Digital Commons Network^™

Identification Of Distinct Stool Metabolites In Women With Endometriosis For Non-Invasive Diagnosis And Potential For Microbiota-Based Therapies, Chandni Talwar, Goutham Venkata Naga Davuluri, Abu Hena Mostafa Kamal, Cristian Coarfa, Sang Jun Han, Surabi Veeraragavan, Krishna Parsawar, Nagireddy Putluri, Kristi Hoffman, Patricia Jimenez, Scott Biest, Ramakrishna Kommagani

Faculty, Staff and Students Publications

Background: Endometriosis, a poorly studied gynecological condition, is characterized by the presence of ectopic endometrial lesions resulting in pelvic pain, inflammation, and infertility. These associated symptoms contribute to a significant burden, often exacerbated by delayed diagnosis. Current diagnostic methods involve invasive procedures, and existing treatments provide no cure.

Methods: Microbiome-metabolome signatures in stool samples from individuals with and without endometriosis were determined using unbiased metabolomics and 16S bacteria sequencing. Functional studies for selected microbiota-derived metabolites were conducted in vitro using patient-derived cells and in vivo by employing murine and human xenograft pre-clinical disease models.

Findings: We discovered a unique bacteria-derived …

Multimodal Objective Assessment Of Impulsivity In Healthy And Mood Disorder Participants, Bishal Lamichhane, Nidal Moukaddam, Ramiro Salas, Wayne Goodman, Ashutosh Sabharwal

Faculty, Staff and Students Publications

Impulsivity represents an individual's tendency to act on urges without sufficient forethought. Heightened impulsivity is a hallmark of many mental health disorders. Objective impulsivity assessments could improve risk evaluation, diagnosis, and behavioral outcome monitoring in impulsivity-related health disorders. Towards objective impulsivity assessment, in this work, we identify impulsivity correlates in objective measurements, investigate their complementarity, and contrast impulsivity mechanisms across health conditions. We analyzed behavioral tests, heart rate variability (HRV), and fMRI-based brain connectivity in 227 healthy participants and 34 participants with mood disorders. Impulsivity dimensions had complementary correlates in objective measurements, with fMRI providing the strongest correlates. Multimodal assessment …

Pharmacokinetics Of Liposomal Levamisole After Oral, Intramuscular, And Subcutaneousadministration In Sheep, Hasan Susar, İzzet Karahan

Turkish Journal of Veterinary & Animal Sciences

This study aimed to determine the pharmacokinetics of free and liposomal levamisole in sheep following single oral (O),intramuscular (IM), and subcutaneous (SC) administrations at a dose of 7.5 mg/kg. The study developed a levamisole liposome andinvestigated relevant parameters: particle size, zeta potential, polydispersity index, encapsulation efficiency, pH, and morphology. TheBangham method, a thin-film hydration technique, was employed to prepare the liposomal levamisole. Blood samples were collectedby jugular venipuncture in heparinized tubes immediately before each free and liposomal levamisole treatment and at 2.5, 5, 10, 15,30, 60, 90, 120, 240, 360, and 480 min and 12, 16, and 24 h after …

Aberrant Homeodomain-Dna Cooperative Dimerization Underlies Distinct Developmental Defects In Two Dominant Crx Retinopathy Models, Yiqiao Zheng, Gary D Stormo, Shiming Chen

2020-Current year OA Pubs

Paired-class homeodomain (HD) transcription factors (TFs) play essential roles in vertebrate development, and their mutations are linked to human diseases. One unique feature of a paired-class HD is cooperative dimerization on specific palindrome DNA sequences. Yet, the functional significance of HD cooperative dimerization in animal development and its dysregulation in diseases remains elusive. Using the retinal TF cone-rod homeobox (CRX) as a model, we have studied how blindness-causing mutations in the paired HD, p.E80A and p.K88N, alter CRX's cooperative dimerization, leading to gene misexpression and photoreceptor developmental deficits in dominant manners. CRX

Teaching Sprinting As A Specialized Skill In Elementary Physical Education, Dillon R. Martinez, Scott Klepadlo

Essays in Education

This article highlights the gap between current physical grade-level outcomes and the practical implementation of sprinting instruction in elementary schools. This emphasizes the need for higher education institutions to learn from practicing elementary teachers, who have successfully incorporated sprinting into their elementary curricula. While pre-service physical education teachers are not typically taught how to teach sprinting as a specialized skill, some elementary PE teachers have developed effective methods for doing so. This article suggests that higher education practitioners should examine these practitioners to inform and improve their teacher preparation programs. This paper outlines several practical applications currently used in elementary …

Thermophilic Microbiota Of Fifth Water Hot Springs: A Genomic Perspective, Ethan Powers, Zack Galbraith, Trever Thurgood

Annual Research Symposium

Geothermal hot springs provide unique microbial habitats characterized by extreme temperatures, variable pH, and diverse geochemical conditions. This study investigates the microbial diversity of three hot spring locations in Diamond Fork Canyon, Utah—Diamond Fork Warm Springs, Fifth Water Hot Springs, and Monk’s Hollow Trailhead—using Oxford Nanopore MinION sequencing of the 16S rRNA gene. Samples were collected in triplicate and analyzed to identify the bacterial composition, with a focus on potential opportunistic pathogens. Our results revealed a diverse microbial community, including members of Pseudomonas, Comamonas, Helicobacter, and Flavobacterium, some of which are known for biofilm formation, antibiotic …

Noda News February 2025

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

A Comparative Analysis Of Antimicrobial Properties Of Silver Nanoparticles And Selenium Nanoparticles Coated Orthodontic Mini-Implants, Harshini S J, Saravanakumar S, Saravanadinesh S P, Prema Anbarasu, Balaji R

Annual Research Symposium

No abstract provided.

The Impact Of Electronic Cigarette Vapor And Cigarette Smoke On Oral Squamous Cell Carcinoma Invasion And Inflammation, Neha Patel

Annual Research Symposium

No abstract provided.

Dental Implants In Patients With Ectodermal Dysplasia: A Computer Guided Quad Zygomatic, Lorenzo Arcuri, Giacomo D'Angeli, Francesca Romana Federici Stanganelli, Alessio Zanza, Rodolfo Reda, Dario Di Nardo, Luca Testarelli, Massimo Galli

Annual Research Symposium

No abstract provided.

Evaluating The New Nd: Yag Laser Method In Phytosynthesizing Silver Nanoparticles And Assessing Their Medical Applications., Arshad Mahdi Hamad, Qanat Mahmood Atiya

Karbala International Journal of Modern Science

Silver nanoparticles (AgNPs) were synthesized via an innovative green synthesis method using amygdalin (Am) as a reducing agent and the Nd: YAG laser as a catalyst. We studied the properties of the nanoparticles using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM), ultraviolet-visible spectroscopy (UV), and Fourier transform infrared spectroscopy (FTIR) techniques. All the results of the examination demonstrate excellent structural and optical properties. In addition, the molecular docking of the complex composed of amygdalin and AgNPs was tested on three proteins concerned with the virulence of Pseudomonas aeruginosa and …

Influence Of Oil Density On Self-Propelled Motion Of Belousov-Zhabotinsky Reaction Droplet, Vivek Bharat Meshram, Anupama Sebastian, Puthiyapurayil Sibeesh, T K Shajahan

Northeast Journal of Complex Systems (NEJCS)

Belousov-Zhabotinsky reaction serves as an example of the nonlinear chemical oscillator in which the reacting substance undergoes sequential oxidation and reduction. A droplet containing the BZ reaction, when placed within the oily environment, can self-propel. In this experimental work, we explore the effect of oil medium density on the BZ reaction droplet dynamics. In an oil medium with lower density, the BZ droplet exhibits higher speed and effective diffusivity but a shorter lifetime. Both the distance and speed of the droplet initially increase with droplet volume. However, beyond a critical volume, the distance decreases while the speed stays constant. Interestingly, …

The Indiana Statesman, February 13, 2025, Indiana State University

Student Newspaper

Scan & Pay: parking payments made easierpayments easier; Department of Biology “3 billion missing birds”; Japanese Club hosts “Chocolate Day”

Montana Kaimin, February 13, 2025, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

How Hormonal Changes And The Oral Microbiome Interact With Periodontal And Alzheimer’S Disease To Influence Chronic Inflammation And Cognitive Decline?, Vanessa Chavez-Sinks, Kamran H. Awan

Annual Research Symposium

This review aims to investigate the potential of the bidirectional relationship between Alzheimer’s disease and periodontal disease. The Key players of hormonal fluctuations and microbiome dysbiosis emphasize the shared mechanisms that interplay among both conditions to identify the potential therapeutic opportunities.

Spectator 2025-02-13, Editors Of The Spectator

The Spectator

No abstract provided.

Drought Resilience And Legacy Effects In Two Forest Tree Species On Loess Plateau Of China: Growth And Water-Use Efficiency Under Different Drought Conditions, Lu Han, J. Julio Camarero, Guodong Jia, Zhiqiang Zhang, Lixin Chen

Aspen Bibliography

As droughts become more frequent and severer, understanding tree resilience and its role in mediating drought legacy effects (LEs) is critical for predicting forest ecosystem responses to future droughts and informing forest management. Both Pinus tabuliformis and Populus davidiana are widely distributed in the Loess Plateau region of western China and play important roles in provision of ecosystem services. In this study we quantified the LEs and resilience, including resistance (Rt) and recovery (Rc), of radial growth (BAI, basal area increment) and intrinsic water use efficiency (iWUE) of the two species, determined the external and internal factors influencing Rt and …

Towards More Sustainable Oceans: A Review Of The Pressing Challenges Posed By Marine Plastic Litter, Peter Yang

Faculty Scholarship

Marine littering is a global challenge and a significant threat to a sustainable planet, requiring comprehensive and effective mechanisms to address it in a comprehensive manner. This study reports on a bibliometric analysis that has identified the extent to which the topic has been explored in the international literature, by focusing on geographical scope, the emphasis on (micro)plastic litter and on policy measures. Additionally, as a complement to the assessment of the recent literature on marine plastic litter, this study reviews some case studies, identifying some trends on how to cope with this problem. The findings underscore the imperative for …

A Collective History On Arkansas Regional Organ Recovery Agency (Arora) And Their Adaptation To Donation Culture, Tara Jones

Theses and Dissertations

Arkansas Regional Organ Recovery Agency (ARORA) is continually addressing the organ shortage in Arkansas by increasing organ and tissue donation rates in Arkansas. Hospitals, Funeral Homes, and other referral partners collaborated with ARORA in their efforts to increase organ and tissue donation. Interviews from former and current ARORA employees, along with data analysis, highlight how ARORA worked to honor Arkansans decision to be a registered donor while also improving the procurement of organs. The findings reveal how ARORA adapted to donation culture related to public, cooperation with referral partners, among other barriers to create ARORA’s mission of “Restoring Lives” This …

Quaker Campus, February 13, 2025 (Vol. 23, Issue 9), Whittier College

Quaker Campus

No abstract provided.

Nurse Experiences Of Caring For Children With Autism Spectrum Disorder In Los Angeles Pediatric Intensive Care Units, Makenna Brown

Walden Dissertations and Doctoral Studies

One in 22 California children is diagnosed with autism spectrum disorder (ASD). In combination with sensory considerations, healthcare costs, and increased healthcare utilization, these children face a lesser quality of care and poorer health outcomes. The literature addresses healthcare needs and experiences from various viewpoints, but does not address the experiences of nurses (RN) caring for children with ASD in the pediatric intensive care unit (ICU). The purpose of this study was to gain an understanding of RN’s challenges, and the helpful strategies utilized in practice. A qualitative, grounded study approach, centered on the patient-and-family centered care conceptual framework, was …

Smart Textile Technology For The Monitoring Of Mental Health, Shonal Fernandes, Alberto Ramos Serrano, Mario Vega-Barbas, Carolina García-Vázquez, Fernando Seoane, Iván Pau

Artículos científicos

In recent years, smart devices have proven their effectiveness in monitoring mental health issues and have played a crucial role in providing therapy. The ability to embed sensors in fabrics opens new horizons for mental healthcare, addressing the growing demand for innovative solutions in monitoring and therapy. The objective of this review is to understand mental health, its impact on the human body, and the latest advancements in the field of smart textiles (sensors, electrodes, and smart garments) for monitoring physiological signals such as respiration rate (RR), electroencephalogram (EEG), electrodermal activity (EDA), electrocardiogram (ECG), and cortisol, all of which are …

Associations Between Atmospheric Ozone, Pm2.5 And Prevalence Of Diabetes In Georgia, United States, Kingsley A. Kalu, Jingjing Yin, Atin Adhikari

Journal of the Georgia Public Health Association

Objective:

This study examines the association between two air pollutants (PM_2.5 and ozone), and the prevalence of adult diabetes mellitus in relation to various confounding factors.

Methods:

We collected diabetes prevalence data from the 2015 County Health Ranking and Georgia Health Data Hub. A negative binomial regression analysis was conducted to examine the associations between the county-level dependent variable “adult diabetes” (for adults aged> 18 years diagnosed with Type 1 and Type 2 diabetes) and two independent county-level variables: percentage of days ³ NAAQS for ozone and PM_2.5 concentration levels while controlling for confounders.

Results:

At the county …

Pharmacogenomics Implications Of Tamoxifen In Breast Cancer Treatment: Clinical Relevance And Future Directions, Khalda E. M. Elhaj, Mahmoud M. E. Mudawi, Hamad A. Albagir A. Ali, Kamal A.A. Mohammed

Saudi Toxicology Journal

Tamoxifen is a cornerstone therapy for estrogen receptor-positive (ER+) breast cancer, improving survival and reducing recurrence. Its efficacy and toxicity, however, vary due to genetic polymorphisms influencing metabolism and transport. Key genes, such as CYP2D6, CYP3A4, and ATP-binding cassette transporters (ABCB1, ABCC2), are crucial in forming and distributing active metabolites like endoxifen. This review explores tamoxifen pharmacogenetics through an analysis of literature from PubMed, Scopus, Google Scholar, and PharmaGKB. Genetic variations like CYP2D6*10 in Asians and CYP2D6*17/29 in Africans impact therapeutic outcomes. Barriers to personalized tamoxifen therapy include inconsistent guidelines, limited access to genetic testing, and underrepresentation of ethnic groups …

February 2025 Graduate Council Minutes, University Of Nebraska At Kearney Graduate Council

Graduate Council Minutes

No abstract provided.

Affect Regulation And Mortality Risk: The Role Of Allostatic Load, Amanda E. Ng, Tara Gruenewald, Robert-Paul Juster, Claudia Trudel-Fitzgerald

Psychology Faculty Articles and Research

Objective:

Although growing evidence indicates that distinct affect regulation strategies (e.g., positive reappraisal, anger suppression) predict mortality risk, the biological processes involved remain understudied. We investigated the association of various affect regulation exposures with mortality risk while examining the role of allostatic load.

Method:

In 2004-2006, 1,941 participants from the Midlife in the United States longitudinal study completed validated scales assessing use of nine general and emotion-specific regulatory strategies (e.g., denial, anger expression). A standard deviation-based algorithm was also used to characterize how flexibly participants regulate their affect (lower, moderate, or greater variability). Participants further provided data on relevant covariates …

Hispanic Family Caregivers’ Experiences With Dementia Patients During The Covid-19 Emergency, Vivian Arroyo

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic significantly impacted caregiving dynamics, particularly for Hispanic family caregivers of dementia patients. This qualitative study explored the experiences, challenges, and coping strategies of these caregivers during the pandemic. The theoretical framework was systems theory. Semistructured interviews were conducted with 12 participants to collect data. Participants were recruited through purposive sampling and responded to open-ended questions regarding their caregiving experiences. The collected data were analyzed using Braun and Clarke’s six-step thematic analysis The findings revealed four themes: (a) caregiving strategies, including time management, collaboration, and reliance on religious faith; (b) self-care experiences, which highlighted the balance between personal …

Individual And Community-Level Factors Influencing Hiv Testing Among Malawian Women, Miniratu Coker Lawal

Walden Dissertations and Doctoral Studies

The HIV/AIDS epidemic poses a significant public health challenge in Malawi, where women aged 15-49 years experience a higher HIV prevalence (10.8%) compared to men (7.0%). Despite free testing services, 17% of Malawian women have never been tested for HIV, hindering early diagnosis and treatment that could reduce transmission rates. Using Anderson's framework for health service utilization, this study examined how demographic factors (age, marital status, ethnicity, residence) and socioeconomic factors (education, wealth, employment) influence HIV testing among Malawian women aged 15-49 years. Two research questions guided this investigation: 1) the association between demographic factors and HIV testing after controlling …

February 13, 2025, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Replacement Of Monensin With A Proprietary Tannin-Blend Additive In Calf-Fed Holstein Steer Diets, Sydney M. Bowman-Schnug, Luke K. Fuerniss, Joe D. Cameron, Jonathon L. Beckett, Muhammad Ahsin, Stephan Van Vliet, Guy D. Hufstedler, Bradley J. Johnson

Nutrition, Dietetics, and Food Sciences Faculty Publications

A proprietary tannin blend was evaluated as a potential ionophore replacement considering traits of feedlot cattle growth performance, carcass traits, and health. Holstein steers (n = 1450; initial shrunk body weight (SBW) = 141.6 ± 34.2 kg.) were blocked by origin and randomly assigned to receive a finishing diet containing one of two treatments: 1) 14,500 mg per head daily of Silvafeed ByProX (SBPX; ByPro/BX blend, Silvateam S.p.A, San Michele Mondovì, Italy) or 2) 180 mg per head daily of monensin (MON; Rumensin™ 90, Elanco, Greenfield, IN). Steers were on trial for 341 ± 11 days. Pen was the …