Digital Commons Network^™

Policy And Practice: Analyzing Abortion Laws And Their Relationship To Competent Women’S Health Services In Ohio, Daija Smith

MUSC Theses and Dissertations

This study examines the relationship between abortion policy changes and women’s health services, focusing specifically on the state of Ohio’s evolving abortion laws and their implications. Using a qualitative approach, the research explores competency's role in addressing mental health disparities among diverse populations and marginalized communities. Through analyzing state policies and interviews with healthcare advance practice providers, this study completed a thematic analysis that identified opportunities such as shaping access and quality of care. The findings aim to inform strategies that reduce health disparities and improve competent care in women’s health services.

The Impact Of Diet-Induced Obesity On Cerebrovasculature Structure And Function, Riley M. Feagle

MUSC Theses and Dissertations

Adequate cerebral perfusion is necessary to help the brain maintain a constant and steady state of nutrient delivery. Since the brain is highly metabolic, changes in the vasculature structure can impact perfusion levels and, therefore, reduce the ability of the brain to receive the support necessary for full functionality. Vascular dysfunction is a common comorbidity among obese individuals. Given the strong association between obesity and cognitive dysfunction, understanding the correlation between reduced cerebral perfusion and altered cerebrovascular structure is crucial. The overall hypothesis of this thesis originated after ample preliminary data, and states that diet-induced obesity reduces cerebral perfusion and …

Boron Nitride Nanosheets, Quantum Dots, And Dots: Synthesis, Properties, And Biomedical Applications, Raksha Dubey, Matthew Cowles, Zohreh Salimi, Xiuling Liu, Rodney Oakley, Nazmiye B. Yapici, Join Uddin, Dongyan Zhang, Yoke Khin Yap

Michigan Tech Publications

This review examines three aspects of hexagonal boron nitride (h-BN) nanomaterials: properties, synthesis methods, and biomedical applications. We focus the scope of review on three types of h-BN nanostructures: boron nitride nanosheets (BNNSs, few-layered h-BN, larger than ∼100 nm in lateral dimensions), boron nitride quantum dots (BN QDs, smaller than ∼10 nm in all dimensions, with inherent excitation-dependent fluorescence), and boron nitride dots (BN dots, smaller than ∼10 nm in all dimensions, wide bandgap without noise fluorescence). The synthesis methods of BNNSs, BN QDs, and BN dots are summarized in top-down and bottom-up approaches. Future synthesis research should focus on …

East End Elegy: Leyla Mccalla, Artist-In-Residence, Department Of Music, University Of Richmond

Music Department Concert Programs

No abstract provided.

The Effects Of Birth Order And Sibling Dynamics On The Future, Loa Thorkelson

Psychology Student Publications

This paper explores the nature versus nurture debate and its relevance to sibling dynamics. This is followed by an exploration of the relationships between birth order and sibling dynamics on future education and possible obesity development.

April 2025 Graduate Council Minutes, University Of Nebraska At Kearney Graduate Council

Graduate Council Minutes

No abstract provided.

Phosphotungstic Acid Staining To Visualize The Vagus Nerve Perineurium Using Micro-Ct, Aniruddha R. Upadhye, Jennifer Coleman, Michael W. Jenkins, David Wilson, Andrew J. Shoffstall

Faculty Scholarship

Background and Purpose: Peripheral nerve stimulation is approved by the US Food and Drug Administration for treating various disorders, but it is often limited by side effects, highlighting the need for a clear understanding of fascicular and fiber organization to design selective therapies. Micro-CT imaging of contrast-stained nerves enables the visualization of tissue microstructures, such as the fascicular perineurium and vasculature. In this work, we evaluated phosphotungstic acid (PTA) as a contrast agent and assessed its compatibility with downstream histology. Methods: Human vagus nerve samples were collected from three embalmed cadavers and subjected to three different staining methods, followed by …

A Computational Framework For Investigating Novel Bacterial Conjugation Inhibitors, Serena Tuytschaevers

Theses

Antimicrobial resistance (AMR) is a major global threat, contributing to an estimated 700,000 deaths annually. One of the main ways that AMR genes spread among bacteria is through conjugation. Therefore, it is crucial to develop conjugation inhibitors (COINs) to combat AMR. Shared characteristics between known COIN molecules are a hydrophobic tail, unsaturations, and a polar head. Considering these characteristics and accounting for the efficacy of 2-hexadecynoic acid and Tanzawaic Acids (TZAs) low toxicity, we designed a new set of TZA analogs. The predicted protein target of previously identified COINs is TrwD, an ATPase in the type IV secretion system (T4SS). …

The Cowl - V. 88 N. 19 - April 10, 2025

The Cowl

The Cowl - student newspaper of Providence College. Vol. 88 No. 19 - April 10, 2025. 16 pages.

The Interchangeable-Part Structure Of Food And Drug Law, Adam I. Muchmore

Faculty Scholarship

This Article demonstrates that nested tiers of interchangeable parts serve as the foundation for the regulatory programs administered by the U.S. Food and Drug Administration. Core interchangeable parts used in FDA-administered programs include product categories, prohibitions on adulteration and misbranding, agency-registration requirements, current good manufacturing practices, product standards, marketing authorization requirements, postmarket requirements, and user fees. In each of these areas, Congress or the FDA has engaged in interchangeable-part lawmaking (IPL). IPL occurs when a government takes a portion of its law in one subject area and uses it as a model for its own law in another subject area. …

Limiting Step Therapy On Mental Health Medications: Why A More Expansive Approach Is Needed, Joseph Keller

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

We’Re All In This Together: A Proposal For Stronger Response To Invasive Plant Species, Marisa Nardelli

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Montana Kaimin, April 10, 2025, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Allosteric Targeted Drug Delivery For Enhanced Blood-Brain Barrier Penetration Via Mimicking Transmembrane Domain Interactions, Kaicheng Tang, Zhongjie Tang, Miaomiao Niu, Zuyin Kuang, Weiwei Xue, Xinyu Wang, Xinlong Liu, Yang Yu, Seongdong Jeong, Yifan Ma, Annette Wu, Betty Y S Kim, Wen Jiang, Zhaogang Yang, Chong Li

Faculty, Staff and Student Publications

Current strategies for active targeting in the brain are entirely based on the effective interaction of the ligand with the orthosteric sites of specific receptors on the blood-brain barrier (BBB), which is highly susceptible to various pathophysiological factors and limits the efficacy of drug delivery. Here, we propose an allosteric targeted drug delivery strategy that targets classical BBB transmembrane receptors by designing peptide ligands that specifically bind to their transmembrane domains. This strategy prevents competitive interference from endogenous ligands and antibodies by using the insulin receptor and integrin α

April 10, 2025, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Isolation And Characterization Of Cellulase Enzyme From Sago Bettle Larvae, Amalyah Febryanti, Maswati Baharuddin, Tendri Abeng

Chimica et Natura Acta

Sago beetle larvae are larvae that consume cellulose and convert it into simple compounds with the help of cellulase enzymes. The enzyme is produced by bacteria found in the larvae's intestines. This study aims to characterize the cellulase enzyme from R8W bacteria, which is a cellulolytic bacterium and derived from sago beetle larvae. The characterization in this research included determination of the optimum temperature, the optimum pH, and the optimum substrate concentration of the enzyme. The methods in this study consisted of the production of enzymes; characterization of cellulase enzyme by DNS method; and measurement of cellulase enzyme activity on …

Dukunolide D From The Root Of Lansium Domesticum Corr. Cv Kokosan, Angela Suryana, Andi Hairil Alimuddin, Rudiyansyah Rudiyansyah

Chimica et Natura Acta

Lansium domesticum has three varieties and one of the varieties is kokosan. These plants contain limonoids as the main constituents. Phytochemical investigation of L. domesticum cv kokosan has identified onoceranoids-type triterpenoids and tetranortriterpenoids from the seeds, fruit peels, and bark except for the root. This research described dukunolide D (1) that has been obtained from the methanol extract of the root of kokosan. Methanol root extract was fractioned by n-hexane and dichloromethane (DCM). All fractions including the crude extract were screened for phytochemical test. The DCM fraction was chromatographed in order to obtain compound 1. DART-HRMS of compound 1 showed …

Her2-Selective Tyrosine Kinase Inhibitor, Zongertinib (Bi 1810631), In Patients With Advanced/Metastatic Solid Tumors With Her2 Alterations: A Phase Ia Dose-Escalation Study, John V Heymach, Frans Opdam, Minal Barve, Hai-Yan Tu, Yi-Long Wu, David Berz, Lukas Schröter, Yanick Botilde, Behbood Sadrolhefazi, Josep Serra, Kiyotaka Yoh, Noboru Yamamoto

Faculty, Staff and Student Publications

Purpose: Human epidermal growth factor receptor 2 (HER2) alterations occur in many solid cancers, including non-small cell lung cancer (NSCLC). Beamion LUNG-1 (ClinicalTrials.gov identifier: NCT04886804) is assessing the safety/efficacy of zongertinib (BI 1810631), a novel HER2-selective tyrosine kinase inhibitor that spares epidermal growth factor receptor, in patients with HER2-altered solid tumors.

Materials and methods: Beamion LUNG-1 is an ongoing multicenter, multicohort phase Ia/Ib trial. Phase Ia assessed zongertinib administered twice a day (15-150 mg) or once daily (60-360 mg) in pretreated patients with various tumors, including NSCLC. Primary end points were maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs); …

The Zbtb24-Cdca7-Hells Axis Suppresses The Totipotent 2c-Like Reprogramming By Maintaining Dux Methylation And Repression, Dan Guo, Zeling Du, Youqi Liu, Meiqi Lin, Yue Lu, Swanand Hardikar, Yanna Xue, Jinghong Zhang, Taiping Chen, Jiameng Dan

Faculty, Staff and Student Publications

Two-cell-like cells (2CLCs), a rare population (∼0.5%) in mouse embryonic stem cell (mESC) cultures, are in a transient totipotent-like state resembling that of 2C-stage embryos, and their discovery and characterization have greatly facilitated the study of early developmental events, such as zygotic genome activation. However, the molecular determinants governing 2C-like reprogramming remain to be elucidated. Here, we show that ZBTB24, CDCA7, and HELLS, components of a molecular pathway that is involved in the pathogenesis of immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome, function as negative regulators of 2C-like reprogramming by maintaining DNA methylation of the Dux cluster, a master …

Kenyon Collegian - April 10, 2025

The Kenyon Collegian

No abstract provided.

Hierarchical Lineage Tracing To Unravel Mechanisms Of Cancer Treatment Resistance, Rachel Danielle Saxe

Dartmouth College Ph.D Dissertations

Cancer cells adapt to treatment, leading to the emergence of clones that are more aggressive and resistant to anti-cancer therapies. We have a limited understanding of the development of treatment resistance as we lack technologies to map the evolution of cancer under the selective pressure of treatment. To address this, we developed a hierarchical, dynamic lineage tracing method called FLARE (Following Lineage Adaptation and Resistance Evolution). We use this technique to track the progression of acute myeloid leukemia (AML) cell lines through exposure to Cytarabine (AraC), a front-line treatment in AML, in vitro and in vivo. We map distinct cellular …

Brewers’ Yeast (Saccharomyces Cerevisiae) Purified Functional Feed Additives Mitigate Soybean Meal-Induced Enteritis In Atlantic Salmon (Salmo Salar) Parr, Taofik A. Momoh, Sheu Gbolahan Odu-Onikosi, Folasade Damilola Amulejoye, Joshua Wilson, Benjamin Eynon, Holger Kühlwein, Victor Kuri, Daniel L. Merrifield

School of Biological and Marine Sciences

Soybean meal (SBM) is commonly used in aquafeeds due to its wide availability, reasonable protein content, and cost-effectiveness. However, high SBM inclusion levels in the diets of carnivorous fish, such as Atlantic salmon (Salmo salar), can cause soybean meal-induced enteritis (SBMIE), resulting in compromised gut health, reduced nutrient absorption, and impaired growth. An 8-week study was conducted to evaluate the potential of brewers’ yeast-derived functional feed additives (FFAs), specifically yeast cell wall β-glucans (PβG [purified β-glucan]) and yeast cytosolic extracts (YEs), to mitigate the adverse effects of SBMIE in Atlantic salmon parr. Fish were fed diets containing 30% SBM (30-SBM) …

Crop Advisor Approaches To Soil Health Advising And Opportunities For Improvement, Peggy Petrzelka, Jessica D. Ulrich-Schad, Matt Yost, Jenae Dean, Earl Creech, Linda Schott, Tony Richards, Kristy Davis

All Current Publications

In this report, we use data from a 2023 online survey of crop advisors in Utah and Idaho to examine how they are working with their clients on soil health and where opportunities for improvement exist.

Cognitive Correlates Of Borderline Personality Disorder Features In Youth With Bipolar Spectrum Disorders And Bipolar Offspring, Alessio Simonetti, Sherin Kurian, Evelina Bernardi, Antonio Restaino, Francesca Bardi, Claudia Calderoni, Gabriele Sani, Jair C Soares, Kirti Saxena

Faculty, Staff and Student Publications

Background: Bipolar disorder (BD) and borderline personality disorder (BPD) share common cognitive impairments. These deficits are also shared by bipolar offspring (BD-OFF). Nevertheless, little is known regarding the association between cognitive impairments and BPD features in youth with BD and BD-OFF. Objectives: This study aimed to investigate the association between BPD features and cognitive impairments in youth with BD and BD-OFF.

Methods: Thirty-nine participants (7-17 years) with BD, 18 BD-OFF, and 50 healthy controls (HCs) were recruited. BPD features were assessed using the Borderline Personality Features Scale for Children (BPFS-C). Deficits in executive functions and affective processing were assessed using …

Ethical Concerns And Implications Of Expanded Carrier Screening, Emily Andres

Student Research Symposium

The rapid evolution in the field of genetics is often met with uncertainty and skepticism. With the advancements in genetic technologies, expanded carrier screening (ECS) has emerged as a powerful tool in reproductive medicine. While ECS provides prospective parents with insight into their genetic risk, it also raises serious ethical questions for many.

Impacts Of Reef Fish Length On Foraging Radius: Exploring Behavioral Patterns Within A Patch Reef Ecosystem, Kilia Brawand

Student Research Symposium

Introduction

Coral reefs support high levels of marine biodiversity

• Patch reefs serve as vital refuges for small fish.
• Predation risk shapes how far fish stray from their reef, creating a “foraging radius”— the maximum distance traveled before retreating.

Absolute swimming speed in fish increases with body size (1).

• Therefore, larger fish may travel farther away from their refuge to forage over greater areas

This study tested the following question: Does a reef fish’s length influence how far it travels from its patch reef refuge?

Investigation Of Immune/Performance Trade-Offs In Neonate Children's Pythons, Ellie Hartman

Student Research Symposium

Introduction

Energetic trade-offs are a key consideration when understanding an organism’s life history. One of these tradeoffs occurs between investment in immunity and performance.

• Individuals that invest more energy into immunity may be less equipped to avoid predation or find food, while those prioritizing performance may be more susceptible to infection
• Hypothesis: In response to a novel antigen, neonate snakes will have an immune response we can measure by counting immune cells. Additionally, we predict that strike frequency, swim speed, and endurance will be reduced in snakes undergoing an immune response and that with greater immune response we will see …

Evaluating The Effects Of Oxidative Stress On Primary Retinal Pigment Epithelial Cells, Sophia Hessami

Student Research Symposium

Introduction

Age-Related Macular Degeneration (AMD) is the leading cause of vision loss worldwide, affecting 200 million adults over the age of 40

• Affects subretinal layers: retinal pigment epithelium (RPE), Bruch’s membrane, and choroid (Fig. 1)

Problem: Early mechanisms of AMD are not well understood; oxidative stress is often cited as a key contributing factor to the development of AMD.3 Current studies neglect to use primary RPE cells when investigating oxidative stress.

Oxidative Stress occurs when there is an imbalance between reactive oxygen species (ROS) production and cellular antioxidant defenses

• Overabundance of ROS results in damage to tissue and …

Evaluating The Stress System Of The Grieving Brain: Corticotropin-Releasing Factors And Partner Loss In Coyotes, Rachel Tong

Student Research Symposium

Introduction

Social bonds are fundamental and essential

• Positive and negative effects

The stress system¹ :

• Corticotropin-releasing factor (CRF) system
• CRFR1 and CRFR2
• Acts on the HPA axis, amygdala, and hippocampus

Genetic monogamy is common among coyotes

Importance:

• Coyotes’ greatest threat are humans
• An abandoned partner can disrupt biology and behavior

Animals experience social loss too!

Phylogeny And Historical Biogeography Of Uroleucon Aphids, Audrey Mullen

Student Research Symposium

Research Questions

• Are South American Uroleucon aphids endemic or recently introduced?

• If endemic, did the aphids come from North America or Eurasia?

• When did dispersal events occur?

• Did temperate zone-adapted Uroleucon aphids cross through equatorial tropical forest?