Digital Commons Network^™

Musculoskeletal Tumors Disguised As Orthopedic Injuries: A Case Report, A Summers

Clinical Practice in Athletic Training

Background: Musculoskeletal tumors are relatively rare, accounting for only 0.2 to 0.5% of all malignancies across all age groups. More specifically, Pigmented Villonodular Synovitis, a type of musculoskeletal tumor, has an incidence rate of 1.8 cases per one million people in a population. This benign, proliferative disease is a type of tenosynovial giant cell tumor that can affect the soft tissue lining of joints, bursae, and tendon sheaths. These joint-related tumors often present with an insidious onset and non-specific physical exam findings. Therefore, they are often mistaken for other, more common orthopedic injuries, making them difficult to diagnose. Patient Information: …

Enhancing Clinic Efficiency: A Quality Improvement Initiative For Postoperative Patient Care In An Outpatient Orthopedic Physician Practice Setting, D Stepan, T Jp Greffly, R M. Williams

Clinical Practice in Athletic Training

Introduction: Following orthopedic surgery, patient post-operative (post-op) visits are deemed global surgical observations where day 00 to day 90 are appointments that cannot be billed. Patients are typically seen 3 times during this global period. Thus, the outpatient clinic needs to have non-billable time slots each day for these patients. The current scheduling model double books patients every 15 minutes, with the physician being the primary provider seeing patients for post-op visits. Therefore, the clinic has demonstrated inefficiencies with scheduling these patients while having sufficient appointments available for billable patients. This quality improvement initiative aimed to decrease post-op patient visits …

Adolescent Femoral Neck Fractures: A Case Study On Initial Surgical Intervention, Avascular Necrosis Development, And Subsequent Total Hip Arthroplasty, K A. Fisher

Clinical Practice in Athletic Training

Background: The patient sustained a femoral neck fracture at the age of 13 after slipping and falling in his home. He was seen in the Emergency Department the same day and underwent a closed reduction and percutaneous pinning procedure the following morning. Ten weeks after returning to full weightbearing, and 13.5 weeks after his initial fracture, he developed stress fractures of the medial distal femoral and proximal tibial metaphyses. He experienced gradual worsening of hip pain and difficulty with ambulation between 11 to 13 months post-closed reduction and percutaneous pinning (CRPP). Avascular necrosis and collapse of the femoral head was …

Modification Of Ergonomics For A World-Class Brass Instrumentalist With A Congenital Limb Difference: Level 3 Case, O G. Newhouse

Clinical Practice in Athletic Training

Background: A drum and bugle corps is a musical marching organization that consists of approximately 160 brass, percussion, and color guard performers. There are currently twenty-one drum corps organizations at the world-class level that compete. Organizations learn their 8–10-minute show in the late spring and begin traveling the country performing and competing in the early summer until August. Rehearsal days can be up to 10 hours of practice including visual and music. It has been reported that the incidence of upper limb pain is higher in those who have longer practice times, in which is a symptom of overuse. These …

Title: Professional Socialization And Development Of Athletic Training Professional Program Directors, N A. Wilkins, K D. Pagnotta, L Kunkel, S David, A B. Thrasher

Clinical Practice in Athletic Training

Introduction: The role of Program Directors (PD) has vastly expanded over the last decade to meet the evolving demands of athletic training education and higher education. While specific responsibilities such as programmatic planning and accreditation maintenance are directly outlined in accreditation standards, PDs often assume additional institutional and programmatic responsibilities that now include recruitment and retention efforts, mentorship of faculty and students, curriculum design and mapping, and other administrative tasks. Previous research demonstrates athletic training faculty have little formalized training in administrative roles, and Coordinators of Clinical Education (CCEs) desired more support and development for that role. Little research exists …

Strength Assessment Protocol In Pre-Professional Ballet Dancers, Simona Di Nardo, Ivan Mascio

Clinical Practice in Athletic Training

Purpose: This research project aimed to investigate the effects, particularly regarding the ability to generate force, that could emerge following a ballet class. The purpose of the study was to support the thesis that low levels of fitness and performance in professional and amateur dancers, should be considered a significant gap that needs to be addressed. Larger will be the gap and bigger will be the demand of a dancer to be prepared athletically. While the shorter the gap and more efficient the artistic side of the dance performance will be. As a result, a stronger and healthier body will …

Characteristics Of Athletic Trainers That Are Satisfied And Dissatisfied With Their Compensation, K Ef Mair, J P. Young, L E. Eberman

Clinical Practice in Athletic Training

Introduction: Job satisfaction among athletic trainers (ATs), particularly in relation to compensation, is a critical factor influencing retention and career fulfillment. Examining the factors linked to earnings satisfaction may offer insight into how workplace conditions can be improved to better support ATs. The purpose of our study was to investigate the attributes that distinguish ATs content with their compensation from those who are dissatisfied. Methods: We used a cross-sectional, web-based survey to gather AT compensation data, of which 1,887 participants responded to a question regarding their satisfaction with compensation. Respondents were divided into two groups based on their satisfaction with …

Development Of A Conditional Plasmid For Gene Deletion In Non-Model Fusobacterium Nucleatum Strains, Peng Zhou, Bibek G C, Chenggang Wu

Faculty, Staff and Student Publications

Fusobacterium nucleatum is an opportunistic pathogen with four subspecies: nucleatum (FNN), vincentii (FNV), polymorphum (FNP), and animalis (FNA), each with distinct disease potentials. Research on fusobacterial pathogenesis has mainly focused on the model strain ATCC 23726 from FNN. However, this narrow focus may overlook significant behaviors of other FNN strains and those from other subspecies, given the genetic and phenotypic diversity within F. nucleatum. While ATCC 23726 is highly transformable, most other Fusobacterium strains exhibit low transformation efficiency, complicating traditional gene deletion methods that rely on non-replicating plasmids. To address this, we developed a conditional plasmid system in which …

Benefits Of Equilibrium Between Microbiota- And Host-Derived Ligands Of The Aryl Hydrocarbon Receptor After Stroke In Aged Male Mice, Pedram Peesh, Maria P Blasco-Conesa, Ahmad El Hamamy, Romeesa Khan, Gary U Guzman, Parisa Honarpisheh, Eric C Mohan, Grant W Goodman, Justin N Nguyen, Anik Banerjee, Bryce E West, Kyung Ae Ko, Janelle M Korf, Chunfeng Tan, Huihui Fan, Gabriela D Colpo, Hilda Ahnstedt, Lucy Couture, Solji Roh, Julia K Kofler, Jose F Moruno-Manchon, Michael E Maniskas, Jaroslaw Aronowski, Rodney M Ritzel, Juneyoung Lee, Jun Li, Robert M Bryan, Anjali Chauhan, Venugopal Reddy Venna, Louise D Mccullough, Bhanu Priya Ganesh

Faculty, Staff and Student Publications

Recent studies have highlighted the crucial role of microglia (MG) and their interactions with the gut microbiome in post-stroke neuroinflammation. The activation of immunoregulatory pathways, including the aryl hydrocarbon receptor (AHR) pathway, is influenced by a dynamic balance of ligands derived from both the host and microbiota. This study aimed to investigate the association between stroke-induced dysbiosis and the resultant imbalance in AHR ligand sources (loss of microbiota-derived [indole-based] and increase of host-derived [kynurenine-based]) after stroke. Microbiota-derived AHR ligands decreased in human plasma and remained low for days following an ischemic stroke highlighting the translational significance. Transient-middle-cerebral-artery-occlusion was performed in …

The Effects Of A Joint Reduction Trainer On Confidence Levels In Professional Athletic Training Students, T Franklin, S Hacherl

Clinical Practice in Athletic Training

Introduction: Dislocations are common injuries managed by athletic trainers, yet athletic training students are unlikely to practice reduction techniques during clinical experiences. Current standards set by the Commission on Accreditation of Athletic Training Education require accredited programs to prepare students to manage patients with dislocations, including joint reductions. Research indicates the use of simulation techniques, such as joint reduction simulators, in education can fill clinical experience gaps and improve student confidence and skills. Shoulder dislocations make up nearly 50% of dislocations with several reduction techniques identified in the current literature. The use of a joint reduction simulator may provide athletic …

Silencing Faf2 Mitigates Alcohol-Induced Hepatic Steatosis By Modulating Lipolysis And Pcsk9 Pathway, Nazmul Huda, Praveen Kusumanchi, Yanchao Jiang, Hui Gao, Themis Thoudam, Ge Zeng, Nicholas J. Skill, Zhaoli Sun, Suthat Liangpunsakul, Jing Ma, Zhihong Yang

School of Medicine Faculty Publications

BACKGROUND: Chronic alcohol consumption leads to lipid accumulation, oxidative stress, cellular damage, and inflammation in the liver, collectively referred to as alcohol-associated liver disease (ALD). FAF2/UBXD8/ETEA (Fas-associated factor 2) is a ubiquitin ligase adaptor protein that plays a crucial role in the ubiquitin-mediated degradation of misfolded proteins in the endoplasmic reticulum. A recent genome-wide association study indicated an association between FAF2 and ALD; however, the exact contribution of FAF2 to ALD pathogenesis remains unclear. METHODS: FAF2 was knocked down using AAV-delivered shRNA in C57/BL6 mice. Mice were subjected to a chronic-plus-single binge ethanol feeding (NIAAA) model. Nine hours after gavage, …

Chromosomal And Gonadal Sex Have Differing Effects On Social Motivation In Mice, Sneha M Chaturvedi, Simona Sarafinovska, Din Selmanovic, Katherine B Mccullough, Raylynn G Swift, Susan E Maloney, Joseph D Dougherty

2020-Current year OA Pubs

BACKGROUND: Sex differences in brain development are thought to lead to sex variation in social behavior. Sex differences are fundamentally driven by both gonadal hormones and sex chromosomes, yet little is known about the independent effects of each on social behavior. Further, mouse models of the genetic liability for the neurodevelopmental disorder MYT1L Syndrome have shown sex-specific deficits in social motivation. In this study, we aimed to determine if gonadal hormones or sex chromosomes primarily mediate the sex differences seen in mouse social behavior, both at baseline and in the context of Myt1l haploinsufficiency.

METHODS: Four-core genotypes (FCG) mice, which …

Assessing The Contribution Of Rare Protein-Coding Germline Variants To Prostate Cancer Risk And Severity In 37,184 Cases, Jonathan Mitchell, Niedzica Camacho, Patrick Shea, Konrad H Stopsack, Vijai Joseph, Oliver S Burren, Ryan S Dhindsa, Abhishek Nag, Jacob E Berchuck, Amanda O'Neill, Ali Abbasi, Anthony W Zoghbi, Jesus Alegre-Díaz, Pablo Kuri-Morales, Jaime Berumen, Roberto Tapia-Conyer, Jonathan Emberson, Jason M Torres, Rory Collins, Quanli Wang, David Goldstein, Athena Matakidou, Carolina Haefliger, Lauren Anderson-Dring, Ruth March, Vaidehi Jobanputra, Brian Dougherty, Keren Carss, Slavé Petrovski, Philip W Kantoff, Kenneth Offit, Lorelei A Mucci, Mark Pomerantz, Margarete A Fabre

Faculty, Staff and Students Publications

To assess the contribution of rare coding germline genetic variants to prostate cancer risk and severity, we perform here a meta-analysis of 37,184 prostate cancer cases and 331,329 male controls from five cohorts with germline whole exome or genome sequencing data, and one cohort with imputed array data. At the gene level, our case-control collapsing analysis confirms associations between rare damaging variants in four genes and increased prostate cancer risk: SAMHD1, BRCA2 and ATM at the study-wide significance level (P <  1×10−8), and CHEK2 at the suggestive threshold (P <  2.6×10−6). Our case-only analysis, reveals that rare damaging variants in AOX1 are associated with more aggressive disease (OR = 2.60 [1.75–3.83], …

Commensality In The Eateries Of Roman Pompeii, Amaya Yolanda Eckersley

Dissertations and Theses

Despite a nearly 300-year excavation history at Pompeii and many identified eating and drinking establishments, social behavior in these public or semi-public spaces has eluded significant research. Elite Roman literature is the traditional guideline for understanding Roman mealtimes and what they meant for social behavior. This literature, however, fails to accurately represent its sub-elite inhabitants. These sub-elites of Rome largely had their meals prepared outside of their homes. Pompeii is no exception and provides a massive boon for researchers willing to consider archaeological evidence. The buildings and evidence buried at Pompeii have ultimately shown a wide array of tabernae related …

Targeting Fatty Acid Synthase Reduces Aortic Atherosclerosis And Inflammation, Rodrigo Meade, Dina Ibrahim, Connor Engel, Larisa Belaygorod, Batool Arif, Fong-Fu Hsu, Sangeeta Adak, Ryan Catlett, Mingzhou Zhou, Ma Xenia G Ilagan, Clay F Semenkovich, Mohamed A Zayed

2020-Current year OA Pubs

Fatty acid synthase (FAS) is predominantly expressed in the liver and adipose tissue. It plays vital roles in de novo synthesis of saturated fatty acids and regulates insulin sensitivity. We previously demonstrated that serum circulating FAS (cFAS) is a clinical biomarker for advanced atherosclerosis, and that it is conjugated to low-density lipoproteins (LDL). However, it remains unknown whether cFAS can directly impact atheroprogression. To investigate this, we evaluate whether cFAS impacts macrophage foam cell formation - an important cellular process leading to atheroprogression. Macrophages exposed to human serum containing high levels of cFAS show increased foam cell formation as compared …

The Legal Framework Of Foster Care In Egypt: A Gender Analysis Of Alternative Families And Patrilineal Structures, Amira Fadel

Theses and Dissertations

The thesis explores women’s legal representation and agency over their non-biological children, and how the foster care system in Egypt either reinforces or deconstructs existing gender roles. Hence from a sociological perspective, it accounts for foster and alternative care laws in Egypt and the amendments thereof, to examine social relationships against the backdrop of more conventional, biological families, and kinship relations. In simple terms, studying foster and alternative care laws in Egypt is crucial to grasp how non-biological families are shaped in comparison to the more conventional bonds within biological families and traditional kinship relations, while accounting for the Christian …

Effective Protein-Protein Interaction Exploration With Ppi Retrieval

Defensive Publications Series

Effective Protein-Protein Interaction Exploration with PPI retrieval

Sovereign Lands, Brent D. Chicken, Tanner M. Boyzuick

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Oklahoma, Matt Schlensker, Sandra Fraley

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Colorado, David R. Little, Diana S. Prulhiere

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

The Effects Of Smokeless Tobacco Products And Affiliates On Epigenetic Changes And Biomarkers, Saad Saeed, Kamran Awan

Annual Research Symposium

No abstract provided.

Investigating The Relationship Between The Circadian Clock, Age, And Lifestyle, Samuel Park, Amaka Eziakonwa, Amega Nguyen, Madison Payne, Erich Stahmer, Alexis Salinas, Payson Broome, Angel Oliver, Christian Mccormick, Jasmyn Brown, Julie A. Zacharias-Simpson, Jutta Ward, Deborah Bell-Pedersen

Annual Research Symposium

This poster presentation aims to understand how circadian clock strength and phase are affected by age and lifestyle. By analyzing changes in physiological rhythms, the study seeks to develop strategies for promoting healthy aging by optimizing circadian function.

Evaluation Of A Global Capacity Development Project To Educate, Empower And Advance Sustainable Food Production, Felicia J. Tuggle, Olubusola W. Afolayan Msw, Mollie Smith M.Aq., David J. Cline Phd, Onesimus Kiadii Bs

Journal of Social Work in the Global Community

This article presents evaluation findings from the Integrated Aquaculture for Food Production, Education, Empowerment, and Development (iFEED) project, a global capacity development project designed to educate, empower, and advance sustainable food production in Monrovia, Liberia. To develop K–12 teachers’ capacity to integrate STEM education into math and science curriculum for the purpose of preparing a future aquaculture workforce in Liberia, the iFEED project provided educational materials, teacher training, and technical support to 25 teachers in the greater Monrovia Consolidated School District (MCSS). Evaluation findings indicate positive outcomes in increasing instructional capabilities among participating math and science teachers and accelerating action …

Queering ‘Common Sense’: Using Critical Discourse Analysis Of Lgbtq+ Book Bans In Florida Public Schools To Unmask Heteronormativity, Talia Zito, Nicole E. Morse

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Historically, censorship of LGBTQ+ content in education has been rooted in socio-political efforts to marginalize non-heteronormative identities. However, even those who oppose censorship tend to frame their arguments around concepts like “age-appropriateness” and “protecting children.” Our Critical Discourse Analysis examines formal challenges to And Tango Makes Three in one Florida school district in 2022 to show how these concepts are deployed on both sides of the debate. The book, depicting a same-sex penguin couple raising a chick, faced objections under Florida’s HB 1557, a law designed to restrict discussions of sexual orientation and gender identity in schools. Ultimately, the picture …

Nicotine-Driven Modulation Of Mtor Pathway In Oral Squamous Cell Carcinoma: A Cell-Specific Response To E-Cig Vapor Exposure, Kristina Vu

Annual Research Symposium

No abstract provided.

Muscle Metabolic Profile Following Acute Exercise In Mice With Constitutively Active Mtorc1, Hanna Kalenta, Sean P. Kilroe, Trevor B. Romsdahl, Erik D. Marchant, Rosario Maroto, Jennifer J. Linares, William K. Russell, Blake B. Rasmussen

International Journal of Exercise Science: Conference Proceedings

An increase in Mechanistic Target of Rapamycin Complex I (mTORC1) kinase activity stimulates muscle protein synthesis in response to amino acids, growth factors, energy, and mechanical stimuli. We previously found muscle hypertrophy and increased mitochondrial respiration in resting mice with chronically active mTORC1 (i.e., an inducible skeletal muscle specific DEPDC5 knockout (KO) model), but no improvement in muscle quality and function. PURPOSE: The purpose of this study was to determine the metabolic profile of skeletal muscle in DEPDC5 KO and wild-type (WT) male and female mice following 1-hour of treadmill exercise. METHODS: Targeted metabolomics was performed on quadricep …

Sustaining Critical Support Services For Relative Caregivers Through The Covid-19 Pandemic And Beyond, Shelly Willis Mrs, Lori Latimer, Rolanda Pyle

GrandFamilies: The Contemporary Journal of Research, Practice and Policy

This practice brief outlines model practice strategies for building and sustaining critical support services for kinship caregivers during the COVID-19 pandemic and beyond. While the long-term impacts of COVID-19 were still unfolding, research increasingly showed the profound effect the pandemic had on family well-being worldwide. Already managing the trauma that necessitated the placement of most children, kinship families faced additional challenges, including the fear and uncertainty surrounding health risks and the complete upheaval of community resources as schools, state offices, and social service agencies limited or closed their operations. This led to unprecedented levels of economic, housing, transportation, and food …

Socio-Demographic Factors Associated With Contraceptive Use Among Kuki Women In A Rural Setting: A Cross-Sectional Study, Lhingneilhai Kipgen, Henry Konjengbam, Jibonkumar Soibam

International Journal of Health and Allied Sciences

Background: Despite the global increase in contraceptive use, there is a dearth of research assessing contraceptive use among married Kuki women in Kangpokpi district, Manipur. The purpose of this work was to investigate the knowledge, use and non-use of contraceptives and the socio-demographic factors associated with them. Methods: This study employed a descriptive cross-sectional design. During the period of December 2018 to September 2019, interviews were conducted in ten villages of the Lhungtin and Saikul subdivisions of the Kangpokpi district in Manipur with married Kuki women who had at least one child. In total, 491 women were interviewed. The data …

Advances In Drug And Gene Delivery Strategies: Revolutionizing Breast Cancer Therapy, Sushma T, Madhusudhan M C, Umesha S

International Journal of Health and Allied Sciences

Breast cancer is a global health challenge, demanding innovative therapeutic approaches to improve patient outcomes. Nanotechnology has emerged as a promising avenue, facilitating targeted drug delivery to breast cancer cells while minimizing off-target effects. Nanoparticle-based formulations, including liposomes, polymeric nanoparticles and lipid-based nanoparticles offer precise control over drug release kinetics and enhanced bioavailability. Furthermore, gene delivery platforms have garnered attention for their potential to modulate gene expression and overcome drug resistance mechanisms in breast cancer. Moreover, the integration of innovative technologies, like CRISPR-Cas9 gene editing and RNAi, holds promise for targeted gene manipulation and personalized treatment approaches in cancer therapy.

“Phytochemical Analysis, In Vitro Anti-Oxidant, Anti-Diabetic And Anti-Inflammatory Activity Of Red Kidney Bean (Phaseolus Vulgaris L.) ”, Nancy Mani, D Annette Beatrice, R Durga Priyadarshini

International Journal of Health and Allied Sciences

Aims: The aim of the study is to assess the phytochemicals, bioactive compounds and determine the in vitro anti-oxidant, anti-diabetic and anti-inflammatory potential of red kidney bean.

Methods and Material: Raw and cooked red kidney bean (Phaseolus vulgaris. L) were assessed for phytochemical content, anti-oxidant, anti-diabetic and anti-inflammatory activity and GC-MS analysis was done to identify the bioactive compounds.

Statistical analysis used: Descriptive statistics, independent ‘t’ test and one-way ANOVA was computed to determine the differences in the phytochemical compounds and in vitro activities of raw and cooked red kidney beans.

Results: Qualitative analysis of raw and …