Digital Commons Network^™

Program Review Report 4-1-25, Angela Brock

Program Review Committee

No abstract provided.

Plasmidlens: Leveraging Genomic Language Models To Detect Plasmids From Bacterial Sequences, Ajinkya Patil, Mahdi Baghbanzadeh, Brendan Mann, Ali Rahnavard, Keith A. Crandall

GW Research Showcase 2021-2026

No abstract provided.

Drawing Lines In The Sand: Armed Conflict, Climate Damage And Setbacks To Climate Action, Beatrice L. Hamilton

Michigan Journal of Environmental & Administrative Law

Armed conflicts have a significant and detrimental effect on the climate system, with considerable implications for efforts to mitigate and adapt to climate change and the civilian population. Yet the environmental provisions under the law of armed conflict (LOAC), drafted some half a century ago, struggle to adequately address these concerns. This article assesses the capacity of LOAC to address conflict-driven climate damage and its cascading impacts by characterizing these harms as environmental damage and as injury to civilians. The analysis highlights opportunities for broadening LOA C's scope and offers recommendations to enhance its capacity to address climate damage and …

Making Super Soldiers: Command Authority And The Implications Of “Getting To Yes”, Christopher J. Lin

Health Matrix: The Journal of Law-Medicine

The capability and will to enhance soldiers’ minds and bodies for warfare have existed throughout the centuries and across nations, from Ancient Greek hoplites partaking in wine before battle to calm nerves, to American servicemembers consuming amphetamines to remain awake during long-range reconnaissance missions in the Vietnam War. With advancements in biomedical technology, certain types of enhancements entail modifications with varying degrees of permanence to enhance battlefield performance. This Article explores the historical context and contemporary developments of biomedical enhancements, with a focus on the longstanding deference to military command authority regarding issues of individual autonomy. By examining the impacts …

Investigation Of Melt Rheology For Direct Powder Extrusion (Dpe) 3d Printing, Asmaa Alawbali, Lynn Ogot

2025 Graduate Student Research Symposium

Additive Manufacturing (also known as 3D printing) is a versatile technology that can aid in developing personalized medicine while maintaining cost and time efficiency. Currently, fused deposition modeling (FDM) is one of the most common 3D printing techniques used in the production of pharmaceutical drugs. However, FDM faces a few limitations, such as a two-step printing process and exposing material to multiple thermal processing steps, making it disadvantageous for clinical applications. Direct Powder Extrusion (DPE) is a recently developed 3D printing technology that is gaining popularity in the pharmaceutical research industry for its single-step printing process, making it ideal for …

Investigation Of The Hdl Molecular Architecture Before And After Exercise Training., Prasun Kumar Dev

Theses and Dissertations

The functional characteristics of high-density lipoprotein (HDL) particles are influenced by their structure, including their molecular composition (e.g. HDL lipidome and proteome). However, the effects of exercise training on HDL molecular composition and its relationship with HDL-related traits are largely unknown. In this ancillary study, we investigated the HDL lipidome and proteome of 154 adults before and after 20 weeks of exercise training in the HERITAGE Family Study. The HDL-sized plasma fraction was isolated utilizing FPLC-SEC, followed by untargeted lipidomic and proteomic analysis using LC/MS. We identified 341 known lipid species while 409 HDL associated proteins. Clinical and functional related …

Barriers In Receiving A Diagnosis Of Sanfilippo Syndrome: Perceptions From Healthcare Providers And Caregivers, Cassidy Lena

Theses and Dissertations

Sanfilippo syndrome (MPS III) is a rare, degenerative condition characterized by symptoms impacting neurological functioning, behavior, and quality of life. Diagnosis is often not made until three to six years of age, but comprehensive and effective symptom management have been reported to optimize patient longevity. The aim of this study was to identify barriers to diagnosis and the corresponding impact on patients. This study surveyed healthcare providers and caregivers of individuals with Sanfilippo syndrome. Both quantitative and qualitative methods were employed to assess provider knowledge and comfortability in managing Sanfilippo syndrome. Additionally, it explored caregiver perspectives on healthcare system navigation, …

A Metagenomic Investigation Of Temporal Changes In Wastewater Microbiome Across North Carolina A&T State University Campus, Shilpi Bhatia, Dongyang Deng Ph.D.

2025 Graduate Student Research Symposium

Wastewater microbial communities are highly dynamic, exhibiting significant variation over time. We employed Next-Generation Sequencing to identify various SARS-CoV-2 variants of concern, followed by a shotgun metagenomic approach to examine the relative abundance of pathogens in wastewater associated with SARS-CoV-2 across the North Carolina A&T State University campus. Biweekly grab samples were collected across the NCA&T State University campus between January 2021 and December 2023. RT-qPCR results revealed higher concentrations of SARS-CoV-2 RNA in wastewater samples from 2021-2022 compared to 2023. Targeted sequencing detected all major variants of concern, including Alpha, Delta, and Omicron, in 2021-2022 samples. Additionally, a shotgun …

Ipulse: April 2025, Lynn University

Student Newspapers

Issues:

• April 2025 - Volume 8
• April 2025 - Volume 9 - Mega Edition

Investigation Of The Effects Of The Peptidylarginine Deiminase Inhibitor Cl-Amidine On Apoptosis And Gene Expression In Ovarian Cancer, Victoria Walden

Longwood Senior Thesis Proposal

Peptidylarginine deiminases (PADs) are a family of enzymatic proteins responsible for the conversion of arginine and methylarginine residues to citrulline. This conversion is important for several key cellular processes including transcriptional gene regulation. Recently, a link has been established between overexpression of a particular PAD, PAD4, and the accelerated progression of both autoimmune diseases and cancers. Ovarian cancer exhibits heightened levels of PAD4 in affected cells. High levels of PAD4 are associated with the formation of neutrophil extracellular traps (NETs) that promote cancer metastasis, and downregulation of the p53 apoptotic pathway. Thus, it is important to explore inhibitors of PAD4. …

Authenticity Under Review: How Well Does Genai Write College Admissions Essays?, Adrian Mangine

IPHS 300: AI for Humanity

With nearly 30% of people ages 14-22 reporting frequent AI use, increasing AI assistance in college admissions essays poses a new consideration with ethical AI use (Rubin et al., 2024). This study investigates how well three generative AI models write college admissions essays: ChatGPT o3, Gemini 2.5 Pro, and Grok. Each model responded to a Common App 2025-2026 application prompt as three distinct applicants: Elijah, Grace, and Malik (Common App, 2025). Each student represented a common college applicant archetype: Elijah, an academically successful dual sports recruit; Grace, a near-perfect award-winning scholar; and Malik, a gifted student from an underrepresented background. …

Click-Based Synthesis Of Hemibastadin Derivatives And Their Applications As Antimicrobial And Biofilm Inhibiting Agents, James B. Daniel Iii

Longwood Senior Thesis Proposal

Antimicrobial agents are one of the most important tools used in the medical industry. With the ever growing numbers of antibiotic resistant bacteria, new strategies have been developed to combat them, one of which being biofilm inhibiting agents. A class of molecules called hemibastadins, first discovered from sea sponges, have been of recent interest in the field. Building from previous work done in this lab on hemibastadins, a hemibastadin derivative containing a triazole in place of the oxime has been identified as a potential antibiofilm agent. This work will target a derivative that will more closely mimic the hemibastadins found …

Associations Between B Vitamin Interactions With Polyunsaturated Fatty Acids And Cognitive Function Among Cognitively Healthy Older People As Modified By Amyloid Status And Sex, Chuliang Zhao, Karen A. Abbott, Chinedu Momoh, Geraint Price, Oliver J. K. Robinson, Sujin Kang, Celeste A. De Jager Loots

Brain and Mind Institute

Background/Objectives: Nutrients such as vitamin B12, folate (B9), and polyunsaturated fatty acids (PUFAs) may independently influence cognitive health, but their combined effects and interactions remain unclear. This study aims to investigate the effects of B12, folate, and PUFAs, including their interactions, on cognitive function in cognitively healthy older adults, considering effect modification by sex and amyloid-beta status.

Methods: A cross-sectional analysis was conducted using data from 321 participants aged 60–85 y enrolled in the UK CHARIOT–PRO SubStudy. Dietary intake was assessed using the Scottish Collaborative Group Food Frequency Questionnaire, and cognitive performance was measured via the Repeatable Battery …

Electronic Resources Updates - 2025 Q1, Brigitte Galauner, Gregg Harris

Electronic Resources Quarterly Updates

No abstract provided.

Ceremonia De Graduación - 2025, Governors State University

Commencement Documents and Videos

17 de mayo de 2025
10:00 h

Estudiante ponente: Sra. Catherine Miles

Facultad de Educación y Desarrollo Humano
Facultad de Salud y Servicios Humanos

17 de mayo de 2025
16:00 h

Estudiante ponente: Sra. Kaylie Dahms

Facultad de Administración de Empresas
Facultad de Artes y Ciencias

Commencement Program: 2025, Governors State University

Commencement Documents and Videos

May 17, 2025
10 a.m.

Student Speaker: Ms. Catherine Miles

College of Education and Human Development
College of Health and Human Services

May 17, 2025

4 p.m.

Student Speaker: Ms. Kaylie Dahms

College of Business
College of Arts and Sciences

College Of Natural Sciences Newsletter, Spring 2025, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Page 1 Dean's Message from Dr. Sen Subramanian
Page 2 Student Spotlights
Page 3 Kaushik honored, Three-Minute Thesis, & Ice Cores revealed
Page 4 Alumni Spotlight
Page 5 Day of Scholars
Page 6 Cyanide research, Record Research Expenditures, Adhikari awarded Miller Research Award
Page 8 Hanson Receives NSF Grant
Page 9 Snow Lab Research Team
Page 10 Faculty Awards
Page 11 Drone Day
Page 13 Khalaf Awarded Presidential Award

Mapping Trends In Gender-Inclusive Legal Language Between Circuit Courts In The United States, Juliette M. Rhinow

Student Publications

This study examines the use of gender-inclusive legal language in federal circuit court opinions in the United States between 2020 and 2024, with a focus on how judicial political ideology influences linguistic behaviors. Drawing on postmodern feminist theory and utilizing content analysis, the research compares six federal circuit courts by coding 46 court opinions for inclusive and exclusive linguistic practices related to transgender and non-binary individuals. Inclusive practices included the use of self-identified names and pronouns, affirming decisions, and acknowledgment of transgender identities, while exclusive practices involved misgendering, outdated terminology, and restrictive rulings. Results show that progressive circuits demonstrated significantly …

The Relationship Between Precision Strikes And Terrorist Activity, Connor A. Joyce

Student Publications

Precision warfare is intended to reduce the human costs for allied combatants in conflict. However, as this new form of fighting becomes increasingly central to modern military campaigns, its impact on terrorist activity warrants close examination. This paper explores the psychological effects of trauma on terrorist behavior, engages with scholarly debates on the outcomes of precision tactics, and presents statistical analysis to argue that the United States’ use of precision warfare, from 2000 through 2019, contributed to increased amounts of terrorist activity. Empirical findings in Somalia, Yemen, and Afghanistan support this claim. Precision tactics have been known to save American …

Tracking Phenological Shifts Of Black Guillemots Cepphus Grylle In The Gulf Of Maine, Jocelyn L. Little

Student Publications

Rapid warming in the Gulf of Maine has coincided with changes in phenology across trophic levels. Phenological change has yet to be studied in black guillemots (Cepphus grylle), a widely distributed benthic forager that is showing population decline in the region. Because black guillemots nest in burrows, their phenology can be challenging to study. I developed methods to track black guillemot phenology on Petit Manan Island, a seabird breeding colony in the Gulf of Maine. Specifically, I asked Q1) Can daily tower count data be used to predict black guillemot breeding phenology? Q2) How is black guillemot breeding phenology shifting …

Common Terns (Sterna Hirundo) As Bioindicators For Atlantic Herring (Clupea Harengus) Distribution In The Gulf Of Maine, Logan R. Becker

Student Publications

Effective fisheries management is increasingly challenged by climate-driven shifts in species distribution and by a lack of data on early life stages of key forage fish species. In the Gulf of Maine, Atlantic herring (Clupea harengus), a once economically dominant fishery species and a key prey species for many dependent predators, has declined due to poor early-stage recruitment and warming waters. Despite this decline, current trawl surveys do not inform early-stage Atlantic herring distribution due to mesh size limitations, leaving critical gaps in our knowledge. To address this knowledge gap, I used common terns (Sterna hirundo) …

A Multiple Case Study Of Four-Year Public, Non-Flagship Universities: Meeting Common Institutional Goals Of Increased Enrollment And Academic Profile, Alicia Kornowa

Dissertations

For several reasons, the number of students seeking and enrolling in a postsecondary education has started to decline in the United States (U.S.) and the decrease is expected to intensify for the foreseeable future. This trend is cause for concern among higher education enrollment leaders, especially those who serve at institutions not among the most elite universities or without a national brand—the campuses researchers project will have the greatest difficulty maintaining enrollment levels. Using strategic enrollment management (SEM) as an example of general systems theory and systems thinking, this multiple case study explored how four public, four-year, non-flagship institutions increased …

Assessing The Feasibility Of Transportable Nuclear Reactors: A Radiological Risk Case Study, Robert John Demuth

Theses and Dissertations

The feasibility of a truly transportable nuclear reactor presents significant radiological challenges that must be addressed to ensure compliance with regulatory limits and operational safety. This study evaluates the radiological constraints associated with the transportability of the Transportable Helium-cooled One-megawatt Reactor (THOR), focusing on neutron activation, shielding performance, and external radiation exposure. Using advanced radiation transport and activation modeling within the SCALE framework, a comprehensive analysis was conducted to quantify dose rates during operation, post-shutdown, and transport. A key aspect of this work involved assessing activation products in core materials, auxiliary components, and surrounding environments to determine their contribution to …

Activation Of Basal Forebrain Afferents Following Systemic Inflammation, Alexis Morgan Blas

Theses and Dissertations

Sepsis is a large-scale immune response typically due to an imbalance of pro- and anti-inflammatory responses due to some type of infection or insult. Around 1.7 million adults in the United States will develop it each year, making it the leading cause of increased morbidity and mortality in hospitals. Sepsis can lead to many different symptoms, one of which is delirium. Delirium is a mental state of confusion and disorientation and involves delusions, hallucinations, memory issues, and most commonly inattention. Delirium is more prevalent in older individuals which leads to further complications and a higher likelihood of development of long-term …

Small-Molecule Mitotic Inhibitors As Anticancer Agents: Discovery, Classification, Mechanisms Of Action, And Clinical Trials, Yazmin Salinas, Subhash Chauhan, Debasish Bandyopadhyay

School of Medicine Publications

Despite decades of research, cancer continues to be a disease of great concern to millions of people around the world. It has been responsible for a total of 609,820 deaths in the U.S. alone in 2023. Over the years, many drugs have been developed to remove or reduce the disease’s impact, all with varying mechanisms of action and side effects. One class of these drugs is small-molecule mitotic inhibitors. These drugs inhibit cancer cell mitosis or self-replication, impeding cell proliferation and eventually leading to cell death. In this paper, small-molecule mitotic inhibitors are discussed and classified through their discovery, underlying …

Baseline Associations Of Office And Ambulatory Blood Pressure Monitoring With Cognitive Function And Dementia Prevalence, Jesus Melgarejo, Dhrumil Patil, Sokratis Charisis, Kristina P. Vatcheva, Silvia Mejia-Arango, Luis J. Mena, Claudia Satizabal, Eron G. Manusov, Sudha Seshadri, Gladys E. Maestre

School of Medicine Publications

Background: High blood pressure has been associated with dementia prevalence and incident. However, it is unclear the relationship of office and ambulatory BP monitoring with cognitive function and dementia and in particular, it remains unknown whether ambulatory BP variability relates to dementia.

Objective: To investigate the associations of office and 24-h blood pressure (BP) with cognitive function and dementia prevalence.MethodsCross-sectional population-based study of 1435 participants aged ≥40 years with office BP/24-h BP, and cognitive assessments (Mini-Mental State Examination [MMSE] and Selective Reminding Test [SRT]). Dementia was diagnosed with a clinical dementia rating ≥1.0. Statistics included logistic and linear regression models. …

Relevance Of Cellular Homeostasis-Related Gene Expression Signatures In Distinct Molecular Subtypes Of Breast Cancer, Sharda P. Singh, Chathurika S. Dhanasekara, Michael W. Melkus, Chhanda Bose, Sonia Y. Khan, Flavia Sardela De Miranda, Maria F. Mahecha, Prrishti J. Gukhool, Sahil S. Tonk, Se-Ran Jun

School of Medicine Publications

Background: Breast cancer is a complex and heterogeneous disease characterized by distinct molecular subtypes with varying prognoses and treatment responses. Multiple factors influence breast cancer outcomes including tumor biology, patient characteristics, and treatment modalities. Demographic factors such as age, race/ethnicity, menopausal status, and body mass index have been correlated with variations in incidence, mortality, and survival rates. Over the past decade, comprehensive genomic profiling has been widely used to identify molecular biomarkers and signatures to develop novel therapeutic strategies for patients. For instance, the FLEX registry (NCT03053193) enrolled stage I-III breast cancer patients across 90 institutions in the …

Unraveling Early Onset Disparities And Determinants: An Analysis Of Colorectal Cancer Outcomes And Trends In Texas, Tyler Torres, Elias Arellano Villanueva, Yossef Alsabawi, Demba Fofana, Manish Tripathi

School of Medicine Publications

Introduction: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the U.S., with disparities in incidence, survival, and age at diagnosis across racial, ethnic, and socioeconomic groups. The rising incidence of early-onset CRC (< 50 years) has amplified concerns regarding access to care, screening disparities, and outcomes, particularly among minorities. This study examines the impact of race, ethnicity, socioeconomic status (SES), and sex on CRC survival and age at diagnosis in Texas from 1995 to 2016.

Methods: This retrospective cohort study utilized Texas Cancer Registry (TCR) data, including 235,076 CRC cases diagnosed between 1995 and 2016. Kaplan-Meier analysis and log-rank tests assessed 10-year survival by race and ethnicity and time period (1995-2005 vs. 2006-2016). Kruskal-Wallis tests with Bonferroni correction were used to compare survival years between racial/ethnic groups within each period. Age at diagnosis was analyzed by race and …

Electronic Hearing Protection: Advancements And Applications, Amanda Mattei

Doctoral Scholarly Projects & Capstones

Noise-induced hearing loss (NIHL) represents a significant and irreversible public health concern and is classified as the most prevalent occupational illness in the United States (Masterson et al., 2013). Prolonged exposure to hazardous noise levels precipitates auditory impairment and correlates with other comorbid health risks, including tinnitus (Tufts & Berger, 2022). While traditional hearing protection devices (HPDs) have been implemented extensively to mitigate NIHL, persistent issues such as user discomfort, barriers to effective communication, and compromised situational awareness impede their optimal utilization (Melamed et al., 1994; Neitzel & Seixas, 2005).

Recent innovations in electronic HPDs have emerged, targeting these limitations …

Climate Change Fairy Tales (Complete Collection And Epub), St. Mary's University

Climate Change

This is the complete collection of fairy tales in one download