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Spartan Daily, February 13, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 164, Issue 10

Successful Posthospitalisation Oncology Workflow Implementing Lace+ Score To Stratify And Reduce Readmissions Within A Safety-Net Hospital, Cindy M Pabon, Janine Wong, Marcela Perez, Jessica Jimenez-Abarca, Lianchun Xiao, Lymesia Jackson, Anne Park, Anjali Lankford, Vinita Akula, Saumil Datar, Taylor Hopper, Yaser Alkhatib, Terri Earles, Tejal Patel

Faculty, Staff and Student Publications

Background: Patients with advanced cancers visit the emergency room and get hospitalised frequently, with potentially half of these visits being avoidable. Our institution provides comprehensive, low-cost cancer treatment to a safety-net population in Texas. We performed a retrospective review of hospital readmission patterns amongst our oncology patients and developed a posthospitalisation workflow to reduce readmissions.

Method: Following discharge, oncology patients were risk stratified based on their Length of stay, Acuity of admission, Charlson comorbidity index score and Emergency department visits+index in the past 6 months. The higher the score, the quicker the outpatient oncology follow-up. In addition to addressing acute …

Structure-Activity Relationship Studies Of Dna Methyltransferase 1 Monovalent Degraders, Chao Qian, Youngeun Lee, Yulin Han, Yue Zhong, Jujun Zhou, Joel Hrit, Ling Xie, Qin Chen, H Ümit Kaniskan, Xian Chen, Scott Rothbart, Xiaodong Cheng, Yan Xiong, Jian Jin

Faculty, Staff and Student Publications

DNA methyltransferase 1 (DNMT1), which catalyzes maintenance methylation of hemimethylated DNA during DNA replication, is overexpressed in cancer. Recently, the first-in-class DNMT1-selective noncovalent small-molecule inhibitors, GSK3484862 and GSK3685032, were discovered. These inhibitors were also reported to degrade DNMT1. However, structure–activity relationship (SAR) studies of these monovalent DNMT1 degraders are lacking. Here, we report our SAR studies of this scaffold on degrading DNMT1, which led to the discovery of multiple lead degraders, including compound 4 (MS9024). Compound 4 potently and selectively degraded DNMT1 in multiple cancer cell lines in a concentration-, time-, and proteasome-dependent manner without altering DNMT1 transcription. Further mechanism-of-action …

Inhibition Of Histone Methyltransferase Ezh2 For Immune Interception Of Colorectal Cancer In Lynch Syndrome, Charles M Bowen, Fahriye Duzagac, Abel Martel-Martel, Laura Reyes-Uribe, Mahira Zaheer, Jacklyn Thompson, Nan Deng, Ria Sinha, Soham Mazumdar, Melissa W Taggart, Abhinav K Jain, Elena Tosti, Winfried Edelmann, Krishna M Sinha, Eduardo Vilar

Faculty, Staff and Student Publications

Colorectal precancers in Lynch syndrome (LS) exhibit a distinct immune profile, presenting unique opportunities for developing immune-interception strategies to prevent carcinogenesis. Epigenetic modulation by EZH2 of immune-related genes is implicated in the carcinogenesis of different cancer types, including colorectal cancer. This study utilizes a mouse model of LS and ex vivo colonic organoids to assess the effects of the EZH2 inhibitor GSK503 on immune regulatory pathways, tumorigenesis, and epigenetic reprogramming. Our findings revealed that GSK503 significantly increased CD4+ and CD8+ T cells in both splenocytes and colonic mucosa of treated mice compared with controls. Additionally, a preventive dose of GSK503 …

Kenyon Collegian - February 13, 2025

The Kenyon Collegian

No abstract provided.

Prediction Of Cognitive Conversion Within The Alzheimer’S Disease Continuum Using Deep Learning, Siyu Yang, Xintong Zhang, Xinyu Du, Peng Yan, Jing Zhang, Wei Wang, Jing Wang, Lei Zhang, Huaiqing Sun, Yin Liu, Xinran Xu, Yaxuan Di, Jin Zhong, Caiyun Wu, Jan D Reinhardt, Yu Zheng, Ting Wu

Faculty, Staff and Students Publications

Background: Early diagnosis and accurate prognosis of cognitive decline in Alzheimer's disease (AD) is important to timely assignment to optimal treatment modes. We aimed to develop a deep learning model to predict cognitive conversion to guide re-assignment decisions to more intensive therapies where needed.

Methods: Longitudinal data including five variable sets, i.e. demographics, medical history, neuropsychological outcomes, laboratory and neuroimaging results, from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort were analyzed. We first developed a deep learning model to predicted cognitive conversion using all five variable sets. We then gradually removed variable sets to obtained parsimonious models for four different …

Beyond Lectures: Leveraging Competition, Peer Discussion And Real-World Scenarios In A Digital Card Game To Enhance Learning Of Microbiology And Immunology Concepts, Michael Dillon, James Edwards, Alexandra Hughes, Holly Stephenson

Peninsula Medical School

Teaching the complex interactions between hosts and pathogens is a fundamental yet educationally challenging aspect of life science and healthcare education. The intricate mechanisms of the immune system can pose significant barriers to students’ understanding of infectious disease diagnosis and treatment. To address this, we used a web-based digital whiteboard platform to design a card-based competitive game called Micro-Immune Battles, aimed at more actively engaging students with microbiology and immunology to better develop their knowledge and underlying concepts. The game facilitates learning through a series of infectious disease scenarios, providing student teams with ‘immune system response cards’ that represent various …

Navigating Epstein-Barr Virus (Ebv) And Post-Transplant Lymphoproliferative Disorder (Ptld) In Pediatric Liver Transplantation: Current Knowledge And Strategies For Treatment And Surveillance, Erin Y Chen, Natasha Dilwali, Krupa R Mysore, Sara Hassan, Sara Kathryn Smith, Wikrom Karnsakul

Faculty, Staff and Students Publications

Epstein-Barr virus (EBV) is strongly associated with the development of post-transplant lymphoproliferative disorder (PTLD) in pediatric liver transplant recipients. PTLD is one of the most common malignancies following liver transplantation and is associated with significant morbidity and mortality. Factors such as EBV-serostatus mismatch and prolonged or high levels of immunosuppression impact a patient's risk of developing PTLD. While pre-transplant EBV serological screening and post-transplant monitoring of EBV-DNA levels are strongly recommended, universal guidelines for its prevention and management are lacking. Due to a lack of robust prospective studies, current clinical practices vary widely. The treatment of PTLD typically involves reducing …

Plasma Micrornas To Select Optimal Patients For Antibody Production From Anti-Addiction Vaccines, Thomas R Kosten, Amrit Koirala, David A Nielsen, Coreen B Domingo, Ynhi T Thomas, Preethi H Gunaratne, Cristian Coarfa

Faculty, Staff and Students Publications

Background: Cocaine and illicit amphetamines (disguised as “Adderall”) are being laced with fentanyl and producing accidental and intentional fatal overdoses. Vaccines can prevent these overdoses, but 33% of humans generate insufficient anti-drug antibody (AB) levels. Plasma microRNAs (miRs) can be used to predict non-responders. We have plasma stored from 152 cocaine vaccine trial participants following three vaccinations over 9 weeks and examined miRs as potential response biomarkers. Methods: We compared 2517 miRs before anti-cocaine vaccination in participants with the highest (n = 25) to the lowest (n = 23) antibody levels. False Discovery Rates (FDRs) were applied to identify differentially …

Effective Antioxidant Production Through Submerged Fermentation Of Edible Mushrooms, Sukanya Jiamworanunkul

The Thai Journal of Pharmaceutical Sciences

Objective: The present work was designed to apply the submerged fermentation of five edible mushrooms including Schizophyllum commune, Lentinus polychrous, Lentinula edodes, Ganoderma lucidum, and Lentinus squarrosulus for antioxidant production. Methods: The antioxidant activity and total phenolic content (TPC) of 30 different broth and mycelium extracts acquired from the submerged mushroom fermentation in three liquid media, malt extract broth (MEB), potato dextrose broth (PDB), and yeast extract sucrose broth, were determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay and Folin-Ciocalteu colorimetric method, respectively. Results: All the extracts were found to possess antioxidant properties and contain phenolic compounds. The percentage of DPPH …

Morphological And Anatomical Diagnostic Features Of Aristolochia Clematitis L. Herb., Irina O. Suina, Olga V. Yakovleva, Inna I. Terninko, Maria N. Povydysh, Miroslava V. Ogloblina

The Thai Journal of Pharmaceutical Sciences

Diagnostic macro- and microscopic features of Aristolochia clematitis L. herb were established as an obligatory element for the standardization of medicinal plant raw materials. They are as follows: Stems are cylindrical, unbranched, leaves are simple, petiolar, leaf blade is entire, and broadly ovate to rounded-triangular. Leaf base is deeply reniform, tip pointy concave. Leaf epidermis cells tortuous, stomata of anomocytic type, and glands with essential oil are present. The stem and petiole have fascicles of open collateral type.

Design And Molecular Docking Of Novel 5-O-Benzoylpinostrobin Derivatives As Anti-Breast Cancer, Mohammad Rizki Fadhil Pratama, Hadi Poerwono, Siswandono Siswandono

The Thai Journal of Pharmaceutical Sciences

Objectives: This study aims to design the 5-O-Benzoylpinostrobin derivative with the most potent anti-breast cancer activity along with the most dominant type of receptor for the compound. Methods: Molecular docking was performed using AutoDock 4.2.6 on four types of breast cancer receptors consisting of estrogen receptors α and β, progesterone receptors, and human epidermal growth factor receptor 2 (HER2), both in the form of binding to agonist and antagonist ligands. The parameters used were the free energy of binding (ΔG) and the dissociation constant (Ki) as an affinity marker and similarity of amino acid residues as interactions similarity indicator. Results: …

The Evaluation On Anti-Platelet And Antithrombosis Activities Of Cinnamomum Sintoc Bark Extract, Nanang Fakhrudin, Tri Wiyono, Arbie Ristanto Putra, Sitarina Widyarini, Arief Nurrochmad

The Thai Journal of Pharmaceutical Sciences

Introduction: One of the factors contributing to cardiovascular diseases is platelet aggregation. Although several antiplatelet agents have been introduced into clinical practices, discovery of antiplatelet agents is still challenging. Plants from the genus of Cinnamomum were previously reported to have antiplatelet activity. This study aimed to determine the activity of Cinnamomum sintoc (CS) bark extract inhibiting platelet aggregation and thrombosis. Materials and Methods: Antiplatelet activity of CS bark methanolic extract (CS methanolic extract [CSME]) (5–300 μg/mL) was determined by measuring the ability of the extract to inhibit platelet aggregation induced by epinephrine. Meanwhile, the antithrombosis activity was determined by calculating …

Investigation Of Lipophilic And Hydrophilic Leaf Extracts Of Portulaca Oleracea On Gestation In Albino Rats (Rattus Norvegicus), Victoria Chinenye Obinna, Hope Delesi Kagbo, Gabriel Ogaba Agu

The Thai Journal of Pharmaceutical Sciences

Background: Portulaca oleracea Linn. is one of the indigenous plants currently gaining ground and recognition globally as both vegetable and medicinal herb. The scarcity of literature on the safety of P. oleracea uses in pregnancy prompted this research. Objective: This study investigated the effect of the lipophilic and hydrophilic leaf extracts of P. oleracea on gestation/fetal indices. Methods: The extracts were obtained using two extracting solvents – chloroform and 80% aqueous methanol in succession. Thirty-five successfully mated female rats were divided into seven groups. Group 1 (control) received 0.5 ml 20% Tween 80 (vehicle), Groups 2, 3, and 4 received …

Protective Effect Of Phikud Navakot Extract Against Hydrogen Peroxide-Induced Oxidative Stress In Hepg2 Cells, Abhiruj Chiangsom, Rawiwan Maniratanachote, Duangduen Meksuriyen, Rataya Luechapudiporn, Kornphimol Kulthong, Sasitorn Aueviriyavit, Shingo Oda, Tsuyoshi Yokoi, Somsong Lawanprasert

The Thai Journal of Pharmaceutical Sciences

Objective: The purpose of the study is to evaluate the hepatoprotective effects of Phikud Navakot (PN) extract against hydrogen peroxide (H2O2)-induced oxidative stress in HepG2 cells. Materials and Methods: The cells were treated with concentrations of PN up to 1 mg/ml before incubation with H2O2. Cell viability and reactive oxygen species (ROS) generation were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and 2′,7′-dichlorofluorescein diacetate assays, respectively. Oxidative defense mechanisms were investigated by measuring glutathione (GSH) levels and activities of antioxidant enzymes. Expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) proteins was investigated by Western blot analyses. Results: The …

Full Issue

Intuition: The BYU Undergraduate Journal of Psychology

No abstract provided.

Parental Strategies For Modifying Behavior: The Positives Of Positive Reinforcement, Benjamin D. Rasmussen

Intuition: The BYU Undergraduate Journal of Psychology

This research investigates the effectiveness of positive reinforcement as a central parenting strategy for modifying children’s behavior, grounded in B.F. Skinner’s operant conditioning theory. Using factor analysis, two key factors emerged: the impact of positive reinforcement on behavior change and its influence on parent-child dynamics. Positive reinforcement, which involves rewarding desirable behaviors with positive stimuli, has been found to promote the repetition of those behaviors and yield beneficial long-term outcomes. The evidence indicates that this approach not only strengthens desirable behaviors but also enhances the quality of relationships between parents and children, and teachers and students. Although some argue that …

A Literary Review On The Effects Of Music Therapy On Depressed Adolescents: Brain Function, Individual Therapy, And Group Psychotherapy, Bella Mccain

Intuition: The BYU Undergraduate Journal of Psychology

This paper presents a literature review examining the impact of music therapy on adolescents with major depressive disorder (MDD). Music therapy, officially recognized in 1950, is a clinical intervention that addresses various psychological and cognitive deficiencies. Adolescents show a strong affinity for music, making it a potential treatment for depression, which is prevalent among this age group. This review explores studies focused on music therapy’s effects on brain function, individual psychotherapy, and group therapy for adolescents. Research suggests that music therapy positively influences brain activity by reducing cortisol levels and shifting brainwave patterns towards healthier states. In individual therapy, music …

Finding Meaning In Psychotherapy: A Literature Review Of Logotherapeutic Methodology In Psychotherapeutic Treatment, Jason M. Hoskin

Intuition: The BYU Undergraduate Journal of Psychology

Frankl’s logotherapy is a meaning-centered therapy, focusing on finding personal life purpose to improve one’s psychological well-being, particularly during personal struggle and suffering (Frankl, 1992). This literature review analyzes the empirical research measuring the efficacy of logotherapy in psychotherapy with a total of 27 articles from 2012–2022 reviewed and analyzed. Results illustrates that published contemporary empirical research on this topic focuses mainly on studying (1) theoretical principles of logotherapy through survey data, (2) the efficacy of logotherapy-based groups psychotherapy for individuals, or (3) psychometrics of frequently used instruments for measuring meaning in life. Overall, these categories corroborate the finding that …

Overcoming Social, Cultural, Physical And Covid-19 Barriers To Treatment For Eating Disorders Through Teletherapy, Wyatt W. Capener

Intuition: The BYU Undergraduate Journal of Psychology

Eating disorders (EDs) are among the deadliest of mental illnesses and may affect female, male, sexual and gender minorities, young, and old populations. The effects of EDs burden individuals with cultural, social, and physical inhibitors to seeking treatment and therefore may go untreated. Additionally, there is a nationwide lack of access to mental health professionals. EDs may link to a decrease in the quality of life and an increased mortality rate; therefore, it is imperative that individuals afflicted with EDs have access to treatment. The variety of symptoms associated with EDs calls for flexible solutions. The COVID-19 pandemic has affected …

How To Find Datasets, Ryan Hedrick

Day Family Research Lab Workshop Series

As open data and data sharing become more prominent within the realm of academic research, the need to know where to find this data continues to grow. In this workshop we will explore reputable data sources such as academic and government repositories. We will also examine how to find data within these sources and how to evaluate a found dataset’s quality.

The Efficacy Of Utilizing Artificial Intelligence Techniques In Developing Critical Thinking In Mathematics Among Secondary School Students And Their Attitudes Toward It, Mohammad A. Tashtoush, Aida B. Qasimi, Nawal H. Shirawia, Lubna A. Hussein

Iraqi Journal for Computer Science and Mathematics

The aim of this study is to investigate the efficacy of Artificial Intelligence (AI) techniques and programs in developing Critical Thinking Skills (CTSs) in mathematics among secondary school students, as well as their attitudes towards it. This study employed an experimental methodology, which was applied to a sample of 91 students. A critical thinking test and a scale to measure students' Attitudes Towards Mathematics (ATM) were also utilized. This study revealed significant improvements in the mean scores of critical thinking skills among secondary students who were exposed to Artificial Intelligence Techniques (AITs), particularly in deduction, interpretation, inference, and evaluation. Additionally, …

Commonwealth Times 2025-02-12

Commonwealth Times, 1969-

No abstract provided.

Perceptions And Role Of Cultural Competency In Clinical Social Work Practice, Vivian Adelaide Aba Dadzie

Walden Dissertations and Doctoral Studies

In practice, social workers are expected to translate cultural competency skills and knowledge they have acquired to handle diverse clients whose gender, racial, ethnic, religious, and personal beliefs and orientations can conflict. Using a qualitative research approach, the study addressed perceptions and roles of cultural competence in social work practice. Three research questions guided the study. The Campinha-Bacote framework of culturally competent healthcare was used for this study. The study involved employing thematic analysis to analyze research questions. It was determined that social workers must meet clients where they are culturally, respecting and learning from them to adapt interventions accordingly. …

Describing The Intersection Of Ethnicity And Gender In Early-Stage Non-Small Cell Lung Cancer, Hamza Rshaidat, Isheeta Madeka, Gregory L. Whitehorn, Jonathan Martin, Shale J. Mack, Sneha Alaparthi, Tyler R. Grenda, Nathaniel R. Evans Iii, Olugbenga T. Okusanya

Jefferson Hospital Staff Papers and Presentations

Objective

Methods

2025-02-12 Shen Ren Works With Cryopreservation In Hopes For A Better Future, Abdullah El-Sherbeeny

The Spectator Online

No abstract provided.

2025-02-12 Encouraging The Next Generation Of Art Curators, Kate Thompson

The Spectator Online

No abstract provided.

February 12, 2025 Blazer Weekly, University Of Alabama At Birmingham

Blazer Weekly (student newsletter)

No abstract provided.

The Lumberjack, February 12, 2025

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Novel Biomarkers Of Fetal And Neonatal Environmental Exposure, Effect And Susceptibility, Cynthia F. Bearer

Faculty Scholarship

Abstract: Rapid advancements in science and technology have allowed medical providers to treat wider ranges of diseases with safer and more effective therapies than ever before. One of the areas of health that has been consistently understudied, however, is one that affects us all: environmental health or the effects that the chemicals we are exposed to every day have on our acute and chronic health. This effect can be exacerbated during and shortly after pregnancy, as an individual exposure is often shared by both the mother and the fetus/neonate. The diagnosis and monitoring of chemical exposure can be quite challenging, …