensor data (e.g., heart rate, galvanic skin response, inertial data). A physiological baseline and anomaly engine utilizes a machine learning model, which accounts for contextual states such as active exercise tracking to filter false positives, to detect a distress state corresponding to a non-voluntary autonomic deviation relative to the dynamic physiological …
Differentiation Of Self As A Therapist Effect In Couple Therapy, Nathan D. Knebel
Differentiation Of Self As A Therapist Effect In Couple Therapy, Nathan D. Knebel
Theses and Dissertations
Murray Bowen proposed that a therapist's level of differentiation of self influences therapeutic effectiveness, particularly in clinically distressed relational systems. Although existing literature has demonstrated that therapist effects account for a meaningful portion of variance in couple therapy outcomes, differentiation of self has received limited empirical attention as a therapist-level predictor. The present article proposes a framework for empirically examining Bowen's hypothesis by investigating whether therapist differentiation predicts trajectories of couple relationship quality across treatment. Additionally, the article explores theoretical pathways through which therapists may increase their level of differentiation, assuming Bowen's hypothesis is supported.
Tectonic Influences On The Evolution Of Settlement Decisions In The Near East, Truett Koden W. Marr
Tectonic Influences On The Evolution Of Settlement Decisions In The Near East, Truett Koden W. Marr
Lawrence University Honors Projects
This study asks a fundamental question in archaeology: why do people consistently choose certain places to settle over others? Focusing on the Near East, it investigates how deep-time tectonic features, specifically fault systems, structure long-term settlement decisions by shaping water availability and ecological productivity. To address this, I integrate a large geospatial dataset of 1,023 archaeological sites with 9,075 mapped fault traces across 674 hydrological basins. Using statistics in R, I apply Poisson generalized linear models to test basin-level relationships between site density and fault density and conduct distance-to-fault analyses comparing archaeological sites to randomized controls. These analyses are further …
1 Billion Birds Lost: Mechanisms Of Window Collisions And Possible Mitigation Strategies At Lawrence University, Shoshana Schmit
1 Billion Birds Lost: Mechanisms Of Window Collisions And Possible Mitigation Strategies At Lawrence University, Shoshana Schmit
Lawrence University Honors Projects
Windows are currently the largest killer of birds on the planet, with an estimated 1 billion birds dying from collisions annually. If birds that hit windows do not die on impact, they may either die elsewhere shortly afterwards, resulting in the number of carcasses at collision sites being a conservative estimate of the actual number of fatalities. During the day, proximity to foraging sites and reflectivity play crucial roles in the danger of windows, and during the night, artificial illumination emitting from windows disorients and inhibits navigational cues. To explore this topic on campus, I documented bird collisions at Lawrence …
The Gender Complex: A Survey Of Choral Educators, Anna Milton
The Gender Complex: A Survey Of Choral Educators, Anna Milton
Lawrence University Honors Projects
For this pilot study, I created a survey that was shared with choral directors around Wisconsin. The survey was filled out by 10 choral directors that have experience with single-sex choirs and that teach within Wisconsin. Participants that took the survey are from varying backgrounds, choral education experiences, and identities. This pilot study looks at how previous research lines up and does not line up with teachers in Wisconsin. The survey results explore the common denominators and disagreements found within the answers. This research and resulting paper examines current research, identifies what aligns with the practices of choral educators, who …
With A Great Teacher, 'You Never Know Who Will Change Your Life', Marisa C. Atkinson
With A Great Teacher, 'You Never Know Who Will Change Your Life', Marisa C. Atkinson
University of Mississippi News
OXFORD, Miss. – After 35 years of encouraging students to think, question and discuss, University of Mississippi professor Robert Brown thinks it is time to retire.
Unveiling The Complexity Of Post-Roman Polity Formation In Pannonia Using Ancient Dna, Yijie Tian, István Koncz, Norbert Faragó, Corina Knipper, Ronny Friedrich, Deven N. Vyas, Levente Samu, Olga Spekker, Tamás Szeniczey, Tamás Hajdu, Balázs Gusztáv Mende, Péter Tomka, Ildikó Katalin Pap, Dávid Czigány, Rita Radzeviciute, Luca Traverso, Guido Alberto Gnecchi-Ruscone, Paolo Francalacci, Bernd Schöne, Gábor Tóth, Anna Szécsényi-Nagy, Petrus Le Roux, Kurt W. Alt, Zuzana Hofmanová, Walter Pohl, Johannes Krause, Tivadar Vida, Patrick J. Geary, Krishna R. Vereramah
Unveiling The Complexity Of Post-Roman Polity Formation In Pannonia Using Ancient Dna, Yijie Tian, István Koncz, Norbert Faragó, Corina Knipper, Ronny Friedrich, Deven N. Vyas, Levente Samu, Olga Spekker, Tamás Szeniczey, Tamás Hajdu, Balázs Gusztáv Mende, Péter Tomka, Ildikó Katalin Pap, Dávid Czigány, Rita Radzeviciute, Luca Traverso, Guido Alberto Gnecchi-Ruscone, Paolo Francalacci, Bernd Schöne, Gábor Tóth, Anna Szécsényi-Nagy, Petrus Le Roux, Kurt W. Alt, Zuzana Hofmanová, Walter Pohl, Johannes Krause, Tivadar Vida, Patrick J. Geary, Krishna R. Vereramah
Ecology & Evolution Faculty Publications
The transformation of the Roman world [fourth to ninth centuries common era (CE)], culminating in the Western Roman Empire’s fall, marked a fundamental transition in European history. Key questions persist regarding the regionally specific nature of this transformation. We generated a paleogenomic dataset to reconstruct post-Roman organizations in the Little Hungarian Plain at microregional resolution. Genetic and archaeological analyses of two Roman (n = 68) and five post-Roman (n = 246) sites reveal a rise in Northern European ancestry, reflecting large-scale population movements into this region. Moreover, despite post-Roman sites sharing similar genetic profiles, material culture, and burial …
Metal Oxide Nanoparticle‑Integrated Phema Hydrogels: Morphology, Chemical Properties, And Biological Interaction, Venkateswar Rao, Collin Cox, Brandon Clark, Arushi Rai, Erick S. Vasquez-Guardado, Madhuri Kango-Singh, Soubantika Palchoudhury
Metal Oxide Nanoparticle‑Integrated Phema Hydrogels: Morphology, Chemical Properties, And Biological Interaction, Venkateswar Rao, Collin Cox, Brandon Clark, Arushi Rai, Erick S. Vasquez-Guardado, Madhuri Kango-Singh, Soubantika Palchoudhury
Chemical and Materials Engineering Faculty Publications
Hydrogels offer attractive matrices for incorporating inorganic metal oxide nanoparticles (NPs) to generate multifunctional hybrid materials, but challenges remain in scalable synthesis and correlating their properties to bio-interaction. Therefore, we report the synthesis and characterization of poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels, and pHEMA hydrogels encapsulating iron oxide or zinc oxide NPs, using a modified free-radical polymerization. Dose-dependent survivorship studies on Drosophila melanogaster revealed that both NP-embedded hydrogels are tolerated over a wide dose range (e.g., 50–200 mg), although ZnO NP-gels exhibit lower survivorship at some concentrations due to their inherent composition and a wider size distribution of iron oxide NPs.
From Combustion Emissions To Neurotoxicity: Brain Health Risks Of Military Burn Pits Exposure, Katherine M. Eggers, Zoe A. Keller, Paul Barach, Julie M. Tomáška, Joshua P. Nixon, Janeen H. Trembley, Tammy A. Butterick
From Combustion Emissions To Neurotoxicity: Brain Health Risks Of Military Burn Pits Exposure, Katherine M. Eggers, Zoe A. Keller, Paul Barach, Julie M. Tomáška, Joshua P. Nixon, Janeen H. Trembley, Tammy A. Butterick
College of Population Health Faculty Papers
Military burn pits used during post-9/11 U.S. military deployments functioned as uncontrolled combustion systems and were widely utilized to dispose of large volumes of outdoor waste by burning. Burn pits involved heterogeneous waste materials burned under variable temperature and oxygen conditions. These combustion environments generated complex, toxic, multipollutant airborne emission mixtures that included particulate matter (PM2.5), polycyclic aromatic hydrocarbons (PAHs), and volatile organic compounds (VOCs). This narrative review synthesizes epidemiologic, experimental, and mechanistic evidence linking burn pit emissions to disruption of the lung–brain axis and adverse neurological outcomes. We specifically aim to address a critical gap in understanding how combustion-derived …
Structure-Based Discovery Of Malate Dehydrogenase Inhibitors With Efficacy Against C. Parvum Oocysts, Ankita Bharatbhai Kheni
Structure-Based Discovery Of Malate Dehydrogenase Inhibitors With Efficacy Against C. Parvum Oocysts, Ankita Bharatbhai Kheni
Biochemistry and Molecular Biology
Cryptosporidium parvum, the etiological agent of Cryptosporidiosis (diarrheal illness) represents a significant global health burden, particularly affecting immunodeficient and pediatric populations. Since the parasite has a highly reduced mitochondrion and relies on glycolysis, enzymes such as C. parvum malate dehydrogenase (CpMDH), which are believed to be indispensable for parasite viability due to their pivotal roles in NAD⁺ regeneration and redox balance, remain largely unexplored as therapeutic targets. The present study employed a multifaceted experimental and computational strategy to evaluate the inhibitory activity of two lead-like and drug-like small molecules, referred to as compound 1.8 and compound 1.5, against the cofactor …
Instagram Influencers And Egyptian Women: Links To Self- Perception And Behavior, Fatma El Sayad
Instagram Influencers And Egyptian Women: Links To Self- Perception And Behavior, Fatma El Sayad
Theses and Dissertations
The rapid rise of Instagram influencers has transformed the ways young women engage with media, shaping perceptions of appearance, lifestyle, success, and everyday behavior. This study examines how frequent exposure to Instagram influencers affects self-esteem, internalization of beauty and lifestyle ideals, perceived realism of influencer content, and behavioral and consumption habits among young Egyptian females. The study explores participants’ lived experiences, interpretations, and coping strategies in relation to influencer culture. Perceived influencer credibility emerged as a key factor for females to follow them, influencers viewed as relatable, specialized, and transparent were more likely to inspire adaptive behaviors, whereas those promoting …
Fathers’ Footprints: The Role Of The Father-Son Relationship In Shaping Men’S Experience And Expression Of Anger In Egypt, Lydia E. Wassef
Fathers’ Footprints: The Role Of The Father-Son Relationship In Shaping Men’S Experience And Expression Of Anger In Egypt, Lydia E. Wassef
Theses and Dissertations
Abstract
In many Egyptian families, the father holds a central position as an authority figure, a protector, and a provider, yet often remains emotionally reserved and relationally distant. The emotional legacy of paternal acceptance or rejection extends into adulthood, shaping patterns of emotional regulation. Particularly, the father-son relationship plays a fundamental role in shaping men’s experiences and expressions of anger. Within cultural contexts discouraging vulnerability and associating masculinity with strength and emotional restraint, anger may become one of the few socially acceptable modes of emotional expression for men. This study positions these dynamics within the cultural context of fatherhood in …
Determinants Of Corporal Punishment And Severe Physical Punishment In Egypt: A Mixed-Methods Analysis For Child Protection Policy, Marwa Moustafa Nassef
Determinants Of Corporal Punishment And Severe Physical Punishment In Egypt: A Mixed-Methods Analysis For Child Protection Policy, Marwa Moustafa Nassef
Theses and Dissertations
Corporal punishment (CP) and severe physical punishment (SPP) remain a major public health, child rights, and child protection policy concern. In Egypt, despite legislative reforms, survey-weighted analysis of the 2021 Egypt Family Health Survey (EFHS) 2021 (CAPMAS, 2022) reveals prevalence rates of 60.5% for CP and 27.4% for SPP among children aged 1–14 (author’s calculations using EFHS-2021, n=7623), yet evidence distinguishing the determinants of routine corporal punishment from escalation to severe physical punishment remains limited in low- and middle-income contexts. Guided by Bronfenbrenner’s ecological framework, this mixed-methods study identifies key drivers of CP and its escalation to SPP among Egyptian …
Mapping The Neuroexposome: Integrative Analysis Of Dementia Risk Factors Through Multi-Omics And Environmental Profiling In The Egyptian Population., Mai Ahmed Saadzaghloul Othman
Mapping The Neuroexposome: Integrative Analysis Of Dementia Risk Factors Through Multi-Omics And Environmental Profiling In The Egyptian Population., Mai Ahmed Saadzaghloul Othman
Theses and Dissertations
Background: Dementia represents one of the most pressing public health challenges of the twenty-first century, with the global burden projected to reach 153 million cases by 2050. Egypt, as the most populous Arab nation, faces a corresponding rise in age-related diseases, yet comprehensive data from low- and middle-income countries remain severely limited. The neuroexposome framework, integrating genetic susceptibility, environmental exposures, and metabolic alterations, offers a powerful strategy to characterize the complex interplay between internal and external risk factors for Alzheimer's disease (AD) and Alzheimer's disease Related Dementias (ADRD).
Objectives: This thesis aimed to: (1) examine the distribution of APOE alleles …
Seeing A Future Where I Exist As Myself: An Exploration Of Suicidality As A Response To Sociopolitical Oppression In Transgender And Gender Expansive Populations, Alexander Ray Sequoia
Seeing A Future Where I Exist As Myself: An Exploration Of Suicidality As A Response To Sociopolitical Oppression In Transgender And Gender Expansive Populations, Alexander Ray Sequoia
University Honors Theses
Suicide is often considered a mental health issue alone. For Transgender and gender non-conforming (TGNC) people, suicide can be a response to erasure of self and living under oppression conditions. The sociopolitical climate in the United States (U.S.), has become more hostile for TGNC people, along with legislative action that criminalizes their existence. This project explores the intersections of identity and nuances of suicide and death. The present study consists of 14 semi-structured interviews. This study examined the intersections of gender and culture on suicide responses, highlighting the importance of culturally relevant and community-led support for Transgender and gender expansive …
The Gut Microbiome, The Gut-Brain Axis, And College Student Well-Being, Idi Mckay
The Gut Microbiome, The Gut-Brain Axis, And College Student Well-Being, Idi Mckay
University Honors Theses
This literature review examines how diet, stress, environmental exposure, and food accessibility may influence college students' mental health and academic performance through the gut microbiome and the Gut-Brain Axis (GBA). Current microbiome research often focuses on early childhood development, clinical disease populations, or older adults, while overlooking college-age students who experience significant social, environmental, and biological transitions. College students frequently face food insecurity, irregular eating patterns, chronic stress, inconsistent sleep schedules, and reduced access to nutrient-dense foods, all of which may influence microbial diversity and overall gut health.
This thesis explores how modern campus environments and lifestyle factors may contribute …
Statewide Multi-Year Wastewater Sequencing Reveals Dual Origins Of Hiv-1 Signal, Justin R Clark, Dylan Chirman, Harihara Prakash, Austen Terwilliger, Marlene Mcneese, Matt Ross, Mike Tisza, Sara J Javornik Cregeen, Loren Hopkins, Jennifer Deegan, Catherine L Troisi, Eric Boerwinkle, Kristina Mena, Fuqing Wu, Jason T Kimata, Marc Johnson, Devon Gregory, Faith E Fletcher, Thomas P Giordano, Anthony W Maresso
Statewide Multi-Year Wastewater Sequencing Reveals Dual Origins Of Hiv-1 Signal, Justin R Clark, Dylan Chirman, Harihara Prakash, Austen Terwilliger, Marlene Mcneese, Matt Ross, Mike Tisza, Sara J Javornik Cregeen, Loren Hopkins, Jennifer Deegan, Catherine L Troisi, Eric Boerwinkle, Kristina Mena, Fuqing Wu, Jason T Kimata, Marc Johnson, Devon Gregory, Faith E Fletcher, Thomas P Giordano, Anthony W Maresso
Faculty, Staff and Students Publications
Human immunodeficiency virus 1 (HIV-1) is a retrovirus which has infected 90 million people and resulted in over 40 million deaths. Despite advances in diagnostics, treatment, and prophylaxis, HIV-1 continues to spread due to undiagnosed and untreated infections. Traditional monitoring methods are ineffective when access to testing is limited or people do not seek care, particularly given the long period between infection and symptom onset, allowing undetected transmission to continue. Here, we use a hybrid-capture sequencing approach to track HIV-1 signal in municipal wastewater in 15 different cities over nearly 3 years. We obtain near-complete genomic coverage of HIV-1, enabling …
Investigating Femoral Growth Stunting And Cortical Bone Deposition: A Bioarchaeological Case Study From 17th Century Transylvania, S. M. August Stone
Investigating Femoral Growth Stunting And Cortical Bone Deposition: A Bioarchaeological Case Study From 17th Century Transylvania, S. M. August Stone
Electronic Theses and Dissertations
This study utilizes the World Health Organization’s growth stunting identification standards to investigate the possibility of growth stunting in a collection of subadult remains from Telekfalva, Transylvania, Romania. Length-for-age is estimated using femur length and dental development stage (Shaefer et al., 2009) and compared to the Maresh Standard Growth Data (Maresh, 1943, 1955, 1970). Growth stunting is identified in individuals who fall less than -two standard deviations from the expected femur length-for-age. Additionally, this research investigates a pattern of abnormal, multilayered cortical bone deposition seen primarily in individuals with growth stunting. The correlation between abnormal cortical bone deposition and growth …
Colostrum Management For Dairy Calves: Technical Guidelines For Consultant Evaluation And Implementation, Drew Swartz, Jacob Hadfield, Kalen Taylor, Maggi Mathews
Colostrum Management For Dairy Calves: Technical Guidelines For Consultant Evaluation And Implementation, Drew Swartz, Jacob Hadfield, Kalen Taylor, Maggi Mathews
All Current Publications
This fact sheet provides a technical overview of colostrum management in dairy calves, including evaluation methods and evidence-based recommendations for consultants, educators, and students.
Fatherhood In Egypt: Identity Formation And Role Theory Perspectives, Mahmoud Nasr Gawdat
Fatherhood In Egypt: Identity Formation And Role Theory Perspectives, Mahmoud Nasr Gawdat
Theses and Dissertations
Fatherhood is a central yet under-researched dimension of family life in Egypt, particularly from a psychological and identity-based perspective. This study explores how Egyptian fathers construct and experience fatherhood through the lenses of identity theory and role theory. Using a qualitative research design, seven focus groups were conducted with 43 Egyptian fathers to examine the meanings they attribute to fatherhood, their perceived roles, challenges, support systems, and personal transformations. Thematic analysis revealed six interconnected themes: (1) describing the father’s role, (2) learning the father role, (3) social and cultural influences on the father role, (4) meaning of being a father, …
Enhancing The Performance Of Brain-Computer Interfaces Via A Spatially-Aware Framework, Ahmed Ayman Eloraby
Enhancing The Performance Of Brain-Computer Interfaces Via A Spatially-Aware Framework, Ahmed Ayman Eloraby
Theses and Dissertations
Electroencephalography (EEG)-based brain–computer interfaces (BCIs) provide a non-invasive pathway for communication, with the P300 speller being one of the most established paradigms. Despite its practicality, EEG signals present inherent challenges, including low signal-to-noise ratio, high dimensionality, and limited spatial resolution. These characteristics complicate the extraction of discriminative spatial patterns, which are critical for accurate P300 detection and character-level decoding.
This thesis addresses these challenges through the development of AttenPCA-Net, a deep learning framework that integrates spatially-aware processing with dimensionality reduction. Principal Component Analysis (PCA) is employed to reduce redundancy and noise while preserving the most informative components of the EEG …
An Integrated Sensor-Fusion Framework For Performance-Based Compensation In Construction, Aly Ayman El-Ashry
An Integrated Sensor-Fusion Framework For Performance-Based Compensation In Construction, Aly Ayman El-Ashry
Theses and Dissertations
Construction productivity has historically stagnated due to a reliance on subjective labor monitoring and “lagging” performance indicators. This research proposes a novel compensation model with the use of Total Energy Management System (TEMS) to translate labor effort and efficiency into payment incentives with the integration of Internet of Things (IoT) wearables and Statistical Process Control (SPC) charts.
This research addresses the systemic problem of declining construction productivity caused by industry’s inability to objectively quantify human effort. While traditional models rely on post-facto production tallies, a significant research gap exists in real-time physiological labor monitoring. To bridge this, the proposed TEMS …
The Paradox Of Palestinian Exile: Unrwa, Structural Limbo, And The Manufactured Crisis Of The Right To Return, Laila Ibrahim Hassan Elkassas
The Paradox Of Palestinian Exile: Unrwa, Structural Limbo, And The Manufactured Crisis Of The Right To Return, Laila Ibrahim Hassan Elkassas
Theses and Dissertations
This thesis argues that the temporariness of Palestinian exile has been turned into a manufactured limbo that is sustained by international law, humanitarian governance and host- country regimes. It uses General Assembly Resolution 194 and the broader human rights regime to show how the right to return is constantly reaffirmed but structurally postponed, resulting in a gap between legal promise and political reality. Drawing on Edward Said’s notion of exile as an unhealable rift, Pierre Bourdieu’s concept of habitus and Didier Fassin’s thinking on humanitarian reason, the thesis constructs a multi-scalar framework that conceptualizes limbo as existential experience, embodied practice …
Creating Sustainable School And Home Gardens: Managing Rainwater, Lawrence Krissek, Kathy Cabe Trundle
Creating Sustainable School And Home Gardens: Managing Rainwater, Lawrence Krissek, Kathy Cabe Trundle
All Current Publications
Rainscaping can help solve drainage problems, reduce erosion, improve water quality, and conserve soil by effectively managing rainwater movement across the landscape. It can also provide environments with increased biodiversity while reducing the need for supplemental watering. The details of rainscaping your garden are very site-specific, affected by the amount of space and money available, your garden’s physical and weather/climate characteristics, and your garden goals. This resource sheet addresses the use of natural methods to ensure efficient rainwater management.
Basic Bronchoscopy Competence Achieved During A One-Day Workshop For A Multidisciplinary Critical Care Team: A Simulation-Based Study, Jayakrishnan B, Saif Musabah Al-Mubaihsi, Hasan Al-Sayegh, Ahmed Zaher Al-Abri, Issa Saif Alqarshoubi, Jehan Al-Abri, Sami M Bennji
Basic Bronchoscopy Competence Achieved During A One-Day Workshop For A Multidisciplinary Critical Care Team: A Simulation-Based Study, Jayakrishnan B, Saif Musabah Al-Mubaihsi, Hasan Al-Sayegh, Ahmed Zaher Al-Abri, Issa Saif Alqarshoubi, Jehan Al-Abri, Sami M Bennji
Sultan Qaboos University Medical Journal
Objectives: Fibreoptic bronchoscopy has become a key procedure in critical care, transitioning from pulmonologists to intensivists. This study aimed to evaluate the effectiveness of a one-day simulation-based training programme in acquiring basic bronchoscopy skills.
Methods: A one-day workshop was conducted at Sultan Qaboos Comprehensive Cancer Care and Research Centre, University Medical City, Muscat, Oman, in October 2024 with didactic lectures, small group skill stations, virtual bronchoscopy simulations and hands-on training using manikins and a novel, cost-effective, 3D-printed airway model. The pre-course knowledge of the attendees and their gain in skill were assessed with a 50-question survey tool.
Results …
Patterns Of Brain-Wide Associations Reflect Socioeconomics, Scott Marek, Meghan Rose Donohue, Nicole R Karcher, Caroline P Hoyniak, Roselyne J Chauvin, Ashley C Meyer, John Miller, Andrew N Van, Anxu Wang, Noah J Baden, Vahdeta Suljic, Kristen M Scheidter, Julia Monk, Forrest I Whiting, Nadeshka J Ramirez-Perez, Samuel R Krimmel, Athanasia Metoki, Rebecca F Schwarzlose, Steven E Petersen, Joan Luby, Benjamin P Kay, Evan M Gordon, Timothy O Laumann, Deanna M Barch, Nico U F Dosenbach, Et Al.
Patterns Of Brain-Wide Associations Reflect Socioeconomics, Scott Marek, Meghan Rose Donohue, Nicole R Karcher, Caroline P Hoyniak, Roselyne J Chauvin, Ashley C Meyer, John Miller, Andrew N Van, Anxu Wang, Noah J Baden, Vahdeta Suljic, Kristen M Scheidter, Julia Monk, Forrest I Whiting, Nadeshka J Ramirez-Perez, Samuel R Krimmel, Athanasia Metoki, Rebecca F Schwarzlose, Steven E Petersen, Joan Luby, Benjamin P Kay, Evan M Gordon, Timothy O Laumann, Deanna M Barch, Nico U F Dosenbach, Et Al.
2020-Current year OA Pubs
Previous brain-wide association studies (BWAS) have linked specific environmental and behavioral variables to brain variability. In this work, we mapped 649 variables to children's brains and compared the resultant BWAS maps with each other and with neurobiological reference patterns. Socioeconomic status (SES) showed the strongest brain-wide associations. The SES associations were strongest in motor and sensory but not cognitive regions, a pattern shared across many BWAS maps, including intelligence quotient (IQ). A single, common BWAS brain pattern existed across variables that was most reflective of a child's socioeconomics. Adjusting for SES weakened brain-IQ associations, eliminating the BWAS motor and sensory …
Bap1 Loss Links Myc Activation, Stress Response Vulnerability, And Disease Progression In Kidney Cancer, Ilya Strunilin
Bap1 Loss Links Myc Activation, Stress Response Vulnerability, And Disease Progression In Kidney Cancer, Ilya Strunilin
Arts & Sciences Graduate Student Theses and Dissertations
BAP1, a chromatin modifier, is a frequently mutated tumor suppressor in clear cell renal cell carcinoma (ccRCC). Mutations in BAP1 are associated with a more aggressive and lethal disease. However, the downstream mediators of BAP1 loss in ccRCC oncogenesis are not well understood. To better understand mechanisms of BAP1-mediated tumor suppression, I have extensively characterized the very early transcriptional mediators of BAP1 loss in a postnatal kidney-specific genetic knockout model. Because VHL loss is the initiating event in ccRCC, we modeled Bap1 loss in a Vhl-deficient background. I have found that Vhl/Bap1 double-knockout cells of PT segment S2 strongly activate …
Defining Replication-Driven Vulnerabilities In High Grade Serous Ovarian Cancers, Natasha Maya Ramakrishnan
Defining Replication-Driven Vulnerabilities In High Grade Serous Ovarian Cancers, Natasha Maya Ramakrishnan
Arts & Sciences Graduate Student Theses and Dissertations
High grade serous ovarian carcinoma (HGSOC) is an aggressive, highly lethal subtype of ovarian cancer. These cancers are typically diagnosed in later stages and are associated with poor patient prognosis. Additionally, HGSOC is characterized by numerous markers of genomic instability and defects in DNA repair pathways, vulnerabilities which have been exploited by the advancement of chemotherapy. Despite these clinical advancements, HGSOC remains a significant therapeutic challenge due to emergence of chemoresistance and limited targeted treatment options. Taken together, these factors highlight an ongoing need to study the development of HGSOC and its progression to identify more effective treatment opportunities. We …
Effect Of Temperature On The Defensive And Predatory Behavior Of The Scorpion Hadrurus Obscurus (Scorpiones: Hadruridae), Zia Nisani, Megan Bennett, Audrey Enriquez, Mel Iniquez, Emilia Martinez Rios, Brooklyn Stone
Effect Of Temperature On The Defensive And Predatory Behavior Of The Scorpion Hadrurus Obscurus (Scorpiones: Hadruridae), Zia Nisani, Megan Bennett, Audrey Enriquez, Mel Iniquez, Emilia Martinez Rios, Brooklyn Stone
Euscorpius
Scorpions employ their stinging mechanism both for defense and predation, and being ectothermic, temperature influences their physiology and behavior. As such, we hypothesized that temperature both affects defensive stinging and prey-capture behavior in scorpions. We tested the effects of body temperature on these behaviors in the desert hairy scorpion, Hadrurus obscurus Williams, 1970. In the first experiment, scorpions were placed in temperature-controlled chambers with either high (26-28°C) or low (21- 22°C) temperatures and probed to elicit a defensive sting. We recorded the reaction time and the number of probes needed to elicit a sting. In the second experiment, we observed …
Level Of Nitrogen Fertilizer In Annual Winter Pasture (Oats-Ryegrass) And Summer Pasture (Millet): Effects On Milk Production, C J. Olivo, I L. Barreto, D A. Stiles
Level Of Nitrogen Fertilizer In Annual Winter Pasture (Oats-Ryegrass) And Summer Pasture (Millet): Effects On Milk Production, C J. Olivo, I L. Barreto, D A. Stiles
IGC Proceedings (1977-2023)
Two experiments were conducted with lactating Holstein cows to study the effects of different levels of nitrogen fertilizer (urea) on annual pasture: experiment 1, oats (Avena byzantina K. Koch) and ryegrass (Lolium multiflorum Lam.); experiment 2, millet (Pennisetum americanum (L.] Leche). Base fertilizer (8-28-18) was applied, and at the five-leaf stage three levels of nitrogen (N) (75, 150, and 225 kg/ha) were applied. The millet pasture followed the oat + ryegrass pasture, with the N treatments being maintained in the same areas. Two ha were planted for each treatment (total, 6 ha). In experiment 1, twelve lactating cows were randomly …